Kyle J. Norton
Appendicitis is a condition of inflammation of the appendix.
The condition is classified as an emergency, in many incidences, required the removal of the appendix.
Early diagnosis is easily treated with 100% recovery.
If burst, or perforate, spilling infectious materials into the abdominal cavity can be life-threatening.
And depending on each patient's condition, treatment of appendicitis perforate may opt to conservative treatment by means of intravenous antibiotic therapy to solve acute abdomen pain, planning a routinary interval appendectomy (IA) after some months, or an immediate appendectomy(4).
Examples are quoted directly from the joint study led by the Institute for Maternal and Child Health - IRCCS Burlo Garofolo
[Patient 1. immediate appendectomy
This 5-year-old girl showed the following symptoms: 5 days of fever, abdominal pain, and vomiting. Leukocytes and PCR were 18 × 103 and 16 (mg/dl) respectively.
The US showed perforated appendicitis associated with an inflammatory mass.
We decided to perform an immediate video-assisted appendectomy through a sub-umbilical incision for the laparoscopic operative trocar insertion.
We found a subhepatic necrotic appendix surrounded by an abscess.
To dissect and extract the appendix, it was necessary to enlarge the sub-umbilical incision and create a second access in the left iliac fossa. A nasogastric tube (NT) and vesical catheter (VC) were placed. Surgery time was 165 min.
Oral feeding started on day 4. The hospital stay was 9 days.
She was treated with triple antibiotic therapy (ampicillin/sulbactam 50 mg/kg every 8 h, metronidazole 10 mg/kg every 8 h, and tobramycin 5 mg/kg in a single dose) for 9 days.
In the postoperative stage, an infection of the sub-umbilical wound was observed.
Patient 2: immediate appendectomy
This 4-year-old girl reported having abdominal pain and fever for 3 days. Leukocytes and PCR were 24 × 103 and 20 mg/dl respectively.
The US showed a thickening of the appendix with a periodical effusion without a secure image of the abscess.
An immediate video-assisted appendectomy was performed through a single enlarged sub-umbilical incision.
We found a necrotic appendix with an inflammatory mass involving the right tube and ovary.
The tube wall was very fragile and during the procedure, a tubal lesion led to a partial tube removal. NT and VC were placed. Surgery time at 70 min.
Oral feeding started on day 3. The hospital stay was 10 days. Our standard triple antibiotic therapy was continued for 10 days.
In the postoperative stage, sub-umbilical wound infection was observed](4).
Dr. Edoardo Guida and colleagues said, " In the case of perforated appendicitis with an abscess and coprolith is an initial conservative case management followed by a routine interval appendectomy performed not later than 4 months after discharge"(4).
Therefore, to rule out perforated appendicitis, you must understand the signs and symptoms of below and act accordingly
1. Abdominal pain and upper respiratory tract infection
Although appendicitis is the condition that most commonly requires emergent abdominal surgery in the pediatric population, less than 2% of the disease occurs in infants and it is even more uncommon in neonates.
There is a report of a rare case of a 14-month-old child presenting with abdominal pain first diagnosed with upper respiratory tract infection and then admitted to the Paediatric Surgery Department with a final diagnosis of acute appendicitis, according to the FONDAZIONE IRCCS CA’ GRANDA – Ospedale Maggiore Policlinico(1).
2. Symptoms of vomiting, fever, pain, anorexia, diarrhea, abdominal tenderness, peritonitis, temperature 38.0 degrees C or more, abdominal distension, Leukocytosis, small-bowel obstruction (SBO), contrast enemas and perforated appendicitis.
According to some researchers, if you experience all these symptoms persistently over 3 days or more, you may be in the early stage of appendicitis. Please check with your doctor the right way.
The study to identify the presenting symptoms and signs in this age group and examine their subsequent management and outcome, by the Scarborough Hospital, indicated that 27 children less than 3 years old (mean 23 months) comprised 2.3% of all children with appendicitis in the series, the most common presenting symptoms were vomiting (27), fever (23), pain (21), anorexia (15), and diarrhea (11).
The average duration of symptoms was 3 days, with 4 or more days in 9 children. Eighteen children were seen by a physician before the correct diagnosis was made; 14 were initially treated for an upper respiratory tract infection, otitis media, or a urinary tract infection.
The most common presenting signs were abdominal tenderness (27), peritonitis (24), temperature 38.0 degrees C or more (21), abdominal distension (18), Leukocytosis (<12.0 x 10(3)/mm(3)) was found in 18, tenderness was localized to the right lower quadrant (RLQ) in 14 and was diffuse in 10.
Abdominal radiographs demonstrated findings of small-bowel obstruction (SBO) in 14 of 21 patients, a fecalith in 2, and a pneumoperitoneum in 1. Contrast enemas were performed in 6 children, 5 of whom had a phlegmon or an abscess. Perforated appendicitis was found in all 27 patients. An appendectomy was performed in 25 and an RLQ drain was placed in 18(2).
3. An abdominal mass, guarding, rebound tenderness, rigidity, diffuse or focal tenderness, diarrhea, emesis, fever, pain, and anorexia
According to the Children's Hospital of Philadelphia, the common physical signs of an abdominal mass, guarding, rebound tenderness, rigidity, and diffuse or focal tenderness and common symptoms are diarrhea, emesis, fever, pain, and anorexia with the most common presenting symptom was abdominal pain (94%); the most common sign was abdominal tenderness (95.8%)(3).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22878766
(2) http://www.ncbi.nlm.nih.gov/pubmed/14730382
(3) http://www.ncbi.nlm.nih.gov/pubmed/10888451
(4) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485681/
Monday, 3 July 2023
The Anti #CervicalCancer WholeFoods, According to Researchers
Kyle J. Norton
The cervix is the lower part of the uterus that opens at the top of the vagina.
The cervix acts as a transition area for the vaginal lining (squamous epithelium) to change to uterus type (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus.
Cervical cancer is a malignant neoplasm of the cervix uteri or cervical area caused by abnormal cell growth with alternation of cells DNA.
At the later stage, the cancerous cells may travel a distance away from the cervix to infect other healthy organs and tissue.
According to the statistic, every year, approximately,13,000 women in the United States are diagnosed with invasive cervical cancer, and 4,170 die from the disease.
Women between the ages of 35 and 44. are associated with a substantially increased risk of cervical cancer compared to only 15% in women over age 65.
According to cancer.net, in the early stage of cervical cancer, patients may experience some mild symptoms of blood spots or light bleeding between or following periods, and longer and heavier menstrual bleeding.
If you experience some of the symptoms above, please let your family doctor knows. Early diagnosed
is associated closely with 100% of the survival rate.
In the later stage, patients may experience symptoms of bleeding after intercourse, douching, or a pelvic examination...........and unexplained, persistent pelvic and/or back pain. If you develop the above symptoms, please see your doctor immediately.
The American cancer associate suggested that women with genetic mutation and infected by human papillomavirus (HPV) become aggressive in the induced production of proteins known as E6 and E7 which turn off some tumor suppressor genes, which maybe the cause of cervical cancer.
Please note that most women with HPV don’t get cervical cancer
Risk factors besides HPV also include immune system deficiency, herpes, smoking, age. group ... use of oral contraceptives, and exposure to diethylstilbestrol (DES).
The risk of cervical cancer is also higher in Hispanic women followed by African-Americans, Asians and Pacific Islanders, and whites(a).
Depending on the stage and grade of cancer, if the cancer is found in the early stage, a hysterectomy may not be needed.
Others, after surgery, may require chemotherapy including Cisplatin, Fluorouracil (5-FU), Mitomycin, Paclitaxel, Ifosfamide, Carboplatin, Bevacizumab, and radiotherapy if necessary,
All these chemo-drugs have been known to induce serious side effects
Epidemiological studies strongly suggested that a healthy and balanced diet improved serum levels of antioxidants and may reduce cervical neoplasia risk(b)(c)
Foods have been found effective in reducing the risk and treatment of cervical cancer., include
1. Cruciferous vegetables
Cruciferous vegetables are a group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli, etc.
Isothiocyanates, a major chemical constituent found in Cruciferous vegetables, inhibited the cell viability of human cervical cancer cells, through improvement of antioxidant status(1).
β-Phenylethyl isothiocyanate (PEITC). induced apoptosis to inhibit cell proliferation in human cervical cancer cell lines (HEp-2 and KB), through increased expression of the death receptors (DR4 and DR5) and cleaved caspase-3(2).
Other chemical compounds, such as I3C (indole-3-carbinol) and DIM (diindolylmethane) found in all types of cruciferous vegetables, demonstrated exceptional anti-cancer effects against hormone-responsive cancers such as ovarian cancers(3).
Some researchers suggested that isothiocyanates and indoles through the intake of cruciferous vegetables may decrease cancer risk, but the protective effects may be influenced by individual genetic variation (polymorphisms) in the metabolism and elimination of isothiocyanates from the body.
And in some instances, long-term exposure to sulforaphane and indole-3-carbinol (I3C), may have a negative implication in the treatment of a variety of anticarcinogenic mechanisms(4).
2. Tomato
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America.
Because of its health benefits, the tomato is grown worldwide for commercial purposes and often in the greenhouse.
Glycoalkaloid-rich green tomato extracts, according to the Seowon University inhibited proliferation of HeLa in cervical carcinoma cells through inactivation(5).
Dr. Ferguson LR, in the study of prospects for cancer prevention, suggested that fruit and vegetable servings with a total minimum of five each day, particularly in some specific fruits and vegetables (e.g., tomato, broccoli, onions) may have strong benefits against individual cancer types(6).
But, the reviews of FDA in 2004 studies which indicated an inverse association between tomato and/or lycopene intake and the risk of some types of cancer, suggested that there is no credible evidence for an association between tomato consumption and a reduced risk of lung, colorectal, breast, cervical, or endometrial cancer(7).
3. Garlic
Garlic is a natural superfood healer for its natural antibiotic with antiviral, antifungal, anticoagulant and antiseptic properties.
Diallyl sulfide (DAS), a chemical component of garlic-induced mitochondrial dysfunction, caused the release of cytochrome c for causing apoptosis in human cervical cancer Ca Ski cells(8) and cell cycle arrest and apoptosis through the p53, caspase- and mitochondria-dependent pathways in HeLa human cervical cancer cells(9).
The Defense Food Research Laboratory study indicated that garlic exerted its anticarcinogenic effect(including cervical cancer) through a number of mechanisms, including scavenging of radicals, increasing glutathione levels, and increasing the activities of enzymes(10).
In 3-methylcholanthrene (MCA)-induced carcinogenesis in the uterine cervix of virgin young adult Swiss albino mice study, researchers found that there is a significant decline in the incidence of carcinoma with oral administration of garlic at the dose level of 400 mg/kg body wt./day for 2 weeks before and 4 weeks following carcinogen thread insertion(11).
4. Ginger
Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Crude methanol and fractionated extract of the rhizomes of Alpinia pahangensis, wild ginger distributed in the lowlands of Pahang, Malaysia, showed a potent cytotoxic effect against certain cancer cell lines, including human cervical cancer cell line, Ca Ski(12).
In human cervical epithelial carcinoma (HeLa), aqueous extract of ginger (GAE) induced apoptosis of cancer cells by interacting directly with cellular microtubules and disrupting their structure(13).
Another study indicated that Benjakul [BEN], a composition of five plants: Piper Chaba fruit [PC], Piper sarmentosum root [PS], Piper interruptum stem [PI], Plumbago indica root [PL] and Zingiber officinale rhizome [ZO] in Thai herbal medicine, exerted potential cytotoxic activity against certain types of cancer cell line including cervical cancer cell line Hela(14).
5. Carrot
Carrots can grow to 3ft tall. They are root vegetables with orange color normally, a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asia and Europe.
According to Aichi Cancer Center, frequent intakes of carrots are associated with decreased risk of cervical cancer(15).
