Kyle J. Norton
Green tea may have a therapeutic and positive effect in improved glucose metabolism, some scientists suggested.
Green tea is a precious drink processed numbers of health benefit, known to almost everyone in Asia and the Western world.
Glucose metabolism is an action of the body to convert glucose intake to energy for the needs of body tissue and organs through oxidized glucose to carbon dioxide and water.
Stages of abnormal glucose metabolism stretch from mild forms of glucose intolerance (pre-diabetes) to diabetes and finally to pregravid forms of diabetes associated with the end-organ disease.
Long-term abnormal glucose metabolism is considered a leading cause of diabetes and diabetic complications.
Some researchers even suggested that abnormalities of glucose metabolism can induce excess body weight and increase potentially modifiable risk factors for cardiac morbidity and mortality.
And, long-term of impaired glucose tolerance (IGT) is considered as a marker for the state of insulin resistance and prediction of vessel vascular complications, independent of a patient’s progression to diabetes.
Normal blood glucose level (tested while fasting) of healthy individuals are in the range of 3.9 and 5.5 mmol/L (70 to 100 mg/dL). ...and no more than 7.8 mmol/L (140 mg/dL) 2 hours after eating.
Green tea extract, in the evaluation of the carbohydrate metabolic key enzymes in control and streptozotocin high fat diet-induced diabetic rats in 30 days, demonstrated significant activity in ameliorated overexpression of plasma glucose, glycosylated hemoglobin (HbA1c) and increase in the levels of insulin and hemoglobin.
Expression of hemoglobin A1c is the average level of blood sugar over the past 2 to 3 months.
The normal hemoglobin molecule measured in a volume of blood is 13.8 to 17.2 grams per deciliter (g/dL) for men and 12.1 to 15.1 g/dL for women.
Further analysis also found that the application exerted a profound effect to restore, to some extent, the function of altered activities of the key enzymes of carbohydrate metabolism, such as hexokinase, pyruvate kinase, lactate dehydrogenase in both diabetic and control groups.
Abnormal (over 10−5M or 0.9 mg%) function of hexokinase in converted glucose into glucose-6-phosphate was associated moderate to severe hypoglycemia.
Pyruvate Kinase is an enzyme with function in catalyzed last step of glycolysis.
Deficiency of pyruvate kinase is associated with the risk of metabolic disorders.
Lactate dehydrogenase (LDH or LD) is an enzyme with a function to catalyze the conversion of lactate to pyruvic acid and back.
In diabetic rats group, green tea extract strongly averted the abnormal expression of glycogen phosphorylase in the liver to near normal levels.
Additionally, diabetic group after administration of green tea extract exhibited antihyperglycemic potential, observed through improved muscle and hepatic glycogen content.
Glycogen phosphorylase is an enzyme with the function to release sugar from cells.
The findings showed that green tea extract has a direct implication in attenuating abnormal glucose metabolism in comparison to the effectiveness of conventional medicine metformin, a standard oral hypoglycemic drug.
Moreover, in the study to confirm the epidemiological studies' suggestion of green tea in improvement of glucose metabolism in diabetic mice, researchers found that injection of green tea in diabetic mice and streptozotocin-induced diabetic mice after 2-6 h expresses lower levels of glucose with no alternation of serum insulin level, at dose of 300 mg/kg in compared to normal and control mice.
In protein differentiation, green tea extract administration decreased the serum protein level with function in stimulated glucose production and minimized the increase in blood glucose levels by stimulating additional small amounts of insulin in diabetes.
These results addressed another impact of green tea function in exerted direct influence in the modulation of glucose metabolism in the tested subjects.
Interestingly, in the investigation of green tea's effect on glucose uptake inhibitory activity in Caco-2 cells, scientists also indicated that green tea at a temperature of 60 degrees Celsius significantly improves the capacity of antioxidants in the inhibition of glucose uptake through regulation of cell glucose metabolism.
Incredibly, in temperatures over 60 degrees Celsius, green tea application did not increase or showed an upward trend in the inhibitory potential, the Huazhong Agricultural University suggested.
Taken together, green tea with abundant bioactive phytochemicals may be considered as a functional food in improved glucose metabolism in reduced risk of diabetes onset.
People with high-risk diabetes such as prediabetics may want to add 1 or 2 cups of green tea into their daily diet for preventive measures.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Modulatory effect of green tea extract on hepatic key enzymes of glucose metabolism in streptozotocin and high fat diet-induced diabetic rats by Sundaram R1, Naresh R, Shanthi P, Sachdanandam P.(PubMed)
(2) Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans by Tsuneki H1, Ishizuka M, Terasawa M, Wu JB, Sasaoka T, Kimura I.(PubMed)
(3) Effect of steeping temperature on antioxidant and inhibitory activities of green tea extracts against α-amylase, α-glucosidase and intestinal glucose uptake by Liu S1, Ai Z2, Qu F3, Chen Y4, Ni D5. (PubMed)
Monday, 10 July 2023
Vitex agnus-castus (VAC) HydroalcoholicExtract Processes Hypoglycemic and Pancreatic Protective Effects Aganst Type 1 and 2 #Diabetes, Researchers Find
Kyle J. Norton
Chaste tree berries may have the potential in stimulated pancreatic islet regeneration in reducing the risk of development and treatment of Type I and II diabetes, some researchers suggested.
Diabetes is a condition characterized by insufficient insulin entering the bloodstream in the regulation of levels of glucose.
The disease is either caused by cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.
In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belongings to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.
According to the study, diabetes rats induced by streptozotocin treated with extract of chaste tree berry displayed a significant effect in increased volume density of pancreatic islet as well as the percentage of β-cells and size of the islet.
Decreased volume and weight of pancreatic islets are associated with juvenile-onset, insulin-dependent diabetes.
Percentage of β-cells is greatly reduced already at the clinical onset of type II diabetes.
However, the reduction of the number of β-cells are more moderate than in insulin-dependent juvenile-onset diabetic subjects and in some case, it does not account for the disease.
