Cranberry, the Antioxidants Functional Fruit

By Kyle J. Norton

Free radicals are highly unstable atoms. Internally, free radicals are produced by our body cell metabolism. Externally, free radical can enter our body from the environment sources, such as the air we breathe, the food we eat and the water we drink.

In other words, any chemicals compounds or molecules which process an oxygen atom can be free radicals in a chemical reaction with other atoms.

According to epidemiological studies, free radicals are dangerous to human health in excessive amounts. Overexpression of free radicals induced oxidative stress has been found to damage the lipid, and protein and induce the alternation of healthy cell DNA.

Antioxidants are stable atoms that inhibit oxidation induced by free radicals.

Out of all damages caused by overexpression of free radicals, some researchers suggested that lipid peroxidation induced by free radicals has a strong implication in the pathogenesis of various disorders and diseases.

Oxidative stress can either be caused by overexpression of free radicals or depletion of antioxidant enzymes produced by the host. The condition has been found to induce cardiovascular disease and type 2 diabetes.

In a healthy person, antioxidants produced by the body are more than enough to counter the expression of free radicals. However, in people with a weakened immune system, the intake of dietary antioxidants regularly can be helpful.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia.

 Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of diseases associated with oxidative stress, researchers examined the effect of cranberry (V. macrocarpon) antioxidant activity.

According to studies, 

* Vaccinium oxycoccos fruit as a whole group is a valuable source of antioxidants and other biologically active substances.

* European cranberry fruit processed a strong antioxidant property due to rich in polyphenolic compounds anthocyanins (12.4–207.3 mg/100 g fw), proanthocyanins (1.5–5.3 mg/100 g fw), and flavonols, especially quercetin (0.52–15.4 mg/100 g fw).

* Small cranberry showed a significant antioxidant effect against various biological protection including urinary tract protection (proanthocyanidins), antibacterial and antifungal properties (quercetin, proanthocyanidins, anthocyanins), cardioprotective (proanthocyanidins) and anticancer activities (proanthocyanidins).

Based on the findings, researchers said, "Taking into account various beneficial effects of small cranberries on human health, also in folk medicine, the consumption of these fruits and their products is widely recommended.".

Taken altogether, cranberry may be considered a remedy for the enhancing antioxidant activity, pending to the confirmation of the larger sample size and multicenter human study.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bioactive Compounds, Antioxidant Activity, and Biological Effects of European Cranberry (Vaccinium oxycoccos) by Tunde Jurikova,1 Sona Skrovankova,2 Jiri Mlcek,2,* Stefan Balla,1 and Lukas Snopek. (PMC)

Cabbage Kills Pancreatic Cancer Cells in Vitro

By Kyle J. Norton

The pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen.

By secreting pancreatic juice to the small intestine, the pancreas breaks down carbohydrates, proteins, and lipids. Traditional Chinese medicine views the pancreas as a vital organ that is responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our bodies.

The pancreas plays a major role in regulating blood glucose levels by producing insulin.

Type 1 diabetes occurs when the pancreas does not make enough or any insulin. Type 2 diabetes develops when the body cannot use insulin correctly.

Pancreatic cancer is a chronic condition characterized by cell growth irregularly in the tissues of the pancreas.

According to statistics, every year, approximately, over 55,000 adults in the United States are diagnosed with pancreatic cancer, accounting for 3% of all cancers and 7% of all cancer deaths.

The survival rate of pancreatic cancer even diagnosed early is very low compared to other types of cancer. The 5-year survival rate at stage IA pancreatic cancer is only14%.

The most common risk factors of pancreatic cancer are similar to those of common cancers, including age, family history, gender, ethnicity, smoking, being overweight or obesity and certain medical conditions such as diabetes.

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem of which is crowded a mass of leaves, usually green but in some varieties, it may be red or purplish.

