Phytochemical Alliin Processes the Immunomodulatory Effect

By Kyle J. Norton

The immunomodulatory effect is an action in which the immune function is modulated to the needs of the body.

The immune system included the thymus and bone marrow, as well as secondary lymphatic tissues including spleen, tonsils, lymph vessels, lymph nodes, adenoids, skin, and liver, is the body's defense against infectious organisms and foreign invaders.

In the acute phase of infection, the immune macrophages, the first line of defense stimulates the production of blood palette to cover the wound or injury and pro-inflammatory cytokines to the site of infection to kill off pathogens before they can enter the body to multiply.

Most cases of infection are stopped at the acute phase, depending on the size and penetration of the wound.

However, if the immune system for whatever reason such as in people with a weakened immune system can not destroy the foreign invaders in the set period of time (3-8 weeks), it will adapt to the new change, leading to chronic low-grade inflammation.

Low-grade inflammation over time has been found to destroy cells and tissues in the affected area or organ, inducing chronic inflammatory disease, including diabetes, arthritis, and cardiovascular disease.

Out of many low-grade inflammatory risk factors, some researchers suggested that an unhealthy diet may be one of the major culprits involved in facilitating the onset of the diseases.

Dr. Casas R, Sacanella E, the lead scientist wrote, "Dietary patterns high in refined starches, sugar, and saturated and trans-fatty acids, poor in natural antioxidants and fiber from fruits, vegetables, and whole grains, and poor in omega-3 fatty acids may cause an activation of the innate immune system, most likely by excessive production of proinflammatory cytokines associated with a reduced production of anti-inflammatory cytokines".

In other words, if you follow the diet pattern of a high-fat diet, you are at a higher risk of low-grade inflammatory disease, compared to those who follow the diet pattern of the Mediterranean diet.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belongings to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find a natural ingredient with immunomodulatory activity, researchers examined the effect of the garlic derivative alliin, on the mitogen-induced peripheral blood mononuclear cell (PBMC) proliferation and cytokine production in vitro.

Before treated with garlic derivative alliin, pokeweed mitogen (PWM) injection induced cell proliferation, production of proinflammatory cytokines, including IL-1beta and TNF-alpha.

Furthermore, pokeweed mitogen (PWM) treated group also showed reduced levels of both percentage of phagocyting cells and number of latex particles associated with the immune functions of phagocytosis.

Administration of garlic derivative alliin not only decreased the production of proinflammatory cytokines induced by pokeweed mitogen (PWM) but also improved the levels of antioxidant enzymes.

In other words, alliin exerted an immunomodulatory effect on the peripheral blood cells in vitro.

In order to reveal more information of alliin effect on the immune system, researchers investigated whether different plant-derived components with similar anti-oxidative and anti-inflammatory function such as quercetin and alliin in traditional Asian diet consumed in an alternate style cooperatively affect health including the growth of host and the status of the gut microbiota and colonic epithelial immunity.

Compared to the traditional Asian diet significantly increased the rat body weight and reshaped the gut microbiota composition by significantly increased the relative abundance of fecal Firmicutes and Cyanobacteria but decreased that of Bacteroidetes (P < 0.05) and increased the relative abundance of Candidatus Arthromitus, Lactococcus, Geobacillus, and Ruminococcus at the genus level that benefits the host's health, the consumption of quercetin and alliin also altered 13 genes expression involved in the KEGG pathways of complement and coagulation cascades and hematopoietic cell lineage to improve the gut immunity.

In other words, the alternate consumption of quercetin and alliin can contribute beneficial metabolic effects by optimizing gut microbiota and altering the immunologic function of colonic epithelial cells.

Taken altogether, alliin may be considered supplements for the immune modulatory activity depending on the body needs, pending to the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of a garlic derivative (alliin) on peripheral blood cell immune responses by Salman H1, Bergman M, Bessler H, Punsky I, Djaldetti M. (PubMed)
(2) The Alternate Consumption of Quercetin and Alliin in the Traditional Asian Diet Reshaped Microbiota and Altered Gene Expression of Colonic Epithelial Cells in Rats by Yu J1, Guo H1, Xie J1, Luo J1, Li Y1, Liu L1, Ou S1, Zhang G1, Peng X. (PubMed)
(3) The immune protective effect of the Mediterranean diet against chronic low-grade inflammatory diseases by Casas R, Sacanella E, Estruch R. (PubMed)

Herbal Ginger, the Best for the Prevention and Treatment of Hypothermia

By Kyle J. Norton


Hypothermia is a medical condition caused by the loss of heat faster than it can produce heat by the body.

