Ginger, the Anti Liver Cancer Functional Remedy with No Side Effects, According to Studies

By Kyle J. Norton

Scientists may have found a pungent spice which processes potential to protect the liver against the onset of cancer, some studies suggested.

The liver is a large organ in human with the unique function in filtering the blood from the digestive tract, before passing to the rest of the body.

Liver cancer is a chronic condition characterized by cell growth irregularly in the tissue of the liver due to the alternation of cell DNA.

At the early stage of liver cancer, most patients do not experience any symptoms. However, at the advanced stage patients may experience symptoms of jaundice, abdominal sever pain and white, chalky stools accompanied by general cancer symptoms such as weight loss, loss of appetite and gastrointestinal discomforts.

If you are having some of the above symptoms, please make sure you check with your doctor to rule out the possibility of liver cancer.

In most cases, at this stage, liver cancer cell also can induce secondary metastasis through lymph and blood, leading to cancers of colon, pancreas, stomach, lung, and breast.

According to the statistics provided by the American Cancer Society, in 2018, approximately, 42,220 new cases, including 30,610 in men and 11,610 in women of liver cancer were diagnosed. The disease causes the death of 30,200 people, including 20,540 men and 9,660 women.

Liver cancer diagnosed at an early stage has a 5-year survival rate of 31%. Only 43% of patients are diagnosed at 0 and 1.

Although there are many risk factors associated with the onset of liver cancer, hepatitis infection is considered a major cause of the disease. 

Dr. Marc Ringehan and colleagues in the examine hepatitis in risk of liver cancer said, "Hepatitis B and C viruses are a global health problem causing acute and chronic infections that can lead to liver cirrhosis and hepatocellular carcinoma (HCC)".

And, "The majority of viral-associated HCC cases develop in subjects with liver cirrhosis; however, hepatitis B virus infection can promote HCC development without prior end-stage liver disease. Thus, understanding the role of hepatitis B and C viral infections in HCC development is essential for the future design of treatments and therapies for this cancer".

These results strongly suggested if you are hepatitis carrier, your risk of liver cancer increases substantially.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural compound for the treatment of liver cancer investigated 6-shogaol and 6-gingerol, two active compounds in ginger (Zingiber officinale) anti-invasive activity against highly metastatic hepatoma cells.

6-gingerol and 6-shogaol regulate the transcription. involved cell proliferation and inhibited differentiation.

6-gingerol at a concentration ≥ 10 μM directly decreased expression of urokinase-type plasminogen activator (uPA) in stimulating tumor invasion and development of metastases.

But the 6-shogaol at the concentration ≥ 10 μM -mediated decreased uPA was accompanied by the inhibiting tumor growth, invasion, and metastasis.

Futhermore, the efficacy of anti-liver cancer of both compounds was attributed to significantly inhibit the phosphorylation of proteins associated with cellular processes and activate proteins involved anti-proliferation and transcription of DNA, cytokine production.

These results suggested that 6-Shogaol and 6-gingerol effectively inhibit invasion and metastasis of hepatocellular carcinoma through complex and diverse molecular mechanisms.

In order to reveal additional information about ginger anti-liver cancer activity, researchers examine gingerol, a bioactive compound isolated from ginger for the potential chemo-modulatory effects in addition to potential vascular protective roles with doxorubicin.

Shogaol and 4'-methoxygingerol showed considerably cytotoxic effects against HepG2 cells, with IC50 values ranging from 3.1 to 19.4 µM.

Furthermore, gingerol significantly enhanced the cytotoxic profile of doxorubicin against HepG₂ and Huh7, cells decreasing its IC50s by 10- and 4-fold, respectively.

Doxorubicin alone induced cell accumulation at S-phase and G₂/M-phase, while in combination with gingerol it significantly induced cell cycle arrest at the G₂/M-phase.

Dr.Al-Abbasi FA and colleagues in the final report wrote, "gingerol protected from DOX-induced vascular damage, apparently not through a ROS scavenging mechanism".

The findings strongly suggested that gingerol not only exerts a significantly liver protective effect but also improves the doxorubicin efficiency and reduces chemo side effects.

