Herbal Angelica Processes Anti- Cancer Activity in Vitro

By Kyle J. Norton

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Lung, breast, prostate, and colorectal cancers are the most common cancer in the US.

Free radicals are unstable atoms with a single electron in the outer ring. Therefore, in order to remain stable. free radicals are ready to donate or intercept an electron from other atoms, leading to a chain of oxidative reactions that can not be stopped until all electrons are paired or inhibited by antioxidants.

Oxidative stress is an imbalanced ratio of free radicals and antioxidants in the body. It is caused by either overexpression of free radicals or depletion of antioxidants in the body.

Believe it or not. overexpression of free radicals for a long period of time or oxidative stress can cause cells and lipid damage, leading to alteration of cell DNA, a leading cause of cancer.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a natural compound for the treatment of diseases associated with DNA alternation, the researchers examined the effects of Angelica n-Butylidenephthalide (BP) anti-cancer activity.

According to the assays that the results from the application of riboflavin-5'-phosphate (RFMP) immobilized iron oxide magnetic nanoparticles (Fe3O4 MNPs) as carriers for BP to treat cancer cell lines overexpressed riboflavin receptors on their cell membrane-derived from liver, prostate, breast, cancer cells
* BP treatment. showed a strong sensitivity to the tested cell lines.

* BP-binding free riboflavin-5'-phosphate (RFMP) on MNPs to target these model cells during the period of treatment by readily released on target cancer cells.

* Fe3O4@RFMP MNPs immobilized with BP released free-form BP at a similar amount for the inhibition of cancer cells, with no apparent harmful effects on non-target cells.

* BP-Fe3O4@RFMP MNPs upregulated the level of cysteine-aspartic acid protease 3 (caspase 3) associated with cancer cell apoptosis.

Taken altogether, Herbal Angelica may be sued for the treatment of cancer, pending to larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Riboflavin immobilized Fe3O4 magnetic nanoparticles carried with n-butylidenephthalide as targeting-based anticancer agents by Wu CY1, Chen YC. (PubMed)

Betanin Isolated From Beetroot, a Potential and Natural Plant-Based Antioxidant that Prevents Oxidative Stress Developing

By Kyle J. Norton

Oxidative stress is a condition caused by an imbalance of the ratio of free radicals and antioxidants in the body.

In other words, oxidative stress is either caused by overexpression of free radicals or depletion of antioxidant enzymes in the body.

Some researchers suggested that oxidative stress may also arise due to the chain reaction of free radicals in which free radicals donate or intercept an electron from other stable molecules.

Long-term oxidative stress present in the body can cause protein and lipid damage and alternation of cell DNA, leading to the onset of chronic diseases, including cardiovascular disease, diabetes, and cancer.

More precisely, exogenous factors, such as cigarette smoke, and endogenous factors, such as the oxidative burst from activated macrophages are some of the factors involved in the risk of oxidative stress.

The Liver Pathophysiology, 2017 in the explanation of the cause of oxidative stress, wrote, " (1) the presence of xenobiotics, (2) the activation of the immune system in response to invading microorganisms (inflammation), and (3) radiation, which makes oxidative stress a common denominator of toxicity or stress".

In other words, oxidative stress may be preventable by following a diet rich in antioxidants such as a diet with higher fruits and vegetable consumption accompanied by moderate exercise and reducing intake of saturated and trans fat and processed foods.

Betanin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a potential compound for the prevention of diseases associated with oxidative stress, researchers examined the effects of natural pigment betanin on oxidative stress in the kidney of paraquat-treated rats.

Paraquat injected intraperitoneally induce renal damage rats were randomly divided into four groups: a control group, a paraquat group, and two paraquat groups that were treated with betanin at 25 and 100 mg/kg/d three days before and two days after paraquat administration.

Betanin-treated rats showed strong activity in alleviating the paraquat-incurred acute kidney injury, observed by the improvement, reduced serum and urine markers that indicate a kidney injury.

Betanin also decreased oxidative stress elicited by paraquat by increasing the expression of antioxidant enzymes produced by the host accompanied by inhibiting the levels of free radicals.

These results suggested that betanin protects the tested rats against kidney damage due to oxidative stress in the induction of chronic inflammation.

In streptozotocin (STZ) induced diabetes (DN) in rats, researchers examined the betanin anti-fibrotic mechanisms in rat kidneys.