The Shandong University study in assessing the risk of cervical cancer association of vitamin A, found abundantly in carrots (retinol, carotene, and other carotenoids) indicated that vitamin A intake and blood vitamin A levels are inversely associated with the risk of cervical cancer(16).
Others in the testing of concentrations of retinol and beta carotene in serum samples taken from 113 women with cervical cancer, 32 with invasive and 81 with pre-invasive disease, and compared with those from 226 age-matched control women, scientists after taking into account of other confounders suggested that there is a significantly reduced concentration of beta carotene levels in women with pre-invasive disease compared to the control(17).
6. Dulse
Dulse is a red seaweed of genus Palmaria, belongings to Family Palmariaceae that grows attached to rocks by a "holdfast" in the North Atlantic and Northwest Pacific.
Seaweed is commonly used in Ireland and Atlantic Canada both as food and medicine. Today, dulses are now shipped around the globe for commercial benefits because of their health benefits
And fried dulses can be found in many health food stores or fish markets or can be ordered directly from local distributors.
Ryerson University's study of the extracts from a variety of edible seaweeds showed a positive effect of dulse polyphenols in inhibited cell proliferation in the human cervical adenocarcinoma cell line (HeLa cells) through its antioxidant activity(18)(19).
Fucoxanthin found abundantly in dulse, in the study by Henan University, displayed an autophagy-dependent cytotoxic effect in cervical cancer cell lines HeLa cells via inhibition of Akt/mTOR signaling pathway(20).
8. Strawberry
Strawberries are a genius of Fragaria × ananassa belongings to the family Rosaceae.
The fruits have been grown all over the world in a suitable climate for commercial profits and health benefits.
The studies of the effects of a variety of berry extracts in human cervical cancer (HeLa) cells, indicated that
* Tannin-rich fraction of procyanidins of the strawberry extract are most potent in comparison with other berries(21).
* The extract of Strawberry, Blueberry, and Raspberry extract. showed a positive effect in inhibited CaSki and SiHa cervical cancer cell lines(22).
9. Grape and Red wine
Grape is a woody vine of the genus Vitis, belongings to the family Vitaceae, native to southern Turkey.
Grape extracts were found to interact effectively with decaffeinated green tea extracts both in the inhibition of tNOX activity and in the inhibition of cancer cell growth(23).
Red and white wine polyphenols and resveratrol exerted higher cytotoxic activity against HeLabut white wine polyphenolic extract exhibited a significantly higher antiproliferative action on cancer cell lines than red wine extract(24).
10. Cactus pear
Cactus pear also known as Prickly pear is a genus Opuntia, belongings to the family Cactaceae, native to Mexico.
Cactus pear extracts, in the study of immortalized ovarian and ovarian cancer cells (OVCA420, SKOV3), exhibited an anti-proliferative effect through a dramatic increase of reactive oxygen species (ROS),(25).
A study from the University of Arizona indicated that aqueous extracts of cactus pear significantly increased apoptosis and growth inhibition in both immortalized epithelial cells and cancer cells in a dose- and time-dependent manner through cell cycle arrest(26).
11. Vitis coignetiae Pulliat
Vitis coignetiae Pulliat also known as Yamabudo, Crimson Glory Vine, is the genus Viti, belongings to the family Vitaceae, native to the temperate climes of Asia.
It has been used as a healthy juice and wine because of the abundant polyphenols and anthocyanins.
Anthocyanins isolated from fruits of Vitis coignetiae Pulliat (AIMs), inhibited the invasion of HeLa cells in a dose-dependent manner,(26).
The stem extracts from Greek Vitis vinifera varieties of the total polyphenolic content (TPC) inhibited at low concentrations, the growth of HepG2 and HeLa cancer cells compared to those of seed extracts(27)(28).
Taken altogether, without going into reviews, the list of foods above may be potent in reducing the risk and treatment of cervical cancer. But further studies with large sample sizes and multi-centers are necessary to improve the validation of these claims.
However, some researchers argued that the role of diet and nutrition in the etiology of cervical cancer is not yet resolved(d).
And, the Catalan Institute of Oncology study showed statistically nonsignificant inverse associations were observed for leafy vegetables, root vegetables, garlic and onions, citrus fruits, vitamin C, vitamin E, and retinol for invasive squamous cervical cancer (ISC)(e).
As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Cervical cancer (American cancer society)
(b) Diet and serum micronutrients in relation to cervical neoplasia and cancer among low-income Brazilian women by Tomita LY1, Longatto Filho A, Costa MC, Andreoli MA, Villa LL, Franco EL, Cardoso MA; Brazilian Investigation into Nutrition and Cervical Cancer Prevention (BRINCA) Study Team. (PubMed)
(c) Associations of dietary dark-green and deep-yellow vegetables and fruits with cervical intraepithelial neoplasia: modification by smoking by Tomita LY1, Roteli-Martins CM, Villa LL, Franco EL, Cardoso MA; BRINCA Study Team. (PubMed)
(d) Diet and the risk of in situ cervical cancer among white women in the United States by Ziegler RG1, Jones CJ, Brinton LA, Norman SA, Mallin K, Levine RS, Lehman HF, Hamman RF, Trumble AC, Rosenthal JF, et al.(PubMed)
(e) Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study by González CA1, Travier N, Luján-Barroso L, Castellsagué X, Bosch FX, Roura E, Bueno-de-Mesquita HB, Palli D, Boeing H, Pala V, Sacerdote C, Tumino R, Panico S, Manjer J, Dillner J, Hallmans G, Kjellberg L, Sanchez MJ, Altzibar JM, Barricarte A, Navarro C, Rodriguez L, Allen N, Key TJ, Kaaks R, Rohrmann S, Overvad K, Olsen A, Tjønneland A, Munk C, Kjaer SK, Peeters PH, van Duijnhoven FJ, Clavel-Chapelon F, Boutron-Ruault MC, Trichopoulou A, Benetou V, Naska A, Lund E, Engeset D, Skeie G, Franceschi S, Slimani N, Rinaldi S, Riboli E.(PubMed)
(1) The anti-oxidant properties of isothiocyanates: a review by de Figueiredo SM1, Filho SA, Nogueira-Machado JA, Caligiorne RB. (PubMed)
(2) Effect of β-phenylethyl isothiocyanate from cruciferous vegetables on growth inhibition and apoptosis of cervical cancer cells through the induction of death receptors 4 and 5 by Huong le D1, Shim JH, Choi KH, Shin JA, Choi ES, Kim HS, Lee SJ, Kim SJ, Cho NP, Cho SD(PubMed)
(3) Chemopreventive properties of indole-3-carbinol, diindolylmethane and other constituents of cardamom against carcinogenesis by Acharya A1, Das I, Singh S, Saha T.(PubMed)
(4) Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis by Higdon JV1, Delage B, Williams DE, Dashwood RH. (PubMed)
(5) Changes in free amino acid, phenolic, chlorophyll, carotenoid, and glycoalkaloid contents in tomatoes during 11 stages of growth and inhibition of cervical and lung human cancer cells by green tomato extracts by Choi SH1, Lee SH, Kim HJ, Lee IS, Kozukue N, Levin CE, Friedman M.(PubMed)
(6) Prospects for cancer prevention by Ferguson LR. (PubMed)
(7) The U.S. Food and Drug Administration's evidence-based review for qualified health claims: tomatoes, lycopene, and cancer by Kavanaugh CJ1, Trumbo PR, Ellwood KC. (PubMed)
(8) Diallyl sulfide promotes cell-cycle arrest through the p53 expression and triggers induction of apoptosis via caspase- and mitochondria-dependent signaling pathways in human cervical cancer Ca Ski cells by Chiu TH1, Lan KY, Yang MD, Lin JJ, Hsia TC, Wu CT, Yang JS, Chueh FS, Chung JG. (PubMed)
(9) Diallyl sulfide induces cell cycle arrest and apoptosis in HeLa human cervical cancer cells through the p53, caspase- and mitochondria-dependent pathways by Wu PP1, Chung HW, Liu KC, Wu RS, Yang JS, Tang NY, Lo C, Hsia TC, Yu CC, Chueh FS, Lin SS, Chung JG.(PubMed)
(10) Anticarcinogenic properties of garlic: a review by Khanum F1, Anilakumar KR, Viswanathan KR.(PubMed)
(11) Chemopreventive action of garlic on methylcholanthrene-induced carcinogenesis in the uterine cervix of mice by Hussain SP1, Jannu LN, Rao AR.(PubMed)
(12) Antioxidant potential, cytotoxic activity and total phenolic content of Alpinia pahangensis rhizomes by Phang CW1, Malek SN, Ibrahim H.(PubMed)
(13) Aqueous extract of ginger shows antiproliferative activity through disruption of microtubule network of cancer cells by Choudhury D1, Das A, Bhattacharya A, Chakrabarti G.(PubMed)
(14) In vitro cytotoxic activity of Benjakul herbal preparation and its active compounds against human lung, cervical and liver cancer cells by Ruangnoo S1, Itharat A, Sakpakdeejaroen I, Rattarom R, Tappayutpijam P, Pawa KK.(PubMed)
(15) [Hospital epidemiology--a comparative case control study of breast and cervical cancers].
[Article in Japanese] by Tajima K1, Hirose K, Ogawa H, Yoshida M, Ohta M.(PubMed)
(16) Vitamin A and risk of cervical cancer: a meta-analysis by Zhang X1, Dai B, Zhang B, Wang Z.(PubMed)
(17) Cancer of the cervix uteri and vitamin A by Harris RW, Forman D, Doll R, Vessey MP, Wald NJ.(PubMed)
(18) Antioxidant and antiproliferative activities of extracts from a variety of edible seaweeds by Yuan YV1, Walsh NA.(PubMed)
(19) Extracts from dulse (Palmaria palmata) are effective antioxidants and inhibitors of cell proliferation in vitro. by Yuan YV1, Carrington MF, Walsh NA.(PubMed)
(20) Essential role of autophagy in fucoxanthin-induced cytotoxicity to human epithelial cervical cancer HeLa cells by Hou LL1, Gao C, Chen L, Hu GQ, Xie SQ.(PubMed)
(21) Berry extracts exert different antiproliferative effects against cervicaland colon cancer cells grown in vitro by McDougall GJ1, Ross HA, Ikeji M, Stewart D.(PubMed)
(22) Anticarcinogenic Activity of Strawberry, Blueberry, and Raspberry Extracts to Breast and Cervical Cancer Cells. by Wedge DE1, Meepagala KM, Magee JB, Smith SH, Huang G, Larcom LL.(PubMed)
(23) Anticancer activity of grape and grape skin extracts alone and combined with green tea infusions by Morré DM1, Morré DJ.(PubMed)
(24) Cytotoxic effect of wine polyphenolic extracts and resveratrol against human carcinoma cells and normal peripheral blood mononuclear cells by Matić I1, Zizak Z, Simonović M, Simonović B, Godevac D, Savikin K, Juranić Z.(PubMed)
(25) Cactus pear extracts induce reactive oxygen species production and apoptosis in ovarian cancer cells by Feugang JM1, Ye F, Zhang DY, Yu Y, Zhong M, Zhang S, Zou C.(PubMed)
(26) Cactus pear: a natural product in cancer chemoprevention by Zou DM1, Brewer M, Garcia F, Feugang JM, Wang J, Zang R, Liu H, Zou C.(PubMed)
(27) Anthocyanins from Vitis coignetiae Pulliat Inhibit Cancer Invasion and Epithelial-Mesenchymal Transition, but These Effects Can Be Attenuated by Tumor Necrosis Factor in Human Uterine Cervical Cancer HeLa Cells by Lu JN1, Lee WS, Yun JW, Kim MJ, Kim HJ, Kim DC, Jeong JH, Choi YH, Kim GS, Ryu CH, Shin SC.(PubMed)
(28) Assessment of polyphenolic content, antioxidant activity, protection against ROS-induced DNA damage and anticancer activity of Vitis vinifera stem extracts by Apostolou A1, Stagos D, Galitsiou E, Spyrou A, Haroutounian S, Portesis N, Trizoglou I, Wallace Hayes A, Tsatsakis AM, Kouretas D.
