Ginger, The Potent Anti Alzheimer's disease Inhibitor, Scientists Say

By Kyle J. Norton

Ginger may be the next pharmaceutical target to extract a single ingredient medicine for the treatment of Alzheimer's disease, some scientists found.

Alzheimer's disease is a common neurodegenerative disease in the elderly characterized by slowly destroys memory and thinking skills and, eventually, the ability to carry out the daily tasks.

According to the to the Centers for Disease Control and Prevention (CDC), Alzheimer’s disease falls sixth on the list of leading causes of death in the United States.

The average time from diagnosis to death was about four years.

Alzheimer's disease is also increased with the increase in age. In the total of 2,566 people, ages 65 and older under the test of dementia, 559 participants without dementia at the start of the study developed Alzheimer’s disease.

Most common causes of Alzheimer's disease are the combination of genetic, lifestyle, and environmental factors.

However, aging is one most risk factors associated with the onset of the disease in the elderly. Statistics show, the number of people with the disease doubles every 5 years beyond age 65. About one-third of all people age 85 and older may have Alzheimer's disease.

Some researchers suggested that the increase in age and risk of Alzheimer's disease can be attributed to the shrinking of certain parts of the brain, and long-term low-grade inflammation, neuron damage induced by oxidative stress due to overexpression of free radicals.

Dr. Tuppo EE, the lead author of the neuro team at the Western University of Health Sciences said, "There is increasing evidence that free radical-induced oxidative damage may play a role in the pathogenesis of Alzheimer's disease. Free radicals are reactive oxygen compounds that may attack and damage lipids, proteins, and DNA".

And, "The brain is especially sensitive to oxidative damage because of its high content of readily oxidized fatty acids, high use of oxygen, and low levels of antioxidants".

These results clearly suggested that people who follow a healthy diet with high antioxidants such as fruits and vegetables, whole grain and fewer in red meat and processed foods may have a substantially lower risk of Alzheimer's diseases.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

On finding the natural ingredient and whole food with a potential effect on patients with Alzheimer's disease, researchers looked into Ginger (Zingiber officinale), a common dietary adjunct that not contributes to the taste and flavor of foods, but also contain a number of potentially bioactive phytochemicals having valuable medicinal properties.

The differentiation of the binding interactions between active ginger components and various anti-Alzheimer drug targets, researchers suggested the approach could be a promising computational tool to aid optimization of lead compounds obtained from the ginger.

The hydrophobic/hydrophilic interactions of ligands isolated from ginger showed to target acetylcholinesterase, the functioning neurotransmitters, and receptors c-Jun N-terminal kinase which plays an important role in the onset of cognitive impairment.

Additionally, researchers found that all isolated compound is satisfied the Lipinski's rule of five, making them potentially promising drug candidates for the treatment of Alzheimer's disease.

Where Lipinski's rule of five is simply the rule of five (RO5) is a rule to determine if a chemical compound with a certain pharmacological or biological activity has chemical properties.

Moreover, the in-depth investigation of the possible mechanisms of action of these compounds against the AD, scientists compared 4 bioactive compounds isolated from ginger to inhibitors of human acetylcholinesterase (HssAChE), the HssAChE inhibitor and commercial drug in use against the AD, donepezil (DNP).

Unsurprisingly, two among the compounds studied: (E)-1,7-bis(4-hydroxy-3-methoxyphenyl) hept-4-en-3-on and 1-(3,4-dihydroxy-5-methoxyphenyl)-7-(4-hydroxy-3- ethoxyphenyl) heptane-3,5-diycl diacetate, are considered promising new HssAChE inhibitors that could be as effective as DNP.

Based on these results, researchers said, "the binding of the studied compounds in the different binding pockets inside HssAChE and established the preferred interactions to be favored in the design of new and more efficient inhibitors".

