Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Wednesday, 15 May 2019

Bromelain, Stops Colon Cancer Developing in Vitro and Vivo

By Kyle J. Norton

Colon cancer is a medical condition caused by irregular cell growth in the colon tissues.

The colon formed part of the large intestine is a part of the digestive system with function to reabsorb fluids and eliminate waste products from the body.

Most cases of colon cancer start in the cells on the surface of the inner lining tissue, before colonizing the deeper tissues.

Colon cancer is one of the slowest growth of tumors. The onset of cancer may sometimes take 20 years before the cancer symptoms are developed.

Most cases of colon cancer in the early stage are asymptomatic due to the very small size of cancer. However, at the advanced stage, colon cancer cells can travel a distance away to infect other healthy tissues and organs.

According to the statistics, in the US, approximately 1 million people are living with colon cancer. Every year, approximately 100,000 new cases of colon cancer are diagnosed.

Overall, the lifetime risk of colorectal cancer is 1 in 22 (4.49%) for men, compared to 1 in 24 (4.15%) for women.

Older age, African-American race, people with family and personal history and inflammatory bowel disease and physical inactivity are some prevalent factors found in patients with the disease.

However, some researchers in the concern that colon cancer in the younger adult group suggested that the promotion of a high-fat diet over the past few decades may contribute to the increased risk of colon cancer in the US.

Dr. David Liska, MD, a colorectal surgeon at the Cleveland Clinic. wrote, "“The rise in colorectal rates in younger adults has been parallel to the rise in the obesity epidemic, so it’s reasonable to think that that’s a factor”.

And, “Many of the risk factors for obesity are also risk factors for colon cancer, including a high-fat diet that’s high in red meat and low in vegetables, as well as being sedentary. But I’m seeing a lot of younger patients who are at a normal weight and have a healthy lifestyle, so there have to be other reasons”.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

In the urgency to find a natural ingredient for the treatment of colon cancer, researchers examined the possible antiproliferative/proapoptotic effects of bromelain (from the pineapple stem Ananas comosus L., family Bromeliaceae) in a human colorectal carcinoma cell line and its potential chemopreventive effect in a murine model of colon cancer.

On human colon adenocarcinoma (Caco-2) cells, according to the tested assays, administration of bromelain inhibited proteins expression associated with cell proliferation, anti-apoptosis, and reduction of reactive oxygen species production.

Furthermore, in vivo, bromelain exerts the similar effects on colon carcinogenesis through its antiproliferative and proapoptotic activity and enhanced chemopreventive actions.

In other words, bromelain protected the colonic cell viability by preventing the risk of developing aberrant crypt foci, polyps, and tumors induced by azoxymethane.

Dr. Romano B, the lead scientist said, "Bromelain-containing foods and/or bromelain itself may represent good candidates for colorectal cancer chemoprevention".

In order to reveal more information about the bromelain property on colon cancer, researchers in the cancer team at the Wonkwang University examined the bromelain activity in Kras mutant human colorectal carcinoma cell lines and a mouse model harboring a Kras mutation.

In the Kras mutant colorectal carcinoma cell lines, administration of 50 μg/mL bromelain reduced the cell growth and proliferation correlated to the inhibition of enzyme ACSL-4 involved in the promotion of cancer cell growth, invasion, and hormonal resistance and exhibited the microRNAs (miRNAs) that regulate the gene expression of ACSL-4.

Compared to the Kras wild-type colorectal cancer cells, bromelain effectively exerts cytotoxic effects in Kras mutant colorectal cancer cells.

In other words, bromelain demonstrated a significant effect in reduced colon cancer cells growth and anti-apoptosis by blocking the gene expression associated with such action through regulating its microRNAs.

Based on the findings, Researchers said, "Differential expression of ACSL-4 is responsible for the differential action of bromelain in regulating ferroptotic cell death".