The cervix is the lower part of the uterus that opens at the top of the vagina.
The cervix acts as a transition area for the vaginal lining (squamous epithelium) to change to uterus type (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus.
Cervical cancer is a malignant neoplasm of the cervix uteri or cervical area caused by abnormal cell growth with alternation of cells DNA.
At the later stage, the cancerous cells may travel a distance away from the cervix to infect other healthy organs and tissue.
According to the statistic, every year, approximately,13,000 women in the United States are diagnosed with invasive cervical cancer, and 4,170 die from the disease.
Women between the ages of 35 and 44. are associated with a substantially increased risk of cervical cancer compared to only 15% in women over age 65.
According to cancer.net, in the early stage of cervical cancer, patients may experience some mild symptoms of blood spots or light bleeding between or following periods, and longer and heavier menstrual bleeding.
If you experience some of the symptoms above, please let your family doctor knows. Early diagnosed
is associated closely with 100% of the survival rate.
In the later stage, patients may experience symptoms of bleeding after intercourse, douching, or a pelvic examination...........and unexplained, persistent pelvic and/or back pain. If you develop the above symptoms, please see your doctor immediately.
The American cancer associate suggested that women with genetic mutation and infected by human papillomavirus (HPV) become aggressive in the induced production of proteins known as E6 and E7 which turn off some tumor suppressor genes, which maybe the cause of cervical cancer.
Please note that most women with HPV don’t get cervical cancer
Risk factors besides HPV also include immune system deficiency, herpes, smoking, age. group ... use of oral contraceptives, and exposure to diethylstilbestrol (DES).
The risk of cervical cancer is also higher in Hispanic women followed by African-Americans, Asians and Pacific Islanders, and whites(a).
Depending on the stage and grade of cancer, if the cancer is found in the early stage, a hysterectomy may not be needed.
Others, after surgery, may require chemotherapy including Cisplatin, Fluorouracil (5-FU), Mitomycin, Paclitaxel, Ifosfamide, Carboplatin, Bevacizumab, and radiotherapy if necessary,
All these chemo-drugs have been known to induce serious side effects
Epidemiological studies strongly suggested that a healthy and balanced diet improved serum levels of antioxidants and may reduce cervical neoplasia risk(b)(c)
Foods have been found effective in reducing the risk and treatment of cervical cancer., include
1. Cruciferous vegetables
Cruciferous vegetables are a group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli, etc.
Isothiocyanates, a major chemical constituent found in Cruciferous vegetables, inhibited the cell viability of human cervical cancer cells, through improvement of antioxidant status(1).
β-Phenylethyl isothiocyanate (PEITC). induced apoptosis to inhibit cell proliferation in human cervical cancer cell lines (HEp-2 and KB), through increased expression of the death receptors (DR4 and DR5) and cleaved caspase-3(2).
Other chemical compounds, such as I3C (indole-3-carbinol) and DIM (diindolylmethane) found in all types of cruciferous vegetables, demonstrated exceptional anti-cancer effects against hormone-responsive cancers such as ovarian cancers(3).
Some researchers suggested that isothiocyanates and indoles through the intake of cruciferous vegetables may decrease cancer risk, but the protective effects may be influenced by individual genetic variation (polymorphisms) in the metabolism and elimination of isothiocyanates from the body.
And in some instances, long-term exposure to sulforaphane and indole-3-carbinol (I3C), may have a negative implication in the treatment of a variety of anticarcinogenic mechanisms(4).
2. Tomato
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America.
Because of its health benefits, the tomato is grown worldwide for commercial purposes and often in the greenhouse.
Glycoalkaloid-rich green tomato extracts, according to the Seowon University inhibited proliferation of HeLa in cervical carcinoma cells through inactivation(5).
Dr. Ferguson LR, in the study of prospects for cancer prevention, suggested that fruit and vegetable servings with a total minimum of five each day, particularly in some specific fruits and vegetables (e.g., tomato, broccoli, onions) may have strong benefits against individual cancer types(6).
But, the reviews of FDA in 2004 studies which indicated an inverse association between tomato and/or lycopene intake and the risk of some types of cancer, suggested that there is no credible evidence for an association between tomato consumption and a reduced risk of lung, colorectal, breast, cervical, or endometrial cancer(7).
3. Garlic
Garlic is a natural superfood healer for its natural antibiotic with antiviral, antifungal, anticoagulant and antiseptic properties.
Diallyl sulfide (DAS), a chemical component of garlic-induced mitochondrial dysfunction, caused the release of cytochrome c for causing apoptosis in human cervical cancer Ca Ski cells(8) and cell cycle arrest and apoptosis through the p53, caspase- and mitochondria-dependent pathways in HeLa human cervical cancer cells(9).
The Defense Food Research Laboratory study indicated that garlic exerted its anticarcinogenic effect(including cervical cancer) through a number of mechanisms, including scavenging of radicals, increasing glutathione levels, and increasing the activities of enzymes(10).
In 3-methylcholanthrene (MCA)-induced carcinogenesis in the uterine cervix of virgin young adult Swiss albino mice study, researchers found that there is a significant decline in the incidence of carcinoma with oral administration of garlic at the dose level of 400 mg/kg body wt./day for 2 weeks before and 4 weeks following carcinogen thread insertion(11).
4. Ginger
Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Crude methanol and fractionated extract of the rhizomes of Alpinia pahangensis, wild ginger distributed in the lowlands of Pahang, Malaysia, showed a potent cytotoxic effect against certain cancer cell lines, including human cervical cancer cell line, Ca Ski(12).
In human cervical epithelial carcinoma (HeLa), aqueous extract of ginger (GAE) induced apoptosis of cancer cells by interacting directly with cellular microtubules and disrupting their structure(13).
Another study indicated that Benjakul [BEN], a composition of five plants: Piper Chaba fruit [PC], Piper sarmentosum root [PS], Piper interruptum stem [PI], Plumbago indica root [PL] and Zingiber officinale rhizome [ZO] in Thai herbal medicine, exerted potential cytotoxic activity against certain types of cancer cell line including cervical cancer cell line Hela(14).
5. Carrot
Carrots can grow to 3ft tall. They are root vegetables with orange color normally, a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asia and Europe.
According to Aichi Cancer Center, frequent intakes of carrots are associated with decreased risk of cervical cancer(15).
The Shandong University study in assessing the risk of cervical cancer association of vitamin A, found abundantly in carrots (retinol, carotene, and other carotenoids) indicated that vitamin A intake and blood vitamin A levels are inversely associated with the risk of cervical cancer(16).
Others in the testing of concentrations of retinol and beta carotene in serum samples taken from 113 women with cervical cancer, 32 with invasive and 81 with pre-invasive disease, and compared with those from 226 age-matched control women, scientists after taking into account of other confounders suggested that there is a significantly reduced concentration of beta carotene levels in women with pre-invasive disease compared to the control(17).
6. Dulse
Dulse is a red seaweed of genus Palmaria, belongings to Family Palmariaceae that grows attached to rocks by a "holdfast" in the North Atlantic and Northwest Pacific.
Seaweed is commonly used in Ireland and Atlantic Canada both as food and medicine. Today, dulses are now shipped around the globe for commercial benefits because of their health benefits
And fried dulses can be found in many health food stores or fish markets or can be ordered directly from local distributors.
Ryerson University's study of the extracts from a variety of edible seaweeds showed a positive effect of dulse polyphenols in inhibited cell proliferation in the human cervical adenocarcinoma cell line (HeLa cells) through its antioxidant activity(18)(19).
Fucoxanthin found abundantly in dulse, in the study by Henan University, displayed an autophagy-dependent cytotoxic effect in cervical cancer cell lines HeLa cells via inhibition of Akt/mTOR signaling pathway(20).
8. Strawberry
Strawberries are a genius of Fragaria × ananassa belongings to the family Rosaceae.
The fruits have been grown all over the world in a suitable climate for commercial profits and health benefits.
The studies of the effects of a variety of berry extracts in human cervical cancer (HeLa) cells, indicated that
* Tannin-rich fraction of procyanidins of the strawberry extract are most potent in comparison with other berries(21).
* The extract of Strawberry, Blueberry, and Raspberry extract. showed a positive effect in inhibited CaSki and SiHa cervical cancer cell lines(22).
9. Grape and Red wine
Grape is a woody vine of the genus Vitis, belongings to the family Vitaceae, native to southern Turkey.
Grape extracts were found to interact effectively with decaffeinated green tea extracts both in the inhibition of tNOX activity and in the inhibition of cancer cell growth(23).
Red and white wine polyphenols and resveratrol exerted higher cytotoxic activity against HeLabut white wine polyphenolic extract exhibited a significantly higher antiproliferative action on cancer cell lines than red wine extract(24).
10. Cactus pear
Cactus pear also known as Prickly pear is a genus Opuntia, belongings to the family Cactaceae, native to Mexico.
Cactus pear extracts, in the study of immortalized ovarian and ovarian cancer cells (OVCA420, SKOV3), exhibited an anti-proliferative effect through a dramatic increase of reactive oxygen species (ROS),(25).
A study from the University of Arizona indicated that aqueous extracts of cactus pear significantly increased apoptosis and growth inhibition in both immortalized epithelial cells and cancer cells in a dose- and time-dependent manner through cell cycle arrest(26).
11. Vitis coignetiae Pulliat
Vitis coignetiae Pulliat also known as Yamabudo, Crimson Glory Vine, is the genus Viti, belongings to the family Vitaceae, native to the temperate climes of Asia.
It has been used as a healthy juice and wine because of the abundant polyphenols and anthocyanins.
Anthocyanins isolated from fruits of Vitis coignetiae Pulliat (AIMs), inhibited the invasion of HeLa cells in a dose-dependent manner,(26).
The stem extracts from Greek Vitis vinifera varieties of the total polyphenolic content (TPC) inhibited at low concentrations, the growth of HepG2 and HeLa cancer cells compared to those of seed extracts(27)(28).
Taken altogether, without going into reviews, the list of foods above may be potent in reducing the risk and treatment of cervical cancer. But further studies with large sample sizes and multi-centers are necessary to improve the validation of these claims.
However, some researchers argued that the role of diet and nutrition in the etiology of cervical cancer is not yet resolved(d).
And, the Catalan Institute of Oncology study showed statistically nonsignificant inverse associations were observed for leafy vegetables, root vegetables, garlic and onions, citrus fruits, vitamin C, vitamin E, and retinol for invasive squamous cervical cancer (ISC)(e).
