Kyle J. Norton
About 5-8% of all people over the age of 65 have some form of dementia, and these numbers double every five years above that age.
Dementia is the loss of mental ability that is severe enough to interfere with people's everyday life.
And Alzheimer's disease is the most common type of dementia in aging people.
According to The University of Manchester, an unhealthy diet with high-fat consumption is associated with an increased risk of neuroinflammation causing both neuropathology and memory impairments in an animal model(15).
In the study conducted by Ichinomiya City Hospital, Ichinomiya, Japan, Dr. Ukai K, and Mizuno Y. said, " Physical complications that occurred in our ward in the 12 months from April 2007 to March 2008 were recorded. Our ward has 50 beds and, over the 12 months, the average occupancy rate was approximately 90%. We subdivided physical complications into two categories: (i) serious emergencies occurring in the ward with a possible high risk of mortality within a few days (e.g. pneumonia and upper airway obstruction); and (ii) life-threatening complications arising in the ward that required diagnosis and treatment by specialists from other medical departments (e.g. bone fracture and cancer)"(10).
The serious complications
1. Pneumonia
In the study of Beth Israel Deaconess Medical Center, Boston, Massachusetts, Dr. Givens JL showed that Pneumonia is common among patients with advanced dementia, especially toward the end of life.
Whether antimicrobial treatment improves survival or comfort is not well understood.
The objective of this study was to examine the effect of antimicrobial treatment for suspected pneumonia on survival and comfort in patients with advanced dementia. (11)
2. Obstructive Sleep Apnea Syndrome (OSAS)
The prevalence of OSAS increases with aging, occurring in up to 25% of older adults and up to 48% in patients with Alzheimer's disease. OSAS causes hypoxia, fragmented sleep, daytime sleepiness, cognitive dysfunction, functional decline, and brain damage resulting from reduced cerebral blood flow, ischemic brain lesions, microvascular reactivity, white matter lesions, and grey matter loss(12)
3. Bone fracture
In the study to investigate the relationship between bone mass and dementia in elderly hip fracture patients from areas with different aluminum concentrations in water supplies to determine researchers found that high concentrations of aluminum in the drinking water and the negative calcium balance are age-related osteoporosis together predispose to senile dementia. (13)
4. Urinary incontinence
Urinary incontinence may require the insertion of a urinary catheter, which is known to increase the risk of UTIs.
Urinary incontinence is a common problem in dementia. Almost invariably, the person with dementia will develop incontinence as the disease progresses.
However, the primary reasons for incontinence are often not because of any significant pathology in the urinary system. Rather, it is due to factors outside the urinary system. (14)
5. Venous thromboembolism
In the study to assess 37988 patients of whom 1316 (3.5%) had dementia, venous thromboembolism (VTE) patients with dementia had a high incidence of fatal pulmonary embolism (PE) and fatal bleeding.
In those initially presenting with PE, the risk of dying of PE far outweighed that of fatal bleeding.
And, in patients presenting with DVT alone, the risk of fatal PE was lower than that of fatal bleeding. (15).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources(10) http://www.ncbi.nlm.nih.gov/pubmed/20377817
(11) http://www.ncbi.nlm.nih.gov/pubmed/20625013
(12) http://www.ncbi.nlm.nih.gov/pubmed/20739254
(13) http://www.ncbi.nlm.nih.gov/pubmed/3239502
(14) http://www.ncbi.nlm.nih.gov/pubmed/16642241
(15) http://www.ncbi.nlm.nih.gov/pubmed/22374336
(16) https://www.ncbi.nlm.nih.gov/pubmed/24630364
Sunday, 9 July 2023
The Anti- #CervicalCancer #Fruits and #Veggies, According to Studies
Kyle J. Norton
The cervix is the lower part of the uterus that opens at the top of the vagina.
The cervix acts as a transition area for the vaginal lining (squamous epithelium) to change to uterus type (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus.
Cervical cancer is a malignant neoplasm of the cervix uteri or cervical area caused by abnormal cell growth with an alternation of cells' DNA.
At the later stage, the cancerous cells may travel a distance away from the cervix to infect other healthy organs and tissue.
According to the statistic, every year, approximately,13,000 women in the United States are diagnosed with invasive cervical cancer and 4,170 have died from the disease.
Women between the ages of 35 and 44. are associated with a substantially increased risk of cervical cancer compared to only 15% in women over age 65.
According to cancer.net, in the early stage of cervical cancer, patients may experience some mild symptoms of blood spots or light bleeding between or following periods, and longer and heavier menstrual bleeding.
If you experience some of the symptoms above, please let your family doctor knows. Early diagnosed
is associated closely with 100% of the survival rate.
In the later stage, patients may experience symptoms of bleeding after intercourse, douching, or a pelvic examination...........and unexplained, persistent pelvic and/or back pain. If you develop the above symptoms, please see your doctor immediately.
The American cancer associate suggested that women with genetic mutation and infected by human papillomavirus (HPV) become aggressive in the induced production of proteins known as E6 and E7 which turn off some tumor suppressor genes. maybe the cause of cervical cancer.
Please note that most women with HPV don’t get cervical cancer
Risk factors besides HPV also include immune system deficiency, herpes, smoking, age. group ... use of oral contraceptives, and exposure to diethylstilbestrol (DES).
The risk of cervical cancer is also higher in Hispanic women followed by African-Americans, Asians and Pacific Islanders, and whites(a).
Depending on the stage and grade of cancer, if the cancer is found in the early stage, a hysterectomy may not be needed.
Others, after surgery, may require chemotherapy including Cisplatin, Fluorouracil (5-FU), Mitomycin, Paclitaxel, Ifosfamide, Carboplatin, Bevacizumab, and radiotherapy if necessary,
All these chemo-drugs have been known to induce serious side effects
Epidemiological studies strongly suggested that a healthy and balanced diet improved serum levels of antioxidants may reduce cervical neoplasia risk(b)(c)
Foods have been found effective in reduced risk and treatment of cervical cancer., include
1. Cruciferous vegetables
Cruciferous vegetables are a group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli, etc.
Isothiocyanates, a major chemical constituent found in Cruciferous vegetables, inhibited the cell viability of human cervical cancer cells, through improvement of antioxidant status(1).
β-Phenylethyl isothiocyanate (PEITC). induced apoptosis to inhibit cell proliferation in human cervical cancer cell lines (HEp-2 and KB), through increased expression of the death receptors (DR4 and DR5) and cleaved caspase-3(2).
Other chemical compounds, such as I3C (indole-3-carbinol) and DIM (diindolylmethane) found in all types of cruciferous vegetables, demonstrated exceptional anti-cancer effects against hormone-responsive cancers such as ovarian cancers(3).
Some researchers suggested that isothiocyanates and indoles through the intake of cruciferous vegetables may decrease cancer risk, but the protective effects may be influenced by individual genetic variation (polymorphisms) in the metabolism and elimination of isothiocyanates from the body.
And in some instances, long-term exposure to sulforaphane and indole-3-carbinol (I3C), may have a negative implication in the treatment of a variety of anticarcinogenic mechanisms(4).
2. Tomato
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America.
Because of its health benefits, the tomato is grown worldwide for commercial purposes and often in the greenhouse.
Glycoalkaloid-rich green tomato extracts, according to the Seowon University inhibited proliferation of HeLa in cervical carcinoma cells through inactivation(5).
Dr. Ferguson LR, in the study of prospects for cancer prevention, suggested that fruit and vegetable servings with a total of a minimum of five each day, particularly in some specific fruits and vegetables (e.g., tomato, broccoli, onions) may have strong benefits against individual cancer types(6).
But, the reviews of FDA in 2004 studies which indicated an inverse association between tomato and/or lycopene intake and the risk of some types of cancer, suggested that there is no credible evidence for an association between tomato consumption and a reduced risk of lung, colorectal, breast, cervical, or endometrial cancer(7).
3. Garlic
Garlic is a natural superfood healer for its natural antibiotic with antiviral, antifungal, anticoagulant, and antiseptic properties.
Diallyl sulfide (DAS), a chemical component of garlic-induced mitochondrial dysfunction, caused the release of cytochrome c for causing apoptosis in human cervical cancer Ca Ski cells(8) and cell cycle arrest and apoptosis through the p53, caspase- and mitochondria-dependent pathways in HeLa human cervical cancer cells(9).
The Defense Food Research Laboratory study indicated that garlic exerted its anticarcinogenic effect(including cervical cancer) thrseveraler of mechanisms, including scavenging of radicals, increasing glutathione levels, and increasing the activities of enzymes(10).
In 3-methylcholanthrene (MCA)-induced carcinogenesis in the uterine cervix of virgin young adult Swiss albino mice study, researchers found that there is a significant decline in the incidence of carcinoma with oral administration of garlic at the dose level of 400 mg/kg body wt./day for 2 weeks before and 4 weeks following carcinogen thread insertion(11).
4. Ginger
Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Crude methanol and fractionated extract of the rhizomes of Alpinia pahangensis, a wild ginger distributed in the lowlands of Pahang, Malaysia, showed a potent cytotoxic effect against certain cancer cell lines, including human cervical cancer cell line, Ca Ski(12).
In human cervical epithelial carcinoma (HeLa), an aqueous extract of ginger (GAE) induced apoptosis of cancer cells by interacting directly with cellular microtubules and disrupting their structure(13).
Another study indicated that Benjakul [BEN], a composition of five plants: Piper Chaba fruit [PC], Piper sarmentosum root [PS], Piper interrupted stem [PI], Plumbago indica root [PL], and Zingiber officinale rhizome [ZO] in Thai herbal medicine, exerted potential cytotoxic activity against certain types of cancer cell line including cervical cancer cell line Hela(14).
5. Carrot
Carrots can grow to 3ft tall. It is a root vegetable with orange color normally, a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asia and Europe.
According to Aichi Cancer Center, frequent intakes of carrots are associated with decreased risk of cervical cancer(15).
The Shandong University study in assessing the risk of cervical cancer association of vitamin A, found abundantly in carrot (retinol, carotene, and other carotenoids) indicated that vitamin A intake and blood vitamin A levels are inversely associated with the risk of cervical cancer(16).
Others in the testing of concentrations of retinol and beta-carotene in serum samples taken from 113 women with cervical cancer, 32 with invasive and 81 with pre-invasive disease, and compared with those from 226 age-matched control women, scientists after taking into account other confounders suggested that there is a significantly reduced concentration of beta-carotene levels in women with pre-invasive disease compared to the control(17).
6. Dulse
Dulse is a red seaweed of genus Palmaria, belongings to Family Palmariaceae that grows attached to rocks by a "holdfast" in the North Atlantic and Northwest Pacific.
Seaweed is commonly used in Ireland and Atlantic Canada both as food and medicine. Today, dulses are now shipped around the globe for commercial benefits because of their health benefits
And fried dulses can be found in many health food stores or fish markets or can be ordered directly from local distributors.
Ryerson University study of the extracts from a variety of edible seaweeds showed a positive effect of dulse polyphenols in inhibited cell proliferation in the human cervical adenocarcinoma cell line (HeLa cells) through its antioxidant activity(18)(19).
Fucoxanthin found abundantly in dulse, in the study by Henan University, displayed autophagy-dependent cytotoxic effect in cervical cancer cell lines HeLa cells via inhibition of Akt/mTOR signaling pathway(20).
8. Strawberry
Strawberries are a genius of Fragaria × ananassa belongings to the family Rosaceae.
The fruits have been grown all over the world in a suitable climate for commercial profits and health benefits.
The studies of the effects of a variety of berry extracts in human cervical cancer (HeLa) cells, indicated that
* Tannin-rich fraction of procyanidins in the strawberry extract is most potent in comparison with other berries(21).
* The extract of Strawberry, Blueberry, and Raspberry extract. showed a positive effect in inhibited CaSki and SiHa cervical cancer cell lines(22).
9. Grape and Red wine
Grape is a woody vine of the genus Vitis, belongings to the family Vitaceae, native to southern Turkey.
Grape extracts were found to interact effectively with decaffeinated green tea extracts both in the inhibition of tNOX activity and in the inhibition of cancer cell growth(23).