Taken altogether, bromelain may be considered supplements for the prevention and treatment of colon cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) The chemopreventive action of bromelain, from pineapple stem (Ananas comosus L.), on colon carcinogenesis is related to antiproliferative and proapoptotic effects by Romano B1, Fasolino I, Pagano E, Capasso R, Pace S, De Rosa G, Milic N, Orlando P, Izzo AA, Borrelli F. (PubMed)
(2) Bromelain effectively suppresses Kras-mutant colorectal cancer by stimulating ferroptosis by Park S1, Oh J1, Kim M1, Jin EJ. (PubMed)
(3) This cancer is on the rise in young adults — and doctors don’t know why. (Yahoo Lifestyle)

Tuesday, 14 May 2019

Herbal Turmeric Protects Diabetics Against Diabetic Retinopathy

By Kyle J. Norton

Diabetic retinopathy is one of the diabetes complication caused by long-term uncontrol levels of blood glucose in patients with diabetes, leading to vision loss.

Diabetic macular edema (DME) is swelling in an area of the retinal macula, a consequence of diabetic retinopathy.

The cause of diabetic retinopathy is a result of unmanageable high blood sugar from diabetes associated with damage to the tiny blood vessels in the retina.

Other eye diseases often found in patients with uncontrol blood glucose are

* Cataract, a condition of clouding of the eye’s lens.

Believe or not, patients with diabetes are 2-5 times more likely to develop cataract compared to a healthy individual.

* Glaucoma, a group of diseases that damage the eye’s optic nerve that connects the eye to the brain. Diabetic has nearly doubled the risk of glaucoma, compared to nondiabetics.

At the early stage of hyperglycemia, most patients are asymptomatic. However, at the later stage, the condition affects vision caused bt eh bleeding from abnormal retinal blood vessels.

Conventionally, diabetic retinopathy diagnosed and treated early were found to reduce diabetic retinopathy risk by 95%. However, late-stage diabetic retinopathy may cause irreversible vision loss.

Please make sure you have eye exams more frequently for preventive measure.

By managing your blood glucose by changing lifestyle with moderate exercise and taking your medication as direct diabetic retinopathy may be preventable.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to find a potential ingredient for the prevention of diabetic complications, researchers examined the effect of curcumin, an active ingredient of turmeric on diabetic retinopathy.

In vivo, curcumin inhibited proliferation of retinal endothelial cells in tested animals.

Curcumolide, a bioactive compound found in turmeric, demonstrates a significant effect in alleviating retinal inflammatory activities both in vitro.

In vivo of STZ-induced diabetic rat model and in TNF-α-stimulated HUVECs, injection of curcumolide exerted anti-inflammatory effects against the inflammatory induction of retinal damage.

Furthermore, curcumolide also alleviated retinal vascular permeability and leukostasis and attenuated the overexpression of proinflammatory cytokines in diabetic retinas.

Based on the findings, researchers wrote in the final report, "These data suggest potential treatment strategies against diabetic retinopathy, particularly in the early stages of the disease".

Taken altogether, turmeric processed a high amount of curcumolide may be considered supplements for the prevention and treatment of diabetic retinopathy, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

(1) Diabetic retinopathy: an Indian perspective by Rema M1, Pradeepa R. (PubMed)

(2) Therapeutic potential of curcumin in major retinal pathologies by Peddada KV1, Brown A2, Verma V3, Nebbioso M. (PubMed)

(3) Curcumolide reduces diabetic retinal vascular leukostasis and leakage partly via inhibition of the p38MAPK/NF-κ B signaling by Cai Y1, Li W1, Tu H1, Chen N1, Zhong Z1, Yan P1, Dong J. (PubMed)

Herbal Bilberry, The Best Functional Food For Nonalcoholic Fatty Liver Disease (NAFLD)

By Kyle J. Norton

Nonalcoholic fatty liver disease (NAFLD) is a type of noninflammatory fatty liver disease caused by fat accumulated in the liver other than excessive alcohol consumption.

People who have an accumulation of triglycerides within hepatocytes that exceeds 5% of liver weight are considered to have nonalcoholic fatty liver disease.

According to the statistics, nonalcoholic fatty liver disease (NAFLD) has risen rapidly over the past few decades and become the most common cause of chronic liver disease in the developing world. The disease affects between 17-30% of the population in Western countries and 2-4% worldwide.

Epidemiologically. obesity, type II diabetes, dyslipidemia, and insulin resistance are the well-known primary causes of NAFLD.

The findings strongly suggested that NAFLD is a geographically related disease associated with dietary patterns.

