Tuesday, 14 April 2020

Healthy Food Cabbage Protects the Liver Against Injury

By Kyle J. Norton

The liver is the largest internal organ in the human body, played an essential role in filtering blood from the intestine before passing them to other parts of the body.

The organ also produced cholesterol, a waxy substance that is needed to aid digestion and build strong cell membranes, production of steroid hormones and vitamins.

Liver injury may be a result caused by physical impact or penetrating trauma. In some cases, liver injury can also be induced by toxicity, leading to acute liver injury.

Liver injury can be mild or severe. In a mild case, liver injury can recover itself. However, in severe cases. surgery to stop the bleeding and remove the part of injury may be necessary.

According to the statistics, liver injury has been found to constitute 5% of all traumas, making it the most common abdominal injury.

Other most common symptoms associated with liver injury are shocks due to severe bleeding inducing a rapid heart rate, rapid breathing, and cold, clammy, pale or bluish skin.

In some cases, blood accumulated in the abdomen may irritate the abdominal tissue, leading to symptoms of abdominal pain and swollen and tenderness.

The severity of a liver injury can be diagnosed by computed tomography (CT) or ultrasonography.

Depending on the size of the wound, most cases of liver injury are healed by itself. However, in severe cases, hospitalization may be necessary if the bleeding does not stop.

The most common cause of liver injury is an overdose of medicine which has been found to be the number 1 factor.

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.

On findings a natural wholefood for the improvement of liver diseases, researchers examined the hepatoprotective properties of the essential oil (EO) from white cabbage.

On acute carbon tetrachloride (CT)-induced liver damage,
* Bocfal EO contained organic polysulphides (OPSs), such as dimethyl trisulphide (DMTS) 65.43 ± 4.92% and dimethyl disulphide (DMDS) 19.29 ± 2.16% as major constituents.

* Bocfal EO and DMTS were found to be potent TBARS, a byproduct of lipid peroxidation inhibitors with IC50 values of 0.51 and 3 mg/L, respectively.

* Bocfal EO demonstrated better hepatoprotective properties than did DADS (p < 0.05), although both slightly affected the hepatic parenchyma per se.

Based on the findings, researchers said, "The antioxidant properties of Bocfal EO and DMTS may be the mechanism of hepatoprotective action; the parenchymal disturbances by Bocfal EO or DADS alone may be related to the high doses used".

Taken altogether, cabbage process anti liver injury, pending to the confirmation of the larger sample size and multicenter human study.




Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Evaluation of antioxidant and hepatoprotective effects of white cabbage essential oil by Morales-López J1, Centeno-Álvarez M2, Nieto-Camacho A3, López MG4, Pérez-Hernández E5, Pérez-Hernández N1, Fernández-Martínez E. (PubMed).

Healthy Veggie Broccoli Processes Anti-Hypercholesterolemic Property

By Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.

The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes and produces vitamin D and steroid hormones.

Hypercholesterolemia is a condition characterized by abnormally high levels of cholesterol in the bloodstream.

In other words, the condition is caused by either overexpression of low-density lipoprotein (LDL) or low levels of high-density lipoprotein (HDL).

Cholesterol, a waxy substance produced by the liver or the dietary in moderate amount source plays a critical to aid digestive function in absorbing nutrients, build strong cell membranes, produce steroid hormones and vitamin D. However, excessive amounts in the blood have been found to induce plaque built-up on the arterial wall, leading to heart disease and stroke.

Similar to high blood pressure, people with hypercholesterolemia are asymptomatic. Patients with familial hyper cholesterol may experience symptoms of chest pain with activity. xanthomas, and cholesterol deposits around the eyelids.

The most common complications associated with uncontrolled hypercholesterolemia are carotid artery disease, coronary heart disease, including angina or heart attack, peripheral artery disease, and stroke.

The most common complications associated with uncontrolled hypercholesterolemia are carotid artery disease, coronary heart disease, including angina or heart attack, peripheral artery disease, and stroke.