With an aim to find natural food in the prevention and treatment of tumors, researchers investigated the anticancer effects of kimchi prepared by the standard Baechu cabbage and Amtak Baechu cabbage.

4 different kimchi samples that were prepared for this study: (1) the standard Baechu cabbage and dry salt treatment method (SK-D); (2) the Amtak Baechu cabbage and dry salt treatment method (AK-D); (3) the standard Baechu cabbage and brine solution treatment method (SK-B); and (4) the Amtak Baechu cabbage and brine solution treatment method (AK-B).

In human pancreas cancer cells (Capan-2) and human liver cancer cells (HepG2), both cancer cells exposed to AK-D and AK-B showed a significant increase in cell growth inhibition, compared yo SK-D and SK-B (p < 0.05).

At 2.0 mg/mL, the inhibition of Capan-2 cells was more than doubled after treatment with AK-B and AK-D compared with SK-B and SK-D, but was only 1.2 times in HepG2 cells.

AK-D and AK-B treatment exhibited apoptosis and cell cycle arrest by a significant increase of p21 levels associated with cell cycle regulation.

AK-B exerted a higher cytotoxic activity compared with AK-D and the anticancer effects were more apparent in Capan-2 cells than in the HepG2 cells.

Based on the results, researchers wrote, "...kimchi made with Amtak Baechu cabbage and treated with brine solution (AK-B) had a superior anticancer potential against both types of cancer cells, with the effects being greater in pancreatic cancer cells compared with liver cancer cells".

Taken altogether, kimchi made with Amtak Baechu cabbage may be used for the prevention and treatment of pancreatic cancer, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Beneficial Outcomes of Kimchi Prepared with Amtak Baechu Cabbage and Salting in Brine Solution: Anticancer Effects in Pancreatic and Hepatic Cancer Cells by Song GH1, Park ES1, Lee SM1, Park DB2, Park KY. (PubMed)

Common Fig or Fig Kills the Melanoma Cells in Vitro

By Kyle J. Norton

Skin is the largest organ in the body with function to protect the internal organs and tissues against foreign organisms infection, leading organs and tissue injury and damage.

It also is the third organ behind the liver and kidney to eliminate body toxins if the first 2 fails to cleanse them all.

What are the exact causes of skin damage? Some researchers suggested that long-term exposure to the sun is the most common cause of skin damage. UV rays can damage the DNA of skin cells, affecting the normal skin cell growth. UV rays have been linked to the early onset of skin cancer, epidemiologically.

Skin melanoma is a skin cancer characterized by the alternation of the pigment-containing cells known as melanocytes. However, in rare cases, melanoma can also occur in the mouth, intestines, or eye.

The 4 most common types of skin melanoma include
* Superficial spreading melanoma, the type of cancer has a tendency to spread grow outward and spread across the surface of the skin, accounted for 70% of all melanoma skin cancer.

* Nodular melanoma normally grows down into the skin and has a tendency to spread more quickly than other types of melanoma skin cancer.

* Lentigo malignant melanoma, most common in the older population, making up approximately 15% of all melanoma skin cancer.

* Acral lentiginous melanoma, most common in people with darker skin. Cancer first moves outward before spreading deeper into the skin.

The causes of melanoma skin cancer are associated with the alternation of the pigment cells in the skin.

However, according to the epidemiological studies, genetic mutation inherited from the parent, exposure to the environmental toxins and sun UV rays are the most common causes associated with the increased risk of melanoma skin cancer.

According to the statistic, melanoma skin cancer is increasing and anticipated to continue to rise. In the United States, approximately 70,230 new cases of melanoma were diagnosed, causing the death of 8,790.

Fig is a species of F. Carica, belonging to the family Moraceae. It is a deciduous shrub, native to Southeast Asia. The tree can grow to a height of 33 ft and the fruit can be as large as 2.0 inches.