In other words, hypothermia occurs if the body temperature is falling below 95 F (35 C) compared to the normal body temperature of 98.6 F (37 C).

Most cases of hypothermia is a medical emergency as the falling body temperature can lead reduce the function of the heart, nervous system and other organs.

Exposure to cold weather without proper clothing and homeless people in the cold Winter day are the most common cause of hypothermia in Canada.

According to the statistics from the US government, approximately 67% of hypothermia-related deaths were among males. Between 1999 to 2011, there is a total of 16,911 deaths with an average of 1,301 per year associated with exposure to excessive natural cold.

Symptoms of hypothermia are shaking slightly and uncontrollably, lack of coordination, sleepiness, confuse, particularly bright red skin. If you see someone in this condition in the very cold day, please call 911, as this person does not know that he/she has hypothermia.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find a natural compound or whole food for the treatment of hypothermia, researchers examined the anti-hypothermic action of ginger extract (GE) by employing a solid dispersion (SD) (GE/SD) prepared in terms of physicochemical and pharmacokinetic properties.

GE/SD improved dissolution behavior of the major active ingredients in GE for the treatment of the condition.

In other words, GE/SD enhanced the properties of 6-gingerol (6G) and 8-gingerol (8G), against hypothermia with levels of dissolution 12- and 31-fold higher than that of GE, respectively.

However, 6G and 8G were slightly degraded in compared to the GE.

Oral administration of GE (300 mg/kg) and GE/SD (100 mg of GE/kg), the relative bioavailabilities of 6G and 8G in GE/SD were 5.0- and 5.8-fold higher than those in GE, respectively.

The efficacy of GE/SD (30 mg of GE/kg) inhibited ethanol-evoked hypothermia was attributed to the improved oral absorption of 6G and 8G.

Furthermore, in order to reveal more information about GE activity in removing chills caused by common cold and to warm body, researchers the anti hypothermic effect of acetone extract of ginger at 100 mg/kg p.o.

Oral administration of acetone extract of ginger at 100 mg/kg p.o. significantly inhibited serotonin (5-HT) induced hypothermia in tested subjects.

Additional differentiation suggested that [6]-shogaol obtained from fraction 2-2, at 10 mg/kg p.o.was found to potentiate the effect of the acetone extract against the onset of hypothermia.

Take all together, ginger may be considered a functional alternative for the prevention and treatment of hypothermia with no side effects, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Ginger Extract-Loaded Solid Dispersion System with Enhanced Oral Absorption and Antihypothermic Action by Sato H1, Ogino M1, Yakushiji K1, Suzuki H1, Shiokawa KI2, Kikuchi H2, Seto Y1, Onoue S1. (PubMed)
(2) [The effect of ginger on serotonin induced hypothermia and diarrhea].[Article in Japanese] by Huang Q1, Matsuda H, Sakai K, Yamahara J, Tamai Y. (PubMed)

Herbal Artichoke, The Potent Anti Liver Cancer Natural Remedy

By Kyle J. Norton

Artichoke may have potential and positive effects in protecting the liver against the onset of liver diseases, according to studies.

The liver is the large organ in the human body processed a significant activity on filtering the blood coming from the digestive tract, before passing it to the rest of the body.

Furthermore, the function of the liver also includes removing and breaking down most drugs and chemicals from your bloodstream and toxins created byproducts that can damage the liver and the body.

However, long-term and persistent exposure to toxic substances can cause serious damage, sometimes irreversible harm to the liver.

Liver cancer is a medical condition characterized by irregular cell growth due to the alternation of liver cell DNA.

Most common metastasis of primary liver cancer is breast, colorectal cancer, and esophageal cancer.

Most cases of primary liver cancer start in the cells on the surface of the inner lining of the liver tissues. Due to the small size of the tumor at the early stage, most patients with liver cancer do not experience any symptoms.