As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Cervical cancer (American cancer society)
(b) Diet and serum micronutrients in relation to cervical neoplasia and cancer among low-income Brazilian women by Tomita LY1, Longatto Filho A, Costa MC, Andreoli MA, Villa LL, Franco EL, Cardoso MA; Brazilian Investigation into Nutrition and Cervical Cancer Prevention (BRINCA) Study Team. (PubMed)
(c) Associations of dietary dark-green and deep-yellow vegetables and fruits with cervical intraepithelial neoplasia: modification by smoking by Tomita LY1, Roteli-Martins CM, Villa LL, Franco EL, Cardoso MA; BRINCA Study Team. (PubMed)
(d) Diet and the risk of in situ cervical cancer among white women in the United States by Ziegler RG1, Jones CJ, Brinton LA, Norman SA, Mallin K, Levine RS, Lehman HF, Hamman RF, Trumble AC, Rosenthal JF, et al.(PubMed)
(e) Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study by González CA1, Travier N, Luján-Barroso L, Castellsagué X, Bosch FX, Roura E, Bueno-de-Mesquita HB, Palli D, Boeing H, Pala V, Sacerdote C, Tumino R, Panico S, Manjer J, Dillner J, Hallmans G, Kjellberg L, Sanchez MJ, Altzibar JM, Barricarte A, Navarro C, Rodriguez L, Allen N, Key TJ, Kaaks R, Rohrmann S, Overvad K, Olsen A, Tjønneland A, Munk C, Kjaer SK, Peeters PH, van Duijnhoven FJ, Clavel-Chapelon F, Boutron-Ruault MC, Trichopoulou A, Benetou V, Naska A, Lund E, Engeset D, Skeie G, Franceschi S, Slimani N, Rinaldi S, Riboli E.(PubMed)
(1) The anti-oxidant properties of isothiocyanates: a review by de Figueiredo SM1, Filho SA, Nogueira-Machado JA, Caligiorne RB. (PubMed)
(2) Effect of β-phenylethyl isothiocyanate from cruciferous vegetables on growth inhibition and apoptosis of cervical cancer cells through the induction of death receptors 4 and 5 by Huong le D1, Shim JH, Choi KH, Shin JA, Choi ES, Kim HS, Lee SJ, Kim SJ, Cho NP, Cho SD(PubMed)
(3) Chemopreventive properties of indole-3-carbinol, diindolylmethane and other constituents of cardamom against carcinogenesis by Acharya A1, Das I, Singh S, Saha T.(PubMed)
(4) Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis by Higdon JV1, Delage B, Williams DE, Dashwood RH. (PubMed)
(5) Changes in free amino acid, phenolic, chlorophyll, carotenoid, and glycoalkaloid contents in tomatoes during 11 stages of growth and inhibition of cervical and lung human cancer cells by green tomato extracts by Choi SH1, Lee SH, Kim HJ, Lee IS, Kozukue N, Levin CE, Friedman M.(PubMed)
(6) Prospects for cancer prevention by Ferguson LR. (PubMed)
(7) The U.S. Food and Drug Administration's evidence-based review for qualified health claims: tomatoes, lycopene, and cancer by Kavanaugh CJ1, Trumbo PR, Ellwood KC. (PubMed)
(8) Diallyl sulfide promotes cell-cycle arrest through the p53 expression and triggers induction of apoptosis via caspase- and mitochondria-dependent signaling pathways in human cervical cancer Ca Ski cells by Chiu TH1, Lan KY, Yang MD, Lin JJ, Hsia TC, Wu CT, Yang JS, Chueh FS, Chung JG. (PubMed)
(9) Diallyl sulfide induces cell cycle arrest and apoptosis in HeLa human cervical cancer cells through the p53, caspase- and mitochondria-dependent pathways by Wu PP1, Chung HW, Liu KC, Wu RS, Yang JS, Tang NY, Lo C, Hsia TC, Yu CC, Chueh FS, Lin SS, Chung JG.(PubMed)
(10) Anticarcinogenic properties of garlic: a review by Khanum F1, Anilakumar KR, Viswanathan KR.(PubMed)
(11) Chemopreventive action of garlic on methylcholanthrene-induced carcinogenesis in the uterine cervix of mice by Hussain SP1, Jannu LN, Rao AR.(PubMed)
(12) Antioxidant potential, cytotoxic activity and total phenolic content of Alpinia pahangensis rhizomes by Phang CW1, Malek SN, Ibrahim H.(PubMed)
(13) Aqueous extract of ginger shows antiproliferative activity through disruption of microtubule network of cancer cells by Choudhury D1, Das A, Bhattacharya A, Chakrabarti G.(PubMed)
(14) In vitro cytotoxic activity of Benjakul herbal preparation and its active compounds against human lung, cervical and liver cancer cells by Ruangnoo S1, Itharat A, Sakpakdeejaroen I, Rattarom R, Tappayutpijam P, Pawa KK.(PubMed)
(15) [Hospital epidemiology--a comparative case control study of breast and cervical cancers].
[Article in Japanese] by Tajima K1, Hirose K, Ogawa H, Yoshida M, Ohta M.(PubMed)
(16) Vitamin A and risk of cervical cancer: a meta-analysis by Zhang X1, Dai B, Zhang B, Wang Z.(PubMed)
(17) Cancer of the cervix uteri and vitamin A by Harris RW, Forman D, Doll R, Vessey MP, Wald NJ.(PubMed)
(18) Antioxidant and antiproliferative activities of extracts from a variety of edible seaweeds by Yuan YV1, Walsh NA.(PubMed)
(19) Extracts from dulse (Palmaria palmata) are effective antioxidants and inhibitors of cell proliferation in vitro. by Yuan YV1, Carrington MF, Walsh NA.(PubMed)
(20) Essential role of autophagy in fucoxanthin-induced cytotoxicity to human epithelial cervical cancer HeLa cells by Hou LL1, Gao C, Chen L, Hu GQ, Xie SQ.(PubMed)
(21) Berry extracts exert different antiproliferative effects against cervicaland colon cancer cells grown in vitro by McDougall GJ1, Ross HA, Ikeji M, Stewart D.(PubMed)
(22) Anticarcinogenic Activity of Strawberry, Blueberry, and Raspberry Extracts to Breast and Cervical Cancer Cells. by Wedge DE1, Meepagala KM, Magee JB, Smith SH, Huang G, Larcom LL.(PubMed)
(23) Anticancer activity of grape and grape skin extracts alone and combined with green tea infusions by Morré DM1, Morré DJ.(PubMed)
(24) Cytotoxic effect of wine polyphenolic extracts and resveratrol against human carcinoma cells and normal peripheral blood mononuclear cells by Matić I1, Zizak Z, Simonović M, Simonović B, Godevac D, Savikin K, Juranić Z.(PubMed)
(25) Cactus pear extracts induce reactive oxygen species production and apoptosis in ovarian cancer cells by Feugang JM1, Ye F, Zhang DY, Yu Y, Zhong M, Zhang S, Zou C.(PubMed)
(26) Cactus pear: a natural product in cancer chemoprevention by Zou DM1, Brewer M, Garcia F, Feugang JM, Wang J, Zang R, Liu H, Zou C.(PubMed)
(27) Anthocyanins from Vitis coignetiae Pulliat Inhibit Cancer Invasion and Epithelial-Mesenchymal Transition, but These Effects Can Be Attenuated by Tumor Necrosis Factor in Human Uterine Cervical Cancer HeLa Cells by Lu JN1, Lee WS, Yun JW, Kim MJ, Kim HJ, Kim DC, Jeong JH, Choi YH, Kim GS, Ryu CH, Shin SC.(PubMed)
(28) Assessment of polyphenolic content, antioxidant activity, protection against ROS-induced DNA damage and anticancer activity of Vitis vinifera stem extracts by Apostolou A1, Stagos D, Galitsiou E, Spyrou A, Haroutounian S, Portesis N, Trizoglou I, Wallace Hayes A, Tsatsakis AM, Kouretas D.
The Anti #OverGrowth of #CandidaAlbicans #Vitamins, According to Studies
Kyle J. Norton
Candida albicans are members of a large group of microorganisms whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.
Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).
According to a joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8), and overexpression of genes(9)(10) are often associated with increased candida resistance toward antifungal drugs.
NADPH oxidase (NOX) are enzymes that generate reactive oxygen species by transporting electrons across lipid membranes. to induce cytotoxicity against invading microbes. However, according to the joint study led by Johns Hopkins University Bloomberg School of Public Health, Candida albicans is capable of a ROS burst, using a member of the NOX enzyme family to produce ROS with an aim to drive fungal morphogenesis in the animal host(a).
Vitamin A, B2, C, and E as antioxidants and free radical scavengers may have a potential role in inhibited superoxide anion (ROS) radicals caused by overexpression of candida via NADPH oxidase (NOX) enzymes(b).
The Anti Over Growth of Candida Albivans Vitamins
1. Vitamin B2
Vitamin B2 required for a wide variety of cellular processes plays a key role in energy metabolism and enhances the digestive system in absorbing nutrients and supports the immune system(230)(231) in fighting against bacteria causes of inflammatory disease, including candida(232).
2. Vitamin C
Vitamin C, a water-soluble vitamin and an antioxidant found in high concentrations in immune cells is not only important in aiding the digestive system in absorbing nutrients but also enhances the production of white blood cells (233)(234) of the immune system(235) in protection of the body by binding to the harmful bacteria(236) and ingesting them.
3. Vitamin A
Retinoic acid appears to maintain normal skin health by switching on genes and differentiating keratinocytes (immature skin cells)(237) into mature epidermal cells and helps to detox the liver(238).
The vitamin also enhances the immune system(239)(240) in protecting our body through its antimicrobial functions, including Candida albicans(241).
4. Vitamin E
Vitamin E is a fat-soluble compound that included both tocopherols and tocotrienols. It not only is a polyphenol antioxidant (242)(246) in scavenging free radicals and microorganisms but also promotes the immune system is enhanced functions of B-cells(244)(245), the immune cells(245)(247) in the production of antibodies to destroy infectious agents.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(a) Candida albicans FRE8 encodes a member of the NADPH oxidase family that produces a burst of ROS during fungal morphogenesis by Rossi DCP1, Gleason JE1, Sanchez H2, Schatzman SS1, Culbertson EM1, Johnson CJ2, McNees CA1, Coelho C3, Nett JE2, Andes DR2, Cormack BP4, Culotta VC(PubMed)
(b) Free radical scavenging and antiproliferative properties of Biginelli adducts by da Silva DL1, Reis FS, Muniz DR, Ruiz AL, de Carvalho JE, Sabino AA, Modolo LV, de Fátima A(PubMed)
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ. (PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeast species. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in the yeast Candida by Prasad R1, Kapoor K.(PubMed)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of the antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(230) Edible mushrooms: improving human health and promoting quality life by Valverde ME1, Hernández-Pérez T1, Paredes-López O1.(PubMed)
(231) [Effect of some vitamins on the activity of immunocompetent cells].[Article in Russian]by Nezgovorov DV. (PubMed)
(232) Antioxidants keep the potentially probiotic but highly oxygen-sensitive human gut bacterium Faecalibacterium prausnitzii alive in ambient air by Khan MT1, van Dijl JM1, Harmsen HJ1. (PubMed)
(233) Storing red blood cells with vitamin C and N-acetylcysteine prevents oxidative stress-related lesions: a metabolomics overview by Pallotta V1, Gevi F1, D'alessandro A1, Zolla L1. (PubMed)
(234) Red blood cell metabolism under prolonged anaerobic storage by D'Alessandro A1, Gevi F, Zolla L.(PubMed)
(235) Alterations in the antioxidant defense system of workers chronically exposed to arsenic, cadmium, and mercury from coal flying ash by Zeneli L1, Sekovanić A, Ajvazi M, Kurti L, Daci N.(PubMed)(236) Indomethacin-induced translocation of bacteria across enteric epithelia is reactive oxygen species-dependent and reduced by vitamin C by Schoultz I1, McKay CM, Graepel R, Phan VC, Wang A, Söderholm J, McKay DM. (PubMed)
(237) Vitamin C derivative ascorbyl palmitate promotes ultraviolet-B-induced lipid peroxidation and cytotoxicity in keratinocytes by Meves A1, Stock SN, Beyerle A, Pittelkow MR, Peus D.(PubMed)
238. Effects of dried fish on antioxidant levels in rat liver by Anilakumar KR1, Khanum F, Krishna KR, Viswanathan KR. (PubMed)
(239) Vitamin A and retinoic acid in T cell-related immunity by Ross AC1.(PubMed)
(240) Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance by Cassani B1, Villablanca EJ, De Calisto J, Wang S, Mora JR.(PubMed)
Candida albicans are members of a large group of microorganisms whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.
Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).
