#CaffeinatedCoffee Normalizes the Levels of Sex Hormones #Androgen and #Estrogen Depending on the Body's Needs

Kyle J. Norton

Coffee, a popular and social beverage, is a drink made from roasted beans from the Coffea plant, native to tropical Africa and Madagascar.

A recent study suggested that coffee may have a direct effect on the influence of sex hormone steroid-binding globulin(SSBG) in the stimulated production of estrogen and androgen depending on levels in the host.

Sex hormones are a class of hormones, affecting sexual development and reproduction. Steroid-binding globulin(SSBG), is a sex hormone, having a direct effect on androgen and estrogen.

In sex hormones and sexual differentiation, the most influential hormone in human sexual desire is testosterone.

Low levels of estrogen in women can also reduce sex drive caused by vaginal dryness that can lead to painful intercourse

Mentally, women with low levels of estrogen also experience unstable mood and sleep patterns that can have a strong impact on sexual desire.

However, sexual motivation is influenced by a set of hormones, including testosterone, estrogen, progesterone, oxytocin, and vasopressin...... Altogether, they control the ability to engage in sexual behaviors.

The actual causes of abnormal levels of sex hormones are debatable. But all researchers agree that aging plays an important role in the production of the sex hormone steroid-binding globulin(SSBG).


Diseases, also the risk factors associated with abnormal levels of serum of SHBG concentrations include obesity, insulin resistance, type 2 diabetes hypothyroidism, Cushing syndrome, nonalcoholic fatty liver disease, hypertension, ....... and androgen steroid use

The normal ranges for serum of SHBG concentrations in adults are:
* Males: 10 to 57 nanomoles per liter (nmol/L)
*Females (nonpregnant): 18 to 144 nmol/L

In an 8-week parallel-arm randomized controlled trial with Healthy adults (n = 42) recruited from the Boston community, including regular coffee consumers, nonsmokers, and overweight, randomized to five 6-ounce cups of caffeinated or decaffeinated instant coffee or water per day, at 4 weeks, researchers surprisingly found that
* Decaffeinated coffee drinking was associated with borderline significantly increased levels of SHBG in women, but not in men.

*. At week 4, decaffeinated coffee decreased total and free testosterone and caffeinated coffee decreased only total testosterone in women.

*. In contrast to women participants, men's consumption of caffeinated coffee displayed a significantly increased total testosterone and decreased total and free estradiol hormones.

*. The study also indicated that caffeinated coffee consumption does not exert any effect on SHBG in either men or women.

These results suggested that the intake of coffee may have a strong impact in maintained normal levels of SHBG, thus reducing the risk of low levels of SHBG-induced higher testosterone levels in overweight women, causing androgenization and development of polycystic ovarian syndrome.

And in men, normal levels of testosterone may also have a significant contribution to healthy libido, building muscle mass, and maintaining energy levels.

Some researchers suggested that increased testosterone levels for middle-aged (30 to 50 years old) and older males may also improve physical energy, strength, stamina, and mental aggressiveness which were lost in the aging population.

In contrast to the above differentiation, in type 2 diabetic patients, coffee and coffee caffeine showed an elevated effect as a mediator of sex hormone-binding globulin in both androgen and estrogen, particularly in women compared to healthy young adults.

Dr. Eric L. Ding and colleagues in the study to evaluate "Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Women and Men" said, " Among women, higher plasma levels of sex hormone–binding globulin were prospectively associated with a lower risk of type 2 diabetes and " the predicted odds ratio of type 2 diabetes per standard-deviation increase in the plasma level of sex hormone–binding globulin was 0.28 (95% CI, 0.13 to 0.58) among women and 0.29 (95% CI, 0.15 to 0.58) among men".

The analysis strongly suggested that coffee regardless of type has a negative correlation with the risk of diabetes through increasing levels of SHBG.

Additionally, according to the cross-sectional study of 2377 nondiabetic pre-and postmenopausal women from the E3N cohort study in a multivariate-adjusted model, intake of more than 3 cups of coffee daily coffee and caffeine ≥265 mg/day was associated with an increased SHBG level distribution (<46.3 nmol/L), in compared to no risk association of decaffeinated coffee subgroup.

In other words, in low levels of SHBG nondiabetic pre- and postmenopausal in compared to healthy women, injection of caffeinated coffee increased levels of sex hormones estrogen and testosterone

The above analysis was supported by the examination of the study during a median follow-up of 10 years of 359 postmenopausal women with newly diagnosed type 2 diabetes matched with 359 control subjects by age, race, duration of follow-up, and time of blood draw, coffee, and caffeine were associated with increased levels of free and total testosterone among postmenopausal women.

