Saturday, 7 March 2020

How to Make Homemade and Natural Hand Sanitizers against #Coronavirus, According to Doctors

By Kyle J. Norton

According to Dr. Nina A. Gold and Dr. Usha Avva at the Hackensack University Medical Center
Joseph M. Sanzari Children's Hospital

Data suggests that more than 1.4 million patients in developed and developing countries worldwide are affected at any time. There is ample evidence that hand antisepsis reduces the transmission of healthcare-associated pathogens and the incidence of HCAI... and More

The link below will give you all the information that you need to make effective natural Hand Sanitizers


Herbal Dandelion(Taraxacum officinale) Inhibits the Diseases Associated with Dengue Virus Serotype 2

By Kyle J. Norton

Infection is a condition that caused the invasion of stimuli and micro pathogens, including viral infection.

Similar to bacterial infection, both infections shared common characteristics by spreading through coughing and sneezing by and contact with infected people, especially through kissing and sex.

However, unlike bacteria, a virus replicates only inside the living cells of an organism. Viruses can infect all types of life forms, including humans and microorganisms, such as bacteria and archaea.

Anti-viral effects are the process that certain substances are used to cause the destruction of a virus.

In the acute phase of viral infection, depending on the types of viruses, the viruses after entering the body start to attack the specific host cells. The cold and flu virus will attack the cells in the respiratory system and the human immunodeficiency virus (HIV), which causes AIDS, will attack the white blood cells of the immune system,

The viral infection has been known to carry over some different stage, after successfully attaching to the host cell, the virus to release its mRNA into the host cell, leading to the recruit of the host cell's enzymes to accelerate the viral multiplying, then breaking free from the host cell to start the cycle all over again.

The white blood cells in the systematic immune response in the acute phase of infection stimulate the production of the proinflammatory cytokines to the site of infection with an aim to protect our body by killing off the invaders.

The battle between the immune white blood cell and viral invaders in most cases an in the flavor of the side of the immune system, the invaders are killed and the infection is healed.

However, if the immune system can not kill off the invaders with 3 - 8 weeks, it then will adapt to the change, leading to chronic inflammatory and infectious diseases.

Dengue virus (DENV) belongs to the Flavivirus genus and is transmitted by Aedes aegypti and Ae. Albopictus mosquitoes, found in tropical and subtropical regions of the world. In severe cases, dengue virus serotype 2 has been found to induce symptoms of severe plasma leakage, severe hemorrhage and/or severe organ impairment.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of infectious diseases, scientists examined the cytotoxic concentration and the inhibitory effect of extracts or fractions from Urtica dioica, Taraxacum officinale, Calea integrifolia and Caesalpinia pulcherrima on the dengue virus serotype 2 (DENV2 replication on the BHK-21 cell line.
According to the tested differentiation,
* The methanolic extracts at 60 °C of T. officinale and U. dioica showed the higher inhibitory effects on DENV2 replication.

* The chemical analysis suggested that the higher activity fraction is found for U. dioica and T. officinale, at the IC50 values of 165.7 ± 3.85 and 126.1 ± 2.80 μg/ml, respectively.

The compounds which  exhibited the efficacy of T. officinale were luteolin and caffeoylquinic acid derivatives and quercetin diclycosides compared to the compounds in the active fraction chlorogenic acid, quercetin derivatives and flavonol glycosides (quercetin and kaempferol) in the U. dioica.

Based on the results, researchers suggest, "Two fractions from U. dioica and T. officinale methanolic extracts with anti-dengue activity were found. The compounds present in both fractions were identified, several recognized molecules have demonstrated activity against other viral species".


Taken altogether, dandelion may be considered an antioxidant remedy for the treatment of dengue virus serotype 2, pending to the confirmation of the larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Taraxacum officinale and Urtica dioica extracts inhibit dengue virus serotype 2 replication in vitro by María R. Flores-Ocelotl,1,2,3 Nora H. Rosas-Murrieta,4 Diego A. Moreno,5 Verónica Vallejo-Ruiz,1 Julio Reyes-Leyva,1 Fabiola Domínguez,2 and Gerardo Santos-López. (PMC)

Herbal Coltsfoot(Tussilago farfara) Processes Antitussive Activity Against Coughing

By Kyle J. Norton

Coughing is a natural reflex that clears the throat of mucus or foreign pathogens. Frequent coughing may be a condition of infection caused by inflammation of the airway.

An acute cough is a condition that lasts for less than three weeks. Chronic coughing that lasts more than 3 weeks may be a condition of respiratory diseases, including asthma, allergies, gastroesophageal reflux disease (GERD), or bronchitis.

Phlegm produced in the lungs and lower respiratory tract is a type of mucus found mostly in acutely sick or longstanding health conditions patients.