Genetic preposition, hepatitis viral infection, alcohol abuse, and cirrhosis are the common risk factor associated with the onset of liver cancer.

According to the statistics, 43% of people who are diagnosed at an early stage have a 5-year survival rate of 31% compared to that of 3 to 5% at the advanced stage.

In the Western world, more than half of all people diagnosed with primary liver cancer have cirrhosis, a scarring condition of the liver commonly caused by alcohol abuse.

Dr.Elliot B Tapper, in the investigation of the alcoholic risk of liver cancer mortality in the US, said, "Mortality due to cirrhosis has been increasing in the US since 2009. Driven by deaths due to alcoholic cirrhosis, people aged 25-34 have experienced the greatest relative increase in mortality. White Americans, Native Americans, and Hispanic Americans experienced the greatest increase in deaths from cirrhosis".

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.

Researchers on finding a natural compound for the treatment of liver cancer with no side effects evaluated the effect of fish oil and Artichoke (Cynara scolymus I.) against diethylnitrosamine (DEN) induced hepatocellular carcinoma in rats.

Rats selected into the study were divided into 8 groups. Group 1, control rats. Group 2: rats injected with a single dose of DEN (100 mg/kg body weight). Groups 3-8 supplemented with different concentrations of either fish oil or artichoke for 25 days before DEN injection.

DEN injected group not only showed a significant decrease levels fo antioxidant enzymes produced by the host but also exhibited the overexpression of free radical formation and oxidative stress marker.

Furthermore, Den injected group also showed the increased inflammatory cytokines and stimulated protein associated forming new blood vessels for cancer growth accompanied by liver damage through the expression of liver function markers.

Moreover, the administration of DEN also affected the liver cell through the occurrence of hepatic cellular degeneration and necrosis.

Treatment with fish oil (5%, 10%) or artichoke heads or leaves (0.5, 1 g) for 25 days displayed a significant amelioration of DEN-induced changes in the biochemical parameters.

In the depth analysis, the administration of fish oil (5%, 10%) or artichoke heads or leaves (0.5, 1 g) fish oil (5%, 10%) or artichoke heads or leaves (0.5, 1 g) almost restored the liver functioning in treated groups, compared to the controls.

Dr. Metwally NS and colleagues in the final report wrote, "The results pointed out that 10% fish oil and 1 g% leaves of artichoke succeeded to protect from hepatocellular carcinoma to a certain degree. In addition, they may be considered as protective foods against angiogenesis".

In order to reveal more information about the artichoke anti-liver cancer activity, researchers examined the polyphenolic extracts from an edible part of artichoke (Cynara scolymus L.) on cultured rat hepatocytes and on human hepatoma cells.

On hepatocytes exposed to H2O2generated in situ by glucose oxidase, injection of AE not only restored the levels of antioxidant enzymes from the host but also decreased the oxidative stress marker in the liver.

In other words, AE protected the liver against lipid peroxidation and cell death and prevented the loss of total GSH and the accumulation of MDA.

Additionally, AE also reduced cell viability in a dose-dependent manner in HepG2 cells in 24 h.

In liver cancer cell lines, AE induced liver protective activity by activating the proteins associated with cell apoptosis, according to the flow cytometric analysis of annexin. 

Dr. Miccadei S, the lead scientist said, "AE had a marked antioxidative potential that protects hepatocytes from oxidative stress. Furthermore, AE reduced cell viability and had an apoptotic activity on a human liver cancer cell line".

Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of liver cancer, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(2) The protective effects of fish oil and artichoke on hepatocellular carcinoma in rats by Metwally NS1, Kholeif TE, Ghanem KZ, Farrag AR, Ammar NM, Abdel-Hamid AH. (PubMed)
(2) Antioxidative and apoptotic properties of polyphenolic extracts from edible part of artichoke (Cynara scolymus L.) on cultured rat hepatocytes and on human hepatoma cells by Miccadei S1, Di Venere D, Cardinali A, Romano F, Durazzo A, Foddai MS, Fraioli R, Mobarhan S, Maiani G. (PubMed)
(3) Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study by Elliot B Tapper, and Neehar D Parikh. (the BMJ)

Herbal Turmeric Protect Your Skin From the Sun UVB

By Kyle J. Norton

Sun protection is an action, including the use of sun-protective cream to protect skin damage against sun exposure.