Red and white wine polyphenols and resveratrol exerted higher cytotoxic activity against HeLabut white wine polyphenolic extract exhibited a significantly higher antiproliferative action on cancer cell lines than red wine extract(24).
10. Cactus Pear
Cactus pear also known as Prickly pear is a genus Opuntia, belongings to the family Cactaceae, native to Mexico.
Cactus pear extracts, in the study of immortalized ovarian and ovarian cancer cells (OVCA420, SKOV3), exhibited antiproliferative effects through a dramatic increase of reactive oxygen species (ROS),(25).
A study from the University of Arizona indicated that aqueous extracts of cactus pear significantly increased apoptosis and growth inhibition in both immortalized epithelial cells and cancer cells in a dose- and time-dependent manner through cell cycle arrest(26).
11. Vitis coignetiae Pulliat
Vitis coignetiae Pulliat also known as Yamabudo, Crimson Glory Vine, is the genus Viti, belongings to the family Vitaceae, native to the temperate climes of Asia.
It has been used as a healthy juice and wine because of the abundant polyphenols and anthocyanins.
Anthocyanins isolated from fruits of Vitis coignetiae Pulliat (AIMs), inhibited the invasion of HeLa cells in a dose-dependent manner,(26).
The stem extracts from Greek Vitis vinifera varieties of the total polyphenolic content (TPC) inhibited at low concentrations, the growth of HepG2 and HeLa cancer cells compared to those of seed extracts(27)(28).
Taken together, without going into reviews, the list of foods above may be potent in reducing the risk and treatment of cervical cancer. But further studies with large sample sizes and multi-centers are necessary to improve the validation of these claims.
However, some researchers argued that the role of diet and nutrition in the etiology of cervical cancer is not yet resolved(d).
And, the Catalan Institute of Oncology study showed statistically nonsignificant inverse associations were observed for leafy vegetables, root vegetables, garlic and onions, citrus fruits, vitamin C, vitamin E, and retinol for invasive squamous cervical cancer (ISC)(e).
As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Cerical cancer (American Cancer Society)
(b) Diet and serum micronutrients in relation to cervical neoplasia and cancer among low-income Brazilian women by Tomita LY1, Longatto Filho A, Costa MC, Andreoli MA, Villa LL, Franco EL, Cardoso MA; Brazilian Investigation into Nutrition and Cervical Cancer Prevention (BRINCA) Study Team. (PubMed)
(c) Associations of dietary dark-green and deep-yellow vegetables and fruits with cervical intraepithelial neoplasia: modification by smoking by Tomita LY1, Roteli-Martins CM, Villa LL, Franco EL, Cardoso MA; BRINCA Study Team. (PubMed)
(d) Diet and the risk of in situ cervical cancer among white women in the United States by Ziegler RG1, Jones CJ, Brinton LA, Norman SA, Mallin K, Levine RS, Lehman HF, Hamman RF, Trumble AC, Rosenthal JF, et al. (PubMed)
(e) Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study by González CA1, Travier N, Luján-Barroso L, Castellsagué X, Bosch FX, Roura E, Bueno-de-Mesquita HB, Palli D, Boeing H, Pala V, Sacerdote C, Tumino R, Panico S, Manjer J, Dillner J, Hallmans G, Kjellberg L, Sanchez MJ, Altzibar JM, Barricarte A, Navarro C, Rodriguez L, Allen N, Key TJ, Kaaks R, Rohrmann S, Overvad K, Olsen A, Tjønneland A, Munk C, Kjaer SK, Peeters PH, van Duijnhoven FJ, Clavel-Chapelon F, Boutron-Ruault MC, Trichopoulou A, Benetou V, Naska A, Lund E, Engeset D, Skeie G, Franceschi S, Slimani N, Rinaldi S, Riboli E.(PubMed)
(1) The anti-oxidant properties of isothiocyanates: a review by de Figueiredo SM1, Filho SA, Nogueira-Machado JA, Caligiorne RB. (PubMed)
(2) Effect of β-phenylethyl isothiocyanate from cruciferous vegetables on growth inhibition and apoptosis of cervical cancer cells through the induction of death receptors 4 and 5 by Huong le D1, Shim JH, Choi KH, Shin JA, Choi ES, Kim HS, Lee SJ, Kim SJ, Cho NP, Cho SD(PubMed)
(3) Chemopreventive properties of indole-3-carbinol, diindolylmethane and other constituents of cardamom against carcinogenesis by Acharya A1, Das I, Singh S, Saha T.(PubMed)
(4) Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis by Higdon JV1, Delage B, Williams DE, Dashwood RH. (PubMed)
(5) Changes in free amino acid, phenolic, chlorophyll, carotenoid, and glycoalkaloid contents in tomatoes during 11 stages of growth and inhibition of cervical and lung human cancer cells by green tomato extracts by Choi SH1, Lee SH, Kim HJ, Lee IS, Kozukue N, Levin CE, Friedman M.(PubMed)
(6) Prospects for cancer prevention by Ferguson LR. (PubMed)
(7) The U.S. Food and Drug Administration's evidence-based review for qualified health claims: tomatoes, lycopene, and cancer by Kavanaugh CJ1, Trumbo PR, Ellwood KC. (PubMed)
(8) Diallyl sulfide promotes cell-cycle arrest through the p53 expression and triggers induction of apoptosis via caspase- and mitochondria-dependent signaling pathways in human cervical cancer Ca Ski cells by Chiu TH1, Lan KY, Yang MD, Lin JJ, Hsia TC, Wu CT, Yang JS, Chueh FS, Chung JG.(PubMed)
(9) Diallyl sulfide induces cell cycle arrest and apoptosis in HeLa human cervical cancer cells through the p53, caspase- and mitochondria-dependent pathways by Wu PP1, Chung HW, Liu KC, Wu RS, Yang JS, Tang NY, Lo C, Hsia TC, Yu CC, Chueh FS, Lin SS, Chung JG.(PubMed)
(10) Anticarcinogenic properties of garlic: a review by Khanum F1, Anilakumar KR, Viswanathan KR.(PubMed)
(11) Chemopreventive action of garlic on methylcholanthrene-induced carcinogenesis in the uterine cervix of mice by Hussain SP1, Jannu LN, Rao AR.(PubMed)
(12) Antioxidant potential, cytotoxic activity and total phenolic content of Alpinia pahangensis rhizomes by Phang CW1, Malek SN, Ibrahim H.(PubMed)
(13) Aqueous extract of ginger shows antiproliferative activity through disruption of microtubule network of cancer cells by Choudhury D1, Das A, Bhattacharya A, Chakrabarti G.(PubMed)
(14) In vitro cytotoxic activity of Benjakul herbal preparation and its active compounds against human lung, cervical and liver cancer cells by Ruangnoo S1, Itharat A, Sakpakdeejaroen I, Rattarom R, Tappayutpijam P, Pawa KK.(PubMed)
(15) [Hospital epidemiology--a comparative case control study of breast and cervical cancers].
[Article in Japanese] by Tajima K1, Hirose K, Ogawa H, Yoshida M, Ohta M.(PubMed)
(16) Vitamin A and risk of cervical cancer: a meta-analysis by Zhang X1, Dai B, Zhang B, Wang Z.(PubMed)
(17) Cancer of the cervix uteri and vitamin A by Harris RW, Forman D, Doll R, Vessey MP, Wald NJ.(PubMed)
(18) Antioxidant and antiproliferative activities of extracts from a variety of edible seaweeds by Yuan YV1, Walsh NA.(PubMed)
(19) Extracts from dulse (Palmaria palmata) are effective antioxidants and inhibitors of cell proliferation in vitro. by Yuan YV1, Carrington MF, Walsh NA.(PubMed)
(20) Essential role of autophagy in fucoxanthin-induced cytotoxicity to human epithelial cervical cancer HeLa cells by Hou LL1, Gao C, Chen L, Hu GQ, Xie SQ.(PubMed)
(21) Berry extracts exert different antiproliferative effects against cervicaland colon cancer cells grown in vitro by McDougall GJ1, Ross HA, Ikeji M, Stewart D.(PubMed)
(22) Anticarcinogenic Activity of Strawberry, Blueberry, and Raspberry Extracts to Breast and Cervical Cancer Cells. by Wedge DE1, Meepagala KM, Magee JB, Smith SH, Huang G, Larcom LL.(PubMed)
(23) Anticancer activity of grape and grape skin extracts alone and combined with green tea infusions by Morré DM1, Morré DJ.(PubMed)
(24) Cytotoxic effect of wine polyphenolic extracts and resveratrol against human carcinoma cells and normal peripheral blood mononuclear cells by Matić I1, Zizak Z, Simonović M, Simonović B, Godevac D, Savikin K, Juranić Z.(PubMed)
(25) Cactus pear extracts induce reactive oxygen species production and apoptosis in ovarian cancer cells by Feugang JM1, Ye F, Zhang DY, Yu Y, Zhong M, Zhang S, Zou C.(PubMed)
(26) Cactus pear: a natural product in cancer chemoprevention by Zou DM1, Brewer M, Garcia F, Feugang JM, Wang J, Zang R, Liu H, Zou C.(PubMed)
(27) Anthocyanins from Vitis coignetiae Pulliat Inhibit Cancer Invasion and Epithelial-Mesenchymal Transition, but These Effects Can Be Attenuated by Tumor Necrosis Factor in Human Uterine Cervical Cancer HeLa Cells by Lu JN1, Lee WS, Yun JW, Kim MJ, Kim HJ, Kim DC, Jeong JH, Choi YH, Kim GS, Ryu CH, Shin SC.(PubMed)
(28) Assessment of polyphenolic content, antioxidant activity, protection against ROS-induced DNA damage and anticancer activity of Vitis vinifera stem extracts by Apostolou A1, Stagos D, Galitsiou E, Spyrou A, Haroutounian S, Portesis N, Trizoglou I, Wallace Hayes A, Tsatsakis AM, Kouretas D.
The cervix is the lower part of the uterus that opens at the top of the vagina.
The cervix acts as a transition area for the vaginal lining (squamous epithelium) to change to uterus type (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus.
Cervical cancer is a malignant neoplasm of the cervix uteri or cervical area caused by abnormal cell growth with an alternation of cells' DNA.
At the later stage, the cancerous cells may travel a distance away from the cervix to infect other healthy organs and tissue.
According to the statistic, every year, approximately,13,000 women in the United States are diagnosed with invasive cervical cancer and 4,170 have died from the disease.
Women between the ages of 35 and 44. are associated with a substantially increased risk of cervical cancer compared to only 15% in women over age 65.
According to cancer.net, in the early stage of cervical cancer, patients may experience some mild symptoms of blood spots or light bleeding between or following periods, and longer and heavier menstrual bleeding.
If you experience some of the symptoms above, please let your family doctor knows. Early diagnosed
is associated closely with 100% of the survival rate.
In the later stage, patients may experience symptoms of bleeding after intercourse, douching, or a pelvic examination...........and unexplained, persistent pelvic and/or back pain. If you develop the above symptoms, please see your doctor immediately.
The American cancer associate suggested that women with genetic mutation and infected by human papillomavirus (HPV) become aggressive in the induced production of proteins known as E6 and E7 which turn off some tumor suppressor genes. maybe the cause of cervical cancer.
Please note that most women with HPV don’t get cervical cancer
Risk factors besides HPV also include immune system deficiency, herpes, smoking, age. group ... use of oral contraceptives, and exposure to diethylstilbestrol (DES).
The risk of cervical cancer is also higher in Hispanic women followed by African-Americans, Asians and Pacific Islanders, and whites(a).
Depending on the stage and grade of cancer, if the cancer is found in the early stage, a hysterectomy may not be needed.
Others, after surgery, may require chemotherapy including Cisplatin, Fluorouracil (5-FU), Mitomycin, Paclitaxel, Ifosfamide, Carboplatin, Bevacizumab, and radiotherapy if necessary,
All these chemo-drugs have been known to induce serious side effects
Epidemiological studies strongly suggested that a healthy and balanced diet improved serum levels of antioxidants may reduce cervical neoplasia risk(b)(c)
Foods have been found effective in reduced risk and treatment of cervical cancer., include
1. Cruciferous vegetables
Cruciferous vegetables are a group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli, etc.
