Herbal Angelica in the Promotion of Strong Bones

By Kyle J. Norton

Bone is a hard whitish tissue making up the skeleton in humans which provides a framework for the attachment of muscles and other tissues.

Bone density is the amount of bone mineral in bone tissue. Loss of bone density is found to induce osteoporosis.

Bone density is measured by the young adult bone density mean within 1 standard deviation (+1 or −1). The negative T-score is an indication of loss or lower bone density and the T-score of −2.5 or lower is an indication of osteoporosis.

Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.

The condition is a widespread degenerative disease of skeletal joints and often associated with senescence invertebrates due to excessive or abnormal mechanical loading of weight-bearing joints, arising from heavy long-term use or specific injuries.

The exact causes of osteoporosis are unknown. Neither researchers understood that people with the same health conditions are affected by the imbalance between new bone formation and bone resorption while others do not.

However, researchers do know that certain risk factors such as a lid to increase lifelong calcium-deficient diet, age, female, family history,.... bone structure and overweight are associated with the early onset of osteoporosis.

Furthermore, long-term intake of certain medications such as prednisone and a medical condition such as rheumatoid arthritis are also the osteoporosis prevalent risk factors

According to the statistic, 1 in 3 women and 1 in 5 men older than 50 will suffer from an osteoporosis fracture, worldwide.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential herbal medicine for the prevention and treatment of osteoporosis, researchers examined the Angelicapolysaccharide (AP), the main component of angelica on mesenchymal stem cell (MSC) proliferation and osteoblast differentiation.

According to the results of MSCs treated with different concentrations of AP, AP significantly promoted cell viability, upregulated cyclin D1 associated with progression through the G1 phase of the cell cycle. and increased RUNX2, OCN, ALP, and BMP-2 protein levels involved in osteoblast differentiation in MSCs.

Additionally, AP notably activated PI3K/AKT and Wnt/β-catenin signaling pathways that maintain the integrity of bone mass maintenance by regulating the activity of the bone-forming osteoblasts in MSCs.

Moreover, the administration of AP also upregulated the relative expression level of H19 which has been found to induce osteogenesis and promote trabecular bone growth in a dose-dependent manner.

In other words, the mesenchymal stem cell (MSC) analysis suggested that AP protects bone density by increasing the bone cell formation.

More importantly, in vivo experimentation, the results also indicated a further confirmation of the promoting effect of AP on bone formation.

Taken altogether, Herbal Angelica may be considered a remedy for the protection of bone density, pending to larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Angelica polysaccharide promotes proliferation and osteoblast differentiation of mesenchymal stem cells by regulation of long non-coding RNA H19: An animal study by Xie X1, Liu M2, Meng Q. (PubMed)

Omega 3 Fatty Acid Protects the Liver Against the Onset of Cirrhosis in Vivo

By Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.

The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes and produces vitamin D and steroid hormones.

Liver disease is a class of medical conditions characterized by the reduction partly or completely the function of the liver, including liver failure.

More precisely, the liver disease causes a reduced function in toxin elimination of liver as a result of damage or injury, caused by medication, viral infection...
Liver cirrhosis is a condition of abnormal function of the liver due to damage liver tissue replaced by scar tissue.

In other words, cirrhosis is an irreversible scarring liver as a result of liver tissue by fibrosis due to the final phase of chronic liver diseases that can lead to poor function of the liver and liver failure. 

According to the statistics, the number of discharges with chronic liver disease or cirrhosis as the first-listed diagnosis: 101,000 in 2009 and deaths per 100,000 population: 10.3 in 2010(a). Hepatitis B infection cause of the disease is very prevalent in South-East Asia.

According to statistics, the risk of liver cirrhosis is 1.6% in the adult population.

Most common risk factors associated with the onset of cirrhosis are

Risk factors
* Gender
Females who are chronic alcohol drinkers are at an increase to develop Cirrhosis.

