Herbal Coltsfoot(Tussilago farfara) Protects the Neurons Against Oxidative Injury

By Kyle J. Norton

Amyloid beta (Aβ or Abeta) is the main component of the amyloid plaques that cause the gradual death of neurons, leading to the onset of Alzheimer's disease.

Alzheimer's disease is a common form of dementia or neurodegenerative disease found in the elderly.

Alzheimer's disease is a type of dementia correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer.

According to the statistics, the disease is most prevalent in the elderly. Approximately 5.7 million Americans of all ages are living with Alzheimer's. 15.9 million family caregivers provide an estimated 18.2 billion hours and $230 billion to people with dementia worldwide.

 Alzheimer's disease is caused by a combination of genetic, lifestyle and environmental factors that affect the neurons of the brain over time. However, less than 10% of patients with AD are associated with a genetic preposition. Patients with such mutated genes on chromosomes 21, 14, and 1are virtually guaranteed to develop the disease.

More precisely, Alzheimer's disease is caused by the gradual loss of neuron functioning that usually starts with the early symptom of the difficulty of remembering recent events and worsens over time.

Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal.

Dementia is a group of neurodegenerative diseases caused by a decline in mental ability in the older population that is severe enough to interfere with daily life, such as memory loss.

Compared to dementia, neurological disorders are a class of brain disease associated with reduced function of the brain, depending on the region of the neurons that were affected.

Dr. Rudolph E. Tanzi said, "The inheritance of AD exhibits a dichotomous pattern. On one hand, rare mutations in APP, PSEN1, and PSEN2 virtually guarantee early-onset (<60 years) familial AD, which represents ∼5% of AD. On the other hand, common gene polymorphisms, such as the ε4 and ε2 variants of the APOE gene, can influence susceptibility for ∼50% of the common late-onset AD".

And, " These four genes account for 30%–50% of the inheritability of AD".

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

On finding a potential compound for the treatment of hypercholesterolemia, researchers examined the anti-inflammatory effect against oxidative injury of Tussilagone (TSL), isolated from the flower of buds of Tussilago farfara (Compositae) by examing the quinone reductase cellular detoxification in Hepa1c1c7 cells.

According to the results of the analysis, herbal coltsfoot decreased the activity tert-butyl hydroperoxide(t-BHP), an organic peroxide widely used in a variety of oxidation processes, -induced ROS production and cell death, through its potent antioxidant.

Furthermore, NRF2, that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation showed to upregulate the detoxifying enzymes NAD(P)H quinone dehydrogenase 1(NQO1) and heme oxygenase-1(HO-1) against oxidative stress.

Moreover, (ERK1/2), the mitogen-activated protein kinase superfamily that can mediate cell proliferation and apoptosis was also mediated by the expression of NRF2.

In other words, coltsfoot showed a strong activity to attenuate t-BHP-induced ROS and Nrf2 pathway activation to inhibit the overexpression of reactive oxidative species induced free radical domino's activities against HepG2 cells from oxidative stress and associated damage.

Taken altogether, coltsfoot may be considered a remedy for the treatment of disease associated with oxidative injury, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tussilagonone-induced Nrf2 pathway activation protects HepG2 cells from oxidative injury by Lee KM1, Kwon TY1, Kang U2, Seo EK2, Yun JH3, Nho CW3, Kim YS. (PubMed)

Oleanolic Acid, The Antioxidant That Inhibits the Onset of Diabetes in Vivo

By Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

The pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen. By secreting pancreatic juice to the small intestine, the pancreas helps to break down carbohydrates, proteins, and lipids. 

Traditional Chinese medicine views the pancreas as a vital organ that is responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our bodies.

According to statistics, diabetes is one of the most common diseases in the US. Approximately 10% or 29.1 million people in the United States have diabetes, accompanied by 8.1 million that are undiagnosed and unaware of their condition.

About 1.4 million new cases of diabetes are diagnosed in the United States every year. More than one in every 10 adults who are 20 years or older has diabetes.

Hyperglycemia, a medical condition of abnormally high blood glucose, is a major concern, in people with both type 1 and type 2 diabetes.

Most cases of hyperglycemia occurred in patients who do not manage their diabetes properly.

