Omega-3 Fatty Acids, the Healthy Fat for the Treatment of Myocardial Infarction

By Kyle J. Norton


Stroke is the third leading cause of death. Approximately 1/4 of all stroke victims die as a direct result of the stroke or its complications.

Stroke is caused by the accumulation of cholesterol and other substances that build up the arterial walls.

 In other words, if cholesterol building up in the arteries is blocking the circulation of blood in any part of the body causing oxygen not to be delivered to the brain, leading to the death of some cells in the brain.

According to the statistics, every year, more than 790,000 people suffer a stroke, including 600,000 of these are first attacks, and 185,000 are recurrent attacks. Most cases of stroke occur in people over the age of 65.

Myocardial infarction (MI) is a medical condition known as heart attacks caused by the blood flow decreases or stops to a part of the heart, leading to the damage to the heart muscle.

In other words, myocardial infarction (MI) occurs due to the imbalance in oxygen supply and demand caused by plaque rupture with thrombus formation in an artery, leading to the reduced blood flow to the heart.

Prompt treatment can minimize brain damage and potential post disease complications.

The most common symptoms of MI are pressure, tightness, pain, or a squeezing or aching sensation in your chest, digestive discomforts such as nausea, indigestion, heartburn, abdominal pain, shortness of breath and dizziness.

Conventionally, treatment of myocardial infarction is the focus to reduce the damage of the heart muscle accomplished through medical or mechanical means.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of post-stroke, researchers examined the omega-3 eicosapentaenoic acid (EPA) EPA the infarct-limiting effect on experimental models.

The observational study conducted in 100 patients with a reperfused anterior ST-elevation myocardial infarction (STEMI), at hospital admission who are quantified by gas-chromatography the red blood cell proportions of AA, EPA, and the AA: EPA ratio, a valid surrogate for cardiomyocyte membrane content.

According to the results of the tested analysis,

* AA:EPA ratio directly related to acute infarct size (coefficient [95% CI]: 6.19 [1.68 to 10.69], P = 0.008) and inversely to long-term cardiac function (left ventricular ejection fraction [LVEF]) (coefficient [95% CI]: − 4.02 [− 7.15 to − 0.89], P = 0.012), comapred to uintreated control.

* EPA inversely related to acute infarct size (coefficient [95% CI]: − 6.58; [− 11.46 to − 1.70]; P = 0.009), while a direct association with LVEF at follow-up (coefficient [95% CI]: 3.67 [0.25 to 7.08]; P = 0.036) was observed.

In other words, both application omega 3 fatty acids demonstrated protective activity to preserve the neuron against damage immediately after the incidence of stroke.

Additionally, researchers also found, " A low AA: EPA ratio in red blood cells at the time of STEMI is associated with smaller acute infarct size and preserved long-term ventricular function".

Collectively, they said, "Our results are consistent with prior work in experimental models and add to the notion of omega-3 fatty acids as a healthy fat".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the treatment of myocardial infarction, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Nutritional preconditioning by marine omega-3 fatty acids in patients with ST-segment elevation myocardial infarction: A METOCARD-CNIC trial substudy by Sala-Vila A1, Fernández-Jiménez R2, Pizarro G3, Calvo C1, García-Ruiz JM4, Fernández-Friera L5, Rodriguez MD4, Escalera N4, Palazuelos J6, Macías A4, Pérez-Asenjo B4, Fernández-Ortiz A2, Ros E1, Fuster V7, Ibáñez B. (PubMed)

Tocopherols, an Effective Adjunct Therapy Against Drug-Resistant Cancer Cells

By Kyle J. Norton

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Chemotherapy resistance is the resistance of cancerous) cells to allow them to cancer cells to survive and grow despite anti-cancer therapies.

Multiple drug resistance of cancer cells is a type of cancer cell that resistance to multiple drugs.

An article from Chemocare suggested the possible reasons for chemotherapy resistance:

"* Some of the cells that are not killed by the chemotherapy mutate (change) and become resistant to the drug. Once they multiply, there may be more resistant cells than cells that are sensitive to chemotherapy.

* Gene amplification. A cancer cell may produce hundreds of copies of a particular gene. This gene triggers an overproduction of a protein that renders the anticancer drug ineffective.