UVB sunlight has been known to cause skin damage and cancer.

Long-term exposure to the sun can increase the risk of UV rays penetration through the outer skin layers into the deeper layers, leading to damage of skin cells.

In other words, long-term sun exposure can induce the alternation of skin cells, leading to actinic keratosis and basal cell carcinoma, squamous cell carcinoma, and melanoma skin cancer.

There are many ways that you can protect your skin against sun damage
* Using subscreens that protect your skin against both UVA and UVB rays.

* Staying into the shade more often in the sunny day, particularly in the Summer.

* Wearing a hat to protect your the ears, eyes, forehead, nose, and scalp.

* Putting on a shirt with a light color, that helps to reflect the sunlight.  Long-sleeved shirts, long pants, or long skirts cover the most skin are recommended.

* Wearing a sunglass to protect your eyes.

Genetically, your skin types and natural skin color also have a strong impact on skin damage due to the exposure to the Sun. In fact, people with moderately pigmented and darkly pigmented skin can stand more exposure to UV compared to those with light skin color.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural compound which processes sun protection, researchers examined the effects of 15 Thai plants extracts against UVB DNA damage and cytotoxicity in human keratinocytes, an epidermal cell which produces keratin.

By examining the activity of petroleum ether, dichloromethane, and ethanol extracts prepared from 15 Thai herb species, ethanol extracts and dichloromethane fractions isolated from turmeric were found to have highest total phenolic and flavonoid contents, compared to petroleum ether.

Compared to other tested preparations, dichloromethane extract of turmeric possessed the highest antioxidant activity in the protection against UVB induced skin oxidative stress.

Interestingly, the maximum UV absorptions were found in the ethanol extract of turmeric and in the dichloromethane extract of ginger. 

Additional differentiation of these products, researchers found that the efficacy of ethanol and dichloromethane extracts of turmeric against sun exposure is attributed to their functions in stimulating the synthesis of Thioredoxin 1, an antioxidant protein that could protect human HaCaT keratinocytes from UV-induced DNA damage and cytotoxicity.

In other words, turmeric protects the skin from UVB DNA damage and cytotoxicity in human keratinocytes by enhancing the host antioxidant defense against overexpression of ROS induced by sun exposure.

After taking other factors into account, Dr. Thongrakard V, the lead scientist said, "The present data support the utilization of turmeric and ginger extracts in anti-UV cosmetic pharmaceuticals".

Taken altogether, turmeric processed a high amount of bioactive compound dichloromethane may be considered supplements for the prevention and treatment skin damage caused by sun exposure, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Herbal sun protection agents: Human studies by Rabinovich L1, Kazlouskaya V. (PubMed)
(2) Protection from UVB Toxicity in Human Keratinocytes by Thailand Native Herbs Extracts by Thongrakard V1,2, Ruangrungsi N3, Ekkapongpisit M2, Isidoro C2, Tencomnao T. (PubMed)

Herbal Bilberry Improves the Visual Function in Patients with Normal Tension Glaucoma (NTG)

By Kyle J. Norton


Visual functions refer to how well the eye and visual system function.

The visual system, on the other hand, forms part of the central nervous system with a function that requires for visual perception, including receiving, processing and interpreting visual information before passing them to the brain.

Common visual problems of the eye are refractive errors, including nearsightedness, farsightedness, astigmatism, and presbyopia.

According to the statistic provided by the World Health Organization, globally, approximately 1.3 billion people live with some form of vision impairment. In the distance vision perspective, 188.5 million people have a mild vision impairment, 217 million have moderate to severe vision impairment, and 36 million people are blind.

Visual impairment has been found to affect most people in advanced age. Aging not only affects the normal function of eye tissues decreases but also increased the incidence of ocular pathology.

Dr. Loh KY, the lead scientist said, "The most common causes of age-related visual impairment in the elderly are presbyopia, cataracts, age-related macular degeneration, primary open angle glaucoma, and diabetic retinopathy".

And, "Untreated visual impairment leads to physical handicap, increased incidence of fall, depression, social isolation, and dependency".

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belongings to the family Ericaceae, native to Northern Europe.