And, altered islet composition and disproportionate loss of size of islet are associated linearly with patients with type II diabetes.
Pancreatic islets are the regions of the pancreas containing hormone-producing cells,
Dr. Oche O, the lead researcher said, "Plant extracts, (exhibited) regeneration of β-cells along with β-cells repairs, in compared to non-treated diabetic control which showed complete degeneration of the islet cells".
Furthermore, the study also found that the levels of total bilirubin, direct bilirubin, and unconjugated bilirubin are significantly lower in the treated group in comparison to the control.
Compared to healthy control, the median bilirubin level was significantly higher in diabetes.
More important, in D-galactose induces pancreatic disorder along in aging mouse model, treatment of Vitex agnus-castus (VAC) demonstrated potential pancreatic protective and hypoglycemic effects through improved the size of pancreatic islets that were decreased in aged and D-galactose groups.
Galactose D is a type of monosaccharide sugar, considered as sweet as glucose.
In a total of 72 adult female Naval Medical Research Institute (NMRI) mice (weighing 30-35 g) were divided into 6 groups: control, VAC hydroalcoholic extract, D-galactose, D-galactose + VAC hydroalcoholic extract, aged, aged + VAC hydroalcoholic extract through subcutaneous injection of D-galactose for 45 days and then VAC hydroalcoholic extract gavaged twice a day in the last 7 days. 24 h after the last drug and extract administrations, the group treated with Chaste tree berry extract or combinations of the extract showed increased insulin and decreased serum glucose and D-galactose level compared to other treatment groups.
The study also found, "Despite the size of pancreatic islets decreased in aged and D-galactose groups, ........... VAC hydroalcoholic extract has hypoglycemic and pancreatic protective effects in naturally aged and aging model mice".
In fact, there is a report indicated that oral administration of iridoid glucoside isolated from chaste tree berry once daily to diabetic rats for a period of 30 days is effective as glibenclamide, a known hypoglycemic drug, at a concentration of 50 mg/kg body weight.
Promisingly, iridoid glucoside reversed hyperglycemia-induced biochemical changes to near-normal levels.
Collectively, Chaste tree berries may be used as a functional food for the treatment of Type I and Type II diabetes through the hypoglycemic and pancreatic protective effects.
However, further data collection on studies performed with human consumption during the course of the disease will be necessary to complete the picture of its antidiabetes possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299
Sources
(1) Pancreatic islet regeneration and some liver biochemical parameters of leaf extracts of Vitex doniana in normal and streptozotocin-induced diabetic albino rats by Oche O1, Sani I1, Chilaka NG1, Samuel NU1, Samuel A1. (PubMed)
(2) Pancreatic protective and hypoglycemic effects of Vitex agnus-castus L. fruit hydroalcoholic extract in D-galactose-induced aging mouse model by Ahangarpour A1, Oroojan AA2, Khorsandi L3, Najimi SA4.(PubMed)
(3) Antihyperglycemic effect of iridoid glucoside, isolated from the leaves of Vitex negundo in streptozotocin-induced diabetic rats with special reference to glycoprotein components by Sundaram R1, Naresh R, Shanthi P, Sachdanandam P.(PubMed)
(4) The pancreatic islets in diabetes by Gepts W, Lecompte PM(PubMed)
Chaste tree berries may have the potential in stimulated pancreatic islet regeneration in reducing the risk of development and treatment of Type I and II diabetes, some researchers suggested.
Diabetes is a condition characterized by insufficient insulin entering the bloodstream in the regulation of levels of glucose.
The disease is either caused by cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.
In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belongings to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.
According to the study, diabetes rats induced by streptozotocin treated with extract of chaste tree berry displayed a significant effect in increased volume density of pancreatic islet as well as the percentage of β-cells and size of the islet.
Decreased volume and weight of pancreatic islets are associated with juvenile-onset, insulin-dependent diabetes.
Percentage of β-cells is greatly reduced already at the clinical onset of type II diabetes.
However, the reduction of the number of β-cells are more moderate than in insulin-dependent juvenile-onset diabetic subjects and in some case, it does not account for the disease.
And, altered islet composition and disproportionate loss of size of islet are associated linearly with patients with type II diabetes.
Pancreatic islets are the regions of the pancreas containing hormone-producing cells,
Dr. Oche O, the lead researcher said, "Plant extracts, (exhibited) regeneration of β-cells along with β-cells repairs, in compared to non-treated diabetic control which showed complete degeneration of the islet cells".
Furthermore, the study also found that the levels of total bilirubin, direct bilirubin, and unconjugated bilirubin are significantly lower in the treated group in comparison to the control.
Compared to healthy control, the median bilirubin level was significantly higher in diabetes.
More important, in D-galactose induces pancreatic disorder along in aging mouse model, treatment of Vitex agnus-castus (VAC) demonstrated potential pancreatic protective and hypoglycemic effects through improved the size of pancreatic islets that were decreased in aged and D-galactose groups.
Galactose D is a type of monosaccharide sugar, considered as sweet as glucose.
In a total of 72 adult female Naval Medical Research Institute (NMRI) mice (weighing 30-35 g) were divided into 6 groups: control, VAC hydroalcoholic extract, D-galactose, D-galactose + VAC hydroalcoholic extract, aged, aged + VAC hydroalcoholic extract through subcutaneous injection of D-galactose for 45 days and then VAC hydroalcoholic extract gavaged twice a day in the last 7 days. 24 h after the last drug and extract administrations, the group treated with Chaste tree berry extract or combinations of the extract showed increased insulin and decreased serum glucose and D-galactose level compared to other treatment groups.
The study also found, "Despite the size of pancreatic islets decreased in aged and D-galactose groups, ........... VAC hydroalcoholic extract has hypoglycemic and pancreatic protective effects in naturally aged and aging model mice".
