Beta-Sitosterol Improves the Intestinal Cholesterol Absorption

By Kyle J. Norton

Cholesterol is a waxy substance that is produced either by the liver or injected from animal food sources.

Cholesterol found in our body is needed to build cell walls, hormones, and vitamin D, and create bile salts that aid digestion. However, too much of them, in most cases due to the intake of animal protein can cause plaques to build up on the arterial wall, the major cause of heart disease and stroke.

More precisely, if levels of low-density lipoprotein are high compared to high-density lipoprotein which returns the accessed cholesterol back to the liver, you have high blood cholesterol.

Lipid metabolism is the breakdown of lipids in cells for energy.

The intestines formed part of the digestive system including the small and large intestines are long, continuous tubes running from the stomach to the anus.

The small intestine demonstrated 90% of the digestion and absorption of food compared to only 10% in the stomach and large intestine.

More precisely, the large intestine not only plays an essential in the recovery of water and electrolytes, formation, but also storage of feces and fermentation of some of the indigestible food matter by bacteria.

The intestinal cholesterol absorption includes two main phases, according to Medscape, "The first takes place in the lumen and involves digestion and hydrolysis of dietary lipids followed by solubilization of cholesterol in mixed micelles containing bile acid and phospholipids. This solubilization facilitates the movement of cholesterol from the bulk phase of the lumen to the surface of the enterocyte".

And, "In the second phase, cholesterol crosses the mucosal cell membrane by simple diffusion, and probably by facilitated diffusion as well".

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, and buckwheat. etc.

In finding a potential phytochemical for the prevention of diseases involving hyper cholesterol researchers investigated the anti-hyper cholesterol activity of β-sitosterol (BSS).

The study included rabbits that were fed either 10% coconut oil, 10% coconut oil and 1% beta-sitosterol, 10% coconut oil, and 1% cholesterol, or 10% coconut oil and 1% beta-sitosterol plus 1% cholesterol for 4 weeks.
According to the results of the experiment,
* Microsomal membranes from the intestines of animals fed the 1% beta-sitosterol diet had 48% less cholesterol compared to membranes from animals fed the coconut oil diet.
* The acyl-coenzyme A: cholesterol acyltransferase (ACAT) activity that forms cholesteryl esters from cholesterol in jejunum and ileum was decreased significantly in animals fed the plant sterol alone.

In the membranes from animals fed 1% beta-sitosterol and 1% cholesterol, beta-sitosterol content showed an increase of 50% whereas cholesterol was modestly decreased compared to their controls fed only cholesterol.

Furthermore, animals fed 1% beta-sitosterol, did not interfere with the stimulation of ACAT activity secondary to cholesterol enrichment of the membranes.

Most importantly, freshly isolated intestinal cells incubated for 1 hour with [(3)H]oleic acid and beta-sitosterol: DPPC or 25-hydroxycholesterol: DPPC incorporation of oleic acid into cholesteryl esters did not change in the presence of beta-sitosterol but increased fourfold after the addition of 25-hydroxycholesterol, an indication of improved immune functioning.

Based on the results, researchers wrote, "the CoA-dependent esterification rate of cholesterol is at least 60 times greater than that of beta-sitosterol. Membrane beta-sitosterol does not interfere with nor competes with cholesterol esterification"

And "Inadequate esterification of this plant sterol may play a role in the poor absorption of beta-sitosterol by the gut.".

Taken altogether, beta-Sitosterol may be considered a supplement for the improvement of intestinal cholesterol absorption, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) beta-sitosterol: esterification by intestinal acylcoenzyme A: cholesterol acyltransferase (ACAT) and its effect on cholesterol esterification by Field FJ, Mathur SN. (PubMed)
(2) The Intestinal Absorption of Biliary and Dietary Cholesterol as a Drug Target for Lowering the Plasma Cholesterol Level by Stephen D. Turley, PhD, John M. Dietschy, MD. (Medscape)

#Healthyfood #Green Tea Ameliorates Symptoms and Progression of Rheumatoid Arthritis(RA), According to Studies

Kyle J. Norton

Green tea exhibited anti-inflammatory effects in reduced symptoms and progression
regarding Rheumatoid Arthritis, some institutes suggested

Rheumatoid Arthritis is a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body.

According to statistics, In the US, approximately, 90 million adults and children suffered directly from arthritis, inducing social and economic consequences to over 240 million people who are having a family member affected by the disease.

