Phytochemical 3,3'-Diindolylmethane, the Potential Anti Colorectal Cancer Phytochemicals With No Side Effects, Researchers Find

By Kyle J. Norton 

3,3'-Diindolylmethane or DIM may be used as a bioactive compound for the treatment of colorectal cancer with no side effects, according to studies.

Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of cells DNA.

According to the statistics provided by the American Cancer Society, in the US, colorectal cancer is the third most common cancer diagnosed in both men and women compared to other types of cancer.

The lifetime risk of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

Approximately, 140,000 cases of colorectal cancer were diagnosed in the US in 2018. The cancer also causes of death of over 50, 000 people, representing 8.3% of total cancer death.

Being overweight or obese. smoking, physical inactivity, excessive alcohol drinking, the increased in age,  family and personal history, genetic preposition are some of the prevalent risks of the disease.

Some researchers suggested that unhealthy diet such as the promotion of the Western diet over the past few decades may be one of the major causes of colorectal cancer.

Dr. Alan Moss, the lead scientist in the evaluation of the association of between diet and colorectal cancer risk, wrote, "Studies that examined dietary factors and various cancers showed that one of the strongest associations is between CRC and meat consumption"

And "Recently, global publicity was generated by the World Health Organization International Agency for Research on Cancer consensus statement regarding the increased risk of CRC with consumption of processed or red meat.4 The 2015 statement notes that processed meat is carcinogenic to humans and lists processed meat as a group 1 substance. Processed meats result from salting, smoking, fermenting, or curing the meat, and common examples include ham, bacon, and sausage".

The results clearly suggested that by changing your diet pattern from the Western diet to a traditional diet with high fruits and vegetables, your risk colorectal can be reduced substantially.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

Researchers in the concern of the slow growth of colorectal cancer and the prognosis in colorectal cancer patients examined the effects of 3,3'-Diindolylmethane (DIM) on cyclin D1, which was aberrantly overexpressed in colorectal cancer cells and tumors.

Where cyclin D1 is a protein needed for cellular proliferation in the G1 phase of the cell cycle.

Injection of DIM inhibited the cyclin D1 expression in colorectal cancer cells (CRC), without affecting the PPARγ expression and protease activity in regulating the process of cell differentiation.

Moreover, DIM inhibition of the cell cycle in the G1 phase of colorectal cancer cells (CRC) without alternating the cyclin D1 mRNA expression. The results suggested DIM modulated cyclin D1 expression at the translational level through some unknown mechanisms.

Dr. Zhang X and colleagues wrote in the final report, "the present study demonstrates that DIM downregulates cyclin D1 through triggering ER stress in human colorectal cancer cells".

In other words, DIM-induced cell cycle arrest of the colorectal cancer cells by modulating the G1 phase of the cell cycle.

Additionally, in order to reveal more information about the DIM anti-colorectal cancer activity, researchers elucidated the molecular mechanism of ATF3 induction by DIM in human CRC cells. 

The DIM treatment induced apoptosis and induced ATF3 gene expression at protein and messenger RNA levels, involving the DNA repair of the damaged cells.

However, in colorectal cancer cells, deletion and point mutation of the ATF binding site (-23 to -16) abolished ATF3 promoter activation by DIM, leading to overexpression of ATF4 associated with the promotion metabolic homeostasis and cancer cell survival

In other words, DIM stimulates ATF3 expression in inducing apoptosis in human colorectal cells through inhibiting the ATF4-mediated pathway.

Taken altogether, 3,3'-Diindolylmethane derived from I3C may be considered a supplement for the prevention and combined with primary therapy for the treatment of colorectal cancer, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3,3'-diindolylmethane downregulates cyclin D1 through triggering endoplasmic reticulum stress in colorectal cancer cells by Zhang X1, Sukamporn P2, Zhang S3, Min KW4, Baek SJ. (PubMed)
(2) 3,3'-diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells by Lee SH1, Min KW, Zhang X, Baek SJ. (PubMed)
(3) The Association Between Diet and Colorectal Cancer Risk: Moving Beyond Generalizations
Alan Moss, and Kumanan Nalankilli. (Gastroenterology)

Artichoke In the Promotion of Digestive Health

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have a herbal remedy for improvement of digestive health, according to studies.