Dr. Alanna McCarthy, the lead scientist in the examination of diet pattern in the risk NAFLD wrote, "Non-alcoholic fatty liver disease (NAFLD) is a serious consequence of high-fat diet intake and currently affects approximately one-third of the world’s entire population".

And, "Recent evidence suggests that patients with NAFLD have a higher incidence of cardiovascular disease compared to the general population. However, little is known about the link between NAFLD and pathological cardiac remodeling leading to heart disease".

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

With an aim to find natural prevention and treatment of non-alcoholic fatty liver disease (NAFLD), researchers investigated the effects of anthocyanin supplementation on insulin resistance and liver injury biomarkers in patients.

74 subjects with NAFLD included in the study were divided into 2 groups in this double-blind, randomized study. Patients received either purified anthocyanin (320 mg/d) derived from bilberry and black currant or placebo for 12 weeks.

During the experiment, the anthocyanin group exhibited significantly decreased in plasma alanine aminotransferase, cytokeratin-18 M30 fragment, and myeloperoxidase, the biomarkers associated with NAFLD, compared to controls.

Compared to the baseline, the anthocyanin group significantly decreased in fasting blood glucose and homeostasis model assessment for insulin resistance, however, these differences were not significant relative to placebo controls.

Not surprisingly, anthocyanin supplementation significantly decreased the 2-hour loading glucose level compared to control, according to the oral glucose tolerance test.

Based on the findings, researchers said, "A 12-week supplement of purified anthocyanin improved insulin resistance, indicators of liver injury, and clinical evolution in NAFLD patients".

Furthermore, according to the results from the study of ApoE(∗)3Leiden mice fed a Western-type cholesterol-containing diet without (HC) or with 0.1% (w/w) Mirtoselect (HCM), an anthocyanin-rich bilberry extract for 20weeks on diet-induced NASH, Mirtoselect treatment group showed an attenuated HC-induced hepatic steatosis and reduced hepatic cholesteryl ester content.

Furthermore, injection of Mirtoselect also exerted local anti-inflammatory effects in the liver by reduced inflammatory cell clusters and neutrophil infiltration in HCM.

In other words, HCM protected the liver against HC diet significantly induced hepatic expression of pro-inflammatory and pro-fibrotic genes associated with the onset of NAFLD.

Dr. Morrison MC, the lead scientist, after taking other factors into account wrote, "Mirtoselect attenuates the development of NASH, reducing hepatic lipid accumulation, inflammation, and fibrosis, possibly mediated by local anti-inflammatory effects associated with reduced accumulation and crystallization of intrahepatic free cholesterol".

Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functioning remedy for the treatment of nonalcoholic fatty liver disease, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) A CONSORT-compliant, randomized, double-blind, placebo-controlled pilot trial of purified anthocyanin in patients with nonalcoholic fatty liver disease by Zhang PW1, Chen FX, Li D, Ling WH, Guo HH. (PubMed)
(2) Mirtoselect, an anthocyanin-rich bilberry extract, attenuates non-alcoholic steatohepatitis and associated fibrosis in ApoE(∗)3Leiden mice by Morrison MC1, Liang W2, Mulder P2, Verschuren L2, Pieterman E2, Toet K2, Heeringa P3, Wielinga PY2, Kooistra T2, Kleemann R. (PubMed)
(3) High-Fat-Diet Induced Non-Alcoholic Fatty Liver Disease and Cardiac Physiology in Mice by
Alanna McCarthy and Stephen Luckey. (Faseb Journal)

Whole Food Tomato Promotes the Lung Function in Human Trials

By Kyle J. Norton

The lung formed part of the circulatory system plays an essential and unique role in taking oxygen to the blood and exhaling carbon dioxide from the blood.

Additonally, the lung also processes other ability in protecting our body against disease, including
* By balancing the pH levels, the lung protects the body against the accumulation of too much carbon dioxide. High levels of carbon dioxide are known to induce acidity in the body.

* By removing small blood clots the lung protects the body against the forming air embolisms.

* The air flow produced by the lung also help us to speak.

* The lung also protects the infection through the secretion of immunoglobulin A.

Any part of the lung injury can reduce the lung function, leading to either obstructive or restrictive lung diseases or mixed lung disease, depending on a person's breathing.