According to a joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8), and overexpression of genes(9)(10) are often associated with increased candida resistance toward antifungal drugs.
NADPH oxidase (NOX) are enzymes that generate reactive oxygen species by transporting electrons across lipid membranes. to induce cytotoxicity against invading microbes. However, according to the joint study led by Johns Hopkins University Bloomberg School of Public Health, Candida albicans is capable of a ROS burst, using a member of the NOX enzyme family to produce ROS with an aim to drive fungal morphogenesis in the animal host(a).
Vitamin A, B2, C, and E as antioxidants and free radical scavengers may have a potential role in inhibited superoxide anion (ROS) radicals caused by overexpression of candida via NADPH oxidase (NOX) enzymes(b).
The Anti Over Growth of Candida Albivans Vitamins
1. Vitamin B2
Vitamin B2 required for a wide variety of cellular processes plays a key role in energy metabolism and enhances the digestive system in absorbing nutrients and supports the immune system(230)(231) in fighting against bacteria causes of inflammatory disease, including candida(232).
2. Vitamin C
Vitamin C, a water-soluble vitamin and an antioxidant found in high concentrations in immune cells is not only important in aiding the digestive system in absorbing nutrients but also enhances the production of white blood cells (233)(234) of the immune system(235) in protection of the body by binding to the harmful bacteria(236) and ingesting them.
3. Vitamin A
Retinoic acid appears to maintain normal skin health by switching on genes and differentiating keratinocytes (immature skin cells)(237) into mature epidermal cells and helps to detox the liver(238).
The vitamin also enhances the immune system(239)(240) in protecting our body through its antimicrobial functions, including Candida albicans(241).
4. Vitamin E
Vitamin E is a fat-soluble compound that included both tocopherols and tocotrienols. It not only is a polyphenol antioxidant (242)(246) in scavenging free radicals and microorganisms but also promotes the immune system is enhanced functions of B-cells(244)(245), the immune cells(245)(247) in the production of antibodies to destroy infectious agents.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(a) Candida albicans FRE8 encodes a member of the NADPH oxidase family that produces a burst of ROS during fungal morphogenesis by Rossi DCP1, Gleason JE1, Sanchez H2, Schatzman SS1, Culbertson EM1, Johnson CJ2, McNees CA1, Coelho C3, Nett JE2, Andes DR2, Cormack BP4, Culotta VC(PubMed)
(b) Free radical scavenging and antiproliferative properties of Biginelli adducts by da Silva DL1, Reis FS, Muniz DR, Ruiz AL, de Carvalho JE, Sabino AA, Modolo LV, de Fátima A(PubMed)
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ. (PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeast species. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in the yeast Candida by Prasad R1, Kapoor K.(PubMed)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of the antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(230) Edible mushrooms: improving human health and promoting quality life by Valverde ME1, Hernández-Pérez T1, Paredes-López O1.(PubMed)
(231) [Effect of some vitamins on the activity of immunocompetent cells].[Article in Russian]by Nezgovorov DV. (PubMed)
(232) Antioxidants keep the potentially probiotic but highly oxygen-sensitive human gut bacterium Faecalibacterium prausnitzii alive in ambient air by Khan MT1, van Dijl JM1, Harmsen HJ1. (PubMed)
(233) Storing red blood cells with vitamin C and N-acetylcysteine prevents oxidative stress-related lesions: a metabolomics overview by Pallotta V1, Gevi F1, D'alessandro A1, Zolla L1. (PubMed)
(234) Red blood cell metabolism under prolonged anaerobic storage by D'Alessandro A1, Gevi F, Zolla L.(PubMed)
(235) Alterations in the antioxidant defense system of workers chronically exposed to arsenic, cadmium, and mercury from coal flying ash by Zeneli L1, Sekovanić A, Ajvazi M, Kurti L, Daci N.(PubMed)(236) Indomethacin-induced translocation of bacteria across enteric epithelia is reactive oxygen species-dependent and reduced by vitamin C by Schoultz I1, McKay CM, Graepel R, Phan VC, Wang A, Söderholm J, McKay DM. (PubMed)
(237) Vitamin C derivative ascorbyl palmitate promotes ultraviolet-B-induced lipid peroxidation and cytotoxicity in keratinocytes by Meves A1, Stock SN, Beyerle A, Pittelkow MR, Peus D.(PubMed)
238. Effects of dried fish on antioxidant levels in rat liver by Anilakumar KR1, Khanum F, Krishna KR, Viswanathan KR. (PubMed)
(239) Vitamin A and retinoic acid in T cell-related immunity by Ross AC1.(PubMed)
(240) Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance by Cassani B1, Villablanca EJ, De Calisto J, Wang S, Mora JR.(PubMed)
(241) Modulatory role of vitamin A on the Candida albicans-induced immune response in human monocytes by Klassert TE1, Hanisch A, Bräuer J, Klaile E, Heyl KA, Mansour MK, Tam JM, Vyas JM, Slevogt H.(PubMed)
(242) [Toxicology of the synthetic antioxidants BHA and BHT in comparison with the natural antioxidant vitamin E].[Article in German]by Kahl R1, Kappus H.(PubMed)
(243) Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants by Darr D1, Dunston S, Faust H, Pinnell S.(PubMed)
(244) Immune dysfunction and cytokine production in hemodialysis. Could they be lessened by vitamin E-coated dialyzer membrane by Senatore M, Cecere P, Colombo P, Costantini L, Filiberti O, Piccini G, Peona C, Buemi M, Nicoletti A, Rizzuto G.(PubMed)
(245) Prospective crossover trial of the influence of vitamin E-coated dialyzer membranes on T-cell activation and cytokine induction by Girndt M1, Lengler S, Kaul H, Sester U, Sester M, Köhler H.(PubMed)
(246) Vitamin E and immunity by Moriguchi S1, Muraga M.(PubMed)
(247) The role of vitamin E in T-cell differentiation and the decrease of cellular immunity with aging.by Moriguchi S1.(PubMed)(249) By the way, doctor. I recently saw a TV ad for a product called "coralcalcium," which is supposed to prevent osteoporosis and other diseases. What do you know about it by Robb-Nicholson C.(PubMed)
(242) [Toxicology of the synthetic antioxidants BHA and BHT in comparison with the natural antioxidant vitamin E].[Article in German]by Kahl R1, Kappus H.(PubMed)
(243) Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants by Darr D1, Dunston S, Faust H, Pinnell S.(PubMed)
(244) Immune dysfunction and cytokine production in hemodialysis. Could they be lessened by vitamin E-coated dialyzer membrane by Senatore M, Cecere P, Colombo P, Costantini L, Filiberti O, Piccini G, Peona C, Buemi M, Nicoletti A, Rizzuto G.(PubMed)
(245) Prospective crossover trial of the influence of vitamin E-coated dialyzer membranes on T-cell activation and cytokine induction by Girndt M1, Lengler S, Kaul H, Sester U, Sester M, Köhler H.(PubMed)
(246) Vitamin E and immunity by Moriguchi S1, Muraga M.(PubMed)
(247) The role of vitamin E in T-cell differentiation and the decrease of cellular immunity with aging.by Moriguchi S1.(PubMed)(249) By the way, doctor. I recently saw a TV ad for a product called "coralcalcium," which is supposed to prevent osteoporosis and other diseases. What do you know about it by Robb-Nicholson C.(PubMed)
The Effects of #Antioxidant Enzymes on #Dementia (#LouGehrigsDisease), According to Studies
Kyle J. Norton
Dementia is a condition of neurodegeneration syndrome among elders, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgment. Over 47 million of the worldwide population are affected by the disease, mostly in the West.
The evaluation of diseases by holistic medicine has been lacking, especially through conventional medicine research and studies.
Maintaining a balanced ratio of antioxidants and free radicals is essential for our body to perform a daily physiological functions properly.
Truly, if our body is overwhelmed by overexpression of free radicals, it will be weakened by oxidative stress, causing adversely altered lipids, proteins, and DNA that can trigger a number of human diseases(a), including dementia.
* Free radicals are unstable molecules that contain at least an unpaired electron with function as oxidants or reductants by donating an electron to or accepting an electron from other molecules to exhibit chain and domino effects.
Most common oxygen-containing free radicals found epidemiologically in induced chronic diseases, include hydroxyl radical, superoxide anion radical, hydrogen peroxide, oxygen singlet, hypochlorite, nitric oxide radical, and peroxynitrite radical.
According to the University of Texas Medical Branch, observation of patients with amyotrophic lateral sclerosis (ALS) indicated that free radicals play a role in the expression of amyotrophic lateral sclerosis (ALS) through the alternation of \gene containing Cu,Zn superoxide dismutase (Cu,Zn-SOD).
Dr. Liu D said, "The selective degeneration of motor neurons in ALS may be caused by the high level of Cu, Zn-SOD present in and a large number of glutamatergic synapses projecting to these neurons"(b).
These selections of free radicals in the degeneration of motor neurons in ALS were attributed to free radical(mutation of Cu, Zn superoxide dismutase (Cu, Zn-SOD)) in long-term induction of oxidative stress, according to the study involved167 ALS patients (aged 59+/-13 years), treated or not with riluzole, compared with 62 age-matched healthy control subjects (aged 60+/-11 years) simultaneously, conducted by Hôpital de la Salpêtrière(c).
Some researchers suggested that cell damage and homeostatic disruption caused by free radicals can be inhibited by targeting free radicals of all kinds of molecules in the body(a), including lipids, nucleic acids, and proteins, through improving antioxidant status in the body.
* Antioxidant is a natural compound with function in inhibited molecules that cause oxidation before they can induce chains of domino reaction.
* Antioxidants include those produced by body tissue enzymes and external dietary antioxidants intake from functional food sources.
Here is the summary of "The Battles of Free Radicals, Antioxidant Enzymes, and Dementia (Lou Gehrig's Disease(Amyotrophic Lateral Sclerosis))"
Free radicals and Dementia (Lou Gehrig's disease)
Researchers found that glutamate in the synapses enhances the production of free radicals(77), due to its excitotoxicity, only in motor nerve cells but spares other nerve cells(74)(75) such as cells control senses and other body functions, causing disruption of astrocytes in regulated glutamate levels(76).
Antioxidants and Dementia (Lou Gehrig's disease)
1. Vitamin B12 (methylcobalamin)
High doses of vitamin B12 as an antioxidant have been shown to improve or slow muscle wasting in the later stages of patients with ALS disease(78)(79).
2. Vitamin E
Vitamin E protected cell membranes from lipid peroxidation damage(80) in reducing the risk of breakdown of the cell membrane caused by ALS(81).
3. Superoxide dismutase enzyme
Mutations in the superoxide dismutase enzyme can increase the risk of ALS(82) in catalyzing the dismutation of superoxide into oxygen and hydrogen peroxide(83).