The digestive system is an organ consists of the gastrointestinal tract and other organs associated with digestive functioning including the salivary glands, pancreas, liver, and gallbladder.

Digestion is a process of breaking down foods into a smaller and smaller portion that can be absorbed and assimilated into the body.

Digestive disorders can be caused by the digestive problem or some underlying diseases, including GERD, IBS,...

Most common symptoms of digestive disorders include bloating, constipation, diarrhea, heartburn. fecal incontinence.and pain in the belly.

Although there are many risk factors associated with the onset of digestive problems, some researchers suggested that the promotion of the Western diet may have a strong implication in the induction of digestive disorders.

Dr. Marit K. Zinöcker, the lead scientist in the investigation of the Western diet and Microbiome wrote, "the Western diet promotes inflammation that arises from both structural and behavioral changes in the resident microbiome".

And, " The environment created in the gut by ultra-processed foods, a hallmark of the Western diet, is an evolutionarily unique selection ground for microbes that can promote diverse forms of inflammatory disease".

The findings clearly explained the negative impact of the Western diet in the alternation of the ratio of gut microbes, leading to digestive disorders in the initiation of chronic diseases.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Scientists on finding a natural remedy for the improvement of digestive function examined whether the consumption of artichokes enriched with a probiotic Lactobacillus paracasei strain affects fecal microbiota composition and other symptoms associated with chronic constipation.

The study included 8 volunteers (3M/5F age 40+/-14 y) integrated their normal diet with artichokes (180 gr) enriched with 20 billions of L. paracasei LMGP22043.

According to tested assays, additional artichoke diet exerted a strong effect in promotion of the colonized by the probiotic strain in all volunteers' gut, after 15 days of feeding.

Injection of artichoke also demonstrated a significant increase of butyric and valeric acids with a decrease of lactic acid, the indications of improvement of gut microbiota.

The diet integrated with artichoke also resolved the constipation symptoms by reducing the fecal beta-glucuronidase activity.

Interestingly, according to the analysis of symptom profile, there was a marked reduction in abdominal distension and feeling of incomplete evacuation in volunteers with constipation problems.

The results suggested that included artichoke in a diet promotes a healthy digestive system by balancing the ratio of gut microbiota.

In order to reveal more information about artichoke enhanced the function of the gastrointestinal tract, researchers investigated the effects of Jerusalem artichoke inulin (JA) or chicory inulin (CH) in snack bars on composition fecal microbiota, the concentration of fecal SCFA, bowel habit and gastrointestinal symptoms.

45 volunteers were selected to a double-blind, randomized, placebo-controlled, parallel-group study.

After a 7 days run-in period, subjects were randomly assigned to three groups of fifteen subjects each, consuming either snack bars with CH or JA, or snack bars without fructans (placebo); for 7 d (adaptation period), they ingested one snack bar per day (7.7 g fructan/d) and continued for 14 d with two snack bars per day.

At the end of the intervention, consumption of CH or JA improved the ratio of gut microbiota by increasing the counts of good bacterias such as bifidobacteria (+1.2 log10 in 21 d) and decreasing the counts of bad bacteria such as Bacteroides/Prevotella and Clostridium histolyticum/C. lituseburense group in frequency.

Consumption of CH or JA also resulted in mild and moderate flatulence in a few subjects compared to placebo with a slight effected of tool consistency.

Dr. Kleessen B, the lead scientist said, "...adaptation on increased doses of CH or JA in bakery products stimulates the growth of bifidobacteria and may contribute to the suppression of potentially pathogenic bacteria".