Taken altogether, ginger processed abundant bioactive compounds that act as acetylcholinesterase (HssAChE) inhibitor may be used as a functional food for the prevention and treatment of Alzheimer's disease without inducing any side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer's drugs: a computational investigation by Azam F1, Amer AM2, Abulifa AR2, Elzwawi MM2. (PubMed)
(2) A molecular dynamics study of components of the ginger (Zingiber officinale) extract inside human acetylcholinesterase: implications for Alzheimer disease by Cuya T1, Baptista L2, Celmar Costa França T. (PubMed)
(3) Ginger fermented with Schizosaccharomyces pombe alleviates memory impairment via protecting hippocampal neuronal cells in amyloid beta1-42 plaque injected mice by Huh E 1, Lim S , Kim HG , Ha SK , Park HY , Huh Y , Oh MS. (PubMed)

Phytochemical Triterpenoid Which Inhibits Nonalcoholic Fatty Liver Disease

By Kyle J. Norton

Scientists may have found a bioactive ingredient for the prevention and treatment of nonalcoholic fatty liver disease with no side effects, according to studies.

Nonalcoholic Fatty liver disease (NAFLD) is a condition of the fatty liver diseases as a result of accumulated of fat in the liver over time, not caused by abusive alcohol consumption.

Most patients in the early stage of nonalcoholic fatty liver disease do not experience any symptoms until the disease has advanced to the critical stage.

According to the statistic, NAFLD is the most common cause of liver disease in the Western world.

Most diseases associated with NAFLD are obesity, high blood pressure, diabetes, and high cholesterol.

People with insulin resistant, diabetes, high blood pressure, high blood fat levels and/or the metabolic syndrome, are associated with an increased risk of NAFLD.

Other risk factors on the incidence of NAFLD are the increase in age, ethnicity and family history.

Believe or not, people who carry certain mutated gene also at a higher risk of the disease. Dr. Silvia Sookoian in the concern of the global epidemic risk of Nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease wrote, "Although the disease is relatively benign in the early stages, when severe clinical forms, including nonalcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma, occur, they result in worsening the long-term prognosis.". 

And, " A growing body of evidence indicates that NAFLD develops from a complex process in which many factors, including genetic susceptibility and environmental insults, are involved".

Triterpenoid is various unsaturated hydrocarbons, found in essential oils and oleoresins of plants, including Ilex hainanensis Merr.

On finding a natural ingredient or whole food for the prevention and treatment of non-alcoholic fatty liver disease with no side effects, researchers at the China Pharmaceutical University evaluated the effect of the triterpenoid-rich fraction (TF) from Ilex hainanensis Merr. on NAFLD in an animal model.

The study included Male Sprague-Dawley (SD) rats fed a normal diet (control) or high-fat diet (NAFLD model) 4 four weeks, following by the orally administrated TF (250 mg/kg) for another two weeks.

Before application of TF compound, rats fed a high-fat diet displayed an abnormally high blood cholesterol levels and a decline in liver function compared to control.

Application of TF on these rats not only restores the health issues caused by high-fat diet but also decreased the expression of plasma levels of triglyceride, total cholesterol, low-density lipoprotein cholesterol, and the high-density lipoprotein cholesterol.

Levels of alanine transaminase (p < 0.05), aspartate aminotransferase (p < 0.01), liver index (p < 0.05), the indication of liver oxidative stress and insulin resistance index (p < 0.05) were also decreased by TF adminsitration.

Futhermore, TF improved the liver lesions induced by the high-fat diet.

Moreover, TF injection also alleviated oxidative stress and inflammation status indicated by the decline levels of oxidative markers, free radicals, and pro-inflammatory cytokines.

Dr. Cui WX, the lead scientist, after taking into account co and confounders said, "TF has the potential ability to protect the liver against NAFLD by regulating lipids metabolism and alleviating insulin resistance, inflammation and oxidative stress".

Additionally, the study to reconfirm the traditional use of herbal Ilex hainanensis Merr. for the treatment of non-alcoholic fatty liver disease, researchers examine the compound Chlorogenic acid, kaempferol-7-O-β-d-glucoside, and ilexgenin, a novel triterpenoid, the three major bioactive components in I. hainanensis extract.  

Compared to normal rats, application of I. hainanensis extract exerted a significant change in NAFLD rats.

The efficacy of the herbal extract was attributed to the anti-NAFLD activity of chlorogenic acid, kaempferol-7-O-β-d-glucoside, and ilexgenin A.

