Herbal Angelica Inhibits the Parameters Associated with Anemia in Vivo

By Kyle J. Norton

Anemia is a condition of deficiency of hemoglobin, leading to not enough red blood cells in the body. The function of hemoglobin is to carry oxygen from the lung to the body' s cells.

Depletion of the stored iron can cause reduced hemoglobin production, leading to iron deficiency anemia.

Iron deficiency is simply as too little iron in the body for the production of hemoglobin. 

Anemia occurs when there isn't enough hemoglobin to transport oxygen to the body cells and organs need, leading to symptoms of irritability, fatigue, shortness of breath, low blood pressure, etc.

Approximately 2 out of 1000 people in Canada are considered an iron deficiency. 

Anemia can be classified into acute and chronic anemia
* Anemia due to chronic disease is a type of blood disorder as a result affected by one or more chronic medical condition(s), causing reduced red blood cell production.

** Microcytic, hypochromic anemia
Microcytic, hypochromic anemia is chronic anemia caused by many conditions including iron deficiency, Beta-Thalassemia trait, lead poisoning, chronic illness or inflammation, and sideroblastic anemia (Korones & Cohen, 1997; Wu et al., 2002)

** Macrocytic anemia
Macrocytic anemia is a condition of not having enough healthy red blood cells in the body to transport oxygen and nutrients to the body tissue and organ as a result of the insufficiency of vitamin B12.

** Normocytic anemia
Normocytic anemia is a common disease, occurring to men and women over 85 years old as a result of low red blood cell volume as a result of a decreased production of normal-sized red blood cells, and increased destruction or loss of red blood cells, deficiency of vitamin B6, B12, etc.

** Hemolytic anemia
Hemolytic anemia is a condition of not enough red blood cells in the blood, as a result of the premature destruction due to abnormal breaking down of red blood cells (hemolysis) either in the blood vessels or elsewhere in the body.

* Acute anemia denotes is short term drops of red blood red cell production. Most of the time, it is caused by heavy internal bleeding or blood loss due to injury. It is a serious problem, in most cases, it requires medical attention immediately.

On finding a natural ingredient for the prevention and treatment of diseases associated with red blood cells, scientists examined the effects of ganggui buxue tang (DGBX, Angelicae Sinensis, Radix Astragali and Rhizoma Coptidis) on anemia.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to the results of immune-induced AA mice used as an animal model, and the immunosuppressive agent, Ciclosporin A (CsA), was used as a positive control that was treated by the decoction,

* DGBX treatment significantly increased the production of whole blood cells in peripheral blood (PB); inhibit the expansion of Th1 and Th17 cells in the tested animals.

* Furthermore, DGBX increased the differentiation of Th2 and Tregs cells, regulated the expression levels of T-bet, GATA-3, RORγ in the immune cells, and pro-inflammatory cytokines, and decrease the expression levels of key molecules in the Jak/Stat signaling pathway involved in the process of immunity.

Collectively, DGBX can regulate the differentiation of T lymphocytes that orchestrates the immunosuppressive and hematogenic functions on AA mice against the onset of anemia.

Based on the results, researchers suggest, "DGBX might be a good candidate for inclusion in a randomized study for AA with more data on the possible side effects and doses used in humans".

Taken altogether, herbal angelica alone or combination with other herbal medicines may be considered anti-anemic remedy, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The herbal decoction modified Danggui Buxue Tang attenuates immune-mediated bone marrow failure by regulating the differentiation of T lymphocytes in an immune-induced aplastic anemia mouse model by Deng P1, Li X1, Wei Y1, Liu J2, Chen M3, Xu Y2, Dong B1, Zhu L1, Chai L. (PubMed)

Omega-3 Fatty Acids Result in Death of Ovarian Cancer Cells In Vitro

By Kyle J. Norton


Cancer is the class of chronic disease caused by irregular cell growth in the tissue or specific organ in the body due to the alternation of cell DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

The ovaries are oval-shaped ovum-producing reproductive organ formed part of women reproductive system that connects to the fallopian tubes and attaches to the outer layer of the uterus via the ovarian ligament. Usually, the left and right ovary take a turn to release an egg every month.