In Summary, the evidence indicated that coffee and caffeine have an extreme effect in an exhibition of the sex hormone estrogen and testosterone through the increased lower level of SHBG in menopausal women and prevented the onset of type 2 diabetes without affecting the serum in healthy individuals.

Decaffeinated coffee decreased total and free testosterone through significantly increased levels of SHBG in overweight women who are at risk of diseases associated with overexpression of testosterone.

And caffeinated coffee displayed a significantly increased total testosterone and decreased total and free estradiol in men.

Altogether, coffee may be considered as a functional food in the mediated production of sex hormone estrogen and testosterone against diseases and syndromes caused by low levels of SSBG.

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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The effects of caffeinated and decaffeinated coffee on sex hormone-binding globulin and endogenous sex hormone levels: a randomized controlled trial by Wedick NM1, Mantzoros CS, Ding EL, Brennan AM, Rosner B, Rimm EB, Hu FB, van Dam RM.(PubMed)
(2) Cross-sectional association of coffee and caffeine consumption with sex hormone-binding globulin in healthy nondiabetic women by Pihan-Le Bars F1,2, Gusto G3,4,5, Boutron-Ruault MC3,4,5, Fagherazzi G3,4,5, Bonnet F1,2,3.(PubMed)
(3) Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women by Goto A1, Song Y, Chen BH, Manson JE, Buring JE, Liu S.(PubMed)

Herbal #AniseOil Removes the Symptoms of Mild to Moderate #Depression in Patients with Irritable Bowel Syndrome, Researchers Show

Kyle J. Norton

Anise may have a potential and substantial effect on the treatment of depression, some scientists suggested.

Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, antiseptic, anti-spasmodic,...

Chemical constituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

Depression is a condition of a mood disorder. affecting the patients' feel, think, and handle daily activities.

According to the statistic of The National Institute of Mental Health, approximately, 16 million adults had at least one major depressive episode in 2012 in the United States, 6.9 percent of the population.

In the evaluation of the herbal Anise aqueous and ethanol extracts antidepressant-like effects in mice with several different doses of 50, 100, and 200 mg/kg in compared to the standard medicine Fluoxetine at the dose of 30mg/kg and imipramine at a dose of 20mg/kg, researchers at the joint study lead by the Azad University showed that except for the dose at 50mg/kg of aqueous extract, application of other doses demonstrated a linearly significant improvement of mobility times.

Further analysis also found that all doses from Anise extract increased the swimming time dose-dependently, without any significant change in climbing time in tested mice similar to those of Fluoxetine and in compared to aqueous extract.

Moreover, Fluoxetine and imipramine expressed a strong decreased immobility time in both tests in contrast to imipramine's increased climbing time without any significant change in swimming time.

The result suggested that both extracts in a dose higher than 50mg/kg display antidepressant-like activity similar to that of fluoxetine through improved mobility of depressed mice as inactivity is considered one of the major symptoms in patients with depression.

As the depression progress, patients demonstrated behavior in making efforts to escape from society and eventually will exhibit immobility with the reflection of psychological despair.

Dr. Shahamat Z the lead author said, " P. anisum possesses an antidepressant-like activity similar to that of fluoxetine, which has a potential clinical value for application in the management of depression".

Additionally, in the testing essential (volatile) oil and essential oil of Piper laetispicum antidepressant activity in compared to Fluoxetine as standard antidepressant drug and other natural remedies including Leaves-Bay, Curry, Coriander, and Mint; Fruits-Star anise, Pepper, Cardamom, Caraway and Fennel; Seeds of Fenugreek, Mustard, Nutmeg and Black Cumin; and Underground stem-Onion, Garlic, Ginger and Turmeric; Miscellaneous-Clove, Cinnamon, Capsicum, Tamarind and Asafoetida, researchers found that all participated in essential oil, especially anise produced a significant reduction in immobility along with an increase in climbing behavior similar to those of fluoxetine.


The application of essential oil caused a dose-dependent reduction( probably in a dose less than 50 mg/kg) in immobility which is contracted to the above study and an increase in climbing at all studied doses compared to a control group.

Furthermore, in the examination of the efficacy of anise oil, in removing the symptoms of mild to moderate depression in patients with irritable bowel syndrome a total of 120 were randomly assigned into 3 equal groups received anise oil, Colpermin, and placebo, at the end of the study, scientists showed that application of anise group exerted a continuous improvement of the syndrome compared to the other 2 groups with some unknown mechanisms.