In fact, there is a report indicated that oral administration of iridoid glucoside isolated from chaste tree berry once daily to diabetic rats for a period of 30 days is effective as glibenclamide, a known hypoglycemic drug, at a concentration of 50 mg/kg body weight.
Promisingly, iridoid glucoside reversed hyperglycemia-induced biochemical changes to near-normal levels.
Collectively, Chaste tree berries may be used as a functional food for the treatment of Type I and Type II diabetes through the hypoglycemic and pancreatic protective effects.
However, further data collection on studies performed with human consumption during the course of the disease will be necessary to complete the picture of its antidiabetes possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299
Sources
(1) Pancreatic islet regeneration and some liver biochemical parameters of leaf extracts of Vitex doniana in normal and streptozotocin-induced diabetic albino rats by Oche O1, Sani I1, Chilaka NG1, Samuel NU1, Samuel A1. (PubMed)
(2) Pancreatic protective and hypoglycemic effects of Vitex agnus-castus L. fruit hydroalcoholic extract in D-galactose-induced aging mouse model by Ahangarpour A1, Oroojan AA2, Khorsandi L3, Najimi SA4.(PubMed)
(3) Antihyperglycemic effect of iridoid glucoside, isolated from the leaves of Vitex negundo in streptozotocin-induced diabetic rats with special reference to glycoprotein components by Sundaram R1, Naresh R, Shanthi P, Sachdanandam P.(PubMed)
(4) The pancreatic islets in diabetes by Gepts W, Lecompte PM(PubMed)
#GreenRoastedCoffee Reduces #VisceralFat Content, BodyWeight and #Hepatic TG Levels in #Obesity, According to Studies
Kyle J. Norton
Coffee, a popular and social beverage, is a drink made from roasted beans from the Coffea plant, native to tropical Africa and Madagascar.
Green roasted coffee intake may have a profound effect in reduced risk and treatment of obesity, some studies suggested.
Compared to regular roasted coffee, green coffee roasted beans contain substantial higher levels of chlorogenic acid.
The phytochemical is considered a weight loss plant-based supplement due to its effect in significantly lowering body weight, visceral fat mass, and plasma leptin and insulin levels, according to the Sunchon National University.
A BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity.
According to the statistic, 68% of the American population are either overweight or obese.
How to calculate your BMI index
BMI= weight (kg)/ height (m2)
According to the joint study of the health benefits of coffee studies over last 10 years, led by the Huanggang Normal University, injection of green bean coffee daily and regularly expressed a significant improvement of risk and treatment of obesity through its function in decreased lipid accumulation in cells during fat metabolism.
In form of animal and humans studies, green coffee consumption induced changes in transcription factors in fat deposit, decreased body weight and visceral fat
Furthermore, coffee influenced gut microbiota in obese animals and humans studies also expressed the importance of green coffee as a functional and integrated food in reduced risk and treatment of obesity as microbiota in the gastrointestinal tract are found to be altered in obese individuals.
Some researchers suggested that these alternations are associated with long-term unhealthy diets in the induction of abnormal function of microbiota in regulated energy harvest from food components and energy storage in the host.
Dr. Kyle J. Wolf, the lead authors in the study of Gut Microbiota and Obesity said, “…… by the fact that adult germ-free (GF) (ie, bacteria-free) C57BL/6 mice had a 60% increase in body fat content when they were conventionalized (ie, colonized) with cecal microbiota from a healthy, normal C57BL/6 mouse”.
Other in the study of obesity-induced in mice using an HFD for four weeks, fed only HFD or HFD with GCBE at 50, 100, and 200 mg/kg suggested that
* Mice treated with green coffee showed a significantly decreased body weight gain, liver weight and white adipose tissue weights and regulated adipose tissue lipolysis hormones, such as adiponectin and leptin.
*. Mice treated with green coffee intake also demonstrated a decreased mRNA expression levels of adipogenesis and adipocyte metabolism related genes in adipose tissues and the liver, and decreased the corresponding protein expression.
*. GCBE-treated mice had a lower fat mass with decreased relative body weight and fat mass in compared to HFD-alone-fed mice.
Increased liver weight was associated with toxic liver and liver dysfunction.
White adipose tissue weights increased are associated with metabolic changes that occur in white adipose tissue (WAT) with obesity.
Obese patients are found to associate with increased adipose tissue lipolysis hormones.
Obesity is associated with adverse alterations in adipose tissue that predispose to adipocyte metabolic dysregulation.
Adipogenesis is the process of cell differentiation of pre-adipocytes to adipocytes. These processes of adipose hypertrophy and hyperplasia are associated with intracellular abnormalities of adipocyte function that leads to clinical manifestations and sequelae of obesity.
According to the information collected, Dr. Choi BK, the lead author said, “GCBE has a potential anti-obesity effect with lowering body fat accumulation by regulating adipogenesis and lipid metabolism-related genes and proteins in WAT and liver”.
More importantly, in the study of male ddy mice fed a standard diet containing GCBE and its principal constituents, namely, caffeine and chlorogenic acid, for 14 days, researchers at the Oryza Oil & Fat Chemical Co,, Ltd, indicated that
* . GCBE with 0.5% and 1% reduced visceral fat content and body weight
*. Caffeine and chlorogenic acid showed a tendency to reduce visceral fat and body weight
*. Oral administration of GCBE (100 and 200 mg/kg. day) for 13 days showed a tendency to reduce hepatic TG in mice
*. Chlorogenic acid (60 mg/kg. day) reduced hepatic TG level
The findings displayed a strong effect of coffee and its phytochemicals in promoting weight loss and reduced accumulation by inhibition of fat absorption and activation of fat metabolism in the liver.
Green coffee intake daily and regularly may be considered as a functional and integrated food against risk and treatment of obesity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Molecular mechanisms of the anti-obesity effect of bioactive compounds in tea and coffee by Pan MH1, Tung YC2, Yang G3, Li S3, Ho CT4.(PubMed)
(2) Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice by Choi BK1, Park SB2, Lee DR1, Lee HJ2, Jin YY3, Yang SH4, Suh JW5. (PubMed)
(3) Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice by Shimoda H1, Seki E, Aitani M.(PubMed)
Coffee, a popular and social beverage, is a drink made from roasted beans from the Coffea plant, native to tropical Africa and Madagascar.