In other words, the main functions of the ovary play a critical role in producing oocytes (eggs) for fertilization and reproductive growth hormones, estrogen, and progesterone.

According to the statistics, ovarian cancer is one of the fifth most common cancer, accounting for more deaths than any other cancer of the female reproductive system in the US.

The lifetime risk of getting ovarian cancer is a woman is about 1 in 78.comapred to the lifetime of dying from ovarian cancer risk of 1 in 108.

The exact causes of ovarian cancer are not identified. However, epidemiological studies suggested that women who have endometriosis, genetic preposition such as BRCA1 and BRCA2 gene, acquired genetic mutation such as the TP53 tumor suppressor gene are susceptible to the substantial risk of the development of the disease.

Besides sharing the common symptoms of other types of cancer, most ovarian cancer patients may experience symptoms of discomfort in the pelvic area, changes in bowel habits, such as constipation. and a frequent need to urinate.

According to the statistics provided by the Canadian Cancer Society, in Canada, the 5-year net survival for ovarian cancer is 45%. 

In other words, on average,  45% of women diagnosed with ovarian cancer will survive for at least 5 years.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of cancer, researchers investigated the effect of OM-3FAs on epithelial ovarian cancer cell lines.

According to the results of 3 epithelial ovarian cancer cell lines (SKOV-3 [p53 null], TOV-21G [wt p53] and OVCAR-3 [mutant p53]) and one immortalized ovarian surface epithelial cell line (IOSE-29 [wt p53]) treated with OM-3FAs, OM-3FAs showed a statistically significant inhibitory effect in all four cell lines.

Furthermore, in the p53 null and mutant cell lines, SKOV-3 and OVCAR-3, the application of OM-3FAs showed inhibitory activity without inducing apoptosis and down-regulated expression of VEGF.

However, the apoptosis and/or VEGF down-regulation was strongly evident in the wt p53 cell lines TOV-21G and IOSE-29.

Collectively, researchers said, "under the influence of OM-3FAs, there are definitive growth-suppressive mechanisms at work and that the biologic effects of OM-3FAs may in part be mediated by the p53 status".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the treatment of ovarian cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The effects of Omega-3 fatty acids on growth regulation of epithelial ovarian cancer cell lines by Sharma A1, Belna J, Logan J, Espat J, Hurteau JA. (PubMed)
(2) Intake of omega-3 and omega-6 fatty acids and risk of ovarian cancer by Ibiebele TI1, Nagle CM, Bain CJ, Webb PM. (PubMed)

Leeks (Allium ampeloprasum) Induce Cancer Cell Death in Vitro

By Kyle J. Norton

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Angiogenesis is the process that develops new blood vessels from pre-existing vessels by invasive tumors to provide energy(nutrition and fluids) for cancerous cells growth and proliferation.

Cancers are the second leading cause of death worldwide besides heart diseases.

The most common types of cancer in Canada include lung, colorectal, breast and prostate cancers. And these 4 cancers are account for half of all cancers diagnosed in Canada.

Leek is a genius of Allium, belonging to the vegetable family vegetable Alliacaea, the same as onion and garlic. Leeks are easy to grow from seed and usually reach maturity in the autumn months, and have few pest or disease problems.

On finding a potential plant that processes anti-tumor growth activity researchers compared the anticancer properties various sulfur and organic compounds like S-allyl mercaptocysteine, quercetin, flavonoids, and ajoene on cancer.

According to the analysis,

* These compounds with various mechanisms such as hindering cell cycle, inhibiting signaling pathways, inducing apoptosis, and antioxidant activity interfere with diverse stages of formation, growth, differentiation, and metastasis of cancer cells.