Some researchers postulated that essential oil smell may have a profound effect on the brain in triggering an emotional reaction in stimulating the limbic system in regulated autonomic and endocrine function, particularly, in response to emotional stimuli in the expression of motivation and reinforcing behaviors.

Additionally, the application of essential oil scent also has a direct influence on calming the central nervous system in ameliorating the overproduction of certain hormones in reacting to unfavorably emotional behaviors.

Taken together, Anise essential oil may be used as a secondary therapy to standard medicine in the treatment of depression.


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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299


Sources
(1) Evaluation of antidepressant-like effects of aqueous and ethanolic extracts of Pimpinella anisum fruit in mice by Shahamat Z1, Abbasi-Maleki S2, Mohammadi Motamed S3.(PubMed)
(2) The effectiveness of Anise Oil for the Treatment of Mild to Moderate Depression in Patients With Irritable Bowel Syndrome. A Randomized Active and Placebo-Controlled Clinical Trial by Maryam Mosaffa-Jahromi, PharmD, Ph.D., Ali-Mohammad Tamaddon, PharmD, Ph.D., Suleiman Afsharypuor, PharmD, Ph.D., Alireza Salehi, MD, MPH, Ph.D., Seyed Hassan Seradj, PharmD, Ph.D., Mehdi Pasalar MD, MPH, Ph.D., Peyman Jafari, Ph.D., Kamran Bagheri Lankarani, MD (Journal of Evidence-Based Integrative Medicine)
(3) Essential oil isolation from culinary drugs and screening for antidepressant potential Mohib Abdul Jalil Khan, Imtiyaz Ansari, Amjad Ali Mohammad Iqbal Oriental College of Pharmacy, Navi Mumbai, Maharashtra- 400705, India. (INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACY MEDICINE AND BIOALLIED SCIENCES)
(4) The Forced Swim Test as a Model of Depressive-like Behavior by Roni Yankelevitch-Yahav, 1, 2 Motty Franko, 2 Avrham Huly, 2 and Ravid Doron(PMC)

#Isothiocyanates-#Sulforaphane Shows a Siginificantly Neuroprotective Effect Against Dopaminergic Neurotoxicity, According to Studies

Kyle J. Norton

Dithiolthiones, the bioactive compound found abundantly in the cruciferous vegetables may have a potential effect on reducing the risk of neurodegenerative disease, some scientists found.

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

A neurodegenerative disease is a group of conditions which primarily affect the neurons in the brain, including Parkinson's disease (PD) and Alzheimer's disease.

In other words, a neurodegenerative disease is caused by the progressive death of neurons in different regions of the nervous system.

The progressive loss of neurons induced neurological and neuropsychological signs and symptoms have also been found in comparison to the stage of disease onset of patients.

The causes of neurodegenerative diseases are unknown, However, researchers do know that the increase in age is one most consistent risk factors for developing a neurodegenerative disease, especially AD or PD, as the disease has been found in over 60% of the population aged 65 and beyond compared to another group.


And these numbers are found to increase at an alarming rate. Dr. Serge Przedborski, the lead author in the investigation of the risk of neurodegenerative disease in the elderly said, "It can be anticipated that, over the next generations, the proportion of elderly citizens will double, and, with this, possibly the proportion of persons suffering from some kind of neurodegenerative disorder".

Epidemiologically, geographical, hereditary and viral and toxicological exposure correlates and deficiencies of elements such as calcium and selenium are some of the risk factors in the development of neurological diseases.

Also, people who follow the Western diet pattern are at the increased risk of the disease. According to the 2018 Alzheimer's Association International Conference, July 22-26, 2018 in Chicago, Illinois, the Western diet is known to include high consumption of red meats, processed meats, as well as fatty and fried foods. This dietary pattern has been linked to a greater risk of cognitive decline and dementia.

As the autopsied participants' brains followed the Western diet showed a significant change of neuropathologies such as β-amyloid plaques, tau tangle density, neocortical Lewy bodies, cerebral atherosclerosis, among others.

This analysis may indicate that by changing to a healthy diet with a high in fruits and vegetables and whole grain and less in saturated and trans fat, red meat and processed foods, the risk of neurodegenerative disease can be reduced substantially.