Taken altogether, ginger processed abundantly bioactive compound may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of liver cancer, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Molecular mechanism inhibiting human hepatocarcinoma cell invasion by 6-shogaol and 6-gingerol by Weng CJ1, Chou CP, Ho CT, Yen GC. (PubMed)
(2) Gingerol Synergizes the Cytotoxic Effects of Doxorubicin against Liver Cancer Cells and Protects from Its Vascular Toxicity by Fahad Al-Abbasi, Eman A Alghamdi, Mohammed A. Baghdadi.
Ahmed M Al-Abd, (PubMed)
(3) Viral hepatitis and liver cancer by Marc Ringehan,1,2,3 Jane A. McKeating,4,5 and Ulrike Protzer. (PMC)

Herbal Calendula, Protects Lipid, Protein and Cells DNA Against Damage Caused by Oxidative Stress

By Kyle J. Norton

Scientists may have found a natural remedy for the prevention and treatment of the diseases associated with the expression of oxidative stress, according to studies.

Antioxidants are stable molecules that inhibit the oxidation induced by free radical.
Free radicals are unstable and high reactive molecules with a single electron in the outer ring.

In order for them to become stable, free radicals are ready to donate or intercept an electron from other molecules, leading to a chain reaction that cannot be stopped until the electrons on the outer ring are paired or inhibited by antioxidants.

Oxidative stress is a condition caused by either overexpression of free radical or low levels of antioxidant enzymes produced by the host body.

In other words, the unbalanced ratio of the levels of free radicals and antioxidants enzymes is the major cause of the onset of oxidative stress, leading to the damage of lipid, DNA, and protein in the cells of the host.

Although there are many risk factors associated with the development of the condition, some researchers suggested that smoking is one of the preventable and major risks in the induction of the onset of oxidative stress.

Dr. Isik B in the comparison of the risk of oxidative stress in smokers and nonsmokers wrote, "Smoking may enhance oxidative stress not only through the production of reactive oxygen radicals in smoke but also through the weakening of the antioxidant defense systems".

And, ": The serum MDA levels were significantly higher (p < .05) and serum PON1 activities were significantly lower (p < .001) in smokers than in nonsmokers".

Where serum malondialdehyde (MDA) is an oxidative stress marker and paraoxonase (PON1) is an HDL-associated enzyme which protects the HDL against oxidation.

Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.

The herbal medicine has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and for the treatment of abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.


Besides major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.

Researchers on finding a herbal medicine which process a high amount of antioxidants examined the
Calendula officinalis flower extract effects against experimentally induced thermal burns made on the shaven back of the rats under anesthesia in rats.

The animals then are treated orally with different doses of the flower extracts (20 mg, 100 mg, and 200 mg/kg body weight). 

Injection of the extracts showed significant improvement in healing when compared with the control untreated animals.

The wound healing is observed by the speeding up through the increase of the concentration of collagen contents in the treated group.

The acute phase proteins associated with the oxidative activity was increased due to burning were found to be decreased significantly in 200 mg/kg body weight extract treated animals.

The antioxidant defense mechanism decreased in the liver during burn injury, was found to be enhanced in treated animals. 

The lipid peroxidation was significantly lowered in the treated group, accompanied by a decrease of the tissue damage marker compared to control animals.

Furthermore, in the investigation of the Flower extract of C. officinalis L. protective effect against CCl4 induced acute hepatotoxicity and cisplatin-induced nephrotoxicity, pretreatment of the flower extract at 100 and 250 mg/kg body weight exerted a significant reduction of the tissue and oxidative stress makers compared to untreated group.

The extract displayed a liver protective effect observed by the decreased levels of lipid peroxidation the marker of membrane damage and the total bilirubin content in the liver.

Moreover, the herbal extract also demonstrated kidney protective effects observed by the reduced levels of the kidney function markers, urea, and creatinine which were significantly increased in cisplatin-treated animals.

Additionally, the cisplatin-induced myelosuppression was ameliorated by the extract pretreatment, through enhancing the levels of antioxidant enzymes, such as superoxide dismutase and catalase and glutathione.

