Beta-Sitosterol Demonstrates Anti-Hyperuricemic Effects in Vivo

By Kyle J. Norton

Anti-hyperuricemic activity is the process including the use of anti-Xanthine oxidase inhibitors to reduce the levels of uric acid levels in the body.

Uric acid, the form of ions and salts is a by-product of chemical after the body breaks down purines, the substance is found in many foods, including Asparagus, Bacon, Beef, Bluefish, Bouillon, Calf tongue, Carp, Cauliflower, Chicken, Chicken soup, Codfish, Crab, Duck, Goose, etc.. 

High levels of uric acid in blood serum can be harmful, leading to gout and forming of kidney stones.

Gout mostly affected one joint, is an acute and recurrent condition of arthritis as a result of uric acid building up in the blood, inducing joint inflammation.

According to a cross-sectional survey of a total of 6584 adults (3394 women, 3190 men) conducted by Second Military Medical University, on the prevalence of musculoskeletal symptoms, rheumatoid arthritis (RA), ankylosing spondylitis (AS), and gout showed that symptoms occurred more frequently in the following sites:
* Knee 7.0%
* Lower back 5.6%(95% CI 5.0-6.2%),
* Shoulder 4.7%
* Neck 2.4%
Women complained of rheumatic symptoms more frequently than men. In fact, symptoms are quite noticeable, you may feel well when you go to bed but wake up during the night with intense pain in one or few joints and some times with fever. The symptoms may go away in a few days but can return from time to time. Chronic gout can cause lumps below the skin around joints.

Kidney stones are composed of mineral salts formed in the kidneys. Men account for 80% of those with kidney stones and are at risk of the formings between 30 and 40 years of age. About 75% of kidney stones are calcium stones.

Uric acid stones occur in 10% of all kidney stones and are the second-most-common cause of urinary stones after calcium oxalate and calcium phosphate calculi(

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of diseases associated with uric acid, researchers elucidated the L. trichocarpha ethanolic extract (LTE), ethyl acetate fraction from ethanolic extract (LTA) and isolated compounds urate-lowering activity and liver xanthine oxidase (XOD) inhibition on oxonate-induced hyperuricemic mice.

According to the tested differentiation,

* Crude ethanolic extract and its ethyl acetate fraction showed significant urate-lowering effects.

* LTE also significantly inhibited liver xanthine oxidase (XOD) activity in vivo at the dose of 250mg/kg.

* Luteolin, apigenin, lupeol, lychnopholide, and eremantholide C isolated compounds showed anti-hyperuricemic activities among tested compounds.

* Furthermore, LTE, LTA, lupeol, β-sitosterol, lychnopholide, eremantholide, luteolin, and apigenin were also found to inhibit monosodium urate crystals-induced paw edema in mice.

Based on the findings, researchers said, "Ethanolic extract of Lychnophora trichocarpha and some of its bioactive compounds may be promising agents for the treatment of gouty arthritis since they possess both anti-hyperuricemic and anti-inflammatory properties".

Taken altogether, beta-Sitosterol found abundantly in Ethanolic extract of Lychnophora trichocarpha may be considered a supplement for the prevention and treatment of hyperuricemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents by de Souza MR1, de Paula CA, Pereira de Resende ML, Grabe-Guimarães A, de Souza Filho JD, Saúde-Guimarães DA. (PubMed)

Tocopherols inhibits the Onset of Esophageal Cancer in Vivo

By Kyle J. Norton

The esophagus or gullet, an organ in vertebrates, is the tube that leads foods from the pharynx to the stomach.

Esophageal cancer is not very uncommon, caused by malignant of the esophagus due to abnormal cell growth as a result of the DNA alternation of the cells that line the upper part of the esophagus or glandular cells that are present at the lower part of the esophagus that connected with the stomach.

Esophageal cancer tends to spread if it left untreated and starts from the lining of the esophagus, then later penetrates the wall of the esophagus and spread to the lymph node around the bottom of the esophagus, stomach and the chest, then to the distant parts of the body.

