Beta-Sitosterol Processes Anti-Asthmatic Activity

By Kyle J. Norton

Respiratory Disease is a medical condition, that affects the breathing organ and tissues including inflammatory lung disease, obstructive lung diseases, restrictive lung diseases, respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc.

The lung is a vital organ of the human being, located near the backbone on either side of the heart with functions of inhaling oxygen from the air and then transporting them to the bloodstream to nourish the body cells' needs and exhaling carbon dioxide from the bloodstream.

Lung diseases are medical conditions, affecting the upper respiratory tract, trachea, bronchi, bronchioles, alveoli, pleura and pleural cavity, and the nerves and muscles of breathing.

People with lung diseases have breathing problems, preventing them to get enough oxygen for the body's needs.

According to statistics from the World Health Organization, respiratory diseases are the leading causes of death and disability in the world. Chronic obstructive pulmonary disease (COPD) and asthma are 2 of the most common respiratory disease in the world, affecting 65 million and 334 million people, respectively.

3 million people die from the chronic obstructive pulmonary disease (COPD) each year, making it the third leading cause of death worldwide. And 14% of 334 million people who suffer from asthma are children.

Long-term smoking is considered one of the leading risk factors for lung diseases. Other risk factors associated with the onset of lung diseases include radon, asbestos, second-hand smoke, and air pollution.

Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. 

The disease affects people of all ages, and mostly starts during childhood. 

Beta-Sitosterol is a phytochemical in the class of phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, and buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of inflammatory diseases, researchers examined the anti-inflammatory effect and the underlying molecular mechanisms of β-sitosteryl-3-O-β-glucopyranoside in lipopolysaccharide (LPS)-induced RAW 264.7 cells.

According to the chemical analysis, β-sitosteryl-3-O-β-glucopyranoside inhibited the production of nitric oxide (NO) and PGE₂ along with the expression of iNOS and COX-2 associated with the activation of pro-inflammatory cytokines in LPS-stimulated RAW264.7 cells.

Furthermore, β-sitosteryl-3-O-β-glucopyranoside reduced the release of pro-inflammatory cytokines, such as TNF-α, IL-1β, and IL-6.

Moreover, β-sitosteryl-3-O-β-glucopyranoside inhibited the NF-κB activation induced by LPS, which was associated with the abrogation of IκBα degradation and subsequent decreases in nuclear p65 levels, one of the five components that form the NF-κB.

Collectively, researchers wrote, " the β-sitosteryl-3-O-β-glucopyranoside inhibited NO and pro-inflammatory productions by down-regulating the gene expression of pro-inflammatory mediators via the negative regulation of the NF-кB pathway in LPS-stimulated RAW 264.7 cells".

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of inflammatory diseases such as asthma, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antihistaminic and antiallergic actions of extracts of Solanum nigrum berries: possible role in the treatment of asthma by Nirmal SA1, Patel AP, Bhawar SB, Pattan SR. (PubMed)
(2) β-sitosteryl-3-O-β-glucopyranoside isolated from the bark of Sorbus commixta ameliorates pro-inflammatory mediators in RAW 264.7 macrophages by Yang G1, An HJ. (PubMed)
(3) Asthma (Respiratory Disease) – The Risk factors by Kyle J. Norton