Dr. Preethi KC, the lead scientist wrote in the final report, "Possible mechanism of action of the flower extract may be due to its antioxidant activity and reduction of oxygen radicals".

Taken altogether, herbal Calendula may be considered a functional remedy for the protection of our body against disease associated with oxidative stress, through its antioxidant activity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: a randomized controlled clinical study. by Babaee N, Moslemi D, Khalilpour M, Vejdani F, Moghadamnia Y, Bijani A, Baradaran M, Kazemi MT, Khalilpour A, Pouramir M, Moghadamnia AA. (PubMed)
(2) Effect of Calendula officinalis Flower Extract on Acute Phase Proteins, Antioxidant Defense Mechanism and Granuloma Formation During Thermal Burns by Chandran PK, Kuttan R.(PubMed)
(3) Hepato and reno protective action of Calendula officinalis L. flower extract by Preethi KC, Kuttan R.(PubMed)

Herbal chamomile in the Prevention and Treatment of Anxiety Disorders

By Kyle J. Norton

Herbal Chamomile may have a potential effect in reducing risk and treatment of anxiety disorder, according to studies.

Anxiety disorders are a group of mental illnesses characterized by symptoms of excessive anxiety, fear, worry, avoidance, and compulsive rituals. The condition is more commonly in women than in men.

Some researchers suggested that anxiety disorders are conditions associated with the combination of biological, psychological, and individual factors and the most commonly reported psychiatric conditions and frequently occur as comorbid disorders.

According to the statistic, anxiety disorders are the most common mental illness in the U.S., affecting 40 million adults in the age of 18 and older, or 18.1% of the population every year.

The exact causes of anxiety disorders are debatable. However, a family history of anxiety recent or prolonged exposure to stress, excessive consumption of stimulants such as caffeine or tobacco is associated with the onset of the disorders.

The symptoms of anxiety disorders can be psychological or physical, including difficulty concentrating and sleeping,  irritability,  persistent stomachaches or diarrhea,  sweaty palms, shaking and rapid heartbeat.

If you experience some of the above symptoms, please make sure you check with your doctor to rule out the possibility.

Dr. Lykouras L, the lead scientist in the investigation of the connection between body weight and anxiety disorders wrote, "Obesity has been associated with anxiety disorders as follows: most of the studies show a positive relationship with panic disorder, mainly in women, with specific phobia and social phobia" and "Some authors have found a relationship with generalized anxiety disorder but a negative relationship has been also reported".

The results clearly indicated if you are obese, your risk of anxiety disorders is increased substantially compared to normal weight people.

Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae. The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and for the treatment of menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.

In a randomized, double-blind, placebo-controlled efficacy and tolerability trial of Matricaria recutita (chamomile) extract on generalized anxiety disorder (GAD) showed to effective of modest anxiolytic activity with patient mild to moderate GAD(1). The University of Ottawa study on the effects of Matricaria recutita (German chamomile) and Humulus lupulus (hops) showed significant activity in the inhibition of GAD  at doses of 0.11-0.65 mg/mL(2).

The study containing 57 participants in the 2009 trial, 19 had anxiety with comorbid depression; 16 had anxiety with a past history of depression, and 22 had anxiety with no current or past depression, chamomile showed a clinically meaningful antidepressant activity to its previously observed anxiolytic activity(3).

 Apigenin, a component of Matricaria recutita flowers, in mice study, exerted its anxiolytic and slight sedative effects through the central benzodiazepine receptors(4).

Researchers at the University Science Center on finding a treatment of anxiety disorder examined the effects of chamomile extract therapy in patients with mild to moderate generalized anxiety disorder (GAD) on a randomized, double-blind, placebo-controlled efficacy and tolerability trial.

In a total of 63 outpatients with mild to moderate GAD enrolled, 57 were randomized to either double-blind chamomile extract (n = 28) or placebo therapy (n = 29) for 8 weeks.

Chamomile treated group exerted a significantly greater reduction in mean total HAM-A score compared to the placebo.

Furthermore, besides the better primary outcomes, chamomile group also demonstrated a positive change in all secondary outcomes in the reduction of anxiety symptoms.