The disease was also found to infect a third of those aged 18-64.

Although the disease is caused by an immune defense attacking the body's healthy tissue, researchers today are not sure what triggers the abnormal function. But they do know that certain risk factors are associated with an increased risk of rheumatoid arthritis, including genetic alternation, as people with certain genes are more likely to develop RA, geographic factors as RA is rare in less developed and rural parts of the world, hormone factor as RA is more common in women than in men,.... and family history.

Other risk factors including smoking, people with certain medical conditions such as autoimmune disease, unhealthy diets such as high in red meat and less in fruits and vegetables, and physical inactivity also promote the early onset of RA.

The Karolinska Institutet in the study of the risk factors of RA wrote, "nongenetic risk factors (smoking, alcohol intake, parity, silica exposure, body mass index, fatty fish consumption, and education), and genetic risk factors (shared epitope [SE] and 76 single-nucleotide polymorphisms [SNPs])" and "....many (familial) risk factors remain to be identified, in particular for seronegative RA"(4).

The results of chronic inflammation caused by the immune attacking the joints, inducing over-expression of pro-inflammatory cytokines can lead to damage of cells in the inflammatory site and nearby healthy cells, including bone, cartilage, tendons,.... and ligaments,

Untreated chronic joint inflammation can also cause complications of total destruction of joint tissue.

If you experience symptoms of joint pain, tenderness, swelling, redness, stiffness,.... restriction, or loss of joint range of motion, you may have RA.

Green tea, a precious drink processed a number of health benefits and is known to almost everyone in Asia and the Western world.

According to the joint study led by Washington State University College of Pharmacy, green tea showed to ameliorate the expression of pro-inflammatory mediators including (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs), through the effects of its phytochemical compounds of EGCG and EGC antioxidant activities.

IL-6 and IL-8 are pro-inflammatory cytokines activated by a systematic immune response in preventing damage to tissue in the acute phase of infection. Prolonged over-expression of IL6 and IL8 can cause damage to cells in the infectious region as well as surrounding healthy cells.

Cox-2 are prostaglandins with function in mediated pathogenic infection, including the inflammatory response.

Dr. Fechtner S, the lead researcher said," EGCG is the most effective catechin at inhibiting downstream inflammatory signaling, its effectiveness could be hindered by the presence of (epicatechin) EC".

In the investigation of the anti-inflammatory activity of green versus black tea aqueous extract in a rat model with orally/daily distilled water as placebo, indomethacin (1.0 mg/kg body weight; a non-steroidal/anti-inflammatory drug), or tea aqueous extracts (for 28 or 14 consecutive days administrated from day 0 or 14 of arthritis induction, respectively), researchers found that group treats with a high dose of GTE (from day 0) significantly alleviated (P < 0.05-0.001) the progression and all complications induced by rheumatoid arthritis in compared to placebo.

More importantly, researchers also found that the expression of the anti-arthritic activity of the high dose of GTE (from day 0) was mediated by significantly decreasing the systemic production of pro-inflammatory cytokines and the expression of chemokine receptor-5, a protein in activated immune activities in the in synovial tissues, was comparable (P > 0.05) with that of indomethacin (12.9-53.8 vs. 9.5-48.4%, respectively).

Furthermore, the anti-arthritic potency of tea aqueous extracts was dosed dependent on the order of high dose of GTE > low dose of GTE ≥ high dose of BTE > low dose of BTE.

Another study suggested that green tea extract reduced symptoms and risk of complications probably the result of regulating chemokine(a family of cytokines secreted by cells) production in an immune reaction and chemokine receptor expression in interaction with proinflammatory cytokines of human RA synovial fibroblasts in rat adjuvant-induced arthritis (AIA).

