Herbal Turmeric Suppresses the Initiation, Progression, and Proliferation of Acute Myeloid Leukemia (AML)

By Kyle J. Norton

Leukemia is a condition characterized by an abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending to the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

Bone marrow is soft tissue inside the hollow center of the major bone. including spine, pelvis, underarm, leg. etc.

Acute leukemia is a condition caused by a rapid increase in the numbers of extreme immature white blood cells which appear in the bloodstream in the other parts of the body, including tissue and organs, Acute leukemia can also be classified into
* Acute lymphoblastic leukemia (ALL)
Acute lymphocytic leukemia (ALL) is a type of cancer of the abnormal growth of extreme immature lymphocytes overproduced by the bone marrow and/or lymphatic system. The condition has a tendency to multiply quickly, leading to the death to normal white blood cells in the bone marrow and/or lymphatic system.

In ALL, lymphocytes appear immature in the bloodstream. Acute lymphoblastic leukemia (ALL) is the most common children forms of leukemia with about 80% of all cases.

* Acute myeloid leukemia (AML)
Acute myelogenous leukemia (AML) is a cancer of myelogenous lining caused by the rapid growth of abnormal granulocytes accumulated in the bone marrow, interfering with the normal blood cells. In AML, granulocytes appear immature in the bloodstream.

Most common risk factors associated with the risk of AML are 

*  Age
Acute myelogenous leukemia (AML) occurs mostly in adults with increased risk with age.

* Gender
Men have an increased risk of Acute myelogenous leukemia (AML) than that of women.

* Radiation
Children with a previous high dose of radiotherapy and chemotherapy have an increased risk of acute lymphoblastic leukemia.

* Exposure to environment chemicals
Exposure to certain chemicals can increase the risk of the disease.

* Previous cancer treatment.
Previous cancer treatment of chemotherapy and radiation therapy increase the risk of AML.

* Smoking
AML is linked to cigarette smoke, as a result of cigarette carcinogens.

* Genetic disorders
Certain inherited genetic disorders, such as Down syndrome, Fanconi anemia, IgA deficiency, etc. increase the risk of the disease.

According to the statistic proved by the American Cancer Society, in 2019, approximately 21,450 new cases of acute myeloid leukemia (AML) will be diagnosed in adults. The disease also causes the
of 10,920 deaths of American adults.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to find a natural compound for the treatment of acute myeloid leukemia cancer, researchers examined the curcumin, a bioactive compound from turmeric, eliminated cancer stem cells (CSCs) in some cancers.

On acute myeloid leukemia cells treated with increasing concentrations of curcumin showed a significant decrease in the markers associated with CSCs.

ALDH activity as a common marker that mediates the metastasis is also inhibited by the injection of curcumin through a decrease in the percentage of ALDH-positive cells.

Colony formation associated with cancer cell proliferation and progression was also suppressed by the activity of curcumin.

Proteins involved in uncontrolled cellular proliferation and oncogene in several other cancers and promotion of cellular division were also inhibited by the administration of the phytochemical.

In other words, curcumin suppression the initiation, progression, and proliferation of acute myeloid leukemia through several mechanisms, including cell cycle arrest, apoptosis, and anti-proliferation.

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of acute myeloid leukemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Evaluation of curcumin, a natural product in turmeric, on Burkitt lymphoma and acute myeloid leukemia cancer stem cell markers by Li Y1, Domina A2, Lim G1, Chang T2, Zhang T. (PubMed)

Phytochemical Alliin Kills Colorectal Cancer Cells In Vitro

By Kyle J. Norton

Colorectal cancer is a chronic and medical condition caused by irregular cell growth in the colon or rectum.

Most cases of colorectal cancer start in the alternation of cell DNA on the surface of the inner lining of the colon or rectum before penetrating deeper into the organs.

Rectal cancer is a slowest growing cancer. Therefore, most cases of colorectal cancer are diagnosed at the advanced stage in the older population.

According to the statistic provided by the Canadian Cancer Society, Colorectal cancer is the 2nd most commonly diagnosed cancer in Canada, besides non-melanoma skin cancer.

In 2017,  over 26,000 Canadians were diagnosed with colorectal cancer representing 13% of all new cancer cases. Colorectal cancer also causes the death of over 9,000 Canadian, accounting for 12% of all cancer deaths.

In general, the 5-year survival rate for people with colorectal cancer is 65%. However, the 5-year survival rate of localized colorectal cancer is about 90%.