Green roasted coffee intake may have a profound effect in reduced risk and treatment of obesity, some studies suggested.
Compared to regular roasted coffee, green coffee roasted beans contain substantial higher levels of chlorogenic acid.
The phytochemical is considered a weight loss plant-based supplement due to its effect in significantly lowering body weight, visceral fat mass, and plasma leptin and insulin levels, according to the Sunchon National University.
A BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity.
According to the statistic, 68% of the American population are either overweight or obese.
How to calculate your BMI index
BMI= weight (kg)/ height (m2)
According to the joint study of the health benefits of coffee studies over last 10 years, led by the Huanggang Normal University, injection of green bean coffee daily and regularly expressed a significant improvement of risk and treatment of obesity through its function in decreased lipid accumulation in cells during fat metabolism.
In form of animal and humans studies, green coffee consumption induced changes in transcription factors in fat deposit, decreased body weight and visceral fat
Furthermore, coffee influenced gut microbiota in obese animals and humans studies also expressed the importance of green coffee as a functional and integrated food in reduced risk and treatment of obesity as microbiota in the gastrointestinal tract are found to be altered in obese individuals.
Some researchers suggested that these alternations are associated with long-term unhealthy diets in the induction of abnormal function of microbiota in regulated energy harvest from food components and energy storage in the host.
Dr. Kyle J. Wolf, the lead authors in the study of Gut Microbiota and Obesity said, “…… by the fact that adult germ-free (GF) (ie, bacteria-free) C57BL/6 mice had a 60% increase in body fat content when they were conventionalized (ie, colonized) with cecal microbiota from a healthy, normal C57BL/6 mouse”.
Other in the study of obesity-induced in mice using an HFD for four weeks, fed only HFD or HFD with GCBE at 50, 100, and 200 mg/kg suggested that
* Mice treated with green coffee showed a significantly decreased body weight gain, liver weight and white adipose tissue weights and regulated adipose tissue lipolysis hormones, such as adiponectin and leptin.
*. Mice treated with green coffee intake also demonstrated a decreased mRNA expression levels of adipogenesis and adipocyte metabolism related genes in adipose tissues and the liver, and decreased the corresponding protein expression.
*. GCBE-treated mice had a lower fat mass with decreased relative body weight and fat mass in compared to HFD-alone-fed mice.
Increased liver weight was associated with toxic liver and liver dysfunction.
White adipose tissue weights increased are associated with metabolic changes that occur in white adipose tissue (WAT) with obesity.
Obese patients are found to associate with increased adipose tissue lipolysis hormones.
Obesity is associated with adverse alterations in adipose tissue that predispose to adipocyte metabolic dysregulation.
Adipogenesis is the process of cell differentiation of pre-adipocytes to adipocytes. These processes of adipose hypertrophy and hyperplasia are associated with intracellular abnormalities of adipocyte function that leads to clinical manifestations and sequelae of obesity.
According to the information collected, Dr. Choi BK, the lead author said, “GCBE has a potential anti-obesity effect with lowering body fat accumulation by regulating adipogenesis and lipid metabolism-related genes and proteins in WAT and liver”.
More importantly, in the study of male ddy mice fed a standard diet containing GCBE and its principal constituents, namely, caffeine and chlorogenic acid, for 14 days, researchers at the Oryza Oil & Fat Chemical Co,, Ltd, indicated that
* . GCBE with 0.5% and 1% reduced visceral fat content and body weight
*. Caffeine and chlorogenic acid showed a tendency to reduce visceral fat and body weight
*. Oral administration of GCBE (100 and 200 mg/kg. day) for 13 days showed a tendency to reduce hepatic TG in mice
*. Chlorogenic acid (60 mg/kg. day) reduced hepatic TG level
The findings displayed a strong effect of coffee and its phytochemicals in promoting weight loss and reduced accumulation by inhibition of fat absorption and activation of fat metabolism in the liver.
Green coffee intake daily and regularly may be considered as a functional and integrated food against risk and treatment of obesity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Molecular mechanisms of the anti-obesity effect of bioactive compounds in tea and coffee by Pan MH1, Tung YC2, Yang G3, Li S3, Ho CT4.(PubMed)
(2) Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice by Choi BK1, Park SB2, Lee DR1, Lee HJ2, Jin YY3, Yang SH4, Suh JW5. (PubMed)
(3) Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice by Shimoda H1, Seki E, Aitani M.(PubMed)
#Turmeric Protects the Intestinal Mucosal Barrier Function through Multiple Pathways Against the Invasion of Pathogens, According to Studies
Kyle J. Norton
Intestinal mucosa processes a single cell layer of epithelial cells with a function to protect the intestine against invasive pathogens and ensure the function of the intestine in nutrient adsorption.
Biologically, the intestinal protection of the intestinal mucosal barrier function is associated with
*Bile and gastric acid produced in the liver and stomach that only aid digestion but kills microorganism
* Defensins secretory epithelial cells with a function to protect the intestines against bacteria, fungi, and many enveloped and nonenveloped viruses.
* Lysozyme is an enzyme that protects the intestine by causing the destruction of the cell walls of certain bacteria.
* Regenerating islet-derived protein 3 gammas (Reg3γ), an antibacterial lectin is a type of antimicrobial peptide found in the gut epithelial Paneth cells with a function to prevent microorganisms from coming into contact with the epithelial layer.
In other words, the intestinal mucosal barrier plays an essential role in the separation of the inside of the body from the outside environment, particularly in harmful microorganisms.