Taken altogether, phytochemical Triterpenoid may be considered a supplement for the prevention and treatment of non-alcoholic fatty disease pending to the large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Reference
(1) Pharmacokinetic study of major bioactive components in rats after oral administration of extract of Ilex hainanensis by high-performance liquid chromatography/electrospray ionization mass spectrometry by Jie Yanga,1, Fang Lva, 1, Xiao-qing Chenb, Wei-xi Cuia, Li-hong Chenc, Xiao-dong Wena, Qiang Wanga(Science direct)
(2) Triterpenoid-rich fraction from Ilex hainanensis Merr. attenuates non-alcoholic fatty liver disease induced by high fat diet in rats by Cui WX, Yang J, Chen XQ, Mao Q, Wei XL, Wen XD, Wang Q.(PubMed)
(3) Genetic predisposition in nonalcoholic fatty liver disease by bSilvia Sookoian1 and Carlos J. Pirola2(PMC)

Anacardic Acid, A Bioactive Ingredient Which Processes Anti Lung Cancer Potential

By Kyle J. Norton

Anacardic acids may be considered a bioactive ingredient for the prevention and treatment of lung cancer, some scientists found.

Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. Most cases of primary lung cancer start in the cells on the surface of the inner lining of lung tissue.

At the early stage, most patients do not experience any symptoms. However, as cancer continues to advance, it can put pressure on the nearby healthy tissue such as blood vessel and nerve cell, leading to localized symptoms and severe pain.

At the later stage, lung cancells can also travel through blood and fluids circulation to infect other healthy tissue and organ, leading to secondary metastasis.

According to the 2007 statistic, the most common form of primary lung cancers is derived from epithelial cells. In the US, lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women.

The most common form of lung cancer metastasis is brain cancer, according to the statistic, approximately, 40 percent of people with advanced lung cancer will develop brain cancer sometimes during the disease.

The causes of lung cancer are unknown. However, epidemiologically suggested that although there are many risk factors associated with the onset of lung cancers, smoking tobacco, and second-hand smoke are considered the most risk of the diseases.

Other risk factors include radon asbestos, occupational exposure to certain chemicals, outdoor air pollution, personal or family history of lung cancer,  personal history of lung disease and long-term exposure to radiation.

Dr. Muhammad Furrukh, in the concern of  tobacco smoking in the risk of lung cancer, said, "Tobacco smoking remains the most established cause of lung carcinogenesis and other disease processes" and  "Over the last 50 years, tobacco refinement and the introduction of filters have brought a change in histology, and now adenocarcinoma has become the most prevalent subtype"

"Over the last decade, smoking also has emerged as a strong prognostic and predictive patient characteristic along with other variables".

Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc.

On finding a natural ingredient for the prevention and treatment of lung cancer, researchers looked into the anti-lung cancer effect of anacardic acid (AA), a constituent of the cashew nutshell.

Application of the chemical compound exerted a strong cytotoxic activity against A549 lung adenocarcinoma cells, through the expression of reactive oxidative spices.

AA also activated the proteins associated with cells apoptosis in A549 cells.

Furthermore, in the study of the efficacy of AA against cancer cells, researchers looked into the role of the expression of nuclear factor-kappaB (NF-kappaB) during the cancer inhibition.

Application of AA exerted a strong anti-cancer effect through a series of mechanisms, including induced cancer cells apoptosis by overexpression of proinflammatory cytokines correlated with the inhibition of various gene products associated with cancer cell proliferation and survival.

Moreover, the application of AA also blocked the formation of the formation of new blood vessels induced by the tumor. 

The finding suggested that AA inhibits the function of NF-κB, a protein complex in controlling the transcription of DNA, cytokine production and cell survival.

Dr. Sung B, after taking into account co and confounders said, " (There is) a novel role for anacardic acid in potentially preventing or treating cancer through modulation of the NF-kappaB signaling pathway".