Although there are a number of risk factors associated with the onset of colorectal cancer, some researchers suggested the increased obesity in the general population induced colorectal cancer over the past few decades may have a strong implication by the promotion of Western diet.

Dr. Aleksandrova K wrote, "Current research indicates that there is a moderate but consistently reported association between general obesity (as determined by BMI) and colorectal cancer incidence and mortality".

And, "The relative risk associated with obesity is higher for cancer of the colon than for cancer of the rectum and it is higher in men than in women. By contrast, abdominal adiposity (as determined by waist circumference or waist-to-hip ratio) is similarly strongly associated with colon cancer in men and women, suggesting that abdominal adiposity is a more important risk factor for colon cancer than general adiposity, at least in women".

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find potential and natural ingredients for the treatment of colorectal cancer, one among the most common cancers in the world and a major cause of cancer-related deaths, researchers examined the s-allyl-l-cysteine-sulfoxide (SACS)/alliin against overexpression of epidermal growth factor receptor (EGFR).

The organosulfur compounds showed an interaction ability in the active region of the EGFR gene, according to silico molecular docking studies and in vitro validation, leading to the inhibition of EGFR gene in facilitating the cancer cell growth and proliferation.

In other words,  s-allyl-l-cysteine-sulfoxide (SACS)/alliin prevented overexpression of the EGFR gene in the promotion of tumor initiation.

According to the results from the epidemiological studies in China, in the investigated a garlic powder preparation, a garlic extract (reported as 8-10% L(+)-alliin enriched), and a combination anticancer activity.
* Garlic powder failed to inhibit the growth of human colorectal carcinoma Caco2 cells at concentrations of up to 1000 micrograms/ml.

* Garlic extract, in which the alliin content was highly enriched was also unable to inhibit the growth of these cells.

* However, the garlic extract supplemented with garlic powder (to 10% final concentration) in a concentration-dependent clearly inhibited tumor cell growth with IC50 values of 480 micrograms/ml in the Caco-2 cells.

Additional analysis of the aforementioned results, researchers found that the efficacy of in the inhibition of colorectal cancer cell was attributed to the breakdown products of alliin, such as allicin or polysulfides, rather than alliin itself.

These results confirmed by examining the addition of an alliinase system (garlic powder) to an alliin enriched preparation without alliinase (garlic extract)  potentiated the effects.

Taken altogether, alliin used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of colorectal cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) EGFR gene regulation in colorectal cancer cells by garlic phytocompounds with special emphasis on S-Allyl-L-Cysteine Sulfoxide by Roy N1, Nazeem PA2, Babu TD3, Abida PS2, Narayanankutty A3, Valsalan R2, Valsala PA2, Raghavamenon AC. (PubMed)
(2) The effects of garlic preparations against human tumor cell proliferation by Siegers CP1, Steffen B, Röbke A, Pentz R. (PubMed)
(3) Obesity and colorectal cancer by Aleksandrova K1, Nimptsch K, Pischon T. (PubMed)

3,3'-Diindolylmethane Protects the Integrity of Liver Against Chronic Liver Disease

By Kyle J. Norton


Chronic liver diseases are the medical condition that causes the reduce function of the liver. In a serious case, chronic liver disease can lead to liver failure.

In other words, chronic liver diseases are liver diseases that last more than 6 months, including liver viral inflammation, liver cirrhosis, and hepatocellular carcinoma.

The liver is a large organ in the human body that filters out the blood which comes from the intestines before passing them to other parts of the body.

The largest organ also produces cholesterol to aid digestion, build a strong cell wall and produce steroids hormones and vitamin D.

According to the statistics provided by the UK, liver diseases are ranked as the fifth most common cause of death in the UK and have a steady tendency to increase over the years. 

In the US, non-alcoholic fatty liver disease (NAFLD) is the most common liver diseases which affect over 100 100 million Americans.

Non-alcoholic fatty liver disease is a medical condition caused fat accumulated in the liver over time probably due to poor diet and physical inactivity. The disease is one of the major cause of cirrhosis associated with liver cancer and liver failure.

Most common symptoms of chronic liver disease include loss of appetite, jaundice, persistent itching, fluid buildup in the belly, vomiting blood caused by the bleeding of often from bleeding in the esophagus.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

With an aim to discover a potential ingredient which process liver protective effect, researchers investigated the effect of indoles, including indole-3-carbinol (I3C) and its derivatives I3C polymerizes into 3, 3- diindolylmethane (DIM) on chronic liver disease.