According to the statistics provided by the CDC, hypercholesterolemia is a major risk factor of heart disease, a leading cause of death in the US. In the US, approximately, 71 million American adults (33.5%) have high low-density lipoprotein (LDL), or “bad,” cholesterol, and only 1 out of every 3 adults with high LDL cholesterol has the condition under control.

Sadly, only 50% of people hypercholesterolemia are getting treatment.

Out of many risk factors associated with the risk of hypercholesterolemia, some researchers suggested that widespread obesity due to aging may have a strong impact on the increased incidence in the US.


Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The vegetable has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding a potential plant that processes anti-high blood cholesterol, researchers examined a diet rich in high glucoraphanin (HG) broccoli that reduces plasma LDL-C.

130 volunteers recruited to two independent double-blind, randomly allocated parallel dietary intervention studies, were assigned to consume either 400 g standard broccoli or 400 g HG broccoli per week for 12 weeks. 

According to the plasma lipids before and after the intervention, 
* In one study, The HG broccoli diet reduced plasma LDL-C by 7.1% (95% CI: –1.8%, –12.3%, p = 0.011), whereas standard broccoli reduced LDL-C by 1.8% (95% CI +3.9%, –7.5%, ns). In study 2 (93 volunteers)

*  In another study, the HG broccoli diet resulted in a reduction of 5.1% (95% CI: –2.1%, –8.1%, p = 0.001), whereas standard broccoli reduced LDL-C by 2.5% (95% CI: +0.8%, –5.7%, ns). 

* When data from the two studies were combined the reduction in LDL-C by the HG broccoli was significantly greater than standard broccoli (p = 0.031).

Collectively, researchers said, "Evidence from two independent human studies indicates that consumption of high glucoraphanin broccoli significantly reduces plasma LDL-C".

Taken altogether, broccoli may be considered a functional food for the prevention and treatment of hypercholesterolemia, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Diet rich in high glucoraphanin broccoli reduces plasma LDL cholesterol: Evidence from randomised controlled trials by Charlotte N Armah,1 Christos Derdemezis,2 Maria H Traka,1 Jack R Dainty,1 Joanne F Doleman,1 Shikha Saha,1 Wing Leung,1 John F Potter,3 Julie A Lovegrove,2 and Richard F Mithen. (PubMed)

Monday, 13 April 2020

Herbal Angelica Inhibits the Onset of Male Infertility

By Kyle J. Norton

Infertility is a condition of the inability of a couple to conceive after 12 months of unprotected sexual intercourse.

The condition affects over 5 million couples alone in the U. S. and many times more in the world. Because of unawareness of treatments, only 10% seek help from a professional specialist.

Infertility is very common in the US, approximately 10% of women or 6.1 million, ages 15-44 have difficulty getting pregnant or staying pregnant, according to the Centers for Disease Control and Prevention (CDC).

Male infertility refers to a male's inability to cause pregnancy in a fertile female, accounting for  40–50% of infertility.

The condition affects approximately 7% of all men. 

The most common causes of male infertility are deficiencies in the semen, and semen quality.

In men, age, pesticide and chemical exposure, drug use, radiation, pollution, cigarette or marijuana smoke, heavy alcohol consumption may be some risk factors for the onset of infertility.

In fact, some unfertilized women and men sometimes ago are fertile. However, here are some reasons that have found to increase the risk of infertility in the Western world, including
* Persuade a personal career, before having children.

*Try to be financial stability before having children.

* Too young to be a parent, raising a child needs efforts, time and money.

* Enjoy the couple childless years before committing.

Some researchers suggested that the widespread obesity in North America may be the major factor correlated to the increased infertile rate over the past few decades.

On finding a natural ingredient for the prevention and treatment of infertility, scientists examined the effects of decursin extracted from Angelica Gigas Nakai on antioxidant activity in vitro and in a cryptorchidism-induced infertility rat model.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to the results of the differentiation of rats treated either by distilled water or AG 400 mg/kg of A. gigas extract after 1, 2, and 4 weeks, treatment group with A. gigas extract
* Protected TM3 cells against oxidative stress in a dose-dependent manner,

* Improved the mean weight of the cryptorchid testis,

* Maintained sperm counts, motility, and spermatogenic cell density,

* Decreased levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and increased levels of superoxide dismutase (SOD),

* Significantly increased Nrf2 and heme oxygenase-1 (HO-1), and

* Significantly decreased apoptosis.