Mild and tolerated adverse events or more was not significantly different between groups.

The findings clearly suggested herbal chamomile extract processes a modest anxiolytic activity in patients with mild to moderate GAD. 

Moreover, in the evaluation of the chamomile effect on gamma-aminobutyric acid (GABA) which is a neurotransmitter that blocks impulses between nerve cells in the brain researchers compared the herbal plants which were used in the traditional medicine for the treatment of anxiety disorders.

 Gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter has been found to initiate the risk of anxiety or mood disorders in low levels

In vitro rat brain homogenate assays, compared to other herbal plants such as Melissa officinalis, Centella asiatica (Gotu Kola) and Valeriana officinalis (Valerian), chamomile showed significant inhibition of glutamic acid decarboxylase (GAD) activity (0.11-0.65 mg/mL).

These results strongly suggested that the failure of the interaction of members in the GAGA system caused by dysfunction was attributed to the onset of anxiety disorders.

Additionally, in participants with symptoms of comorbid anxiety and depression, according to the generalized estimating equations analysis to identify clinically meaningful changes over time in scores from the Hamilton Depression Rating (HAM-D) questionnaire among treatment groups, Chamomile group displays a significantly greater reduction over time in total HAM-D scores compared to placebo.

Also, the HAM-D core mood item scores, application of chamomile also showed a significantly greater reduction over time vs placebo in all participants, regardless of the current or past depression.

Taken altogether, herbal chamomile may be considered a functional remedy for the prevention of anxiety disorders in higher risk population and combined with primary medicine for the treatment of anxiety diseases with tolerated adverse effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder by Amsterdam JD1, Li Y, Soeller I, Rockwell K, Mao JJ, Shults J.(PubMed)
(2) Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system by Awad R1, Levac D, Cybulska P, Merali Z, Trudeau VL, Arnason JT. (PubMed)
(3) Chamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans: an exploratory study by Amsterdam JD1, Shults J, Soeller I, Mao JJ, Rockwell K, Newberg AB. (PubMed)
(4) Anxiety disorders and obesity by Lykouras L1, Michopoulos J. (PubMed)

Ginger, the Natural Anti Prostate Cancer Remedy with No Side Effects, Scientists Reveal

By Kyle J. Norton

Scientists may have found a pungent spice which processes a potential for the prevention and treatment of prostate cancer, some studies suggested.

Prostate cancer is a chronic condition caused by the cell growth irregularly and disorderly in the prostate tissue due to the alternation of DNA.

Prostate cancer is one a slow growth of cancer and can be detected during annual rectum exam.

At the early stage, prostate cancer cell which has grown on the surface of the inner lining of the prostate does not cause any symptoms due to the very small size of the tumor.

However, at the later stage, the large tumor size may suppress the nearby blood vessels and nerve cells, leading to internal bleeding and severe pain. Also, cancer cells may also travel a distance away from the stomach to infect other healthy tissue and organs, leading to a secondary metastasis.

Common sites metastases of prostate cancer are bone, lymph nodes, lung, liver.

Researchers do not know the exact causes of prostate cancer. However, they do know the increase in age, family and personal history, ethnicity, genetic preposition, a poor diet, being overweight or obesity are some of the prevalent risk factors of prostate cancer.

According to the Canadian Cancer Society, in 2017, 21,300 men were diagnosed with prostate cancer, represented 21% of all new cancer cases and 4,100 men died from prostate cancer, and 10% of all cancer deaths.

The 5 years survival rate of localized prostate cancer is 100% and 98% of that of survivors are alive after 10 years compared to the advanced stage of only 31%.

Some researchers concerned the widespread prostate cancer in North America, northwestern Europe, Australia, and on Caribbean islands compared to Asia, Africa, Central America, and South America, said, "One of the most striking characteristics of prostate cancer is the degree of geographic variation in its patterns of occurrence and progression; this variation is apparent at local, national, and international levels".

And "the known factors influencing the biology and epidemiology of prostate cancer and some of the ways in which findings to date have benefited from geography".

The results strongly indicated there must be something happened in the Western world that does not found in the East and Africa, Central America, and South America.

