Healthy Food Broccoli's Sulforaphane (SFN) Protects Diabetics Against the Onset of Diabetic Cardiomyopathy Through Nrf2

By Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Most common types of diabetes are
* Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form diabetes found in children is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutation and some viruses.

As of today, there is no cure for type 1 diabetes. Treatment is focusing on managing blood sugar levels with insulin injection, diet, and lifestyle change.

* Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate the glucose due to either cell
Diabetic cardiomyopathy is a complication found in patients with diabetes associated with reducing the heart function in circulating blood through the body, leading to heart failure and increased the accumulation of fluid in the lungs.

Diabetic cardiomyopathy is classified into different types, depending on the damage that has been affected, including
* Microangiopathy is a disorder that affects small blood vessels, leading to impaired myocardial blood flow reserve.

* Autonomic neuropathy is a disorder that affects the nerves that manage everyday body functions, leading to abnormal blood pressure, heart rate.

* Endothelial dysfunction is a disorder associated with the damage of vascular endothelium. The condition is considered an early event of cardiovascular disease.

The most common causes of diabetic cardiomyopathy are myocardial dysfunction in the absence of overt clinical coronary artery disease, valvular disease, and other conventional cardiovascular risk factors, such as hypertension and dyslipidemia.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

With an aim to find a natural food for the prevention and treatment of heart diseases, researchers examined the effect of sulforaphane, an active compound and an Nrf2 activator found in broccoli on diabetic cardiomyopathy (DCM), male db/db and age-matched wild-type (WT) mice.

According to the experimental results from the analysis of broccoli sprout extract (BSE) by gavage every other day for 3 months, with four groups: vehicle (0.1 ml/10 g), BSE-low dose (estimated SFN availability at 0.5 mg/kg), BSE-high dose (estimated SFN availability at 1.0 mg/kg), and SFN (0.5 mg/kg),

* BSE, like SFN, showed a significant up-regulation of the Nrf2 transcriptional activity involved in the enhancing antioxidant enzymes observed by the increased Nrf2 nuclear accumulation and gene expression.

* The increased levels of antioxidant enzymes exerted a strong effect on the prevention of cardiac oxidative damage and inflammation.

* Additionally, the BSE at high dose provided a similar effect as did SFN.

Based on the results, researchers wrote, " BSE at high dose prevents DCM in a manner congruent with SFN treatment. Therefore, it suggests that BSE could potentially be used as a natural and safe treatment against DCM via Nrf2 activation".

Taken altogether, broccoli sprouts processed abundantly SFN may be considered supplements for the prevention of diabetic cardiomyopathy, pending to the confirmation of the larger sample size and multicenter human study.

Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Broccoli sprout extract prevents diabetic cardiomyopathy via Nrf2 activation in db/db T2DM mice by Xu Z1,2, Wang S1,2, Ji H1, Zhang Z1, Chen J2, Tan Y2,3, Wintergerst K3,4, Zheng Y1, Sun J1, Cai L. (PubMed)

Herbal Angelica Sinensis Induced Human Ovarian Cancer Cell Death in Vitro

By Kyle J. Norton

Cancer is the class of chronic disease caused by irregular cell growth in the tissue or specific organ in the body due to the alternation of cell DNA.

The ovaries are oval-shaped ovum-producing reproductive organ formed part of women reproductive system that connects to the fallopian tubes and attaches to the outer layer of the uterus via the ovarian ligament. Usually, the left and right ovary take a turn to release an egg every month.

Ovarian cancer is medical a condition characterized by abnormal cells growth of ovarian cells that start on the surface of the inner lining of the ovary. Over time, the oversize tumor can travel a distance away to infect the nearby organ and tissue via the fluid and blood circulation.

According to the statistics provided by the American Cancer Society, ovarian cancer is one of the dealy reproductive cancer in women. Every year, the disease causes more deaths than any other cancer of the female reproductive system.

The lifetime risk of getting ovarian cancer is a woman is about 1 in 78.comapred to the lifetime of dying from ovarian cancer risk of 1 in 108.