Taken altogether, artichoke alone and combined with other herbal remedies may be considered functional remedies for the treatment of the digestive disorder, pending to the confirmation of larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effects of probiotic Lactobacillus paracasei-enriched artichokes on constipated patients: a pilot study by Valerio F1, Russo F, de Candia S, Riezzo G, Orlando A, Lonigro SL, Lavermicocca P. (PubMed)
(2) Jerusalem artichoke and chicory inulin in bakery products affect faecal microbiota of healthy volunteers by Kleessen B1, Schwarz S, Boehm A, Fuhrmann H, Richter A, Henle T, Krueger M.(PubMed)
(3) The Western Diet-Microbiome-Host Interaction and Its Role in Metabolic Disease by Zinöcker MK1, Lindseth IA. (PubMed)

Ginger, A Natural Treatment for Parkinson disease (PD) with No Side Effects

By Kyle J. Norton

Scientists may have found a natural compound for the treatment of Parkinson disease (PD) with no side effects, according to studies.


Parkinson disease (PD) is a disabling, progressive condition caused by the gradual loss of neurons cells.

In other words, PD is a cognitive deficit associated with the interruption of frontal-subcortical loops that facilitate cognition and parallel the motor loop and loss of substantia nigra pars compacta (SNc) dopamine (DA) neurons.

According to the statistics, more than 10 million people worldwide are living with PD. In the US, every year, 60,000 adults are diagnosed with PD. Approximately, over 95% of people diagnosed with PD are over 50 years of age.

PD can be classified into 5 stages, depending on the severity

* Stage 1

In stage 1, symptoms of PD do not interfere with daily activities.

* Stage 2

In stage 2, the symptoms start to get worse over time. Making living alone to carry daily task now may be difficult.

* Stage 3

The symptoms are now interfering with daily activity, including the impairment of dressing and eating.

* Stage 4
The symptoms are severe with limited functioning, Patients in this stage have required the help of others to carry out daily activity.

* Stage 5, the most advanced stage of PD. Around-the-clock care is required for all activities. 

The exact causes of PD are unidentified. However, the epidemiological study suggested that age and sex, genetic factors, head trauma, exposure to chemicals, long-term use of certain medications and drugs are some of the prevalent risks of Parkinson disease (PD).

Some researchers suggested lifelong cigarette smoking may have a strong impact on the risk of PD.

Dr. Chaoran Ma, the lead scientist wrote, "Evidence from epidemiological studies suggest a relationship between cigarette smoking and low risk of Parkinson disease (PD). As a major component of tobacco smoke, nicotine has been proposed to be a substance for preventing against PD risk, with a key role in regulating striatal activity and behaviors mediated through the dopaminergic system".

And, "Animal studies also showed that nicotine could modulate dopamine transmission and reduce levodopa-induced dyskinesias".

The results strongly suggested that if you smoke, your risk of PD is increased substantially compared to never smoke healthy adults.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers in the concern about Parkinson's disease (PD) associated with the progressive degeneration of dopaminergic neurons in the nigrostriatal system and dopamine (DA) depletion in the striatum, examined the Zingerone and eugenol, essential oils extracted from ginger and cloves, free radical scavenging and antioxidant effects.

Rodents used in the study were induced PD by injected with 6-hydroxydopamine (6-OHDA) intracerebroventricularly.

According to the assays, daily oral administration of eugenol/zingerone and injection of L-DOPA intraperitoneally for 4 weeks following a single 6-OHDA injection did not improve abnormal behaviors induced by L-DOPA treatment.

Where 3-(3,4-Dihydroxyphenyl)-L-alanine (L-DOPA) is the most popular therapeutic medicine for treating PD with adverse effects.

However, injection of zingerone and eugenol alone enhanced the reduction of striatal DA and its metabolites and zingerone decreased the oxidative stress and increased the levels of antioxidants such as glutathione peroxidase and the oxidized L-ascorbate in the striatum.

In other words, compared to the effects of zingerone against PD through its antioxidant activity, pre-treatment with zingerone or eugenol do not prevent 6-OHDA-induced DA depression by preventing lipid peroxidation.

