Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Wednesday, 17 July 2019

Phytochemical Betacyanins Might Reduce Risk of Insulin Resistance

By Kyle J. Norton

A group of scientists might have found a solution to fix the insulin resistance associated with metabolic factors, according to the Fuli Institute of Food Science.

Or, at least they said their finding appears to block the insulin resistance in high-fat-diet (HFD)-induced obese mice by the analysis of purified pitaya peel betacyanins (PPBNs) activity.

Insulin resistance is a condition in which the body has failed to use insulin property in converting glucose to energy in the muscles, body fat, intestine, and liver. The condition is a hallmark of type 2 diabetes.

Believe it or not, over 100 million Americans are living with insulin resistance. Approximately 1 in 3, including half of those age 60 and older have a silent blood sugar problem known as insulin resistance.

Insulin resistance is not caused by a single factor, epidemiologically, aging, ethnicity, overweight or obese, too much belly fat, physical inactivity, smoking and certain medical conditions such as Cushing’s disease or polycystic ovary disease are some of the prevalent factors that induce the risk of the syndrome.

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belongings to the group of Betalains, found abundantly in beets, chard, etc.

According to the results of male C57BL/6 mice fed a low-fat diet, HFD or HFD supplemented with the purified pitaya peel betacyanins (PPBNs) for 14 weeks, all betacyanin concentrations found in the PPBNs reduced HFD-induced parameters associated with metabolic disorder including insulin resistance, thus reducing symptoms of tiredness, hunger, and difficulty concentration.

Moreover, genes associated with the induction of obesity-induced insulin resistance in obese mice were significantly decreased by the administration of PPBNs.

In fact, insulin resistance over time associated with a genetic preposition can reduce the function of the beta cells in the pancreas, leading to the onset of prediabetes and diabetes.

As of today, there is a no effective treatment for insulin resistance, some researchers suggested by a change of diets such as low-carbohydrate and ketogenic diets or very-low-calorie diet and regular physical activity patients to prevent the risk of obesity may reduce the effects of insulin resistance.

Dr. Stephen R Bird, the lead scientist wrote, "combining exercise interventions with dietary and feeding manipulations to investigate the potential for augmenting the exercise-induced improvements in SI and glycaemic control".

The purified pitaya peel betacyanins also increased the expression of lipid metabolism involved in obese mice.

Taken altogether, betacyanins may be considered a remedy for the prevention and treatment of insulin resistance, pending to the confirmation of larger sample size and multicenter human study.

Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Red pitaya betacyanins protects from diet-induced obesity, liver steatosis and insulin resistance in association with modulation of gut microbiota in mice by Song H1,2, Chu Q1, Yan F1, Yang Y1, Han W1, Zheng X. (PubMed)
(2) Purified Betacyanins from Hylocereus undatus Peel Ameliorate Obesity and Insulin Resistance in High-Fat-Diet-Fed Mice by Song H1, Chu Q1, Xu D1, Xu Y1, Zheng X. (PubMed)
(3) Update on the effects of physical activity on insulin sensitivity in humans by Stephen R Bird1 and John A Hawley. (PMC)

Healthy Food Cucumber, the Best Antioxidant Functional Food

By Kyle J. Norton

Antioxidants are stable molecules that inhibit oxidation produced either by the liver or from the consumption of antioxidant-rich foods.

In other words, antioxidants inhibit the unstable free radicals with a single electron in the outermost ring that facilitates the domino's reaction to cause oxidative stress.

Free radicals are unstable molecules existing everywhere in the environment and in the body. The air we breathe and the food we eat and cellular metabolism are found to induce the production of free radicals.

Free radicals in moderate are necessary for the proper function of our body, such as free radical NO which is needed to relax the blood vessels. However, overexpression of free radicals can induce oxidative stress in the tissues and organs, leading protein, lipid, and cellular DNA damage.

Overexpression of oxidative stress over time has linked to the onset of chronic diseases, inclduing arthritis, cardiovascular disease, diabetes, and cancer.