In vivo and vitro, indoles showed to regulate transcriptional factors and their respective signaling pathways associated with the production of proteins involved in the pro-inflammatory expression.

Furthermore, indoles also promoted the production of antioxidant enzymes against overexpression of levels of free radicals induced oxidative stress.

Moreover, administration of indoles in vivo and vitro also inhibited microRNA to influence the activation, proliferation, and apoptosis of target liver cells.

In other words, indoles protect the liver integrity by modulating the enzymes involved in hepatitis viral replication, lipogenesis, and the metabolism of ethanol and some hepatotoxicity.

Additonally, the bioactive compound was also found to process immunomodulatory biofunction in improving non-alcoholic steatohepatitis. 

Overall, the indole liver protective effects were attributed to its function as anti-inflammatory cytokines and chemokines to reduce microbial-induced liver injuries inhibitors.

Dr. Wang SQ, the lead scientist said, "Indoles, especially I3C and DIM as phytochemicals, exert anti-fibrosis, anti-tumor, anti-oxidant, immunomodulatory, detoxification and anti-inflammation effects on hepatic protection through pleiotropic mechanism".

Taken altogether, indoles, including 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered supplements for the prevention and treatment of chronic liver disease pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3, 3'-Diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance by Liu Y1, She W1, Wang F1, Li J2, Wang J1, Jiang W. (PubMed)
(2) Indole-3-Carbinol (I3C) and its Major Derivatives: Their Pharmacokinetics and Important Roles in Hepatic Protection by Wang SQ, Cheng LS, Liu Y, Wang JY, Jiang W. (PubMed)

Bromelain, Inhibits Melanoma in Vitro and Vivo

By Kyle J. Norton

Melanoma is a type of skin cancer caused by the alternation of DNA of the cells from the pigment-containing cells known as melanocytes.

Most cases of melanoma start in melanocytes on skin before spreading to the nearby tissue. In the advanced stage, the cancer cells can also travel a distance away from the originated site to infect other tissues and organ, leading to secondary metastasis, through the circulation of blood and fluids.

Most common sites of melanoma metastasis are the lung and breast.

Most common symptoms are visible by examing the change of skin, including the sores that can not heal itself, redness or swelling, persistent itching, tenderness and pain and particular, change of skin color and bleeding off of a mole compared to the normal moles.

If you are experiencing some of the aforementioned symptoms, please check with your doctor to rule out the possibility.

According to the statistics provided by the American Cancer Society, in 2019, approximately, 96,480 new melanomas will be diagnosed (about 57,220 in men and 39,260 in women) in the US. The condition also causes the death of 4,740 men and 2,490 women.

Believe it or not. most cases of melanoma are found in older adults. The average age diagnosed with melanoma is 63.

Compared to African Americans, melanoma is more than 20 times more common in whites.

Out of many risk factors associated with the onset of melanoma, some researchers suggested the misunderstanding of the health benefits and adverse effect of sun and tanning exposure may be the leading cause of melanoma.

Dr. Caroline Chang, the lead scientist said, "Despite advances in its detection and treatment, melanoma remains the primary cause of mortality from skin disease in the Western world.". 

And, "Several personal risk factors for developing melanoma are well established, including family history, multiple moles, fair skin, blue eyes, red hair, and freckles.3Environmental exposures, chiefly from UV radiation, including outdoor sunburns and indoor tanning exposure, also have been associated with increased melanoma risk".

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a natural ingredient against melanoma, researchers examined the effects of Bromelain pharmacological activity on B16F10 murine melanoma cells in vitro.

Compared to other parts of the plant, the highest enzymatic activity that was found in bromelain extracted from the pulp and peels and the optimum bromelain pH among all studied pineapple parts was 6.0 in a temperature above 50 °C in all bromelain extracts.

According to the results from the tested assays, bromelain showed a pharmacological activity against B16F10 melanoma cells by inhibiting 100% of tumor cell proliferation in vitro.

Based on the results, researchers said, "Since bromelain activity was found in different parts of pineapple plants, pineapple residues from the food industry may be used for bromelain extraction".

Furthermore, in melanoma-A375 cells, application of bromelain exhibited a reduction in proliferation and suppressed their potential for anchorage-independent growth through its anti-inflammatory activity.

Moreover, bromelain was found to inhibit the melanoma-A375 cells by depleting intracellular glutathione and generating reactive oxygen species followed by mitochondrial membrane depolarization.

