Korean Cabbage Inhibits the Initiation of Atherosclerosis

By Kyle J. Norton

The heart formed part of the circulatory system is a muscular organ that pumps blood through the blood vessels to supply oxygen and nutrients and removal of metabolic wastes.

Heart disease is a group of medical conditions casued by the narrowed or blocked blood vessels that can lead to a heart attack, coronary heart disease or stroke.

According to the statistic from the CDC, approximately over 600,000 Americans die of heart disease every year. The condition is a leading cause of death in both men and women.

Atherosclerosis is a medical condition associated with plaque building up in the arteries, leading to the narrowing of the arterial function in the transportation of oxygenated blood to the heart and other blood of the body.

Plaques are substances made up of the accumulated fat, cholesterol, calcium, and other substances found in the blood, including cadmium.

Long-term accumulation of plaque can also cause hardening and stiffing arterial walls can lead to the blockage of the arteries and risk of heart disease depending on the location of the blockage.

Most people in the early stage of atherosclerosis do not experience any symptoms. However, as the condition progresses and the location affected, patients may develop chest pain, shortness of breath, sweating, and anxiety.

Most common causes of atherosclerosis are the imbalance of the ratio of bad cholesterol and good cholesterol in the blood, long-term smoking, obesity, an increase in age, obesity and some medical conditions, such as diabetes and high blood pressure.

Cabbage is a species of Brassica oleracea belong to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem which is crowded a mass of leaves, usually green but in some varieties, it may be red or purplish.

With an aim to find a natural food for the prevention and treatment of heart disease, researchers examined the effect of effects of 3-(4'-hydroxyl-3',5'-methoxyphenyl)propionic acid (HDMPPA) originating from Korean cabbage on the prevention of atherosclerosis.

The experiments included 21 3-month-old rabbits fed an atherogenic diet containing 0.5% (w/w) cholesterol and 10% (w/w) coconut oil, whereas another two groups were given an atherogenic diet with intravenous injection of either HDMPPA or simvastatin (0.33 mg/kg/day) for 4 weeks.

According to the tested analysis, HDMPPA injected group not only showed a significant effect on the inhibition the oxidative modification of low-density lipoprotein (IC 50 = 1.4 microg/mL) but also increased 2,2'-diphenyl-1-picrylhydrazyl radical scavenging activity (IC 50 = 0.78 microg/mL) in a dose-dependent manner.

In hypercholesterolemic rabbits, the thickness of the innermost tunica (layer) of an artery or vein in the HDMPPA group was significantly reduced (control versus HDMPPA, 42%; simvastatin, 38%) without affecting the levels of cholesterol.

Furthermore, the plasma of the HDMPPA group exerted a significantly decreased activity against oxidation compared to that of the control group.

More precisely, HDMPPA also inhibited the generation of vascular reactive oxygen species by inhibiting the levels of cyclooxygenase-2 in the initiation of inflammation.

Based on the findings, researchers said, "HDMPPA prevents the development of aortic atherosclerosis in high-cholesterol-fed rabbits. The antiatherosclerotic effect of HDMPPA may be due to an antioxidative effect at a low dose without cholesterol-lowering effects".

Taken altogether, Korean cabbage may be considered supplements for the prevention and treatment of atherosclerosis, pending to the confirmation of the larger sample size and multicenter human study.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3-(4'-hydroxyl-3',5'-dimethoxyphenyl)propionic acid, an active principle of kimchi, inhibits development of atherosclerosis in rabbits by Kim HJ1, Lee JS, Chung HY, Song SH, Suh H, Noh JS, Song YO. (PubMed)
(2) Beneficial effects of polyphenol-rich Olive Oil in patients with early atherosclerosis by RJ Widmer,*,1 MA Freund,*,1 AJ Flammer,1 J Sexton,1 R Lennon,1 A Romani,2 N Mulinacci,2FF Vinceri,2 LO Lerman,1 and A Lerman. (PMC)

Lycopene Processes Anti OverGrowth of Candida Albicans

By Kyle J. Norton

Fungal infectious disease occur mostly in patients with a weakened immune system characterized by the disease caused by overexpression of specific fungal.