Dr. Oshima T the lead scientist in the examination of light junctions (TJs), the most important component for the construction of a constitutive barrier of epithelial cells that regulates the permeability of the barrier by tightly sealing the cell-cell junctions, wrote, "Gastrointestinal diseases including reflux esophagitis, inflammatory bowel disease, functional gastrointestinal disorders, and cancers may be regulated by these molecules, and disruption of their functions leads to chronic inflammatory conditions and chronic or progressive disease".
And, "regulation of the barrier function of epithelial cells by regulating the expression and localization of TJ proteins is a potential new target for the treatment of these diseases".
More precisely, by improving the intestinal mucosal barrier function, diseases associated with the gastrointestinal tract may be preventable.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential ingredient for the protection of the intestinal mucosal barrier, researchers examined the effects of curcumin's extensive pharmacological effects, on gastrointestinal diseases.
According to the analysis, curcumin exerted protective effects on the intestinal mucosal barrier through multiple pathways.
More precisely, curcumin protected the tissues of the intestinal mucosal barrier by
* By reducing the production of proinflammatory cytokines in orchestrating cell damage.
* By inhibiting the oxidative stress caused by overexpression of free radicals in facilitating the onset of chronic inflammation in the initiation of intestinal mucosal damage.
* By reducing levels of bacteria in the induction of infection that may weaken the function of the intestinal mucosal barrier.
Moreover, curcumin also protected the cells of intestinal mucosa against apoptosis.
In additional differentiation of the tested assays, researchers also found that curcumin also balances the ratio of gut microbiota associated with the regulation of intestinal microecology and intestinal immune response which plays a critical role in enhancing the intestinal mucosal barrier function.
Taken altogether, turmeric may be considered a supplement for the improvement of intestinal mucosal barrier function, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Advances in the research of the protective effect of curcumin on intestinal mucosal barrier function].
[Article in Chinese; Abstract available in Chinese from the publisher] by He D1, Wang S2, Hu H2, Yin HY2. (PubMed)
(2) Gastrointestinal mucosal barrier function and diseases by Oshima T1, Miwa H. (PubMed)
Intestinal mucosa processes a single cell layer of epithelial cells with a function to protect the intestine against invasive pathogens and ensure the function of the intestine in nutrient adsorption.
Biologically, the intestinal protection of the intestinal mucosal barrier function is associated with
*Bile and gastric acid produced in the liver and stomach that only aid digestion but kills microorganism
* Defensins secretory epithelial cells with a function to protect the intestines against bacteria, fungi, and many enveloped and nonenveloped viruses.
* Lysozyme is an enzyme that protects the intestine by causing the destruction of the cell walls of certain bacteria.
* Regenerating islet-derived protein 3 gammas (Reg3γ), an antibacterial lectin is a type of antimicrobial peptide found in the gut epithelial Paneth cells with a function to prevent microorganisms from coming into contact with the epithelial layer.
In other words, the intestinal mucosal barrier plays an essential role in the separation of the inside of the body from the outside environment, particularly in harmful microorganisms.
Dr. Oshima T the lead scientist in the examination of light junctions (TJs), the most important component for the construction of a constitutive barrier of epithelial cells that regulates the permeability of the barrier by tightly sealing the cell-cell junctions, wrote, "Gastrointestinal diseases including reflux esophagitis, inflammatory bowel disease, functional gastrointestinal disorders, and cancers may be regulated by these molecules, and disruption of their functions leads to chronic inflammatory conditions and chronic or progressive disease".
And, "regulation of the barrier function of epithelial cells by regulating the expression and localization of TJ proteins is a potential new target for the treatment of these diseases".
More precisely, by improving the intestinal mucosal barrier function, diseases associated with the gastrointestinal tract may be preventable.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential ingredient for the protection of the intestinal mucosal barrier, researchers examined the effects of curcumin's extensive pharmacological effects, on gastrointestinal diseases.
According to the analysis, curcumin exerted protective effects on the intestinal mucosal barrier through multiple pathways.
More precisely, curcumin protected the tissues of the intestinal mucosal barrier by
* By reducing the production of proinflammatory cytokines in orchestrating cell damage.
* By inhibiting the oxidative stress caused by overexpression of free radicals in facilitating the onset of chronic inflammation in the initiation of intestinal mucosal damage.
* By reducing levels of bacteria in the induction of infection that may weaken the function of the intestinal mucosal barrier.
Moreover, curcumin also protected the cells of intestinal mucosa against apoptosis.
In additional differentiation of the tested assays, researchers also found that curcumin also balances the ratio of gut microbiota associated with the regulation of intestinal microecology and intestinal immune response which plays a critical role in enhancing the intestinal mucosal barrier function.
Taken altogether, turmeric may be considered a supplement for the improvement of intestinal mucosal barrier function, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Advances in the research of the protective effect of curcumin on intestinal mucosal barrier function].
[Article in Chinese; Abstract available in Chinese from the publisher] by He D1, Wang S2, Hu H2, Yin HY2. (PubMed)
(2) Gastrointestinal mucosal barrier function and diseases by Oshima T1, Miwa H. (PubMed)
#Beetroot's Dietary Nitrate Inhibts #PlateletAggregation and #Hypertension Associated with the Risk of #CardiovascularDisease, Researchers Say
Kyle J. Norton
Compared to herbal medicine; food therapy may even take longer to ease symptoms, depending on the stage of the treatment which directly addresses the cause of the disease.
Adding a portion of beet to your daily diet may have a significant effect on improved blood circulation through anti-platelet aggregation and anti-hypertension activities, a recent and renowned study suggested.
Platelet aggregation is the natural reaction of the wound healing process of blood clotting in damage and injury of our body, to prevent infection and inflammation.
Beet, best known as the beetroot or garden beet and belongings to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.
According to the Barts & the London School of Medicine and Dentistry, dietary rich in nitrate vegetables or fruit, such as beet showed to exhibit vascular function in the promotion of blood vessel and blood circulation function, thus reducing the risk of CVD.