* Diabetes mellitus (DM)
If you are diabetic, you are associated with an increased risk of cirrhosis. According to the study by the University Hospital, Monterrey, about 30% of patients with cirrhosis have diabetes mellitus (DM).

* Excessive alcohol drinking
People who drink abusively, in the most case died as a result of the progression of liver diseases.

* Medication-induced cirrhosis
Certain medications may cause an increased risk of cirrhosis to the takers, such as anti-tuberculosis

* Age
The risk of cirrhosis is increased with the progression of age.

* Obesity
The risk of cirrhosis is increased for obese people. In the study to evaluate the role of obesity.

* Heredity
Alpha-1-anti-trypsin deficiency is the most common genetic cause of liver disease in children.

* Toxins
Toxins can damage the liver.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of liver diseases, researchers examined the effect of omega-3 polyunsaturated fatty acids (n-3 PUFA) on liver regeneration of rats with liver cirrhosis after hepatectomy.

According to the results of Omega-3 polyunsaturated fatty acids intravenously injected in n-3 PUFA group 3 days before the operation to 1 day after partial hepatectomy,

* Liver regeneration was significantly delayed compared with PH group 7 days after hepatectomy (PH) in LC+PH group.

* Liver regeneration of LC+n-3 PUFA*+PH group increased significantly compared with LC+PH group 7 days after PH.

* In LC+PH group, liver cirrhotic was significantly higher compared with LC+n-3 PUFA+PH group 7 days after PH.

* Furthermore, liver cirrhosis of LC+n-3 PUFA*+PH group was significantly reduced compared with LC+n-3 PUFA+PH group 7 days after PH.

* More importantly, anti-inflammatory cytokine IL-10 was increased and pro-inflammatory cytokine IL-6 was decreased in LC+n-3 PUFA*+PH group compared with LC+PH group.

Based on the findings, researchers said, " N-3 PUFA also suppressed increments in mRNA expression for transforming growth factor-β and up-regulated the expression of matrix metalloproteinase-9 and matrix metalloproteinase-1 in the liver".

Taken altogether, Omega-3 fatty acids may be considered a remedy for the prevention and treatment of liver cirrhosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Omega-3 polyunsaturated fatty acids prevent progression of liver fibrosis and promote liver regeneration after partial hepatectomy in cirrhotic rats by Yang Y1, Shao C, Zhang W, Wang G, Lu DC, Han W, Wu ZS, Chen CB. (PubMed)

Field Mustard Modulates the Apoptotic and Inflammatory Responses

By Kyle J. Norton

The inflammatory response (inflammation) is the reaction of the immune system to target the tissues injured by trauma, toxins, heat, and pathogens.

Inflammation is a natural immune response that protects our body against the invasion of stimuli and foreign pathogens.

During the acute phase of infection, the immune first line of defense activates the protein associated with the production of blood palettes to cover the wound and inflammatory cytokines to the site of injury with an aim to prevent and kill off microorganisms.

However, overproduction of inflammatory cytokines not only can induce fever, swelling, and pain to the affected area but also damage to the nearby cells and tissue, leading to the formation of scars.

Chronic inflammatory diseases are the class of conditions involved in low-grade inflammation to the affect tissue or organ. Some researchers suggested that the immune system has evolved over thousands of years to kill off the foreign invasive pathogens within a period of time, normally between 3 to 8 weeks. If the immune fails to do so, it will adapt to the new change, leading to chronic inflammation.

There are several factors that cause the onset of the conditions. Some scientists indicated untreated acute inflammation, such as an infection or injury and an autoimmune disorder involved immune system mistakenly attacking healthy tissue are the most causes of chronic inflammatory diseases.

People with a strong immune system, during the acute phase of infection, the levels of pro-inflammatory cytokines are balanced by the expression of anti-inflammatory cytokines without affecting the immune activity.

However, in children, the elderly and people with the weakened immune system, overexpression of proinflammatory cytokines can damage the nearby cells and tissue, leading to the formation of scars.

