Ursolic Acid, An Adjunct Therapy for the Treatment of Liver Cancer

By Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.

The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes and produces vitamin D and steroid hormones.

Liver disease is a class of medical conditions characterized by the reduction partly or completely the function of the liver, including liver failure.

Additionally, the liver also inhibits oxidative stress by producing the antioxidant enzyme that counters the expression of free radicals in the body

Liver cancer is a medical condition characterized by out of controlled growth of hepatocellular cells in the liver. Most cases of liver cancer start in the cells on the surface of the inner lining of the liver tissue, before penetrating into deeper layers to form a tumor.

At the advanced stage, primary liver cancer can also travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.

Since the liver is an organ with soft tissue with less nerve, most liver cancer patients are diagnosed in the later stage of cancer.

According to the statistic, liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide. In the US, approximately 42,030 new cases including 29,480 in men and 12,550 in women will be diagnosed with liver cancer. The liver cancer also will cause of 31,780 American, including 21,600 men and 10,180 women in 2019.

Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.

The most common symptoms of liver cancer are abdominal pain, tenderness, easy bruising or bleeding, enlarged abdomen, jaundice, severe pain, particularly in the later stage and drowsiness and confusion accompanied by the general symptoms shared by other types of cancer.

Ursolic acid is a phytochemical in the subclass of Triterpenoid, belongings to the group of Terpenes found abundantly in apples, basil, bilberries, cranberries, peppermint, lavender, oregano, hawthorn, prunes., etc.

On finding a potential phytochemical for the treatment of liver diseases, researchers examined the effects of a developed drug delivery system of UA-loaded polymer micelles (UA-PMs) to overcome the disadvantages of UA in clinical application in enhancing antitumor effect on liver cancer.

According to the analysis,
* UA-PMs could markedly inhibit the proliferation and migration of HepG2 cells.

* In vivo study showed that UA-PMs could significantly inhibit the growth of H22 xenograft and prolong the survival time of tumor-bearing mice.

In other words, researchers said, "UA-PMs possess great potential in liver cancer therapy and may enlarge the application of UA in clinical therapy".

Taken altogether, ursolic acid may be considered adjunct therapies in the treatment of liver cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Polymeric micelles loading with ursolic acid enhancing anti-tumor effect on hepatocellular carcinoma by Zhou M1, Yi Y2, Liu L2, Lin Y2, Li J2, Ruan J3, Zhong Z. (PubMed)

Gamma-Linolenic Acid, A Potential Treatment of Dermatitis in Vitro

By Kyle J. Norton

Dermatitis is condition associated skin irritation that involves itchy, dry skin or a rash on swollen, reddened skin.

Contact dermatitis is a skin condition with symptoms of a red, itchy rash caused by direct contact with a substance or an immune overreaction against contact allergens.

Many chemicals and nonchemicals substances have been found to induce abnormal reactions, including cosmetics, fragrances, jewelry, and plants.

Most cases of contact dermatitis are nonlife-threatening, however, the condition can induce certain discomforts, particularly in people with an allergic reaction to other conditions.

Contact dermatitis can be healed within a week or 2. The condition can be preventable if the cause is identified.

Besides the common symptoms of a red, itchy rash on the skin, some people may experience more serious symptoms including crusting swelling, burning or tenderness skin.

Atopic dermatitis or eczema is an inflammatory condition associated with red and itchy skin.

Most cases of atopic dermatitis are found in children. However, adults may also get it too. Skin irritation is found more often in children compared to adults.

The causes of atopic dermatitis are unknown. Some researchers suggested that certain risk factors such as genetic preposition and abnormal function of the immune system and environment conditions may be involved in the development of the disease.

Conventionally, dermatitis is treated by

* Steroid creams or ointments for soothing the rash.

* Oral medications such as oral corticosteroids for reducing inflammation, antihistamines to relieve itching or antibiotics to fight a bacterial infection.

Gamma-linolenic acid is a phytochemical in the group of Omega-3, 6,9 fatty acids, belongings to the class of Lipids, found abundantly in evening primrose, borage, blackcurrant, etc.

On finding a potential plant that processes anti-skin disease activity, researchers examined the effect of Dihomo-γ-linolenic acid (DGLA, C20: 3n-6), an anti-inflammatory agent on dermatitis.