Hyperglycemia, a hallmark of diabetes has been found to induce diabetics complications, including neuropathy, nephropathy, and retinopathy). ...

Oleanolic acid is a phytochemical in the subclass of triterpenoid, belongings to the group of Terpenes found abundantly in honey mesquite, garlic, java apple, clove, etc.

On finding a potential plant that processes anti-chronic disease activity researchers examined the hematological effects of oleanolic acid (OA) in streptozotocin- (STZ-) induced diabetic rats.

The study included animals that were separated into five groups; the nondiabetic group (ND), the diabetic control group (DC), and the treatment groups of insulin (170 μg/kg, s.c), metformin (500 mg/kg, p.o), and OA (80 mg/kg, p.o). OA was administered orally twice a day.

According to the results of the analysis,
* Untreated diabetic rats exhibited hyperglycemia, elevated glycated hemoglobin (HbA1c), oxidative stress, and a reduced erythropoietin (EPO) concentration when compared to ND rats.

* The administration of OA attenuated hyperglycemia, HbA1c, and EPO concentrations compared to DC rats.

* Furthermore, OA also decreased the blood glucose concentration, HbA1c, and improved EPO concentrations associated with a notable increase in red blood cell (RBC) count and other RBC indices.

* Moreover, OA increased the antioxidant status of the RBCs with a concomitant decrease in oxidative stress.

Collectively, researchers said, "These findings suggest that OA improves diabetes-induced hematological changes caused by hyperglycemia and attenuates the progression of cardiovascular complications in DM individuals".

Taken altogether, oleanolic acid may be considered a remedy for the prevention and treatment of diabetes, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Haematological Effects of Oleanolic Acid in Streptozotocin-Induced Diabetic Rats: Effects on Selected Markers by Baloyi CM1, Khathi A1, Sibiya NH2, Ngubane PS. (PubMed)

Angelica Sinensis, the Natural Anticancer Herbal Remedy

By Kyle J. Norton

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

The American Cancer Society wrote, "Cancer may also cause symptoms like fever, extreme tiredness (fatigue), or weight loss. Because cancer cells use up much of the body’s energy supply, or they may release substances that change the way the body makes energy from food. Cancer can also cause the immune system to react in ways that produce these signs and symptoms" and " Sometimes, cancer cells release substances into the bloodstream that cause symptoms that are not usually linked to cancer".

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.

The prevalent factors associated with the risk of cancer are age, excessive alcohol drinking, exposure to cancer causing-substances, diseases associated with chronic inflammation, unhealthy diet, hormones therapy, use of immunosuppression.

Cancers are the second leading cause of death worldwide besides heart diseases. Believe or not, 1/4 of cancers death are due to lung cancer.

On finding a natural ingredient for the prevention and treatment of chronic diseases, scientists examined Radix Angelica Sinensis (Danggui in Chinese) is widely used in traditional Chinese medicine (TCM). N-butylidenephthalide (BP), a bioactive compound in Dangui, is a potential antitumor agent for various cancer types.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to the experimental results,

* Danggui users were found to have an increased survival rate when compared with Danggui nonusers (log-rank test p = 0.002).

* The use of Danggui highly associated with decreased mortality (the adjusted hazard ratio (HR) of Danggui user was 0.72 [95 % CI, 0.57-0.92] (p = 0.009).

* The in vitro results showed that BP inhibited gastric cancer cell proliferation, and triggered cellular apoptosis depending on the activation of the mitochondrial apoptotic pathway.
* According to the RNA-seq analysis, BP induced an increase of REDD1 expression that inhibits mTOR signaling, thus inhibiting gastric cancer growth.

* BP suppressed the growth of AGS xenografts tumor in vivo.

Based on the results, researchers suggest, "Danggui can prolong the survival rate of gastric cancer patients in Taiwan. BP caused gastric cancer cell death through the activation of mitochondria-intrinsic pathway and induced the REDD1 expression leading to mTOR signal pathway inhibition in gastric cancer cells".