In a healthy individual, antioxidant enzymes produced by the body are good enough to neutralize the levels of free radicals in the body. However, people with a weakened immune system may need an additional dietary source of antioxidant.

Most common risk factors associated with oxidative stress are antioxidants deficiency in the body caused by demographic, physical, lifestyle or nutritional factors.

Some researchers suggested people who smoke may be at the increased risk of oxidative stress.

Dr. the lead scientist wrote, "Cigarette smoking is a major risk factor for several human diseases. Chronic inflammation, resulting from increased oxidative stress, has been suggested as a mechanism that contributes to the increased susceptibility of smokers to cancer and microbial infections".

And, "Several studies have indicated greater levels of oxidative stress in cigarette smokers [31, 32], which is most likely attributed to the high concentration of ROS and nitrogen species (RNS) in cigarette smoke [33–36]. In addition, cigarette smoke has been associated with elevated ROS production by leukocytes in the airways of both acute and chronic smokers [37]".

The results strongly suggested, if you smoke, your risk of diseases associated with oxidative stress increased substantially, compared to those who don't.

The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural compound which processes antioxidative stress, researchers examined the antioxidant activity of polysaccharide from cucumber (Cucumis saticus L.) prepared by the hydrothermal method.

According to the tested assays in the chemical analysis of body fluids, the trichloroacetic acid (TCA) method showed had a higher deproteinization percentage compared to other hydrothermal preparation.

In other words, the trichloroacetic acid (TCA) method demonstrated a little higher polysaccharide loss percentage due to the effect of the cucumber polysaccharide linkage by the β-glycosidic bonds.

According to the chemical constituent analysis, d-glucose, d-mannose, d-galactose, l-rhamnose, d-xylose, l-arabinose, d-glucuronic acid, and d-galacturonic acid worked synergistically in exerting scavenging ability against free radical superoxide anions.

Taken altogether, cucumber may be the beast antioxidant whole food for the treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Preparation, deproteinization, characterisation, and antioxidant activity of polysaccharide from cucumber (Cucumis saticus L.) by Chen L1, Huang G2, Hu J. (PubMed)
(2) Effects of Heat Shock on Photosynthetic Properties, Antioxidant Enzyme Activity, and Downy Mildew of Cucumber (Cucumis sativus L.) by Ding X1,2, Jiang Y1, Hao T1, Jin H1, Zhang H1, He L1, Zhou Q1, Huang D2, Hui D3, Yu J. (PubMed)
(3) Role of Oxidative Stress in the Suppression of Immune Responses in Peripheral Blood Mononuclear Cells Exposed to Combustible Tobacco Product Preparation by Subhashini Arimilli,

1 Eckhardt Schmidt,2 Brad E. Damratoski,3 and G. L. Prasad. (PMC)

Lycopene Isolated from Tomatoes, the Natural Remedy in the Promotion of Insulin Sensitivity

By Kyle J. Norton

Insulin sensitivity is a term to measure how sensitive the body's cells are in response to insulin.

Low insulin sensitivity, also known as insulin resistance induces high levels of glucose in the blood. Over the long term insulin resistance ultimately can lead type II diabetes.

Insulin resistance is considered a hallmark of type II diabetes and a condition in the cluster of metabolic syndrome.

There is no single cause of insulin resistance. Medical conditions, being extreme overweight, ethnicity, genetic proposition, and physical inactivity are some of the prevalent risks of insulin resistance.

Some researchers suggested the widespread obesity over the past few decades in the induction of insulin resistance at the alarming rate may be correlated to the promotion of a high-fat diet in the Western world.

Dr. von Frankenberg AD, the lead scientist wrote, "The rate of glucose disposal (Rd) during low- and high-dose insulin decreased on the HFD but remained unchanged on the LFD" and "Changes in subcutaneous fat were positively associated with changes in insulin sensitivity on the LFD (r = 0.78, p < 0.01) with a trend on the HFD".