Betanin at a dose of 25, 50, and 100mg/kg/day and lisinopril (5mg/kg/day, reference compound) orally administered for 8 weeks after the induction of DN, not only significantly inhibited proteinuria, blood glucose, serum creatinine and blood urea nitrogen (BUN) levels involved in kidney injury, but also restored antioxidant enzyme activities in kidney tissue.

Additionally, betanin treatment also protected kidney integrity by reducing the glomerular surface area, glomerulosclerosis, and tubulointerstitial fibrosis.

In other words, betanin demonstrated the kidney protective activity against streptozotocin (STZ) induced diabetes (DN) in rats through regulation of transforming growth factor-beta (TGF-β) in facilitating the anti-oxidative and anti-inflammatory activity.


Taken altogether, betanin may be considered supplements for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of a larger sample size and multicenter human study.

Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Betanin attenuates oxidative stress and inflammatory reaction in the kidney of a paraquat-treated rat by Tan D1, Wang Y2, Bai B1, Yang X2, Han J. (PubMed)
(2) Betanin, isolated from fruits of Opuntia elatior Mill attenuates renal fibrosis in diabetic rats through regulating oxidative stress and TGF-β pathway by Sutariya B1, Saraf M2. (PubMed)
(3) Oxidative Stress, From Liver Pathophysiology, 2017. (Science Direct)

Phytochemical 3,3'-Diindolylmethane Isolated From Cruciferous Vegetables Inhibit Parameters Associated with the Risk of Hyperglycemia

By Kyle J. Norton

Hyperglycemia is a condition of abnormally high blood sugar in the bloodstream associated with diabetic complications in patients with type 2 diabetes.

In order words, hyperglycemia is a result of the body which isn't properly using or doesn't make the hormone insulin.

Hyperglycemia is also considered a hallmark of patients with type 2 diabetes. Another hallmark is insulin resistance.

The condition occurs mostly due to poor control and management in patients with diabetes such as
a poor diet, physical inactivity choices, symptoms of medicines intake.


Some patients with diabetes also experience symptoms of hyperglycemia due to skipping or not taking enough glucose-lowering medication.


The most common symptoms of hyperglycemia are frequent urination, increased thirst, blurred vision, persistent fatigue, and headache.

If you are having some of the aforementioned symptoms, you may have hyperglycemia. Please make sure you check with your doctor to prevent longer-term untreated complications.

According to epidemiological studies, untreated or long-term persistently hyperglycemia in patients with diabetes has been found to induce serious symptoms such as shortness of breath, confusion, and coma.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

With an aim to find a natural ingredient for the treatment of hyperglycemia in patients with type 2 diabetes, researchers examined the effect of the nutritive phytochemicals, indole-3-carbinol (I3C) and its metabolite, 3, 3'- diindolylmethane (DIM) on oxidative stress developed in type 2 diabetes mellitus (T2DM).

The study is carried out on the genetically modified mouse (C57BL/6J mice) similar to those of metabolic abnormalities of the human disease after the administration of a high-fat diet (HFD).

Injection of DIM and I3C positively modulated the glucose, insulin, and hemoglobin (Hb), glycated hemoglobin (HbA1c) level, an indication of the hyperglycemically modulatory activities in the tested HFD mice.

Compared to the HFD group, treatment groups showed a decrease in the levels of thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides (LOOH), conjugated dienes (CD associated with oxidative stress in lipid peroxidation.

Furthermore, DIM and I3C also improved the antioxidant enzymes produced by the host observed by the increasing SOD, CAT, GPx levels in the erythrocyte, liver, kidney, and heart.

Levels of free radical scavengers such as vitamin C, vitamin E, and GSH levels are also increased in the plasma, liver, kidney, and heart in diabetic mice.

In other words, DIM and I3C protected diabetic mice against diabetics complications by modulating blood glucose and lipid by balancing the ratio of free radicals and antioxidants in the tested subjects.

