Herbal Ginger, the Potential Dietary Antioxidant, Scientists Find

By Kyle J. Norton


Antioxidants are stable atoms which inhibit oxidation. Antioxidants in our body are either produced by the host or dietary intake.

The aim of antioxidants is to balance the levels of free radicals. Free radicals are highly unstable atoms with an unpaired electron in the outermost ring. Therefore, in order for them to become stable, free radical is ready to donate or intercept an electron from another atom, leading a chain reaction that can not be stopped until all electrons in the outermost ring are paired or inhibited by antioxidants.

This chain of domino's effect can lead to overexpression of free radicals or oxidative stress, the major cause of proteins, lipid and cells damage in the initiation of several chronic ailments, such as cancers.

Free radicals can be generated from the air we breathe, the foods we eat. In other words, any chemicals containing oxygen atoms can cause the development of free radicals.

Internally, free radicals are produced by cells metabolism in the generation of energy for body needs.

In a healthy individual, free radical is always balanced by the antioxidants enzymes produced by the host and dietary antioxidants.

In an aging population, decreased the production of antioxidant enzymes accompanied with the weakened of the immune system is worrisome, as overexpression free radical can cause a buildup of damaged proteins and other molecules that can be toxic to cells.

Therefore, change of lifestyle by eating healthy foods with high antioxidants and moderate exercise may be necessary for the elderly to reduce the negative effect of free radicals overexpression.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers in the concern of abnormal metabolism that leads to the increase of reactive oxygen species (ROS) production in the initiation of cancer examined the ginger antioxidant activity.

The study included 2 types of kombucha tea with or without ginger administered to BALB/c mice before and after inducing breast tumor.

Administration of kombucha ginger tea showed a significantly decreased catalase activity which has been found to induce production of free radicals and the levels of antioxidant produced by the tumor.

Markerly, the kombucha ginger tea also decreased Malondialdehyde (MDA) level in tumor homogenate.

The results suggested that ginger inhibited tumor cell expression through antioxidant effects.

Dr. said, " The consumption of kombucha prepared from ginger could exert minor antioxidant impacts by balancing multi-antioxidant factors in different tissues in the breast cancer models".

In order to reveal additional information about the ginger antioxidant activity, researchers examined a ginger extract (GE) against lipid oxidation.

GE and the constituent components showed to exhibit antioxidant properties associated with their hydroxyl groups and suitable solubilizing side chains.

Interestingly, 6-Shogaol and 10-gingerol exhibited higher antioxidant activity at 60°C compared to 6-gingerol and 8-gingerol.

Overall, GE displayed the strongest dose-dependent antioxidant properties, especially at high temperatures, compared to its constituents.

Taken altogether, ginger may be considered a functional remedy for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Evaluation of the antioxidant impact of ginger-based kombucha on the murine breast cancer model by Salafzoon S1, Mahmoodzadeh Hosseini H2, Halabian R2. (PubMed)
(2) Antioxidant activities of ginger extract and its constituents toward lipids by Si W1, Chen YP2, Zhang J3, Chen ZY4, Chung HY. (PubMed)

Herbal Turmeric Protects the Arteries Against Acute Coronary Syndrome Developing

By Kyle J. Norton

Acute coronary syndrome is a medical emergency caused by suddenly reduced blood flow to the heart, leading to heart muscle damage and brain apoptosis depending on the affected location.

The acute coronary syndrome is associated with the severity of buildup of plaque deposits in and on the walls of the coronary arteries.

Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood.

Arteries formed a part of blood vessels and circulatory system with function to deliver oxygen and nutrients to heart muscles.

Depending on the severity of the blockage, a complete blockage is life-threatening. Symptoms of the acute coronary syndrome, chest pain or discomfort,  pain or discomfort in one or both arms, the jaw, neck, back or stomach, shortness of breath, dizziness, and nausea.

If the chest pain is persistent with no sign of stopping, please call 911 immediately.

Most common treatment of acute coronary syndrome is medicine to reopen the artery. However, in severe case, angioplasty (a inflate a small balloon) may be necessary.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential ingredient for the treatment of acute coronary syndrome, researchers examined whether, Curcuma Longa Radix (Huangsiyujin in Chinese, HSYJ) in the promotion of blood circulation and relieving pain.