And, "A diet very high in fat and saturated fat adversely affects insulin sensitivity and thereby might contribute to the development of type 2 diabetes".

In other words, if you are high-fat diet follower, you are at substantial risk to develop insulin resistance.

Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

With an aim to find a potential compound or whole food for the improvement of insulin sensitivity, researchers examined lycopene, one of the major carotenoids in tomatoes, and other whole food in high-fat diet (HFD)-animal model.

Mice selected to the study were fed with different doses of dry tomato peel (DTP) in a high-saturated-fat (HSF) diet and cholesterol-rich diet-induced oxidative stress for the 12-weeks.

Lycopene significantly prevented HFD-induced increase of fasting blood glucose and insulin level and insulin intolerance and a decrease of hepatic glycogen content associated with the production of hepatic insulin.

Furthermore, increased levels of pro-inflammatory cytokines and CRP levels in mice fed HFD involved in the risk of insulin intolerance were also reduced significantly by the presence of lycopene

Moreover, lycopene was also found to suppress the increase of the expression of proteins Srebp-1c, that regulate the glucose and the cluster of conditions of metabolic syndrome in mice fed HFD.

Interestingly, lycopene promoted insulin sensitivity by inducing the STAT3 signaling in reducing fasting blood glucose and insulin level.

In other words, lycopene exerted a strong insulin sensitivity by inhibiting inflammation, insulin resistance, and metabolic dysfunction.

In order to reveal more information about the tomato in the promotion of insulin sensitivity, researchers investigated the effects of different doses of dry tomato peel (DTP) on the levels of oxidative stress in mice fed an HSF and cholesterol-rich diet for 12 weeks.

The study included BALB/c male mice (n=40) (8 weeks old, weighing 22.2±1.0 g) divided into four treatment groups (10 mice/group): (a) high-fat control diet (HF Ctrl), which contains sunflower oil as a sole source of fat; (b) HSF/high-cholesterol (HC) diet; (c) HSF/HC diet supplemented with 9% DTP and (d) HSF/HC diet supplemented with 17% DTP.

According to the observation of the tested assays, HSF/HC diet mice significantly increased adipose tissue weight, fasting plasma glucose, fasting plasma insulin, and lipid peroxidation.

Administration of lycopene DTP increased plasma lycopene concentration and reduced the development of indicators of metabolic syndrome, with no consistent effect of the DTP dose.

Dr. Zidani S, the lead scientists after taking into account co and confounders said, "Among mice fed the HSF/HC diet, DTP supplementation appears to have a beneficial effect on insulin resistance, which confirms the antiatherogenic effect of DTP".

Taken altogether, tomatoes processed high amounts of bioactive compound lycopene may be considered supplements for the prevention and treatment of insulin intolerance, pending to the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Lycopene Improves Insulin Sensitivity through Inhibition of STAT3/Srebp-1c-Mediated Lipid Accumulation and Inflammation in Mice fed a High-Fat Diet by Zeng Z1, He W2, Jia Z2, Hao S. (PubMed)
(2) Effect of dry tomato peel supplementation on glucose tolerance, insulin resistance, and hepatic markers in mice fed high-saturated-fat/high-cholesterol diets by Zidani S1, Benakmoum A2, Ammouche A3, Benali Y4, Bouhadef A4, Abbeddou S. (PubMed)
(3) A high-fat, high-saturated fat diet decreases insulin sensitivity without changing intra-abdominal fat in weight-stable overweight and obese adults by von Frankenberg AD1,2,3, Marina A4, Song X5,6, Callahan HS7, Kratz M4,5,6, Utzschneider KM. (PubMed)

Bromelain Inhibits the Risk of Skin Cancer In Vitro

By Kyle J. Norton

Skin cancer is a medical condition caused by irregular cell growth in the skin tissues, due to the alternation of cell DNA.

Most cases of skin cancer in the US are associated with prolong-period of sun exposure. In other words, UV rays that damage the skin have been the main culprit that causes the onset of skin cancer.