Based on the finding, researchers wrote in the final report, "the antioxidant-scavenging action was accelerated in mice treated with DIM than the I3C treatment group which was comparable with the standard drug metformin".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of hyperglycemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Attenuation of hyperglycemia-mediated oxidative stress by indole-3-carbinol and its metabolite 3, 3'- diindolylmethane in C57BL/6J mice by Jayakumar P1, Pugalendi KV, Sankaran M. (PubMed)

Plant-Based Alliin Isolated From Garlic and Onion May Process Anti Liver Cancer Property, Researchers Say

By Kyle J. Norton

Liver cancer is a medical condition caused by irregular cell growth in the liver tissue.

According to the statistics assessed by the cancer experts, in 2019, approximately 42,030 adults (29,480 men and 12,550 women) in the United States will be diagnosed with primary liver cancer.

Believe it or not, since 1980, the incidence of liver cancer has tripled. Between 2006 and 2015, the number of people diagnosed with the disease increased by approximately 3% annually.

The most common preventable causes of liver cancer are excessive alcohol drinking over time, chronic infection by hepatitis B and C, and cirrhosis.

Types of liver cancer include

* Hepatocellular carcinoma, the most common type of liver cancer accounting for 75 percent of all cases.

* Cholangiocarcinoma is a cancer of the bile duct, which is the small, tube-like bile ducts in the liver that carry bile to the gallbladder to help with digestion.


* Liver Angiosarcoma is a rare form of liver cancer that develops quickly and

* Hepatoblastoma also is a rare type of liver cancer found in children, particularly in those under age 3.


The most common symptoms of liver cancer are upper abdominal pain., abdominal swelling, jaundice and white, chalky stools, accompanied by general symptoms shared by other types of cancer including unintended weight loss, gastrointestinal discomfort, loss of appetite, and persistent fatigue.

If you have experienced some of the aforementioned symptoms with no signs of receding, please make sure that you check with your doctor to rule out the possibility.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find a potential ingredient for the treatment of liver cancer with little or no side effects, researchers in the cancer team at the Institut National de la Recherche Agronomique examined the increasing fertilization of soil resulted in an increased alliin content of the powders on liver cancer animal model.

According to the results, garlic powders administered to rats for 2 weeks (5% of the diet), administration of the different garlic powders demonstrated a 35-60% reduction in DNA damage induced by N-nitrosodimethylamine (NDMA) in rat liver.

In examining the increased alliin content of the garlic powder, researchers found that the presence of alliin was associated strongly with a proportional decrease in NDMA induced DNA alteration.


Believe it or not, the increased levels of Alliin in the garlic powder content did not have an additional effect on DNA damage induced by aflatoxin B1 in the liver or by 1,2-dimethylhydrazine in the colon, compared to the efficacy in the liver.

In other words, garlic powders regardless of the levels of alliin did not modify the genotoxic activity which is the direct-acting carcinogen methyl nitrosourea in the colon.

Taken altogether, alliin may be considered a supplement for the prevention and treatment of liver cancer, depending on the confirmation of the larger sample size and multicenter human study.



Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibition of carcinogen-induced DNA damage in rat liver and colon by garlic powders with varying alliin content by Singh V1, Belloir C, Siess MH, Le Bon AM. (PubMed)
(2) Effects of garlic powders with varying alliin contents on hepatic drug metabolizing enzymes in rats by Le Bon AM1, Vernevaut MF, Guenot L, Kahane R, Auger J, Arnault I, Haffner T, Siess MH.(PubMed)

Onion's Quercetin Inhibits Invasive Osteosarcoma in Vitro, According to Study

By Kyle J. Norton

Osteosarcoma is a type of bone cancer found mostly in teenagers and people over age 60.

Most cases of osteosarcoma are associated with genetic syndromes. In other words, Osteosarcoma is associated with a genetic preposition inherited from the parent.

Dr. James J. Morrow wrote, "Osteosarcoma is the most common primary malignancy of bone, typically presenting in the first or second decade of life".

And, " Increased risk of osteosarcoma is associated with a number of well-defined genetic syndromes: hereditary retinoblastoma (germline mutation of the Rb gene), Li-Fraumeni syndrome (germline mutation of the p53 gene), Bloom syndrome (germline mutation of the RECQL2 gene), Werner syndrome (germline mutation of the RECQL3 gene), and Rothmund-Thomson syndrome (germline mutation of the RECQL4 gene)".

The exact causes of osteosarcoma are unidentified. However, epidemiologically, besides gene expression, an unhealthy lifestyle such as body weight, physical activity, diet, and tobacco, gender, age, height, ethnicity, and exposure to bone radiation are also some prevalent factors found in patients with the disease.