In healthy volunteers, ingestion of a dietary nitrate load (beetroot juice 500 mL), approximately 3 hours after, correlated with peak increases in plasma nitrite concentration showed a significant effect in attenuated platelet aggregation in response to collagen and adenosine diphosphate (ADP), in cell energy metabolism. And decreased plasma nitrite may block the decrease in blood pressure and abolished the inhibitory effects on platelet aggregation.
These findings suggested that regular drinking of dietary nitrate from food sources is necessary for the maintenance of a healthy heart through decreased platelet aggregation and reduced blood pressure.
In 2 randomized crossover studies each in 24 (12 of each sex) healthy subjects with orally administrated dietary nitrate (250 ml beetroot juice) or potassium nitrate capsules (KNO3, 8 mmol) vs placebo control on platelet reactivity, researchers found that the group treated with nitrate component shows a strong inhibition of platelet aggregation.
The study also demonstrated that inorganic nitrate ingestion, whether via diet or through supplementation, may have a gender preference in decreased platelet reactivity in healthy males but not females counterparts.
Dr. Velmurugan S, the lead author said, "Dietary nitrate (maybe a benefit) as an adjunct to current antiplatelet therapies to prevent atherothrombotic complications".
Furthermore, according to the review of the National Heart and Lung Institute, in vitro and in vivo, dietary nitrite exhibited cGMP in mediating the levels of platelet aggregation through an expression of nitric oxide actions,
And, in a model of thromboembolic radiolabeled platelet aggregation, injection of dietary nitrate or supplement showed a significantly inhibited platelet function in eNOS(-/-) mice.
Cyclic guanosine monophosphate (cGMP), a cyclic nucleotide plays both a stimulatory and an inhibitory role in platelet activation depending on concentration and timing.
NO also are best known for its function in regulating blood pressure and impaired NO bioactivity is an important component of hypertension
Collectively, beet with a high amount of dietary nitrate may be used as functional food combined with conventional treatment in reducing the risk of platelet aggregation and hypertension in the induction of CVD.
People who are taking anti-platelet aggregation medicine should consult with their doctors before applying large amounts of beet juice or juice with high concentrations of nitrate.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299
Sources
(1) Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite by Webb AJ1, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin N, MacAllister R, Hobbs AJ, Ahluwalia A.(PubMed)
(2) Antiplatelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence of sex by Velmurugan S1, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ, Poole A, Ahluwalia A.(PubMed)
(3) Role of inorganic nitrate and nitrite in driving nitric oxide-cGMP-mediated inhibition of platelet aggregation in vitro and in vivo by Apostoli GL1, Solomon A, Smallwood MJ, Winyard PG, Emerson M.(PubMed)
Compared to herbal medicine; food therapy may even take longer to ease symptoms, depending on the stage of the treatment which directly addresses the cause of the disease.
Adding a portion of beet to your daily diet may have a significant effect on improved blood circulation through anti-platelet aggregation and anti-hypertension activities, a recent and renowned study suggested.
Platelet aggregation is the natural reaction of the wound healing process of blood clotting in damage and injury of our body, to prevent infection and inflammation.
Beet, best known as the beetroot or garden beet and belongings to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.
According to the Barts & the London School of Medicine and Dentistry, dietary rich in nitrate vegetables or fruit, such as beet showed to exhibit vascular function in the promotion of blood vessel and blood circulation function, thus reducing the risk of CVD.
In healthy volunteers, ingestion of a dietary nitrate load (beetroot juice 500 mL), approximately 3 hours after, correlated with peak increases in plasma nitrite concentration showed a significant effect in attenuated platelet aggregation in response to collagen and adenosine diphosphate (ADP), in cell energy metabolism. And decreased plasma nitrite may block the decrease in blood pressure and abolished the inhibitory effects on platelet aggregation.
These findings suggested that regular drinking of dietary nitrate from food sources is necessary for the maintenance of a healthy heart through decreased platelet aggregation and reduced blood pressure.
In 2 randomized crossover studies each in 24 (12 of each sex) healthy subjects with orally administrated dietary nitrate (250 ml beetroot juice) or potassium nitrate capsules (KNO3, 8 mmol) vs placebo control on platelet reactivity, researchers found that the group treated with nitrate component shows a strong inhibition of platelet aggregation.
The study also demonstrated that inorganic nitrate ingestion, whether via diet or through supplementation, may have a gender preference in decreased platelet reactivity in healthy males but not females counterparts.
Dr. Velmurugan S, the lead author said, "Dietary nitrate (maybe a benefit) as an adjunct to current antiplatelet therapies to prevent atherothrombotic complications".
Furthermore, according to the review of the National Heart and Lung Institute, in vitro and in vivo, dietary nitrite exhibited cGMP in mediating the levels of platelet aggregation through an expression of nitric oxide actions,
And, in a model of thromboembolic radiolabeled platelet aggregation, injection of dietary nitrate or supplement showed a significantly inhibited platelet function in eNOS(-/-) mice.
Cyclic guanosine monophosphate (cGMP), a cyclic nucleotide plays both a stimulatory and an inhibitory role in platelet activation depending on concentration and timing.
NO also are best known for its function in regulating blood pressure and impaired NO bioactivity is an important component of hypertension
Collectively, beet with a high amount of dietary nitrate may be used as functional food combined with conventional treatment in reducing the risk of platelet aggregation and hypertension in the induction of CVD.
People who are taking anti-platelet aggregation medicine should consult with their doctors before applying large amounts of beet juice or juice with high concentrations of nitrate.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299
Sources
(1) Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite by Webb AJ1, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin N, MacAllister R, Hobbs AJ, Ahluwalia A.(PubMed)
(2) Antiplatelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence of sex by Velmurugan S1, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ, Poole A, Ahluwalia A.(PubMed)
(3) Role of inorganic nitrate and nitrite in driving nitric oxide-cGMP-mediated inhibition of platelet aggregation in vitro and in vivo by Apostoli GL1, Solomon A, Smallwood MJ, Winyard PG, Emerson M.(PubMed)
#Coffee and #CoffeeCaffeine Increase the Life Expectancy by Reducing the #GeneticTelomeres Lengths Much Slower
Kyle J. Norton
Intake of coffee may have a profound effect in strengthening the telomere length, a biomarker of living longer, some researchers suggested.