Believe it or not, according to the statistics, skin cancer is the most common cancer in the US. one in five Americans will develop skin cancer in their lifetime.

Every day, approximately 9,500 people in the U.S. are diagnosed with skin cancer due to a misunderstanding of the health benefits and risk of sun and tanning exposure.

Most common symptoms at the early stage, are a large brownish spot with darker speckles, a mole that changes in color, size or feel or that bleeds, a small lesion with an irregular border and portions that appear red, pink, white, blue or blue-black.

There are 3 major types of skin cancer, including

* Basal cell cancer
It is the most common type of skin cancer associated with the abnormal growth of the cells in the lowest layer of the epidermis. Cancer rarely spread and kill but can cause significant destruction and disfigurement to the affected skin area, accounting for more than 90% of all skin cancer in the U.S.

* Squamous cell cancer
It arises from the uncontrolled multiplication of transformed malignant cells in the middle layer of the epidermis.

* Melanoma
Melanoma is less common compared to other skin cancer caused by the malignancy of melanocytes, the cell produced dark pigment for your skin.

Some researchers suggested that by seeking the shade, especially between 10 AM and 4 PM. covering yourself with proper sunglasses, clothing, and hat, using sun protective cream, particularly in avoidance of tanning and UV tanning beds, most types of skin cancer are preventable

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

In the urgency to find a natural ingredient for the treatment of skin cancer, researchers examined the bromelain (BL) effect in the form of nanoparticles (NPs) based delivery systems on skin cancer cells.

The formulated NPs with a mean particle size of 130.4 ± 8.81 nm exhibited sustained release of BL by observation of the analysis.

According to the tested assays, BL loaded poly (lactic-co-glycolic acid) NPs enhanced anti-tumor effects compared to free BL.

In tumorigenesis mice model, NPs reduced the average number of tumors by 2.3 folds), delayed tumorigenesis by 2 weeks), and inhibited the percent tumorigenesis by 4 folds.

Furthermore, administration of NPs also exerted a significant effect on reduced the percent mortality rate and the average tumor volume.

More precisely, NPs demonstrated anti-cancer cell efficacy was attributed to its capability in modulating the expression of pro-apoptotic (P53, Bax) and anti-apoptotic (Bcl2) proteins.

Based on the finding, researchers said, "developed NPs formulation could be used to improve the efficacy of chemotherapy by exerting chemo-preventive effects against induced carcinogenesis at lower dosages".

Additionally, in another mouse skin tumorigenesis model, bromelain not only exerted a similar effect of the aforementioned study it also reduced tumor volume up to a tune of approximately 65%.

In this case, bromelain induced cancer cells apoptosis by stimulating the expression of proteins associated with tumor-suppressive and pro-apoptotic genes, inhibiting the gene involved in anti-apoptosis.

Taken altogether, bromelain may be considered supplements for the prevention and treatment of skin cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources

(1) Bromelain nanoparticles protect against 7,12-dimethylbenz[a]anthracene induced skin carcinogenesis in mouse model by Bhatnagar P1, Pant AB2, Shukla Y2, Chaudhari B2, Kumar P1, Gupta KC. (PubMed)
(2) Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway by Bhui K1, Prasad S, George J, Shukla Y. (PubMed)

Tuesday, 16 July 2019

Phytochemical Alliin Processes the Immunomodulatory Effect

By Kyle J. Norton

The immunomodulatory effect is an action in which the immune function is modulated to the needs of the body.

The immune system included the thymus and bone marrow, as well as secondary lymphatic tissues including spleen, tonsils, lymph vessels, lymph nodes, adenoids, skin, and liver, is the body's defense against infectious organisms and foreign invaders.

In the acute phase of infection, the immune macrophages, the first line of defense stimulates the production of blood palette to cover the wound or injury and pro-inflammatory cytokines to the site of infection to kill off pathogens before they can enter the body to multiply.

Most cases of infection are stopped at the acute phase, depending on the size and penetration of the wound.