Taken altogether, Anacardic acid (AA) may be used for the prevention and treatment of lung cancer, pending to the confirmation of a larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Anacardic acid induces mitochondrial-mediated apoptosis in the A549 human lung adenocarcinoma cells by Seong YA, Shin PG, Kim GD. (PubMed)
(2) Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading to potentiation of apoptosis by Sung B, Pandey MK, Ahn KS, Yi T, Chaturvedi MM, Liu M, Aggarwal BB. (PubMed)
(3) Tobacco Smoking and Lung Cancer. Perception-changing facts by Muhammad Furrukh. (PMC)

The Secondary Metabolites Berberine Reverses Polycystic Ovarian Syndrome (PCOs), Human Studies Show

By Kyle J. Norton

Scientists may have discovered a bioactive and plan base ingredient for the prevention and treatment of polycystic ovarian syndrome (PCOs) with no side effects, according to studies.

The polycystic ovarian syndrome is an endocrinologic disease caused by undeveloped follicles clumping on the ovaries that interfere with the function of the normal ovaries as resulting of enlarged ovaries.

Women with PCOs are found to produce an excessive amount of androgen, leading to a male pattern hair development, acne, irregular period or absence of period, weight gain and infertility.

The condition affects over 5% of women population or 1 in 20 women. However, the actual numbers may be substantial high because a large percentage of women in the early stage of PCOs are undiagnosed.

Some researchers suggested that women with PCOs are at a higher risk of the onset of diabetes and heart disease.

What cause PCOs? Why some women are more susceptible to the incidence and others do not even they have the same health condition and family history? No researchers can answer this question.

However, they do know according to the epidemiological studies that people who carry mutated gene inherited from the parent,  with chronic inflammatory disease and having insulin resistance are at the increased risk of PCOs.

Treatment of PCOs can vary and totally depend on the range of symptoms, or just one.

Some researchers suggested that lifestyle change may be the best for reducing the symptoms in women with PCOs. Weight loss of just 5% can lead to a significant improvement in PCOS symptoms.

Dr. Sedigheh Sedigh in the study to compare the lifestyle in women With polycystic ovary syndrome and healthy women said, "there was a significant relationship between PCOS and inappropriate diet (p=0.009), low physical activity (p=0.009), but no relationship was observed between PCOS and unhealthy behaviors".

These results clearly suggested that women who follow the Western diet with lack of exercise are associated with a substantial risk of PCOs. In other words, a change to a healthy lifestyle has a strong impact in reducing the incidence onset for women without PCOs and symptoms for women with PCOs.

Berberine is a phytochemical found in the group of protoberberine group of isoquinoline alkaloids, in many herbal plants including Oregon grape, barberry, turmeric, goldenseal, etc.

With an aim to find a natural ingredient for the treatment of the reproductive and metabolic disorder associated with insulin resistance (IR) in women with polycystic ovary syndrome (PCOS), researchers at the Harbin Medical University examine the potential therapeutic value of berberine (BBR)for PCOS.

The study included 49 wone with PCOS and IR randomized assigned into one of three treatment groups: BBR+compound cyproterone acetate (CPA; n=31), MET+CPA (n=30), and placebo+CPA (n=28) for 3 months.

After 3 months, BBR treatment group showed a decrease in waist circumference and waist-to-hip ratio (WHR; P<0.01), total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C; P<0.05) as well as increase in high-density lipoprotein cholesterol (HDLC) and sex hormone-binding globulin (SHBG) compared to MET group.

Compared to the placebo, the BBR group demonstrated a similar effect as in the comparison with the control group.

These results suggested that BBR Intake of BBR improved some of the metabolic and hormonal derangements in a group of treated Chinese women with PCOS.

Dr. Wei W, the lead author in the final report wrote, "Main effects (of BBR) could be related to the changes in body composition in obesity and dyslipidemia."

Furthermore, in order to reconfirm the effect of Berberine in PCOs subjects, researchers launched a review of the photochemical activity on polycystic ovary syndrome (PCOS) patients with insulin resistance (IR).

The search od the database of medical literature for the randomized controlled trials in human beings up to July 2018, found a total of 9 randomized controlled trials satisfied the guidelines and criteria.

 Berberine not only showed an effect in lowering blood sugar levels in db/db mice and anti-dyslipidemia inhuman.

Berberine exerted the similar effects similar to those of metformin (MET) in alleviating insulin resistance, improving glycolipid metabolism, or reproductive endocrine condition.

MET combined with BBR was not superior to MET alone, but cyproterone acetate (CPA) combined with BBR was superior to CPA alone in improving some of the reproductive endocrine indices.