Researchers In the finding of a natural ingredient or whole food investigated epidemiologically suggested that sulforaphane, an organosulfur compound present in cruciferous vegetables processed neuroprotective effects in experimental in vitro and in vivo models of neurodegeneration. Using the Morris water maze researchers tested the sulforaphane effects on scopolamine-induced memory impairment in mice.

Sulforaphane (10 or 50mg/kg) was administered to C57BL/6 mice by oral gavage for 14 days (days 1-14), Memory impairment was induced by intraperitoneal injection of scopolamine (1mg/kg) for 7 days (days 8-14).

Mice receive an injection of scopolamine showed impaired learning and memory retention and considerably decreased cholinergic system reactivity in the hippocampus and frontal cortex. The results were observed by a decreased acetylcholine (ACh) level and increased acetylcholinesterase (AChE) activity.

Where acetylcholine (ACh) is a neurotransmitter, associated with the function of sending signals to other cells [neurons, muscle cells, and gland cells] and acetylcholinesterase (AChE) is an enzyme that catalyzes the breakdown of acetylcholine.

Treatment of sulforaphane significantly attenuated the scopolamine-induced memory impairment and improved cholinergic system reactivity.

In other words, sulforaphane exerted a neuroprotective effect against the scopolamine in the induction of oxidative stress to the neurons. Sulforaphane at the doses of 10 or 20μM increased the ACh level, decreased the AChE activity, and increased ChAT expression in scopolamine-treated primary cortical neurons.

Dr. Lee S, the lead scientists suggest "Sulforaphane might exert a significant neuroprotective effect on the cholinergic deficit and cognitive impairment".


Additionally, in the concern of no drugs treatment of schematic/traumatic brain injury, Alzheimer's disease, and Parkinson's disease which share common characteristics such as oxidative stress, misfolded proteins, excitotoxicity, inflammation, and neuronal loss, researchers investigated the effect of sulforaphane against the mentioned diseases.

In several in vitro and in vivo studies isothiocyanate sulforaphane, derived from the hydrolysis of the glucosinolate glucoraphanin mainly present in Brassica vegetables, has demonstrated neuroprotective effects.

The efficacy was attributed to the activity of sulforaphane in activating the Nrf2/ARE pto Studiesathway in modulating the expression of oxidative stress.


Dr. Tarozzi A, the lead author in the final report of the experiment wrote, "Sulforaphane appears to be a promising compound with neuroprotective properties that may play an important role in preventing neurodegeneration".

More importantly, in dopaminergic neurotoxicity in mice induced by 6-hydroxydopamine (6-OHDA), the phytochemical showed a neuroprotective effect through its ability to enhance the antioxidant enzymes of the host and improve neuronal survival.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Sulforaphane alleviates scopolamine-induced memory impairment in mice by Lee S1, Kim J1, Seo SG2, Choi BR3, Han JS3, Lee KW4, Kim J5. (PubMed)
(2) Sulforaphane as a potential protective phytochemical against neurodegenerative diseases byTarozzi A1, Angeloni C, Malaguti M, Morroni F, Hrelia S, Hrelia P.(PubMed)
(3) Neuroprotective effect of sulforaphane in a 6-hydroxydopamine-lesioned mouse model of Parkinson's disease byMorroni F1, Tarozzi A, Sita G, Bolondi C, Zolezzi Moraga JM, Cantelli-Forti G, Hrelia P.(PubMed)
(4) Series Introduction: Neurodegeneration: What is it and where are we?by Serge Przedborski,1,2,3 Miquel Vila,1 and Vernice Jackson-Lewis. (PMC)

#Herbal #Catnip #EssentialOil Exerts Antioxiidant Activity Against Diseases Associated with #ChronicInflammation, Studies Suggest

Kyle J. Norton

Scientists may have found a natural ingredient in reducing the risk and treatment of chronic inflammatory diseases, some studies suggested.

Inflammation is a systematic immune response caused by the production of proinflammatory cytokine activated by the white blood cells in the immune system responsible for the first line of defense.

In the early phase of bodily injury and damage, the reaction of the immune system also encompasses a wide range of pathophysiological responses to minimize tissue damage while enhancing the repair process.

Inflammation also can be caused by viruses and bacteria, some of the most common stimuli of inflammation by either entering or destroying the host body cells or producing endotoxins, respectively.

Malfunctioning immunological responses attack the body tissue and can incite inappropriate and chronic inflammation.

Believe it or not, tissues that die from a lack of oxygen or nutrients can also cause inflammation.


Chronic inflammation in another hand, is caused by the immune response that can not kill off all infectious agents in the acute phase of infection.