Bromelain-induced cell-cycle arrest at G(2)/M phase by exhibiting the expression of proteins associated with cell cycle arrest.

Additionally, bromelain increased the expression of proapoptotic and anti-proliferative proteins that cause apoptosis of the tested cell line.

Dr. Bhui K, the lead scientist wrote, "Bromelain afforded substantial anti-cancer potential in these settings; hence we suggest it as a potential prospect for anti-cancer agent besides only an additive in chemotherapy".

Taken altogether, bromelain may be considered supplements for the prevention and treatment of melanoma, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The biochemical characterization, stabilization studies and the antiproliferative effect of bromelain against B16F10 murine melanoma cells by São Paulo Barretto Miranda ÍK1, Fontes Suzart Miranda A2, Souza FV3, Vannier-Santos MA2, Pirovani CP4, Pepe IM5, Rodowanski IJ5, Ferreira KT4, Mendes Souza Vaz L6, de Assis SA. (PubMed)
(2) Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2)/M arrest to apoptosis by Bhui K1, Tyagi S, Srivastava AK, Singh M, Roy P, Singh R, Shukla Y. (PubMed)
(3) More Skin, More Sun, More Tan, More Melanoma by Caroline Chang, MD, Era Caterina Murzaku, BS, Lauren Penn, MD, Naheed R. Abbasi, MD, MPH, Paula D. Davis, MFA, Marianne Berwick, PhD, MPH, and David Polsky, MD, PhD. (PMC)

Healthy Food Tomato Induces Cytotoxicity Against Cancer Cells

By Kyle J. Norton

Cytotoxicity is the process in the induction of cell death through toxins.

In other words, cell cytotoxicity is the process to use certain chemicals or mediator cells to destroy living cells.

In normal, cytotoxicity can cause the death of healthy cells

In cancers, cytotoxicity can be benefits to human by destroying the cancer cells and prevent them from proliferation.

For example, cytotoxicity induced by oxidative stress due to the imbalanced ratio of free radicals and antioxidant enzymes produced by the body can cause protein, lipid and cellular damage that leads to chronic low-grade inflammatory diseases and cancer.

However, stimulation of ROS and antioxidants production to induce cytotoxicity to the tumors can also cause cancer cell death without damage to nearby healthy cells.

Dr. Shikha Srivastava, the lead scientist in the evaluation of the antioxidant and cytotoxic properties in Quercetin,  wrote, "quercetin interacts with DNA directly, and could be one of the mechanisms for inducing apoptosis in both, cancer cell lines and tumor tissues by activating the intrinsic pathway".

And, " quercetin-induced cytotoxicity in leukemic cells in a dose-dependent manner, while ellagic acid showed only limited toxicity. Besides leukemic cells, quercetin also induced cytotoxicity in breast cancer cells, however, its effect on normal cells was limited or none".

Scientifically, most cases of cancer cells cytotoxicity are associated with the stimulation of protein and pathways involved in either gene suppression or cell death programming.

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In the urgency to find a natural ingredient that kills cancer without inducing adverse effects, researchers examined the toxicity against human gastric adenocarcinoma cells (AGS) and the antioxidant activity of hydromethanol (HME), acetone (AcE) and alkaloid (AE) extracts prepared from the leaves of the tomato plant. 

Both HME and AcE extracts showed a significant effect in scavenging •NO (IC50 values ranged from 0.87 ± 0.12 to 1.54 ± 0.23 and from 0.90 ± 0.01 to 2.23 ± 0.14 mg mL-1, respectively), compared to HMEs that only scavenge O2•- showing IC50 values from 0.12 ± ≤0.01 to 0.43 ± 0.08 mg mL-1.

In other words, tomato extracts demonstrated a strong effect against human gastric adenocarcinoma cells (AGS) through its cytotoxicity without causing harm to normal cells through the antioxidant activity.

Furthermore, in the study to assess different varieties of tomato seed extracts potential antioxidant and/or antiproliferative activity, researchers found that San Marzano Rosso seed extract displays the highest free radical-scavenging activity with 68% of 2,2-Diphenyl-1-picrylhydrazyl radical inhibition.

Moreover, according to the brine shrimp test (LD50: 23,198 ppm), San Marzano Rosso seed extract also demonstrated the highest cytotoxicity against A375 cell line, compared to other variety.