On finding a potential plant that improves the apoptotic and inflammatory responses, researchers compared the effects of field mustard polysaccharides (BRPs) on acute liver injury induced by carbon tetrachloride (CCl4).

According to the results of mice that were treated with CCl4 after the oral administration of BRPs (55, 110 and 220 mg/kg) or bifendate (100 mg/kg) for 7 days, BRP pre-treatment significantly decreased the liver toxic markers MDA, ALT, ALP, and AST in the serum, by increasing the levels of SOD and GSH-Px in the liver.

BRPs pretreatment was found to alleviate the hepatocyte injury by inhibiting the expression of proinflammatory proteins and pathways, such as TNF-α, IL-1β, and IL-6, and the CCl4 -induced hepatic tissue apoptosis caspase-3.

Based on the findings, researchers said, "This study demonstrated that BRPs exert hepatoprotective effect against the CCl4 -induced liver injury via modulating the apoptotic and inflammatory responses and downregulating the JAK2/STAT3 signaling pathway".

Taken altogether, field mustard may be considered a functional food to enhance the apoptotic and inflammatory responses, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Brassica rapa polysaccharides ameliorate CCl4-induced acute liver injury in mice through inhibiting inflammatory apoptotic response and oxidative stress by Qiuyue L1, Yang H2, Wang W3, Li N2, Zou X2, Li Y3, Zhang Y4, Kuang T5, Gang F. (PubMed)

Cranberry Speeds Up Wound Healing

By Kyle J. Norton

Wound healing is the natural process of repair of skin damage and injury.

The process of skin healing in humans is gone through several stages. First, the immune system after sensing the skin wound activates the immune first-line defense stimulating the constriction of the blood vessel to reduce blood flow, activate platelets, and many different clotting factors to cover the wound area.

Then, the white blood cells also up-regulate the proteins associated with the production of proinflammatory cytokines to the site of infection to kill off all the invasive organisms.

In most cases, due to the overproduction of proinflammatory cytokines, patients may experience symptoms of fever, and localized pain, redness, and swelling.

The process of wound healing involves 4 phases
* The first phase of wound healing is cover up the wound. In this phase, the immune first line of defense white blood cells stimulates the emergency repair system in the production of blood clotting to block the drainage.

* In phase 2, the white blood cells activates the proteins associated with the inflammatory cytokines to destroy the pathogens before they can enter the body through the wound.

* In phase 3, new blood vessels and tissues are formed in the damage and injury area.

* The recovery phase.

However, the healing process is easier said than done, the complex process in many cases can be interrupted by local and systemic factors, including moisture, infection, age, and nutritional status, leading to the formation of scar

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the promotion of skin healing, researchers compared the pharmacological properties of the phytochemical constituents present in oils of cranberry on wound healing.

Selected animals in the study were divided into four groups of six each (n = 6) as follow,
* The experimental group 1 and 2 animals were treated topically with the grape and cranberry oil (100 mg/kg body weight), respectively.

* The controls were treated with petroleum jelly.

* The standard group of animals was treated with mupirocin ointment (100 mg/kg body weight).

According to the healing process assays,
* On day 13, animals treated with cranberry oil showed a better reduction in the wound area of 88.1%  compared with grape-oil treated of 84.6%, 74.1% in control and 78.4% in standard group animals.

* Furthermore, the hydroxyproline content of the granulation tissue was significantly higher in the animals treated with cranberry and the grape-oil compared to control and standard groups.

In other words, cranberry oil exerted the strongest effects in the promotion of wound healing compared to other experimental groups.

Collectively, researchers wrote, "Comparative investigation of the curative properties of the oils of V. vinifera and V. macrocarpon revealed a significant result which suggests their wound-healing potential".