The 5-year relative survival of all stages of ovarian cancer is 47%. However, women with ovarian cancer diagnosed at the localized stage have a 5 years survival rate of over 92%.

The exact causes of ovarian cancer are not identified. However, epidemiological studies suggested that women who have endometriosis, genetic preposition such as BRCA1 and BRCA2 gene, acquired genetic mutation such as the TP53 tumor suppressor gene are susceptible to the risk of the development of the disease.

 The Canadian Cancer Society in the evaluation of the risk of ovarian cancer in women who are never being pregnant or giving birth wrote, "Women who have never been pregnant have a higher risk of developing ovarian cancer than women who have been pregnant".

And, "Researchers think that the lower risk maybe because the hormones that are present during pregnancy have a protective effect. It is possible that the higher risk in women who have never been pregnant is linked to the factors that may make it difficult for her to become pregnant". 

In other words, women who have at least one pregnancy are at a lower risk of ovarian cancer compared to women who do not.
 
On finding a natural ingredient for the prevention and treatment of cancers, Z-Ligustilide, the most potent bioactive component of Angelica Sinensis on ovarian cancer cells.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to the tested analysis,
* Z-Ligustilide resulted in apoptotic cell death by inducing oxidative stress on mitochondria.

* Furthermore. Z-Ligustilide enhanced the mitochondrial superoxide formation.

* NRF2, the antioxidant enzymes enhancer, and downstream antioxidant defense genes were elevated by tZ-Ligustilide in OVCAR-3 cells at the epigenetic level.

* Most importantly, NRF2 knockdown by siRNA resulted in increased cell death by Z-Ligustilide in ovarian cancer cells.

Based on the findings, researchers said, " Our result demonstrated the pro-survival role of NRF2 in Z-Ligustilide induced ovarian cancer cell death".

Taken altogether, angelica sinensis may be considered an antioxidant remedy for the prevention and treatment of human ovarian cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Apoptotic cell death induced by Z-Ligustilidein human ovarian cancer cells and role of NRF2 by Lang F1, Qu J2, Yin H3, Li L4, Zhi Y5, Liu Y6, Fang Z7, Hao E. (PubMed)

Cabbage Inhibits Human Cancer Cells in Vitro

By Kyle J. Norton

Cancers are a class of chronic diseases associated with irregular cell growth in the tissue and organs caused by the alternation of cell DNA.

At the advanced stage, malignant cells can travel a distance away from the original site to infect other healthy cells and tissues.

There are many types of cancer, depending on the location where cancer begins.

As of today, researchers do not know what are the exact cause of cancers. however many researchers believe, exposure to environmental toxins, genetic mutation, and an unhealthy diet and lifestyle are the most common risk factors associated with the onset of the diseases.

Healthy cells become cancerous if they grow uncontrollably and disorderly out of range of a normal healthy cell population which can only divide between 40 and 60 times.

According to the Hayflick limit theory, most cell survival is totally dependent on the telomeres on the ends of each chromosome.

Every time, healthy cells undergo division, the telomeres are shortened. Once the telomeres shorten to a critical length, the cells will die off. However, cancer cells can divide indefinitely.

According to the statistic provided by the UK Cancers research, in 2012, an estimated 14.1 million new cases of cancer occurred worldwide.

Sadly, more than 4 in ten cancers occurring worldwide are in countries at a low or medium level of the Human Development Index (HDI).

The Human Development Index (HDI) is a statistic composite index of life expectancy, education, and per capita income indicators, according to the definition.

In 2018, over 1,7 million new cases of cancer are diagnosed in the US, and approximately over 600,000 patients will die from the diseases.

The four most common types of cancer, occurring worldwide are lung, female breast, bowel and prostate cancer.

Early diagnosis as always is the best way to improve survival rate. Depending on types of cancer, most cancers have a 100% 5 years survival rate, if they are diagnosed at the stage of 0 and 1.

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.

On finding a natural wholefood for the prevention of malignant tumors, researchers examined the effects of pierisin, a protein purified from pupae of the cabbage butterfly, Pieris rapae on the human gastric cancer TMK-1 cell line and human umbilical vein endothelial cells (HUVECs).