The combination of BBR and Chinese herbs also showed a positive effect on all the parameters mentioned above.

Dr. Meng-Fei Li, the lead scientist, at the final report, said, "BBR showed a promising prospect in treating PCOS-IR"

Although the results indicated that Berberine has a potential effect on the treatment of metabolic and hormonal derangements in women with PCOs, due to the limitation of the studies, further data collection large example size and multi-centers studies performed with human consumption of the  bioactive compounds during the course of the disease will be necessary to complete the picture of Berberine anti PCOs possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome by Wei W, Zhao H, Wang A by Sui M, Liang K, Deng H, Ma Y, Zhang Y, Zhang H, Guan Y. (PubMed)
(2) The Effect of Berberine on Polycystic Ovary Syndrome Patients with Insulin Resistance (PCOS-IR): A Meta-Analysis and Systematic Review (Research Gate)
(3) Comparison of Lifestyle in Women With Polycystic Ovary Syndrome and Healthy Women by Sedigheh Sedighi,1 Sedigheh Amir Ali Akbari,2 Maryam Afrakhteh,3 Taraneh Esteki,4Hamid Alavi Majd,5 and Zohreh Mahmoodi. (PMC)

Avocado, the Next Prominent Anti Prostate Cancer Functional Fruit, Scientists Say

By Kyle J. Norton

Avocado may be the generation whole fruit medicine for the prevention and treatment of prostate cancer with no side effects, some scientists found

Prostate cancer is a medical condition in which the cells of the prostate has become cancerous, causing abnormal cells growth.

Most prostate cancers are slow growing and can be detected during the physical (rectum) exams.

Most cases of prostate cancer start in the cell on the surface of the inner lining of the prostate tissues.
At the advanced stage, as the tumor continues to grow, it may suppress the nearly healthy tissue and nerve cells leading to severe symptoms and pain.

According to the statistic provided by the American Cancer Society, 1 in 9 men will be diagnosed with prostate cancer during his lifetime. Approximately, 6 cases in 10 are diagnosed in men aged 65 or older.

Most common symptoms of prostate cancer include frequent urination, weak or interrupted urine flow or the need to strain to empty the bladder. and the urge to urine frequently at night due to the large size of the tumor that suppresses the bladder and the flow of urine.

Some patients may also experience symptoms blood in the urine, blood in the seminal fluid and pain or burning during urination caused by the tumor that breaks the nearby small veins and nerve cells.

At this stage, cancerous cells from the prostate gland can also travel a distance away to infect other healthy tissue and organ, leading to the secondary metastasis.

There are many risk factors associated with the onset of prostate cancer. However, the increase in age, location and behavioral correlates are some prevalent risk of the disease onset.

According to the University of Zurich, factors that may enhance prostate cancer risk include frequent consumption of dairy products and, possibly, meat and increased physical activity, intakes of tomatoes, cruciferous vegetables, and soy are possible preventative behavioral factors.

These results indicated that by following a healthy diet with moderate exercise, the risk of prostate cancer can be reduced substantially.

Avocado is commercially valuable fruit cultivated in tropical climates throughout the world. It is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.

With an aim to discover a natural ingredient or whole food for the prevention and treatment of prostate cancer with no side effects, researchers at the University of the West Indies investigate the intake of dietary MUFAs from whole fruit of avocado in the risk of prostate cancer (PCa).

The case study included 209 men 40-80 years old with newly diagnosed, histologically confirmed prostate cancer and 226 cancer-free men, attending the same urology clinics.

Higher intakes of dietary MUFA were inversely related to prostate cancer. The principal source of dietary MUFA of the participants was avocado intake. Dietary intakes of other fats were not associated with PCa.

Dr. Jackson MD, the lead author wrote in the report, "Whole-blood and dietary MUFA reduced the risk of prostate cancer. The association may be related to avocado intakes".

Researchers at the University of California agreed that the avocado is known as a rich source of monounsaturated fatty acids, for treatment of prostate cancer, but suggested that other bioactive substances including carotenoids, which might contribute to cancer preventive properties similar to those attributed to other fruits and vegetables.