According to the tested assays, five fractions (volatile oil fraction, petroleum ether fraction, ethyl acetate fraction, 1-butanol fraction and water fraction) showed efficacy in increased pain threshold, prolonged latency of twisting, decreased the writhing times and influenced hemorheology.

More precisely, the volatile oil fraction and ethyl acetate fraction showed much better efficacy compared to other fractions.

In other words, all constituents in curcumin worked synergistically for the promotion of blood circulation and relief of pain.

In order to know more information about the turmeric anti- acute coronary syndrome activity, researchers investigated whether curcumin processed the inhibition of platelet activation against coagulant and thrombotic effects.

Compared with the thrombin group, the curdione treatment was significantly down-regulated only 2 proteins (Talin1 and β1-tubulin) associated with the induction of platelet activation.

Additional examination suggested that curdione inhibits the expression of vinculin involved in focal adhesion plaques and Talin1 by β1-tubulin involved in platelet activation that affect the integrin signaling pathway in stimulating the coagulant and thrombotic effects.

Taken altogether, turmeric may be considered supplements for the prevention and treatment of acute coronary syndrome, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Screening of active fractions from Curcuma Longa Radix isolated by HPLC and GC-MS for promotion of blood circulation and relief of pain by Chen Z1, Quan L2, Zhou H2, Zhao Y2, Chen P2, Hu L2, Yang Z2, Hu C3, Cao D. (PubMed)
(2) Curdione attenuates thrombin-induced human platelet activation: β1-tubulin as a potential therapeutic target by Zhang D1, Qiao W1, Zhao Y2, Fang H2, Xu D2, Xia Q. (PubMed)

Bromelain Improves All Parameters Associated with Osteoarthritis in Human Trials

By Kyle J. Norton

Osteoarthritis (OA), a type of musculoskeletal disorders associated with the wear and tear on a joint, found mostly in the aging population.

In other words, OA occurs when the protective cartilage on the ends of the bones wears down over time.
According to the statistics, osteoarthritis affects over 25 million people in the United States.

Because of its far higher prevalence due to aging and obesity, OA has become a significant economic burden to the US.

Believe it or not, approximately 1/3 of direct OA expenditures are allocated for medications, including pain medications accompanied by the 50% spent on hospitalization costs.

Most common symptoms of OA are the pain, tenderness, stiffness, and loss of flexibility of the joint, during or after movement. 

Some patients may also experience symptoms of grating sensation, bone spur and hard lumps developed around the affected joint.

Other risk factors, besides aging and obesity, are a genetic preposition, gender, joint injury that did not heal properly, bone deforms and occupation that requires repetitive use of the joint.

Dr. Keith T Palmer wrote, "Reasonably good evidence exists that physical work activities (especially kneeling, squatting, lifting, and climbing) can cause and/or aggravate knee OA. These exposures should be reduced where possible. Obese workers with such exposures are at additional risk of knee OA and should therefore particularly be encouraged to lose weight".

And, "This common chronic disease (OA) of older life causes significant disability and impaired quality of life, and its development often heralds a material reduction in a patient’s capacity to undertake daily activities, including their ability to work".

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a potential compound for the treatment of osteoarthritis, researchers investigated the effectiveness of oral bromelain, trypsin, rutoside trihydrate enzymes and diclofenac sodium combination therapy over diclofenac sodium for the treatment of TMJ osteoarthritis.

30 patients selected to the study were randomly divided into three groups with 10 patients treated with diclofenac sodium (Group 1), 10 given oral enzymes (bromelain, trypsin, rutoside trihydrate) and diclofenac sodium combination (Group 2), and the other 10 treated with oral enzyme preparation (bromelain, trypsin, rutoside trihydrate) (Group 3).

According to the evaluation on day 1, day 4, day 7 and day 10, group 2 patients responded better than group 1 and 3, particularly in pain management.

There is no significant difference between group 1 and group 3.

Based on the finding, researchers wrote, "The trial showed significant improvement in reducing pain in patients treated with oral enzymes and diclofenac sodium combination therapy".

Also, in order to know more information about bromelain anti-OA, efficacy researchers examined the treatment with bromelain containing enzyme preparation for 3-4 weeks on patients with knee osteoarthritis (OA).