Some researchers argued that the evolution of the immune system is to kill off all infectious stimuli or pathogens within 3 - 8 weeks, otherwise, the immune system will adapt to their existence, in other words, chronic inflammation.

Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia.

The plant has been used in herbal medicine as an insect repellant and to treat digestive disorders, children's restlessness and nervousness, fevers, cold and flu, skin irritation stimulates sweating, promote menstruation, etc.

Besides the major constituent of terpenoid nepetalactone, herbal catnip also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Thymol, Nepetalactone, Nepetalactone, etc.

On finding an effective anti-inflammatory natural ingredient or whole food with little or side effects, researchers at the Bangabandhu Sheikh Mujib Medical University examined herbal Catnip antinociceptive and anti-inflammatory activities.


A total of 24 male Wister rats weighing 225 ± 25 gm were included in the study, the experimental groups. were randomly injected with essential oil of NP intraperitoneally at the doses of 50 mg/kg, 100 mg/kg, and 200 mg/kg with control rats receiving equal volume (2 ml/kg) of normal saline.

All the doses of essential oil of herbal Catnip showed a strong antinociceptive activity compared to the control.

The highest dose of 200 mg/kg reduced the pain sensation in the tail-flick (p <0.01), according to the formalin test.

Injection of the dose at 100 and 200 mg/kg significantly reduced the inflammation in the tested subject's paw edema.

These results suggested that the natural ingredient of herbal Catnip essential oil may minimize both the acute and chronic forms of nociception and may have a potential role against inflammation.

Furthermore, the study by Tarbiat Modares University to evaluate the similar effect of Catnip filed a similar result.

Using the tail-flick and formalin test pain models and the paw edema model of inflammation similar to those of the above study in the male Wistar rats, the application of essential oil dose-dependently produced analgesia in the acute pain models, including the tail-flick and the first phase of the formalin test.

In the late phase of the formalin test, as a model of chronic pain, the essential oil significantly reduced pain-induced behavior.

Injection of essential oil exerted a potent anti-inflammatory effect found in the formalin-induced paw inflammation model and a significant reduction of paw edema in all applied doses.
The efficacy of herbal Catnip essential oil inhibited both acute pain and chronic pain and inflammation probably was attributed to its interaction with both the central and peripheral nervous system.

Taken together, Herbal Catnip may be considered an anti-inflammatory herbal medicine for the prevention and combined with the primary therapy for the treatment of chronic inflammatory disease without inducing any side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Evaluation of the antinociceptive and anti-inflammatory effects of essential oil of Nepeta pogonosperma Jamzad et Assadi in rats by Ali T, Javan M, Sonboli A, Semnanian S.(PubMed)
(2) Antinociceptive and anti-inflammatory activities of the essential oil of Nepeta crispa Willd. in experimental rat models by Ali T, Javan M, Sonboli A, Semnanian S.(PubMed)

#Capsaicin Found in #CayennePeppers Shows a Significantly Deeper Decrease in #Rhinorrhea and Nasal Blockag, According to Studies

Kyle J. Norton


Herbal cayenne may be a pharmaceutical target to identify the single-ingredient medicine for the treatment of allergic rhinitis with no side effects, some scientists suggested.

Nonallergic rhinitis is a condition with symptoms resembling an allergy cause of rhinitis but without a known cause.

Chronic forms of rhinitis occurred in the absence of any detectable specific IgE against relevant aeroallergens in its broadest sense can be called chronic nonallergic rhinitis.

Allergic rhinitis is caused by the immune overreaction when a person breathes in an allergen such as pollen, mold, animal dander, or dust, leading to the irritation and inflammation of the mucous membrane inside the nose.

The most common symptoms of allergic rhinitis are a stuffy nose, runny nose, sneezing, and post-nasal drip.

In contrast to general belief, allergic rhinitis is not a syndrome that comes and goes depending on the seasons.

Untreated allergic rhinitis can lead to complications of chronic nasal inflammation and obstruction, a leading cause of upper respiratory tract infection.

There is some strong evidence suggesting that allergic rhinitis can affect the quality of life, productivity, and other comorbid conditions, including asthma.

The World Health Organization in the differentiation of the condition, suggests that the treatment of allergic rhinitis should include a combination of patient education, allergen avoidance, pharmacotherapy, and immunotherapy

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions.

The kitchen spice has been used in traditional medicine to increase metabolism, enhance the circulatory system and stomach and intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.

