Friday, 7 October 2022

Phytochemical Beta-Sitosterol Processes Antimetastatic Property

By Kyle J. Norton

Cancer is a class of diseases characterized by irregular cell growth on the body tissue, due to the alternation of cell DNA.

Most cases of cancer start in the cell on the surface of the inner lining tissue and do not exert any symptoms at the early stage.

At the later stage, cancer cells can also travel a distance away from the original site to affect other healthy tissue and organs,.

Metastasis is the process to induce the development of secondary malignant growths at a distance from primary cancer.

Metastatic cancer also shares the characteristics of primary cancer. Breast cancer that spreads to the lung is called metastatic breast cancer, not lung cancer.

According to statistics, in 2018, approximately over1,700,000 cases of cancer were diagnosed worldwide. The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Believe it or not, some metastatic cancer may have an unknown primary origin or CUP, secondary cancer without a primary cancer site.

Anti-metastasis is an action in which substances are used including herbal medicine to stop the cancer cell to infect other healthy tissues a distance away from the primary tumor.

Most cancer drugs used in conventional medicine with the ability to block the migration of cancer cells are considered to process antimetastatic activity.

In other words, anti-metastasis drugs are agents that interfere with all modes of cancer cell migration, compared to conventional cytostatic drugs involved in blocking cancer cell proliferation.


Beta-Sitosterol is a phytochemical in the class of Phytosterols, belonging to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention of cancer spreading to other organs and tissues, researchers examined synthesized redox-sensitive heparin-β-sitosterol micelles antimetastatic activity using Doxorubicin (Dox) encapsulated via the dialysis method.

According to the chemical analysis, approximately 89% and 52% of Dox were released after 48h in the presence and absence of reduced glutathione.

bHSC-treated HeLa cells showed a strong hemocompatibility to improve the interaction of bHSC with the cancer cells and antimetastatic effects against cancer cell proliferation and spreading without inducing side effects of toxicity.

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention of cancer cell spreading, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Synthesis and characterization of redox-sensitive heparin-β-sitosterol micelles: Their application as carriers for the pharmaceutical agent, doxorubicin, and investigation of their antimetastatic activities in vitro by Debele TA1, Mekuria SL1, Tsai HC. (PubMed)

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