Chronic mucus collected in the lungs has been associated with patients with tuberculosis (TB), pneumonia, a fungal infection, whooping cough early in life and measles.

Seriously, chronic mucus collected in the lungs increases a significant risk of further infections and more damage.

Antitussive is a type of substance used to prevent or relieve a cough.

The most common type of antitussive drugs used for the treatment of cough is dextromethorphan

Another expectorant available in OTC products is guaifenesin.

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

On finding a potential compound for the treatment of chronic cough, researchers examined the anti-antitussive effect of Tussilagone (TSL) chemical constituents, chlorogenic acid (1), 3,5-dicaffeoylquinic acid (2), 3,4-dicaffeoylquinic acid (3), and 4,5-dicaffeoylquinic acid (4).isolated from the flower of buds of Tussilago farfara (Compositae).

The study included selected mice orally treated with these compounds and their mixture (in a ratio of 5:28:41:26 as in EtE) at doses of 10 and 20 mg/kg once daily for 3 days.

According to the tested analysis, chemical compounds 4,5-dicaffeoylquinic acid (4) exerted a significant anti-inflammatory activity by 49.7%.observed by the leukocyte count in the bronchoalveolar lavage fluid associated with acute airway inflammation compared to the other compounds.

Moreover, 4,5-dicaffeoylquinic acid (4) also inhibited 58.0% in cough frequency.

Based on the findings, researchers said, "The caffeoylquinic acids and their mixture, exhibiting significant antitussive,...and anti-inflammatory effects, could be considered as the main effective ingredients of FTF, and they may act in a collective and synergistic way.".

Taken altogether, coltsfoot may be considered an antitussive remedy, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antitussive, expectorant, and anti-inflammatory activities of four caffeoylquinic acids isolated from Tussilago farfara by Wu QZ1, Zhao DX1, Xiang J1, Zhang M1, Zhang CF1, Xu XH. (PubMed)

Friday, 6 March 2020

Angelica Sinensis Protects the liver Against Toxicity

By Kyle J. Norton

The liver is the largest internal organ in the human body and the only organ which can regenerate itself. The liver is the first line of the bodily toxin defense by filtering the blood that comes from the digestive tract, before passing it to the rest of the body.

The liver also produces cholesterol that plays a critical role in building strong cell membranes, producing steroid hormones and vitamin D and aiding the digestive function in food absorption and detoxifying chemicals and metabolizing drugs.

The hepatoprotective or liver protective effect is an action that maintains the liver's healthy functioning against any harmful toxins, including detoxification which is a natural process of our body to maintain the proper function and protect our organs and tissues against toxicity by eliminating toxins accumulated.

When they fail, the toxic accumulations cause a disruption of hormone production, damage the body's detoxification organs and weaken the immune system, leading to hormone imbalance and much chronic illness consequently.

Symptoms of liver diseases include jaundice, abdominal pain, and swelling, swelling in the legs and ankles, itchy skin, dark urine, and pale stool color, and a tendency to bruise easily.

There are no exact causes of liver disease. viruses, toxins, genetics, alcohol, and unknown causes are some prevalent factors found in patients with chronic liver disease, including cancer.

In the US, most cases of liver disease are a result of hepatitis viral infection and autoimmune diseases. Infectious viral hepatitis can produce toxins to protect them against the antioxidant enzymes produced by the host body and prevent the attack of the systematic immune response.

Furthermore, in recent years, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.

On finding a natural ingredient for the prevention and treatment of liver diseases, scientists examined the hepatoprotective effects of polysaccharides-enriched fraction from the root of Angelica sinensis in rodents.

Angelica or Dang Gui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to tested analysis,
* Intra-gastric administration of Angelica sinensis polysaccharides-enriched fraction (AP) at the doses of 50 or 75 mg/kg dose-dependently prevented liver toxicity induced by acetaminophen in mice but did not affect the serum acetaminophen concentration.
* AP inhibited the liver stress markers alanine transferase (ALT), malondialdehyde (MDA) and hepatic nitric oxide synthase (NOS) activities and glutathione level in the liver.

* In the carbon tetrachloride (CCl4) induced liver damage animals, AP showed weak protective activity.

* However, a higher dose of AP inhibited the MDA level without affecting the serum ALT level, the hepatic glutathione level instead while the NOS activity in CCl4 induced liver damage rats.

Based on the results, researchers suggest, "These findings suggest that the pathogenic mechanisms of both acetaminophen and CCl4 are different. AP is more effective in the protection against liver damage induced by acetaminophen, which is associated with the glutathione depletion and nitric oxide synthase activation in the liver".