On finding natural compounds for the treatment of skin diseases, researchers examined the latex of fig fruit (Ficus carica) free radical-scavenging activity on 1,1-diphenyl-2 picrylhydrazyl (DPPH) and its phototoxicity on A375 human melanoma cells.

According to the tested differentiation.
* The latex obtained from the fruits of Ficus carica cv. Dottato showed the best antiradical activity with an IC50 value of 0.05 mg/ml

* Furthermore, the latex obtained from the leaves demonstrated the best antiproliferative activity with an IC50 value of 1.5 μg/ml on the human tumor cell line A375 (melanoma) after irradiation at a specific UVA dose (1.08 J/cm2).

* More importantly, the application exerted no cytotoxic effect on healthy control cells.

Based on the findings, researchers said, "comparing F. carica latex of leaves and fruits,... Plant-derived natural products have long been and will continue to be an important source for anticancer drug development".

Taken altogether, common fig or fig (Ficus carica)  may be considered anti-melanoma remedy, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Fig latex (Ficus carica L. cultivar Dottato) in combination with UV irradiation decreases the viability of A375 melanoma cells in vitro by Menichini G1, Alfano C, Provenzano E, Marrelli M, Statti GA, Somma F, Menichini F, Conforti F. (PubMed)

Tocopherols, A Promising Phytochemical for the Treatment of Asthma

By Kyle J. Norton

Respiratory Disease is a class of medical conditions that affect the breathing organ and tissues including inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc.

The lungs formed part of the respiratory system are a vital organ of the human being, located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream to nourish the body cells need and exhaling carbon dioxide from the bloodstream.

Additionally, the lung is also the first-line defense against inhaled particles and prevent the circulation of emboli such as blood clot (thrombus), a fat globule (fat embolism), a bubble of air or other gas (gas embolism), or foreign material.

Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing.

The disease affects people of all ages, and mostly starts during childhood.

During the asthma attacks, patients may experience symptoms of difficult breathing, and severe wheezing in the breath and coughs that won't stop.

According to the statistic provided by the Centers for Disease Control and Prevention (CDC), 1 in 13 people in the US has asthma.

In other words, more than 26 million Americans have asthma, with half of the patients are children.

If you experience symptoms of a cough which often worse at night or early in the morning, wheezing in your breath, accompanied by chest tightness and shortness of breath, you may be at the early stage of asthma. Please check with your doctor to rule out the possibility.

Genetic and environmental factors are the most common risk factors associated with the onset of asthma. Some researchers suggested that the widespread obesity over the past few decades may also have a strong implication on the onset of the disease.

Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic lung diseases, researchers examined the effects of γ-tocopherols, a specific form of vitamin E, on asthma remission.

According to the analysis,
* γ-tocopherols possesses the capability to reduce the number of eosinophils associated with the immune response against allergy.

* γ-tocopherols inhibited the production of pro-inflammatory cytokines induced by the immune response by exudation of inflammatory cells together with the hyperplasia of goblet cells.

* γ-tocopherols also reduced the high levels of eotaxin, eosinophil chemotactic protein, and IL-4, proinflammatory cytokine in the asthma group comparable with hexadecadrol.

After talking about other factors into account, researchers said, "γ-tocopherols can remit asthma by regulating the level of eotaxin and IL-4. Moreover, γ-tocopherols may be regarded as a potential candidate for asthma treatment after much deeper explorations".

Taken altogether, tocopherols may be considered adjunct therapies in the treatment of asthma, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Comparable Function of γ-Tocopherols in Asthma Remission by Affecting Eotaxin and IL-4 by Wu YM1, Xue ZW1, Zhang LL1, Gao NM1, Du XM1, Zhang XY1, Zhang ZH1, Zhang ZG. (PubMed)
(2) Serum carotenoid and tocopherol concentrations and risk of asthma in childhood: a nested case-control study by Hämäläinen N1, Nwaru BI1,2, Erlund I3, Takkinen HM1,4, Ahonen S1,5,6, Toppari J7,8, Ilonen J9,10, Veijola R11, Knip M12,13,14, Kaila M15,16, Virtanen SM. (PubMed)

Cruciferous vegetables, The Potential Neuro-Protective Healthy Foods

By Kyle J. Norton

Neuroprotection is a process to preserve the neuronal structure and/or function against the death or gradual death of neurons, including the use of medicines and herbs.