Isothiocyanates, a major chemical constituent found in Cruciferous vegetables, inhibited the cell viability of human cervical cancer cells, through improvement of antioxidant status(1).
β-Phenylethyl isothiocyanate (PEITC). induced apoptosis to inhibit cell proliferation in human cervical cancer cell lines (HEp-2 and KB), through increased expression of the death receptors (DR4 and DR5) and cleaved caspase-3(2).
Other chemical compounds, such as I3C (indole-3-carbinol) and DIM (diindolylmethane) found in all types of cruciferous vegetables, demonstrated exceptional anti-cancer effects against hormone-responsive cancers such as ovarian cancers(3).
Some researchers suggested that isothiocyanates and indoles through the intake of cruciferous vegetables may decrease cancer risk, but the protective effects may be influenced by individual genetic variation (polymorphisms) in the metabolism and elimination of isothiocyanates from the body.
And in some instances, long-term exposure to sulforaphane and indole-3-carbinol (I3C), may have a negative implication in the treatment of a variety of anticarcinogenic mechanisms(4).
2. Tomato
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America.
Because of its health benefits, the tomato is grown worldwide for commercial purposes and often in the greenhouse.
Glycoalkaloid-rich green tomato extracts, according to the Seowon University inhibited proliferation of HeLa in cervical carcinoma cells through inactivation(5).
Dr. Ferguson LR, in the study of prospects for cancer prevention, suggested that fruit and vegetable servings with a total of a minimum of five each day, particularly in some specific fruits and vegetables (e.g., tomato, broccoli, onions) may have strong benefits against individual cancer types(6).
But, the reviews of FDA in 2004 studies which indicated an inverse association between tomato and/or lycopene intake and the risk of some types of cancer, suggested that there is no credible evidence for an association between tomato consumption and a reduced risk of lung, colorectal, breast, cervical, or endometrial cancer(7).
3. Garlic
Garlic is a natural superfood healer for its natural antibiotic with antiviral, antifungal, anticoagulant, and antiseptic properties.
Diallyl sulfide (DAS), a chemical component of garlic-induced mitochondrial dysfunction, caused the release of cytochrome c for causing apoptosis in human cervical cancer Ca Ski cells(8) and cell cycle arrest and apoptosis through the p53, caspase- and mitochondria-dependent pathways in HeLa human cervical cancer cells(9).
The Defense Food Research Laboratory study indicated that garlic exerted its anticarcinogenic effect(including cervical cancer) thrseveraler of mechanisms, including scavenging of radicals, increasing glutathione levels, and increasing the activities of enzymes(10).
In 3-methylcholanthrene (MCA)-induced carcinogenesis in the uterine cervix of virgin young adult Swiss albino mice study, researchers found that there is a significant decline in the incidence of carcinoma with oral administration of garlic at the dose level of 400 mg/kg body wt./day for 2 weeks before and 4 weeks following carcinogen thread insertion(11).
4. Ginger
Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Crude methanol and fractionated extract of the rhizomes of Alpinia pahangensis, a wild ginger distributed in the lowlands of Pahang, Malaysia, showed a potent cytotoxic effect against certain cancer cell lines, including human cervical cancer cell line, Ca Ski(12).
In human cervical epithelial carcinoma (HeLa), an aqueous extract of ginger (GAE) induced apoptosis of cancer cells by interacting directly with cellular microtubules and disrupting their structure(13).
Another study indicated that Benjakul [BEN], a composition of five plants: Piper Chaba fruit [PC], Piper sarmentosum root [PS], Piper interrupted stem [PI], Plumbago indica root [PL], and Zingiber officinale rhizome [ZO] in Thai herbal medicine, exerted potential cytotoxic activity against certain types of cancer cell line including cervical cancer cell line Hela(14).
5. Carrot
Carrots can grow to 3ft tall. It is a root vegetable with orange color normally, a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asia and Europe.
According to Aichi Cancer Center, frequent intakes of carrots are associated with decreased risk of cervical cancer(15).
The Shandong University study in assessing the risk of cervical cancer association of vitamin A, found abundantly in carrot (retinol, carotene, and other carotenoids) indicated that vitamin A intake and blood vitamin A levels are inversely associated with the risk of cervical cancer(16).
Others in the testing of concentrations of retinol and beta-carotene in serum samples taken from 113 women with cervical cancer, 32 with invasive and 81 with pre-invasive disease, and compared with those from 226 age-matched control women, scientists after taking into account other confounders suggested that there is a significantly reduced concentration of beta-carotene levels in women with pre-invasive disease compared to the control(17).
6. Dulse
Dulse is a red seaweed of genus Palmaria, belongings to Family Palmariaceae that grows attached to rocks by a "holdfast" in the North Atlantic and Northwest Pacific.
Seaweed is commonly used in Ireland and Atlantic Canada both as food and medicine. Today, dulses are now shipped around the globe for commercial benefits because of their health benefits
And fried dulses can be found in many health food stores or fish markets or can be ordered directly from local distributors.
Ryerson University study of the extracts from a variety of edible seaweeds showed a positive effect of dulse polyphenols in inhibited cell proliferation in the human cervical adenocarcinoma cell line (HeLa cells) through its antioxidant activity(18)(19).
Fucoxanthin found abundantly in dulse, in the study by Henan University, displayed autophagy-dependent cytotoxic effect in cervical cancer cell lines HeLa cells via inhibition of Akt/mTOR signaling pathway(20).
8. Strawberry
Strawberries are a genius of Fragaria × ananassa belongings to the family Rosaceae.
The fruits have been grown all over the world in a suitable climate for commercial profits and health benefits.
The studies of the effects of a variety of berry extracts in human cervical cancer (HeLa) cells, indicated that
* Tannin-rich fraction of procyanidins in the strawberry extract is most potent in comparison with other berries(21).
* The extract of Strawberry, Blueberry, and Raspberry extract. showed a positive effect in inhibited CaSki and SiHa cervical cancer cell lines(22).
9. Grape and Red wine
Grape is a woody vine of the genus Vitis, belongings to the family Vitaceae, native to southern Turkey.
Grape extracts were found to interact effectively with decaffeinated green tea extracts both in the inhibition of tNOX activity and in the inhibition of cancer cell growth(23).
Red and white wine polyphenols and resveratrol exerted higher cytotoxic activity against HeLabut white wine polyphenolic extract exhibited a significantly higher antiproliferative action on cancer cell lines than red wine extract(24).
10. Cactus Pear
Cactus pear also known as Prickly pear is a genus Opuntia, belongings to the family Cactaceae, native to Mexico.
Cactus pear extracts, in the study of immortalized ovarian and ovarian cancer cells (OVCA420, SKOV3), exhibited antiproliferative effects through a dramatic increase of reactive oxygen species (ROS),(25).
A study from the University of Arizona indicated that aqueous extracts of cactus pear significantly increased apoptosis and growth inhibition in both immortalized epithelial cells and cancer cells in a dose- and time-dependent manner through cell cycle arrest(26).
11. Vitis coignetiae Pulliat
Vitis coignetiae Pulliat also known as Yamabudo, Crimson Glory Vine, is the genus Viti, belongings to the family Vitaceae, native to the temperate climes of Asia.
It has been used as a healthy juice and wine because of the abundant polyphenols and anthocyanins.
Anthocyanins isolated from fruits of Vitis coignetiae Pulliat (AIMs), inhibited the invasion of HeLa cells in a dose-dependent manner,(26).
The stem extracts from Greek Vitis vinifera varieties of the total polyphenolic content (TPC) inhibited at low concentrations, the growth of HepG2 and HeLa cancer cells compared to those of seed extracts(27)(28).
Taken together, without going into reviews, the list of foods above may be potent in reducing the risk and treatment of cervical cancer. But further studies with large sample sizes and multi-centers are necessary to improve the validation of these claims.
However, some researchers argued that the role of diet and nutrition in the etiology of cervical cancer is not yet resolved(d).
And, the Catalan Institute of Oncology study showed statistically nonsignificant inverse associations were observed for leafy vegetables, root vegetables, garlic and onions, citrus fruits, vitamin C, vitamin E, and retinol for invasive squamous cervical cancer (ISC)(e).
As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Cerical cancer (American Cancer Society)
(b) Diet and serum micronutrients in relation to cervical neoplasia and cancer among low-income Brazilian women by Tomita LY1, Longatto Filho A, Costa MC, Andreoli MA, Villa LL, Franco EL, Cardoso MA; Brazilian Investigation into Nutrition and Cervical Cancer Prevention (BRINCA) Study Team. (PubMed)
(c) Associations of dietary dark-green and deep-yellow vegetables and fruits with cervical intraepithelial neoplasia: modification by smoking by Tomita LY1, Roteli-Martins CM, Villa LL, Franco EL, Cardoso MA; BRINCA Study Team. (PubMed)
(d) Diet and the risk of in situ cervical cancer among white women in the United States by Ziegler RG1, Jones CJ, Brinton LA, Norman SA, Mallin K, Levine RS, Lehman HF, Hamman RF, Trumble AC, Rosenthal JF, et al. (PubMed)
(e) Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study by González CA1, Travier N, Luján-Barroso L, Castellsagué X, Bosch FX, Roura E, Bueno-de-Mesquita HB, Palli D, Boeing H, Pala V, Sacerdote C, Tumino R, Panico S, Manjer J, Dillner J, Hallmans G, Kjellberg L, Sanchez MJ, Altzibar JM, Barricarte A, Navarro C, Rodriguez L, Allen N, Key TJ, Kaaks R, Rohrmann S, Overvad K, Olsen A, Tjønneland A, Munk C, Kjaer SK, Peeters PH, van Duijnhoven FJ, Clavel-Chapelon F, Boutron-Ruault MC, Trichopoulou A, Benetou V, Naska A, Lund E, Engeset D, Skeie G, Franceschi S, Slimani N, Rinaldi S, Riboli E.(PubMed)
(1) The anti-oxidant properties of isothiocyanates: a review by de Figueiredo SM1, Filho SA, Nogueira-Machado JA, Caligiorne RB. (PubMed)
(2) Effect of β-phenylethyl isothiocyanate from cruciferous vegetables on growth inhibition and apoptosis of cervical cancer cells through the induction of death receptors 4 and 5 by Huong le D1, Shim JH, Choi KH, Shin JA, Choi ES, Kim HS, Lee SJ, Kim SJ, Cho NP, Cho SD(PubMed)
(3) Chemopreventive properties of indole-3-carbinol, diindolylmethane and other constituents of cardamom against carcinogenesis by Acharya A1, Das I, Singh S, Saha T.(PubMed)
(4) Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis by Higdon JV1, Delage B, Williams DE, Dashwood RH. (PubMed)
(5) Changes in free amino acid, phenolic, chlorophyll, carotenoid, and glycoalkaloid contents in tomatoes during 11 stages of growth and inhibition of cervical and lung human cancer cells by green tomato extracts by Choi SH1, Lee SH, Kim HJ, Lee IS, Kozukue N, Levin CE, Friedman M.(PubMed)
(6) Prospects for cancer prevention by Ferguson LR. (PubMed)
(7) The U.S. Food and Drug Administration's evidence-based review for qualified health claims: tomatoes, lycopene, and cancer by Kavanaugh CJ1, Trumbo PR, Ellwood KC. (PubMed)
(8) Diallyl sulfide promotes cell-cycle arrest through the p53 expression and triggers induction of apoptosis via caspase- and mitochondria-dependent signaling pathways in human cervical cancer Ca Ski cells by Chiu TH1, Lan KY, Yang MD, Lin JJ, Hsia TC, Wu CT, Yang JS, Chueh FS, Chung JG.(PubMed)
(9) Diallyl sulfide induces cell cycle arrest and apoptosis in HeLa human cervical cancer cells through the p53, caspase- and mitochondria-dependent pathways by Wu PP1, Chung HW, Liu KC, Wu RS, Yang JS, Tang NY, Lo C, Hsia TC, Yu CC, Chueh FS, Lin SS, Chung JG.(PubMed)
(10) Anticarcinogenic properties of garlic: a review by Khanum F1, Anilakumar KR, Viswanathan KR.(PubMed)
(11) Chemopreventive action of garlic on methylcholanthrene-induced carcinogenesis in the uterine cervix of mice by Hussain SP1, Jannu LN, Rao AR.(PubMed)
(12) Antioxidant potential, cytotoxic activity and total phenolic content of Alpinia pahangensis rhizomes by Phang CW1, Malek SN, Ibrahim H.(PubMed)
(13) Aqueous extract of ginger shows antiproliferative activity through disruption of microtubule network of cancer cells by Choudhury D1, Das A, Bhattacharya A, Chakrabarti G.(PubMed)
(14) In vitro cytotoxic activity of Benjakul herbal preparation and its active compounds against human lung, cervical and liver cancer cells by Ruangnoo S1, Itharat A, Sakpakdeejaroen I, Rattarom R, Tappayutpijam P, Pawa KK.(PubMed)
(15) [Hospital epidemiology--a comparative case control study of breast and cervical cancers].