$. Amino acids
A diet high in amino acids as antioxidants have shown some promising effect in treating ALS(86)(87).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra(PMC)
(b) The roles of free radicals in amyotrophic lateral sclerosis by Liu D(PubMed)
(c) Blood oxidative stress in amyotrophic lateral sclerosis by Bonnefont-Rousselot D1, Lacomblez L, Jaudon M, Lepage S, Salachas F, Bensimon G, Bizard C, Doppler V, Delattre J, Meininger V(PubMed)
(74) System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice by Mesci P1, Zaïdi S1, Lobsiger CS1, Millecamps S1, Escartin C2, Seilhean D1, Sato H3, Mallat M1, Boillée S4. (PubMed)
(75) Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: changes in arginase1 and inducible nitric oxide synthase by Lewis KE, Rasmussen AL, Bennett W, King A, West AK, Chung RS, Chuah MI1.(PubMed)
(76) Mutant disrupted-in-schizophrenia 1 in astrocytes: focus on glutamate metabolism by Abazyan S1, Yang EJ, Abazyan B, Xia M, Yang C, Rojas C, Slusher B, Sattler R, Pletnikov M.(PubMed)
(77) Glutamate release and free radical production following brain injury: effects of posttraumatic hypothermia by Globus MY1, Alonso O, Dietrich WD, Busto R, Ginsberg MD. (PubMed)
(78) Methyl Vitamin B12 but not methylfolate rescues a motor neuron-like cell line from homocysteine-mediated cell death. by Hemendinger RA1, Armstrong EJ 3rd, Brooks BR.(PubMed)
(79) [Clinical trials of ultra-high-dose methylcobalamin in ALS].[Article in Japanese] by Izumi Y1, Kaji R.(PubMed)
(80) Antioxidant effect of 4-nerolidylcatechol and α-tocopherol in erythrocyte ghost membranes and phospholipid bilayers. by Fernandes KS1, Silva AH, Mendanha SA, Rezende KR, Alonso A.(PubMed)
(81) Vitamin E serum levels and controlled supplementation and risk of amyotrophic lateral sclerosis by Michal Freedman D1, Kuncl RW, Weinstein SJ, Malila N, Virtamo J, Albanes D.(PubMed)
(82) Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes by Pratt AJ1, Shin DS1, Merz GE2, Rambo RP3, Lancaster WA4, Dyer KN3, Borbat PP5, Poole FL 2nd4, Adams MW4, Freed JH5, Crane BR2, Tainer JA6, Getzoff ED7. (PubMed)
(83) Hydrogen peroxide induces modifications of human extracellular superoxide dismutase that results in enzyme inhibition by Gottfredsen RH1, Larsen UG, Enghild JJ, Petersen SV. (PubMed)
(84) Oxidative DNA damage and alteration of glutamate transporter expressions in the hippocampal Ca1 area immediately after ischemic insult. by An SJ1, Kang TC, Park SK, Hwang IK, Cho SS, Chung MH, Won MH. (PubMed)
(85) Functional contribution of the transcription factor ATF4 to the pathogenesis of amyotrophic lateral sclerosis.by Matus S1, Lopez E, Valenzuela V, Nassif M, Hetz C.(PubMed)
(86) Amino acids as biomarkers in the SOD1(G93A) mouse model of ALS.by Bame M1, Grier RE, Needleman R, Brusilow WS. (PubMed)
(87) Branched-chain amino acids and amyotrophic lateral sclerosis: a treatment failure? The Italian ALS Study Group.[No authors listed](PubMed)
Dementia is a condition of neurodegeneration syndrome among elders, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgment. Over 47 million of the worldwide population are affected by the disease, mostly in the West.
The evaluation of diseases by holistic medicine has been lacking, especially through conventional medicine research and studies.
Maintaining a balanced ratio of antioxidants and free radicals is essential for our body to perform a daily physiological functions properly.
Truly, if our body is overwhelmed by overexpression of free radicals, it will be weakened by oxidative stress, causing adversely altered lipids, proteins, and DNA that can trigger a number of human diseases(a), including dementia.
* Free radicals are unstable molecules that contain at least an unpaired electron with function as oxidants or reductants by donating an electron to or accepting an electron from other molecules to exhibit chain and domino effects.
Most common oxygen-containing free radicals found epidemiologically in induced chronic diseases, include hydroxyl radical, superoxide anion radical, hydrogen peroxide, oxygen singlet, hypochlorite, nitric oxide radical, and peroxynitrite radical.
According to the University of Texas Medical Branch, observation of patients with amyotrophic lateral sclerosis (ALS) indicated that free radicals play a role in the expression of amyotrophic lateral sclerosis (ALS) through the alternation of \gene containing Cu,Zn superoxide dismutase (Cu,Zn-SOD).
Dr. Liu D said, "The selective degeneration of motor neurons in ALS may be caused by the high level of Cu, Zn-SOD present in and a large number of glutamatergic synapses projecting to these neurons"(b).
These selections of free radicals in the degeneration of motor neurons in ALS were attributed to free radical(mutation of Cu, Zn superoxide dismutase (Cu, Zn-SOD)) in long-term induction of oxidative stress, according to the study involved167 ALS patients (aged 59+/-13 years), treated or not with riluzole, compared with 62 age-matched healthy control subjects (aged 60+/-11 years) simultaneously, conducted by Hôpital de la Salpêtrière(c).
Some researchers suggested that cell damage and homeostatic disruption caused by free radicals can be inhibited by targeting free radicals of all kinds of molecules in the body(a), including lipids, nucleic acids, and proteins, through improving antioxidant status in the body.
* Antioxidant is a natural compound with function in inhibited molecules that cause oxidation before they can induce chains of domino reaction.
* Antioxidants include those produced by body tissue enzymes and external dietary antioxidants intake from functional food sources.
Here is the summary of "The Battles of Free Radicals, Antioxidant Enzymes, and Dementia (Lou Gehrig's Disease(Amyotrophic Lateral Sclerosis))"
Free radicals and Dementia (Lou Gehrig's disease)
Researchers found that glutamate in the synapses enhances the production of free radicals(77), due to its excitotoxicity, only in motor nerve cells but spares other nerve cells(74)(75) such as cells control senses and other body functions, causing disruption of astrocytes in regulated glutamate levels(76).
Antioxidants and Dementia (Lou Gehrig's disease)
1. Vitamin B12 (methylcobalamin)
High doses of vitamin B12 as an antioxidant have been shown to improve or slow muscle wasting in the later stages of patients with ALS disease(78)(79).
2. Vitamin E
Vitamin E protected cell membranes from lipid peroxidation damage(80) in reducing the risk of breakdown of the cell membrane caused by ALS(81).
3. Superoxide dismutase enzyme
Mutations in the superoxide dismutase enzyme can increase the risk of ALS(82) in catalyzing the dismutation of superoxide into oxygen and hydrogen peroxide(83).
$. Amino acids
A diet high in amino acids as antioxidants have shown some promising effect in treating ALS(86)(87).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra(PMC)
(b) The roles of free radicals in amyotrophic lateral sclerosis by Liu D(PubMed)
(c) Blood oxidative stress in amyotrophic lateral sclerosis by Bonnefont-Rousselot D1, Lacomblez L, Jaudon M, Lepage S, Salachas F, Bensimon G, Bizard C, Doppler V, Delattre J, Meininger V(PubMed)
(74) System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice by Mesci P1, Zaïdi S1, Lobsiger CS1, Millecamps S1, Escartin C2, Seilhean D1, Sato H3, Mallat M1, Boillée S4. (PubMed)
(75) Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: changes in arginase1 and inducible nitric oxide synthase by Lewis KE, Rasmussen AL, Bennett W, King A, West AK, Chung RS, Chuah MI1.(PubMed)
(76) Mutant disrupted-in-schizophrenia 1 in astrocytes: focus on glutamate metabolism by Abazyan S1, Yang EJ, Abazyan B, Xia M, Yang C, Rojas C, Slusher B, Sattler R, Pletnikov M.(PubMed)
(77) Glutamate release and free radical production following brain injury: effects of posttraumatic hypothermia by Globus MY1, Alonso O, Dietrich WD, Busto R, Ginsberg MD. (PubMed)
(78) Methyl Vitamin B12 but not methylfolate rescues a motor neuron-like cell line from homocysteine-mediated cell death. by Hemendinger RA1, Armstrong EJ 3rd, Brooks BR.(PubMed)
(79) [Clinical trials of ultra-high-dose methylcobalamin in ALS].[Article in Japanese] by Izumi Y1, Kaji R.(PubMed)
(80) Antioxidant effect of 4-nerolidylcatechol and α-tocopherol in erythrocyte ghost membranes and phospholipid bilayers. by Fernandes KS1, Silva AH, Mendanha SA, Rezende KR, Alonso A.(PubMed)
(81) Vitamin E serum levels and controlled supplementation and risk of amyotrophic lateral sclerosis by Michal Freedman D1, Kuncl RW, Weinstein SJ, Malila N, Virtamo J, Albanes D.(PubMed)
(82) Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes by Pratt AJ1, Shin DS1, Merz GE2, Rambo RP3, Lancaster WA4, Dyer KN3, Borbat PP5, Poole FL 2nd4, Adams MW4, Freed JH5, Crane BR2, Tainer JA6, Getzoff ED7. (PubMed)
(83) Hydrogen peroxide induces modifications of human extracellular superoxide dismutase that results in enzyme inhibition by Gottfredsen RH1, Larsen UG, Enghild JJ, Petersen SV. (PubMed)
(84) Oxidative DNA damage and alteration of glutamate transporter expressions in the hippocampal Ca1 area immediately after ischemic insult. by An SJ1, Kang TC, Park SK, Hwang IK, Cho SS, Chung MH, Won MH. (PubMed)
(85) Functional contribution of the transcription factor ATF4 to the pathogenesis of amyotrophic lateral sclerosis.by Matus S1, Lopez E, Valenzuela V, Nassif M, Hetz C.(PubMed)
(86) Amino acids as biomarkers in the SOD1(G93A) mouse model of ALS.by Bame M1, Grier RE, Needleman R, Brusilow WS. (PubMed)
(87) Branched-chain amino acids and amyotrophic lateral sclerosis: a treatment failure? The Italian ALS Study Group.[No authors listed](PubMed)
#Greentea Inhibtts Allergic Inflammatory Diseases by Suppressing the Proteins Associated with Inflammatory Response, Scientists Say
Kyle J. Norton
Green tea may have a particular and special effect in ameliorating autoimmunity in the precipitation of allergic diseases, some scientists opinionated.
Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world.
Allergic diseases are a class of conditions characterized by an overreaction of the immune system to substances that cause little or no harm to the body.
Investigation of the effect of green tea bioactive compounds in reduced abnormal immune allergic expression was found to associate with certain mechanisms.
According to the statistic, approximately 60 million Americans suffer from allergic diseases. affecting all age groups.
The most common allergic diseases include hay fever, food allergy, and respiratory diseases such as asthma and eczema.
In a rare case, allergies can trigger also life-threatening anaphylaxis.
The most common symptoms include itch, redden, Hives Itchy skin Rash Facial swelling Wheezing, sneezing Itching of the nose, eyes, or roof of the mouth, runny and stuffy nose....and swelling of the lips, tongue, face, or throat.
However, if you experience some severe symptoms of a drop in blood pressure, any form of shortness of breath, skin rash, lightheadedness, .... and a rapid, weak pulse, you may already be infected by life-threatening anaphylaxis, please visit the nearest hospital right the way.
According to Kyushu University, Epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me) isolated from cv. "Benifuuki" green tea expressed strong and positive activities in inhibiting the mast cell production in precipitated allergic inflammatory responses and suppressed the high-affinity IgE receptor (FcεRI) function in the expression of immunoglobulin E (IgE), an antibody isotype involved in allergy disorder through 67 kDa laminin receptor in the mediation of the suppressive effect by epigallocatechin-3-O-gallate.
Further analysis also found that the bioactive compound binds to 67 kDa laminin receptor to attenuate allergic expression induced by mast cells by suppressing the myosin light chain phosphorylation in the regulated immune response to eosinophil (a type of disease-fighting white blood cell) migration in the tissue, a characteristic feature of allergic diseases and ERK1/2 phosphorylation signaling by modulation of inflammatory cytokines expression.
In a double-blind clinical study of the green tea effect on subjects exposed to Japanese cedar pollinosis, administration of Benifuuki green tea containing O-methylated catechins showed significantly relieved allergic symptoms induced by pollen such as nose blowing, and eye itching in compared with the placebo group without affecting the normal immune responses.
More interestingly, in mouse bone marrow-derived mast cells activated by antigens, the bioactive compound epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3″Me) in combination with ginger extract also demonstrated a strongly anti-delay-type allergic effect by suppressing cytokines secretion of tumor necrosis factor (TNF-α), a cell signaling protein (cytokine) in response to systemic inflammation in the acute phase infection. and macrophage Inflammatory Proteins(MIP-1α), a chemokine-involved host response to invading bacteria and viruses.