* Cancer cells may pump the drug out of the cell as fast as it is going in using a molecule called p-glycoprotein.

* Cancer cells may stop taking in the drugs because the protein that transports the drug across the cell wall stops working.

* The cancer cells may learn how to repair the DNA breaks caused by some anti-cancer drugs.

* Cancer cells may develop a mechanism that inactivates the drug".

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the effect of two novel α-tocopheryl-lipoic acid conjugates (TL1 and TL2) that form stable nanovesicles synthesized for the anticancer drug, doxorubicin (DOX), delivery. Both conjugates were able to form stable nanovesicles.

According to the analysis,
* The encapsulation efficiency similar to those of commonly used anticancer drug, doxorubicin (DOX), in nanovesicles was found to be ∼60% and ∼55% for TL1 and TL2, respectively (TL1-DOX and TL2-DOX).

* The cumulative drug (DOX) release from DOX-encapsulated nanovesicles in response to biological reducing agent glutathione (GSH) was ∼50% and ∼40% for TL1-DOX and TL2-DOX, respectively, over a period of 10 h.

* Furthermore, both TL1-DOX and TL2-DOX delivered the anticancer drug, doxorubicin (DOX), across the DOX-sensitive and DOX-resistant HeLa (HeLa-DOXR) cells in an efficient manner and significantly more efficaciously than the drug alone treatments, especially in HeLa-DOXR cells.

Moreover, the nanovesicle mediated DOX treatment also showed significantly higher cell death when compared to DOX alone treatment in HeLa-DOXR cells.

After talking about other factors into account, researchers said, "we present biocompatible and responsive nanovesicles for efficacious drug delivery to drug-sensitive and drug-resistant cancer cells".

Taken altogether, tocopherols may be considered an adjunct therapy in the treatment of drug-resistant cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Reduction Responsive Nanovesicles Derived from Novel α-Tocopheryl-Lipoic Acid Conjugates for Efficacious Drug Delivery to Sensitive and Drug-Resistant Cancer Cells by Maiti B1,2, Kumar K1,2, Moitra P1,2, Kondaiah P1,2, Bhattacharya S. (PubMed)
(2) Chemotherapy Resistance by Chemocare

Cranberry Improves the Lipid Profiles in Patients with Diabetes and Metabolic Syndrome

By Kyle J. Norton

Fat including cholesterol and triglycerides consists of hydrocarbon molecules.

Cholesterol is the type of fat produced by the liver or from fat intake that plays a critical role in the building of strong cell walls, production of vitamin D and steroid hormones and bile acid to aid digestion in the small intestine.

Accessed cholesterol produced by the liver in a healthy individual is returned to the liver by high-density lipoprotein (HDL).

Overexpression of cholesterol levels in the bloodstream has been linked to plaques accumulation on the arterial walls, a major cause of some forms of heart disease and stroke.

The healthy ratio of HDL/LDL cholesterol is any numbers that are less than 1/4.

Triglyceride is fat in the blood that comes from the outside source used by the body to convert to energy.

Triglyceride is stored in the fat cells used to produced energy between meals and in the case when food is scarce.

Compared to cholesterol, triglycerides in high levels also associated with the risk of heart disease, particularly in people with high levels of LDL and low levels of HDL.

Evolutionally, fat accumulation is considered a defense mechanism in the human body where excess fat is stored when foods are plentiful and release to produce energy when foods are scarce.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of cardiovascular diseases, researchers investigated berries, including cranberry as whole fruits, juices, and purified extracts on lipids and lipoproteins in diabetes and metabolic syndrome.

Berry extracts application showed to improve other lipid profiles, by lowering LDL and increasing HDL cholesterol (C), as well as inhibiting the triglyceride-rich lipoproteins in diabetes and metabolic syndrome in the tested subjects.

Furthermore, in clinical studies, berry extracts lowered the total and LDL-C and increased the HDL-C in participants with elevated blood lipids, type 2 diabetes or metabolic syndrome.

Based on the emerging evidence, researchers said, "colorful berry fruits may thus be included in a healthy diet for the prevention and management of CVD".