[Article in Japanese] by Tajima K1, Hirose K, Ogawa H, Yoshida M, Ohta M.(PubMed)
(16) Vitamin A and risk of cervical cancer: a meta-analysis by Zhang X1, Dai B, Zhang B, Wang Z.(PubMed)
(17) Cancer of the cervix uteri and vitamin A by Harris RW, Forman D, Doll R, Vessey MP, Wald NJ.(PubMed)
(18) Antioxidant and antiproliferative activities of extracts from a variety of edible seaweeds by Yuan YV1, Walsh NA.(PubMed)
(19) Extracts from dulse (Palmaria palmata) are effective antioxidants and inhibitors of cell proliferation in vitro. by Yuan YV1, Carrington MF, Walsh NA.(PubMed)
(20) Essential role of autophagy in fucoxanthin-induced cytotoxicity to human epithelial cervical cancer HeLa cells by Hou LL1, Gao C, Chen L, Hu GQ, Xie SQ.(PubMed)
(21) Berry extracts exert different antiproliferative effects against cervicaland colon cancer cells grown in vitro by McDougall GJ1, Ross HA, Ikeji M, Stewart D.(PubMed)
(22) Anticarcinogenic Activity of Strawberry, Blueberry, and Raspberry Extracts to Breast and Cervical Cancer Cells. by Wedge DE1, Meepagala KM, Magee JB, Smith SH, Huang G, Larcom LL.(PubMed)
(23) Anticancer activity of grape and grape skin extracts alone and combined with green tea infusions by Morré DM1, Morré DJ.(PubMed)
(24) Cytotoxic effect of wine polyphenolic extracts and resveratrol against human carcinoma cells and normal peripheral blood mononuclear cells by Matić I1, Zizak Z, Simonović M, Simonović B, Godevac D, Savikin K, Juranić Z.(PubMed)
(25) Cactus pear extracts induce reactive oxygen species production and apoptosis in ovarian cancer cells by Feugang JM1, Ye F, Zhang DY, Yu Y, Zhong M, Zhang S, Zou C.(PubMed)
(26) Cactus pear: a natural product in cancer chemoprevention by Zou DM1, Brewer M, Garcia F, Feugang JM, Wang J, Zang R, Liu H, Zou C.(PubMed)
(27) Anthocyanins from Vitis coignetiae Pulliat Inhibit Cancer Invasion and Epithelial-Mesenchymal Transition, but These Effects Can Be Attenuated by Tumor Necrosis Factor in Human Uterine Cervical Cancer HeLa Cells by Lu JN1, Lee WS, Yun JW, Kim MJ, Kim HJ, Kim DC, Jeong JH, Choi YH, Kim GS, Ryu CH, Shin SC.(PubMed)
(28) Assessment of polyphenolic content, antioxidant activity, protection against ROS-induced DNA damage and anticancer activity of Vitis vinifera stem extracts by Apostolou A1, Stagos D, Galitsiou E, Spyrou A, Haroutounian S, Portesis N, Trizoglou I, Wallace Hayes A, Tsatsakis AM, Kouretas D.
The #NaturalRemedies that Detox Your Body's Organs For the #OptimalHealth, Researchers Find
Kyle J. Norton
The Western diet contains high saturated fat, trans fat, and other harmful substances such as sugar, caffeine, pesticides, and addictive substances, and less in fruits and vegetables.
These types of harmful substances are toxic.
Detoxification is a natural process of our body to maintain the proper function and protect our organs and tissues against toxicity by eliminating toxins accumulated.
When they fail, the toxic accumulations cause a disruption of hormone production, damage the body's detoxification organs and weaken the immune system, leading to hormone imbalance and many chronic illnesses consequently.
Some researchers suggested that overexpression of toxins may lead to an imbalance of the ratio of free radicals and antioxidants produced by the antioxidant enzymes of tissue, leading to oxidative stress in the induction of cytotoxicity.
Cytotoxicity not only damages healthy cells but also alternates cell DNA transcription, one of the major causes of cancer.
The natural remedies detox and nourish your Immune system, Brain, Liver, Kidney, Skin, Lungs, and Blood include
1. Garlic extract
Garlic extract is a widely used medication in the world with a proven record in preventing and treating heart disease, increasing circulation of blood flow, and protecting our kidneys and liver against injury and damage caused by ROS-inducing cytotoxicity.
According to a 2009 study by Tabriz University of Medical Sciences, the application of garlic extract in tested mice reserved liver toxicity caused by overdosing on acetaminophen in the induction of oxidative stress and depletion of the host antioxidants, such as glutathione (GSH)(1).
Dr. Anoush M, the lead scientist said, "Acetaminophen, the most commonly sold over-the-counter antipyretic analgesic, is capable of causing severe and sometimes fatal hepatic damage in humans and experimental animals".
The herb also strengthens our system's fight against the degeneration of our body.
2. Gotu Kola
Gotu Kola is also known as cetenlla asiatica with a strong effect in treating nervous system disorders caused by inflammation and improving alertness and memory.
According to the Inha University Hospital, the application of leaf extract exerted a significant activity in reduced oxidative stress induced by injection of dimethylnitrosamine‑induced liver injury in rats(2).
The results of these actions were attributed to the extract significantly decreasing the level of malondialdehyde and increasing the levels of host antioxidant enzymes, including superoxide dismutase, glutathione peroxidase, and catalase, and may have provided protection against the deleterious effects of reactive oxygen species.
In metal toxins accumulation by arsenic exposure (20 ppm in drinking water for 4 weeks) injection in tested rats, application of oral supplementation of Centella Asiatica (100, 200 or 300 mg kg(-1), orally once daily displayed a strong inhibition of delta-aminolevulinic acid dehydratase (ALAD) activity in induction of increased oxidized glutathione (GSSG) and thiobarbituric acid reactive substance (TBARS) levels(3).
Overexpression of ROS can lead to liver, kidney, and brain damage permanently(3).
These results suggested that Gotu Kola antitoxins in the liver, kidney, and blood effect(13) may be considered as a co-administration during chelation therapy with a thiol chelator(3).
With enormous antioxidant properties, Gotu kola can also rejuvenate the body against the forming of free radicals in induced early aging.
3. Astragalus
Astragalus is used in traditional Chinese medicine for strengthening our body in fighting against diseases and protecting cells from free radicals through its antioxidant activity.
Herbal medicine also is an excellent agent in the fight against virus and bacteria and restore our body's energy.
According to the Institute of Clinical Pharmacology, Anhui Medical University, extract isolated from the roots of P. lactifloruala and A. membranaceus demonstrated better hepatoprotective activity in compared to the application of individual herbs used separately(4), through antioxidant activity.
Furthermore, injection in animal models suggested that astragalus saponin extracts (AS) process strong kidneys protective in diabetic rats(5). through the reduction of renal pathological changes.
4. Bee Pollen
Bee pollen is said to contain all the essential components of life.
According to traditional herbal medicine, the herb process unified activity by correcting the deficiency, rebalancing nutrition, and improving our immune system as well as rejuvenating our body.
In concerns of Cisplatin (CP), after application to patients with an aim to cure cancers although it is effective in clinics, however, it could induce toxic effects, researchers at the Fujian Agriculture and Forestry University, conducted an experiment to test whether bee pollen, a natural compound, produced by honey bees has a potential inhibited expression of these toxic effects(6).
The results are so astonishing, the application of bee pollen extract (SCBPE) reversed the damage to the liver and kidney caused by Cisplatin (CP) by improving the antioxidant, anti-inflammatory, and anti-apoptotic capacity of the body.
Moreover, antioxidant-rich bee pollen also demonstrated a strong preventive effect against histological changes in the liver and cardiac blood vessels, abnormalities of lipid profile, and the levels of oxidized low-density lipoproteins (ox-LDL), asymmetric dimethylarginine (ADMA), angiotensin-converting enzyme (ACE), and angiotensin II (ANG II) caused by a high-fat diet in C57BL₆ mice(7).
5. Dock
The dock contains vitamin C and vitamin A.
The herbal medicine not only promotes a strong immune system but also dissolves heavy metal accumulated in our body and prevents muscular degeneration.
According to the Xi'an Jiaotong University Health Science Center, dihydromyricetin (DHM), a bioactive flavonoid component isolated from dock against lung injury and damage caused by injection of LPS(8).
6. Reishi Mushroom
Reishi Mushroom contains ganoderic acids with function in strengthening our immune system's fight against inflammation.
In the study to evaluate the antioxidative effect of hot water extract of the mushroom Ganoderma lucidum on ethanol-induced free radical generation, researchers at the Taipei Medical University Hospital showed that injection of the extract on dose-dependently exhibited antioxidative effect on mouse liver and kidney lipid peroxidation(9).
In the final report, Dr. Shieh YH, the lead scientist said, "The hepatic and renal protective mechanism of Ganoderma lucidum, might be due at least in part to its prominent superoxide scavenging effect. Ganoderma extract could protect the liver and kidney from superoxide-induced hepatic and renal damages".
The hot water extracts also were shown to have antioxidative effects against heart and chemical toxicity(12), according to the Mackay Memorial Hospital(10).
Furthermore, the mushroom polysaccharides protect skin fibroblasts against UVB-induced photoaging(11).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The protective effects of garlic extract against acetaminophen-induced oxidative stress and glutathione depletion by Anoush M1, Eghbal MA, Fathiazad F, Hamzeiy H, Kouzehkonani NS(PubMed)
(2) Protective effects of Centella asiatica leaf extract on dimethylnitrosamine‑induced liver injury in rats by Choi MJ1, Zheng HM1, Kim JM2, Lee KW3, Park YH3, Lee DH(PubMed)
(3) Effect of Centella asiatica on arsenic-induced oxidative stress and metal distribution in rats by Gupta R1, Flora SJ(PubMed)
(4) Protective effect of extract from Paeonia lactiflora and Astragalus membranaceous against liver injury induced by bacillus Calmette-Guérin and lipopolysaccharide in mice by Sun WY1, Wei W, Gui SY, Wu L, Wang H(PubMed)
(5) [Protective effect of astragalus saponin extracts on kidneys of diabetic rats].[Article in Chinese] by Xiao F, Hu YG, Wu SN, Shou QY, Cai YQ, Wang HM, Wang H(PubMed)
(6) Protective effect of Schisandra chinensis bee pollen extract on liver and kidney injury induced by cisplatin in rats by Huang H1, Shen Z1, Geng Q2, Wu Z2, Shi P3, Miao X(PubMed)
(7) Protective Effect of Polyphenol-Rich Extract from Bee Pollen in a High-Fat Diet by Rzepecka-Stojko A1, Kabała-Dzik A2, Kubina R3, Jasik K4, Kajor M5, Wrześniok D6, Stojko J(PubMed)
(8) Protective effect of dihydromyricetin on LPS-induced acute lung injury by Wang B1, Xiao Y1, Yang X1, He Y1, Jing T1, Wang W2, Zhang J3, Lin R(PubMed)
(9) Evaluation of the hepatic and renal-protective effects of Ganoderma lucidum in mice by Shieh YH1, Liu CF, Huang YK, Yang JY, Wu IL, Lin CH, Li SC(PubMed)
(10) Antioxidant activity of Ganoderma lucidum in acute ethanol-induced heart toxicity by Wong KL1, Chao HH, Chan P, Chang LP, Liu CF(PubMed)
(11) Antioxidant activity of Ganoderma lucidum in acute ethanol-induced heart toxicity by Wong KL1, Chao HH, Chan P, Chang LP, Liu CF. (PubMed)
(12) Protective effect of vanilloids against chemical stress on the white-rot fungus Ganoderma lucidum by Kuhar F1, Papinutti L(PubMed)
(13) Effects of some thiol chelators on enzymatic activities in blood, liver, and kidneys of acute arsenic (III) exposed mice by Tripathi N1, Flora SJ(PubMed)
The Western diet contains high saturated fat, trans fat, and other harmful substances such as sugar, caffeine, pesticides, and addictive substances, and less in fruits and vegetables.