However, if the immune system for whatever reason such as in people with a weakened immune system can not destroy the foreign invaders in the set period of time (3-8 weeks), it will adapt to the new change, leading to chronic low-grade inflammation.

Low-grade inflammation over time has been found to destroy cells and tissues in the affected area or organ, inducing chronic inflammatory disease, including diabetes, arthritis, and cardiovascular disease.

Out of many low-grade inflammatory risk factors, some researchers suggested that an unhealthy diet may be one of the major culprits involved in facilitating the onset of the diseases.

Dr. Casas R, Sacanella E, the lead scientist wrote, "Dietary patterns high in refined starches, sugar, and saturated and trans-fatty acids, poor in natural antioxidants and fiber from fruits, vegetables, and whole grains, and poor in omega-3 fatty acids may cause an activation of the innate immune system, most likely by excessive production of proinflammatory cytokines associated with a reduced production of anti-inflammatory cytokines".

In other words, if you follow the diet pattern of a high-fat diet, you are at a higher risk of low-grade inflammatory disease, compared to those who follow the diet pattern of the Mediterranean diet.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belongings to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find a natural ingredient with immunomodulatory activity, researchers examined the effect of the garlic derivative alliin, on the mitogen-induced peripheral blood mononuclear cell (PBMC) proliferation and cytokine production in vitro.

Before treated with garlic derivative alliin, pokeweed mitogen (PWM) injection induced cell proliferation, production of proinflammatory cytokines, including IL-1beta and TNF-alpha.

Furthermore, pokeweed mitogen (PWM) treated group also showed reduced levels of both percentage of phagocyting cells and number of latex particles associated with the immune functions of phagocytosis.

Administration of garlic derivative alliin not only decreased the production of proinflammatory cytokines induced by pokeweed mitogen (PWM) but also improved the levels of antioxidant enzymes.

In other words, alliin exerted an immunomodulatory effect on the peripheral blood cells in vitro.

In order to reveal more information of alliin effect on the immune system, researchers investigated whether different plant-derived components with similar anti-oxidative and anti-inflammatory function such as quercetin and alliin in traditional Asian diet consumed in an alternate style cooperatively affect health including the growth of host and the status of the gut microbiota and colonic epithelial immunity.

Compared to the traditional Asian diet significantly increased the rat body weight and reshaped the gut microbiota composition by significantly increased the relative abundance of fecal Firmicutes and Cyanobacteria but decreased that of Bacteroidetes (P < 0.05) and increased the relative abundance of Candidatus Arthromitus, Lactococcus, Geobacillus, and Ruminococcus at the genus level that benefits the host's health, the consumption of quercetin and alliin also altered 13 genes expression involved in the KEGG pathways of complement and coagulation cascades and hematopoietic cell lineage to improve the gut immunity.

In other words, the alternate consumption of quercetin and alliin can contribute beneficial metabolic effects by optimizing gut microbiota and altering the immunologic function of colonic epithelial cells.

Taken altogether, alliin may be considered supplements for the immune modulatory activity depending on the body needs, pending to the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of a garlic derivative (alliin) on peripheral blood cell immune responses by Salman H1, Bergman M, Bessler H, Punsky I, Djaldetti M. (PubMed)
(2) The Alternate Consumption of Quercetin and Alliin in the Traditional Asian Diet Reshaped Microbiota and Altered Gene Expression of Colonic Epithelial Cells in Rats by Yu J1, Guo H1, Xie J1, Luo J1, Li Y1, Liu L1, Ou S1, Zhang G1, Peng X. (PubMed)
(3) The immune protective effect of the Mediterranean diet against chronic low-grade inflammatory diseases by Casas R, Sacanella E, Estruch R. (PubMed)

Herbal Ginger, the Best for the Prevention and Treatment of Hypothermia

By Kyle J. Norton

Hypothermia is a medical condition caused by the loss of heat faster than it can produce heat by the body.