The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers on finding a natural ingredient for the treatment of glaucoma compared the effect of GBE and anthocyanins found abundantly in bilberry on visual function in patients with normal tension glaucoma (NTG).

The retrospective analysis was carried out by a chart review of 332 subjects (209 men and 123 women) treated with anthocyanins (n=132), GBE (n=103), or no medication (control, n=97).

The mean of treatment in the follow-up duration, anthocyanin, and GBE treatment duration was similar approximately in the range from 6-59 months.

According to the logarithm of the minimal angle of resolution best-corrected visual acuity (logMAR BCVA), anthocyanin treatment for all eyes improved from 0.16 (±0.34) to 0.11 (±0.18) logMAR units (P=.008), and HVF mean deviation improved from -6.44 (±7.05) to -5.34 (±6.42) (P=.001) compared to GBE treatment, the HVF mean deviation improved from -5.25 (±6.13) to -4.31 (±5.60) (P=.002).

These results suggested both anthocyanins and GBE improve the visual function in some individuals with NTG.

Taken altogether, bilberry processed abundantly bioactive compound anthocyanoside may be considered a functioning remedy for the improvement on visual function in patients with normal tension glaucoma (NTG), pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma by Shim SH1, Kim JM, Choi CY, Kim CY, Park KH. (PubMed)
(2) Natural therapies for ocular disorders, part two: cataracts and glaucoma by Head KA. (PubMed)
(3) Age related visual impairment in the elderly by Loh KY1, Ogle J. (PubMed)

Navy Bean in the Prevention and Treatment of Chronic Diseases

By Kyle J. Norton

Chronic diseases are a class of condition that last longers than 3 months, leading to long-term symptoms, physical impairments, disabilities.

Most cases of chronic diseases are associated with low-grade inflammation, including arthritis, asthma, cancer, chronic obstructive pulmonary disease, diabetes and some viral diseases such as hepatitis C and acquired immunodeficiency syndrome.

Inflammation is a natural reaction to a systematic immune response which protects our body against the stimuli of invasive pathogens by stimulating the production of the pro-inflammatory cytokines and switching the anti-inflammatory activity of proteins which process duel inflammatory property

Acute inflammation is a result of the immune white blood cell response to tissue damage or injury that lasts less than a few days or weeks. After the foreign invaders are destroyed, the damaged tissues are healed quickly.

Unlike acute inflammation, chronic inflammation is a condition of low-grade inflammation adopted by the immunity caused by the immune inability to kill off all invaders in the acute phase of infection.

In the examined the immune evolution over thousands of year Some researchers suggested that the immune system has evolved to destroy the foreigner pathogens in specific time within 3 -8 weeks, otherwise, it will adapt to the change.

The causes of chronic diseases are vary depending on the types of disease. However, epidemiological studies suggested that primary factors that cause chronic conditions are an unhealthy diet, physical inactivity; tobacco use and the intermediate factors of high blood pressure, glucose levels, and blood lipids, overweight, and obesity are also elevating the risk of chronic diseases. 

The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to their numerous health benefits.

With an aim to find a potential compound for the prevention and treatment of chronic disease, researchers examined the effects of Consumption of Phaseolus vulgaris bean species including, navy beans.

Epidemiologically,

* Navy beans reduce postprandial glucose elevations in short-term studies in non-diabetic and diabetic individuals.

* Navy bean exerted glycaemic control in non-diabetic and diabetic individuals by improving markers of longer-term glycaemic control (HbA1c and fructosamine).

* Navy bean exerted a beneficial effect on short-term satiety and weight loss when combined with energy restriction.

* Navy bean decreased LDL-cholesterol, a well-known risk factor for CVD in normocholesterolaemic and hypercholesterolaemic participants

* Navy beans also reduced the oxidative stress, endothelium-dependent vasodilation, and increased blood pressure associated with increased risk for T2DM, complications of T2DM and CVD.

* Navy bean modulated hormone expression associated with hyperinsulinemia in increasing cancer risk.

Finally, The mechanism of action responsible for the reducing risk chronic disease may be involved in the high content of viscous fiber, protein, relatively high amylose starch, and antinutrients found in navy bean and other Phaseolus vulgaris bean species. 