These results suggested, "decursin extracted from A. gigas is a supplemental agent that can reduce oxidative stress by Nrf2-mediated upregulation of HO-1 in rat experimentally induced unilateral cryptorchidism and may improve cryptorchidism-induced infertility".

Taken altogether, herbal angelica may be considered an antioxidant remedy for the treatment of oxidative induction of male infertility, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective Effect of Decursin Extracted from Angelica gigas in Male Infertility via Nrf2/HO-1 Signaling Pathway by Woong Jin Bae, U. Syn Ha, [...], and Sae Woong Kim. (PMC)

Herbal Eyebright ( Euphrasia), a Potential Anti-inflammatory Herbal Medicine

By Kyle J. Norton

Anti-inflammation is a process that inhibits the pro-inflammatory cytokines without affecting the immune system activity against pathogens.

Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.

Truly, the main focus of inflammation is to repair damage and injury.

Acute inflammation occurs quickly or within the hours and lasts a few days or weeks and the damaged tissues are healed themselves after all pathogens are killed off.

Any inflammation that lasts more than 8 weeks is considered chronic inflammation.

Chronic inflammation is a low-grade inflammation caused by the inability of the immune system to eliminate the invasive pathogens that occurred in the acute phase of infection.

Believe it or not, worldwide, 3 of 5 death are results from chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes.

In the US, chronic inflammatory diseases affect more than 50 million Americans each year.

Diseases associated with low-grade inflammation include diabetes and cardiovascular.

Conventionally, Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common medical drugs such as aspirin. ibuprofen in reducing inflammation associated with pain-relieving.

On finding a natural ingredient for the prevention and treatment of inflammatory diseases, scientists examined the extract of Euphrasia officinalis, a traditional folk medicine synthesized gold nanoparticles (EO-AuNPs) anti-inflammatory effects.


Eyebright is one of the species of flowering plants, genus Euphrasia, belonging to the family Orobanchaceae, native to Europe. 

The plant has been used in traditional and herbal medicine to treat eye infection and to relieve inflammation caused by colds, coughs, sinus infections, sore throats, and hay fever.

According to tested analysis,
* EO-AuNPs exhibited little cytotoxicity in RAW 264.7 cells at 100 µg/mL concentration after 24 hours.

* EO-AuNPs significantly suppressed the LPS-induced release of pro-inflammatory expressions such as NO, TNF-α, IL-1β, and IL-6.

* Furthermore, pretreatment with EO-AuNPs significantly reduced the phosphorylation and degradation of inhibitor kappa B-alpha and inhibited the nuclear translocation of NF-κB p65 against the activation of inflammatory proteins and immune response.

Based on the results, researchers suggest, "The synthesized EO-AuNPs showed anti-inflammatory activity in LPS-induced RAW 264.7 cells, suggesting they may be potential candidates for treating inflammatory-mediated diseases".

Taken altogether, Eyebright may be considered a remedy for the treatment of inflammatory diseases, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Green synthesis of gold nanoparticles using Euphrasia officinalisleaf extract to inhibit lipopolysaccharide-induced inflammation through NF-κB and JAK/STAT pathways in RAW 264.7 macrophages by Liu Y1, Kim S2, Kim YJ1,2, Perumalsamy H2, Lee S3, Hwang E4, Yi TH. (PubMed)

Sunday, 12 April 2020

Omega-3 Fatty Acids Improve Patients with Heart Failure

By Kyle J. Norton


The heart is a four-chambered, hollow muscle and a double-acting pump located in the chest between the lungs is a muscular organ in the human body.

The heart formed an important part of the circulatory system that pumps blood through the blood vessels to nourish the body and assist in the removal of metabolic wastes.