Taken altogether, ginger may be considered a functional spice for the prevention and treatment of PD, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Effects of zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] and eugenol [2-methoxy-4-(2-propenyl)phenol] on the pathological progress in the 6-hydroxydopamine-induced Parkinson's disease mouse model by Kabuto H1, Yamanushi TT. (PubMed)
(2) Nicotine from cigarette smoking and diet and Parkinson disease: a review by Chaoran Ma,1 Yesong Liu,2 Samantha Neumann,3 and Xiang Gao. (PMC)
(3) Stages of Parkinson's by Parkinson's Foundation

Honey, the Herbal Remedy Which Suppresses Osteoarthritis

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have a herbal remedy for the prevention and treatment of osteoarthritis, according to studies.

Osteoarthritis (OA) is a common chronic inflammatory joint disease characterized by the breaking down of joint cartilage and the underlying bone.

Genetic preposition, overweight, and obesity, injury, and overuse of the joints are the most common risk factor associated with the onset of the disease.

Occupation with the repetitive movements of the joint is most affected by the disease.

Interestingly, osteoarthritis symptoms can come and go throughout the day and vary from person to person. Weather change has been one of the most complaints that trigger the symptoms of OA in the elderly.

Most common symptoms, according to epidemiological studies include joint pain, tenderness, and lack of flexibility and stiffness.

Some osteoporotic patient may also experience symptoms of grating sensation and bone spurs.

If you experience some of the above symptoms, you may have osteoarthritis.

Some researchers suggested that obesity may be one of the major risk factors besides the occupation with repetitive movement of osteoarthritis in the Western world.

Dr. Lauren K. King, the lead scientists in the investigation of obesity & osteoarthritis, wrote, "The most significant impact of obesity on the musculoskeletal system is associated with osteoarthritis (OA), a disabling degenerative joint disorder characterized by pain, decreased mobility and negative impact on quality of life".

And, "Obesity is associated with the incidence and progression of OA of both weight-bearing and non-weight-bearing joints, to rate of joint replacements as well as operative complications".

The finding strongly indicated the risk of osteoarthritis is increased by many folds in the obese population, compared to those with a healthy weight.

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

In the concerns of widespread osteoarthritis (OA), a chronic degenerative joint disease, researchers investigated chrysin, a natural flavonoid extracted from honey and propolis anti-inflammatory effects.

The study included human OA chondrocytes pretreated with chrysin (1, 5, 10 μM) for 2 h and subsequently stimulated with IL-1β, an inflammatory cytokine for 24 h.

Injection of chrysin exerted a strong inhibition activity against the degradation of aggrecan and collagen-II.

Chrysin significantly inhibited the IL-1β-induced production inflammatory cytokines such as degradation of c of NO and PGE2; expression of COX-2, iNOS.

Futhermore, chrysin also reduced the expression of matrixes such as MMP-1, MMP-3, MMP-13 and enzymes ADAMTS-4, and ADAMTS-5 associated with the progression and destruction of joint in early osteoarthritis.

In the depth analysis researchers also found that chrysin dramatically blocked IL-1β-stimulated IκB-α degradation in the activation of protein NF-κB-induced production of proinflammatory cytokines.

The results suggested that chrysin inhibits the progression of OA through several mechanisms, including enzymes and proteins involving the destruction of joint tissues.

Taken altogether, honey processed a bioactive compound chrysin may be considered a functional remedy for the prevention and treatment of OA, with no side effects, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Chrysin Attenuates IL-1β-Induced Expression of Inflammatory Mediators by Suppressing NF-κB in Human Osteoarthritis Chondrocytes by Zheng W1, Tao Z1, Cai L1, Chen C1, Zhang C1, Wang Q1, Ying X1, Hu W1, Chen H2. (PubMed)
(2) Obesity & osteoarthritis by Lauren K. King,* Lyn March,** and Ananthila Anandacoomarasamy. (PMC)

Phytochemical 3,3'-Diindolylmethane Kills Pancreatic Cancer Cells in Vitro

By Kyle J. Norton

Scientists may have found a bioactive ingredient for the treatment of pancreatic cancer with no side effects, according to studies.