Taken altogether, cranberry oil may be considered a topical remedy for speeding up wound healing, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Wound-healing properties of the oils of Vitis vinifera and Vaccinium macrocarpon by Shivananda Nayak B1, Dan Ramdath D, Marshall JR, Isitor G, Xue S, Shi J. (PubMed)

Beta-Sitosterol Shows a Protective Effect on Alzheimer's

By Kyle J. Norton

Neurological diseases are the medical conditions of brain disorder. Anything that involves the structural, biochemical or electrical abnormalities in the brain, spinal cord or other nerves, including brain damage are considered neuro diseases.

The most common neurodegenerative diseases in the elderly are dementia. Depending on the brain regions that are damaged or dysfunction, dementia can be Parkinson's, Alzheimer's,...and Huntington's disease.

Genetic mutation inherited from parents such as the NOTCH3 gene is the most common autosomal dominant that cause of stroke and vascular dementia.

Neurodegenerative diseases are a class of conditions associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.

Dementia is a cluster of conditions included Parkinson’s, Alzheimer’s, and Huntington’s disease, leading to a negative influence on the body's functioning, including balance, movement, talking, breathing, and heart function.

There is no single cause of the progressive death of brain neurons. Epidemiologically, genetic preposition, medical conditions, such as alcoholism, brain cancer or a stroke in the brain are some of the most common prevalent factors found in patients with neurological diseases.

A most common form of neurodegenerative diseases in North America is Alzheimer's disease (AD).

Alzheimer's disease is a brain disorder correlated with major reductions of neurons to the respective target areas through destruction of brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal.

According to statistics, over 25 million people in the world today are affected by dementia and most are suffering from Alzheimer's disease.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of neurodegenerative diseases, researchers elucidated the effects of sterol β-Sitosterol on the production of platelet Aβ in Alzheimer's disease (AD).

According to the results in learning and memory in amyloid protein precursor/presenilin 1 (APP/PS1) double transgenic mice which were treated with β-Sitosterol for four weeks, 

* β-Sitosterol treatment improved spatial learning and recognition memory ability, and reduced plaque load in APP/PS1 mice.

* β-Sitosterol treatment reversed dendritic spine loss in APP/PS1 mice and reversed the decreased hippocampal neuron miniature excitatory postsynaptic current frequency.

In other words, β-Sitosterol demonstrated a neuroprotective effect which may offer a novel pharmaceutical agent for the treatment of AD.

Based on the findings, researchers said, " these findings suggest that β-Sitosterol ameliorates memory and learning impairment in APP/PS1 mice and possibly decreases Aβ deposition".

Beta-Sitosterol may be considered a remedy for the prevention and treatment of AD, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) β-Sitosterol treatment attenuates cognitive deficits and prevents amyloid plaque deposition in amyloid protein precursor/presenilin 1 mice by Ye JY1, Li L1, Hao QM1, Qin Y1, Ma CS. (PubMed)

Broccoli Kills Non‑Small Cell Lung Cancer Cells in Vitro

By Kyle J. Norton

Cancer is a class of disease characterized by cell growth disorderly and uncontrollably in the tissues and organs.

The lung is a vital organ in humans, located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream to nourish the body cells' need and exhaling carbon dioxide from the bloodstream.


Lung cancer is a medical condition characterized by abnormal growth of the cells in the lung's tissue.

The most common form of primary lung cancers is derived from epithelial cells.

According to the statistics provided by the American Cancer Society, in the US, lung cancer is the leading cause of cancer deaths.

In 2007, lung cancer causes the death of 158,683 people, including 88,329 men and 70,354 women.

Non-small cell lung cancer, the most common type of lung cancer grown and spread methodically and predictably, includes
* Squamous-cell carcinoma often found in an outer area of the lung.

*Large-cell carcinoma found in the center of the lung by an air tube.

* Adenocarcinoma found in any part of the lung.

Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding a potential plant that processes anticarcinogenic activity, researchers examined the chemotherapeutic and anti‑cancerogenic capacities of SFN in non‑small cell lung cancer cell lines.