Taken altogether, Dandelion may be considered anti-cancer activity, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-Cancer Effects of Radix Angelica Sinensis (Danggui) and N-Butylidenephthalide on Gastric Cancer: Implications for REDD1 Activation and mTOR Inhibition by Liao KF1,2, Chiu TL3,4, Huang SY5, Hsieh TF3,6, Chang SF7, Ruan JW8, Chen SP9, Pang CY10,11, Chiu SC. (PubMed)

Broccoli Exerts Anti-Metastatic Activities Via Innate Immune Cell Activation

By Kyle J. Norton

Cancer is a class of diseases associated with irregular cell growth on the tissue of the specific organ.

Most cases of invasive cancer can spread to other organs in the body via lymph or blood.

According to the statistics provided by the Cancer Institue, between n 2011–2015, the number of new cases of cancer is 439.2 per 100,000 men and women per year (based on 2011–2015 cases).

The number of cancer deaths (cancer mortality) is 163.5 per 100,000 men and women per year.

In cancer cells, due to the alternation of DNA, can grow indefinitely.

Cancer cell metastasis is the process that cancer cells break away from the primary site and travel through the blood or fluid circulation and form new tumors (metastatic tumors) in other parts of the body, similar to those of primary cancer.

The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.

Through the expression of the lines of defense, depending on the stage of pathogenic invasion, the innate immune response protects the body via a different set of interactions.

In the acute phase of infection, the macrophages in the immune system stimulate the production of inflammatory cytokines to the site of the damage. The inflammatory cytokines not only play a critical role in stopping the stimuli from entering into the body but also speeds up the wound healing through growth factors.

The innate immune system also can destroy the damaged cells such as cancer cells through the T cell activation of B cells which in turn stimulates the production of a protein associated with the production of antibody p53.

Some researchers suggested immune system also can kill cancer cells by reacting to activating cytokines (IFN-α/β, IL-12, IL-15, IL-18, IL-21) produced by tumor cells or by other immune cells stimulated by tumor cells.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

On finding natural food for the prevention and treatment of cancer proliferation, researchers examined the anti-metastatic activities of polysaccharides in broccoli, including BCE-I mainly consisted of galactose and arabinose, whereas BCE-II mainly consisted of galacturonic acid and rhamnose, and BCE-III mainly consisted of rhamnose and galactose.

According to the results of the analysis, 

* BCE-I showed the greatest enhancement the pro-inflammatory proteins such as tumor necrosis factor-α, interleukin (IL)-12, and IL-6 secretion by stimulating murine peritoneal macrophages in the immune response.

* Furthermore, intravenous (i.v.) administration of BCE-I enhanced the lethal activity on YAC-1 tumor cells significantly and dose-dependently in an ex vivo by exhibiting the natural killer (NK) cells.

* On lung metastasis of Colon26-M3.1 carcinoma cells, prophylactic i.v. and oral administration of BCE-I significantly and dose-dependently inhibited lung metastatic activity.

In other words, the inhibitory activity of BCE-1 on lung metastasis are depending on the NK cell function in GM1 activity.

Based on the results, researchers wrote, " BCE-I has potent antitumor metastatic activity, and that its anti-metastatic activity has relevance to the stimulation of NK and other immune cells".

Taken altogether, broccoli sprouts processed abundantly SFN may be considered supplements for the inhibiting the cancer cell metastasis, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Rhamnogalacturonan-I-Type Polysaccharide Purified from Broccoli Exerts Anti-Metastatic Activities Via Innate Immune Cell Activation by Kwak BS1, Hwang D2,3, Lee SJ1, Choi HJ4, Park HY5, Shin KS. (PubMed)

Herbal Eyebright ( Euphrasia) Protects the Human Corneal Cell Integrity

By Kyle J. Norton

Human Corneal Epithelial Cells (HCEpC) isolated from the epithelium of the Human Cornea have been used in a wide range of basic ocular studies involving problems associated with the cornea.

The corneal epithelium is the barrier function that plays a critical role to defend against many types of injury, trauma, or infection.
The cornea accounting for approximately two-thirds of the eye's total optical power covers,
* The iris

the iris (plural: irides or irises) is a thin, circular structure in the eye that controls the diameter and size of the pupil to allow the amount of light reaching the retina.
* The pupil
The pupil is a black hole located in the center of the iris that allows light to reach the retina
* The anterior chamber
The anterior chamber (AC) is space in the eye that is behind the cornea and in front of the iris.