The randomized, single-blind, active-controlled pilot study included 40 knees OA patients were randomized to receive oral bromelain (500 mg/day) or diclofenac (100 mg/day).

In WOMAC and SF-36 scores, bromelain exerted an improvement of total WOMAC and pain subscales similar to those of diclofenac. However, 2 patients in the diclofenac discontinued the study due to adverse effects.

At week 16, bromelain treatment group demonstrated an improvement of total WOMAC scores (12.2 versus 25.5), pain subscales (2.4 versus 5.6), stiffness subscales (0.8 versus 2.0), and function subscales (9.1 versus 17.9), and physical component of SF-36 (73.3 versus 65.4) as compared to the baseline.

Additionally, levels of pro-inflammatory cytokines and oxidative stress markers also inhibited at week 16 compared to control.

Taken altogether, bromelain may be considered supplements for the prevention and treatment of OA, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Efficacy of Bromelain along with Trypsin, Rutoside Trihydrate Enzymes and Diclofenac Sodium Combination Therapy for the treatment of TMJ Osteoarthritis - A Randomised Clinical Trial by Jayachandran S1, Khobre P. (PubMed)
(2) Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis by Kasemsuk T1, Saengpetch N2, Sibmooh N1, Unchern S. (PubMed)
(3) Occupational activities and osteoarthritis of the knee by Keith T Palmer. (PMC)

Whole Food Honey, A Natural Treatment of Chronic Foot Ulcers with No Side Effects

By Kyle J. Norton


A chronic leg ulcer is a medical condition caused by the defect in the skin below the level of the knee that does not heal and lasts more than six weeks.

Most common causes of chronic foot ulcer are venous disease induced the onset of edema and the eventual breakdown of tissues due to lack of oxygen and nutrients.caused by the accumulation of the plaque on the arterial walls and neuropathy that affects the autonomic, sensory and motor components of the nervous system.

However, in patients with diabetes, chronic foot ulcers are one of the most significant and devastating complications and a leading risk of amputation.

Besides medical condition indicated above, cigarette smoking has been found to increase the risk of chronic foot ulcers.

Dr. Jodi C. McDaniel, the lead scientists in the differentiation of smoking risk in patients with chronic wound said, "Evidence-based guidelines for treating venous leg ulcers, diabetic foot ulcers, and pressure ulcers, the 3 main categories of chronic wounds, focus primarily on biologic therapies". 

And "However, there are also evidence-based guidelines for treating behavioral risks to poor healing, such as smoking, which should be incorporated into treatment plans when appropriate".

The findings strongly suggested, if you are cigarette smokers, your risk of a chronic foot ulcer increases substantially.

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy food for replacing the use of white sugar and artificial sweetener by many people.

With an aim to find a natural ingredient for the prevention and treatment of chronic foot ulcers in diabetics, researchers launched an exhaustive literature search in PUBMED, COCHRANE, GOOGLE using keywords 'topical honey', 'diabetic foot ulcer', 'chronic wounds'.

5 clinical trials and about 10 observational studies in various parts of the world satisfied the standard criteria and guideline were included in the review.

According to the 3 selected clinical trials, the honey dressing was better than conventional dressing, all the clinical trials proved the safety of honey for the treatment of diabetic foot ulcer. 

Furthermore, in order to know more information about honey in the treatment of chronic leg ulcer, researchers investigated the healing of chronic venous leg ulcers (CVLU) using medical grade honey comparable to that of standard wound therapy.

According to 299 papers were identified, five represented the best evidence available to answer the clinical question.

According to 2 selected trials, one showed better outcomes for CVLU healing with the use of honey over standard wound therapy and the other showed equivalent outcomes but more adverse effects.

Another study suggested that a third randomized controlled trial showed a non-signific ant reduction in bacterial colonization of CVLU with honey compared to standard therapy. 