The results of the investigation based on the medical guideline and criteria were carried out by some universities, including the National Cancer Institute and Brigham and Women's Hospital, and Harvard Medical School.
Coffee, second to tea consumption, is a popular and social beverage all over the world, particularly in the West, made from roasted beans from the Coffea plant, native to tropical Africa and Madagascar.
In a cross-sectional association between coffee consumption and telomere length in 4780 women, using the data from the Nurses' Health Study (NHS) from a prospective cohort study of female nurses began in 1976 with relative telomere length measured in peripheral blood leukocytes by the quantitative real-time polymerase chain reaction, after adjusting to other risk factors, researchers found that
* Higher total coffee use was significantly associated with longer telomeres compared to non-drinkers.
* Intake of 2 to <3 and ≥3 cups of coffee/d showed a relative ratio of 1.29 and 1.36, respectively.
* Telomere length was associated linearly with caffeine consumption from all dietary sources
The findings showed a strong indication of a correlation between coffee caffeine intake and the length of telomeres among female nurses.
Dr. Liu JJ, the lead author said, " ... better understand the influence of coffee consumption on telomeres, which may uncover new knowledge of how coffee consumption affects health and longevity".
Furthermore, in the differentiation to re-confirm the effects of coffee drinking on increased life expectancy, Brigham Young University also conducted a study obtained data to examine the coffee longevity efficacy from 5826 adults from the National Health and Nutrition Examination Survey (NHANES) cross-sectionally,
In a total of 5826 adults, using the quantitative polymerase chain reaction method, telomere length compared to standard reference DNA, after adjusting to other risk factors, including age, gender, race, marital status, education, housing, smoking, BMI, physical activity, alcohol use,.. researchers showed that
* Caffeine consumption was inversely related to telomere length.
* For each 100 mg of caffeine consumed, telomeres were 35.4 base pairs shorter.
* For each 100 mg of caffeine consumed among coffee drinkers only, telomeres were 36.7 base pairs shorter.
* Among non-coffee drinkers only, 40.0 base pairs are shorter.
Compared to nondrinker {(40.0 base pairs shorter), coffee caffeine( 36.7 base pairs shorter), and caffeine( 35.4 base pairs shorter)} coffee intake expressed a positive effect in reduced genetic telomeres lengths much slower.
In other words, coffee caffeine drinkers have had a longer life expectancy compared to only coffee or caffeine drinkers and nondrinkers
Taking together, coffee (regardless caffeinated or not and the number of cups intake per day) expressed a significant effect in enhanced longevity through modulating the DNA implication of living longer in both genders.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299
Sources
(1) Coffee Consumption Is Positively Associated with Longer Leukocyte Telomere Length in the Nurses' Health Study by Liu JJ1, Crous-Bou M2, Giovannucci E3, De Vivo I4. (PubMed)
(2) Caffeine consumption and telomere length in men and women of the National Health and Nutrition Examination Survey (NHANES) by Tucker LA1.(PubMed)
Intake of coffee may have a profound effect in strengthening the telomere length, a biomarker of living longer, some researchers suggested.
The results of the investigation based on the medical guideline and criteria were carried out by some universities, including the National Cancer Institute and Brigham and Women's Hospital, and Harvard Medical School.
Coffee, second to tea consumption, is a popular and social beverage all over the world, particularly in the West, made from roasted beans from the Coffea plant, native to tropical Africa and Madagascar.
In a cross-sectional association between coffee consumption and telomere length in 4780 women, using the data from the Nurses' Health Study (NHS) from a prospective cohort study of female nurses began in 1976 with relative telomere length measured in peripheral blood leukocytes by the quantitative real-time polymerase chain reaction, after adjusting to other risk factors, researchers found that
* Higher total coffee use was significantly associated with longer telomeres compared to non-drinkers.
* Intake of 2 to <3 and ≥3 cups of coffee/d showed a relative ratio of 1.29 and 1.36, respectively.
* Telomere length was associated linearly with caffeine consumption from all dietary sources
The findings showed a strong indication of a correlation between coffee caffeine intake and the length of telomeres among female nurses.
Dr. Liu JJ, the lead author said, " ... better understand the influence of coffee consumption on telomeres, which may uncover new knowledge of how coffee consumption affects health and longevity".
Furthermore, in the differentiation to re-confirm the effects of coffee drinking on increased life expectancy, Brigham Young University also conducted a study obtained data to examine the coffee longevity efficacy from 5826 adults from the National Health and Nutrition Examination Survey (NHANES) cross-sectionally,
In a total of 5826 adults, using the quantitative polymerase chain reaction method, telomere length compared to standard reference DNA, after adjusting to other risk factors, including age, gender, race, marital status, education, housing, smoking, BMI, physical activity, alcohol use,.. researchers showed that
* Caffeine consumption was inversely related to telomere length.
* For each 100 mg of caffeine consumed, telomeres were 35.4 base pairs shorter.
* For each 100 mg of caffeine consumed among coffee drinkers only, telomeres were 36.7 base pairs shorter.
* Among non-coffee drinkers only, 40.0 base pairs are shorter.
Compared to nondrinker {(40.0 base pairs shorter), coffee caffeine( 36.7 base pairs shorter), and caffeine( 35.4 base pairs shorter)} coffee intake expressed a positive effect in reduced genetic telomeres lengths much slower.