According to the results of differentiation,

* Pierisin showed cytotoxic effects in all the human cells tested, with IC50 values ranging from 0.043 ng/ml to 150 ng/ml.

* Compared to other cancer cell lines, the cervical carcinoma cell line, HeLa, was the most sensitive to pierisin, showing a 1000-fold less IC50 value than that of HUVECs.

* Furthermore, pierisin clearly induced apoptotic cell death in most cancer cell lines and HUVECs through multiple different pathways including the proinflammatory, tumor-suppressive and immunomodulatory pathways.

Based on the results, researchers wrote, "Pierisin may thus be a promising new candidate for cancer therapy".

Taken altogether, cabbage may process anti-cancer activity, pending to the confirmation of the larger sample size and multicenter human study.




Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cytotoxic activity of pierisin, from the cabbage butterfly, Pieris rapae, in various human cancer cell lines by Kono T1, Watanabe M, Koyama K, Kishimoto T, Fukushima S, Sugimura T, Wakabayashi K. (PubMed)

Herbal Coltsfoot (Tussilago farfara), the Natural Treatment of Common Cold Symptoms

By Kyle J. Norton

The common cold is a condition of viral infection of the upper respiratory system that leads to symptoms of runny nose, nasal congestion, sneezing, sore throat, cough, headache, etc.

The condition is the most commonly occurring illnesses in the entire world, with more than 1 billion colds per year reported in the United States alone.

The common cold is a self-limiting illness caused by any 1 of more than 200 viruses.

Influenza, also known as the flu, is an infectious disease caused by an influenza virus.

 Influenza is no minor illness. If you are senior or have a serious heart and lung disease, you are at the greatest risk for coming down with a dangerous case of flu because your immune system might not be strong enough to fend off the infection.

There are 3 types of flu influenza: A, B, and C. the influenza virus A and B are considered seasonal flu that causes sniffling, aching, coughing, and running and stuffy nose and fever to over 20% of the general population.

Influenza virus types C tends to cause mild upper respiratory infections, similar to those of cold.

Healthy individuals who have influenza are usually recovered within one week.

However, people with immature and weakened immune system such as young children under age 5, adults older than age 65 residents of nursing homes and other long-term care facilities, chronic illnesses, such as asthma, heart disease, kidney disease, liver disease, and diabetes are not only associated with the risk of influenza but also increase the risk of influenza deadly complication.

Pregnant women and women up to two weeks postpartum due to change of the immune system and other organs have been found to make a woman more prone to influenza and influenza complications. 

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

According to Mylinh Nguyen, Jennifer Ramil, and Faith WydraWilkes University, Wilkes-Barre, PA

* A Chinese herbal cough syrup called Nin Jiom containing coltsfoot as its main ingredients (Meseyton, 2004). for the treatment of common cold symptoms

* Many chemicals found in coltsfoots such as bisabolene epoxide isolated from the flower buds of coltsfoot showed to inhibit nitric oxide synthesis in lipopolysaccharide-activated macrophages (Ryu, 1999) against the common cold virus.

* Additionally,  Oplopanone, an extract from T. farfara, has been found to process the activity of a respiratory stimulant.

Taken altogether, coltsfoot may be considered a remedy for the treatment of common cold and symptoms, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Determination of elements by atomic absorption spectrometry in medicinal plants employed to alleviate common cold symptoms by Küçükbay FZ, Kuyumcu E. (PubMed)
(2) Medical Attributes of Tussilago farfara - Coltsfoot by Mylinh Nguyen, Jennifer Ramil, and Faith Wydra Wilkes University, Wilkes-Barre, PA

Devil's Club Shows a Strong Anticancer Activities in Vitro and Vivo

By Kyle J. Norton

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Cancers are the second leading cause of death worldwide besides heart diseases.

The most common types of cancer in Canada include lung, colorectal, breast and prostate cancers. And these 4 cancers are account for half of all cancers diagnosed in Canada.

Believe or not, 1/4 of cancers death are due to lung cancer.

Depending on types of cancer, people with cancers may experience general and specific symptoms.
Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.