Taken altogether, honey may be considered a functional remedy for the treatment of chronic foot ulcers in diabetics, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Topical honey for the treatment of diabetic foot ulcer: A systematic review by Kateel R1, Adhikari P2, Augustine AJ3, Ullal S. (PubMed)
(2) Medical grade honey in the management of chronic venous leg ulcers by Holland LC1, Norris JM. (PubMed)
(3) Smoking, Chronic Wound Healing, and Implications for Evidence-Based Practic by Jodi C. McDaniel, Ph.D., RN, Assistant Professor, and Kristine K. Browning, Ph.D., Assistant Professor. (PMC)

Tomatoes Protect the Liver Against Non-alcoholic Steatohepatitis in Vivo

By Kyle J. Norton

Nonalcoholic steatohepatitis (NASH) is a type of inflammatory non-alcoholic fatty liver disease caused by excessive fat accumulated in the liver.

Nonalcoholic steatohepatitis (NASH) is asymptomatic until the condition is developed into cirrhosis, the condition that causes advanced liver scars and reduced the performance of the liver.

In other words, if more than 5% – 10% percent of your liver’s weight is fat, you have a fatty liver (steatosis).

According to the statistics, non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of liver disease affecting 100 million people in the US. Out of that number, approximately 20% of people have NASH.

Medical conditions such as obesity, metabolic syndrome, and type 2 diabetes are some of the metabolic risk factors that have been found to induce the development of NASH.

As of today, there is no effective treatment of NASH. Depending on the condition people with overweight or obese are recommended to lose weight. The aim of medical treatment is to reduce the symptoms and delay the progression of the condition and improve the quality of life.

Out of many prevalent factors that cause the onset of NASH, some researchers suggested that the promotion of high-fat diet over the past few decades induced high percentage of the overweight and obese population may be the major culprit associated with the rise of NASH.

Dr. Jensen VS, the lead scientist wrote, "Hepatic dysfunction and inflammation was confirmed in HFD-fed rats by elevated levels of hepatic MCP-1 (p < 0.0001), TNF-alpha (p < 0.001) and plasma β-hydroxybutyrate (p < 0.0001), and in NASH-fed rats by elevated levels of hepatic MCP-1 (p < 0.01), increased hepatic macrophage infiltration (p < 0.001), and higher plasma levels of alanine aminotransferase (p < 0.0001) aspartate aminotransferase (p < 0.05), haptoglobin (p < 0.001) and TIMP-1 (p < 0.01) compared to Control".

And, " dietary fat and cholesterol are the primary drivers of NAFLD development and progression in rats, while fructose mostly exerts its effect on the circulating lipid pool".

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

With an aim to discover a potential and natural compound for the treatment of liver cancer, researchers in the cancer tram at the First Affiliated Hospital of Harbin Medical University examined the hepatoprotective effect of lycopene (Ly) on the non-alcoholic fatty liver disease (NAFLD) in an animal model.

65 rats selected to the study were randomly divided into the normal group, model group, and lycopene (Ly) treatment groups, with model rats induced NAFLD by feeding a high-fat diet for 14 wks.

Pretreatment of lycopene at the dose of 20 mg/kg showed a significant decrease in the levels of serum AST (2.07-fold), ALT (2.95-fold), and the blood lipid TG (2.34-fold) and TC (1.66-fold) compared to the model group.

Furthermore, pretreatment with 5, 10 and 20 mg/kg of Ly significantly raised the levels of antioxidant enzyme SOD in a dose-dependent manner compared to the model group. 

Additional differentiation of the lycopene liver protective property, researchers found that Ly not only significantly decreased levels of lipid products LDL-C and improved HDL-C level but also significantly decreased the content of liver free fatty acid (FFA), also compared to the model group.

Moreover, in the doses of pretreatment with 5, 10 and 20 mg/kg of Ly also significantly reduced MDA amount, a marker of liver oxidative stress by 30.87, 45.51 and 54.49% in the liver homogenates, respectively

Levels of CYP2E1 expression associated with the metabolism of xenobiotics in the liver, proinflammatory cytokines, infiltration of liver fats and reversed histopathological changes in the model group also were reduced by the injection of Ly.

Based on the results, researchers said, "Ly has a protective effect on NAFLD, down-regulates expression of TNF-α, and that CYP2E1 may be one of the action mechanisms for Ly".