Based on the findings, researchers concluded, "Traditional foods such as beans should be retained in the diet because of their many health benefits, including a positive impact on postprandial glycaemic response. Hyperglycaemia, whether it occurs following a meal or due to poorly controlled T2DM, is known to increase oxidative stress, contribute to hypertension and increase the risk for CVD".

And "Examination of the glycaemic response to meals, especially culturally important food combinations such as beans and rice, is important for the prevention and control of hyperglycemia-induced diseases".

Taken altogether, the fermented navy bean may be considered a remedy for the prevention and treatment of chronic diseases, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Phaseolus beans: impact on glycaemic response and chronic disease risk in human subjects by Hutchins AM1, Winham DM, Thompson SV. (PubMed)

Bromelain Modulates the Immune Function Against Allergic Airway Disease

By Kyle J. Norton

Inflammation is a natural reaction of the immune system which protects our body against the stimuli of invasive pathogens.

Acute inflammation is a result of the immune white blood cell response to tissue damage or injury by stimulating the production of proinflammatory cytokines during the acute phase of infection.

Some researchers that the immune has evolved over thousands of year to destroy the foreigner pathogens in specific time within 3 -8 weeks, otherwise, it will adapt to the change, a leading cause of chronic inflammation

Allergic airway inflammation is an abnormal reaction of the immune system towards unharmfully common and environmental factors, such as pollen grains or dust mites. 

Most common diseases associated with allergic airway inflammation are 

* Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood.

*Chronic obstructive pulmonary disease (COPD), the third leading cause of death in the US can be classified into

** Emphysema casued by damage to tissues of the air sacs (alveoli) in the lungs is a type of chronic obstructive pulmonary disease (COPD)associated with a long term and progressive condition cause of shortness of breath but depending to the stage of lung function.

** Chronic bronchitis is a chronic inflammation of the lung’s bronchi that causes the increased production of mucus in the lung induced symptoms of difficulty breathing.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

On finding a potential compound for the treatment of diseases associated with airway inflammation, researchers examined the effect of bromelain effect on reduced inflammation of preexisting asthma via ovalbumin (OVA)-induced murine model of allergic airway disease (AAD).

The study included sensitized female C57BL/6J mice received phosphate-buffered saline (PBS) with intraperitoneal OVA/alum and then challenged them with OVA aerosolization for 10 consecutive days. However, on day 4, daily doses of PBS was administrated to the control group (n = 10) and bromelain (6mg/kg) in PBS to the bromelain (intervention) group (n = 10).

According to the tested analysis, bromelain treatment of AAD mice (bromelain group) exerted a significant anti-inflammatory activity observed by the reduced BAL total leukocytes (P < .05), eosinophils (P < .05), and cellular infiltrates, compared to the control group.

Futhermore, the bromelain treatment group also significantly reduced BAL CD4+ and CD8+ T cells associated with inflammatory progression without affecting cell numbers in the spleen or hilar lymph node.

Levels of pro-inflammatory cytokines such as interleukins IL-4, IL-12, IL-17, as well as IFN-α in the serum of bromelain-treated animals were also reduced compared to control.

More precisely, bromelain inhibited the allergic airway inflammatory disease through modulating the immune responses and inhibiting the expression of a protein associated with pro-inflammation.

Moreover, on mice sensitized with intraperitoneal (i.p.) OVA/alum and challenged with daily OVA aerosols followed by the treatment of either saline, 2 or 6 mg/kg bromelain, twice daily for four consecutive days.

Bromelain treatment of AAD mice showed a similar effect as the aforementioned study by reducing total BAL leukocytes, eosinophils, CD4+ and CD8+ T lymphocytes, CD4+/CD8+ T cell ratio, and IL-13, compared to saline group.

Based on the findings, some researchers suggested that bromelain may have similar effects in the treatment of human asthma and hypersensitivity disorders.

Taken altogether, bromelain may be considered a remedy for the prevention and treatment of allergic airway disease, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma by Secor ER Jr1, Shah SJ, Guernsey LA, Schramm CM, Thrall RS. (PubMed)
(2) Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease by Secor ER Jr1, Carson WF 4th, Cloutier MM, Guernsey LA, Schramm CM, Wu CA, Thrall RS. (PubMed)