In other words, neuroprotection protects the neuronal integrity against the reduction in the rate of neuronal loss over time inducing neurological disease, including neurodegenerative disease.

Neurological diseases are the medical conditions of brain disorder. Anything that involves the structural, biochemical or electrical abnormalities in the brain, spinal cord or other nerves, including brain damage are considered neuro diseases.

Neurodegenerative disease is the class of condition associated with the progressive loss of neuron occurred mostly in older adults, including dementia. The most common dementia in the US is Alzheimer`s disease (AD).

Alzheimer's disease is an irreversible, progressive brain disorder caused by the slowly lost of neuron in the brain that affects the memory and thinking skills and, eventually, the ability to carry out the simplest tasks as the disease progress into advanced stage.

According to the statistic, dementia affects over 47.5 million people worldwide, approximately 58 percent are living within low and middle-income countries.

Believe it or not, 5.8 million Americans of all ages are living with Alzheimer's dementia in 2019 and two-thirds of people with Alzheimer's disease are women.

Conventionally, as of today, there is no cure for dementia. Treatment of dementia is focusing to improve dementia symptoms and slow down the progression of the disease.

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

On finding a potential compound for the treatment of neurological diseases, researchers examined cruciferous vegetable neuroprotective activity.

According to the dietary information,
* SFN, a potent bioactive compound found in the veggies upregulated the nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant response element (ARE) genetic pathway by increasing the antioxidant enzymes produced by the host.

* SFN was found to protect the nervous system from many diseases against and toxins in few small human trials.

* Furthermore, according to the preclinical data, SFN protected the nervous system through multiple mechanisms, reduced the risk of many diseases and the burden of symptoms in existing conditions.

In other words, SFN processed protective effects in a multitude of neurological diseases and toxin exposures.

Based on the evidence, researchers said, "SFN is a promising neuroprotective phytochemical which needs further human trials to evaluate its efficacy in preventing and decreasing the burden of many neurological diseases".

Taken altogether, cruciferous vegetables may be considered neuroprotective functional foods, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The neuroprotective mechanisms and effects of sulforaphane by Klomparens EA1, Ding Y. (PubMed)

Herbal Dandelion(Taraxacum officinale) Inhibits the Parameters Involved in Hepatitis B Infection

By Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.

The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes and produces vitamin D and steroid hormones.

Liver disease is a class of medical conditions characterized by the reducing partly or completely the function of the liver, including liver failure.

Hepatitis B is a liver disease caused by liver inflammation of viral Hepatitis C, leading to irreversible liver scars. Over time, the condition can also induce liver cancer.

The most common symptoms of liver disease are jaundice, abdominal pain and swelling, swelling in the legs and ankles, itchy skin, dark urine color, pale stool color, or bloody or tar-colored stool, chronic fatigue and nausea or vomiting.

According to the statistics from the WHO, in 2015, 257 million people were living with chronic hepatitis B infection (defined as hepatitis B surface antigen-positive). 

In 2015, hepatitis B resulted in an estimated 887 000 deaths, mostly from cirrhosis and hepatocellular carcinoma (i.e. primary liver cancer).

The most common risk factors associated with hepatitis B infection are unprotected sexual contact, sharing needles with someone infected by the virus.

sadly, a mother with hepatitis B infection also can transmit the disease to her child.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of liver diseases, scientists examined the T. mongolicum extract (TME) antiviral effect against the hepatitis B virus (HBV).