Taken altogether, cranberry may be considered a remedy for the normalization of lipid profile, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Role of Berry Bioactive Compounds on Lipids and Lipoproteins in Diabetes and Metabolic Syndrome by Basu A. (PubMed)

Healthy Foods Cruciferous vegetables Inhibit the Onset of Caused by Genotoxicity

By Kyle J. Norton

Genotoxicity is a process of destruction on a cell's genetic material (DNA, RNA), leading to gene mutation.

In other words, genotoxins are mutagens, the substances which have been found to induce cancer. The most common genotoxins are radiation and toxic chemicals.

Believe it or not, besides causing cancer, genotoxins are found to induce various types of genetic diseases, by the damage of the germ cell.

Some researchers suggested that the damage of DNA may be controlled if the genotoxins are identified through the use of anti antimutagens /anti-clastogens that suppress or inhibit the mutagenesis process.

The most common causes of genetic damage or alternation are reactive oxygen species (ROS), the unstable and genotoxic molecules that exist everywhere in the environment and inside the human body.

The antigenotoxic activity is a process to inhibit the property of chemical agents that induce damages to the genetic information, leading to mutation,

Cancer is a class of diseases associated with alternation of cell DNA or genetic change of cell.

Not all Genotoxicity is mutagenicity, but all mutagens are genotoxic.

Dr. Shareen H, the lead scientist in the study of "Chapter 18 - Genotoxicity and Cancer" wrote, "Genetic toxicology is the study of chemical and physical perturbations to DNA following exposure to endogenous or exogenous agents. Hazard assessment of engineered nanomaterials involves establishing the ability of these novel materials to induce DNA damage (genotoxicity) and to subsequently initiate tumor formation (carcinogenesis)".

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

On finding a potential compound for the protection of cell DNA against damage, researchers examined the effects of cruciferous vegetables (CF) in protecting humans against cancer caused by chemically induced tumor formation.

According to the dietary information,

* CF and their constituents showed the effect on enzymes involved in the metabolism of DNA-reactive carcinogens.

* In vitro models, sulforaphane, a bioactive compound found in CF exerted antigenotoxic effects on metabolically competent cell lines.

* Furthermore, Brassica juices induced the production of glutathione-S-transferases (GST) and cytochrome P-450 1A2 in human hepatoma cells (HepG2) against the genotoxic effects of B(a)P and other carcinogens.

* Moreover, brussels sprouts- and garden cress juices attenuated IQ-induced DNA-damage and preneoplastic lesions in the colon and liver of rats.

* Most importantly, CF affects drug metabolism in humans and consumption of red cabbage led to changes in the pattern of meat-derived urinary mutagenicity.

Taken altogether, cruciferous vegetables may be considered functional foods for the protection of the cells against genotoxicity, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of cruciferous vegetables and their constituents on drug-metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens by Steinkellner H1, Rabot S, Freywald C, Nobis E, Scharf G, Chabicovsky M, Knasmüller S, Kassie F. (PubMed)
 b(2) Chapter 18 - Genotoxicity and Cancer by Shareen H.Doak, Ying Liu, and ChunyingChen. (Science Direct)

Omega-3 Fatty Acids Improve Oral Mucositis and Body Weight Loss in Chemoradiotherapy Patients with Head and Neck Cancer

By Kyle J. Norton


Cancer is a class of diseases in which a group of cells growing and multiplying disorderly and uncontrollably in our body.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

Head and neck cancer is a group of cancers found in the mouth, throat, larynx, sinuses, or salivary glands.

Most cases of head and neck cancer, at the early stage, start by the cell growth irregularly and disorderly on the surface of the inner lining in the head and neck.

At the advanced stage, patients may experience symptoms of a lump in the nose, neck or throat, with or without pain, a persistent sore throat that does not heal, trouble swallowing (dysphagia) and frequent and persistent coughing.

At this stage, cancer cells may travel a distance away from the original site to infect other healthy tissue and organs.

Most common head and neck cancer metastases are secondary skin cancer.

The exact causes of head and neck cancer are unknown. Researchers cannot explain why people with similar health conditions and the same risk factors, are susceptible to the onset of the disease, while others do not.

Some researchers suggested that people who perform oral sex before sexual intercourse is at a higher incidence of disease development as human papillomavirus (HPV) can spread during oral sex, increasing the possibility of oral cancer.

 mitted virus.