In vitro, injection of acetone extract of avocado containing carotenoids and tocopherols inhibited the growth of both androgen-dependent (LNCaP) and androgen-independent (PC-3) prostate cancer cell lines.

Incubation of PC-3 cells with the avocado extract led to G(2)/M cell cycle arrest accompanied by an increase in p27 protein expression, a protein that regulates the cell cycle.

Lutein combined with other bioactive compounds also exerted a similar effect in inhibiting the prostate cancer cell spreading, but the chemical compound alone did not reproduce the effects of the avocado extract on cancer cell proliferation.

These result strongly indicated, the avocado anti-prostate cancer efficacy probably is associated with all bioactive compounds containing in the fruit such as monounsaturated fat, and carotenoids.

In order to illustrate the importance of the whole fruit in the inhibition of prostate cancer, researchers examined the 3 newly isolated compounds from unripe avocado, and found that all 3 compounds exert significant activity against six human tumor cell lines in culture and show selectivity for human prostate adenocarcinoma (PC-3) cells with 3 being nearly as potent as adriamycin.

Dr. Lu QY, after taking into account other factors said, "Because the avocado also contains a significant amount of monounsaturated fat, these bioactive carotenoids are likely to be absorbed into the bloodstream, where in combination with other diet-derived phytochemicals they may contribute to the significant cancer risk reduction associated with a diet of fruits and vegetables".

Taken altogether, avocado with abundant bioactive active compounds and MUFAs may be considered a functional fruit for the prevention and treatment of prostate cancer, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(a) Leung's Encyclopedia of Natural Ingredients: Chemical Composition of Avocado
(1) Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica by Jackson MD1, Walker SP, Simpson-Smith CM, Lindsay CM, Smith G, McFarlane-Anderson N, Bennett FI, Coard KC, Aiken WD, Tulloch T, Paul TJ, Wan RL. (PubMed)
(2) Inhibition of prostate cancer cell growth by an avocado extract: the role of lipid-soluble bioactive substances. by Lu QY1, Arteaga JR, Zhang Q, Huerta S, Go VL, Heber D.(PubMed)
(3) Cytotoxic and insecticidal constituents of the unripe fruit of Perseaamericana by Oberlies NH1, Rogers LL, Martin JM, McLaughlin JL.(PubMed)
(4) Risk factors for the onset of prostatic cancer: age, location, and behavioral correlates by Michael F Leitzmann1 and Sabine Rohrmann. (PMC)

Strawberry Effects on Human Type 1 Allergy

By Kyle J, Norton

Scientists may have found a tasty whole food for the prevention and treatment of type 1 allergy with no side effects, according to studies.

The antigen is a toxin or other foreign pathogens that induce an immune response in the body, by stimulating the production of antibodies IgE.

According to the statistic, approximately 50 million Americans each year suffer from an allergy-related disease or condition. and the syndrome is a sixth leading cause of chronic illness in the US.

Epidemiological studies suggested that people with certain medical conditions such as asthma, family history of allergy and asthma and are younger than the age of 18 are at the increased risk of allergy.

Food allergies of type I which are mediated by food-specific IgE antibodies by signaling the release of histamine from the mast cells upon the contact with the relevant allergen, causing symptoms of skin, nose, throat, and lung irritation.

The genetic proposition is also one of the prevalent risk factors for the allergic onset. Dr. Romina A. Ortiz, the lead author in the examine the genetic risk in allergic diseases, wrote, "The allergic diseases are complex phenotypes for which a strong genetic basis has been firmly established" and "A major outcome of Genome-wide association studies (GWAS) in allergic disease has been the formation of national and international collaborations leading to consortia meta-analyses, and an appreciation for the specificity of genetic associations to sub-phenotypes of allergic disease".

The genes which have a potential cause of the allergic disease include ORMDL3 locus with childhood asthma and generalizability of FLG mutations with the allergic diathesis.,...

Strawberry is a genius of Fragaria × ananassa belongs to the family Roseaceae. They have been grown all over the world with a suitable climate for commercial profits and for health benefits.

The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.

On finding potential and natural whole food for the prevention and treatment of type 1 allergy with no side effects, scientists at the Gifu University evaluated the anti-allergic activity of chemical constituents isolated from the strawberry.