Taken altogether, Dandelion may be considered a remedy for the protection against liver damage, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective effect of polysaccharides-enriched fraction from Angelica sinensis on hepatic injury by Ye YN1, Liu ES, Li Y, So HL, Cho CC, Sheng HP, Lee SS, Cho CH. (PubMed)
(2) Protection of Angelica sinensis (Oliv) Diels against hepatotoxicity induced by Dioscorea bulbifera L. and its mechanism by Niu C1, Wang J, Ji L, Wang Z. (PubMed)

Omega 3 Fatty Acid Inhibits the Onset of Acute Steatohepatitis in Vivos

By Kyle J. Norton

Steatohepatitis is a fatty liver disease caused by inflammation of the liver tissue accompanied by fat accumulation.

A most common form of steatohepatitis is non-alcoholic steatohepatitis (NASH), an advanced form of non-alcoholic fatty liver disease (NAFLD) that is not caused by excessive alcohol drinking.

Most cases of NASH if untreated can lead to liver scars or building up of scar over time, a condition of liver cirrhosis and one of the most common causes of liver cancer.

Most people with non-inflammatory-alcoholic fatty liver disease are asymptomatic, however, the inflammation caused by non-alcoholic steatohepatitis may induce liver damage, leading to a reduced function of the liver that orchestrates the onset of liver symptoms.

The most common symptoms are abdominal swelling, enlarged blood vessels just beneath the skin's surface, enlarged spleen, red palms, and jaundice.

People with steatohepatitis have been associated with the increased risk of liver failure and liver cancer, due to excessive formation of liver scar tissues, epidemiologically.

According to the statistics, fatty liver affects approximately 25% of the general population worldwide. Non-alcoholic steatohepatitis (NASH), is very common in overweight persons.

Researchers do not know the exact cause of steatohepatitis. However, they do know certain medical conditions such as diabetes, being overweight or obese and people with metabolic syndrome, including high blood cholesterol are some most prevalent risks of the disease.

Some researchers suggested that people who are viral hepatitis carriers are also at risk of steatohepatitis.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of liver diseases, researchers examined the ω-3-acid ethyl ester prescription Lovaza effects on acute steatohepatitis.

According to the results of the study,
* In vivo, administration of CMPF to mice before or after high-fat diet feeding at exposures equivalent to those observed in humans increased whole-body lipid metabolism, improved insulin sensitivity, increased beta-oxidation, reduced lipogenic gene expression, and ameliorated steatosis.

* CMPF acutely inhibits Acetyl-CoA Carboxylase (Acc) activity in the monitoring of liver enzymatic activity and induces long-term loss of SREBP1c and ACC1/2 expression in lipid metabolism.

* CMPF upregulated the expression of FGF21, which is required for long-term steatosis protection.

Moreover, researchers said, "MPF treatment in mice parallels the effects of human Lovaza™ supplementation, revealing that CMPF may contribute to the improved metabolic effects observed with ω-3 fatty acid prescriptions".

Taken altogether, Omega-3 fatty acids may be considered a functional food for the prevention and treatment of acute steatohepatitis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) CMPF, a Metabolite Formed Upon Prescription Omega-3-Acid Ethyl Ester Supplementation, Prevents and Reverses Steatosis by Prentice KJ1, Wendell SG2, Liu Y1, Eversley JA1, Salvatore SR2, Mohan H1, Brandt SL1, Adams AC3, Serena Wang X1, Wei D1, FitzGerald GA4, Durham TB3, Hammond CD3, Sloop KW3, Skarke C5, Schopfer FJ6, Wheeler MB. (PubMed)

Gamma-linolenic Acid Reduces the Risk of Non-Ischemic Heart Failure

By Kyle J. Norton

The heart is a four-chambered, hollow muscle and a double-acting pump located in the chest between the lungs is a muscular organ in the human body.

The heart formed an important part of the circulatory system that pumps blood through the blood vessels to nourish the body and assist in the removal of metabolic wastes.

Non-ischemic Heart Failure is a type of heart failure that is not associated with ischemic heart failure.

According to the statistic provided by the American Heart Foundation, on average, an American dies of CVD every 38 seconds. Cardiovascular disease (CVD) accounted for 840,678 deaths in the US in 2016 and the condition also claims more lives each year than all forms of cancer and chronic lower respiratory disease combined

In 2016, cardiovascular diseases cause the death of 2,303 deaths each day, in the US.
Cardiovascular disease is defined as medical conditions affecting the cardiovascular system, including heart, blood vessels(arteries and veins).

Ischemic heart disease is defined as a condition of reduced blood supply of the heart muscle, as a result of coronary artery disease caused by plaque building up in the arteries.

Heart failure is a medical condition characterized by insufficiently maintaining blood flow to meet the body's needs, inducing symptoms of 
* Shortness of breath and excessive tiredness are caused by the congestion in your lungs in the process of inhaling oxygen and exhaling carbon dioxide.
And* Leg swelling is a condition caused by fluid to back up in your lungs and in other parts of your body such as your ankles.