* Similar to garlic and onion, other species such as leeks have exhibited anticancer activities, so that active natural molecules extracted from them might serve as possible anticancer agents.

Collectively, researchers said, "In this review, we aim to summarize the available data on anticancer mechanisms of 16 species of Allium genus and their major compounds to assist further researches on the treatment and prevention of cancers".

Taken altogether, leeks may be considered a functional food for the prevention and treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Allium vegetables for possible future of cancer treatment by Asemani Y1, Zamani N2, Bayat M1, Amirghofran Z. (PubMed)

Angelica Sinensis Induces Bladder Cancer Cell Death

By Kyle J. Norton

The bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excreted them through the urethra.

Bladder cancer is the most common type of cancer that affects men twice as frequently as it affects women.

Usually, cancer starts from the lining of the bladder caused by several types of malignant growths of the urinary bladder cells. However, after growing large enough, the cancerous call can spread to other regions in the body through the circulation of fluids and blood.

According to the statistic. 90% of bladder cancer were diagnosed in people who are older than 55. and the average age of people are diagnosed with bladder cancer is 73.

Every year, the disease causes over 17,000 deaths and bladder cancer is the eighth most common cause of cancer death in men.

According to the statistic, men are 4 times more likely than women to be diagnosed with the disease.

Out of the many causes of bladder cancer, researchers found that lifelong smoking, aging, and chronic bladder inflammation are some of the most common prevalent risk factors of bladder cancer cases found in the Western world.

Bladder cancer can be classified into 2 types,

* Superficial types of bladder cancer
This type of bladder cancers has a characteristic of often recurrence but usually non-invasive. It can be controlled or removed by regular cystoscopy.

*Invasive types of bladder cancer.

Invasive types of bladder cancer tend to spread after beginning in cells in the lining of the bladder. It often requires surgery by removing part or the whole bladder.

On finding a natural ingredient for the prevention and treatment of cancer, scientists examined the anti bladder cancer activity of N-butylidenephthalide (BP) isolated from Radix Angelica Sinensis (Danggui) both in vivo and in vitro.

  Angelica or Dang Gui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to tested analysis,
* The administration of BP caused bladder cancer cell death in a time- and dose-dependent manner and induced apoptosis via the activation of pro-apoptotic proteins caspase-9 and caspase-3.

* Furthermore, BP also suppressed the migration of bladder cancer cells, revealed by the trans-well and wound healing assays.

* In vitro, BP up-regulated the tumor suppressor E-cadherin and down-regulation of N-cadherin involved in cancer metastasis and increase tumor cell proliferation.

* Moreover, BP also suppressed BFTC xenograft tumor growth and caused a 44.2% reduction of tumor volume after treatment for 26 days.

* Most importantly, in combination with BP, the sensitivity of these bladder cancer cells to cisplatin increased significantly.

Based on the results, researchers suggest, "The incidence of bladder cancer decreased in patients who were exposed to Angelica sinensis, suggesting that BP could serve as a potential adjuvant in bladder cancer therapy regimen".

Taken altogether, Angelica may be considered a remedy for the treatment of bladder cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antiangiogenic activity of phthalides-enriched Angelica Sinensis extract by suppressing WSB-1/pVHL/HIF-1α/VEGF signaling in bladder cancer by Chen MC1, Hsu WL2,3, Chang WL4, Chou TC. (PubMed)
(2) Potential therapeutic effects of N-butylidenephthalide from Radix Angelica Sinensis (Danggui) in human bladder cancer cells by Chiu SC1,2,3, Chiu TL4, Huang SY5, Chang SF1, Chen SP6, Pang CY7,8, Hsieh TF. (PubMed)

Devil's Claw (Harpagophytum procumbens) Processes Strong Antioxidant Properties

By Kyle J. Norton

Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.

In other words, antioxidants inhibited the onset of free radical before they can cause a chain reaction in facilitating the protein, lipid, and cell damage.