According to the statistics, head and neck cancer accounts only for about 4% of all cancers in the US. In 2019, an estimated 65,410 people (48,000 men and 17,410 women) were fund to develop head and neck cancer. 

Most people diagnosed with head and neck cancer are older than 50.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of cancer, researchers investigated the effect of a nutritional supplement with a high blend ratio of w-3 fatty acids(Prosure®) on body weight loss, oral mucositis in patients with head and neck cancer.

The study included 17 patients with oropharyngeal and hypopharyngeal cancer who were treated with concomitant cisplatin and 70 Gy of radiotherapy with or without 2 packs of Prosure®per day during chemoradiotherapy.

According to the final results,

* The reduction in body weight was significantly improved compared with that in the historical control group that did not receive Prosure®(7.3% vs 10.3%, p<0.01),

* The rate of Grade 3-4 oral mucositis was significantly reduced for the patient groups that received Prosure®(CTCAE v3.0 GradeB3; 24% vs 58%, p<0.05).

Most importantly, the completion rate of chemoradiotherapy was not significantly different between both groups(77% vs 60%, NS).

Based on the evidence, researchers said, "A nutritional supplement with a high blend ratio of w-3 fatty acids(Prosure®)had effects on oral mucositis and body weight loss in head and neck cancer patients treated with chemoradiotherapy".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention of breast cancer by reducing the breast density, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [A Nutritional Supplement with a High Blend Ratio of ω-3 Fatty Acids(Prosure®) Reduces Severe Oral Mucositis and Body Weight Loss for Head and Neck Cancer Patients Treated with Chemoradiotherapy].[Article in Japanese] by Mizumachi T1, Kano S, Homma A, Akazawa M, Hasegawa C, Shiroishi Y, Okamoto C, Kumagai S, Nishimura M, Takasaki H, Takeda H, Yasuda K, Minatogawa H, Dekura Y, Onimaru R, Shirato H, Fukuda S. (PubMed)
(2) A randomized clinical trial with two doses of a omega 3 fatty acids oral and arginine enhanced formula in clinical and biochemical parameters of head and neck cancer ambulatory patients by de Luis DA1, Izaola O, Cuellar L, Terroba MC, de la Fuente B, Cabezas G. (PubMed)

Tocopherols Inhibits the Onset of Colon Cancer in Vitro

By Kyle J. Norton

The colon also is known as the large bowel or large intestine, formed parts of the digestive system in our body.

The colon consists of four parts: descending colon, ascending colon, transverse colon, and sigmoid colon.

The main functions of the colon are to reabsorb fluids and process waste products from the body and prepare for its elimination.

Colon cancer is a chronic condition caused by cell growth irregularly and disorderly in the colon due to the alternation of DNA.

Most cases of colon cancer start in the cells on the surface of the inner lining of the colon. The stage of colon cancer is depended on how far the alternated cells have spread in the colon.

Patients with the early stage of colon cancer, may not experience any symptoms. But as the tumor spread and expanse, it may suppress the nearby tissue and nerve, causing symptoms of locally severe pain and discomforts.

Although there are many risk factors associated with the early onset of colon cancer, a poor diet high in saturated fat and trans fat, red meat and processed foods have been found to play a major role in the development and recurrence of colon cancer in the Western world.

According to the statistic by the American Cancer Society, in the US, there are
97,220 new cases of colon cancer diagnosed in 2018. The lifetime risk of developing colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

The causes of colon cancer are unknown but certain risk factors, such as genetic preposition and chronic inflammation induced by colonic diseases are associated with the onset of the disease.

According to the statistics provided by the Canadian Cancer Society, In Canada, the 5-year net survival for colorectal cancer is 65%.

In other words, out of 100 people diagnosed with colon cancer, 65% of people will survive for at least 5 years after their diagnosis.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the effect of co-treatment of γ-tocopherol and 5-FU in enhancing the efficacy of chemotherapy against HT-29 colon cancer cells.

According to the analysis,
* The IC50 values for 5-FU and γ-tocopherol were 21.8  ± 2.5 and 14.4 ± 2.6 μM, respectively, and also this combination therapeutic increased the percentage of apoptotic cells from 35% ± 2% to 40% ±  4% (P  <  .05).
* Incubation HT-29 colon cells with combined concentrations of two drugs also caused significant accumulation of cells in the subGsubG1 phase.