Pancreatic cancer is a medical condition characterized by irregular cell growth in the tissue of the pancreas.

Most cases of pancreatic cancer start in the cell on the surface of the inner lining of the pancreatic tissue, before penetrating into the deeper layers to form a large and invasive tumor.

At the early stage, patients with pancreatic cancer may be asymptomatic. However, at the later stage, besides the common symptoms shared by all types of cancer such as unintended weight loss, loss of appetite, fatigue and gastrointestinal discomforts, patients with the condition may also experience localized symptoms such as internal bleeding and severe pain due to the oversize tumor which suppresses the nerve cells and blood vessels.

According to the statistic, in the US, every year, approximately 55,440 adults (29,200 men and 26,240 women) are diagnosed with pancreatic cancer.

The 5-year survival rate including all stages of people with pancreatic cancer is 8%, compared to 32% of cancer detected at an early stage.

The exact causes of pancreatic cancer are identified. However, epidemiological studies suggested that the increase in age, family history, race, gender, smoking, being obese or overweight and a medical condition such as diabetes is a most prevalent risk of the disease.

Some researchers indicated that genetic preposition may have a strong implication in the initiation of the onset of pancreatic cancer.

Dr. Alison P. Klein wrote, "These consist of high penetrance genes including BRCA2 or PALB2, to more common genetic variation associated with a modest increase risk of pancreatic cancer such as genetic variation at the ABO blood group locus".

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

On finding a bioactive ingredient for the treatment of pancreatic cancer, researchers investigated the 3,3'-Diindolylmethane (DIM), ring-substituted DIMs and 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl) methanes (C-DIMs) against the growth of Panc-1 and Panc-28 pancreatic cancer cells.

According to assays, Both DIM and DIM-C-pPhtBu induced pancreatic cancer cells. apoptosis observed by the increased endoplasmic reticulum (ER) staining and ER calcium release in Panc-1 cells.

Glucose-regulated protein 78, a protein in the endoplasmic reticulum in the cell played an important role in cellular adaptation and oncogenic survival also increased by the injection of both DIM and DIM-C-pPhtBu.

Furthermore, both DIM and DIM-C-pPhtBu. also exerted a significant activity against the pancreatic cancer cells through increasing the C/EBP homologous transcription factor in the regulation of cells apoptosis in response to cellular oxidative stress, similar to those of thapsigargin (Tg).

Moreover, DIM/DIM-C-pPhtBu- and Tg-induced ER stress in facilitating the pancreatic cancer cells death through cell death receptors and proteins associated with programming cell death.

Dr. the lead scientists after taking into account co and confounders wrote in the final report, "Activation of both receptor-dependent and receptor-independent (ER stress) pathways by DIM and DIM-C-pPhtBu in pancreatic cancer cells enhances the efficacy and potential clinical importance of these compounds for cancer chemotherapeutic applications".

Additionally, in order to reveal more information about DIM induced pancreatic cancer cells apoptosis, researchers analyzed the DIM effect by examing the process through multiple molecular assays.

According to the Western blot analysis, 3,3'-diindolylmethane (DIM) a chemopreventive agent, specifically its more bioavailable formulation, B-DIM, inhibited Par-4, in L3.6pl and Colo-357 pancreatic cancer cells at low doses (20 micromol/L).

At similar doses, DIM reduced cell viability and caused cell growth inhibition and apoptosis.

Also, pretreatment of DIM sensitized the cells to the cytotoxic action of chemotherapeutic drug gemcitabine.

In other words, DIM not only processed anti-pancreatic cancer cells proliferation and induced apoptosis but also promoted the chemotherapeutic drug cytotoxic activity against pancreatic cancer cells.