Believe it or not, approximately 600, 000 Canadian are living with heart failure or 16% of the entire population.

Gamma-linolenic acid is a phytochemical in the group of Omega-3, 6,9 fatty acids, belongings to the class of Lipids, found abundantly in evening primrose, borage, blackcurrant, etc.

On finding a potential plant that processes anti-heart diseases activity researchers examined the effect of polyunsaturated fatty acids (PUFAs) on heart failure (HF).

The study included 50 patients with stable non-ischemic HF who underwent CPETs at our hospital. 

According to the results of the analysis of the relationships between PUFAs and echocardiographic findings as well as CPET and other test parameters in patients' data.
* Correlations were significantly negative between dihomo-γ-linolenic acid (DGLA) + arachidonic acid (AA) and heart failure.

* Minute ventilation versus carbon dioxide production (VE/VCO2) slope, were positive between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and VE/VCO2 slope in heart failure.

* More profoundly, eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) were not significantly correlated with the CPET parameters.

Based on the evidence, researchers said, " Low levels of circulating DGLA+AA and AA among PUFAs were associated with decreased exercise responses in patients with stable non-ischemic HF".

Taken altogether, potato may be considered a functional food for the prevention and treatment of non-ischemic heart failure, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Relationship between Circulating Polyunsaturated Fatty Acid Levels and Exercise Responses of Patients with Non-ischemic Heart Failure by Izumida S1, Kawano H1, Muroya T2, Motokawa T1, Akashi R1, Yonekura T1, Morimoto Y3, Yano Y3, Ikeda S1, Maemura K. (PubMed)

Beta-Sitosterol Inhibits the Melanoma Brain Metastasis

By Kyle J. Norton

Cancer is a class of diseases associated with irregular cell growth on the tissue of the specific organ.

Most cases of invasive cancer can spread to other organs in the body via lymph or blood.

According to the statistics provided by the Cancer Institue, between n 2011–2015, the number of new cases of cancer is 439.2 per 100,000 men and women per year (based on 2011–2015 cases).

The number of cancer deaths (cancer mortality) is 163.5 per 100,000 men and women per year.

Under normal circumstances, cell growth is a natural process without even notice, every day millions of cells grow to replace millions of dead cells and to keep our body in balance and healthy.

Melanoma is a kind of skin cancer but less common to other skin cancer as a result of malignancy of melanocytes, which is the cell produced dark pigment for your skin. 

Approximately 120,000 new cases of melanoma in the US are diagnosed in a year. Melanoma tends to spread along the skin in most of the cases, but also can grow down to the deeper layers of the skin. At the later stage, it can spread to distant parts of the body, including organs.

Melanoma brain metastasis is secondary cancer in the brain that causes by the spreading of melanoma.

Approximately, 20% of patients are found to have brain metastasis at the time of diagnosis of metastatic melanoma, and more than 50% develop brain metastasis during the course of the disease.

Brain metastases are a frequent and often deadly problem in patients with advanced melanoma. According to the statistics, patients with melanoma brain metastasis have an average survival of only 4 months.


Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention of cancer spreading, researchers elucidated the effects of β-sitosterol, a well-tolerated and brain-penetrable phytosterol on BRAF-mutant melanoma brain metastases.

According to the results of the differentiation,
* β-sitosterol attenuates melanoma cell growth in vitro and also inhibits brain metastasis formation in vivo.

* The efficacy of β-sitosterol was linked to mitochondrial interference.

* β-sitosterol effectively reduced mitochondrial respiratory capacity, mediated by an inhibition of mitochondrial complex I associated with the levels of oxidative stress that induce apoptosis in tumor cells.

* More importantly, on the large-scale analyses of human melanoma brain metastases, Beta-Sitosterol played a significant role in mitochondrial complex I compared to brain metastases from other cancers.

* The combination of vemurafenib with either β-sitosterol or a functional knockdown of mitochondrial complex I completely abrogated BRAF inhibitor resistance.

Based on the findings, researchers said, "β-sitosterol represents a promising adjuvant to BRAF inhibitor therapy in patients with or at risk for, melanoma brain metastases".

Beta-Sitosterol may be considered a remedy in a BRAF inhibitor therapy in patients with, or at risk for, melanoma brain metastases, pending to the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis by Sundstrøm T1,2,3, Prestegarden L1,2,4, Azuaje F5,6, Aasen SN1,7, Røsland GV8, Varughese JK1, Bahador M1, Bernatz S9, Braun Y9, Harter PN9, Skaftnesmo KO10, Ingham ES11, Mahakian LM11, Tam S11, Tepper CG12, Petersen K13, Ferrara KW11, Tronstad KJ8, Lund-Johansen M2,3, Beschorner R14, Bjerkvig R1,5, Thorsen F. (PubMed)