In other words, the cornea, with the anterior chamber and lens, refracts light, with the cornea

Corneal disease happened mostly in the aging population, is a medical condition that can cause clouding, distortion, scarring and eventually blindness.

Other common causes of corneal diseases are infection, cataract, genetic proposition, use of contact lense, eye injury, and diseases, including retinitis pigmentosa, retinopathy of prematurity, and vernal keratoconjunctivitis, Ehlers-Danlos syndrome, and Down syndrome.

On finding a natural ingredient for the prevention and treatment of eye inflammation, scientists examined the protective effects of eye drop containing Matricaria chamomilla and Euphrasia officinalis extracts in UVB-induced oxidative stress and inflammation of human corneal cells.

Eyebright is one of the species of flowering plants, genus Euphrasia, belonging to the family Orobanchaceae, native to Europe. 

The plant has been used in traditional and herbal medicine to treat eye infection and to relieve inflammation caused by colds, coughs, sinus infections, sore throats, and hay fever.

According to the tested analysis of HCEC-12 cells exposed to UVB radiation and treated with the eye drops at various concentrations,
* The administration of eye drops protect corneal epithelial cells from UVB-induced cell death and ameliorated the wound healing.

* The eye drops exhibited a strong antioxidant activity in the inhibition of ROS expression and protein and lipid oxidative damage.

* Furthermore, the eye drops also exerted anti-inflammatory activities by decreasing the proteins in activating the pro-inflammatory cytokines such as COX-2, IL-1β, iNOS expression,

* Moreover, the eye drops counteracted UVB expression by inducing antioxidants expression of glutathione synthetase (GSS) and superoxide dismutase 2(SOD-2) expression and restoring the HO-1 levels to control levels.

Based on the results, researchers suggest, "These findings suggest that an eye drop containing Matricaria chamomilla and Euphrasia officinalis extracts exerts positive effects against UVB induced oxidative stress and inflammation and may be useful in protecting corneal epithelial cells from UVB exposure".

Taken altogether, Dandelion may be considered a remedy for the protection of human corneal cells, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Pharmacological activities of an eye drop containing Matricaria chamomilla and Euphrasia officinalis extracts in UVB-induced oxidative stress and inflammation of human corneal cells by Bigagli E1, Cinci L1, D'Ambrosio M1, Luceri C2. (PubMed)

Tocopherols Deficiency In the Risk of Age-Related Macular Degeneration

By Kyle J. Norton

Neurodegenerative diseases are a class of conditions associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.

Most common disease associated with neurodegenerative diseases is dementia, a cluster of conditions included Parkinson’s, Alzheimer’s, and Huntington’s disease, leading to a negative influence the body's functioning, including balance, movement, talking, breathing, and heart function.

There is no single cause of the progressive death of brain neurons. Epidemiologically, genetic preposition, medical conditions, such as alcoholism, brain cancer or a stroke in the brain are some of the most common prevalent factors found in patients with neurological diseases.

Age-related macular degeneration is a medical condition that causes irreversible blurring of the central vision in people over age 60.

The elderly at the early stage of age-related macular degeneration is asymptomatic. However, some patients may experience symptoms of slightly blurred central vision. Most cases of the early stage of AMD were diagnosed during routine eye health examinations.

Over time, age-related macular degeneration may affect the vision including the reading as the blurred area increase in size.

The advanced age-related macular degeneration has been found to induce irreversible blindness and visual impairment, according to the epidemiological studies.

According to statistics, approximately 11 million people in the US have some form of age-related macular degeneration. The risk of getting advanced age-related macular degeneration increases from 2% for those ages 50-59 to nearly 30% for those over the age of 75.

Age-related macular degeneration can be classified into 2 types
* The common AMD is the dry form caused by the gradual degeneration of the central retinal tissues, affecting 90% of patient s with AMD. Some patients with the dry form of AMD have been found to develop into the wet form over time.

* The wet form of AMD is caused by the breaking of capillary under the macula, accounting only 10% of AMD.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of degenerative diseases, researchers compared the effects of dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene on age-related macular degeneration.