According to the tested differentiation, in chemically-injured neonatal rat hepatocytes, DHBV-infected duck fetal hepatocytes and HBV-transfected HepG2.2.15 cells, TME at 50-100 µg/ml
* Inhibited the levels of  D-galactosamine (D-GalN), thioacetamide (TAA) and tert-butyl hydroperoxide (t-BHP)- associated with the injured hepatocytes in rat liver, induced the protection rates of 42.2, 34.6 and 43.8% at 100 µg/ml, respectively.

* TME at 1-100 µg/ml markedly inhibited DHBV DNA replication.

* TME at 25-100 µg/ml reduced HBsAg and HBeAg levels and produced inhibition rates of 91.39 and 91.72% at 100 µg/ml, respectively.

* TME markedly inhibited HBV DNA replication at 25-100 µg/ml.

Collectively, TME inhibited the parameters associated with the initiation of hepatitis B infection involved in the amelioration of oxidative stress.

Based on the findings, researchers said, "The antiviral properties of TME may contribute to blocking protein synthesis steps and DNA replication".

Taken altogether, Dandelion may be considered a remedy for the treatment of hepatitis B infection, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Taraxacum mongolicum extract exhibits a protective effect on hepatocytes and an antiviral effect against hepatitis B virus in animal and human cells by Jia YY1, Guan RF1, Wu YH1, Yu XP1, Lin WY2, Zhang YY1, Liu T3, Zhao J3, Shi SY2, Zhao Y. (PubMed)

Ursolic Acid, A Potential Adjunct Therapy for the Treatment of Lung Cancer

By Kyle J. Norton

The lung is a vital organ of the human being, located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream to nourish the body cells' need and exhaling carbon dioxide from the bloodstream.

Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue.

A most common form of primary lung cancer is derived from epithelial cells. In the Us, Lung cancer causes the death of  158,683 people, including 88,329 men and 70,354 women, according to the 2007 statistic.

Believe it or not, each year, more people die of lung cancer than of colon, breast, and prostate cancers combined.

Most people diagnosed with lung cancer are 65 or older, compared to a very small number of those younger than 45.

Non-small cell lung cancer is the most common type of lung cancer. It usually grows and spreads methodically and predictably. 

Most common types of lung cancers include

* Squamous-cell carcinoma is a type of NSCLC often found in an outer area of the lung.

* Large-cell carcinoma is a type of NSCLC found in the center of the lung by an air tube.

* Adenocarcinoma is a type of NSCLC found in any part of the lung.

The 5 years of the survival rate of never and ever smokers in patients with stage I is 92%, compared to 76%, in smokers.

The 5-year recurrence-free proportions (RFPs) for never and ever smokers were 89% compared to 80%, in smokers.

Ursolic acid is a phytochemical in the subclass of Triterpenoid, belongings to the group of Terpenes found abundantly in apples, basil, bilberries, cranberries, peppermint, lavender, oregano, hawthorn, prunes., etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the effect of ursolic acid (UA) on the stemness of non-small cell lung cancer (NSCLC) cells.

According to the analysis of the NSCLC cells with paclitaxel resistance (A549-PR) which exhibited a remarkably stronger stemness than the parental A549 cells,

* UA administration significantly reduced the stemness and paclitaxel resistance of A549-PR cells.

* UA inhibited the miR-149-5p/MyD88 signaling in the promotion of cancer cell resistance and responsible for UA-mediated effects on the stemness of A549-PR cells.

After talking about other factors into account, researchers said, "UA could attenuate the stemness and chemoresistance of NSCLC cells through targeting miR-149-5p/MyD88 axis".

Taken altogether, Ursolic acid may be considered adjunct therapies in the treatment of non-small cell lung cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The miRNA-149-5p/MyD88 axis is responsible for ursolic acid-mediated attenuation of the stemness and chemoresistance of non-small cell lung cancer cells by Chen Q1, Luo J1, Wu C1, Lu H1, Cai S1, Bao C1, Liu D1, Kong J. (PubMed)