Some researchers suggested it may be the Western diet.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

In the concern of prostate cancer risk in men in the Western world and its related mortality and morbidity, researchers in the cancer team at the The University of Texas at Austin examined the anti-prostate cancer effect of 6-Shogaol (6-SHO), a potent bioactive compound in ginger (Zingiber officinale Roscoe).

Injection of the bioactive compound effectively reduced survival and induced apoptosis of cultured human (LNCaP, DU145, and PC3) and mouse (HMVP2) prostate cancer cells.

6-SHO reduced the expression of pro inflammatory cytokines in the activation of the proteins involved cell proliferation and the capacity for metastasis.

Furthermore, 6-SHO also inhibited the expression of cytokines in the stimulation of proteins and genes associated with the anti apoptotic activity and tumor cells survival.

6-SHO was more effective than two other compounds found in ginger, 6-gingerol, and 6-paradol at reducing survival of prostate cancer cells. 

Moreover, 6-SHO also showed significant tumor growth inhibitory activity in an allograft model in HMVP2 cells.

In other words, 6-SHO inhibited prostate cancer through several mechanisms, including chemokine, cytokine, cell cycle, apoptosis, and genes.

Dr. Saha A and colleagues wrote in the final report, "6-SHO may have potential as a chemopreventive and/or therapeutic agent for prostate cancer".

Additionally, in order to reveal more information about ginger as a promising chemopreventive agent, researchers examined the ginger extract (GE) growth-inhibitory and death-inductive effects in a spectrum of prostate cancer cells. 

Injection of the extract showed a significant effect on perturbed cell-cycle progression, impaired reproductive capacity, modulated cell-cycle, and apoptosis in human prostate cancer cells. 

Daily oral feeding of 100 mg/kg body weight of GE inhibited growth and progression of PC-3 xenografts by approximately 56 % in nude mice, observed by the tumor tissue from GE-treated mice compared to controls.

Most importantly, GE is safe as toxicity is not detected in normal, rapidly dividing tissues such as gut and bone marrow. 

Taken altogether, ginger processed 6-Shogaol (6-SHO) may be considered a function remedy for the prevention and combined with the primary medicine for treatment of prostate cancer with no side effects, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.


Sources
(1) 6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-κB signaling by Saha A1, Blando J1, Silver E1, Beltran L1, Sessler J1, DiGiovanni J. (PubMed)
(2) Benefits of whole ginger extract in prostate cancer by Prasanthi Karna,1 Sharmeen Chagani,1 Sushma R. Gundala,1 Padmashree C. G. Rida,1Ghazia Asif,1 Vibhuti Sharma,1 Meenakshi V. Gupta,2 and Ritu Aneja. (PubMed)
(3) What can geography tell us about prostate cancer? by Klassen AC1, Platz EA. (PubMed)

Ginger, The Potential Anti Ulcerative Colitis Functional Spice

By Kyle J. Norton

Ginger may be considered a natural whole food for the treatment of acute ulcerative colitis (UC) with no side effects, some scientists suggested.

Ulcerative colitis (UC) can be an acute or chronic inflammation of the membrane-lined the colon or the large intestine. People with UC are at higher risk for developing colorectal cancer, compared to the general population.

Acute inflammation is a process of inflammation in response to tissue injury, that occurs over a short period of time and can be resolved within a time frame.

Most people with acute inflammation experience the symptoms of pain, redness, swelling, and heat.

According to the American Family Physician, between 250,000 and 500,000 people in the United States were affected by ulcerative colitis.

The exact causes of ulcerative colitis. are debatable. Researchers do not know why people with the same health conditions in the family, some members are susceptible to the onset of the condition, while others do not

However, according to the epidemiological studies genetic mutation, environment, and a weakened immune system may be the prevalent risk factors associated with ulcerative colitis.

Dr. Yuan Huang, the lead scientist, in the concern of the weakened immune system in the risk of inflammatory bowel disease, including ulcerative colitis (UC) and Crohn’s disease (CD) said, " after environmental factors act on individuals with genetic susceptibility, an abnormal intestinal immune response is launched under stimulation of intestinal flora".