Taken together, green tea may be served as a functional food to reduce symptoms and risk of complications for patients with rheumatoid arthritis.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Molecular insights into the differences in anti-inflammatory activities of green tea catechins on IL-1β signaling in rheumatoid arthritis synovial fibroblasts by Fechtner S1, Singh A1, Chourasia M2, Ahmed S3.(PubMed)
(2) Anti-inflammatory activity of green versus black tea aqueous extract in a rat model of human rheumatoid arthritis by Ramadan G1, El-Beih NM1, Talaat RM2, Abd El-Ghffar EA1.(PubMed)
(3) Green tea extract inhibits chemokine production, but up-regulates chemokine receptor expression, in rheumatoid arthritis synovial fibroblasts and rat adjuvant-induced arthritis by Marotte H1, Ruth JH, Campbell PL, Koch AE, Ahmed S.(PubMed)
(4) To what extent is the familial risk of rheumatoid arthritis explained by established rheumatoid arthritis risk factors? by Jiang X1, Frisell T, Askling J, Karlson EW, Klareskog L, Alfredsson L, Källberg H(PubMed)

Phytochemical Beta-Sitosterol Induces the Apoptosis of Breast Cancer Cells

By Kyle J. Norton

Cancer is a class of diseases in which a group of cells grow and multiply disorderly and uncontrollably in the body.

The breast is the tissue overlying the chest muscles. in women, breasts are made of specialized tissue that produces milk (glandular tissue) and fatty tissue. The size of the women's breasts is totally determined by the amount of fat.

Breast cancer is a medical condition characterized by cell growth irregularly and disorderly in the breast tissue.

Most cases of breast cancer start in the cell on the surface of the inner lining of the breast tissue before spreading into deeper layers of the breast.

In the early stage, most patients with breast cancer may experience lumps on the breast or surrounding the breast.

However, breast skin irritation or dimpling, nipple pain, nipple retraction (turning inward), redness and scaliness that cannot be healed within 3 weeks are also the signs and symptoms of breast cancer.

At the later stage, after colonizing most parts of the breast, the breast cancer cells may travel a distance far the way to infect other healthy cells and tissue.

According to the statistics provided by the American Cancer Society, in the U.S. approximately, 1 in 8 U.S. women (about 12%) will develop invasive breast cancer over the course of their lifetime.

In 2019, approximately 268,600 new cases of invasive breast cancer will be diagnosed in women in the U.S., along with 62,930 new cases of non-invasive (in situ) breast cancer.

The 5 years survival rate of breast cancer diagnosed at the early stage is close to 100%.

In Canada, according to statistics, 11% of women will develop breast cancer by the time they reach 90 years of age.

Just about 20% of breast cancers in Canada are diagnosed in women under 50, while almost 30% are diagnosed in women over 70 years of age.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belonging to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of cancer, researchers examined the effect of beta-Sitosterol found in legumes, oilseeds, and unrefined plant oils as found in foods such as peanut butter, pistachios and sunflower seeds against breast cancer cells.

According to the results of the experiential differentiation, beta-sitosterol application promotes its enrichment in transformed cell membranes against cancer cell activity and significantly inhibits tumor cell growth.

Concurrently, beta-sitosterol application also increased the activity of the pro-apoptotic protein such as the Fas and caspase-8 against the tested cancer cell lines.

Based on the findings, researchers wrote, " beta-sitosterol is an effective apoptosis-promoting agent and that incorporation of more phytosterols in the diet may serve as a preventive measure for breast cancer".

Taken altogether, beta-Sitosterol may be considered a functional food for the prevention and treatment of breast cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) beta-Sitosterol activates Fas signaling in human breast cancer cells by Awad AB1, Chinnam M, Fink CS, Bradford PG. (PubMed)

Honey May Be A Natural Depressant For the Treatment of Depression, Researchers Suggest

By Kyle J. Norton

Depression is a psychological illness that affects a patient mentally, including thinking and feeling, and physically such as loss of interest in physical activity.

The exact causes of depression are not identified. However, some risk factors such as genetic predisposition, personality, stress, and brain chemistry are found to associate with the onset in patients with such a condition.

There are some types of depression which can be classified as follow
1. Seasonal affective disorder (SAD) is caused by changes in weather. The mood of patients is affected by the weather and time of the year.

2. Postpartum depression is associated with the mother who can not cope with change following the birth of a child.

3. Depression with psychosis is the most severe case of depression as patients have lived in the illusion and loss of touch with reality.

4. Dysthymia, a persistent depressive disorder, also called dysthymia (dis-THIE-me-uh), is considered a chronic form of mild depression.

Most cases of depression in conventional medicine are treated with medication such as selective serotonin reuptake inhibitors (SSRIs) and antidepressants, accompanied by psychotherapy.

If you take any aforementioned medicine, please make sure that you know all the side effects for preventive measures.


Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

In the course to find a natural agent for the treatment of depression with no side effects, researchers evaluated the chemical compound chrysin found abundantly in honey against chronic unpredictable mild stress (CUMS).

The study included a 28-day oral treatment with chrysin (5 or 20mg/kg) in female mice subjected to CUMS, compared to the effect of fluoxetine.

Before treatment of chrysin, CUMS applied for 28days induced a decrease in brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) levels as well as in the Na(+), K(+)-ATPase activity.

Where brain-derived neurotrophic factor (BDNF ) as a neurotransmitter modulator, plays an important role in neuronal survival and growth as well as in learning and memory.

Nerve growth factor (NGF) is a neurotrophic factor involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. Reduced levels of nerve growth factor (NGF) has been found in patients with depression.

Na + /K + -ATPase is an enzyme with a function in maintaining resting potential, affects transport, and regulates cellular volume.

Clinical evidence suggested that Na+, K+-ATPase-induced activation of intracellular signaling participates in the mechanisms underlying patients with mood disorder.

Chrysin (20mg/kg) and fluoxetine improved the BDNF and NGF levels in non-stressed mice and in CUMS treatment mice.

Injection of chrysin and fluoxetine treatments also exerted an antidepressant effect by protecting the CUMS rats against all alterations of the decreased production of antioxidant enzymes and increased oxidative stress.

Based on the findings, Dr. Filho CB, the lead scientists, "the up-regulation of BDNF and NGF levels is a mechanism possibly involved in the antidepressant effect of chrysin in mice".

Furthermore, in order to reveal more information about the honey antidepressant property, researchers examined investigated the effect of chrysin in mice exposed to unpredictable chronic stress (UCS).

In UCS applied for 28 days induced depressive-like rats, oral treatment with chrysin (5 or 20mg/kg, 28 days), similarly to fluoxetine (10mg/kg, positive control) inhibited the decrease in the time of grooming in the splash test and increase in the immobility time.

Chrysin (5 or 20mg/kg, 28 days), similarly to fluoxetine treatment was also found to inhibit the production of pro-inflammatory cytokines and elevated corticotropin-releasing hormone and adrenocorticotropic hormone in the UCS-induced depressive-like rats.

Where elevated corticotropin-releasing hormone and adrenocorticotropic hormone was associated with patients with depression.


Moreover, Chrysin (5 or 20mg/kg, 28 days), similarly to fluoxetine treatment also attenuated the hormone deficiency such as 5-HT levels in the HP and elevated enzyme and matrixes such as indoleamine-2,3-dioxygenase, caspase 3 and 9 activities in the PFC and HP associated with depression-like symptoms, induced by UCS.

Taken altogether, honey processed bioactive compound chrysin may be considered a functional remedy for the treatment of depression, pending the confirmation of larger sample size and multicenter human study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Chronic unpredictable mild stress decreases BDNF and NGF levels and Na(+),K(+)-ATPase activity in the hippocampus and prefrontal cortex of mice: antidepressant effect of chrysin by Filho CB1, Jesse CR2, Donato F1, Giacomeli R1, Del Fabbro L1, da Silva Antunes M1, de Gomes MG1, Goes AT1, Boeira SP1, Prigol M1, Souza LC. (PubMed)
(2) Neurochemical factors associated with the antidepressant-like effect of flavonoid chrysin in chronically stressed mice by Filho CB1, Jesse CR2, Donato F1, Del Fabbro L1, de Gomes MG1, Goes ATR1, Souza LC1, Giacomeli R1, Antunes M1, Luchese C3, Roman SS4, Boeira SP. (PubMed)

Beta-Sitosterol Processes Anti-Asthmatic Activity

By Kyle J. Norton

Respiratory Disease is a medical condition, that affects the breathing organ and tissues including inflammatory lung disease, obstructive lung diseases, restrictive lung diseases, respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc.

The lung is a vital organ of the human being, located near the backbone on either side of the heart with functions of inhaling oxygen from the air and then transporting them to the bloodstream to nourish the body cells' needs and exhaling carbon dioxide from the bloodstream.

Lung diseases are medical conditions, affecting the upper respiratory tract, trachea, bronchi, bronchioles, alveoli, pleura and pleural cavity, and the nerves and muscles of breathing.

People with lung diseases have breathing problems, preventing them to get enough oxygen for the body's needs.