Antioxidants can either produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.

However, in people with a weakened immune system, intake dietary sources of antioxidants may be necessary.

Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.

This chain of reaction is the cause of oxidative stress, a condition is associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.

Overexpression of free radicals is known to cause damage in contributing to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataracts, and cancer.

Oxidative stress is a result of an imbalance of the ratio of free radicals and antioxidants in the body.

On finding a natural ingredient for the prevention and treatment of chronic inflammatory diseases, scientists examined the antioxidative reparations from the dried tubers of Harpagophytum procumbens (Burch.) DC ex Meisn, commonly known as devil's claw on joint pain and inflammation in patients suffering from rheumatic and arthritic disorders.

Devil's claw also known as the wood spider, is a plant of genus Harpagophytum in the family of Pedaliaceae, native to South Africa. 

The plant has been used as an herb in traditional and herbal medicine to treat fever, rheumatoid arthritis, skin, gallbladder, pancreas, stomach and kidneys conditions, etc.

According to the chemical analysis of the content of specialized metabolites in the three samples,
* Harpagoside, the main compound, followed by the two isomers acteoside and isoacteoside exerted a significant antioxidant capacity at the IC 50 concentration compared to others.

*More importantly, other chemical differentiation on antioxidant capacities such as 2,2'-di-phenyl-1-picrylhydrazyl (DPPH) and 2.2'-azin-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) methods also resulted in very similar IC50 values.

* Most importantly, researchers also found that a higher ferric in the extract showed to reduce antioxidant ability. 

In other words, Devil's claw processes a number of antioxidants that play a critical role in decreasing the symptoms of patients suffering from rheumatic and arthritic disorders.

Based on the results, researchers suggest, " the two preparations could generally maintain good stability and biological activity at least for the four years from the production to the expiration date.".

Taken altogether, Dandelion may be considered a remedy for the treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Quality Assessment of Commercial Spagyric Tinctures of Harpagophytum procumbens and Their Antioxidant Properties by Avato P1, Argentieri MP. (PubMed)

Herbal Elder (Sambucus), a Natural Antioxidant Remedy

By Kyle J. Norton

Antioxidants are stable molecules that inhibit oxidation induced by free radicals.

Some foods are antioxidants producers such as fruits and vegetables and whole-grain, while others such as processed meats, alcohol are radicals producers. Particularly, fats and oils can easily be oxidized if they are cooked in high heat.

A free radical is a highly reactive atom with a single electron in the outer ring.

Free radicals produced in our body are a natural process derived either from essential metabolism through the processes of food intake or from external sources through directly contacting the skin or the air we breathe including exposure to X-rays, ozone, cigarette smoking, air pollutants, and industrial chemicals.

In order to counter the overexpression of free radicals which add to the body's burden. However,  our body produces enzymes antioxidants and metal carrier proteins to neutralize them before they can cause damage.

Depending on the degrees of free radical invasion, antioxidant enzymes can be categorized into first, second, third and even fourth line of defense.

Oxidative stress is a result of the imbalance of free radicals and antioxidants in the body. The syndrome is either caused by overexpression of free radicals or depressed levels of antioxidants or both.

Oxidative stress has been found to induce widespread damage due to a set of a chain reaction auto-catalytically by free radicals that attacks the lipid bilayers of the cell walls, induces lipid, protein damage and alternation of cell DNA, leading to the onset of chronic diseases, including cancers.

On finding a natural ingredient for the prevention and treatment of diseases of oxidative stress, scientists compared the chemical profile that induces the antityrosinase and antioxidant activities of ethanol (EtOH) and methanol (MeOH) extracts of Sambucus nigra L. (Adoxaceae) flowers and leaves

Elder or Common Elder, is a shrub or small tree of the genus Sambucus of 30 species, belonging to the family Adoxaceae, native to the temperate-to-subtropical regions of both the Northern Hemisphere and the Southern Hemisphere.