The team explained, "Inflammatory bowel disease-related immune disorders. The innate immune abnormalities of inflammatory bowel disease lead to adaptive immune disorders,... The inflammatory cytokines, in turn, increase the innate immune damages,.... abate the intestinal barrier function, and aggravate inflammation. Therefore a vicious circle forms.

The immune disorder caused by the inability to kill off all the invader pathogens in the acute phase of inflammation at the colon can lead to immune compromise of the host in facilitating chronic low-grade inflammation disease, such as chronic ulcerative colitis (UC).

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to reaffirm the traditional use of ginger for the treatment of ulcerative colitis, one of the most common types of inflammatory bowel disease, researchers evaluated the 6-Gingerol, a component of gingerols extracted from ginger (Zingiber officinale) anti ulcerative colitis effect.

In the selected rat model, colitis was induced in rats through consumption of 5% (cw/v) dextran sulfate sodium drinking water for 7 consecutive days before 6-Gingerol, 8-gingerol, and 10-gingerol were given intraperitoneally at doses of 30 mg kg-1 d-1 for another 7 days,

At the end of the experiment, researchers found that all three gingerols attenuated colitic symptoms evoked by dextran sulfate sodium

Application of 6-Gingerol, 8-gingerol, and 10-gingerol significantly elevated superoxide dismutase activity, decreased malondialdehyde levels and myeloperoxidase activity in the colon tissue.

The applications also strongly decrease the expression of proinflammatory cytokines expression.

All three gingerols obviously accelerated mucosal damage healing.

Dr. Zhang F, the lead author said, "6-gingerol, 8-gingerol, and 10-gingerol, the three analogs, have a strong and relatively equal efficacy in the treatment of colitis".

Further investigation of the gingerols, the phenolic compounds in ginger (Zingiber officinale) anti-inflammatory and antioxidant effects, researchers examined the gingers activity against a mouse model of dextran sulfate sodium (DSS)-induced ulcerative colitis.

Adult male selected mice were either exposed to DSS in drinking water alone or co-treated with 6-gingerol orally at 50, 100, and 200 mg/kg for 7 days.

Mice co-treated with 6 gingerols significantly reversed the DSS-mediated reduction in body weight, diarrhea, rectal bleeding, and restored the colon shrinkage back to near normal.

Application of 6-gingerol significantly suppressed the circulating concentrations of proinflammatory cytokines caused by injection DSS and reactivity the systematic immune response through increasing the myeloperoxidase activity.

Moreover, 6-gingerol also restored the function of the colon in response to waste material.

The efficacy of 6-gingerol in the inhibition of ulcerative colitis was attributed to the stimulation of the increasing activities of antioxidant enzymes and glutathione content, decreasing the hydrogen peroxide and malondialdehyde levels.

In other words, 6-gingerol restored the balanced ratio of free radicals and antioxidants in the tested mice injected by DSS.

Dr. Ajayi BO, the lead scientist said, " 6-Gingerol suppressed the induction of ulcerative colitis in mice via and anti-inflammatory activities, and may thus represent a potential anti-colitis drug candidate".

Taken altogether, ginger processed a high amount of bioactive gingerols may be considered a functional food for the prevention and combined with other primary therapy for the treatment of ulcerative colitis with no side effects

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Therapeutic Effects of 6-Gingerol, 8-Gingerol, and 10-Gingerol on Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis in Rats by Zhang F1, Ma N1, Gao YF1, Sun LL1, Zhang JG. (PubMed)
(2) Pharmacological activity of 6-gingerol in dextran sulphate sodium-induced ulcerative colitis in BALB/c mice by Ajayi BO1, Adedara IA, Farombi EO. (PubMed)
(3) Modulating effect of ginger extract on rats with ulcerative colitis by El-Abhar HS1, Hammad LN, Gawad HS. (PubMed)
(4) Inflammatory bowel disease related innate immunity and adaptive immunity by Yuan Huang1,* and Zhonge Chen2. (PubMed)

Honey Speeds Up Wound Healing with Anti infection Activity

By Kyle J. Norton 

Honey may have a strong effect in speeding up wound healing, some scientists suggested.