The chemical constituents of Cayenne include capsaicin, capsacutin oil, solaine, xanthenes, oleic acid, palmitic acid, etc.

In finding a natural formula for the treatment of allergic rhinitis with no side effects, researchers at the University of Cincinnati College of Medicine examine the efficacy and safety of ICX72 or Sinus Buster, a proprietary homeopathic preparation of Capsicum annum and Eucalyptol, versus placebo.

In the total of Forty-two consented subjects meeting inclusion/exclusion criteria randomized to ICX72 (n = 20) or control (n = 22) administered twice daily over 2 weeks, the primary endpoint was changed in total nasal symptom scores (TNSS) from baseline to end of the study.

During the study, the application of ICX72 exhibited significant differences in changes from baseline to end of the study for TNSS and each ISS (P < .01), compared to placebo.

ICX72 exerted a significantly faster relief at 52.6 seconds.

The formula also improved nasal congestion, sinus pain, sinus pressure, and headache at 5, 10, 15, and 30 minutes, persisting at 60 minutes for nasal congestion and sinus pain.


No subjects experienced rebound congestion or impaired olfaction at the end of the study.

There is no adverse effect in the treatment group.

These results firmly suggested that intranasal capsaicin used continuously over 2 weeks, rapidly and safely improves symptoms in rhinitis subjects with a significant NAR component.


For further analysis of the effect of intranasal capsaicin, researchers conducted a double-blind double-dummy parallel groups trial to determine whether a more practical capsaicin application schedule is equally effective.

Thirty patients were randomized into two different treatment regimens: one group received capsaicin five times on the first day at 1-h intervals, followed by a placebo dummy once every second or third day for a total of five treatments 2 weeks after the capsaicin application (group A).

The other group (B) received the placebo dummy five times on the first day followed by capsaicin once every second or third day for a total of five treatments 2 weeks after the placebo application.

According to the reading, visual analog scale scores for overall nasal symptoms, group A showed a significantly deeper decrease in rhinorrhea and nasal blockage, compared to group B.

There is a significant reduction in the cold dry air responsiveness up to 9 months after therapy in both groups, reflecting a decrease in nasal hyperreactivity.


Taken together, Herbal cayenne containing the bioactive compound capsaicin may be considered a functional spice for the treatment of allergic rhinitis with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Nonallergic rhinitis by Lieberman P1, Pattanaik D.(PubMed)
(2) A randomized, double-blind, parallel trial comparing capsaicin nasal spray with placebo in subjects with a significant component of nonallergic rhinitis by Bernstein JA1, Davis BP, Picard JK, Cooper JP, Zheng S, Levin LS. (PubMed)
(3) Intranasal capsaicin reduces nasal hyperreactivity in idiopathic rhinitis: a double-blind randomized application regimen study by Van Rijswijk JB1, Boeke EL, Keizer JM, Mulder PG, Blom HM, Fokkens WJ. (PubMed)

#GarlicExtract (BGE), Shows a Significant Inhibition Against the Growth of #LungCancer Cells Through Interference on Tumor Cell Division and Proliferation

Kyle J. Norton


Herbal medicine, the study of botany that uses the plant for medical treatment and cure, linking health benefits in the prevention, management, and treatment of diseases have been present in human history for thousands of year.

Today, the whole herb treatment has drawn much interest from some conscientious scientists.

However, the journey of finding the specific whole food medicine for the treatment of diseases has encountered many obstacles, because of lacking financial support from commercial institutes and opposition by the big pharmaceutical companies.

Not only the discoveries cannot be patented, but they can also cause a substantial drop in their profits.

Many researchers have raised the question of the quality of the herbs used in experiments as geographic differences, time of growth and harvest may affect the potency.

Truly, although herbal plants have formed a fundamental source for conventional medicine, the big drug companies only interest in the discovery of single-ingredient medication, such as aspirin is synthesized from willow bark, quinine, synthesized from cinchona bark), and morphine,......and synthesized from the opium poppy......

Lung Cancer is a chronic condition characterized by irregular and uncontrollable cell growth in the lung tissue, originally. At the advanced stage, the cancerous cells can travel a distance away from the lung to infect other healthy organ tissue.


In Canada, Lung cancer not only is the most commonly diagnosed cancer after melanoma skin cancers. it also is a leading cause of death in both men and women.
According to the Canadian Cancer Society(6), In 2017, an estimated:
* 28,600 Canadians were diagnosed with lung cancer. This represents 14% of all new cancer cases in 2017.