Most common types of esophageal cancer

* Squamous cancer
In the upper part of the esophagus caused by the squamous cell of which has become malignant caused by mutation of DNA in cells replication of division uncontrollably.

* Adenocarcinomas
In the lower part of the esophagus caused by the glandular cells of which have become malignant caused by mutation of DNA in cells replication of division uncontrollably.

According to the statistics provided by the American Cancer Society, in 2019, approximately 17,650 new esophageal cancer cases will be diagnosed, including 13,750 in men and 3,900 in women.

Also, in 2019, esophageal cancer will also cause the death of 16,080 Americans, including 13,020 in men and 3,060 in women.

The 5-year survival rate of people diagnosed in the local stage of esophageal cancer is 45%, much less than other cancer, including 100% of breast cancer.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the effect of dietary tocopherols on esophageal carcinogenesis.

According to the analysis,
* In murine models, dietary tocopherols significantly prevent esophageal cancer by inhibiting the activation of NF-κB, associated with blocking the cancer cell apoptosis and the subsequent interaction of chemokine CXCL9/10/11 with their receptor CXCR3 to prevent ESCC proliferation, angiogenesis, and metastasis.

* Furthermore, dietary supplementation with 0.15% α-tocopherol (α-T), δ-tocopherol (δ-T), or γ-tocopherol rich mixture (γ-TmT) markedly suppressed the production of pro-inflammatory cytokines, as well as the induction of CXCR3+ effector T cells (CD4+ Th1 and CD8+ CTLs) infiltration, at the early stage of carcinogenesis.

In other words, dietary tocopherols significantly that prevent the onset of esophageal cancer In experiments in vivo and in vitro, were tightly correlated with the blockade of NF-κB activation

After talking about other factors into account, researchers said, "tocopherols decrease carcinogenesis through inhibiting NF-κB and CXCR3 signaling, as well as related inflammation in early premalignant lesions. This pathway may offer a novel target for chemoprevention of esophageal cancer".

Taken altogether, tocopherols may be considered a remedy for the prevention of the onset of esophageal cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tocopherols inhibit esophageal carcinogenesis through attenuating NF-κB activation and CXCR3-mediated inflammation by Yang H1, Xu M2, Lu F3, Zhang Q4, Feng Y4, Yang CS5, Li N4, Jia X. (PubMed)

Herbal Angelica Prevents Oxidative Injury in Vivo

By Kyle J. Norton

Oxidative stress is a medical condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissue.

In some cases, this reaction also is caused long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.

Free radical is an unstable atom with a single electron on the outermost ring. Given its nature, free radical readily donate or intercept an electron from another atom, leading a chain of the free radical cascade that cannot be stopped until all single electron is paired or inhibited by antioxidants.

The antioxidant is a stable atom with a function to inhibit oxidation, come either from dietary sources or produced by the body.

Contrast to general belief, free radical is also needed in moderated amount for the function of the heart muscle to pump blood such as NO for vasodilation and increasing blood flow.

There is no single cause of oxidative stress. Some researchers suggested that a number of factors can facilitate the onset of oxidative stress, including cigarette smoke, oxidative burst from activated macrophages, particularly, the free radicals chain reaction.

Some researchers suggested that oxidative stress may also arise due to the chain reaction of free radicals in which free radicals donate or intercept an electron from other stable molecules.

Sadly, a prolonged period of oxidative stress presented in the human body can cause oxidative injury to biomolecules, (lipids, proteins, DNA) and the death of healthy cells through cytotoxicity.

Certain chronic diseases are found to be associated with oxidative stress, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.

On finding a natural ingredient for the prevention and treatment of chronic diseases, scientists examined the ultra-filtration extract from Danggui Buxue Decoction (EDBD) was able to protect cardiomyocytes from oxidative injury in an animal model.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to the results of myocardial cells from 1- to 2-day-old neonatal rats cultured in Dulbecco's modified Eagle's medium low-glucose and Ham's F12 medium (1:1), and the cellular injury induced by H(2)O(2), treatment of ultra-filtration extract mixture from Angelica sinensis and Hedysarum Polyporus at three doses of 3.75, 7.5, and 15 mg/mL.
* Protect the cardiomyocytes from H(2)O(2) injury in a dose-dependent manner (3.75, 7.50, and 15.00 mg/mL).