According to the results of the analysis of yeast Saccharomyces cerevisiae strain as a DGLA synthesis
* Oral intake of this yeast significantly suppressed inflammatory reactions, compared to no such suppression that was observed by the intake of 25 times the amount of purified DGLA.

* Yeast Saccharomyces cerevisiae strain as a DGLA synthesis was considered to be a simple and efficient way to suppress inflammation.

* Furthermore, the synthesis compound also was effective against allergic contact dermatitis (ACD).

Taken altogether, -γ-linolenic acid may be considered a remedy for the prevention and treatment of dermatitis, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Oral administration of whole dihomo-γ-linolenic acid-producing yeast suppresses allergic contact dermatitis in mice by Watanabe N1, Teradu S1, Ohtani M1, Uemura H. (PubMed)

Oleanolic Acid, The Promising Cancer Preventive Remedy

By Kyle J. Norton

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Cancers are the second leading cause of death worldwide besides heart diseases.

Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.

Angiogenesis is the process that develops new blood vessels from pre-existing vessels by invasive tumors to provide energy(nutrition and fluids) for cancerous cells growth and proliferation.

Oleanolic acid is a phytochemical in the subclass of Triterpenoid, belonging to the group of Terpenes found abundantly in honey mesquite, garlic, java apple, clove, etc.

On finding a potential plant for the treatment of chronic diseases, researchers examined the anti-cancer effect of Oleanolic acid (OA), a common pentacyclic triterpenoid.

According to the results of the analysis,
* Oleanolic acid exerted its effects as an inhibitor of the cellular inflammatory process, and the inducer of phase 2 xenobiotic biotransformation enzymes associated with cancer initiation.

* OA demonstrated its main anticancer effects mediated by caspases, 5' adenosine monophosphate-activated protein kinase in cellular energy homeostasis, extracellular signal-regulated kinase 1/2 in the regulation of cancer cell meiosis, mitosis, and postmitotic functions, matrix metalloproteinases in organogenesis, growth and normal tissue turnover, pro-apoptotic Bax.

* OA also promoted the overexpression of reactive oxygen species/apoptosis signal-regulating kinase 1/p38 mitogen-activated protein kinase, nuclear factor-κB, in the induction of cancer cytotoxicity.

Collectively, researchers said, " In this work, we critically review the scientific literature on the molecular targets of oleanolic acid implicated in the prevention and treatment of several types of cancer".

Taken altogether, potato may be considered a functional food for the prevention and treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy by Žiberna L1, Šamec D2, Mocan A3,4, Nabavi SF5, Bishayee A6, Farooqi AA7, Sureda A8, Nabavi SM. (PubMed)

Antioxidants Triterpenoids, a Natural Antihistamines

By Kyle J. Norton

Histamine, found within granules of basophils and mast cells (>90% of body stores) is a biogenic amine and an organic nitrogen compound that occurs to various degrees in many foods such as cherries to about 0.17-13.46 ng/g, bananas, and grapes, rice, and cereals, herbs, olive oil, wine, beer, etc.

In healthy persons, dietary histamine can be rapidly detoxified by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity(a). The hormone, as a neurotransmitter is involved in regulating physiological function in the gut and immune response to foreign pathogens.

Antihistamines are medicines that treat allergic rhinitis and other allergies associated with relief from nasal congestion, sneezing, or hives caused by pollen.

Health benefits of hormone histamine may include

* Histamine and motivation
Brain histamine may affect a variety of different behavioral and physiological functions; however, its role in promoting wakefulness has overshadowed its other important functions.

*  Role of histamine in motion sickness

The Faculty of Pharmaceutical Sciences, University of Tokyo, found that shaking the animals for 2 min increased HA contents in telencephalon and diencephalon without significantly changing the t-MH levels. alpha-Fluoromethylhistidine (alpha-FMH), which is presumed to deplete the neuronal HA, tended to raise the HA levels. alpha-FMH slightly alleviated the vomiting response to motion stimulus and suppressed the HA increase in diencephalon caused by shaking.

* Histamine and IgE-mediated diseases

The release of preformed histamine from mast cells causes increased vascular permeability via smooth muscle contraction and development of a wheal; inflammatory mediators initiate a neural reflex causing vasodilatation, leading to erythema (the flare)(19).