Taken altogether, tomatoes processed abundantly bioactive compound Ly may be considered supplements for the prevention and treatment of non-alcoholic steatohepatitis through its liver protective, anti-inflammatory, and antioxidant properties, pending to the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
non-alcoholic steatohepatitis
(1) Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liverdisease in rat by Jiang W1, Guo MH1, Hai X. (PubMed)
(2) Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation by Aizawa K1,2, Liu C1, Tang S1, Veeramachaneni S1, Hu KQ1, Smith DE3, Wang XD. (PubMed)
(3) Dietary fat stimulates development of NAFLD more potently than dietary fructose in Sprague-Dawley rats by Jensen VS1,2, Hvid H2, Damgaard J2, Nygaard H2, Ingvorsen C3, Wulff EM4, Lykkesfeldt J1, Fledelius C. (PubMed)

Turmeric Protects the Stomach Against Gastric Ulcer Developing

By Kyle J. Norton

Gastric or stomach ulcer is a condition of localized tissue erosion in the lining the stomach.

Most common symptoms of gastric ulcer are abdominal pain, bloating, septic shock, dyspepsia, and blood in the stool due to bleeding,  unintended weight loss and loss of appetite and gastrointestinal discomforts.

Some patients may also experience symptoms of mood disorder, leading to reduced quality of life in many patients.

The imbalance between stomach acid and upper GI tract mucosa are the main cause of the condition onset associated with the use of certain medication, including aspirin, and non-steroidal anti-inflammatory drugs, Helicobacter pylori infection and chronic gastritis.

Epidemiologically, periodontal disease, aging, smoking, long-term use of mechanical ventilation and critical illness are at an increased risk of gastric ulcer.

According to studies gastric ulcer can be preventable, you  can protect yourself against the risk gastric ulcer by

1. Adding dietary phytosterols and phospholipids
Experiments using animal peptic ulcer models showed that the lipid fraction in foods from the staple diets of low prevalence areas gave protection against both gastric and duodenal ulceration, including ulceration due to non-steroidal anti-inflammatory drugs (NSAIDs), and also promoted healing of ulceration. 

2. Reducing intake of NSAID
As NSAID has been proven to cause gastric Ulcer(9), by inhibiting the body’s production of prostaglandins, hormones that protect the stomach lining.

3. Quitting smoking
Cigarette smoking increases xanthine oxidase activity, leukotrienes, and nitric oxide production and also neutrophil infiltration in the gastric mucosa(13).

4. Not missing your dental appointment
The study showed that a significantly higher proportion of subjects with peptic ulcer reported that they lost five or more teeth (35.3 vs. 17.4%, p&lt;0.001) or that they were told they had periodontitis (33.5 vs. 20.7%, p&lt;0.001)(8).

5. Reducing stress

Stress had been found to increase the onset of gastric ulcer in people who suffered from the Great East Japan earthquake and tsunami.  The incidence of all types of peptic ulcers was 1.5-fold increased after the earthquake.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural compound for the treatment of gastric ulcer, researchers examined the intact (TrPP) and modified, and the low-molecular-weight (MTrPP) forms of pectic polysaccharides isolated from turmeric against a gastric ulcer in vitro and in vivo models.

Compared to TrPP, MTrPP possessed a significantly better ulcer-preventive property by inhibiting ulcer scores up to 85%.

More precisely, MTrPP exerted an effective muco-protection, inhibited the expression of H(+), K(+)-ATPase in the ulcer forming and of H. pylori growth/adherence, higher antioxidant/cytoprotective mechanisms associated to the gastric lesion.

By comparing the chemical contents in TrPP, and MTrPP, researchers suggested that the efficacy of MTrPP in the protection against the formation of the gastric ulcer may be attributed to the levels of galacturonic acid (687mg/g; TrPP-544mg/g) and galactose (52.9%; TrPP-21.7%) in the inhibition of inflammation.

In other words, the low molecular weight of MTrPP (155kDa; TrPP-13kDa) possesses higher antiulcer potential compared to that of TrPP.

In order to reveal more information about turmeric anti-gastric ulcer activity, researchers evaluated the effect of C. Angustifolia and M. arundinacea on forced swimming-induced hypothermia and gastric ulceration in rats.

According to the observation of 72 hours periodically and mortality recorded up to seven days, application of both drugs did not produce any toxic symptoms or mortality even up to the maximum dose level of 4400 mg/kg.