Most invasive cancers process angiogenetic ability by which they can divide and spread.

 Angiogenesis is the process that develops new blood vessels from pre-existing vessels by invasive tumors to provide energy(nutrition and fluids) for cancerous cells growth and proliferation. 

Devil's Club is a large shrub, genus Oplopanax, belonging to the family Aralioideae, native to the cool moist forests of western North America. 

The herb has been used in traditional and herbal medicine as Adaptogen, Antipyretic, Pain Reliever, Antitussive, Antibacterial agent and to treat Arthritis, Diabetes, Colds, Cough, Sore throat, Chest congestion, Stomach pain, Constipation, Gall stones, Influenza, Cancer, etc.

On finding a potential compound for the treatment of chronic diseases, scientists examined the anticancer effects of O. horridus (Devil's club).

* The different extracts from Oplopanax root, stem, berry, root bark, and their fractions were investigated in vitro for their potential antiproliferative effects on human HCT-116, HT-29, and SW-480 colorectal cancer cell lines [19–21, 47].

* Male and female transgenic C57BL/6J-Foxp3-RFP mice (C57BL/6- Foxp3tm1Flv/J) were employed for in vivo anti-AML. After one week following engraftment, the 70% ethanol extract of Oplopanax root was diluted into the drinking water at a final concentration of 20 g/mL. The survival of both male and female mice were significantly increased upon the inclusion of the extract in the drinking water [45].

*  The effects of the extracts and polyynes have also been evaluated using MCF-7 and MDA-MB-231 human breast cancer cell lines [19, 21, 47]. The IC50 of the total extract, 50, 70, and 100% ethanol fractions on MCF-7 cells were 248.4, 123.1, 44.0, and 31.5 g/mL, respectively [47].

* The antiproliferative effects of nonsmall cell lung cancer (NSCLC) cells were evaluated. The IC50 of the extract, 50, 70, and 100% ethanol fractions for antiproliferation on NSCLC cells, were 125.3, 271.1, 17.6, and 23.2g/mL, respectively [19].

* The extract significantly inhibited the proliferation of HP62 at low IC50. Apoptosis focused antibody array profile indicated upregulation of cytochrome C, claspin, cIAP-2, and HTRA2/Omi apoptosis-related markers, suggesting that the effect was via targeting the intrinsic mitochondrial apoptosis pathway [51]

Taken altogether, Devil's Club may be considered an anticancer remedy,, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure-Activity Relationship on Anticancer Effects by Wu K1, Wang CZ2, Yuan CS2, Huang WH. (PubMed)

Herbal Angelica Protects the Neurons Against Neuro-Inflammation in Vitro

By Kyle J. Norton



The central system is the complex of nerve tissues including the brain and spinal cord with functions to respond to the integrating sensory information.

Neuroinflammation is a process of the immune system that responds to harmful pathogens that induced oxidative stress to the brain.

Neuroinflammation is also the inflammation of nervous tissue associated with the immune response in the first phase of infection including infection, traumatic brain injury, toxic metabolites, or autoimmunity.

There many risk factors associated with the onset of neuroinflammation similar to other tissues inflammation, including infection, traumatic brain injury, toxic metabolites, or autoimmunity.

Inflammation is a natural response of the immune system in which the macrophages of the first defense stimulates the production of blood palette to cover the wound in case of injury and production of proinflammatory cytokines to the site of infection to fence off the foreign pathogens.

Inflammation also can be triggered by the immune mistakenly attacked the body tissues in cases of autoimmune disease.

Neuroinflammatory disease can be acute or chronic. Chronic neuroinflammation that leads to the activation of glial cells and the recruitment of inflammatory cytokines into the brain is found to associate with neurodegenerative diseases.

Most cases of the neuroinflammatory disease associated with the loss of neuronal structure and function.can be measured by the typical inflammatory markers, including CSF Aβ1-42, tau and p-tau181, and a panel of 37 neuroinflammatory markers in patients with Alzheimer's disease.