According to the statistic, in the US, osteosarcoma is rare and approximately 900 new cases of osteosarcoma are diagnosed each year. Children and teens are younger than 20 accounts for half of the numbers.

The overall 5-year survival rate for children and teens with osteosarcoma is 70%. If cancer has spread to the lung, the 5-year survival rate is only 40% comapred to localized cancer between 60% to 80%.


Conventionally, Most cases of osteosarcoma are o treated with a combination of surgery, chemotherapy, and radiation therapy.


In patients with high-grade tumors, before surgery, neo-adjuvant therapy may be necessary to shrink the tumor.

The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.

On finding a potent ingredient for the treatment of osteosarcoma researchers examined the effects of quercetin on proliferation, migration, and invasion in U2OS and Saos-2 cells.

According to the tested analysis, quercetin (20, 40, 60, 80, or 100 μM) for 48 h, incubation with U2OS and Saos-2 cells showed a significant reduction of cancer cell viability, in a dose-dependent manner.

Cell adhesion, invasion, and migration of the tested cell lines were also significantly inhibited by the application of quercetin only at higher concentrations.

Furthermore, the expressions of pro-apoptotic matrixes were increased accompanied by the decrease of anti-apoptotic proteins.

Moreover, gene PTHR1 associated with tumor proliferation was also decreased by quercetin.

More precisely, PTHR1 expression in U2OS cells was reduced by 0.18-, and 0.41-fold at 80, and 100 μM, respectively, whereas 0.15 and 0.38 folds in Saos-2 cells.

In other words, by inhibiting the expression of PTHR, quercetin inhibited proliferation and invasion of the tested cell lines.

Based on the results, researchers said, "quercetin reduced human metastatic osteosarcoma cell invasion, adhesion, proliferation, and migration by inhibiting PTHR1."

Taken altogether, onion may be considered a remedy for the prevention and treatment of metastatic osteosarcoma, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Quercetin suppresses the proliferation and metastasis of metastatic osteosarcoma cells by inhibiting parathyroid hormone receptor 1 by Li S1, Pei Y1, Wang W1, Liu F1, Zheng K2, Zhang X.
(PubMed)
(2) Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-κB and matrix metalloproteinase-2/-9 signaling pathways by Lai WW1, Hsu SC, Chueh FS, Chen YY, Yang JS, Lin JP, Lien JC, Tsai CH, Chung JG. (PubMed)

Cucumber's Cucurbitacin B (CuB) Modulates the Capacity of Gut Microbiota in Vitro and Vivo

By Kyle J. Norton

Gut Microbiota is a community of microorganisms living in our gut. Under normal conditions, the ratio of the gut microbiome composition is balanced.

However, the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle may alternate the ratio by increasing the growth of "bad" bacterias, leading to the development of chronic diseases such as inflammatory bowel disease, obesity, cancer, and autism.

In other words, imbalanced of the gut microbiota may have a strong and negative impact on the immunity, the digestive, fat, and carbohydrate metabolism, and the central nervous system

* In immunity, the balance of the gut microbes showed to stimulate the immune function against inflammatory immune disorders.

* In the digestive system, balanced gut microbes protect the gut against gastrointestinal diseases and non-gastrointestinal diseases. caused by overexpression of bad bacteria.


* In carbohydrate metabolism, gut microbes influence the nutrient extraction from the diet, thus reducing the risk of obesity and obesity complications.

* Neurologically, gut microbiota can control brain insulin signaling and metabolite levels that play a critical role in neurobehaviors.

Out of many prevalent factors that cause the onset of the unbalanced ratio of gut microbiota, some researchers suggested that the Western diet may have negatively influenced to induce overgrowth of bad microorganisms in the gut.

Dr. Marit K. Zinöcker, the lead scientist wrote, "Western diet promotes inflammation that arises from both structural and behavioral changes in the resident microbiome"

And, "The environment created in the gut by ultra-processed foods, a hallmark of the Western diet, is an evolutionarily unique selection ground for microbes that can promote diverse forms of inflammatory disease".


The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural compound that enhances the gut microbiome's composition, researchers compared the effects of carrot, cucumber, and broccoli seed flours extracts with 50% acetone on gut microbiota modulating capacity.