Linocinnamarin (LN), 1-O-trans-cinnamoyl-beta-d-glucopyranose (CG), and cinnamic acid (CA) from the fruit were found to exert a significant effect against exhibited antigen (Ag) in stimulating the cellular process that releases antimicrobial cytotoxicity in rat basophilic leukemia RBL-2H3 cells.

On cellular responses induced by antigen stimulation, LN and CA markedly inhibited antigen-stimulated the elevation of intracellular free Ca(2+) concentration which plays an important role in T cell activation and reactive oxygen species (ROS).

The results were associated with the suppression of the Ag-stimulated spleen tyrosine kinase (Syk) activation that mediates immune receptors associated with antibody and antigen.

Further analysis of the efficacy of LN and CA, researchers discovered that the inhibition of antigen-by LN and CA is mainly due to inactivation of Syk/phospholipase Cgamma (PLCgamma) pathways which control both the innate and adaptive immune systems.

Dr. Ninomiya M, said in the final report, "LN and CA isolated from F. ananassa Duch. (strawberry) could be beneficial agents for alleviating symptoms of type I allergy".

Other bioactive compounds isolated from strawberry including isolated the 4 kinds of flavonoids from strawberry 'Nohime' also were found to exert similar effects on the cellular process that releases antimicrobial cytotoxicity in RBL-2H3 cells in the Gifu International Institute of Biotechnology study.

The found flavonoids demonstrated a strong effect on the intracellular free Ca(2+) concentration ([Ca(2+)]i) and PLCgammas similar to those of the above study.

Treatment of flavonoids also displayed a strong effect on the intracellular signaling pathway associated with the regulation of immune cell function.

Dr. Itoh T, the lead author at the end of the experiment wrote, " suppression of Ag-stimulated degranulation by the flavonoids is mainly due to suppression of [Ca(2+)]i elevation and Syk activation".

Taken altogether, strawberry, the tasty fruit processed high amounts of bioactive compounds may be considered a function fruit for the prevention and treatment of type 1 allergy with no side effects.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Genetics of Allergic Diseases by Romina A. Ortiz, MS and Kathleen C. Barnes, Ph.D. (PMC)
(2) Phenolic constituents isolated from Fragaria ananassa Duch. inhibit antigen-stimulated degranulation through direct inhibition of spleen tyrosine kinase activation by Ninomiya M, Itoh T, Ishikawa S, Saiki M, Narumiya K, Yasuda M, Koshikawa K, Nozawa Y, Koketsu M.(PubMed)
(3) Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 by Itoh T, Ninomiya M, Yasuda M, Koshikawa K, Deyashiki Y, Nozawa Y, Akao Y, Koketsu M.(PubMed)

Celery, The Functional Food Which Protects the Brian Neuron Against Alzheimer’s disease (AD)

By Kyle J. Norton

Celery may be the next generation of the natural and pharmaceutical target to discover the major ingredient for the treatment of Alzheimer's disease, some scientists suggested.

Alzheimer’s disease (AD) is a brain disorder correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer.

People who are experiencing the symptoms of mild confusion and difficulty remembering at the older age are eventually developing Alzheimer’s disease.

Although researchers do not know the exact cause of AD. However, they do know certain prevalent risk factors such as genetic proposition, unhealthy diet, and lifestyle, and environmental conditions are associated with the increased risk of Alzheimer’s disease.

According to the genetic analysis, people who carry the mutation genes associated with the autosomal-dominant AD (APP, PSEN1, PSEN2) and APOE4, affecting approximately 12 percent of the U.S. population are associated to the increased risk of the late-onset AD.

The Western diet with high in saturated and trans fat, red meat, processed foods and low in fruits and vegetables and whole grain are also the major risk factor that causes the disease due the diet in promoting insulin resistance, decreased endothelial production of nitric oxide, free radical excess, inflammatory metabolites, homocysteine, and oestrogen deficiency.