These types of harmful substances are toxic.
Detoxification is a natural process of our body to maintain the proper function and protect our organs and tissues against toxicity by eliminating toxins accumulated.
When they fail, the toxic accumulations cause a disruption of hormone production, damage the body's detoxification organs and weaken the immune system, leading to hormone imbalance and many chronic illnesses consequently.
Some researchers suggested that overexpression of toxins may lead to an imbalance of the ratio of free radicals and antioxidants produced by the antioxidant enzymes of tissue, leading to oxidative stress in the induction of cytotoxicity.
Cytotoxicity not only damages healthy cells but also alternates cell DNA transcription, one of the major causes of cancer.
The natural remedies detox and nourish your Immune system, Brain, Liver, Kidney, Skin, Lungs, and Blood include
1. Garlic extract
Garlic extract is a widely used medication in the world with a proven record in preventing and treating heart disease, increasing circulation of blood flow, and protecting our kidneys and liver against injury and damage caused by ROS-inducing cytotoxicity.
According to a 2009 study by Tabriz University of Medical Sciences, the application of garlic extract in tested mice reserved liver toxicity caused by overdosing on acetaminophen in the induction of oxidative stress and depletion of the host antioxidants, such as glutathione (GSH)(1).
Dr. Anoush M, the lead scientist said, "Acetaminophen, the most commonly sold over-the-counter antipyretic analgesic, is capable of causing severe and sometimes fatal hepatic damage in humans and experimental animals".
The herb also strengthens our system's fight against the degeneration of our body.
2. Gotu Kola
Gotu Kola is also known as cetenlla asiatica with a strong effect in treating nervous system disorders caused by inflammation and improving alertness and memory.
According to the Inha University Hospital, the application of leaf extract exerted a significant activity in reduced oxidative stress induced by injection of dimethylnitrosamine‑induced liver injury in rats(2).
The results of these actions were attributed to the extract significantly decreasing the level of malondialdehyde and increasing the levels of host antioxidant enzymes, including superoxide dismutase, glutathione peroxidase, and catalase, and may have provided protection against the deleterious effects of reactive oxygen species.
In metal toxins accumulation by arsenic exposure (20 ppm in drinking water for 4 weeks) injection in tested rats, application of oral supplementation of Centella Asiatica (100, 200 or 300 mg kg(-1), orally once daily displayed a strong inhibition of delta-aminolevulinic acid dehydratase (ALAD) activity in induction of increased oxidized glutathione (GSSG) and thiobarbituric acid reactive substance (TBARS) levels(3).
Overexpression of ROS can lead to liver, kidney, and brain damage permanently(3).
These results suggested that Gotu Kola antitoxins in the liver, kidney, and blood effect(13) may be considered as a co-administration during chelation therapy with a thiol chelator(3).
With enormous antioxidant properties, Gotu kola can also rejuvenate the body against the forming of free radicals in induced early aging.
3. Astragalus
Astragalus is used in traditional Chinese medicine for strengthening our body in fighting against diseases and protecting cells from free radicals through its antioxidant activity.
Herbal medicine also is an excellent agent in the fight against virus and bacteria and restore our body's energy.
According to the Institute of Clinical Pharmacology, Anhui Medical University, extract isolated from the roots of P. lactifloruala and A. membranaceus demonstrated better hepatoprotective activity in compared to the application of individual herbs used separately(4), through antioxidant activity.
Furthermore, injection in animal models suggested that astragalus saponin extracts (AS) process strong kidneys protective in diabetic rats(5). through the reduction of renal pathological changes.
4. Bee Pollen
Bee pollen is said to contain all the essential components of life.
According to traditional herbal medicine, the herb process unified activity by correcting the deficiency, rebalancing nutrition, and improving our immune system as well as rejuvenating our body.
In concerns of Cisplatin (CP), after application to patients with an aim to cure cancers although it is effective in clinics, however, it could induce toxic effects, researchers at the Fujian Agriculture and Forestry University, conducted an experiment to test whether bee pollen, a natural compound, produced by honey bees has a potential inhibited expression of these toxic effects(6).
The results are so astonishing, the application of bee pollen extract (SCBPE) reversed the damage to the liver and kidney caused by Cisplatin (CP) by improving the antioxidant, anti-inflammatory, and anti-apoptotic capacity of the body.
Moreover, antioxidant-rich bee pollen also demonstrated a strong preventive effect against histological changes in the liver and cardiac blood vessels, abnormalities of lipid profile, and the levels of oxidized low-density lipoproteins (ox-LDL), asymmetric dimethylarginine (ADMA), angiotensin-converting enzyme (ACE), and angiotensin II (ANG II) caused by a high-fat diet in C57BL₆ mice(7).
5. Dock
The dock contains vitamin C and vitamin A.
The herbal medicine not only promotes a strong immune system but also dissolves heavy metal accumulated in our body and prevents muscular degeneration.
According to the Xi'an Jiaotong University Health Science Center, dihydromyricetin (DHM), a bioactive flavonoid component isolated from dock against lung injury and damage caused by injection of LPS(8).
6. Reishi Mushroom
Reishi Mushroom contains ganoderic acids with function in strengthening our immune system's fight against inflammation.
In the study to evaluate the antioxidative effect of hot water extract of the mushroom Ganoderma lucidum on ethanol-induced free radical generation, researchers at the Taipei Medical University Hospital showed that injection of the extract on dose-dependently exhibited antioxidative effect on mouse liver and kidney lipid peroxidation(9).
In the final report, Dr. Shieh YH, the lead scientist said, "The hepatic and renal protective mechanism of Ganoderma lucidum, might be due at least in part to its prominent superoxide scavenging effect. Ganoderma extract could protect the liver and kidney from superoxide-induced hepatic and renal damages".
The hot water extracts also were shown to have antioxidative effects against heart and chemical toxicity(12), according to the Mackay Memorial Hospital(10).
Furthermore, the mushroom polysaccharides protect skin fibroblasts against UVB-induced photoaging(11).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The protective effects of garlic extract against acetaminophen-induced oxidative stress and glutathione depletion by Anoush M1, Eghbal MA, Fathiazad F, Hamzeiy H, Kouzehkonani NS(PubMed)
(2) Protective effects of Centella asiatica leaf extract on dimethylnitrosamine‑induced liver injury in rats by Choi MJ1, Zheng HM1, Kim JM2, Lee KW3, Park YH3, Lee DH(PubMed)
(3) Effect of Centella asiatica on arsenic-induced oxidative stress and metal distribution in rats by Gupta R1, Flora SJ(PubMed)
(4) Protective effect of extract from Paeonia lactiflora and Astragalus membranaceous against liver injury induced by bacillus Calmette-Guérin and lipopolysaccharide in mice by Sun WY1, Wei W, Gui SY, Wu L, Wang H(PubMed)
(5) [Protective effect of astragalus saponin extracts on kidneys of diabetic rats].[Article in Chinese] by Xiao F, Hu YG, Wu SN, Shou QY, Cai YQ, Wang HM, Wang H(PubMed)
(6) Protective effect of Schisandra chinensis bee pollen extract on liver and kidney injury induced by cisplatin in rats by Huang H1, Shen Z1, Geng Q2, Wu Z2, Shi P3, Miao X(PubMed)
(7) Protective Effect of Polyphenol-Rich Extract from Bee Pollen in a High-Fat Diet by Rzepecka-Stojko A1, Kabała-Dzik A2, Kubina R3, Jasik K4, Kajor M5, Wrześniok D6, Stojko J(PubMed)
(8) Protective effect of dihydromyricetin on LPS-induced acute lung injury by Wang B1, Xiao Y1, Yang X1, He Y1, Jing T1, Wang W2, Zhang J3, Lin R(PubMed)
(9) Evaluation of the hepatic and renal-protective effects of Ganoderma lucidum in mice by Shieh YH1, Liu CF, Huang YK, Yang JY, Wu IL, Lin CH, Li SC(PubMed)
(10) Antioxidant activity of Ganoderma lucidum in acute ethanol-induced heart toxicity by Wong KL1, Chao HH, Chan P, Chang LP, Liu CF(PubMed)
(11) Antioxidant activity of Ganoderma lucidum in acute ethanol-induced heart toxicity by Wong KL1, Chao HH, Chan P, Chang LP, Liu CF. (PubMed)
(12) Protective effect of vanilloids against chemical stress on the white-rot fungus Ganoderma lucidum by Kuhar F1, Papinutti L(PubMed)
(13) Effects of some thiol chelators on enzymatic activities in blood, liver, and kidneys of acute arsenic (III) exposed mice by Tripathi N1, Flora SJ(PubMed)
The Anti #OverGrowth of #CandidaAlbicans #NaturalRemedies, According to Studies
Kyle J. Norton
Candida albicans are members of a large group of microorganism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.
Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).
According to a joint study, in many cases, biofilm(microorganisms with cells sticking to each other on a surface) formation(7) gene mutations(8), and overexpression of genes(9)(10) are often associated with increased candida resistance toward antifungal drugs.
Herbal medicine or phytotherapy is a traditional practice that used botany and plants for the treatment of a variety of diseases.
Today, due to serious side effects caused by the intake of conventional single-ingredient medication, some scientists once again have looked into herbal whole-food plants with the aim to find replacements with similar effects without inducing adverse effects.
These journeys have encountered many problems, as the discovery of such plants will provide no commercial benefit and patent right to producers. Particularly, if such plants are found, they will exert a major blow in cutting into sizable benefits of big pharmaceutical companies
Truly, between 25 to 50% of current pharmaceuticals are derived from plants, and none are used as antimicrobials(b).
Some researchers suggested that duplicated herbal successes of Western drugs with the synthetic version for the patent right without using the whole herb ingredients for commercial profits may eventually contribute to the overexpression of serious adverse effects(b).
The imbalance of the ratio of ROS species and antioxidant enzymes in the host tissue has played an essential role in the initiated expression of healthy cell cytotoxicity that can alternate DNA transcription in facilitating the development of chronic ailments such as the overgrowth of candida.
In free radical expression caused by growth candida, certain natural alternatives exerted a strong antioxidant effect that targets Candida.
According to Dr. Seneviratne CJ at the University of Hong Kong, in the study of "Potent anti-traditional Chinese herbal plant contains significant and potent antifungal activities, such as Rhizoma Coptidis and Cortex phellodendri Chinesis on three different non-albicans Candida species, C. glabrata, C. krusei and C. tropicalis(a).
The Anti Over Growth of Candida Natural Alternatives
1. Manuka Honey
Manuka honey has been known to benefit humans in healing wounds and injuries(309) without inducing damage to cells. The product also contains hydrogen peroxide claimed to have antimicrobial properties (310), including Candida albicans(311).
2. Undecylenic acid
Undecylenic acid is the common name of the 10-undecenoic acid, an organic unsaturated fatty acid derived from castor oil, It is a natural antimicrobial property(312)against fungal skin infections(313)(314) and Candida albicans(315).
3. Caprylic acid
Caprylic acid is the common name for the eight-carbon saturated fatty acid found naturally in coconuts and breast milk, used in treatments for a variety of conditions, including Candida(316)(317).
4. Echinacea angustifolia
Echinacea angustifolia is a herbaceous plant species Echinacea angustifolia, belongings to the family Asteraceae native to Northern America. Echinacea angustifolia besides enhances the immune system function(318)(319) against the invasion of bacteria and viral through its antioxidant effects, it also used to treat bacterial infections(320) and candida(318) in herb medicine.