* 21,100 Canadians died from lung cancer. This represents 26% of all cancer deaths in 2017.14,400 men were diagnosed with lung cancer and 11,100 died from it.

* 14,200 women were diagnosed with lung cancer and 10,000 died from it.

* On average, 78 Canadians were diagnosed with lung cancer every day.

* On average, 58 Canadians died from lung cancer every day.

Long-term cigarette smoking, second-hand smoke, and exposure to chemical smoke are the major causes of the disease.

And the symptoms of lung cancer include a persistent cough that does not go away,
coughing up blood or rust-colored sputum (spit or phlegm), chronic chest pain that is often worse with deep breathing, coughing, or laughing, shortness of breath,.....and weight loss and loss of appetite.

In the advanced stage of lung cancer patients may also experience symptoms of coughing up blood or rust-colored sputum (spit or phlegm).

According to the joint study led by the Sun Yat-sen University Cancer Center, " The suicide mortality rates have significantly decreased (before 1993: 0.21%, 1994-2003: 0.16%, after 2004: 0.09%, P < .001). Male (OR 6.22, 95% CI: 4.96-7.98, P < .001), white (OR 3.89, 95% CI: 2.66-5.97, P < .001), being unmarried (OR 1.43, 95% CI: 1.22-1.67, P < .001), the elderly (60-74 vs <60: OR 1.24, 95% CI: 1.03-1.50, P = .024, >75 vs <60: OR 1.31, 95% CI: 1.05-1.63, P = .018) were independently associated with higher risk of suicide mortality" and "Surgery (OR: 1.44, 95% CI: 1.19-1.73, P < .001) was also relative with higher risk of suicide"(7).

A recent study suggested that garlic may be used as a chemoprevention and treatment of lung cancer.

Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia.

The herb has been used popularly in traditional and Chinese medicine for the treatment of the common cold and flu to the Plague, blood pressure cholesterol levels,...... and as a natural antibiotic.
According to the study by Medical Research Center, College of Medicine, allyl sulfur compounds and garlic extract found in garlic exhibited anti nonsmall cell lung cancer cell lines effects through interference on tumor cell division and proliferation.

In benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells, application of oil-soluble organosulfur compounds from garlic induced suppression of cell proliferation, cell cycle regulation, attenuation of ROS formation, inhibition of DNA damage.


The examination of the association between raw garlic consumption and lung cancer, a case-control study conducted between 2005 and 2007 in Taiyuan, China, showed that compared with no intake, raw garlic intake is associated with a lower risk of development of lung cancer with a dose-response pattern.

In fact, the epidemiologic data collected by face-to-face interviews using a standard questionnaire among 1,424 lung cancer cases and 4,543 healthy controls also supported the negation of garlic intake and lung disease and suggested that garlic may potentially serve as a chemopreventive agent for lung cancer.

Dr. Yang GQ, the lead researchers at the 107th Hospital of the People's Liberation Army said, "Black garlic extract (BGE) could have a significant inhibitory action on the growth of lung cancer Lewis cells. The combination of BGE and radiotherapy (by 60Co gamma) significantly induced Lewis cells' apoptosis in the G2/M stage".

Therefore, adding a portion of garlic to your diet may be beneficial for increased protection against lung cancer development.

However, further data collection on large sample sizes and multi-center clinical studies performed with human consumption during the course of the investigation will be necessary to complete the picture of garlic and its bioactive compounds' protective effect against lung cancer possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of allyl sulfur compounds and garlic extract on the expression of Bcl-2, Bax, and p53 in nonsmall cell lung cancer cell lines by Hong YS1, Ham YA, Choi JH, Kim J.(PubMed)
(2) Inhibitory effects of S-allylmercaptocysteine against benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells by Wang K1, Wang Y1, Qi Q1, Zhang F1, Zhang Y2, Zhu X1, Liu G1, Luan Y1, Zhao Z3, Cai J4, Cao J4, Li S4.(PubMed)
(3) Raw Garlic Consumption and Lung Cancer in a Chinese Population by Myneni AA1, Chang SC2, Niu R3, Liu L4, Swanson MK1, Li J5, Su J5, Giovino GA6, Yu S5, Zhang ZF2, Mu L7.(PubMed)
(4) Raw garlic consumption as a protective factor for lung cancer, a population-based case-control study in a Chinese population by Jin ZY1, Wu M, Han RQ, Zhang XF, Wang XS, Liu AM, Zhou JY, Lu QY, Zhang ZF, Zhao JK.(PubMed)
(5) [Radiosensitization effect of black garlic extract on lung cancer cell line Lewis cells].[Article in Chinese] byYang GQ1, Wang D, Wang YS, Wang YY, Yang K.(PubMed)
(6) Lung cancer statistics of Canadian Cancer Society
(7) Trends in incidence and associated risk factors of suicide mortality in patients with non-small cell lung cancer by Zhou H1,2,3,4, Xian W4, Zhang Y1,2,3, Chen G1,2,3, Zhao S1,2,3, Chen X1,2,3, Zhang Z1,2,3, Shen J4, Hong S1,2,3, Huang Y1,2,3, Zhang L(PubMed)