Dr. Berrino F, the researchers at the Istituto nazionale per lo studio e la cura dei tumori in the investigation of the correlation among patients with the AD and follow the Western diet before the disease onset said, "theoretically (AD) be prevented (or delayed) by relatively simple dietary measures aimed at increasing insulin sensitivity (through reduction of refined sugars and saturated fats from meat and dairy products), the ratio between n-3 and n-6 fatty acids (e.g. from fish and respectively seed oils), antioxidant vitamins, folic acid, vitamin B6, phytoestrogens (vegetables, whole cereals, and legumes, including soy products), vitamin B12 (bivalve molluscs, liver), and Cr, K, Mg, and Si salts".

These results suggested if you follow a lifestyle with moderate exercise and prevented exposure to chemical toxicity, before the disease onset you are at the substantially lower the risk of Alzheimer’s disease (AD).

Celery is a species of Apium graveolens, belonging to the family Apiaceae. It is cultivated all around the globe as a vegetable.

The veggie can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.

Researchers on the team of neurodegenerative program at the Chinese Academy of Medical Sciences and Peking Union Medical College in the reaffirm the effect of Chinese celery on neuroprotective effects showed that L-3-n-butylphthalide (L-NBP), an extract from celery seeds demonstrates a significant activity in inhibiting oxidative injury, neuronal apoptosis, and glial activation, reducing amyloid-β protein precursor (AβPP) processing and Aβ generation in rat model.

The study focuses on the neuro effect of 12 months old AβPP/PS1 mice given 15 mg/kg L-NBP by oral gavage for 3 months. 

At the end of the experiment, L-NBP treatment significantly improved the spatial learning and memory deficits, compared to the vehicle-treated AβPP/PS1 mice.

The expressions of the cyclin-dependent kinase in regulating cell cycle and glycogen synthase kinase 3β in regulating cell migration, the most important kinases involved in tau phosphorylation found abundant in neurons of the central nervous, were markedly decreased by L-NBP treatment.

These results indicated the progression of the AD in the alternation of neuron cells expression were inhibited by the application of L-NBP.

This reduction of tau phosphorylation and kinases activations caused by injection of L-NBP was observed in the biomarker of neuro-cell differentiation.

Unfortunately, the application did not exert any effect on cerebral Aβ plaque deposition and Aβ levels in brain homogenates.

Dr. Peng Y, the lead scientist wrote, " L-NBP shows promising candidate of multi-target neuronal protective agent for the treatment of Alzheimer's disease."

Further assessment of the effects of L-NBP on learning and memory in a triple-transgenic AD mouse model (3xTg-AD) that develops both plaques and tangles with aging, as well as cognitive deficits, researchers found that after Ten-month-old 3xTg-AD mice were given 15 mg/kg L-NBP by oral gavage for 18 weeks
* L-NBP treatment significantly improved learning deficits and long-term spatial memory, compared with vehicle control treatment.

* L-NBP treatment significantly reduced total cerebral Abeta plaque deposition and lowered Abeta levels in brain homogenates but had no effect on fibrillar Abeta plaques.

* L-NBP markedly enhanced soluble amyloid precursor protein secretion (alphaAPPs), alpha-secretase, and PKCalpha expression that have been known in the prevention of the molecular mechanisms underlying Alzheimer's disease (AD).

* L-NBP treatment in 3xTg-AD mice also reduced glial activation and oxidative stress compared with control treatment, an indication of AD inhibition.

These remarkable results once again, indicated that L-NBP can be promising preclinical potential as a multitarget drug for the prevention and/or treatment of Alzheimer's disease.

Taken all together, celery processed a high amount bioactive compound L-3-n-butylphthalide (L-NBP) may be considered a functional food in the prevention and combined with primary therapy for the treatment of Alzheimer's disease (AD).

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of celery anti-Alzheimer's disease possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(2) L-3-n-butylphthalide reduces tau phosphorylation and improves cognitive deficits in AβPP/PS1-Alzheimer's transgenic mice by Peng Y1, Hu Y, Xu S, Li P, Li J, Lu L, Yang H, Feng N, Wang L, Wang X.(PubMed)
(3) L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease by Peng Y1, Sun J, Hon S, Nylander AN, Xia W, Feng Y, Wang X, Lemere CA(PubMed)
(4) [Western diet and Alzheimer's disease]. [Article in Italian] by Berrino F. (PubMed)