5. Horopeit
Horopeit is a genus Pseudowintera, part of family Winteraceae. The herb contains a compound polygonal, a chemical compound used to suppress the growth of candida(321)(322) by damaging the permeable cell membrane of yeast(322).
6. Oregano
Oregano is a genus of the mint family Lamiaceae, native to southwestern Eurasia and the Mediterranean region. The herb not only promotes digestive health(323), clear skin and healthy immune system(324) but also dehydrates candida(325) by reacting with the water in the bloodstream, through its phytochemicals Carvacrol and Thymol(326).
7. Aloe vera
Aloe vera is a genus Aloe belongings to the family Asphodelaceae, which originated in Sudan. Besides containing significant amounts of amino acids, enzymes, vitamins, minerals and antioxidants which help to enhance the immune function(327) in fighting against virus and bacterial infection and inflammation(328), it also maintains a proper PH levels that inhibit the growth of candida(329) and repairs and seals the intestinal wall, which stops Candida from actually penetrating through and into your bloodstream(330).
8. Tea tree oil
Tea tree oil is a pale yellow color to nearly clear essential oil extracted from the leaves of the Narrow-leaved Tea-tree, native to the northeast coast of New South Wales, Australia. In Fluconazole-resistant candida Albicans strains, dose-depend manner, tea tree oil strongly exhibited fluconazole activity against fluconazole-resistant C. albicans strains, through its antifungal activity(331).
Terpinen-4-ol, the main bioactive component found in tea tree oil, also showed to accelerate clearance of all Candida strains from the vagina, including the azole-resistant forms in rat vaginal infection model(332)
9. Tannate plant extracts
Tannate is the salt or ester of tannic acid. Tannate plant extract is a powerful antifungal agent(333)(334) by destroying candida selectively without harming the good flora in the body(335). It is said that tannate plant extract is effective in treating bacteria, viruses, and fungal infections due to its antifungal(333)(334), and anti-inflammatory properties(336).
10. Biotin
Biotin or vitamin B7, a coenzyme in the metabolism of fatty acids and leucine, plays an important role in gluconeogenesis(337). According to Università degli Studi di Torino, patients with biotin deficiency are at high risk of candida albicans overgrowth(338).
Biotin prevents yeast to change into its fungal form(339), thus reducing the risk of candida albicans overgrowth.
11. Probiotics (friendly bacteria)
Probiotic is live microorganisms which benefit the host. Intake of probiotics enhances the production of hydrogen peroxide(340) which plays an important role in preventing candida overgrowth and through self-multiple mechanisms(341).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(a) Potent anti-microbial activity of traditional Chinese medicine herbs against Candida species by Seneviratne CJ1, Wong RW, Samaranayake LP. (PubMed)
(b) Plant Products as Antimicrobial Agents by Marjorie Murphy Cowan(PMC)(1) Non-albicans Candida spp. causing fungemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ. (PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeast species. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)(247) The role of vitamin E in T-cell differentiation and the decrease of cellular immunity with aging. by Moriguchi S1.(PubMed)
(310) Effect of hydrogen peroxide on antibacterial activities of Canadian honey by Brudzynski K1.(PubMed)
(311) Streptomyces sp. JS520 produces exceptionally high quantities of undecylprodigiosin with antibacterial, antioxidative, and UV-protective properties by Stankovic N1, Radulovic V, Petkovic M, Vuckovic I, Jadranin M, Vasiljevic B, Nikodinovic-Runic J.(PubMed)
(312) Antimicrobial polyurethane thermosets based on undecylenic acid: synthesis and evaluation.by Lluch C1, Esteve-Zarzoso B, Bordons A, Lligadas G, Ronda JC, Galià M, Cádiz V.(PubMed)
(313) Allergic contact dermatitis from undecylenic acid in a commercial antifungal nail solution by Anguita JL1, Escutia B, Marí JI, Rodríguez M, De La Cuadra J, Aliaga A.(PubMed)
(314) Undecylenic acid and fungous infections by Landau JW. (PubMed)
(315) Undecylenic acid inhibits morphogenesis of Candida albicans by McLain N1, Ascanio R, Baker C, Strohaver RA, Dolan JW.(PubMed)
(316) [Inhibition of Candida mycelia growth by a medium chain fatty acids, capric acid in vitro and its therapeutic efficacy in murine oral candidiasis].[Article in Japanese]by Takahashi M1, Inoue S, Hayama K, Ninomiya K, Abe S.(PubMed)
(317) [Effects of inhibitory activity on mycelial growth of Candida albicans and therapy for murine oral candidiasis by the combined use of terpinene-4-ol and a middle-chain fatty acid, capric acid].[Article in Japanese]by Ninomiya K1, Hayama K, Ishijima S, Takahashi M, Kurihara J, Abe S.(PubMed)
(318) In vitro and in vivo immune stimulating effects of a new standardized Echinacea angustifolia root extract (Polinacea) by Morazzoni P1, Cristoni A, Di Pierro F, Avanzini C, Ravarino D, Stornello S, Zucca M, Musso T.(PubMed)
(319) Immune enhancing effects of Echinacea purpurea root extract by reducing regulatory T cell number and function by Kim HR, Oh SK, Lim W, Lee HK, Moon BI, Seoh JY.(PubMed)
(320) Applications of the phytomedicine Echinacea purpurea (Purple Coneflower) in infectious diseases. by Hudson JB1.(PubMed)
(321) Anethole, a potential antimicrobial synergist, converts a fungistatic dodecanol to a fungicidal agentby Fujita K1, Fujita T, Kubo I.(PubMed)
(322) Polygodial, an antifungal potentiator by Kubo I1, Taniguchi M.(PubMed)
(323) Enterococci from piglets--probiotic properties and responsiveness to natural antibacterial substances by Strompfová V1, Lauková A.(PubMed)
(324) Dietary supplementation with two Lamiaceae herbs-(oregano and sage) modulates innate immunity parameters in Lumbricus terrestris by Vattem DA1, Lester C, Deleon R, Jamison B, Maitin V.(PubMed)
(325) Oregano Oil for Candida(New health guide)(326) In vitro activity of origanum vulgare essential oil against candidaspecies by Cleff MB1, Meinerz AR, Xavier M, Schuch LF, Schuch LF, Araújo Meireles MC, Alves Rodrigues MR, de Mello JR. (PubMed)
(327) Augmented humoral immune response and decreased cell-mediated immunity by Aloe vera in rats. by Halder S1, Mehta AK, Mediratta PK.(PubMed)
(328) Antimicrobial activity of preparation Bioaron C by Gawron-Gzella A, Michalak A, Kędzia A.(PubMed)
(329) Antimicrobial activity of plant extracts on Candida albicans: an in vitro study by Doddanna SJ1, Patel S, Sundarrao MA, Veerabhadrappa RS. (PubMed)
(330) Antifungals: Aloe Vera(The candida diets)
(331) The Influence of Tea Tree Oil (Melaleuca alternifolia) on Fluconazole Activity against Fluconazole-Resistant Candida albicans Strains by Mertas A1, Garbusińska A1, Szliszka E1, Jureczko A1, Kowalska M1, Król W1.(PubMed)
(332) In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species by Mondello F1, De Bernardis F, Girolamo A, Cassone A, Salvatore G.(PubMed)
(333) [The effect of tannic acid on the colonization of Candida in tissue conditioning material].
[Article in Japanese]by Kubota K.(PubMed)(334) [The effect of tannic acid on attachment of Candida albicans to plate denture lining material].
[Article in Japanese]by Tanaka T.(PubMed)
(335) Who Gets Yeast Infections? (Things for ladies)(336) Evaluation of Phytochemical Screening and Anti Inflammatory Activity of Leaves and Stem of Mikania scandens (L.) Wild by Banerjee S1, Chanda A1, Adhikari A2, Das A2, Biswas S3.(PubMed)
(337) The effect of oxalate on gluconeogenesis by isolated chicken hepatocytes. Increased sensitivity to inhibition as a result of biotin deficiency by Bannister DW, O'Neill IE. (PubMed)
(338) Growth of Candida albicans in a minimal synthetic medium without biotin. by Vidotto V1, Pugliese A, Gioannini P.(PubMed)
(339) Candida Infestation and BiotinWritten by Sean Brookwood Published on September 22, 2013
(340) Improved growth and viability of lactobacilli in the presence of Bacillus subtilis (natto), catalase, or subtilisin by Hosoi T1, Ametani A, Kiuchi K, Kaminogawa S.(PubMed)
(Oxidative stress responses in the human fungal pathogen, Candidaalbicans by Dantas Ada S1, Day A2, Ikeh M3, Kos I4, Achan B5, Quinn J6.(PubMed)
(341) Candida Diets: Part II: Hydrogen Peroxide Written by Jeff McCombs(342) Glutamine supplementation for young infants with severe gastrointestinal disease. by Brown JV1, Moe-Byrne T, McGuire W.(PubMed)
Candida albicans are members of a large group of microorganism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.
Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).
According to a joint study, in many cases, biofilm(microorganisms with cells sticking to each other on a surface) formation(7) gene mutations(8), and overexpression of genes(9)(10) are often associated with increased candida resistance toward antifungal drugs.
Herbal medicine or phytotherapy is a traditional practice that used botany and plants for the treatment of a variety of diseases.
Today, due to serious side effects caused by the intake of conventional single-ingredient medication, some scientists once again have looked into herbal whole-food plants with the aim to find replacements with similar effects without inducing adverse effects.
These journeys have encountered many problems, as the discovery of such plants will provide no commercial benefit and patent right to producers. Particularly, if such plants are found, they will exert a major blow in cutting into sizable benefits of big pharmaceutical companies
Truly, between 25 to 50% of current pharmaceuticals are derived from plants, and none are used as antimicrobials(b).
Some researchers suggested that duplicated herbal successes of Western drugs with the synthetic version for the patent right without using the whole herb ingredients for commercial profits may eventually contribute to the overexpression of serious adverse effects(b).
The imbalance of the ratio of ROS species and antioxidant enzymes in the host tissue has played an essential role in the initiated expression of healthy cell cytotoxicity that can alternate DNA transcription in facilitating the development of chronic ailments such as the overgrowth of candida.
In free radical expression caused by growth candida, certain natural alternatives exerted a strong antioxidant effect that targets Candida.
According to Dr. Seneviratne CJ at the University of Hong Kong, in the study of "Potent anti-traditional Chinese herbal plant contains significant and potent antifungal activities, such as Rhizoma Coptidis and Cortex phellodendri Chinesis on three different non-albicans Candida species, C. glabrata, C. krusei and C. tropicalis(a).
The Anti Over Growth of Candida Natural Alternatives
1. Manuka Honey
Manuka honey has been known to benefit humans in healing wounds and injuries(309) without inducing damage to cells. The product also contains hydrogen peroxide claimed to have antimicrobial properties (310), including Candida albicans(311).
2. Undecylenic acid
Undecylenic acid is the common name of the 10-undecenoic acid, an organic unsaturated fatty acid derived from castor oil, It is a natural antimicrobial property(312)against fungal skin infections(313)(314) and Candida albicans(315).
3. Caprylic acid
Caprylic acid is the common name for the eight-carbon saturated fatty acid found naturally in coconuts and breast milk, used in treatments for a variety of conditions, including Candida(316)(317).
4. Echinacea angustifolia
Echinacea angustifolia is a herbaceous plant species Echinacea angustifolia, belongings to the family Asteraceae native to Northern America. Echinacea angustifolia besides enhances the immune system function(318)(319) against the invasion of bacteria and viral through its antioxidant effects, it also used to treat bacterial infections(320) and candida(318) in herb medicine.
5. Horopeit
Horopeit is a genus Pseudowintera, part of family Winteraceae. The herb contains a compound polygonal, a chemical compound used to suppress the growth of candida(321)(322) by damaging the permeable cell membrane of yeast(322).
6. Oregano
Oregano is a genus of the mint family Lamiaceae, native to southwestern Eurasia and the Mediterranean region. The herb not only promotes digestive health(323), clear skin and healthy immune system(324) but also dehydrates candida(325) by reacting with the water in the bloodstream, through its phytochemicals Carvacrol and Thymol(326).