Most common mild fungal skin diseases can induce symptoms of a rash that may go away if the fungal infection is cured.
Candida is a class of yeasts that cause fungal infections worldwide. Under normal conditions, candida does not cause any health issue if they live outside of the body including on the surface of the skin. However, Candida can cause a significant health problem if they grow out of control in the deeper parts of the body, leading to candidiasis.

Candida albicans is a member of a large group of an organism whose cells contain complex structures enclosed within the membranes, including yeast and mold that live among the gut flora in the human mouth and gastrointestinal tract.

Oral candidiasis is an oral condition infected by the fungal C. albicans found mostly in people with a weakened immune system including patients who are taking the immune-suppressive medicine.

Biofilms are microbial communities in which cells stick to each other and often also to a surface.

Symptoms of oral Candida overgrowth include worse in the damp day, persistence drowsiness, lack of coordination, headaches, mood swing, loss of balance, rashes, bad breath, dry mouth, and postnasal drip.

If you experience some of the aforementioned symptoms, please make sure you check with your doctor for early treatment.

There are many risk factors associated with Candida overgrowth including medical conditions that cause weakened immune system, inhalant medicine, low level of stomach acids, and pregnancy.

Some researchers suggested aging due to a weaken the immune system may be one of the major risk factors that cause Candida overgrowth

Dr. Aikaterini Flevari, the lead scientists said, "Candida species remain the most important cause of opportunistic infections worldwide, affecting predominantly patients over 65 years old, while they are considered to be the fourth most common cause of nosocomial bloodstream infections".

And, "The rapidly growing elderly population has specific physiological characteristics, which makes it susceptible to colonization and subsequent infection due to Candida species".

Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potential compound for the treatment of fungal infection, researchers examined the role of lycopene on C. albicans.

In fungal infection, lycopene exerted potent antifungal effects on pathogenic fungi, including C. albicans in an energy-independent manner.

In Candida albicans induced by fetal bovine serum (FBS) inhibited C, albicans by causing significant membrane damage and blocking the normal budding process.

In other words, the injection of lycopene induced C. albicans apoptosis by the destruction of membrane integrity.

Based on the findings, researchers said, "indicates that lycopene has considerable antifungal activity, deserving further investigation for clinical applications".

Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of C. albicans infection, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You.  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Damage to the cytoplasmic membrane and cell death caused by lycopene in Candida albicans by Sung WS1, Lee IS, Lee DG. (PubMed)
(2)

Treatment of invasive candidiasis in the elderly: a review by Aikaterini Flevari,1 Maria Theodorakopoulou,1 Aristea Velegraki,2 Apostolos Armaganidis,1 and George Dimopoulos. (PMC)

Brussels Sprouts Inhibits Renal Damage in Patients with Hypertension

By Kyle J. Norton

Hypertension is a condition of abnormally high blood pressure in the bloodstream. Hypertension a member of the cluster conditions of metabolic syndrome associated with an increased risk of cardiovascular disease and diabetes.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

According to the statistics provided by the American Heart Association, approximately, 103 million U.S. adults have high blood pressure, or 1 in 2 adults in the US have the syndrome.

The kidneys are two bean-shaped organs located just below the rib cage, one on each side of your spine.

The kidneys formed a second detoxed organ in the body after the liver not only plays an essential role in regulating electrolytes, blood pressure, maintains acid-base balance, produces hormone calcitriol, renin, and erythropoietin,... but also filters blood that passes into the tubules. In the Urinary system, kidneys reabsorbed some necessary substances back into the blood, while waste, such as urea and ammonium are deposited into pelvis then into the ureter to the bladder for secretion.

Kidney disease is a condition that reduces the function of the kidney acutely or gradually.

Kidney damage is a condition that causes the reduced function of the kidney. Over time untreated kidney damage can induce the formation of scars. Over-expression of kidney scars can lead to kidney disease and kidney failure in severe cases.

According to the statistics, approximately 14 percent of the US population suffer some forms of chronic kidney disease (CKD), including 661,000 cases of kidney failure.

Believe it or not, almost half of the individuals with CKD also have diabetes and/or self-reported cardiovascular disease (CVD).


Blood in urine, protein in the urine, kidney stones, kidney infection, kidney pain, hepatitis C and other forms of kidney diseases are signs of kidney disease that can lead CKD.

With an aim to find a natural food for the prevention of stroke, researchers examined the effect of Brussels sprouts on high-sodium/low-potassium-fed stroke-prone spontaneously hypertensive animal model.