* Histamine in addiction and addiction-related behaviors

Research conducted during the past decade demonstrated that the ability of many antihistaminic drugs to potentiate addiction-related behaviors essentially results from non-specific effects and does not constitute a valid argument in support of an inhibitory function of histamine on reward processes.

* Histamine and stimulate gastric acid secretion
Ghrelin, a novel growth hormone-releasing peptide, is present in the rat and human stomach and is known to stimulate the acid secretion and stomach motility. In the study to elucidate the role of histamine in ghrelin-induced acid secretion in the rat stomach. Intravenous administration of ghrelin at 0.8 to 20 microg/kg dose-dependently increased gastric acid secretion, as measured by the gastric lumen perfusion method.

* Histamine and neurotransmitter release
In the study to investigate the effect of histamine-3 (H(3)) receptors, expressed in the tuberomammillary nucleus (TMN) of the hypothalamus and in the prefrontal cortex (PFC), on histamine neurotransmission in the rat brain, showed that systemic administration of the selective H(3)-agonist, immepip, decreases, and the reverse H(3) /H(4)-agonist, thioperamide, increases the firing activity of histamine neurons in the TMN and the release of histamine in TMN and PFC.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of inflammatory diseases, researchers examined the antihistaminic activity of triterpenoids isolated from Bursera cuneata.

The study included phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induced edema in mice treated by 3 extracts of different polarities.

According to the chemical analysis,
* The dichloromethane extract had the highest anti-inflammatory effect (89.1 ± 2.2% inhibition) over that of the hexane (53.3 ± 1.2%) and methanolic (77.4 ± 1.8%) extracts at a dose of 0.1 mg/ear.

* The FS-3 fraction, obtained from the dichloromethane extract, comprised triterpenes β-sitosterol (1), α-amyrin (2), moronic acid (3), and ursolic acid (4), and all the compounds showed significant activity in comparison with that of indomethacin (41.5 ± 0.6%) at 0.1 mg/mouse ear.

* Moronic acid displayed the highest inhibitory effect (68.1 ± 1.3%).

* Moronic acid was the most active (73.3 ± 1.1%, indomethacin 33.8 ± 0.8%) on histaminic activity.

Finally, moronic acid was found to be a principal anti-inflammatory and antihistaminic compound present in B. cuneata. 

Furthermore, in RAW 264.7 cell stimulated with LPS, moronic acid at 30 and 15 mg/mL a significant reduction of ON was observed (36% and 28% respectively) but had no significant effect on TNFα production.

Based on the findings, researchers said, "the organic extracts and isolated compounds from the aerial parts of B. cuneata had topical anti-inflammatory and antihistaminic activities in vivo, but in vitro only modified the production of ON in RAW cells. The results of this study validated the use of B. cuneata in folk medicine for the treatment of inflammatory diseases".

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of bacterial infectious diseases, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-inflammatory and antihistaminic activity of triterpenoids isolated from Bursera cuneata (Schldl.) Engl by Figueroa-Suárez MZ1, González Christen J2, Cardoso-Taketa AT3, Gutiérrez Villafuerte MDC4, Rodríguez-López V. (PubMed)
(2) Antihistaminic and antiallergic actions of extracts of Solanum nigrum berries: possible role in the treatment of asthma by Nirmal SA1, Patel AP, Bhawar SB, Pattan SR. (PubMed)
(3) The Effects of Hormone Histamine (3) by Kyle J. Norton

Carotenoids Inhibit the Risk and Progression of Chronic Low-Grade Systemic Inflammation

By Kyle J. Norton

Inflammation is a natural defense of the immune system that protects the body against the insult from the foreign invasion.

Acute inflammation occurs quickly or within the hours and lasts a few days or weeks and the damaged tissues are healed themselves after all pathogens are killed off.

However, if the immune system can not completely eradicate all invaders in the acute phase of infection, it will compromise, leading to chronic low-grade inflammation, a major cause of cardiovascular disease, arthritis, and diabetes.

Chronic inflammation is a low-grade inflammation caused by the inability of the immune system to eliminate the invasive pathogens that occurred in the acute phase of infection.

Any inflammation that lasts more than 8 weeks is considered chronic inflammation.

Believe it or not, worldwide, 3 of 5 death are results from chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes.

In the US, chronic inflammatory diseases affect more than 50 million Americans each year.