#HN-02, an Extract Containing a Mixture of #Andrographolides Found in Andrographis Enhances Immune Function by Modulating the Immune Responses, Scientists Say

Kyle J. Norton

Herbal Andrographis paniculata may have a profound effect in enhancing the function of the immune system against diseases development, some studies found.

The immune system is a set of cells which have a unique function to protect our body against antigens or infectious agents that comprises of the body's defense system against diseases.

The immune system does a great job of keeping people healthy and preventing infections.

It is a made of special cells (white blood cells), antibodies, tissues (bone marrow), and organs (the spleen) defend people against germs and microorganisms every day.

3 types of immunity can be classified as the following
* The innate immunity is also known as natural immunity that every human born with.

* The adaptive immunity is the type of immunity that develops in the life of the individual.

* Passive immunity that borrows from outside sources and can only last only a short period

There are 2 types of immune disorders
* Underactive immunity or immune deficiency. People with an underactive immune system are easy
to be infected or sick all the time

* Overactive immune system or autoimmune diseases. In this case, the immune system attacks the host tissue, causing autoimmune diseases such as rheumatoid arthritis (RA).

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.

The plant has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.

In finding a natural ingredient or formula for the treatment of immune dysfunction with no side effects, researchers at the Prin. K. M. Kundnani College of Pharmacy, launched an investigation to examine the immunomodulatory activity of HN-02, an extract containing a mixture of andrographolides.

The pure powder form of the mixture of andrographolides.was evaluated at 1.0, 1.5, and 2.5 mg/kg on different in vivo and in vitro experimental models.

Application of the mixture delayed-type hypersensitivity (DTH) caused by the injection of cyclophosphamide (CYP) in the mouse model.

Where cyclophosphamide (CP) is a medication used as chemotherapy and to suppress the immune system.

HN-02 treatment elevated the depressed hemagglutination antibody (HA) titer, the antibody and increased the number of plaque-forming cells (PFCs) in the spleen cells of mice caused by injection of CYP.

HN-02 treatment stimulated phagocytosis in the immune system and increased levels of white blood cells in the tested mice.

These results strongly indicated HN-02 has the ability to enhance immune function by modulating the immune responses which were altered during antigen interaction and reversing the immunosuppression induced by CYP.

Furthermore, according to the Amala Cancer Research Centre in the examine the natural whole herb function in the modulation of immune responses against tumor cells, Andrographis paniculata extract (APE) and its isolated compound andrographolide (ANDLE) exert a clinically significant effect on cell-mediated immune responses in normal and tumor-bearing control animals.

Treatment with APE and ANDLE significantly enhanced natural killer cell activity in normal and tumor-bearing animals on the fifth day,

Antibody-dependent cellular cytotoxicity was also increased in APE as well as ANDLE on day 11-treated normal and tumor-bearing animal compared to untreated tumor-bearing control animals.

Moreover, treatment of APE and ANDLE significantly elevated the production of interleukin-2 which regulates the activities of white blood cells (leukocytes, often lymphocytes) and interferon-gamma which is critical for innate and adaptive immunity in normal and Ehrlich ascites carcinoma-bearing animals.

These results firmly indicated that herbal Andrographis may be considered functional food in the enhancement of the immune function against foreign stimuli and micro pathogens.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Evaluation of the immunomodulatory activity of an extract of andrographolides from Andographis paniculata by Naik SR, Hule A.(PubMed)
(2) Modulation of natural killer cell activity, antibody-dependent cellular cytotoxicity, and antibody-dependent complement-mediated cytotoxicity by andrographolide in normal and Ehrlich ascites carcinoma-bearing mice by Sheeja K, Kuttan G.(PubMed)
(3) Activation of cytotoxic T lymphocyte responses and attenuation of tumor growth in vivo by Andrographis paniculata extract and andrographolide by Sheeja K, Kuttan G.(PubMed)