7. Aloe vera
Aloe vera is a genus Aloe belongings to the family Asphodelaceae, which originated in Sudan. Besides containing significant amounts of amino acids, enzymes, vitamins, minerals and antioxidants which help to enhance the immune function(327) in fighting against virus and bacterial infection and inflammation(328), it also maintains a proper PH levels that inhibit the growth of candida(329) and repairs and seals the intestinal wall, which stops Candida from actually penetrating through and into your bloodstream(330).
8. Tea tree oil
Tea tree oil is a pale yellow color to nearly clear essential oil extracted from the leaves of the Narrow-leaved Tea-tree, native to the northeast coast of New South Wales, Australia. In Fluconazole-resistant candida Albicans strains, dose-depend manner, tea tree oil strongly exhibited fluconazole activity against fluconazole-resistant C. albicans strains, through its antifungal activity(331).
Terpinen-4-ol, the main bioactive component found in tea tree oil, also showed to accelerate clearance of all Candida strains from the vagina, including the azole-resistant forms in rat vaginal infection model(332)
9. Tannate plant extracts
Tannate is the salt or ester of tannic acid. Tannate plant extract is a powerful antifungal agent(333)(334) by destroying candida selectively without harming the good flora in the body(335). It is said that tannate plant extract is effective in treating bacteria, viruses, and fungal infections due to its antifungal(333)(334), and anti-inflammatory properties(336).
10. Biotin
Biotin or vitamin B7, a coenzyme in the metabolism of fatty acids and leucine, plays an important role in gluconeogenesis(337). According to Università degli Studi di Torino, patients with biotin deficiency are at high risk of candida albicans overgrowth(338).
Biotin prevents yeast to change into its fungal form(339), thus reducing the risk of candida albicans overgrowth.
11. Probiotics (friendly bacteria)
Probiotic is live microorganisms which benefit the host. Intake of probiotics enhances the production of hydrogen peroxide(340) which plays an important role in preventing candida overgrowth and through self-multiple mechanisms(341).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(a) Potent anti-microbial activity of traditional Chinese medicine herbs against Candida species by Seneviratne CJ1, Wong RW, Samaranayake LP. (PubMed)
(b) Plant Products as Antimicrobial Agents by Marjorie Murphy Cowan(PMC)(1) Non-albicans Candida spp. causing fungemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ. (PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeast species. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)(247) The role of vitamin E in T-cell differentiation and the decrease of cellular immunity with aging. by Moriguchi S1.(PubMed)
(310) Effect of hydrogen peroxide on antibacterial activities of Canadian honey by Brudzynski K1.(PubMed)
(311) Streptomyces sp. JS520 produces exceptionally high quantities of undecylprodigiosin with antibacterial, antioxidative, and UV-protective properties by Stankovic N1, Radulovic V, Petkovic M, Vuckovic I, Jadranin M, Vasiljevic B, Nikodinovic-Runic J.(PubMed)
(312) Antimicrobial polyurethane thermosets based on undecylenic acid: synthesis and evaluation.by Lluch C1, Esteve-Zarzoso B, Bordons A, Lligadas G, Ronda JC, Galià M, Cádiz V.(PubMed)
(313) Allergic contact dermatitis from undecylenic acid in a commercial antifungal nail solution by Anguita JL1, Escutia B, Marí JI, Rodríguez M, De La Cuadra J, Aliaga A.(PubMed)
(314) Undecylenic acid and fungous infections by Landau JW. (PubMed)
(315) Undecylenic acid inhibits morphogenesis of Candida albicans by McLain N1, Ascanio R, Baker C, Strohaver RA, Dolan JW.(PubMed)
(316) [Inhibition of Candida mycelia growth by a medium chain fatty acids, capric acid in vitro and its therapeutic efficacy in murine oral candidiasis].[Article in Japanese]by Takahashi M1, Inoue S, Hayama K, Ninomiya K, Abe S.(PubMed)
(317) [Effects of inhibitory activity on mycelial growth of Candida albicans and therapy for murine oral candidiasis by the combined use of terpinene-4-ol and a middle-chain fatty acid, capric acid].[Article in Japanese]by Ninomiya K1, Hayama K, Ishijima S, Takahashi M, Kurihara J, Abe S.(PubMed)
(318) In vitro and in vivo immune stimulating effects of a new standardized Echinacea angustifolia root extract (Polinacea) by Morazzoni P1, Cristoni A, Di Pierro F, Avanzini C, Ravarino D, Stornello S, Zucca M, Musso T.(PubMed)
(319) Immune enhancing effects of Echinacea purpurea root extract by reducing regulatory T cell number and function by Kim HR, Oh SK, Lim W, Lee HK, Moon BI, Seoh JY.(PubMed)
(320) Applications of the phytomedicine Echinacea purpurea (Purple Coneflower) in infectious diseases. by Hudson JB1.(PubMed)
(321) Anethole, a potential antimicrobial synergist, converts a fungistatic dodecanol to a fungicidal agentby Fujita K1, Fujita T, Kubo I.(PubMed)
(322) Polygodial, an antifungal potentiator by Kubo I1, Taniguchi M.(PubMed)
(323) Enterococci from piglets--probiotic properties and responsiveness to natural antibacterial substances by Strompfová V1, Lauková A.(PubMed)
(324) Dietary supplementation with two Lamiaceae herbs-(oregano and sage) modulates innate immunity parameters in Lumbricus terrestris by Vattem DA1, Lester C, Deleon R, Jamison B, Maitin V.(PubMed)
(325) Oregano Oil for Candida(New health guide)(326) In vitro activity of origanum vulgare essential oil against candidaspecies by Cleff MB1, Meinerz AR, Xavier M, Schuch LF, Schuch LF, Araújo Meireles MC, Alves Rodrigues MR, de Mello JR. (PubMed)
(327) Augmented humoral immune response and decreased cell-mediated immunity by Aloe vera in rats. by Halder S1, Mehta AK, Mediratta PK.(PubMed)
(328) Antimicrobial activity of preparation Bioaron C by Gawron-Gzella A, Michalak A, Kędzia A.(PubMed)
(329) Antimicrobial activity of plant extracts on Candida albicans: an in vitro study by Doddanna SJ1, Patel S, Sundarrao MA, Veerabhadrappa RS. (PubMed)
(330) Antifungals: Aloe Vera(The candida diets)
(331) The Influence of Tea Tree Oil (Melaleuca alternifolia) on Fluconazole Activity against Fluconazole-Resistant Candida albicans Strains by Mertas A1, Garbusińska A1, Szliszka E1, Jureczko A1, Kowalska M1, Król W1.(PubMed)
(332) In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species by Mondello F1, De Bernardis F, Girolamo A, Cassone A, Salvatore G.(PubMed)
(333) [The effect of tannic acid on the colonization of Candida in tissue conditioning material].
[Article in Japanese]by Kubota K.(PubMed)(334) [The effect of tannic acid on attachment of Candida albicans to plate denture lining material].
[Article in Japanese]by Tanaka T.(PubMed)
(335) Who Gets Yeast Infections? (Things for ladies)(336) Evaluation of Phytochemical Screening and Anti Inflammatory Activity of Leaves and Stem of Mikania scandens (L.) Wild by Banerjee S1, Chanda A1, Adhikari A2, Das A2, Biswas S3.(PubMed)
(337) The effect of oxalate on gluconeogenesis by isolated chicken hepatocytes. Increased sensitivity to inhibition as a result of biotin deficiency by Bannister DW, O'Neill IE. (PubMed)
(338) Growth of Candida albicans in a minimal synthetic medium without biotin. by Vidotto V1, Pugliese A, Gioannini P.(PubMed)
(339) Candida Infestation and BiotinWritten by Sean Brookwood Published on September 22, 2013
(340) Improved growth and viability of lactobacilli in the presence of Bacillus subtilis (natto), catalase, or subtilisin by Hosoi T1, Ametani A, Kiuchi K, Kaminogawa S.(PubMed)
(Oxidative stress responses in the human fungal pathogen, Candidaalbicans by Dantas Ada S1, Day A2, Ikeh M3, Kos I4, Achan B5, Quinn J6.(PubMed)
(341) Candida Diets: Part II: Hydrogen Peroxide Written by Jeff McCombs(342) Glutamine supplementation for young infants with severe gastrointestinal disease. by Brown JV1, Moe-Byrne T, McGuire W.(PubMed)
#Greentea #EGCG Inhibits the Risk of #BreastCancer by Inactivating Signaling Pathway and Modifying Estrogenic Activity Against Cell Proliferation, Researchers Show
Kyle J. Norton
Green tea may be the next generation of inexpensive herbal medicine for reduced risk and treatment of breast cancer, a renowned institute study suggested.
Breast cancer (malignant breast neoplasm) is cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there are also rare cases that breast cancer starts in other areas of the breast.
Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "excessive yin syndrome" or "yang vacuity syndrome" including weakened immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
According to a joint study led by the Xinyang Normal UniversityHenan, Epigallocatechin-3-gallate (EGCG), a bioactive compound in green tea inhibited the risk of breast cancer through many mechanisms involving primarily cell death and survival.
The study also insisted the efficacy of Epigallocatechin-3-gallate (EGCG) in reducing the risk of breast cancer is probably due to the main function in induced cancer cell cycle arrest in interference of cell division.
In the MDA-MB-231 breast cancer cell line, Epigallocatechin gallate isolated from green tea induced apoptosis and inhibited tumorigenesis through the expression of multiple signaling pathways in breast cancer cells.
Also, EGCG decreased MDA-MB-231 cell viability and significantly downregulated the expression of β-catenin in regulating the coordination of cell–cell adhesion and gene transcription, according to Western blot analysis as patients with breast cancer are found to associate with high levels of β-catenin in breast cancer tissue than in normal tissue.
Dr. Hong OY, the lead author said, "EGCG inhibits the growth of MDA-MB-231 cells through the inactivation of the β-catenin signaling pathway. Based on these promising results, EGCG may be a potential treatment for triple-negative breast cancer patients.".
In polychlorinated biphenyls (PCBs) accumulated in human breast cancer tissue induced the growth of estrogen-sensitive tumors, EGCG inhibited the early onset of breast cancer by modifying estrogenic activity against cell proliferation in a dose-dependent manner.
Furthermore, at the dose of 25 μM, EGCG also exerted antiproliferative and pro-apoptotic action in the activation of the ERβ receptor.
The information collected above, green tea, containing rich sources of anti-malignant and non-malignant tumors phytochemicals, may be considered as a functional food in reduced risk and treatment of breast cancer.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Bioinformatic Prediction of Possible Targets and Mechanisms of Action of the Green TeaCompound Epigallocatechin-3-Gallate Against Breast Cancer by Song X1,2, Zhang M3, Chen L1, Lin Q2.(PubMed)
(2) Epigallocatechin gallate inhibits the growth of MDA-MB-231 breast cancer cells via inactivation of the β-catenin signaling pathway by Hong OY1, Noh EM2, Jang HY1, Lee YR2, Lee BK3, Jung SH3, Kim JS1, Youn HJ3. (PubMed)
(3) Green Tea Catechin, EGCG, Suppresses PCB 102-Induced Proliferation in Estrogen-Sensitive Breast Cancer Cells by Baker KM1, Bauer AC2.(PubMed)
Green tea may be the next generation of inexpensive herbal medicine for reduced risk and treatment of breast cancer, a renowned institute study suggested.
Breast cancer (malignant breast neoplasm) is cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there are also rare cases that breast cancer starts in other areas of the breast.
Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "excessive yin syndrome" or "yang vacuity syndrome" including weakened immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
According to a joint study led by the Xinyang Normal UniversityHenan, Epigallocatechin-3-gallate (EGCG), a bioactive compound in green tea inhibited the risk of breast cancer through many mechanisms involving primarily cell death and survival.
The study also insisted the efficacy of Epigallocatechin-3-gallate (EGCG) in reducing the risk of breast cancer is probably due to the main function in induced cancer cell cycle arrest in interference of cell division.