According to statistics from the World Health Organization, respiratory diseases are the leading causes of death and disability in the world. Chronic obstructive pulmonary disease (COPD) and asthma are 2 of the most common respiratory disease in the world, affecting 65 million and 334 million people, respectively.

3 million people die from the chronic obstructive pulmonary disease (COPD) each year, making it the third leading cause of death worldwide. And 14% of 334 million people who suffer from asthma are children.

Long-term smoking is considered one of the leading risk factors for lung diseases. Other risk factors associated with the onset of lung diseases include radon, asbestos, second-hand smoke, and air pollution.

Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. 

The disease affects people of all ages, and mostly starts during childhood. 

Beta-Sitosterol is a phytochemical in the class of phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, and buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of inflammatory diseases, researchers examined the anti-inflammatory effect and the underlying molecular mechanisms of β-sitosteryl-3-O-β-glucopyranoside in lipopolysaccharide (LPS)-induced RAW 264.7 cells.

According to the chemical analysis, β-sitosteryl-3-O-β-glucopyranoside inhibited the production of nitric oxide (NO) and PGE₂ along with the expression of iNOS and COX-2 associated with the activation of pro-inflammatory cytokines in LPS-stimulated RAW264.7 cells.

Furthermore, β-sitosteryl-3-O-β-glucopyranoside reduced the release of pro-inflammatory cytokines, such as TNF-α, IL-1β, and IL-6.

Moreover, β-sitosteryl-3-O-β-glucopyranoside inhibited the NF-κB activation induced by LPS, which was associated with the abrogation of IκBα degradation and subsequent decreases in nuclear p65 levels, one of the five components that form the NF-κB.

Collectively, researchers wrote, " the β-sitosteryl-3-O-β-glucopyranoside inhibited NO and pro-inflammatory productions by down-regulating the gene expression of pro-inflammatory mediators via the negative regulation of the NF-кB pathway in LPS-stimulated RAW 264.7 cells".

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of inflammatory diseases such as asthma, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antihistaminic and antiallergic actions of extracts of Solanum nigrum berries: possible role in the treatment of asthma by Nirmal SA1, Patel AP, Bhawar SB, Pattan SR. (PubMed)
(2) β-sitosteryl-3-O-β-glucopyranoside isolated from the bark of Sorbus commixta ameliorates pro-inflammatory mediators in RAW 264.7 macrophages by Yang G1, An HJ. (PubMed)
(3) Asthma (Respiratory Disease) – The Risk factors by Kyle J. Norton

Phytochemical Beta-Sitosterol Processes Antimetastatic Property

By Kyle J. Norton

Cancer is a class of diseases characterized by irregular cell growth on the body tissue, due to the alternation of cell DNA.

Most cases of cancer start in the cell on the surface of the inner lining tissue and do not exert any symptoms at the early stage.

At the later stage, cancer cells can also travel a distance away from the original site to affect other healthy tissue and organs,.

Metastasis is the process to induce the development of secondary malignant growths at a distance from primary cancer.

Metastatic cancer also shares the characteristics of primary cancer. Breast cancer that spreads to the lung is called metastatic breast cancer, not lung cancer.

According to statistics, in 2018, approximately over1,700,000 cases of cancer were diagnosed worldwide. The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Believe it or not, some metastatic cancer may have an unknown primary origin or CUP, secondary cancer without a primary cancer site.

Anti-metastasis is an action in which substances are used including herbal medicine to stop the cancer cell to infect other healthy tissues a distance away from the primary tumor.

Most cancer drugs used in conventional medicine with the ability to block the migration of cancer cells are considered to process antimetastatic activity.

In other words, anti-metastasis drugs are agents that interfere with all modes of cancer cell migration, compared to conventional cytostatic drugs involved in blocking cancer cell proliferation.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belonging to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention of cancer spreading to other organs and tissues, researchers examined synthesized redox-sensitive heparin-β-sitosterol micelles antimetastatic activity using Doxorubicin (Dox) encapsulated via the dialysis method.

According to the chemical analysis, approximately 89% and 52% of Dox were released after 48h in the presence and absence of reduced glutathione.

bHSC-treated HeLa cells showed a strong hemocompatibility to improve the interaction of bHSC with the cancer cells and antimetastatic effects against cancer cell proliferation and spreading without inducing side effects of toxicity.