Diseases associated with low-grade inflammation include diabetes and cardiovascular obesity, depression, and chronic pain.

Conventionally, Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common medical drugs such as aspirin. ibuprofen in reducing inflammation associated with pain-relieving.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the relationship between dietary patterns, circulating carotenoid and tocopherol concentrations, and biomarkers of chronic low-grade systemic inflammation in a 10-year longitudinal study of Scottish postmenopausal women.

According to the assessment of FFQ during 1997-2000 (n 3237, mean age 54·8 (SD 2·2) years). Participants (n 2130, mean age 66·0 (SD 2·2) years) returned during 2007-11 for follow-up, 

* The past 'prudent' dietary pattern showed a decrease of serum concentrations of hs-CRP and IL-6 (which decreased across the quintiles of the dietary pattern; P= 0·002 and P= 0·001, respectively; ANCOVA), 

* The Inflammatory biomarker concentrations were decreased markedly across the quintiles of carotenoids component score (P< 0·001 for hs-CRP and IL-6, and P= 0·016 for E-selectin, compared to the increase of inflammatory biomarkers in contemporary dietary patterns.

* More precisely, prudent dietary pattern and carotenoid component scores were negatively associated with serum hs-CRP concentration (unstandardised β for prudent component: -0·053, 95% CI -0·102, -0·003; carotenoid component: -0·183, 95% CI -0·233, -0·134).

Where, a prudent dietary pattern (which reflects a diet high in the intakes of fish, yogurt, pulses, rice, pasta, and wine, in addition to fruit and vegetable-rich with carotenoids diet.

In other words, the prudent diet with rich of carotenoids is associated with a reduced risk of chronic inflammatory diseases.

Taken altogether, carotenoids may be considered an adjunct therapy in the treatment of diseases associated with chronic low-grade inflammation, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Patterns of dietary intake and serum carotenoid and tocopherol status are associated with biomarkers of chronic low-grade systemic inflammation and cardiovascular risk by Wood AD1, Strachan AA1, Thies F1, Aucott LS1, Reid DM1, Hardcastle AC2, Mavroeidi A3, Simpson WG1, Duthie GG4, Macdonald HM. (PubMed)

Pancreatin, the Mixture that Improves the Absorption of Fat, Protein, and Energy In Patients with Pancreatic Insufficiency

By Kyle J. Norton

The pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen. By secreting pancreatic juice to the small intestine, the pancreas helps to break down carbohydrates, proteins, and lipids.

Traditional Chinese medicine views the pancreas, a vital organ is responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our body.

More precisely, the functions of the pancreas including

* Production of enzymes digest fat, protein, and
carbohydrates.

* production of juices combined with juices from the intestines helps to do the job of breaking down protein, carbohydrates and fat, therefore, it plays an important role in maintaining good health.

*  Production of insulin, which is important in regulating the amount of sugar or glucose in the blood.

Pancreatic insufficiency is a medical condition in which the pancreas is not able to produce and/or transport enough digestive enzymes to break down food in the intestine.

Two of the most common causes of pancreatic insufficiency (EPI) are cystic fibrosis and chronic pancreatitis.

Other diseases associated with the condition are irritable bowel syndrome (IBS), peptic ulcer disease, gallbladder diseases, and inflammatory bowel problems.

Conventionally, depending on the severity of pancreatic insufficiency, the main treatment is to replace the levels of a pancreatic enzyme using pancreatic enzyme replacement therapy, or PERT.

 Pancreatin, are commercial mixtures of amylase, lipase, and protease.
On finding a potential phytochemical for the prevention and treatment of pancreatic diseases, researchers elucidated the effects of neutral sterols and short-chain fatty acids on high-lipase pancreatin in Japanese patients with pancreatic insufficiency whose dietary fat consumption is low.

The study included 15 patients with chronic pancreatitis complicated by steatorrhea who consumed an average of 48 g of dietary fats a day were given 3 g of high-lipase pancreatin (lipase, 379,800 USP U/g), at each meal (the total daily dose is 9 g) for a mean duration of 28.5 days.

According to the fecal output and fecal fat neutral sterol, bile acid, and short-chain fatty acid excretion analysis,

* Pancreatin administration resulted in significant reductions (P < 0.01) in fecal output (from 243.2 to 149.1 g), excretion of fecal fat,

* Furthermore, animal sterols (from 816.3 to 604.6 mg), and short-chain fatty acids were reduced (from 12.3 to 3.9 g), and (from 52.6 to 18.5 mM), respectively.