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of pancreatic cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5,Abdelrahim M1, Newman K, Vanderlaag K, Samudio I, Safe S. (PubMed)
(2) Chemoprevention of pancreatic cancer: characterization of Par-4 and its modulation by 3,3' diindolylmethane (DIM) by Azmi AS1, Ahmad A, Banerjee S, Rangnekar VM, Mohammad RM, Sarkar FH. (PubMed)
(3) Genetic Susceptibility to Pancreatic Cancer by Alison P. Klein. (PMC)

Phytochemical Sinigrin Speeds Up Wound Healing

By Kyle J. Norton

Sinigrin may be used as a natural and bioactive compound for speed-up wound healing, according to studies.

Wound healing is a natural process of immune systematic response to protect our body against the harmful pathogenic invasion.

After receiving the message from the neurons in the brain, the immune first line of defense including the macrophages stimulating the blood palettes to the site of infection to cover the injury and production of pro-inflammatory cytokines to kill off the stimuli and pathogens which try to enter the body through the wound.

Some anti-inflammatory cytokines under normal condition also switch to pro-inflammatory cytokines depending on the severity of the injury.

In some cases, overproduction of pro-inflammatory cytokines can cause damage or death of the nearby cells, leading to the formation of irreversible scars, such as hepatitis infection.

Even worse, if the immune system can not kill off all pathogens in the acute phase of infection, it will compromise to the new change, leading to chronic low-grade inflammation.


Bacterial pathogens often cause infection in specific areas of the body by overgrowth the numbers of bacteria in the site, including the gut.

According to the epidemiological studies, some bacteria are opportunistic pathogens, people with a weakened immune system are particularly prone to their invasion.

Dr. Dennis W. Metzger, the lead scientist wrote, " While it has been commonly thought that viral-induced epithelial cell damage allows bacterial invasiveness, recent studies by several groups have now implicated dysfunctional innate immune defenses following influenza as the primary culprit for enhanced susceptibility to secondary bacterial infections".

The results strongly indicated the increased risk of bacterial infection in people with a weakened immune system.

Researchers on finding a natural compound for speeding up wound healing explored on wound healing effect of sinigrin on HaCaT cells.

In the phytosome with sinigrin with an average particle size of 153 ± 39 nm, the zeta potential of 10.09 ± 0.98 mV and complex efficiency of 69.5 ± 5%.

The formulated sinigrin-phytosome complex significantly exhibited a greater wound healing effect compared to the use of sinigrin alone.

Compared to only 71% wound closer of sinigrin after 42 hours, the phytosome complex completely healed the wound.

 At a lower concentration of 0.07 mg/mL, the sinigrin–phytosome complex displayed 79%, whilst sinigrin showed only 50% of wound closure. 

At the higher concentration 0.14 mg/mL the sinigrin–phytosome complex completely cured the wound (100%), compared to only  71% wound healing of sinigrin.

Furthermore, The sinigrin-phytosome complex displayed minimal toxicity towards HaCaT cells.

Injection of the complex also exerted a strong effect towards A-375, a human melanoma cell line.

Dr. Mazumder A, after taking into account of co and confounders wrote at the end of the experiment, " sinigrin-phytosome complex augmented the therapeutic potential of sinigrin towards the wound healing activity".

Taken altogether, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for speedup wound healing, pending to the confirmation of large sample size and multicenter human study.

However, intake of bioactive in the form of supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi and Jeanetta du Plessis. (Molecules)
(2) In vitro wound healing and cytotoxic effects of sinigrin-phytosome complex by Mazumder A1, Dwivedi A1, du Preez JL1, du Plessis J2.(Pubmed)
(3) Immune Dysfunction and Bacterial Co-Infections following Influenza by Dennis W. Metzger and Keer Sun. (PMC)

Herbal Bilberry, the Best Neuro-Protective Functional Remedy, According to Medical Literature

By Kyle J. Norton

Scientists may have found a herbal remedy which processes a neuron-protective effect against brain diseases, according to studies.

Neurological disorders are diseases associated with the brain, spine and nerves. In other words, they are diseases of the central nervous system.