In vitro, according to the results of the non‑small cell lung cancer cell line H1299 was treated with increasing concentrations of SFN (5, 10 and 15 µM) for two days,

* SFN‑induced cell cycle arrest was associated with a decrease in cyclin B1 expression in cell cycle regulation.

* Non-small lung cancer cells treated with SFN also induced the higher levels of cyclin D1 and cyclin K in the induction of cell cycle arrest or apoptosis.

In other words, SFN induced cancer cell apoptosis, cell cycle and expression of selected cell cycle‑associated proteins Cyclin B1, cyclin D1 and cyclin K.

Taken altogether,  broccoli processed a high amount of SFN may be considered a functional food for the prevention and treatment of non‑small cell lung cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Expression of cyclin B1, D1 and K in non‑small cell lung cancer H1299 cellsfollowing treatment with sulforaphane by Żuryń A1, Krajewski A1, Klimaszewska-Wiśniewska A2, Grzanka A1, Grzanka D. (PubMed)

Serum of Tocopherols Is Associated with Reduced Risk of Oral Cancer

By Kyle J. Norton

Cancer is a class of diseases in which a group of cells growing and multiplying disorderly and uncontrollably in our body.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Mouth/oral cancer is a medical condition associated with the irregular cell growth on the tissue of the mouth caused by genetic alteration of the cell DNA.

Most cases of mouth cancer start in the flat, thin cells (squamous cells) of the inner lining tissue that line the lips and the inside of the mouth.

According to the statistics provided by the American cancer society, in 2018, approximately, over 50,000 people will get oral cavity or oropharyngeal cancer. An estimated over 10,000 people will die of these cancers.in the United States.

The exact causes of mouth cancer are unknown. However, the increase in age, gender, exposure to radioactive, long-term use of tobacco use and excessive alcohol drinking, viral infection and genetic mutation are the most common prevalent risk factors found in people with mouth cancer.

Risk factors associated with the onset of mouth cancer are
* Smoking
In the studies of studies, Cancer Prevention Study (CPS) I and II, sponsored by the American Cancer Society (ACS), researchers found that the mortality risk for oral cancer in cigarette smokers is substantially greater than that observed among life long never smokers.

* Alcohol drinking
Alcohol drinking is known to promote oral cancer. Oral cancer risk increases if a person is both a heavy smoker and drinker.

*  Chewing tobacco
Maybe as a result of irritation of the mucous membranes of the mouth from chemicals in the tobacco.

* Chewing betel nut

May be caused by a chemical compound which irritates the mucous membranes of the mouth

* Age
Most cases of oral cancer are diagnosed at ages of over the fifties.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers investigated associations between retinol, α-tocopherol, and β-carotene with the risk of oral cancer.

The comparative cross-sectional study included a total of 240 involving oral cancer patients and healthy individuals matched cases and controls where subjects were selected from the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS).

According to the analysis,
* Serum levels of retinol and α-tocopherol among cases (0.177±0.081, 1.649±1.670μg/ml) were significantly lower than in controls (0.264±0.137, 3.225±2.054μg/ml) (p<0.005) compared to treatment group.

* Serum level of β-carotene among cases (0.106±0.159 μg/ml) were lower compared to controls (0.134±0.131μg/ml)

These results suggested that high serum levels of retinol (OR=0.501, 95% CI=0.254-0.992, p<0.05) and α-tocopherol (OR=0.184, 95% CI=0.091-0.370, p<0.05) was significantly related to lower risk of oral cancer.

After talking about other factors into account, researchers said, "High serum levels of retinol and α-tocopherol confer protection against oral cancer risk".

Taken altogether, tocopherols may be considered an adjunct therapy in the treatment of oral cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) High serum level of retinol and α-tocopherol affords protection against oral cancer in a multiethnic population by Athirajan V1, Razak IA, Thurairajah N, Ghani WM, Ching HN, Yang YH, Peng KN, Abdul Rahman ZA, Mustafa WM, Abraham MT, Kiong TK, Mun YK, Jalil N, Zain RB. (PubMed)