In other words, hypothermia occurs if the body temperature is falling below 95 F (35 C) compared to the normal body temperature of 98.6 F (37 C).

Most cases of hypothermia is a medical emergency as the falling body temperature can lead reduce the function of the heart, nervous system and other organs.

Exposure to cold weather without proper clothing and homeless people in the cold Winter day are the most common cause of hypothermia in Canada.

According to the statistics from the US government, approximately 67% of hypothermia-related deaths were among males. Between 1999 to 2011, there is a total of 16,911 deaths with an average of 1,301 per year associated with exposure to excessive natural cold.

Symptoms of hypothermia are shaking slightly and uncontrollably, lack of coordination, sleepiness, confuse, particularly bright red skin. If you see someone in this condition in the very cold day, please call 911, as this person does not know that he/she has hypothermia.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find a natural compound or whole food for the treatment of hypothermia, researchers examined the anti-hypothermic action of ginger extract (GE) by employing a solid dispersion (SD) (GE/SD) prepared in terms of physicochemical and pharmacokinetic properties.

GE/SD improved dissolution behavior of the major active ingredients in GE for the treatment of the condition.

In other words, GE/SD enhanced the properties of 6-gingerol (6G) and 8-gingerol (8G), against hypothermia with levels of dissolution 12- and 31-fold higher than that of GE, respectively.

However, 6G and 8G were slightly degraded in compared to the GE.

Oral administration of GE (300 mg/kg) and GE/SD (100 mg of GE/kg), the relative bioavailabilities of 6G and 8G in GE/SD were 5.0- and 5.8-fold higher than those in GE, respectively.

The efficacy of GE/SD (30 mg of GE/kg) inhibited ethanol-evoked hypothermia was attributed to the improved oral absorption of 6G and 8G.

Furthermore, in order to reveal more information about GE activity in removing chills caused by common cold and to warm body, researchers the anti hypothermic effect of acetone extract of ginger at 100 mg/kg p.o.

Oral administration of acetone extract of ginger at 100 mg/kg p.o. significantly inhibited serotonin (5-HT) induced hypothermia in tested subjects.

Additional differentiation suggested that [6]-shogaol obtained from fraction 2-2, at 10 mg/kg p.o.was found to potentiate the effect of the acetone extract against the onset of hypothermia.

Take all together, ginger may be considered a functional alternative for the prevention and treatment of hypothermia with no side effects, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Ginger Extract-Loaded Solid Dispersion System with Enhanced Oral Absorption and Antihypothermic Action by Sato H1, Ogino M1, Yakushiji K1, Suzuki H1, Shiokawa KI2, Kikuchi H2, Seto Y1, Onoue S1. (PubMed)
(2) [The effect of ginger on serotonin induced hypothermia and diarrhea].[Article in Japanese] by Huang Q1, Matsuda H, Sakai K, Yamahara J, Tamai Y. (PubMed)

Herbal Artichoke, The Potent Anti Liver Cancer Natural Remedy

By Kyle J. Norton

Artichoke may have potential and positive effects in protecting the liver against the onset of liver diseases, according to studies.

The liver is the large organ in the human body processed a significant activity on filtering the blood coming from the digestive tract, before passing it to the rest of the body.

Furthermore, the function of the liver also includes removing and breaking down most drugs and chemicals from your bloodstream and toxins created byproducts that can damage the liver and the body.

However, long-term and persistent exposure to toxic substances can cause serious damage, sometimes irreversible harm to the liver.

Liver cancer is a medical condition characterized by irregular cell growth due to the alternation of liver cell DNA.

Most common metastasis of primary liver cancer is breast, colorectal cancer, and esophageal cancer.

Most cases of primary liver cancer start in the cells on the surface of the inner lining of the liver tissues. Due to the small size of the tumor at the early stage, most patients with liver cancer do not experience any symptoms.

Genetic preposition, hepatitis viral infection, alcohol abuse, and cirrhosis are the common risk factor associated with the onset of liver cancer.