According to the results of a brief-type self-administered questionnaire of the case-control study that reports the association between nutrient intake and neovascular age-related macular degeneration (AMD) from of 161 neovascular AMD cases from two university hospitals and 369 population-based control subjects in Japan, 

* Low intakes of n-3 fatty acid, α-tocopherol, zinc, vitamin D, vitamin C, and β-carotene were associated with neovascular AMD.

In other words, low levels of serum of tocopherols were associated with increased risk of AMD.

* There was no association with retinol or cryptoxanthin intake and neovascular AMD.

These results were adjusted based on smoking history, age, sex, chronic disease history, supplement use, and alcohol consumption

Taken altogether, tocopherols may be considered an adjunct therapy in the treatment of AMD, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan by Aoki A1,2, Inoue M3, Nguyen E4, Obata R1, Kadonosono K3, Shinkai S2, Hashimoto H5, Sasaki S4, Yanagi Y. (PubMed)

Healthy Food Broccoli's Sulforaphane (SFN) Blocks the Onset of Diabetic Cardiomyopathy in Diabetes

By Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Diabetic complications are any diseases associated with hyperglycemia if the blood glucose is not managed properly. Patients with diabetes may induce a number of complications including cardiovascular disease, neuropathy, nephropathy, retinopathy, and foot ulcer.

Cardiomyopathy is a disease associated with heart muscle, leading to reduce functions of the heart to pump blood to the rest of the body.

Diabetic cardiomyopathy is a complication found in patients with diabetes associated with reducing the heart function in circulating blood through the body, leading to heart failure and increased accumulation of fluid in the lungs.

Diabetic cardiomyopathy is classified into different types, depending on the damage that has been affected, including
* Microangiopathy is a disorder that affects small blood vessels, leading to impaired myocardial blood flow reserve.

* Autonomic neuropathy is a disorder that affects the nerves that manage everyday body functions, leading to abnormal blood pressure, heart rate.

* Endothelial dysfunction is a disorder associated with the damage of vascular endothelium. The condition is considered an early event of cardiovascular disease.

The most common causes of diabetic cardiomyopathy are myocardial dysfunction in the absence of overt clinical coronary artery disease, valvular disease, and other conventional cardiovascular risk factors, such as hypertension and dyslipidemia.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

With an aim to find a natural food for the prevention and treatment of diabetic complications, researchers examined the effect of sulforaphane (SFN) on T2DM-induced cardiac lipid accumulation and subsequent cardiomyopathy.

The study included male C57BL/6J mice fed a high-fat diet for 3months to induce insulin resistance, followed by treatment with 100mg/kg body-weight streptozotocin to induce hyperglycemia as the T2DM mouse model compared to age-matched mice fed a normal diet as control.

According to the tested analysis,
* SFN treatment significantly attenuated cardiac remodeling and dysfunction induced by T2DM.

* SFN treatment also significantly inhibited cardiac lipid accumulation, measured by Oil Red O staining, and improved cardiac inflammation oxidative stress and fibrosis, shown by down-regulating diabetes-induced PAI-1, TNF-α, CTGF, TGF-β, 3-NT, and 4-HNE expression involved in oxidation.

* SFN upregulated the expression of the gene associated with the promotion of antioxidant enzyme and decreased the expression in enhancing the initiation of oxidative stress.

* SFN also reversed diabetes-induced inhibition of LKB1/AMPK and its downstream targets associated with the regulation of lipid, cholesterol and glucose metabolism.

Based on the results, researchers wrote, " SFN treatment to T2DM mice may attenuate the cardiac oxidative stress-induced inhibition of LKB1/AMPK signaling pathway, thereby preventing T2DM-induced lipotoxicity and cardiomyopathy".

Taken altogether, broccoli processed abundantly SFN may be considered supplements for the prevention of diabetic cardiomyopathy, pending to the confirmation of the larger sample size and multicenter human study.



Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway by Zhang Z1, Wang S1, Zhou S1, Yan X2, Wang Y1, Chen J3, Mellen N3, Kong M4, Gu J5, Tan Y2, Zheng Y6, Cai L. (PubMed)