Stroke-prone spontaneously hypertensive rat (SHRSP) received the Japanese diet for 4 weeks included in the study was divided into

* Nontreatment group.

* SHRSP group received a Japanese diet and B. oleracea.

* A third group received a Japanese diet, B. oleracea, and PPARα inhibitor (GW6471).

* A group of SHRSP fed with regular diet served as control.

According to the tested analysis, compared to a regular diet, group treated with Japanese diet (high-sodium/low-potassium) showed to induce the increases of oxidative stress, inflammation, and proteinuria, along with glomerular and tubular damage.

The (AMPK/UCP2) pathway associated with the inhibition of ROS production and inhibits palmitate-induced apoptosis in endothelial cells was significantly suppressed by the Japanese diet.

However, Japanese diet-induced overexpression of oxidative stress accumulation, inflammation, renal damage, and proteinuria was totally prevented by the administration of Brussels sprouts.

Additionally, injection of Brussels sprouts also promoted the expression of antioxidant enzymes produced by the host observed by the increased level of a gene associated with drug toxicity without affecting the systolic blood pressure (SBP).
 

Taken altogether, Brussels sprouts may be considered supplements for the prevention of renal damage progression in hypertension, pending to the confirmation of the larger sample size and multicenter human study.

Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective effects of Brassica oleracea sprouts extract toward renal damage in high-salt-fed SHRSP: role of AMPK/PPARα/UCP2 axis by Rubattu S1, Di Castro S, Cotugno M, Bianchi F, Mattioli R, Baima S, Stanzione R, Madonna M, Bozzao C, Marchitti S, Gelosa P, Sironi L, Pignieri A, Maldini M, Giusti AM, Nardini M, Morelli G, Costantino P, Volpe M. (PubMed)

Herbal Ashwagandha Kills Osteosarcoma Cells in Vitro

By Kyle J. Norton

Osteosarcoma is a type of bone cancer found mostly in teenagers and people over age 60.

Most cases of osteosarcoma are associated with genetic syndromes. In other words, Osteosarcoma is associated with a genetic preposition inherited from the parent.

According to the statistic from the American Cancer Society, each year, approximately 800 to 900 new cases of osteosarcoma are diagnosed in the United States with half of these are in children and teens.

The exact causes of osteosarcoma are unidentified. However, epidemiologically, besides gene expression, an unhealthy lifestyle such as body weight, physical activity, diet, and tobacco, gender, age, height, ethnicity and exposure to bone radiation are also some prevalent factors found in patients with the disease.

Dr. Jeff W. Martin, the lead scientist at the Hospital for Sick Children and Queen's University wrote, "The etiology of this often aggressive cancer is currently unknown because complicated structural and numeric genomic rearrangements in cancer cells preclude the understanding of tumor development.",

And, " few consistent genetic changes that may indicate effective molecular therapeutic targets have been reported. However, high-resolution techniques continue to improve knowledge of distinct areas of the genome that are more commonly associated with osteosarcomas".

The overall 5-year survival rate for children and teens with osteosarcoma is 70%. If cancer has spread to the lung, the 5-year survival rate is only 40% comapred to localized cancer between 60% to 80%.

Conventionally, most cases of osteosarcoma are o treated with a combination of surgery, chemotherapy and radiation therapy.

In patients with high-grade tumors, before surgery, neo-adjuvant therapy may be necessary to shrink the tumor.

Ashwagandha (WA)also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the treatment of cancers, researchers examined evaluated the safety and pharmacokinetics of WA.

In Vitro, Withaferin-A (WF-A), a major bioactive compound found in WA exhibited strong antiproliferative activity against several osteosarcoma cell lines, with IC50 ranging from 0.32 to 7.6 μM. The lowest IC50 (0.32 μM).

At the lowest IC50 (0.32 μM), WF-A showed a significant effect on the inhibition of U2OS cell line, comapred to other cell lines.

Most importantly, WF-A induced ROS cytotoxicity against the tested cell lines in a dose-dependent manner and activation of cell death protein in osteosarcoma cells.

In the safety analysis if the phase I dose-escalation study, using the classical 3 + 3 design (C33D) is comprised of 72, 108, 144 and 216 mg of WA administered in two to four divided doses per day in selected patients, including 3 patients enrolled in each cohort with the last patient who was observed for at least 30 days for any dose-limiting toxicity before progressing to a higher cohort, researchers found that the formulation was generally well tolerated with no grade 3 or grade 4 adverse events were observed, however, the formulation at the tested doses caused 11 adverse events of grade 1 or grade 2 severity.