In other words, coffee caffeine drinkers have had a longer life expectancy compared to only coffee or caffeine drinkers and nondrinkers
Taking together, coffee (regardless caffeinated or not and the number of cups intake per day) expressed a significant effect in enhanced longevity through modulating the DNA implication of living longer in both genders.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299
Sources
(1) Coffee Consumption Is Positively Associated with Longer Leukocyte Telomere Length in the Nurses' Health Study by Liu JJ1, Crous-Bou M2, Giovannucci E3, De Vivo I4. (PubMed)
(2) Caffeine consumption and telomere length in men and women of the National Health and Nutrition Examination Survey (NHANES) by Tucker LA1.(PubMed)
#Herbal #Devilsclaw Inhibits Diseases through Iits Effects on Cytokines and GrowthFactors, Researchers Show
Kyle J. Norton
Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.
Truly, the main focus of inflammation is to repair damage and injury.
Most cases of infection associated with inflammation are stopped at the acute phase. The wound or injury is slowly recovered.
However, overexpression of inflammatory cytokines in most cases can cause improper healing with scar formation or the death of nearby cells.
Any inflammation that lasts more than 8 weeks is considered chronic inflammation.
Believe it or not, worldwide, 3 of 5 death are results from chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes.
In the US, chronic inflammatory diseases affect more than 50 million Americans each year.
Diseases associated with low-grade inflammation include diabetes and cardiovascular.
Conventionally, Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common medical drugs such as aspirin. ibuprofen in reducing inflammation associated with pain-relieving.
On finding a natural ingredient for the prevention and treatment of liver diseases, scientists investigated the prepared an extract of Euphrasia officinalis, a traditional folk medicine, to synthesize gold nanoparticles (EO-AuNPs) anti-inflammatory effects on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages.
Devil's claw also known as the wood spider, is a plant of genus Harpagophytum in the family of Pedaliaceae, native to South Africa.
The plant has been used as an herb in traditional and herbal medicine to treat fever, rheumatoid arthritis, skin, gallbladder, pancreas, stomach and kidney conditions, etc.
According to tested analysis, the successful synthesis of AuNPs by E. officinalis showed significant anti-inflammatory activities detected by a model of LPS-induced upregulation of inflammatory mediators and cytokines.
More precisely, AuNPs by E. officinalis inhibited the levels of nitric oxide (NO), nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), IL-1β, and IL-6 in RAW 264.7 cells.
Furthermore, EO-AuNPs exhibited little cytotoxicity in RAW 264.7 cells at 100 µg/mL concentration after 24 hours.
Pretreatment with EO-AuNPs also significantly reduced the phosphorylation and degradation of inhibitor kappa B-alpha and inhibited the nuclear translocation of NF-κB p65 involved the production of pro-inflammatory cytokines.
Additionally, EO-AuNPs suppressed LPS-stimulated inflammation by blocking the activation of JAK/STAT pathway associated with cytokines and growth factors.
Based on the results, researchers suggest, "The synthesized EO-AuNPs showed anti-inflammatory activity in LPS-induced RAW 264.7 cells, suggesting they may be potential candidates for treating inflammatory-mediated diseases".
Taken altogether, Dandelion may be considered an anti-inflammatory remedy, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green synthesis of gold nanoparticles using Euphrasia officinalisleaf extract to inhibit lipopolysaccharide-induced inflammation through NF-κB and JAK/STAT pathways in RAW 264.7 macrophages by Liu Y1, Kim S2, Kim YJ1,2, Perumalsamy H2, Lee S3, Hwang E4, Yi TH. (PubMed)
Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.
Truly, the main focus of inflammation is to repair damage and injury.
Most cases of infection associated with inflammation are stopped at the acute phase. The wound or injury is slowly recovered.
However, overexpression of inflammatory cytokines in most cases can cause improper healing with scar formation or the death of nearby cells.
Any inflammation that lasts more than 8 weeks is considered chronic inflammation.
Believe it or not, worldwide, 3 of 5 death are results from chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes.
In the US, chronic inflammatory diseases affect more than 50 million Americans each year.
Diseases associated with low-grade inflammation include diabetes and cardiovascular.
Conventionally, Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common medical drugs such as aspirin. ibuprofen in reducing inflammation associated with pain-relieving.
On finding a natural ingredient for the prevention and treatment of liver diseases, scientists investigated the prepared an extract of Euphrasia officinalis, a traditional folk medicine, to synthesize gold nanoparticles (EO-AuNPs) anti-inflammatory effects on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages.
Devil's claw also known as the wood spider, is a plant of genus Harpagophytum in the family of Pedaliaceae, native to South Africa.
The plant has been used as an herb in traditional and herbal medicine to treat fever, rheumatoid arthritis, skin, gallbladder, pancreas, stomach and kidney conditions, etc.
According to tested analysis, the successful synthesis of AuNPs by E. officinalis showed significant anti-inflammatory activities detected by a model of LPS-induced upregulation of inflammatory mediators and cytokines.
More precisely, AuNPs by E. officinalis inhibited the levels of nitric oxide (NO), nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), IL-1β, and IL-6 in RAW 264.7 cells.
Furthermore, EO-AuNPs exhibited little cytotoxicity in RAW 264.7 cells at 100 µg/mL concentration after 24 hours.
Pretreatment with EO-AuNPs also significantly reduced the phosphorylation and degradation of inhibitor kappa B-alpha and inhibited the nuclear translocation of NF-κB p65 involved the production of pro-inflammatory cytokines.
Additionally, EO-AuNPs suppressed LPS-stimulated inflammation by blocking the activation of JAK/STAT pathway associated with cytokines and growth factors.
Based on the results, researchers suggest, "The synthesized EO-AuNPs showed anti-inflammatory activity in LPS-induced RAW 264.7 cells, suggesting they may be potential candidates for treating inflammatory-mediated diseases".
Taken altogether, Dandelion may be considered an anti-inflammatory remedy, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green synthesis of gold nanoparticles using Euphrasia officinalisleaf extract to inhibit lipopolysaccharide-induced inflammation through NF-κB and JAK/STAT pathways in RAW 264.7 macrophages by Liu Y1, Kim S2, Kim YJ1,2, Perumalsamy H2, Lee S3, Hwang E4, Yi TH. (PubMed)
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