* Could significantly decrease LDH and CK leakages and intracellular MDA and MPO contents, increase SOD activity, up-regulate hsp70 expression, and down-regulate caspase-3 expression.

Based on the results, researchers suggest, "he EDBD has protection on cardiomyocytes injured by H(2)O(2) through improving cell antioxidant ability, up-regulating hsp70 expression, and inhibiting caspase-3 activity".

Taken altogether, herbal angelica may be considered an antioxidant remedy for the prevention of oxidative injury, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protection of ultra-filtration extract from Danggui Buxue Decoction on oxidative damage in cardiomyocytes of neonatal rats and its mechanism by Li YD1, Ma YH, Zhao JX, Zhao XK. (PubMed)

Devil's club (Oplopanax horridus) Gobbles Up Human Colorectal Cancer Cells in Vitro

By Kyle J. Norton

The colon-rectum formed a part of the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.

Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of cells DNA.

Colon cancer is relatively very common and slowly growing and progressing in a predictable way.

Most cases of primary colon cancer start in the cell on the surface of the inner lining of the colon. At the early stage. most patients with colon cancer do not experience any symptoms.

Rectal cancer is the slowest growing cancer. Therefore, most cases of colorectal cancer are diagnosed at the advanced stage in the older population.

According to the statistics provided by the American Cancer Society, in the US, colorectal cancer is the third most common cancer diagnosed in both men and women compared to other types of cancer.

The lifetime risk of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

Approximately, 140,000 cases of colorectal cancer were diagnosed in the US in 2018. Cancer also causes the death of over 50, 000 people, representing 8.3% of total cancer death.

Colorectal cancer is relatively very common and slowly growing and progressing cancer.

The disease is also the third most commonly diagnosed cancer in developed countries, including the US and Canada.

Being overweight or obese. smoking, physical inactivity, excessive alcohol drinking, the increase in age, family and personal history, genetic preposition are some of the prevalent risks of the disease.

Devil's Club is a large shrub, genus Oplopanax, belonging to the family Aralioideae, native to the cool moist forests of western North America. 

The herb has been used in traditional and herbal medicine as Adaptogen, Antipyretic, Pain Reliever, Antitussive, Antibacterial agent and to treat Arthritis, Diabetes, Colds, Cough, Sore throat, Chest congestion, Stomach pain, Constipation, Gall stones, Influenza, Cancer, etc.

On finding a potential compound for the treatment of cancer, researchers examined the low-toxic dichloromethane fraction of Oplopanax elatus, (OED) from the genus Oplopanax anticancer effects on colorectal cancer.

According to the tested analysis,

* The 5 μg/ml of OED combined with 40 μM of irinotecan possessed significant synergetic inhibition on SW-480 cells with a combination index (CI) of 0.56.

* The percentage of apoptotic cells was significantly increased from 69.57% (40 μM of irinotecan) or 72.7% (5 μg/ml of OED) to 95.6% after treatment of OED combined with irinotecan (OCI).

In other words, OED and irinotecan exerted a strong synergistic apoptotic effect against the tested cells by activating the protein associated with pro-apoptosis.

Based on the evidence, researchers said, "OED could enhance antiproliferative effects of irinotecan on colorectal cancer cells, which was related to the induction of apoptosis and regulations of activity of caspase-3".

Taken altogether, Devil's club may be considered a remedy for the treatment of colorectal cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Synergetic Inhibition of Human Colorectal Cancer Cells by Combining Polyyne-Enriched Fraction from Oplopanax elatus and Irinotecan by Wang J1,2, Shao L3, Wang CZ4, Zhou HH1,2, Yuan CS4, Huang WH. (PubMed)

Brassica Vegetables Reduce the Risk of Prostate Cancer

By Kyle J. Norton

The prostate warped around a tube (the urethra) is a gland of the male reproductive system found in front of the rectum and just below the bladder and responsible for making some of the semen that carries sperm.