* Obstructive lung diseases are the condition in which the lungs are unable to expel air properly during exhalation. Diseases associated with obstruction lung diseases are asthma, bronchiectasis, COPD, and emphysema.

* Restrictive lung diseases are a condition of decreased lung capacity or volume. Diseases associated with restrictive lung diseases include idiopathic pulmonary fibrosis. Sarcoidosis, an autoimmune disease.

* Mixed lung diseases are most common in people with chronic obstructive pulmonary disease (COPD).

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

With an aim to find a natural and potential remedy for the improvement of lung function, researchers examined the tomato intake on the relationship between lung function decline and dietary antioxidants over 10 years in adults from three European countries.

According to the questionnaire and underwent spirometry (forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC)), there is an association between annual lung function decline (mL) and diet (tertiles).
In other words, tomato intake was also associated with a slower decline in FVC (4.5 mL·year-1; 95% CI 1.28, 8.02).

Compared to those of banana and apple intake, only tomato intake remained statistically significant after the Simes' procedure was performed

Intake of tomatoes also found to delay lung function decline in adults, particularly in ex-smokers.

Additionally, in patients with allergic rhinitis.associated with abnormal airway function such as an obstruction in large or small airways and increased bronchial reactivity, researchers investigated the oral administration of TE (360 mg per day) or placebo for 8 weeks.

According to the tested assays, sneezing score significantly decreased in the TE group at the end of the trial compared to the baseline.

TE group also showed a declined tendencies of rhinorrhea and nasal obstruction.

Compared to the placebo group, the TE group improved the patients' quality of life significantly after 8 weeks of treatment (P < 0.05).

In other words, TE promoted lung function by improving significantly total symptom scores, combining sneezing, rhinorrhea and nasal obstruction.

Taken altogether, tomatoes may be considered supplements for the improvement of lung function, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Dietary antioxidants and 10-year lung function decline in adults from the ECRHS survey by Garcia-Larsen V1, Potts JF2, Omenaas E3, Heinrich J4, Svanes C5, Garcia-Aymerich J6, Burney PG2,7, Jarvis DL. (PubMed)
(2) An evaluation of the clinical efficacy of tomato extract for perennial allergic rhinitis by Yoshimura M1, Enomoto T, Dake Y, Okuno Y, Ikeda H, Cheng L, Obata A. (PubMed)

Phytochemical Alliin Eradicates Ovarian Cancer Cells in Vitro and Vivo

By Kyle J. Norton

The ovaries are an oval-shaped ovum-producing reproductive organ formed part of a woman's reproductive system connected to the fallopian tubes and attached to the outer layer of the uterus via the ovarian ligament.

Usually, the left and right ovary take a turn to release an egg every month.

Ovarian cancer a medical condition of abnormal cells grow in the tissues of the ovary.

It is one of most common cancer in the US, according to the statistics adapted from the American Cancer Society, in 2010, approximately, 21,880 women in the United States were diagnosed with ovarian cancer and ovarian cancer also causes the death of 13,850 women.

The exact causes of ovarian cancer are not identified. However, most common prevalent factors associated with the onset are

* Age
The risk of ovarian cancer increases for women between 50 to 70 years of age.

* Heredity
Women who carry certain mutation genes such as BRCA1 and BRCA2 account for 5%–13% of ovarian cancers.

* Family history
Increased risk of the disease, if one of your direct member family has a history of cancer.

*Never pregnant
Researchers found that the risk of ovarian cancer is lower with numbers of pregnancy.

* Race
White women are associated with a higher risk than other race.

* Hormone therapy
Risk of ovarian cancer increase with the use of hormone replacement therapy in post-menopausal women.

* Chemicals exposures
Certain chemicals such as asbestos also increase the risk of ovarian cancer

* High fat dietary
Researchers found that women who diet high in saturated fat and trans fat are at higher risk.

* Fertility Medication
Drugs used to enhance fertility such as Clomiphene citrate may increase the risk of ovarian cancer.

*Milk
In a report According to the BBC, researchers found that women who drank two or more glasses a day were at double the risk of those who did not consume it at all, or only in small amounts.