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention of cancer cell spreading, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Synthesis and characterization of redox-sensitive heparin-β-sitosterol micelles: Their application as carriers for the pharmaceutical agent, doxorubicin, and investigation of their antimetastatic activities in vitro by Debele TA1, Mekuria SL1, Tsai HC. (PubMed)

#Antioxidant Lycopene Inhibits Parameters that Induces Post Myocardial Infarction Complications, Scientists Suggest

By Kyle J. Norton

Acute brain infarction is a severe medical emergency characterized by the obstruction of the blood supply to the brain, causing local death of the neurons in the brain. Prompt treatment can minimize brain damage and potential complications.

The occurrence and extent of brain infarction are associated with three basic factors, including the site of arterial occlusion, the rapidity of arterial occlusion, and the presence or absence of collateral circulation.

In other words, brain infarction can be classified into myocardial infarction due to plaque rupture and myocardial oxygen supply-demand imbalance secondary to other acute illnesses.

The exact causes of a blood clot to induce acute brain infarction are unknown. However, trouble with speaking and understanding, confusion, sudden numbness, weakness or paralysis in your face, arm, or leg, headache, and trouble with walking are some of the most common symptoms found in patients with post-myocardial infarction.

Depending on the severity of the acute infarction, in serious cases, patients may also experience symptoms, paralysis of the face, arm, or leg, and trouble with seeing in one or both eyes.

Although, there are many factors associated with the risk of acute infarction. some researchers suggested aging may have a strong and negative implication on acute infarction.

Dr. Amelia Carro, the lead scientist wrote, "Data from 163,140 hospital admissions of Medicare beneficiaries age > or =65 years between 1994 and 1996 with AMI at U.S. hospitals were evaluated for differences in clinical characteristics and mortality across five age-based strata (in years): 65 to 69, 70 to 74, 75 to 79, 80 to 84 and > or =85".

And, "Our data indicate significant age-associated differences in clinical characteristics in elderly patients with AMI, which account for some of the age-associated differences in mortality".


Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas.

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a natural compound for the treatment o post-heart attack, researchers examined supplementation on cardiac remodeling after myocardial infarction (MI).

The study included male Wistar rats assigned randomly into four groups: the sham group (animals that underwent simulated surgery) that received a standard chow (S; n=18), the infarcted group that received a standard chow (MI; n=13), the infarcted group supplemented with lycopene (1 mg of lycopene/kg body weight/day) (MIL; n=16) and the infarcted group supplemented with tomato (MIT; n=16).

At the end of 3 months of the experiment, based on the assay analysis, researchers found that* The groups MIL and MIT showed decreased interstitial fibrosis induced by infarction.

* Tomato-treated group attenuated the hypertrophy induced by MI.

* Lycopene reduced the expression of proteins and pathways associated with pro-inflammatory cytokines such as TGF-β1, NF-κB, and TNF-α respectively, collagen I, and collagen III associated with the initiation of fibrous tissues.

* Most importantly, lycopene also ameliorated the level of ventricular remodeling post-MI.

Based on the findings, researchers said, "Lycopene may inhibit the NF-κB signaling pathway thereby reducing the inflammatory response and cardiomyocyte apoptosis post-MI, which could be a key mechanism of lycopene in attenuating ventricular remodeling".

Taken altogether, lycopene found in tomatoes may be considered supplements for the treatment of cardio-remodeling in post-myocardial infarction, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose and acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tomato (Lycopersicon esculentum) or lycopene supplementation attenuates ventricular remodeling after myocardial infarction through different mechanistic pathways by Pereira BLB1, Reis PP2, Severino FE3, Felix TF4, Braz MG5, Nogueira FR6, Silva RAC7, Cardoso AC8, Lourenço MAM9, Figueiredo AM10, Chiuso-Minicucci F11, Azevedo PS12, Polegato BF13, Okoshi K14, Fernandes AAH15, Paiva SAR16, Zornoff LAM17, Minicucci MF. (PubMed)
(2) Lycopene attenuates inflammation and apoptosis in post-myocardial infarctionremodeling by inhibiting the nuclear factor-κB signaling pathway by He Q1, Zhou W1, Xiong C1, Tan G1, Chen M. (PubMed)
(3) Acute myocardial infarction in the elderly: differences by age by Mehta RH1, Rathore SS, Radford MJ, Wang Y, Wang Y, Krumholz HM. (PubMed)