There are many risk factors involved in the incidence of neurological disorders, including unhealthy lifestyle, infections, genetics preposition, and physical injury.

Oxidative stress is a result of an imbalance of the ratio of levels of free radicals and antioxidant caused either by overexpression of free radicals or depletion of antioxidants enzymes or both.

Free radicals can be produced internally by normal cellular metabolism or from the external sources such as the air we breathe, smoking. Free radicals are unstable molecules with unpaired electrons on the outer ring.

In order for them to maintain stable, free radicals must either donate an electron or intercept an electron from other atoms, leading to a chain reaction that can not stop[ed until the outer ring electron is paired or inhibited by antioxidants.

Oxidative stress has been found to be a major risk for the onset of the neurological disorder in the Western world, particularly in North American.

Dr. Carvalho AN, the lead scientist in the assessment of oxidative stress and antioxidants in neurological diseases, said, "Oxidative stress is a pathological feature common to a multitude of neurological diseases. The production of reactive oxygen species (ROS) is the main mechanism underlying this cellular redox imbalance".

And, "overview of the main players in oxidative stress and outline evidence of their involvement in Parkinson's disease, Alzheimer's disease, Huntington's disease, and multiple sclerosis".

The results clearly suggested the impact of oxidative stress in the facilitation of the onset of neurodegenerative diseases.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Scientists on finding a natural ingredient which processes neuroprotective effects evaluated the activity of Vaccinium myrtillus (bilberry) anthocyanoside (VMA) and/or its main anthocyanidin constituents (cyanidin, delphinidin, and malvidin) against retinal damage.

According to the assays, in the retinal ganglion cells (RGCs) induced cell damage and radical activation by 3-(4-morpholinyl) sydnonimine hydrochloride (SIN-1), injection of VMA and all three anthocyanidins significantly inhibited SIN-1-induced neurotoxicity and free radical activation.

Furthermore, VMA also significantly inhibited the N-methyl-D-aspartic acid (NMDA)-induced morphological retinal damage compared to other derivatives. and increased apoptosis of the damage cells in the ganglion cell layer. 

Moreover, VMA at a concentration-dependently inhibited lipid peroxidation in mouse forebrain homogenates. In other words, VMA prevented the accumulation of lipid peroxidation in the neurons, the major cause of the neuron damage.

The findings suggested that VMA and its anthocyanidins process neuroprotective effects via an anti-oxidation mechanism in vitro and in vivo models of retinal diseases.

Additionally, in order to reveal more information about bilberry neuroprotective activity, researchers examined the antioxidants richly present in bilberry fruits effects on diabetes-related brain dysfunctions.

αCaMKII in hippocampal neurons from non-diabetic, diabetic and diabetic rats before fed with an extract of bilberry fruit showed a reduction of swollen and the lengths of the neuronal fibers. 

Interestingly, diabetic rats fed with bilberry fruit showed a αCaMKII-positive nerve fiber significantly longer compared to the groups of diabetic and control rats. 

The results strongly suggested that bilberry fruits influence the morphology of and possibly exhibit beneficial and neuroprotective effects on hippocampal neurons during diabetes through the expression of antioxidants.

Taken altogether, bilberry processed abundantly bioactive compound such as anthocyanidin and its constituents cyanidin, delphinidin, and malvidin may be considered a functional remedy for the prevention and treatment of neuro-diseases, pending to larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo by Matsunaga N1, Imai S, Inokuchi Y, Shimazawa M, Yokota S, Araki Y, Hara H. (PubMed)
(2) Effect of feeding with bilberry fruit on the expression pattern of αCaMKII in hippocampal neurons in normal and diabetic rats by Matysek M1, Mozel S1, Szalak R1, Zacharko-Siembida A1, Obszańska K1, Arciszewski MB. (PubMed)
(3) Oxidative Stress and Antioxidants in Neurological Diseases: Is There Still Hope? by Carvalho AN1, Firuzi O2, Gama MJ3, Horssen JV4, Saso L. (PubMed)