Mose common symptoms are fatigue, fever, edema, and diarrhea. No levels of WA circulation. were found in the blood plasma. The low oral bioavailability of WA was also observed during the experimental period.

Based on the findings, researchers wrote, "The formulation was well tolerated. However, WA appears to have low oral bioavailability. Further studies with improved formulations are warranted".

Taken altogether, Ashwagandha is safe and may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of osteosarcomas, pending to the result of larger sample size and multicenter study



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Safety and Pharmacokinetics of Withaferin-A in advanced stage high grade Osteosarcoma: A phase I trial by Pires N1, Gota V1, Gulia A2, Hingorani L3, Agarwal M2, Puri A. (PubMed)
(2) Withaferin-A Induces Apoptosis in Osteosarcoma U2OS Cell Line via Generation of ROS and Disruption of Mitochondrial Membrane Potential by Zhang HL1,2, Zhang H. (PubMed)
(3) The Genetics of Osteosarcoma by Jeff W. Martin,1 Jeremy A. Squire,2 and Maria Zielenska. (Hindawi)

Herbal Turmeric Processes a Strong Immunodulatroy Activity

By Kyle J. Norton

The immunomodulatory activity is a process in which the immune function is modulated to the needs of the body.

The immune system included the thymus and bone marrow, as well as secondary lymphatic tissues including spleen, tonsils, lymph vessels, lymph nodes, adenoids, skin, and liver, is the body's defense against infectious organisms and foreign invaders.

The immune dysfunction can be classified into
* The underactive immune system is also known as the weakened immune system. People with the underactive immune system are susceptible to infection, recurrent infections.

* The overactive immune system is also known as autoimmune diseases. In this case, patients suffer diseases associated with the immune system that attacks the body tissues.

In the acute phase of infection, the immune macrophages, the first line of defense stimulates the production of blood palette to cover the wound or injury and pro-inflammatory cytokines to the site of infection to kill off pathogens before they can enter the body to multiply.

Most cases of infection are stopped at the acute phase, depending on the size and penetration of the wound.

Most common symptoms of acute inflammation occurred with a short period of time such as hours is pain, redness, immobility, swelling, and heat.

Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.

However, if the immune system for whatever reason such as in people with a weakened immune system can not destroy the foreign invaders in the set period of time (3-8 weeks), it will adapt to the new change, leading to chronic low-grade inflammation.

Low-grade inflammation over time has been found to destroy cells and tissues in the affected area or organ, inducing chronic inflammatory disease, including diabetes, arthritis, and cardiovascular disease.

Out of many low-grade inflammatory risk factors, some researchers suggested that the promotion of the Western diet over the past few decades may be one of the major culprits involved in facilitating the onset of the diseases.

Dr. Klurfeld DM, the lead scientist wrote, "Diet is a component in the etiology of the two major causes of death in the United States, namely, cardiovascular disease and cancer. During the last decade, various organizations have suggested that we alter the "typical" American diet in order to decrease the incidence of these diseases even though both diseases are indisputable of multiple etiology".

And, "Most Americans can safely reduce their intake of total calories, fat, sugar, and salt. Although this can be achieved most readily on a population basis by following a form of "prudent" diet, it is premature to promise medical benefits to individuals".

In other words, if you follow the diet pattern of a high-fat diet, you are at a higher risk of low-grade inflammatory disease, compared to those who follow the diet pattern of the Mediterranean diet.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound for the enhancement of the immune system, researchers examined the effects of turmeric on immunomodulating activity.

Carp (average weight: 16.37 g) selected to the study were fed by four various concentrations of curcumin (g Kg-1): 0 g [basal diet], 5 g [T5], 10 g [T10], and 15 g [T15] were fed to the carp (average weight: 16.37 g) for 8 weeks.

According to the skin mucosal immune parameters examination, T15 fed by 15 g curcumin showed a significantly higher levels of lysozyme (36.8 ± 4.03 U mL-1) involved bacterial infections, total immunoglobulin (6.74 ± 0.5 mg mL-1, antibodies), protein level (18.7 ± 1.62 mg mL-1), alkaline phosphatase (96.37 ± 6.3 IU L-1), and protease activity (9.47 ± 0.82%) associated with the innate immune response.