Both the test drugs showed a significantly reversed the stress-induced gastric ulceration compared to stress-control rats.

Taken altogether, curcumin used in the intact (TrPP) and modified, and the low-molecular-weight (MTrPP) forms may be considered a remedy for the prevention and treatment of gastric ulcer, pending to large sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Modified pectic polysaccharide from turmeric (Curcuma longa): A potent dietary component against gastric ulcer by Harsha MR1, Chandra Prakash SV1, Dharmesh SM. (PubMed)
(2) Evaluation of acute toxicity and anti-ulcerogenic study of rhizome starch of two source plants of by Tugaksheeree (Curcuma angustifolia Roxb. and Maranta arundinacea Linn.).
Rajashekhara N1, Ashok BK2, Sharma PP3, Ravishankar B. (PubMed)
(3) Gastric Ulcers: Preventions – The do and do not’s list by Kyle J. Norton

Herbal Bilberry Inhibits Diseases Associated with Mitochondrial Dysfunction

By Kyle J. Norton


Mitochondrial dysfunction is a condition affecting the organelles that generate energy for the cell.

Mitochondria are the cell that converts the food molecules into the energy for the body tissues needs. Mitochondria produce 90 percent of the energy for the body function.

The genetic proposition has been found to alter the process of mitochondria in converting oxygen and food to energy in some people. Acquired mitochondrial dysfunction has been found in patients with Alzheimer’s disease, muscular dystrophy, Lou Gehrig’s disease, diabetes, and cancer. 

Most common symptoms of mitochondrial dysfunction include poor growth
muscle weakness, muscle pain, low muscle tone, exercise intolerance, vision and/or hearing problems
learning disabilities, delays in development, mental retardation depending on the location of the infected cells.

Diseases associated with mitochondrial dysfunction include Autism, autism-like features Heart, liver or kidney diseases, gastrointestinal disorders, diabetes, neurological problems, thyroid and respiratory (breathing) problems and dementia.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belongings to the family Ericaceae, native to Northern Europe.

The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

With an aim to find a potential ingredient for the treatment of mitochondrial dysfunction associated with common symptoms found in almost every chronic disease, researchers examined the effect of berries of bilberry and black currant with a rich source of anthocyanin on nonalcoholic steatohepatitis (NASH).

In an animal model selected to the study induced NASH by a methionine-choline-deficient (MCD) diet in mice, oral administration berries of bilberry and black currant alleviated inflammation, oxidative stress, steatosis, and even fibrosis.

Furthermore, berries of bilberry and black currant improved depletion of mitochondrial content and damage of mitochondrial biogenesis and electron transfer chain developed concomitantly in the liver of mice fed with the MCD diet-induced mitochondrial dysfunction.

Moreover, anthocyanins treatment improved the mitochondria by promoting the activation of proteins associated with cellular energy homeostasis,(AMP-activated protein kinase (AMPK)) and energy metabolism (peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α)).

Dr. Tang X, the lead scientists said, "These data provide evidence that anthocyanins possess significant protective effects against NASH and mitochondrial defects in response to an MCD diet".

Additionally, on liver damage in restraint-stressed mice, similar to that of the aforementioned study, bilberry extract restored ALT and ROS to normal levels and enhanced mitochondrial complex II activity that was lowered in restraint-stressed mice.

Genes expression related to mitochondrial electron transfer chain (ETC)-and mitochondria membrane potential were also improved substantially.

In other words, bilberry extract exhibited a protective effect by scavenging free radicals and attenuating mitochondrial dysfunction in the liver of restraint-stressed mice.

Taken altogether, bilberry processed abundantly bioactive compound anthocyanoside may be considered a functioning remedy for the prevention and treatment of mitochondrial dysfunction, pending to the validation of larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Purified anthocyanins from bilberry and black currant attenuate hepatic mitochondrial dysfunction and steatohepatitis in mice with methionine and choline deficiency by Tang X1, Shen T, Jiang X, Xia M, Sun X, Guo H, Ling W. (PubMed)
(2) Bilberry extracts protect restraint stress-induced liver damage through attenuating mitochondrial dysfunction by Bao L1, Abe K, Tsang P, Xu JK, Yao XS, Liu HW, Kurihara H. (PubMed)