According to the statistics, 43% of people who are diagnosed at an early stage have a 5-year survival rate of 31% compared to that of 3 to 5% at the advanced stage.

In the Western world, more than half of all people diagnosed with primary liver cancer have cirrhosis, a scarring condition of the liver commonly caused by alcohol abuse.

Dr.Elliot B Tapper, in the investigation of the alcoholic risk of liver cancer mortality in the US, said, "Mortality due to cirrhosis has been increasing in the US since 2009. Driven by deaths due to alcoholic cirrhosis, people aged 25-34 have experienced the greatest relative increase in mortality. White Americans, Native Americans, and Hispanic Americans experienced the greatest increase in deaths from cirrhosis".

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.

Researchers on finding a natural compound for the treatment of liver cancer with no side effects evaluated the effect of fish oil and Artichoke (Cynara scolymus I.) against diethylnitrosamine (DEN) induced hepatocellular carcinoma in rats.

Rats selected into the study were divided into 8 groups. Group 1, control rats. Group 2: rats injected with a single dose of DEN (100 mg/kg body weight). Groups 3-8 supplemented with different concentrations of either fish oil or artichoke for 25 days before DEN injection.

DEN injected group not only showed a significant decrease levels fo antioxidant enzymes produced by the host but also exhibited the overexpression of free radical formation and oxidative stress marker.

Furthermore, Den injected group also showed the increased inflammatory cytokines and stimulated protein associated forming new blood vessels for cancer growth accompanied by liver damage through the expression of liver function markers.

Moreover, the administration of DEN also affected the liver cell through the occurrence of hepatic cellular degeneration and necrosis.

Treatment with fish oil (5%, 10%) or artichoke heads or leaves (0.5, 1 g) for 25 days displayed a significant amelioration of DEN-induced changes in the biochemical parameters.

In the depth analysis, the administration of fish oil (5%, 10%) or artichoke heads or leaves (0.5, 1 g) fish oil (5%, 10%) or artichoke heads or leaves (0.5, 1 g) almost restored the liver functioning in treated groups, compared to the controls.

Dr. Metwally NS and colleagues in the final report wrote, "The results pointed out that 10% fish oil and 1 g% leaves of artichoke succeeded to protect from hepatocellular carcinoma to a certain degree. In addition, they may be considered as protective foods against angiogenesis".

In order to reveal more information about the artichoke anti-liver cancer activity, researchers examined the polyphenolic extracts from an edible part of artichoke (Cynara scolymus L.) on cultured rat hepatocytes and on human hepatoma cells.

On hepatocytes exposed to H2O2generated in situ by glucose oxidase, injection of AE not only restored the levels of antioxidant enzymes from the host but also decreased the oxidative stress marker in the liver.

In other words, AE protected the liver against lipid peroxidation and cell death and prevented the loss of total GSH and the accumulation of MDA.

Additionally, AE also reduced cell viability in a dose-dependent manner in HepG2 cells in 24 h.

In liver cancer cell lines, AE induced liver protective activity by activating the proteins associated with cell apoptosis, according to the flow cytometric analysis of annexin.

Dr. Miccadei S, the lead scientist said, "AE had a marked antioxidative potential that protects hepatocytes from oxidative stress. Furthermore, AE reduced cell viability and had an apoptotic activity on a human liver cancer cell line".

Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of liver cancer, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(2) The protective effects of fish oil and artichoke on hepatocellular carcinoma in rats by Metwally NS1, Kholeif TE, Ghanem KZ, Farrag AR, Ammar NM, Abdel-Hamid AH. (PubMed)
(2) Antioxidative and apoptotic properties of polyphenolic extracts from edible part of artichoke (Cynara scolymus L.) on cultured rat hepatocytes and on human hepatoma cells by Miccadei S1, Di Venere D, Cardinali A, Romano F, Durazzo A, Foddai MS, Fraioli R, Mobarhan S, Maiani G. (PubMed)
(3) Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study by Elliot B Tapper, and Neehar D Parikh. (the BMJ)