Furthermore, levels of antioxidants such as superoxide dismutase (SOD) and catalase (CAT) activities were higher in T10 or T15, comapred to control.

Moreover, groups treated with curcumin also reduced tissues oxidative stress such as malondialdehyde level was decreased significantly.

More precisely, T10 and T15 exhibited immunomodulatory activity by enhancing the expression of antioxidant genes (SOD, CAT, nuclear factor erythroid 2-related factor 2) and anti-inflammatory cytokine Interleukin-10 and inhibiting the expression of pro-inflammatory cytokines such as IL-1β, tumor necrosis factor-alpha in the tested subjects.

Based on the findings, researchers wrote, "suggest that dietary supplements of curcumin at 15 g Kg-1can significantly improve the growth performance, skin mucosal and serum antioxidant parameters, and strengthen the immunity of C. Carpio".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the improvement of immunomodulatory property, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How to Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Immunomodulatory effects of turmeric: Proliferation of spleen cells in mice by Mustafa R1,2, Blumenthal E. (PubMed)
(2) Effects of bioactive substance from turmeric on growth, skin mucosal immunityand antioxidant factors in common carp, Cyprinus carpio by Giri SS1, Sukumaran V2, Park SC. (PubMed)
(3) The Western diet: an examination of its relationship with chronic disease by Klurfeld DM, Kritchevsky D. (PubMed)

Cranberry Effects on Diabetes and Hypertension Management

By Kyle J. Norton

Diabetes is a medical condition caused by not insufficient insulin entering the bloodstream.

In other words, diabetes is a condition associated with the inability of the body to use insulin properly.

Most cases of insulin insufficiency in the bloodstream in diabetes are either caused by the gradual died-off of the pancreas beta cells or insulin receptors clogged-up by fat and cholesterol.

Hallmarks of diabetes are hyperglycemia and insulin resistance.

According to the statistics, in 2017, 7.3% of Canadians aged 12 and older (roughly 2.3 million people) reported being diagnosed with diabetes.

Most common causes of diabetes are metabolic syndrome, a cluster of conditions including high blood pressure, cholesterol, and glucose, gestational diabetes, prediabetes, damage to the pancreas causes the gradual and irreversible loss of beta cells that reduce the production of insulin, and influenza a viruses

Hypertension, a condition associated with the cluster of metabolic syndrome is a medical condition associated with abnormally high blood pressure.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood and changes constantly depending on activity. However, persistent hypertension due to poor management over time can lead to diabetes and cardiovascular disease.

According to the statistics provided by the American Heart Association., nearly half of all adults in the United States are living with high blood pressure or 1 in 3 American are hypertensive.

Hypertension is leading risk factors of heart disease and stroke that cause most death in the US

Most common prevalent factors associated with the condition onset are family history, aging, being male, being overweight or obese, ethnicity, physical inactivity, unhealthy diet and medical condition such as chronic kidney disease.

Believe it or not, excessive alcohol drinking is also one of the major causes besides obesity in elevating the syndrome onset.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the management of blood pressure, researchers examined the effect of a water-soluble cranberry-based phytochemical combination with oregano, rosemary, and Rhodiola Rosea against hypertension.

According to the tested analysis, the 75% cranberry with 25% oregano combinations showed the highest antioxidant phenolics (38.9 mg/g DW) comapred to other combinations by inhibition of free radical DPPH inhibition by 73.6 %.

Furthermore, 75% cranberry and 25% Rhodiola Rosea combination had the highest alpha-glucosidase activity among the combinations. 

Alpha-amyloid associated diabetes also was associated with 75% cranberry with 25% Rhodiola Rosea combination comapred to other combinations.

Additionally, anti-ACE-I inhibitory activity against the risk of hypertension was also inhibited by the 75% cranberry with 25% rosemary comapred to other combination.

In other words, cranberry combined with other herbal medicine protects patients with diabetes and hypertension against complications by inhibiting the levels of alpha-glucosidase, alpha-amyloid and ACE-I 

Based on the results, researchers said, "The analysis of alpha-glucosidase,alpha-amylase, and ACE-I inhibitory activities suggested that inhibition depends on the phenolic profile of each unique extract and by bringing together synergistic combinations to cranberry, health beneficial functionality was enhanced".