Compared to the dose of 5.1 times higher in EGCG, injection of 8.5 mg of EGCG3″Me exhibited much stronger anti-allergic activity than 43.5 mg of EGCG, observed by the area under the curve AUC (area under the drug concentration-time curve; min μg/ml) of 6.72 ± 2.87 in EGCG and 8.48 ± 2.54 in EGCG3″Me.
Taken together, green tea with abundantly bioactive Epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me) may be considered a functional food for protection against autoimmune response stimulated by unharmful allergens.
However, further data collection on studies performed with human consumption during the course of the disease will be necessary to complete the picture of its antiallergic possibilities.
Intake of green tea extracts, such as EGCG should be taken with extreme care, as overdoses induced acute liver toxicity have been reported by some medical literature.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(*) Anti-Allergic Action of O-methylated EGCG in Green Tea Cultivar Benifuuki by MARI MAEDA-YAMAMOTO1 * AND HIROFUMI TACHIBANA2(Journal of Food and Drug Analysis, Vol. 20, Suppl. 1, 2012, Pages 313-317)
(1) Human clinical studies of tea polyphenols in allergy or lifestyle-related diseases by Maeda-Yamamoto M1. (PubMed)
(2) In vitro and in vivo anti-allergic effects of ‘benifuuki’ green tea containing O-methylated catechin and ginger extract enhancement by Mari Maeda-Yamamoto,
1 Kaori Ema,1 and Ikuo Shibuichi2(PubMed)
Green tea may have a particular and special effect in ameliorating autoimmunity in the precipitation of allergic diseases, some scientists opinionated.
Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world.
Allergic diseases are a class of conditions characterized by an overreaction of the immune system to substances that cause little or no harm to the body.
Investigation of the effect of green tea bioactive compounds in reduced abnormal immune allergic expression was found to associate with certain mechanisms.
According to the statistic, approximately 60 million Americans suffer from allergic diseases. affecting all age groups.
The most common allergic diseases include hay fever, food allergy, and respiratory diseases such as asthma and eczema.
In a rare case, allergies can trigger also life-threatening anaphylaxis.
The most common symptoms include itch, redden, Hives Itchy skin Rash Facial swelling Wheezing, sneezing Itching of the nose, eyes, or roof of the mouth, runny and stuffy nose....and swelling of the lips, tongue, face, or throat.
However, if you experience some severe symptoms of a drop in blood pressure, any form of shortness of breath, skin rash, lightheadedness, .... and a rapid, weak pulse, you may already be infected by life-threatening anaphylaxis, please visit the nearest hospital right the way.
According to Kyushu University, Epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me) isolated from cv. "Benifuuki" green tea expressed strong and positive activities in inhibiting the mast cell production in precipitated allergic inflammatory responses and suppressed the high-affinity IgE receptor (FcεRI) function in the expression of immunoglobulin E (IgE), an antibody isotype involved in allergy disorder through 67 kDa laminin receptor in the mediation of the suppressive effect by epigallocatechin-3-O-gallate.
Further analysis also found that the bioactive compound binds to 67 kDa laminin receptor to attenuate allergic expression induced by mast cells by suppressing the myosin light chain phosphorylation in the regulated immune response to eosinophil (a type of disease-fighting white blood cell) migration in the tissue, a characteristic feature of allergic diseases and ERK1/2 phosphorylation signaling by modulation of inflammatory cytokines expression.
In a double-blind clinical study of the green tea effect on subjects exposed to Japanese cedar pollinosis, administration of Benifuuki green tea containing O-methylated catechins showed significantly relieved allergic symptoms induced by pollen such as nose blowing, and eye itching in compared with the placebo group without affecting the normal immune responses.
More interestingly, in mouse bone marrow-derived mast cells activated by antigens, the bioactive compound epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3″Me) in combination with ginger extract also demonstrated a strongly anti-delay-type allergic effect by suppressing cytokines secretion of tumor necrosis factor (TNF-α), a cell signaling protein (cytokine) in response to systemic inflammation in the acute phase infection. and macrophage Inflammatory Proteins(MIP-1α), a chemokine-involved host response to invading bacteria and viruses.
Compared to the dose of 5.1 times higher in EGCG, injection of 8.5 mg of EGCG3″Me exhibited much stronger anti-allergic activity than 43.5 mg of EGCG, observed by the area under the curve AUC (area under the drug concentration-time curve; min μg/ml) of 6.72 ± 2.87 in EGCG and 8.48 ± 2.54 in EGCG3″Me.
Taken together, green tea with abundantly bioactive Epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me) may be considered a functional food for protection against autoimmune response stimulated by unharmful allergens.
However, further data collection on studies performed with human consumption during the course of the disease will be necessary to complete the picture of its antiallergic possibilities.
Intake of green tea extracts, such as EGCG should be taken with extreme care, as overdoses induced acute liver toxicity have been reported by some medical literature.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(*) Anti-Allergic Action of O-methylated EGCG in Green Tea Cultivar Benifuuki by MARI MAEDA-YAMAMOTO1 * AND HIROFUMI TACHIBANA2(Journal of Food and Drug Analysis, Vol. 20, Suppl. 1, 2012, Pages 313-317)
(1) Human clinical studies of tea polyphenols in allergy or lifestyle-related diseases by Maeda-Yamamoto M1. (PubMed)
(2) In vitro and in vivo anti-allergic effects of ‘benifuuki’ green tea containing O-methylated catechin and ginger extract enhancement by Mari Maeda-Yamamoto,
1 Kaori Ema,1 and Ikuo Shibuichi2(PubMed)#Healthyfood #Kidneybeans Process Anti Chronic Diseases Activities by Attenuating the increased Glycaemic Stress, Researchers Suggest
Kyle J. Norton
A recent study suggested a regular intake of kidney bean may have a potential effect in the prevention and treatment of chronic diseases.
Chronic diseases are medical conditions that last more than 3 months or more and can not be cured.
According to WHO in the article of "Noncommunicable Diseases" suggested, "The four main types of noncommunicable diseases are cardiovascular diseases (like heart attacks and stroke), cancers, chronic respiratory diseases (such as chronic obstructed pulmonary disease and asthma) and diabetes"(4).
Some chronic conditions also are correlated with other diseases, such as chronic conditions of high blood cholesterol and pressure are associated to increase the risk of heart attack and stroke.
According to the Center for diseases control and Prevention statistic, approximately, over 117 million people worldwide had one or more chronic health conditions. And 1 in 4 adults had two or more chronic health conditions(5).
The chronic diseases are the 7th most common causes of death in 2014(5).
Although most common causes of the chronic condition are either debatable or depending to types of condition. However, some researchers suggested that physical activity, poor nutrition, tobacco use, and excessive alcohol drinking are the most common risk factors.
Chronic diseases today have become a burden of the healthcare system, according to CDC. In US, the conditions cost over 68% of annual healthcare expenditures of $2.7 trillion(5).
Depending on type of chronic condition, patients may experience some correlated symptoms
* In Patients with cardiovascular diseases, the symptoms include chest pain, chest tightness, chest pressure and chest discomfort (angina),....and shortness of breath.
* Depending on the type of cancer, symptoms may include blood in the urine, hoarseness, persistent lumps or swollen glands. ... and indigestion or difficulty swallowing.
* Patients with chronic respiratory diseases may experience shortness of breath, especially during physical activities, wheezing,... and chest tightness.
* Patients with diabetes may include symptoms of unusual thirst, frequent urination, weight change,........ and extreme fatigue or lack of energy.
Kidney bean is very popular because of its kidney shape, strong flavor, and color of reddish brown in nature. The bean often is an excellent dietary selection with no cholesterol, but a good source of protein and minerals.
According to the University of Colorado Colorado Springs, consumption of kidney bean regularly attenuated the increased glycaemic stress (hyperglycemia and hyperinsulinemia) including diabetes, CVD and cancer.
Dr. Hutchins AM, the lead author said, " (The efficacy of kidney in reduced risk of chronic illness may be attributed to the) glycaemic response and the impact that relationship may have on the risk of developing diabetes, CVD and cancer".
In the study to compared two different illumination conditions during germination (12 h light/12 h dark vs 24 h dark) in lentils (Lensculinaris L.) and kidney beans (Phaseolus vulgaris L.), melatonin content exerted a significantly antioxidant activity in protection against free radicals as well as showing the use of food as preventive strategies in combating chronic diseases through the diet.
Furthermore, the investigation of phenolic-rich extracts obtained from two kinds of common beans, white kidney beans (WKB) and round purple beans (RPB), extracts Phenolic acids and phenolic compounds expressed strong antioxidants and anti-inflammatory activities in reduced the incidence of several chronic diseases that share an inflammatory component.
Dr. García-Lafuente A, the lead researcher in the study said, "common bean extracts may be used as a source of anti-inflammatory agents as well as a dietary complement for health promotion".
Taking together, intake kidney beans regularly may reduce risk and progression of chronic illness through the immunomodulatory effects involved increased antioxidant and ameliorated inflammatory activities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phaseolus beans: impact on glycaemic response and chronic disease risk in human subjects by Hutchins AM1, Winham DM, Thompson SV. (PubMed)
(2) Effect of illumination on the content of melatonin, phenolic compounds, and antioxidant activity during germination of lentils (Lens culinaris L.) and kidney beans (Phaseolus vulgaris L.) by Aguilera Y1, Liébana R, Herrera T, Rebollo-Hernanz M, Sanchez-Puelles C, Benítez V, Martín-Cabrejas MA. (PubMed)
(3) In vitro anti-inflammatory activity of phenolic rich extracts from white and red common beans by García-Lafuente A1, Moro C2, Manchón N2, Gonzalo-Ruiz A3, Villares A2, Guillamón E2, Rostagno M2, Mateo-Vivaracho L2. (PubMed)
(4) Noncommunicable diseases by WHO
(5) Chronic Diseases: The Leading Causes of Death and Disability in the United States(CDC)
A recent study suggested a regular intake of kidney bean may have a potential effect in the prevention and treatment of chronic diseases.
Chronic diseases are medical conditions that last more than 3 months or more and can not be cured.
According to WHO in the article of "Noncommunicable Diseases" suggested, "The four main types of noncommunicable diseases are cardiovascular diseases (like heart attacks and stroke), cancers, chronic respiratory diseases (such as chronic obstructed pulmonary disease and asthma) and diabetes"(4).
Some chronic conditions also are correlated with other diseases, such as chronic conditions of high blood cholesterol and pressure are associated to increase the risk of heart attack and stroke.
According to the Center for diseases control and Prevention statistic, approximately, over 117 million people worldwide had one or more chronic health conditions. And 1 in 4 adults had two or more chronic health conditions(5).
The chronic diseases are the 7th most common causes of death in 2014(5).
Although most common causes of the chronic condition are either debatable or depending to types of condition. However, some researchers suggested that physical activity, poor nutrition, tobacco use, and excessive alcohol drinking are the most common risk factors.
Chronic diseases today have become a burden of the healthcare system, according to CDC. In US, the conditions cost over 68% of annual healthcare expenditures of $2.7 trillion(5).
Depending on type of chronic condition, patients may experience some correlated symptoms
* In Patients with cardiovascular diseases, the symptoms include chest pain, chest tightness, chest pressure and chest discomfort (angina),....and shortness of breath.
* Depending on the type of cancer, symptoms may include blood in the urine, hoarseness, persistent lumps or swollen glands. ... and indigestion or difficulty swallowing.
* Patients with chronic respiratory diseases may experience shortness of breath, especially during physical activities, wheezing,... and chest tightness.
* Patients with diabetes may include symptoms of unusual thirst, frequent urination, weight change,........ and extreme fatigue or lack of energy.