Dr. Ellen Løkkegaard, MD, Ph.D.; the lead scientist wrote, "In an average of 8.0 years of follow-up (7.3 million women-years), 3068 incident ovarian cancers, of which 2681 were epithelial cancers, were detected. Compared with women who never took hormone therapy, current users of hormones had incidence rate ratios for all ovarian cancers of 1.38 (95% confidence interval [CI], 1.26-1.51) and 1.44 (95% CI, 1.30-1.58) for epithelial ovarian cancer".

And, "Regardless of the duration of use, the formulation, estrogen dose, regimen, progestin type, and route of administration, hormone therapy was associated with an increased risk of ovarian cancer".

In other words, postmenopausal women who take hormone therapy are at an increased risk of ovarian cancer compared to those who do not.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

In the urgency to find a potential ingredient for the treatment of ovarian cancer, researchers examined the effect of phytochemical alliin as a chemical conjugate between daidzein and the garlic enzyme alliinase on ovarian cancer cells.

In vitro, daidzein-alliinase-CyTE-777 conjugates, according to the NIR and bioluminescence imaging exerted a significant anti antitumor effect.

In vivo, treatment of tumor-bearing mice with daidzein-alliinase and alliin effectively attenuated tumor progression during the first 12 days compared to 5-fold increase in bioluminescence detected in placebo-treated animals.

Furthermore, according to the Histological examination of organs and tissues, daidzein-alliinase and alliin induced cytotoxicity against ovarian cancer cells without causing harm to nearby healthy cells.

In other words, there were no additional foci of carcinoma or signs of toxicity.

Based on the findings, researchers said, "the targeted alliinase conjugates in the presence of alliin, generated therapeutically effective levels of allicin which were capable of suppressing tumor progression of intraperitoneal ovarian cancer in an animal model".

Taken altogether, alliin used alone or combined with another herbal remedy may be considered supplements for the prevention and treatment of ovarian cancer, pending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Conjugates of daidzein-alliinase as a targeted pro-drug enzyme system against ovarian carcinoma by Appel E1, Rabinkov A, Neeman M, Kohen F, Mirelman D. (PubMed)
(2) Hormone Therapy and Ovarian Cancer by Lina Steinrud Mørch, MSc; Ellen Løkkegaard, MD, Ph.D.; Anne Helms Andreasen, MSc. (the Jama Network)

Monday, 13 May 2019

Herbal Artichoke May Process Anti Chronic Myeloid Leukemia (CML) Potency, According Medical Literature

By Kyle J. Norton

Artichoke may be the next target to extract the ingredient needed for the treatment of chronic myeloid leukemia (CML), according to studies.

Chronic myeloid leukemia (CML) is a type of cancer characterized by the increased and unregulated growth of myeloid cells in the bone marrow and the accumulation of these cells in the blood.

The exact causes of CML are unknown. Some researchers suggested that the causes of DNA alternation of the myeloid cells may be associated with the abnormal function of genes involved cell cycle division and tumor suppression.

Epidemiologically, most people with CML are associated with risk factors of aging, male gender and long-term exposure to radiation. However, most people with some of the risk factors do not develop CML.

According to the statistic provided by the American Cancer Society, in 2018, about 8,430 new cases will be diagnosed with CML (4,980 in men and 3,450 in women). The disease also causes the death of 1,090 people, including 620 men and 470 women.

Most common symptoms of CML include easy bleeding and tired, unintended weight loss, pain or fullness below the ribs on the left side, pale skin.

If you experience some of the above symptoms, please check with your doctor to rule out the possibility of the disease.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.

Researchers on finding a natural compound for the treatment of chronic myeloid leukemia evaluated the methanol extract of CCL flower and/or cynaropicrin showed remarkable anti-proliferative activity in vitro models of the leukocyte cancer cell.

In other words, the study was carried out to examined the effect of CCL extract on human K562 CML and K562 imatinib resistant (IMAR) cell proliferation and on p210BCR/ABL expression.

Where p210BCR/ABL chimeric protein is considered to be implicated in the pathogenesis of Philadelphia chromosome-positive human leukemias.

Injection of CCL extract showed to inhibit the cell viability of both K562 CML human cell line and K562 IMAR, according to the MTT assay.

In protein implication, cynaropicrin and its deacyl derivative from the CCL extract displayed a significant capability in the inhibition of the p210BCR/ABL oncoprotein, according to the Western blot technique.