Interestingly, the administration of pancreatin showed no marked changes in fecal excretion of beta-sitosterol (a plant sterol), bile acids, or the hydroxy fatty acid fraction.

In other words, Pancreatin improved patients with pancreatic insufficiency to absorb fat, protein, and energy.

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of obesity-related chronic inflammation, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of high-lipase pancreatin on fecal fat, neutral sterol, bile acid, and short-chain fatty acid excretion in patients with pancreatic insufficiency resulting from chronic pancreatitis by Nakamura T1, Tandoh Y, Terada A, Yamada N, Watanabe T, Kaji A, Imamura K, Kikuchi H, Suda T. (PubMed)

Tocopherols, the Natural Anti-hypercholesterolemic Phytochemicals

By Kyle J. Norton

The liver is a large internal organ of the human body that protects us by filtering the blood that comes from the digestive system before passing to other parts of the body.

In other words, if the liver was damaged due to toxicity, the blood will be toxic, affecting the function of all organs and tissues in the body.

The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes and produces vitamin D and steroid hormones.

Cholesterol found in our body is needed for our body to build cell walls, hormones, and vitamin D, and create bile salts that aid digestion. However, too much of them, in most cases due to the intake of animal protein can cause plaques built up on the arterial wall, the major cause of heart disease and stroke.

More precisely, if levels of low-density lipoprotein are high compared to high-density lipoprotein which returns the accessed cholesterol back to the liver, you have high blood cholesterol.

In other words, healthy blood cholesterol is any level with either less than or equal to 4 (low-density lipoprotein/ 1 (high-density lipoprotein).

According to the statistics, in 2015-2016, by age and gender, a total of 12.4 percent of adults aged 20 years and over had high cholesterol in the United States.

Hypercholesterolemia is a condition characterized by abnormally high levels of cholesterol in the bloodstream.

In other words, the condition is caused by either overexpression of low-density lipoprotein (LDL) or low levels of high-density lipoprotein (HDL).

Similar to high blood pressure, people with hypercholesterolemia are asymptomatic. Patients with familial hyper cholesterol may experience symptoms of chest pain with activity. xanthomas, and cholesterol deposits around the eyelids.

The most common complications associated with uncontrolled hypercholesterolemia are carotid artery disease, coronary heart disease, including angina or heart attack, peripheral artery disease, and stroke.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of diseases associated with high blood cholesterol, researchers examined the antioxidant defense activity of alpha-tocopherol in familial hypercholesterolemia and the effects of lipoprotein apheresis.

The study included a group of hypercholesterolemic patients (n = 14) that were treated by lipoprotein apheresis was compared to healthy adult normolipidemic controls to induce the decrease of tocopherol in serum and lipoprotein fractions with no change of the content of in membrane alpha-tocopherol.

According to the analysis of a simple isocratic reversed-phase HPLC method that has been developed and validated for the determination of alpha-tocopherol in human erythrocytes in a clinical setting, alpha-tocopherol significantly decreased lipoperoxidation as revealed by serum TBARS, representing end products of lipid peroxidation which increased from third day afterward and remained significantly higher in comparison to controls until the next LDL-apheresis.

More precisely, the phytochemical demonstrated an aggressive lipid-lowering procedure with lipoprotein apheresis associated with a favorable transient decrease of lipoperoxidation.

In other words, alpha-tocopherol inhibited the lipoperoxidation in the induction of hypercholesterolemia in the tested patients through its antioxidant activity.

 

After talking about other factors into account, researchers said, "Simultaneously the cell membrane-bound antioxidative defense mechanisms as reflected by the content of alpha-tocopherol in human erythrocyte membrane were not depressed in spite of its decreased plasma lipid carrier".

Taken altogether, tocopherols may be considered an adjunct therapy in the prevention and treatment of hypercholesterolemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antioxidant defense system in familial hypercholesterolemia and the effects of lipoprotein apheresis by Blaha V1, Blaha M2, Solichová D3, Krčmová LK3, Lánská M2, Havel E3, Vyroubal P3, Zadák Z3, Žák P2, Sobotka L. (PubMed)