On finding a natural ingredient for the prevention and treatment of neurological disorders, scientists examined the effects of dangguishaoyao-san (DSS) (Angelica sinensis, Paeoniae radix, Rhizoma Ligusticum, Poria cocos, Rhizoma Atractylodis Macrocephalae, and Rhizoma Alismatis) on lipopolysaccharide (LPS)-stimulated BV-2 microglial cells.
Angelica or Danggui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to the results of BV-2 cells pretreated with 0.58-1.16 mg/mL of DSS for 2 h and then treated with 1 μg/mL LPS for 24 h,
* DSS treatment at concentrations of 0.58-1.16 mg/mL did not induce significant cytotoxicity.

* DSS attenuated the release of pro-inflammatory factors, such as interleukin-1β (IL-1β), iNOS and tumor necrosis factor-α (TNF-α) in LPS-induced BV-2 cells.

* DSS attenuated the mRNA expression of pro-inflammatory cytokines, TLR2, and TLR4 by decreasing TLR4 and TLR protein levels and decreased levels of phosphorylation of IκB which regulates the cellular response to inflammation in LPS-induced BV-2 cells.

* DSS also down-regulated the nuclear translocation of p65 in the initiation of cancer cell proliferation and survival.

Based on the results, researchers suggest, " DSS has a protective effect on neuroinflammation in LPS-induced BV-2 microglial cells through the TLRs/NF-κB signaling pathway".

Taken altogether, Dandelion may be considered an antioxidant remedy for the treatment of neuroinflammation, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dangguishaoyao-San attenuates LPS-induced neuroinflammation via the TLRs/NF-κB signaling pathway by Ding RR1, Chen W1, Guo CY1, Liao WT1, Yang X2, Liao FE3, Lin JM4, Mei HF5, Zeng Y. (PubMed)

Cruciferous Vegetables Reduces the Ris of Cardiovascular Diseases (CVD)

By Kyle J. Norton

Chronic diseases are medical conditions that last more than 3 months depending on the type of diseases.

In other words, chronic diseases generally cannot be prevented or cured by medication, nor do they just disappear.

According to the statistics, chronic diseases affect millions of people worldwide, leading to the death of 35 million people in 2005, including many young people and those in middle age.
Cardiovascular disease (CVD) is a group of conditions associated with the heart and blood vessels.

Cardiovascular diseases are chronic diseases that refer to heart diseases, affecting millions of people in the world. According to statistics, over 17.7 million people died from CVDs in 2015.

In other words, anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease.

The causes of cardiovascular diseases are associated with the accumulation of plaques in the arteries, impeding the blood flow which carries the nutrients and oxygen to the heart, which causes damage to the heart tissue and reduced function of the arteries.

Hyperlipidemia and hypertension are the risk factors of the diseases.

According to the statistic cardiovascular disease is the leading cause of death in women in the US with 90% of women having one risk factor.

Believe it or not, women are 4 times more likely to die from heart disease than breast cancer and 2/3 of women are not aware of heart disease is such a risk for them, according to the Jean Hailes for Women Health in the article cardiovascular health.

According to statistics, heart disease is the second leading cause of death, claiming more than 48,000 lives every year.in Canada.

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

On finding a potential remedy for the prevention and treatment of cardiovascular diseases,  researchers the effect of sulforaphane against cardiovascular disease via Nrf2 activation.

According to the results of the experiment,
* Sulforaphane (SFN) is an ITC exerted anticancer activity by both in vivo and epidemiological studies.

* SFN demonstrated strong antioxidant and anti-inflammatory properties in CVD.

* SFN activated NF-E2-related factor 2 (Nrf2) that serves as a defense mechanism against oxidative stress and electrophilic toxicants by inducing more than a hundred cytoprotective proteins, including antioxidants and phase II detoxifying enzymes.

Based on the results, researchers said, "the evidence from clinical studies and animal experiments relating to the potential mechanisms by which SFN modulates Nrf2 activation and protects against CVD".

Taken altogether, cruciferous vegetables may be considered functional remedies for the prevention of CVD, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation by Bai Y1, Wang X2, Zhao S3, Ma C4, Cui J5, Zheng Y. (PubMed)