The prostate gland is considered a reproductive organ in men.

Prostate cancer is a medical and chronic condition in which the cells of the prostate have become cancerous due to the alternation of the cell's DNA.

Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

Primary prostate cancer normally starts from the cell on the surface of the inner lining of the prostate tissue and gradually spreads to the deeper part of the prostate.

At the early stage, patients may not experience any symptoms, However, at the advanced stage, prostate cancer can induce symptoms of blood in the urine, frequent urination and urinary difficulty.

The cancer cells at this stage can also travel a distance away from the prostate to invade other healthy tissue and organ, leading secondary metastasis tumors.

According to the statistic, the 5-year survival rate for local and regional (stage 0 and 1) stages of prostate cancer is nearly 100%.

Believe it or not, more than 80% of prostate cancers are diagnosed in men who are 65 or older.

Therefore, men who are at higher risk of prostate cancer due to family history and increase in age and inherited gene changes should have their prostate gland checked annually.

On finding a potential plant that processes anti-cancer activity researchers examined the effects of Brassica vegetables, including mustard greens on prostate cancer risk.

According to the tested results
* Brassica vegetables exerted a strong effect on the metabolic breakdown products associated with the modulation of xenobiotic-metabolizing enzymes that protect DNA from damage.

According to the 12 published studies that analyze the relationship of Brassica vegetable intake and prostate cancer risk

* Three reported statistically significant reduced risks (P < 0.05) and one reported a borderline significantly reduced risk (P = 0.06) with high Brassica vegetable consumption.

* 6 showed a clear explanation of the prostate cancer risk involved in the consumption of Brassica vegetables.

Collectively, researchers said, " The epidemiological literature provides modest support for the hypothesis that high intakes of Brassica vegetables reduce prostate cancer risk".

Taken altogether, mustard greens may be considered a functional food for reducing the risk of prostate cancer, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence by Kristal AR1, Lampe JW. (PubMed)

Healthy Veggie Broccoli Inhibits the Onset and Progression of Diabetic Nephropathy induced by Cisplatin

By Kyle J. Norton

Kidneys are to bean-shaped organs located below the rib cage, one on each side of your spine with a function to filter out blood and remove waste through urinary secretion.

The kidney also plays a critical in maintaining the levels of fluids in the body, by removing extra fluids to make urine.

Furthermore, the kidney also regulates electrolytes, blood pressure, maintains acid-base balance, produces hormone calcitriol, renin, and erythropoietin.

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Long-term unmanaged hyperglycemia can damage the part of the kidneys thus reducing the kidney function in filter waste from the blood filters, leading to 'leaky' syndrome that allows protein into your urine.

Diabetic renal inflammation is a condition associated with inflammation in the development of diabetic nephropathy.

Diabetic nephropathy (Dn) is the 3 stages of kidney change in patients with diabetes. In this stage, patients may experience symptoms of abnormally elevated urinary albumin excretion, compared to the 15 and 300 μg/min in the baseline situation. 

Epidemiologically, diabetic nephropathy is also associated with cardiovascular disease and increases the mortality of diabetic patients.

Metabolic and hemodynamic alterations, oxidative stress, and activation of the renin-angiotensin system are some of the risk factors that have been found in patients with Dn.
The progression of diabetic nephropathy that leads to an increased rate in albumin excretion is higher in patients with increased blood pressure.

The condition in the advanced stage can lead to symptoms of worsening blood pressure, protein in the urine, swelling of feet, ankles, hands or eyes, increased need to urinate, loss of appetite, nausea and vomiting, fatigue and persistent itching.

In severe cases, patients may also experience symptoms of confusion or difficulty concentrating.

More importantly, if high blood pressure is left untreated, diabetic nephropathy can induce persistent proteinuria >0.5 g/ 24 h that furtherly declines the renal function with the mean fall rate being around 1 ml/min/mo.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The vegetable has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding a potential plant for the treatment of kidney diseases, researchers examined the effects of Sulforaphane (SFN), a natural constituent of cruciferous vegetables such as broccoli, Brussels sprouts, etc., on nephropathy.