Wound healing is the natural process by covering up the damage and injury of the body,

The process involves 4 phases
* The first phase of wound healing is cover up the wound. In this phase, the immune first line of defense white blood cells stimulates the emergency repair system in the production of blood clotting to block the drainage.

* In phase 2, the white blood cells activates the proteins associated with the inflammatory cytokines to destroy the pathogens before they can enter the body through the wound.

* In phase 3, new blood vessels and tissues are formed in the damage and injury area.

* The recovery phase.

However, the healing process is easier said than done, the complex process in many cases are interrupted by local and systemic factors, including moisture, infection, age, and nutritional status.

Some researchers also indicated that in phase 2, due to overexpression of inflammatory cytokine, some patients may experience symptoms of localized redness, swelling, and fever. 

And, the overexpression of inflammatory cytokines can also cause damage to the nearby healthy cells, leading to improper healing with the formation of large and irreversible scars.

However, people with a weakened immune system may compromise acute wound repair that promotes nonhealing wounds.

Dr. Amanda S. MacLeod, the lead author in the concerns of the immune responses to acute and chronic wound said, "The innate immune system comprises a network of interacting mechanisms that provide a rapid response to clear microbial contamination upon skin injury" and  "In the development of chronic wounds, this process stalls in the late inflammatory stage. The major defect in nonhealing wounds occurs at the phenotypic switch from inflammatory macrophages to an anti-inflammatory phenotype".

These results clearly, suggested, the failure to switch from the phase of proinflammatory cytokines to the phase of anti-inflammatory cytokines due to the weakened immune system in the activation of p38, can lead to delayed wound healing and abnormalities in chronic wounds.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

In the referring traditional use of honey for wound healing and an alternative natural antibiotic due to the advent of antibiotic resistance in microbial pathogens, researchers reviewed articles outlined publications regarding honey and wound healing that have been published between June 2010 and August 2016. 

The findings suggested that multiple types of honey demonstrate their mechanisms of action as antimicrobial agents, immunologic modulators, and physiologic mediators.

In the evaluation to examine the healing effects of honey dressings compared to silver dressings for acute or chronic wounds, researchers launched a systematic review with meta-analysis consisted of six randomized controlled trial studies.


All studies showed that honey was more efficacious for wound healing than silver, as measured in the number of days needed for wounds to heal.

Honey turned out to have more antibacterial qualities than silver in-depth analysis.

Dr. Lindberg T, the lead scientist after taking into account co and confounders, said, "All the included studies based on burns showed the unequivocal result that honey had an even more positive effect than silver on wound healing".

The results pointed out that honey may have a potential effect in speeding up the wound healing and protect the wound against microorganisms infection.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Honey and Wound Healing: An Update by Saikaly SK1, Khachemoune A2. (PubMed)
(2) A systematic review and meta-analysis of dressings used for wound healing: the efficiency of honey compared to silver on burns by Lindberg T1, Andersson O1, Palm M1, Fagerström C, (PubMed)
(3) Biological properties and therapeutic activities of honey in wound healing: A narrative review and meta-analysis by Oryan A1, Alemzadeh E2, Moshiri A3. (PubMed)
(4) The Innate Immune System in Acute and Chronic Wounds by Amanda S. MacLeod1, and Jonathan N. Mansbridge. (PMC)

Diallyl trisulfide (DATS), the Bioactive compound isolated from Garlic May Be A Potential Anti Skin Cancer Agent

By Kyle J. Norton

Polysulfides isolated from the organosulfides may have a profound effect in reducing the risk and treatment of skin cancer, according to studies.

Skin, a large organ that forms the out layers of our body has a serval layers of ectodermal tissue and protects the underlying muscles, bones, ligaments and internal organs against foreign pathogenic invasion.

Skin cancer is a medical condtion characterized by disordered and irregular cell growth in the skin.

Most cases of primary skin cancer start in the cell on the surface of the inner ling of the skin. At the advanced stage, the cancerous cells can travel a distance away from the skin to infect other healthy tissue and organ through blood and fluid circulation.

There are 3 main types of cells in the top layer of the skin (called the epidermis):
Squamous cells, Basal cells, and Melanocytes.