Taken altogether, tomato and its leaves may be considered supplements for the prevention and treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tomato in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Further insights on tomato plant: Cytotoxic and antioxidant activity of leaf extracts in human gastric cells by Figueiredo-González M1, Valentão P1, Pereira DM1, Andrade PB. (PubMed)
(2) Antioxidant and cytotoxic activities investigation of tomato seed extracts by Tommonaro G1, Caporale A, De Martino L, Popolo A, De Prisco R, Nicolaus B, Abbamondi GR, Saturnino C. (PubMed)
(3) Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell. Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis by Shikha Srivastava, Ranganatha R. Somasagara, Mahesh Hegde, Mayilaadumveettil Nishana, Satish Kumar Tadi, Mrinal Srivastava, Bibha Choudhary & Sathees C. Raghavan. (Scientific Report)

Herbal Turmeric Normalizes the Levels of Blood Cholesterol (LDL) and Triglycerides (TC) in Patients with Increased Risk of Cardiovascular Disease (CVD)

By Kyle J. Norton


Abnormal blood lipids profile included high cholesterol and triglycerides has been found to associate with an increased risk of developing cardiovascular disease (CVD).

Lipid profile test is a blood test that measures the levels of cholesterol and triglycerides in patients with a high risk of cardiovascular disease.

There are 2 types of blood cholesterol
* The low-density lipoprotein (LDL) produced by either the liver or dietary sources plays an essential role in the production of vitamin D, a steroid hormone, building strong cell membranes and aiding the digestive function in the absorption of nutrients.

* The other type of cholesterol is high-density lipoprotein (HDL) which has a unit function in returning the blood cholesterol to the liver for future use.

The healthy ration of LDL/HDL is any number less than 4.

Triglycerides (TC) are a type of fat stored in fat cells due to excess calories consumed. Triglycerides are converted to energy when it is needed by the body.

Although Triglycerides (TC) is needed for good health, however, regularly eat more calories than you burn, may induce hypertriglyceridemia, one of the leading cause of hardening of the arteries or thickening of the artery walls.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a natural ingredient for the normalization of LDL and TC, researchers conducted a meta-analysis to assess the efficacy and safety of turmeric and curcumin in lowering blood lipids in patients at risk of cardiovascular disease (CVD).

The study included the search for comprehensive literature search was conducted on PubMed, Embase, Ovid, Medline and Cochrane Library databases to identify randomized controlled trials (published as of November 2016) satisfied the standard guidelines and criteria.

The 7 eligible studies including 649 patients showed that turmeric extract and curcumin significantly reduced serum LDL-C and TG levels, compared to those in the control group.

Administration of both turmeric extract and curcumin lower serum TC levels in patients with metabolic syndrome. However, turmeric extract possibly has a greater effect on reducing serum TC levels compared to those of curcumin.

Both turmeric extract and curcumin showed no effect on the serum HDL-C levels and are safe.

Dr. Qin S, the lead scientist said, "Turmeric and curcumin may protect patients at risk of CVD through improving serum lipid levels. Curcumin may be used as a well-tolerated dietary adjunct to conventional drugs".

In order to obtain more information about turmeric activity on lipid profile, researchers investigated the efficacy of curcuminoid fraction from Curcuma xanthorrhiza and its curcuminoid cider in reducing blood cholesterol level and four genes related to oxidative stress.

The study included 24 male Sprague-Dawley rats divided into six groups, namely normal group diet, high-cholesterol diet (HCD) 2%, HCD + 100 mg/kg b.w. curcuminoid fraction, HCD + 300 mg/kg b.w. curcuminoid fraction, HCD + cider 1% v/v, and HCD + curcuminoid cider 2% v/v for 4 weeks.

All curcuminoid cider at 2% v/v treatment groups showed a significantly lowered total cholesterol level compared to those of positive control.

According to the results from the Real-time PCR data, both curcuminoid fractions (100 and 300 mg/kg) and curcuminoid cider (1 and 2% v/v) inhibited the gene expression associated with lipid peroxidation.

Based on the findings, researchers wrote in the final report, "Oral administration of curcuminoid fraction and its cider product may exert potential inhibitory effects on oxidative stress related-genes for preventing hypercholesterolemia-induced atherosclerosis in vivo".