In vitro, all three seed flour extracts enhanced the total number of gut bacteria and altered the abundance of specific bacterial phylum or genus.

In other words, cucumber showed a potential effect to improve the ratio of gut microbiota in the flavor of the "good" bacterias, similar to those of carrot and broccoli.


In J774A.1 cells, cucumber also exerted a similar activity by protecting the microbiota that exhibits anti-inflammatory activity by suppressing LPS induced production of pro-inflammatory cytokines, such as IL-1β and COX-2 mRNA expressions.

Furthermore, in obesity, induced progression of metabolic disorders, especially type 2 diabetes (T2DM), cucumber not only improved IR in obese mice and relieving inflammation in adipose tissue and blood but also enhanced the microbiota composition ratios.

More precisely, cucumber improved the ratio of gut microbiome composition by promoting IR and reducing inflammation.


Taken altogether, cucumber may be used for the improvement of gut microbiota, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Chemical Compositions of Cold-Pressed Broccoli, Carrot, and Cucumber Seed Flours and Their in Vitro Gut Microbiota Modulatory, Anti-inflammatory, and Free Radical Scavenging Properties by Choe U1, Li Y1,2, Gao B2, Yu L1, Wang TTY, Sun J, Chen P, Liu J3, Yu L. (PubMed)
(2) Therapeutic Effect of Cucumis melo L. Extract on Insulin Resistance and the gut microbiome in Lepob/Lepob Mice by Lee D1, Yoo JH1, Lee BC. (PubMed)
(3) The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease by Marit K. Zinöcker1, and Inge A. Lindseth. (PMC)

Cranberry Processes Immune-Modulatory Activity

By Kyle J. Norton

The immune system is the set of cells and their activity against antigens or infectious agents that comprise the body's defense system against diseases.

The immune system does a great job of keeping people healthy and preventing infections. Besides foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.

Active immunity may also be artificially acquired caused by the injection of the vaccine, a substance that contains antigen and passive immunity is an auto-response of the immune system against infection through the production of antigen.

Immunity can also be passive and active, Dr. David Baxter, in the article of "Active and passive immunity, vaccine types, excipients and licensing" wrote, "Active immunity refers to the process of exposing the body to an antigen to generate an adaptive immune response: the response takes days/weeks to develop but may be long-lasting—even lifelong" and " Passive immunity refers to the process of providing IgG antibodies to protect against infection; it gives immediate, but short-lived protection—several weeks to 3 or 4 months at most. Passive immunity is usually classified as natural or acquired".

However, an abnormal immune response such as overactive and underactive may cause a weakened immune system or autoimmune diseases.

Immunomodulatory activity is an action that improves the underactive immune function that is susceptible to the invasion of the foreign microorganism and inhibits the overactive immune system that causes autoimmune diseases.

In other words, the immunomodulatory activity is to modulate the genes involved in immune reactions, or of the neurohormonal system which regulates immune functions and any toxic or immunotoxic effects such as allergic reactions or destruction of immune effectors, that may cause harm to the body or interfere with the body normal function.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of diseases associated with immune compromise, researchers investigated the immunomodulatory effect of KC-1317 (a symbiotic mixture containing Saccharomyces boulardii lysate in a cranberry, colostrum-derived lactoferrin, fragaria,

The human trial included healthy volunteers with years of age ranging from 65-79 years with low natural killer (NK) cell activity,

According to the differentiation, liquid C-1317 showed a strong improvement in NK cell activity.

In other words, the select remedy resulted in immune-modulatory effects on the treatment group, compared to placebo at the end of 2 months.

Based on the findings, researchers said, " Although preliminary, these beneficial immune-modulatory effects of KC-1317 in aged individuals might indicate its employment within a wider age-management strategy".

Taken altogether, cranberry combined with other herbal medicine may be considered immune-modulatory remedy, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Gut-targeted immunonutrition boosting natural killer cell activity using Saccharomyces boulardii lysates in immuno-compromised healthy elderly subjects by Naito Y1, Marotta F, Kantah MK, Zerbinati N, Kushugulova A, Zhumadilov Z, Illuzzi N, Sapienza C, Takadanohara H, Kobayashi R, Catanzaro R. (PubMed)
(2) Active and passive immunity, vaccine types, excipients and licensing by David Baxter(Oxford Academic)