The herb has been used in traditional and herbal medicine to treat constipation, colic, diarrhea, colds, flu, bronchial and upper-respiratory, irritation of the skin, rheumatism, etc.

According to the results of a novel lower-melting-point ethylene-chlorotrifluoroethylene (LMP ECTFE) nanofiltration (NF) membrane was employed to produce the concentrated fractions of S. nigra., the NF retentate fractions of floral ethanol extracts exerted the highest tyrosinase inhibitory activity with an IC50 of 53.9 µg/mL and the highest ABTS radical scavenging activity (IC50 of 46.4 µg/mL).

The major chemical compounds that exert the aforementioned activity, according to the performance liquid chromatography (HPLC) profile were rutin, quercetin, protocatechuic acid, 3,5-dicaffeoylquinic acid, and neochlorogenic acid.

Based on the results, researchers suggest, " ...the present investigation revealed the potential benefits of NF application in S. nigra extracts processing, suggesting the use of retentate fractions as a promising source for antioxidant and tyrosinase inhibitory compounds which could pave the way for future applications".

Taken altogether, Dandelion may be considered an antioxidative remedy for the treatment of diseases induced by oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Flower and Leaf Extracts of Sambucus nigra L.: Application of Membrane Processes to Obtain Fractions with Antioxidant and Antityrosinase Properties by Tundis R1, Ursino C2, Bonesi M3, Loizzo MR4, Sicari V5, Pellicanò T6, Manfredi IL7, Figoli A8, Cassano A. (PubMed)

Elecampane (Inula helenium) May Be Used for the Inhibition of Oxidative Stress-Related Human Diseases

By Kyle J. Norton

Oxidative stress is a medical condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissue.

Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.

This chain of reaction is the cause of oxidative stress, a condition is associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.

Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.

In other words, antioxidants inhibited the onset of free radical before they can cause a chain reaction in facilitating the protein, lipid and cell damage.

Antioxidants can either produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.

In some cases, this reaction also is caused long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.

There is no single cause of oxidative stress. Some researchers suggested that a number of factors can facilitate the onset of oxidative stress, including cigarette smoke, oxidative burst from activated macrophages, particularly, the free radicals chain reaction.

Sadly, a prolonged period of oxidative stress presented in the human body can cause oxidative damage to biomolecules, (lipids, proteins, DNA) and the death of healthy cells through cytotoxicity.

Certain chronic diseases are found to be associated with oxidative stress, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.

On finding a natural ingredient for the prevention and treatment of diseases involved in oxidative stress, scientists examined the effects of secondary metabolites from Inula species on the oxidative stress-related diseases.

Elecampane, also known as Horse-heal (Inula helenium) is a perennial composite plant, genus nulla, belonging to Asteraceae, native to Southern Europe, and Asia. 

The plant has been used in traditional and herbal medicine in treating bronchitis or emphysema, night sweats, pulmonary tuberculosis, irritating cough, catarrhal discharges, etc.

According to the search of the database of medical literature from Scopus, PubMed, and Web of Science, that identified more than 120 articles are reviewed, highlighting the most active compounds with special emphasis on the elucidation of their antioxidative-stress mechanism of action,

* Alantolactone found in Elecampane was the most polyvalent compound, reporting interesting EC50 values for several bioactivities that showed an effect on on the oxidative stress-related diseases.

* 1-O-acetylbritannilactone also found in Elecampane was found to be a promising lead compound for the development of analogs with interesting properties.

Based on the results, researchers suggest, "The Inula genus is a good bet as a source of structurally diverse compounds with antioxidant activity that can act via different mechanisms to fight several oxidative stress-related human diseases, being useful for the development of new drugs".

Taken altogether, Elecampane processed abundantly Alantolactone and 1-O-acetylbritannilactone and may be considered a remedy for the treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inula L. Secondary Metabolites against Oxidative Stress-Related Human Diseases by Tavares WR1, Seca AML.(PubMed)