Taken altogether, cranberry may be considered a remedy for the management of diabetes and hypertension, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Potential of cranberry-based herbal synergies for diabetes and hypertensionmanagement by Apostolidis E1, Kwon YI, Shetty K. (PubMed)

Herbal Turmeric Protects the Blood Vessels Against Vascular Inflammation

By Kyle J. Norton

Inflammation is a natural reaction of the immune system's self-protection to remove harmful stimuli, including damaged cells, irritants, pathogens... from our body.

Acute inflammatory inflammation is a result of the over-response of the immune system after sensing the injury or damage of the body through activating the protein associated with the production of pro-inflammatory cytokines.

The aim of the proinflammatory cytokines is to kill the invasive pathogens, which try to enter the body through the wound.

In the acute phase of infection, the immune system in the stimulating production of proinflammatory cytokines may induce overproduction of these cytokines can cause death or damage to the nearby cells, leading to scar formation and symptoms of localized swelling, redness and fever.

Chronic inflammation is a serious condition caused by the immune system to adapt to the new change due to its inability to kill all the invasion within a set of times.

Vasoprotection is the process to improve the function of the blood vessels, including the use of the herbal and natural remedy.

Blood vessels are the tubular structure including a vein, artery, or capillary which carries the blood through the tissues and organs pumped by the heart.

There 3 main types of blood vessel are arteries that deliver oxygen-rich blood from the heart to the tissues and organs of the body. Damage of arteries may induce coronary artery disease associated with the narrowing or blockage of the coronary arteries due to plaques accumulated in the arterial wall.

The veins that carry blood toward the heart. Chronic venous insufficiency (CVI) is a common condition associated with disease of the veins that affects up to 20 percent of adults.

The capillaries or the smallest blood vessels that have been found to induce systemic capillary leak syndrome (SCLS) is a rare acquired disorder.

Vascular inflammation is a condition associated with the inflammation of the blood vessel caused by the overexpression of pro-inflammatory cytokines involved in vascular inflammation. Atherosclerosis is characterized by chronic inflammation of the vascular wall.

Chronic vascular inflammation has been found to cause historical changes in the blood vessel walls, leading to blood vessel wall thickening, weakening, narrowing or scarring on orchestrating blood flow restriction,  resulting in organ and tissue damage.

Most common symptoms of vascular inflammation are associated with the reduced blood flow to supply nutrients and fluid to the body tissues, including fever, headache, fatigue, general aches, and pains, night sweats, rash,  numbness, and weakness.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On findings, a potential compound for the treatment of acute vascular inflammation researchers evaluated the anti-inflammatory activity, the cytotoxic effect of a novel chemically modified, non-carbonyl compound enriched Curcuma longa L. (C. longa) extract (CMCE).

According to the tested analysis, CMCE at the concentration of 1 or 10 μg/mL at 14 h, significantly decreased LPS (50-100 ng/mL) induced production of pro-inflammatory cytokines including TLR4 expression in THP-1 cells, human, and mouse whole blood.

In THP-1 cells, CMCE inhibited the expression of IRAK1, which plays a critical role in initiating an innate immune response against foreign pathogens, MAPK involved in directing cellular responses to a diverse array of stimuli.

CMCE (30, 100, and 300 mg/kg; 10 days p.o.) pre-treated and LPS (10 mg/kg) in Swiss mice exhibited attenuated plasma TNF-α, IL-1β, nitrite, aortic iNOS expression, and vascular dysfunction associated with the production of pro-inflammatory cytokines.

In HL-60 cells., CMCE. exerted cytotoxic effects through cell cycle arrest on the Sub-G1 phase, increased apoptotic cells, loss of mitochondrial membrane in the cancer cells and activation of cascade associated with pro-apoptosis.

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of vascular inflammation, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A Standardized Chemically Modified Curcuma longa Extract Modulates IRAK-MAPK Signaling in Inflammation and Potentiates Cytotoxicity by Rana M1, Maurya P1, Reddy SS1, Singh V1, Ahmad H2, Dwivedi AK2, Dikshit M1, Barthwal MK. (PubMed)
(2) Curcumin: An Effective Inhibitor of Interleukin-6 by Ghandadi M1, Sahebkar A. (PubMed)