In cancer viability assay, CCL extracts exerted a similar effect compared to that of imatinib or its cancer growth arrest in CML.

In the depth differentiation, researchers also found that CCL extract also showed strong inhibition of the delay or overcome the resistance of CML to chemotherapy.

Taken altogether, artichoke with the abundantly bioactive compounds may be considered a functional remedy for the prevention and treatment of chronic myeloid leukemia with no side effects, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1)Biochemical and chemical characterization of Cynara cardunculus L. extract and its potential use as co-adjuvant therapy of chronic myeloid leukemia by Russo A1, Perri M1, Cione E1, Di Gioia ML1, Nardi M1, Cristina Caroleo M. (PubMed)

Honey Protects the Neurons Integrity Against Neuro-Degeneration

By Kyle J. Norton

Neurodegeneration is a process characterized by the progressive loss of the functions of brain cells, caused by the damage of structure or health of neurons.

Some researchers suggested that neurodegenerative diseases found mostly in the aging population are a gradual and irreversible neuronal damage and death affected by a common final pathway due to aging,

There are numbers of neurodegenerative disease associated with neurodegeneration, including amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, and Huntington's disease.

The causes of neurodegeneration are unclear. Many risk factors were found to influence the risk of disease, including gender, endocrine conditions, oxidative stress, infection and inflammation, nutrition, vascular conditions, depression, head trauma, tumors, and level of education.

However, some researchers suggested that excessive alcohol consumption that leads to a severe loss in the frontal cortex due to oxidative stress may be the most of common factors associated with the onset of the diseases, other than aging.

Dr. Fulton T, the lead scientist in the investigated neurodegeneration in excessive alcohol consumption, wrote, "Neuroimmune gene induction by binge drinking increases neurodegeneration through increased oxidative stress, particularly NADPH oxidase-induced oxidative stress".

And, "Adolescence is a period of high risk for ethanol-induced neurodegeneration and alterations in brain structure, gene expression, and maturation of adult phenotypes".

Where NADPH oxidases are the major sources of reactive oxygen species found in cardiovascular, neural, and kidney cells.

The results strongly suggested if you have a binge drink habit, you may be at the substantially higher risk of early onset of neurodegeneration.

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

In the urgency to discover a natural compound with the potential of treating a neurodegenerative disease, researchers examined the Malaysian Tualang Honey (TH), an antioxidant agent, in the cerebral cortex of rats against KA-induced oxidative stress and neurodegeneration.

The study included Male Sprague-Dawley rats randomly divided into five groups: control, KA-treated group, TH + KA-treated group, aspirin (ASP; anti-inflammatory agent) + KA-treated group and topiramate (TPM; antiepileptic agent) + KA-treated group.

The animals were pretreated orally with drinking water, TH (1.0g/kg BW), ASP (7.5mg/kg BW) or TPM (40mg/kg BW), respectively, five times at 12 h intervals. KA (15mg/kg BW) was injected subcutaneously 30 min after last treatment to all groups except the control group (normal saline).

Compared to the control, KA injection rats group showed a significantly neuronal degeneration in the piriform cortex and heightened the predilection to seizures.

TH pretreatment inhibited the KA-induced neuronal degeneration in the piriform cortex but failed to prevent the occurrence of KA-induced seizures.

TH pretreatment also exerted a strong effect in increasing locomotor activity and reducing hyperactivity in OFT, KA-induced animals.

Furthermore, HT pretreatment improved the antioxidant enzymes produced by the host and decreased the levels of thiobarbituric acid reactive substances.

The results suggested that HT protects the integrity of the neurons against overexpression of ROS through its antioxidant activity.

Taken altogether, Malaysian Tualang Honey (TH) may be considered a functional remedy for the protection of neuron integrity against the onset of neurodegeneration, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effect of tualang honey against KA-induced oxidative stress and neurodegeneration in the cortex of rats by Mohd Sairazi NS1, K N S S2, Asari MA3, Mummedy S1, Muzaimi M4, Sulaiman SA. (PubMed)
(2) Neuroimmune Signaling in Drug Actions and Addictions by Fulton T. Crews, Ryan P. Vetreno, in International Review of Neurobiology, 2014. (Science Direct)