Kidney bean is very popular because of its kidney shape, strong flavor, and color of reddish brown in nature. The bean often is an excellent dietary selection with no cholesterol, but a good source of protein and minerals.
According to the University of Colorado Colorado Springs, consumption of kidney bean regularly attenuated the increased glycaemic stress (hyperglycemia and hyperinsulinemia) including diabetes, CVD and cancer.
Dr. Hutchins AM, the lead author said, " (The efficacy of kidney in reduced risk of chronic illness may be attributed to the) glycaemic response and the impact that relationship may have on the risk of developing diabetes, CVD and cancer".
In the study to compared two different illumination conditions during germination (12 h light/12 h dark vs 24 h dark) in lentils (Lensculinaris L.) and kidney beans (Phaseolus vulgaris L.), melatonin content exerted a significantly antioxidant activity in protection against free radicals as well as showing the use of food as preventive strategies in combating chronic diseases through the diet.
Furthermore, the investigation of phenolic-rich extracts obtained from two kinds of common beans, white kidney beans (WKB) and round purple beans (RPB), extracts Phenolic acids and phenolic compounds expressed strong antioxidants and anti-inflammatory activities in reduced the incidence of several chronic diseases that share an inflammatory component.
Dr. García-Lafuente A, the lead researcher in the study said, "common bean extracts may be used as a source of anti-inflammatory agents as well as a dietary complement for health promotion".
Taking together, intake kidney beans regularly may reduce risk and progression of chronic illness through the immunomodulatory effects involved increased antioxidant and ameliorated inflammatory activities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phaseolus beans: impact on glycaemic response and chronic disease risk in human subjects by Hutchins AM1, Winham DM, Thompson SV. (PubMed)
(2) Effect of illumination on the content of melatonin, phenolic compounds, and antioxidant activity during germination of lentils (Lens culinaris L.) and kidney beans (Phaseolus vulgaris L.) by Aguilera Y1, Liébana R, Herrera T, Rebollo-Hernanz M, Sanchez-Puelles C, Benítez V, Martín-Cabrejas MA. (PubMed)
(3) In vitro anti-inflammatory activity of phenolic rich extracts from white and red common beans by García-Lafuente A1, Moro C2, Manchón N2, Gonzalo-Ruiz A3, Villares A2, Guillamón E2, Rostagno M2, Mateo-Vivaracho L2. (PubMed)
(4) Noncommunicable diseases by WHO
(5) Chronic Diseases: The Leading Causes of Death and Disability in the United States(CDC)
#Healthyfoods That Treat Migraine Headaches, According to Studies
Kyle J. Norton
A migraine is one most common headaches characterized by a chronic neurological disorder of moderate to severe headaches, and nausea that usually develops gradually over 5–20 minutes and lasts for less than 60 minutes.
The condition affects over 15% population in the US, as a result of the change in the brain and its surrounding blood vessels.
Some researchers suggested that dietary and gastrointestinal issues have a significant impact on the clinical expression of a migraine, including gut dysfunction during and between attacks, food triggers, increase in migraine with obesity, comorbid GI and systemic inflammation influenced by diet, and specific food allergies such as dairy and gluten(1).
And, caregivers and practitioners not only need to encourage migraineurs to seek consistency in their lifestyle behaviors, and environmental exposures, as a way of avoiding sudden changes that may precipitate attacks(1) but also must remind them to avoid suspected foods that trigger, consistently(1).
Believe it or not, according to statistics and research, migraine headaches have caused a substantial individual impact on work productivity and increased a significant societal burden to direct medical costs and lost work time(2).
And in more severe persistent migraine, the lost work time costs greatly exceed medical care costs(2).
The most common symptoms during migraine attacks include pain on one side or both sides of the head and pain that feels throbbing or pulsing.
Some patients during attacks also experience symptoms of light, sounds, smells, and touch sensitivity.
In some cases, the attack also induces symptoms of nausea and vomiting. blurred vision..... and lightheadedness.
Wholefoods for a Migraine headache
Certain diets may trigger the attack of a migraine due to an allergic reaction in certain people, but the below-suggested foods may be helpful to people who experience migraine with no allergic effects.
1. Water
Water, an essential for the body’s proper functioning, and dehydration may trigger the migraine attack.
In a study of 50 migraineurs who were asked if insufficient fluid intake could provoke their migraine attacks conducted by The City of London Migraine Clinic, researchers found that twenty replied "yes," 7 were doubtfully positive, and 23 said "no."
In addition 14 of 45 migraineurs at a meeting of the British Migraine Association (UK) also recognized fluid deprivation as one of their migraine triggers. (E.C.1).
Therefore, adding fluid deprivation to migraine patients may reduce the number of migraine attacks.
2. Fish oil
Omega-3 PUFA, from fish oil-eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) process anti-inflammatory properties which are useful in the management of inflammatory and autoimmune diseases, including rheumatoid arthritis, Crohn's disease, ulcerative colitis, psoriasis, lupus erythematosus, multiple sclerosis, and migraine headaches. (E.C.2)
3. Broccoli
Broccoli is a very good source of magnesium and a good source of calcium.
Magnesium plays an essential in many intracellular processes and in migraine pathogenesis. Low levels of magnesium may promote cortical spreading depression, hyper-aggregation of platelets, affect serotonin receptor function, and influence synthesis and release of a variety of neurotransmitters which can trigger a migraine headache(B.A.8)
4. Sardines
Sardines contain a measurable amount of Omega 3 fatty acid, calcium, and CoQ10 with function in reduced frequency of a migraine headache (E.B.3)(E.B.2)
5. Spinach
Spinach is an excellent source of both calcium, magnesium, and vitamin B2 (riboflavin).
Riboflavin therapy supplemented may be an appropriate alternative in patients with migraine disorder as it significantly decreases headache frequency, intensity, duration, and medication intake (E.C.7)
6. Mustard Greens
The World's Healthiest Foods recommends mustard greens as an excellent source of calcium and a very good source of magnesium which is important in preventing and treating migraine headaches (See E.B.1 and 2)
7. Fish
Besides being rich in Omega 3 fatty acids, all fish contain more or less DL-phenylalanine, an essential amino acid that is important for our body converts phenylalanine to tyrosine, another amino acid then to epinephrine and norepinephrine, which are important brain chemicals called neurotransmitters.
Some researchers suggest that DL-phenylalanine(DLPA) appears to potentiate pain relief and ease depression in patients receiving opiates for chronic non-malignant pain(E.C.9).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(E.C.1) http://www.ncbi.nlm.nih.gov/pubmed/15953311
(E.C.2) http://www.ncbi.nlm.nih.gov/pubmed/12480795
(E.C.7) http://www.ncbi.nlm.nih.gov/pubmed/21197315
(E.C.9) http://www.ncbi.nlm.nih.gov/pubmed/10998643
(B.A.8) http://www.ncbi.nlm.nih.gov/pubmed/22426836
(E.B.2) http://www.ncbi.nlm.nih.gov/pubmed/2948651
(E.B.3) http://www.ncbi.nlm.nih.gov/pubmed/17355497
(1) https://www.ncbi.nlm.nih.gov/pubmed/24068338
(2) https://www.ncbi.nlm.nih.gov/pubmed/26563803
A migraine is one most common headaches characterized by a chronic neurological disorder of moderate to severe headaches, and nausea that usually develops gradually over 5–20 minutes and lasts for less than 60 minutes.
The condition affects over 15% population in the US, as a result of the change in the brain and its surrounding blood vessels.
Some researchers suggested that dietary and gastrointestinal issues have a significant impact on the clinical expression of a migraine, including gut dysfunction during and between attacks, food triggers, increase in migraine with obesity, comorbid GI and systemic inflammation influenced by diet, and specific food allergies such as dairy and gluten(1).
And, caregivers and practitioners not only need to encourage migraineurs to seek consistency in their lifestyle behaviors, and environmental exposures, as a way of avoiding sudden changes that may precipitate attacks(1) but also must remind them to avoid suspected foods that trigger, consistently(1).
Believe it or not, according to statistics and research, migraine headaches have caused a substantial individual impact on work productivity and increased a significant societal burden to direct medical costs and lost work time(2).
And in more severe persistent migraine, the lost work time costs greatly exceed medical care costs(2).
The most common symptoms during migraine attacks include pain on one side or both sides of the head and pain that feels throbbing or pulsing.
Some patients during attacks also experience symptoms of light, sounds, smells, and touch sensitivity.
In some cases, the attack also induces symptoms of nausea and vomiting. blurred vision..... and lightheadedness.
Wholefoods for a Migraine headache
Certain diets may trigger the attack of a migraine due to an allergic reaction in certain people, but the below-suggested foods may be helpful to people who experience migraine with no allergic effects.
1. Water
Water, an essential for the body’s proper functioning, and dehydration may trigger the migraine attack.
In a study of 50 migraineurs who were asked if insufficient fluid intake could provoke their migraine attacks conducted by The City of London Migraine Clinic, researchers found that twenty replied "yes," 7 were doubtfully positive, and 23 said "no."
In addition 14 of 45 migraineurs at a meeting of the British Migraine Association (UK) also recognized fluid deprivation as one of their migraine triggers. (E.C.1).
Therefore, adding fluid deprivation to migraine patients may reduce the number of migraine attacks.
2. Fish oil
Omega-3 PUFA, from fish oil-eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) process anti-inflammatory properties which are useful in the management of inflammatory and autoimmune diseases, including rheumatoid arthritis, Crohn's disease, ulcerative colitis, psoriasis, lupus erythematosus, multiple sclerosis, and migraine headaches. (E.C.2)
3. Broccoli
Broccoli is a very good source of magnesium and a good source of calcium.
Magnesium plays an essential in many intracellular processes and in migraine pathogenesis. Low levels of magnesium may promote cortical spreading depression, hyper-aggregation of platelets, affect serotonin receptor function, and influence synthesis and release of a variety of neurotransmitters which can trigger a migraine headache(B.A.8)
4. Sardines
Sardines contain a measurable amount of Omega 3 fatty acid, calcium, and CoQ10 with function in reduced frequency of a migraine headache (E.B.3)(E.B.2)
5. Spinach
Spinach is an excellent source of both calcium, magnesium, and vitamin B2 (riboflavin).
Riboflavin therapy supplemented may be an appropriate alternative in patients with migraine disorder as it significantly decreases headache frequency, intensity, duration, and medication intake (E.C.7)
6. Mustard Greens
The World's Healthiest Foods recommends mustard greens as an excellent source of calcium and a very good source of magnesium which is important in preventing and treating migraine headaches (See E.B.1 and 2)
7. Fish
Besides being rich in Omega 3 fatty acids, all fish contain more or less DL-phenylalanine, an essential amino acid that is important for our body converts phenylalanine to tyrosine, another amino acid then to epinephrine and norepinephrine, which are important brain chemicals called neurotransmitters.
Some researchers suggest that DL-phenylalanine(DLPA) appears to potentiate pain relief and ease depression in patients receiving opiates for chronic non-malignant pain(E.C.9).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(E.C.1) http://www.ncbi.nlm.nih.gov/pubmed/15953311
(E.C.2) http://www.ncbi.nlm.nih.gov/pubmed/12480795
(E.C.7) http://www.ncbi.nlm.nih.gov/pubmed/21197315
(E.C.9) http://www.ncbi.nlm.nih.gov/pubmed/10998643
(B.A.8) http://www.ncbi.nlm.nih.gov/pubmed/22426836
(E.B.2) http://www.ncbi.nlm.nih.gov/pubmed/2948651
(E.B.3) http://www.ncbi.nlm.nih.gov/pubmed/17355497
(1) https://www.ncbi.nlm.nih.gov/pubmed/24068338
(2) https://www.ncbi.nlm.nih.gov/pubmed/26563803
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