Long-term cumulative sun exposure is one of the major cause of basal cell and squamous cell skin cancer. Exposure to ultraviolet (UV) radiation is the leading cause of melanoma.

Certain risk factors that make some people susceptible to the development of skin cancer than others, include the increase in age, weakened immune system, gender, skin tone, genetic preposition, and family history.

Some researchers also suggested that the general knowledge about the protection of skin against the onset of skin cancer is lacking, therefore, more education in this field may be necessary before the prevalence of skin cancer can be reduced. 

Dr. Lee Wheless, the lead scientist in the concern of the association between skin characteristics and skin cancer prevention behaviors said, "Behaviors such as sunscreen use and wearing sun-protective clothing are thought to prevent certain types of skin cancer and precancerous lesions". 

However, "The overall prevalence of prevention behaviors was low. Those with phenotypic risk factors for skin cancer were most likely to use sunscreen and sun-protective clothing. Those with high-risk skin cancer phenotypes may also be those who are most receptive to skin cancer prevention educational interventions".

Polysulfides are phytochemicals in a class of chemical compounds containing chains of sulfur atoms, belonging to the group of Organosulfides found abundantly in the oxidized product, including beer, wine, whiskey, garlic oil, etc.

In the concern of incidence of skin cancer which increases at an alarming rate, researchers at the National Taiwan University evaluated the anti-skin cancer activity of sulfur metabolites in garlic oil.
Diallyl trisulfide (DATS), a member of polysulfides was found to be more potent than mono- and disulfides against skin cancer.

Injection of DATS inhibited cell growth of human melanoma A375 and basal cell carcinoma (BCC) cells by increasing the cytotoxicity of the reactive oxygen species (ROS).

Furthermore, DATS also induced apoptosis of skin cancer cells through inducing the DNA damage and through cell cycle arrest at the G2/M phase, endoplasmic reticulum (ER) stress associated with the cancer cells proliferation and survival, and mitochondria-mediated apoptosis.

These results indicated the importance of DATS in the prevention and treament of skin cancer by focusing on molecular mechanisms.

Furthermore, in the depth analysis of the effects of Diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS), extracts from crushed garlic by steam-distillation against human melanoma A375 cells and basal cell carcinoma cells, researchers showed that DATS reveals better growth inhibition of A375 and BCC cells than DADS and DAS do.

Similar to the previous study, DATS increased intracellular reactive oxygen species (ROS) generation in the induction of cytotoxicity to the tested cancer cell lines.

The cell viability analysis reconfirmed the previous finding that DATS kills tested cancer cells in G(2)/M arrest.

Interestingly, DATS activated the p53 pathway in response to the oxidative DNA damage.
Where p53 is a protein associated with the regulation of the cell cycle and function as a tumor suppression.

Dr. Wang HC, the lead scientist wrote in the final report of the experiment, "DATS also displayed a selective target of growth inhibition between skin cancer cells and normal keratinocyte HaCaT cells".

Taken altogether, Diallyl trisulfide (DATS)  a bioactive compound from garlic may be used for the prevention and treatment of skin cancer, pending to reconfirmation of the larger sample size and multicenter human study.

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression by Wang HC1, Pao J, Lin SY, Sheen LY. (PubMed)
(2) Allyl sulfides inhibit cell growth of skin cancer cells through induction of DNA damage mediated G2/M arrest and apoptosis By Wang HC1, Yang JH, Hsieh SC, Sheen LY. (PubMed)
(3) Diallyl sulfide protects against ultraviolet B-induced skin cancers in SKH-1 hairless mouse: analysis of early molecular events in carcinogenesis by Cherng JM1, Tsai KD, Perng DS, Wang JS, Wei CC, Lin JC.(PubMed)
(4) The association between skin characteristics and skin cancer prevention behaviors by Lee Wheless,1 Ingo Ruczinski,3 Rhoda M. Alani,6,7 Sandra Clipp,4,10Judith Hoffman-Bolton,4,10 Timothy J. Jorgensen,4,11 Nanette J. Liégeois,6,8,9Paul T. Strickland,5 and Anthony J. Alberg. (PMC)