According to the statistic provided by the American Heart Foundation, on average, an American dies of CVD every 38 seconds. Cardiovascular disease (CVD) accounted for 840,678 deaths in the US in 2016 and the condition also claims more lives each year than all forms of cancer and chronic lower respiratory disease combined

In 2016, cardiovascular diseases cause the death of 2,303 deaths each day, in the US.
Coronary heart disease (CHD) kills over 370,000 people annually.

The most common heart disease in North America is CHD, the type of heart disease caused by plaque buildup on artery walls, leading to narrow, thickens and stiffens arteries. Some researchers suggested that the causes of plaque build-up on the arterial wall were the results of several factors including an unhealthy diet, lack of exercise, being overweight and smoking.

Heart failure (HF) is a medical condition associated with the reduced function of the heart muscle that can not maintain blood flow to meet the body's needs, leading to symptoms of 
* Shortness of breath and excessive tiredness are caused by the congestion in your lungs in the process of inhaling oxygen and exhaling carbon dioxide.
And
* Leg swelling is a condition caused by fluid to back up in your lungs and in other parts of your body such as your ankles.

Believe it or not, approximately 600, 000 Canadian are living with heart failure or 16% of the entire population.

Conventionally, there is no cure for heart failure, the most common treatment is focusing on lifestyle changes and managing the condition to improve quality of life.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of heart diseases, researchers examined the effects of long-chain omega-3 fatty acid supplementation on omega-3 levels on chronic heart failure (CHF).

The randomized, double-blind, placebo-controlled pilot clinical trial included a total of 108 patients with CHF from June 12, 2014, to May 19, 2016; 80 (74.1%), using a 400/200 eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) fish oil at 2 g and an almost pure EPA at 2 g daily, compared with a matched placebo for 12 weeks for patients with CHF and major depressive disorder.

Based on the results of differentiation,
* Omega-3 supplementation resulted in significant increases in omega-3 levels in red blood cell counts, corresponding to a particular compound of omega-3.

* Changes in cognitive depressive symptoms and social function were in favor of the omega-3 supplementation.

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention of heart failure, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Long-Chain Omega-3 Fatty Acid Supplements in Depressed Heart Failure Patients: Results of the OCEAN Trial by Jiang W1, Whellan DJ2, Adams KF3, Babyak MA4, Boyle SH4, Wilson JL4, Patel CB5, Rogers JG5, Harris WS6, O'Connor CM. (PubMed)

Tocopherols, the Promising Anti Colon Cancer Phytochemicals

By Kyle J. Norton

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

The colon also is known as the large bowel or large intestine, formed parts of the digestive system in our body.

The colon consists of four parts: descending colon, ascending colon, transverse colon, and sigmoid colon.

The main functions of the colon are to reabsorb fluids and process waste products from the body and prepare for its elimination.

Colon cancer is a chronic condition caused by cell growth irregularly and disorderly in the colon due to the alternation of DNA.

Most cases of colon cancer start in the cells on the surface of the inner lining of the colon. At this stage, patients may not experience any symptoms.

After penetrating deeper into the colon layer, the cancer cells may travel a distance away to infect other healthy tissues and organs through the fluids and blood circulation.

According to the statistics provided by the Stat-Canada, 1 in 16 Canadian men and 1 in 18 women will develop colorectal cancer over their lifetime. The cancer is the third leading cause of death behind prostate and lung cancer.

Every year, approximately 26,,000 Canadians are diagnosed with colorectal cancer, represented 13% of all new cancer cases.

Colon cancer is a slow growth cancer, therefore, most colon cancer is detected in the later stage after experiencing symptoms of blood in your stool or an ongoing change in bowel habits. In other words, only 39% of colorectal cancer is detected in the early stage.

The 5-year survival rate of localized stage colorectal cancer is 90%.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of digestive diseases, researchers examined the growth inhibitory effects of different forms of tocopherols (T), tocopheryl phosphates (TP), and tocopherol quinones (TQ) on human colon cancer HCT116 and HT29 cells.