Taken altogether, turmeric processed a high amount of curcumin may be used for the prevention and treatment of abnormal blood lipid profile,, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials by Qin S1, Huang L1, Gong J1,2, Shen S1,2, Huang J1,2, Ren H2, Hu H. (PubMed)
(2) Efficacy of Oral Curcuminoid Fraction from Curcuma xanthorrhiza and Curcuminoid Cider in High-cholesterol Fed Rats by Mauren FM1, Yanti2, Lay BW. (PubMed)

Phytochemical Betacyanins, the Best Free Radical Scavenger

By Kyle J. Norton

Free radical scavengers are types of antioxidants that inhibit free radicals before they can induce a chain of reaction, leading to the onset of oxidative stress.

Antioxidants are stable atoms which inhibit oxidation caused by free radical.

Oxidative stress associated with chronic disease is caused by long-term imbalanced ratio of free radicals and antioxidants. Oxidative stress has been found epidemiologically to induce proteins, lipid, and cellular damage, a major causes of heart disease, stroke, and diabetes.

Antioxidants besides produced by the body, they can also come into the body from the dietary sources.

Normally, in a healthy individual, antioxidant enzymes produced by the liver are more than enough to counter the expression of free radicals induced by cell metabolism and the environment such as the air we breathe and the food we eat.

However, people with a weakened immune system, intake of antioxidant from outside sources such as fruits and vegetables can be helpful.

Not all free radicals are bad, in a moderate amount, free radicals are necessary for the body functioning, including the promotion of heart function in blood circulation.

Most common types of free radical scavengers produced by the human
* Catalases are antioxidants that protect the cell from oxidative damage by decomposed hydrogen peroxide to water and oxygen.

*Glutathione peroxidase, is a cytosolic enzyme produced by the host that dissolves hydrogen peroxide to water and oxygen and peroxide radicals to alcohols and oxygen.

*Superoxide dismutase (SOD)  dissolves superoxide radical into either ordinary molecular oxygen or hydrogen peroxide.

Most common types of free radical scavenger injected by the dietary sources
* Phenolics has been found to inactivate certain free radicals such as tocopherol found in tea, soybean, corn, grape, and safflower,

* Ascorbate or vitamin C is found most abundantly in green vegetables, citrus fruits, tomatoes, berries, and potatoes.

* Thiols that processed the function to quench singlet oxygen is found in onion, garlic, beer, cabbage, tea, and coffee

* Carotenoids that process the function in the deactivation of free radical with singlet oxygen, are found in tomato and carrot

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.

On finding a natural pigment which processes a significant antioxidant activity, researchers examined the Betacyanins effects on peroxyl radicals.

Based on the results of the tested assays, researchers found that

* Betanin found in betacyanins was a weak retarder in methanol and an effective chain-breaking antioxidant in the liposomal model

* Compared to betanin, betanidin other compound found betacyanins, behaved as a chain terminating antioxidant in both models.

Furthermore, according to the kinetic parameters characterizing peroxyl radical-scavenging activity, betanidin was more effective than betanin.

The results suggested that the antioxidant efficacy found in betacyanins was associated with all phytochemicals, including the major compound betanin and betanidin that work synergistically to exhibit anti-free radicals activity.

Moreover, in the assessment of the antioxidant capacity of the betacyanins in an index of radical scavenging ability, using the peroxyl radical generating system in the presence of AAPH and NO-generating system using NOR3 as a NO donor suggested that

* Betacyanins expressed peroxyl radical scavenging capacity in a dose-dependent in the low concentration range (25-100 nM).

* In free radical NO, administration of betacyanins also reduced the nitrite-level in the low concentration range of 2.5-20 μM.

* The antioxidant capacity according to individual major compounds of betanidin, betanin, and phyllocactin, are 10.70, 3.31 and 2.83 mol-TEA/mol respectively.

* The The IC₅₀ values (μM) of nitrogen radical scavenging activity of betanin, phyllocactin and betanidin.are 24.48, 17.51 and 6.81, respectively.

Dr. Taira J, the lead scientist based on the findings wrote, "These results indicated that betacyanins have a strong antioxidant capacity, particularly betanidin with a catechol group had higher activity than those of the glycoside of betacyanins".

Taken altogether, betacyanins processed abundantly bioactive ingredient betanin may be considered a remedy for the prevention and treatment of liver steatosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Betacyanins as phenol antioxidants. Chemistry and mechanistic aspects of the lipoperoxyl radical-scavenging activity in solution and liposomes by Tesoriere L1, Allegra M, Gentile C, Livrea MA.(PubMed)
(2) Antioxidant capacity of betacyanins as radical scavengers for peroxyl radical and nitric oxide by Taira J1, Tsuchida E2, Katoh MC2, Uehara M2, Ogi T. (PubMed)