In a rodent model of CIS-induced nephropathy, the administration of SFN
* Cisplatin triggered marked activation of stress signaling pathways and promoted cell death in the kidneys associated with attenuation of various prosurvival signaling pathways.

* Cisplatin also markedly enhanced inflammation in the kidneys.

The pretreatment of rodents with SFN demonstrated a significant attenuation of all parameters induced by the chemo drug. 

 
Moreover, the cisplatin-induced nephropathy is associated with activation of various cell death and proinflammatory pathways to cause renal injury was also inhibited by the injection of SFN.

Taken altogether, broccoli may be considered a functional food for the prevention and treatment of nephropathy, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane, a natural constituent of broccoli, prevents cell death and inflammation in nephropathy by Guerrero-Beltrán CE1, Mukhopadhyay P, Horváth B, Rajesh M, Tapia E, García-Torres I, Pedraza-Chaverri J, Pacher P. (PubMed)

Elder (Sambucus) Processes the Natural Immunomodulatory Property

By Kyle J. Norton

The immune system is the set of cells and their activity against antigens or infectious agents that comprise the body's defense system against diseases.

The immune system does a great job of keeping people healthy and preventing infections. Besides foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.

In normal immunity, active immunity may also be artificially acquired caused by the injection of the vaccine, a substance that contains antigen and passive immunity is an auto-response of immune system against infection through the production of antigen.

Immunomodulatory activity is an action that improves the underactive immune function that is susceptible to the invasion of the foreign microorganism and inhibits the overactive immune system that causes autoimmune diseases.

Depending on the substances that affect the immunomodulatory process, some may improve the immune function by modulating the genes involved immune responses and protect the immune system against toxins or immunotoxic effects such as abnormal allergic reactions, other such as heavy metals can induce opposite effects.

For example, curcumin (diferuloylmethane), found in the spice turmeric and processed anti-inflammatory, antioxidant, and chemopreventive activities may improve the immune system in the inhibition of cancer cell proliferation and overproduction of proinflammatory cytokines by target the genes associated with programming cell death and anti-inflammatory action and involved in the induction of these immune parameters.

On the other hand, toxic chemicals such as cadmium and lead accumulated in the body can have a negative impact on the immune defense by reducing the viability of both lymphocytes and macrophages was affected by heavy metals in a dose- and time-dependent manner.

On finding a natural ingredient for the improvement of immune functioning, scientists examined the immunomodulatory effects of bioactive compounds of Sambucus.

Elder or Common Elder, is a shrub or small tree of the genus Sambucus of 30 species, belonging to the family Adoxaceae, native to the temperate-to-subtropical regions of both the Northern Hemisphere and the Southern Hemisphere.

The herb has been used in traditional and herbal medicine to treat constipation, colic, diarrhea, colds, flu, bronchial and upper-respiratory, irritation of the skin, rheumatism, etc.

According to tested analysis from orally administrated with 2.8 mg.kg-1 BW of DMBA for ten times within a month with 7,12-dimethylbenz[a] anthracene (DMBA)-treated BALB/c mouse, followed by S. javanica berries and leaves extracts for 2 weeks.

* The expression of tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-ɣ) associated with the induction of inflammation were increased however after treated by S. javanica berries compared to that of leaves extracts that were significantly decreased.

* Furthermore, the DMBA-treated group showed an increase of necrosis incidence.

* Moreover, These increased was totally diminished with S. javanica extracts treatment.

Based on the results, researchers suggest, " these results suggested that S. javanica extracts have immunomodulatory activities to suppress inflammation and reduce necrosis incidence in experimental mice".

Taken altogether, Dandelion may be considered a remedy for the treatment of acute liver injury, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Immunomodulatory Activities of Sambucus javanica Extracts in DMBA-Exposed BALB/c Mouse by Putra WE1, Rifa'i M. (PubMed)