According to the analysis,
* δ-T was more active than γ-T in inhibiting colon cancer cell growth, decreasing cancer cell colony formation, and inducing apoptosis observed on the tested cancer cell lines compared to the ineffective α-T.
* Furthermore, the rate of cellular uptake also followed the ranking order δ-T > γ-T ≫ α-T. TP and TQ generally had higher inhibitory activities than their parent compounds.
* Moreover, the γ forms of TP and TQ were more active than the δ forms in inhibiting cancer cell growth, whereas the α forms were the least effective.

* More importantly, the potencies of γ-TQ and δ-TQ (showing IC50 values of ∼0.8 and ∼2 μM on HCT116 cells after a 72 h incubation, respectively) were greater than 100-fold and greater than 20-fold higher, respectively, than those of their parent tocopherols.

The efficacy of δ-T, γ-TP, and γ-TQ in the Induction of cancer cell apoptosis by was characterized by the cleavage of caspase 3 and PARP1 and DNA fragmentation associated with cancer cell death.
 

After talking about other factors into account, researchers said, "These studies demonstrated the higher growth inhibitory activity of δ-T than γ-T, the even higher activities of the γ forms of TP and TQ, and the ineffectiveness of the α forms of tocopherol and their metabolites against colon cancer cells".

Taken altogether, tocopherols may be considered an adjunct therapy in the treatment of colon cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibitory effects of different forms of tocopherols, tocopherol phosphates, and tocopherol quinones on growth of colon cancer cells by Dolfi SC1, Yang Z, Lee MJ, Guan F, Hong J, Yang CS. (PubMed)
(2) δ- and γ-tocopherols inhibit phIP/DSS-induced colon carcinogenesis by protection against early cellular and DNA damages by Chen JX1, Liu A1, Lee MJ1, Wang H1, Yu S1, Chi E1, Reuhl K2, Suh N1,3, Yang CS. (PubMed)

Saturday, 11 April 2020

Broccoli' Sulforaphane (SFN), a Natural Chemo-Preventive Phytochemical

By Kyle J. Norton

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
Chemo-drugs are a class of conventional medicine used for the treatment of cancers. including 5-fluorouracil, 6-mercaptopurine, cytarabine, gemcitabine, and methotrexate.

Compared to other treatments, chemotherapy targets cancer's specific genes, proteins, or the tissue environment that contributes to cancer growth and survival.

Chemo drugs have been found to improve the survival rate of cancer patients. However, they also induce significant side effects.

The most common side effects of chemo-drugs are fatigue, hair loss, easy bruising, and bleeding. infection, anemia (low red blood cell counts) nausea and vomiting, appetite changes and constipation.

The side effects of chemo drugs are the results of damage to the healthy blood-forming cells in the bone marrow, hair follicles, and cells in the mouth, digestive tract, and reproductive system.

According to the American Cancer Society, some chemo drugs have also been found to damage cells in the heart, kidneys, bladder, lungs, and nervous system.

Chemoprevention is the use of a medication, vitamin or supplement to prevent the initiation of cancer.

On finding a potential plant for the treatment of cancers, researchers compared the effects of
Brassica family of cruciferous vegetables such as broccoli is a rich source of isothiocyanates, sulforaphane (SFN) as chemopreventive phytochemical.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

According to the differentiation, sulforaphane (SFN) exerted its potent chemopreventive agent based on its ability to target multiple mechanisms within the cell to control carcinogenesis.

More precisely, anti-inflammatory, pro-apoptotic and modulation of histones are some of the more important and known mechanisms by which SFN demonstrates chemoprevention.

Furthermore, The effect of SFN on cancer stem cells is another area of interest that has been explored in recent years and may contribute to its chemopreventive properties.

Based on the results, researchers said, "In this paper, we briefly review structure, pharmacology and preclinical studies highlighting chemopreventive effects of SFN".

Taken altogether, broccoli consists of SFN may be considered a chemopreventive functional food, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The role of Sulforaphane in cancer chemoprevention and health benefits: a mini-review by Bayat Mokhtari R1,2,3,4, Baluch N5, Homayouni TS6, Morgatskaya E6, Kumar S6, Kazemi P6, Yeger H. (PubMed)https://www.ncbi.nlm.nih.gov/pubmed/28735362