After talking about other factors into account, researchers said, "Our results presented the combination therapy with 5-FU and γ-tocopherol as a novel therapeutic approach, which can enhance the efficacy of chemotherapy".

Taken altogether, tocopherols may be considered an adjunct therapy in the treatment of colon cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Adjuvant therapy with γ-tocopherol-induce apoptosis in HT-29 colon cancer via cyclin-dependent cell cycle arrest mechanism by Bazzaz R1, Bijanpour H2, Pirouzpanah SMB2, Yaghmaei P1, Rashtchizadeh N. (PubMed)

Herbal Angelica Processes Anti Liver Cancer Activity in Vivo

By Kyle J. Norton

The liver is the largest internal organ located in the upper right portion of the abdomen, beneath your diaphragm and above your stomach.

The liver not only plays a critical role to filter the blood coming from the intestine before passing them to other parts of the body but also protects our body against toxin by detoxifying chemicals and metabolizes drugs.
The liver organ is one of the organs with a lack of nerve tissues, therefore liver cancer does not induce pain until the later stage.

Cancer is a class of diseases characterized by the irregular cell growth on the body tissue, due to the alternation of cell DNA.

A primary tumor or original tumor is a tumor that is at the original site where it first arose where tumor progression began and proceeded to yield a cancerous mass.

Cancer cells that grow to its tumor size, can invade and kill their neighbor cells by producing abnormal or excessive signaling chemicals (hormones or cytokines) which upset the normal chemical balance of the body and alter the metabolic pathways, leading to disordered and violent cellular behavior.

Liver cancer is a medical condition characterized by cell growth irregularly and uncontrollably in liver tissue.

At the late stage, the cancerous cells may travel a distance away from the original site to infect other healthy tissues.

According to statistics, approximately, 40000 adults in the United States will be diagnosed with primary liver cancer every year.

The disease also causes the annual death of 17,000 men and 8,000 women.

The 5-year survival rate of people who are diagnosed with liver cancer is 18%.

However, the 5 years of early diagnosis survival rate is 31%.

Liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.

Birth defects, alcohol abuse, and chronic liver infection are most causes of liver cancer, diabetes and hemochromatosis also are associated with increased risk of chronic disease.

The most common risk factor of liver cancer is associated with hepatitis viral infection. People with chronic infection with HBV or HCV are found in the high percentage of patients with liver cancer.
The most common symptoms of liver cancer include jaundice, abdominal pain unexplained weight loss, an enlarged liver, fatigue,.... and back pain.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding the natural remedy for the p[revention and treatment of malignant tumor, scientists investigated the effects of Angelica Sinensis polysaccharide (ASP), a plant polysaccharide on liver cancer.

More precisely, Angelica Sinensis polysaccharide (ASP) was modified with a hydrophobic group (deoxycholic acid) to fabricate amphiphilic conjugate (ASP-DOCA) for a better release into the tissues.
According to the results of the DOX loaded nanoparticles (DOX/ASP-DOCA NPs) on hepatoma-targeted delivery of therapeutic drug doxorubicin (DOX), DOX/ASP-DOCA NPs induced a higher anti-proliferation effect than DOX-loaded dextran derivative DOX/DEX-DOCA NPs.

Furthermore, DOX/ASP-DOCA NPs showed higher inhibition on the growth of HepG2 multicellular spheroids (MCs) than DOX/DEX-DOCA NPs.

Moreover, In vivo, ASP-DOCA NPs specifically targeted HepG2 tumors via ASGPR, improved the accumulation of DOX/ASP-DOCA NPs in tumors and generated superior antitumor activity compared with free DOX and DOX/DEX-DOCA NPs.

Collectively, researchers said, " amphiphilic conjugate (ASP-DOCA) NPs possess potential applications in drug delivery systems targeting liver cancer".

Taken altogether, Herbal Angelica processes anti-proliferative activity against cancer, pending to larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Angelica Sinensis polysaccharide nanoparticles as a targeted drug delivery system for enhanced therapy of liver cancer by Zhang Y1, Cui Z1, Mei H2, Xu J2, Zhou T1, Cheng F1, Wang K. (PubMed).