In the MDA-MB-231 breast cancer cell line, Epigallocatechin gallate isolated from green tea induced apoptosis and inhibited tumorigenesis through the expression of multiple signaling pathways in breast cancer cells.
Also, EGCG decreased MDA-MB-231 cell viability and significantly downregulated the expression of β-catenin in regulating the coordination of cell–cell adhesion and gene transcription, according to Western blot analysis as patients with breast cancer are found to associate with high levels of β-catenin in breast cancer tissue than in normal tissue.
Dr. Hong OY, the lead author said, "EGCG inhibits the growth of MDA-MB-231 cells through the inactivation of the β-catenin signaling pathway. Based on these promising results, EGCG may be a potential treatment for triple-negative breast cancer patients.".
In polychlorinated biphenyls (PCBs) accumulated in human breast cancer tissue induced the growth of estrogen-sensitive tumors, EGCG inhibited the early onset of breast cancer by modifying estrogenic activity against cell proliferation in a dose-dependent manner.
Furthermore, at the dose of 25 μM, EGCG also exerted antiproliferative and pro-apoptotic action in the activation of the ERβ receptor.
The information collected above, green tea, containing rich sources of anti-malignant and non-malignant tumors phytochemicals, may be considered as a functional food in reduced risk and treatment of breast cancer.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Bioinformatic Prediction of Possible Targets and Mechanisms of Action of the Green TeaCompound Epigallocatechin-3-Gallate Against Breast Cancer by Song X1,2, Zhang M3, Chen L1, Lin Q2.(PubMed)
(2) Epigallocatechin gallate inhibits the growth of MDA-MB-231 breast cancer cells via inactivation of the β-catenin signaling pathway by Hong OY1, Noh EM2, Jang HY1, Lee YR2, Lee BK3, Jung SH3, Kim JS1, Youn HJ3. (PubMed)
(3) Green Tea Catechin, EGCG, Suppresses PCB 102-Induced Proliferation in Estrogen-Sensitive Breast Cancer Cells by Baker KM1, Bauer AC2.(PubMed)
#GreenTea Promotes #OralHealth Through its Antioxiant and AntiBacterial Activities, Researchers Say
Kyle J. Norton
Green tea may have a potential effect in the promotion of oral health against bacterial-induced tooth decay or cavities, some institutes suggested.
Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "excessive yin syndrome" or "yang vacuity syndrome" including lack of energy, weaken immunity, and painful cases of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
According to the Technion-Israel Institute of Technology, Polyphenols including epigallocatechin 3 gallate (EGCG) isolated from green tea ameliorated oral cavity oxidative stress and inflammation, cigarette smoking and cigarettes' deleterious compounds nicotine and acrolein.
Dr. Narotzki B, the lead author of the study said, " Generally, green tea defends healthy cells from malignant transformation and locally has the ability to induce apoptosis in oral cancer cells. Altogether, there is an increasing interest in the health benefits of green tea in the field of oral health".
In the review of the beneficial effects of green tea on oral disease, researchers found that green tea not only reduced the bacterial activity in the oral cavity in an expression of the aforementioned oral afflictions but also attenuated the risk of oral cancer through antioxidant activities.
EGCG, in Solobacterium moorei, a volatile sulfide compound (VSC)-producing Gram-positive anaerobic bacterium study, displayed a significant effect in inhibiting the growth of S. moorei, with MIC values of 500 and 250 μg/ml resulting in reduced the adherence of S. moorei to oral epithelial cells.
The study also suggested the efficacy of green tea extract and EGCG protected oral health by inhibiting the progression of Solobacterium moorei probably through the ameliorated S. moorei's β-galactosidase activity in the production of volatile sulfide compound (VSC) in the doses dependent manner.
Green tea with abundant natural compounds may be the next generation of whole food used as therapeutic supplement in promoted oral healthcare.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Green tea: a promising natural product in oral health by Narotzki B1, Reznick AZ, Aizenbud D, Levy Y.(PubMed)
(2) Green Tea (Camellia Sinensis): Chemistry and Oral Health by Khurshid Z1, Zafar MS2, Zohaib S3, Najeeb S4, Naseem M5.(PubMed)
(3) Green tea extract and its major constituent epigallocatechin-3-gallate inhibit growth and halitosis-related properties of Solobacterium moorei by Morin MP1, Bedran TB2, Fournier-Larente J3, Haas B4, Azelmat J5, Grenier D6.(PubMed)
Green tea may have a potential effect in the promotion of oral health against bacterial-induced tooth decay or cavities, some institutes suggested.
Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "excessive yin syndrome" or "yang vacuity syndrome" including lack of energy, weaken immunity, and painful cases of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
According to the Technion-Israel Institute of Technology, Polyphenols including epigallocatechin 3 gallate (EGCG) isolated from green tea ameliorated oral cavity oxidative stress and inflammation, cigarette smoking and cigarettes' deleterious compounds nicotine and acrolein.
Dr. Narotzki B, the lead author of the study said, " Generally, green tea defends healthy cells from malignant transformation and locally has the ability to induce apoptosis in oral cancer cells. Altogether, there is an increasing interest in the health benefits of green tea in the field of oral health".
In the review of the beneficial effects of green tea on oral disease, researchers found that green tea not only reduced the bacterial activity in the oral cavity in an expression of the aforementioned oral afflictions but also attenuated the risk of oral cancer through antioxidant activities.
EGCG, in Solobacterium moorei, a volatile sulfide compound (VSC)-producing Gram-positive anaerobic bacterium study, displayed a significant effect in inhibiting the growth of S. moorei, with MIC values of 500 and 250 μg/ml resulting in reduced the adherence of S. moorei to oral epithelial cells.
The study also suggested the efficacy of green tea extract and EGCG protected oral health by inhibiting the progression of Solobacterium moorei probably through the ameliorated S. moorei's β-galactosidase activity in the production of volatile sulfide compound (VSC) in the doses dependent manner.
Green tea with abundant natural compounds may be the next generation of whole food used as therapeutic supplement in promoted oral healthcare.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Green tea: a promising natural product in oral health by Narotzki B1, Reznick AZ, Aizenbud D, Levy Y.(PubMed)
(2) Green Tea (Camellia Sinensis): Chemistry and Oral Health by Khurshid Z1, Zafar MS2, Zohaib S3, Najeeb S4, Naseem M5.(PubMed)
(3) Green tea extract and its major constituent epigallocatechin-3-gallate inhibit growth and halitosis-related properties of Solobacterium moorei by Morin MP1, Bedran TB2, Fournier-Larente J3, Haas B4, Azelmat J5, Grenier D6.(PubMed)
#Greentea Intake Daily Linearly Is Associated with A Reduced Risk of Depessive Symptoms of Depression, According to Studies
Kyle J. Norton
The use of plants for healing purposes has been predated long before the existence of modern medicine. Herbal plants have formed a fundamental source for conventional medicine in the discovery of single-ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......
Green tea is found to consist a psychological effect on patients with depression, a renowned institute study suggested
Depression is a normal response as part of our daily lives such as the loss of s job, the death of a loved one, and illness, affecting the way you eat, sleep, and the way you feel about yourself. Over 30 million Americans suffer from depression and the amount is increasing at an alarming rate.
Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "excessive yin syndrome" or "yang vacuity syndrome" including weakened immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
In a cross-sectional study of the consumption of green tea and coffee ascertained with a validated dietary questionnaire and the amount of caffeine intake estimated from these beverages, green tea consumption is associated to reduce symptoms of depression, depending on the amount of intake.
In comparison to the amount intake of participants, the study also found that participants who consumed ≥4 cups of green tea/d had a 51% significantly lower prevalence odds of having depressive symptoms than those who consumed less than 1 cup/d.
Dr. Pham NM, the lead author in the study said, "Higher consumption of green tea, coffee, and caffeine may confer protection against depression".
In vivo, green tea(GT) and GABA green tea (GGT) also expressed a protective activity against post-stroke depression (PSD), a common consequence of stroke, according to a joint study led by the Pavia University.
In a mouse model of post-stroke depression, GGT and GT enhance the activity in the modulation of depressive symptoms through decreased oxidative stress, and increased antioxidant endogenous defenses, including polyphenol, theanine, glutamine, etc......
Furthermore, in the review of Embase, PubMed, and Chinese National Knowledge Infrastructure databases from their inception through August 2014, tea consumption of more than 3 cups a day showed a significant decrease in the risk of depression of 37% (RR = 0.63, 95% CI: 0.55-0.71), in compared to individuals with lower tea consumption and those with higher tea consumption.
Taken together, there is no doubt, green tea may be used as a functional food in reduced symptoms and risk of depression if consumes daily. However, oral administration of large amounts daily should be taken with care, particularly for people with yin constituents.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Green tea and coffee consumption is inversely associated with depressive symptoms in a Japanese working population by Pham NM1, Nanri A1, Kurotani K1, Kuwahara K1, Kume A1, Sato M2, Hayabuchi H3, Mizoue T1. (PubMed)
(2) Antidepressive-like effects and antioxidant activity of green tea and GABA green tea in a mouse model of post-stroke depression by Di Lorenzo A1, Nabavi SF2, Sureda A3, Moghaddam AH4, Khanjani S4, Arcidiaco P5, Nabavi SM2, Daglia M1. (PubMed)
(3) Effect of green tea on reward learning in healthy individuals: a randomized, double-blind, placebo-controlled pilot study by Zhang Q1, Yang H, Wang J, Li A, Zhang W, Cui X, Wang K.(PubMed)
The use of plants for healing purposes has been predated long before the existence of modern medicine. Herbal plants have formed a fundamental source for conventional medicine in the discovery of single-ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......
Green tea is found to consist a psychological effect on patients with depression, a renowned institute study suggested
Depression is a normal response as part of our daily lives such as the loss of s job, the death of a loved one, and illness, affecting the way you eat, sleep, and the way you feel about yourself. Over 30 million Americans suffer from depression and the amount is increasing at an alarming rate.
Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "excessive yin syndrome" or "yang vacuity syndrome" including weakened immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
In a cross-sectional study of the consumption of green tea and coffee ascertained with a validated dietary questionnaire and the amount of caffeine intake estimated from these beverages, green tea consumption is associated to reduce symptoms of depression, depending on the amount of intake.
In comparison to the amount intake of participants, the study also found that participants who consumed ≥4 cups of green tea/d had a 51% significantly lower prevalence odds of having depressive symptoms than those who consumed less than 1 cup/d.
Dr. Pham NM, the lead author in the study said, "Higher consumption of green tea, coffee, and caffeine may confer protection against depression".
In vivo, green tea(GT) and GABA green tea (GGT) also expressed a protective activity against post-stroke depression (PSD), a common consequence of stroke, according to a joint study led by the Pavia University.
In a mouse model of post-stroke depression, GGT and GT enhance the activity in the modulation of depressive symptoms through decreased oxidative stress, and increased antioxidant endogenous defenses, including polyphenol, theanine, glutamine, etc......
Furthermore, in the review of Embase, PubMed, and Chinese National Knowledge Infrastructure databases from their inception through August 2014, tea consumption of more than 3 cups a day showed a significant decrease in the risk of depression of 37% (RR = 0.63, 95% CI: 0.55-0.71), in compared to individuals with lower tea consumption and those with higher tea consumption.
Taken together, there is no doubt, green tea may be used as a functional food in reduced symptoms and risk of depression if consumes daily. However, oral administration of large amounts daily should be taken with care, particularly for people with yin constituents.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Green tea and coffee consumption is inversely associated with depressive symptoms in a Japanese working population by Pham NM1, Nanri A1, Kurotani K1, Kuwahara K1, Kume A1, Sato M2, Hayabuchi H3, Mizoue T1. (PubMed)
(2) Antidepressive-like effects and antioxidant activity of green tea and GABA green tea in a mouse model of post-stroke depression by Di Lorenzo A1, Nabavi SF2, Sureda A3, Moghaddam AH4, Khanjani S4, Arcidiaco P5, Nabavi SM2, Daglia M1. (PubMed)
(3) Effect of green tea on reward learning in healthy individuals: a randomized, double-blind, placebo-controlled pilot study by Zhang Q1, Yang H, Wang J, Li A, Zhang W, Cui X, Wang K.(PubMed)
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