Bilberry, The Plant and Berry That Cure Dry Eye, Scientists Discover

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have found a herbal fruit for the cure of dry eye, according to studies.

Dry eye is a condition characterized by a lack of quality tears to lubricate and nourish the eye for clear vision.

In other words, dry eye is a condition caused by an imbalance of tear production and drainage or low-quality tear production. The condition is very common in the elderly.

There are certain risk factors that may affect the levels of quality of tears, such as aging (most senior age 65 and over have experience of dry eye), gender (the risk of dry eye is higher in women due to the change of hormone as a result of pregnancy and menopause), medications and long term of use of contact lens.

According to the statistics, in the United States, dry eye affects over 4.88 million Americans age 50 and older. The syndrome is most common in the population of middle-aged or older.

Although it is rare, untreated dry eye or serious dry eye syndrome has been associated with the risk of infection, leading to scarring, thinning, and even perforation of the cornea.

People with dry eye may experience symptoms of burning or scratchy sensation, stringy mucus in the eyes, eye redness and sensitivity to light.

Some people with a severe condition may have difficulty with nighttime driving.

If you have experienced some of the aforementioned symptoms, please check with your doctor to rule out the possibility for preventive measure.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers on finding a natural ingredient for the treatment of dry eye, a chronic disease of lachrymal fluid and cornea-conjunctival epithelium examined the bioavailability of a standardized bilberry extract in an animal model.

The study included 22 otherwise healthy subjects suffering from dry eye symptoms who were enrolled randomly assigned to receive the more bioavailable bilberry extract or placebo.

Out of 22 participants,11 subjects in the bilberry extract (Mirtoselect®) group and 10 subjects in the placebo group completed the clinical study. 

According to the results of the assay analysis, bilberry extract showed a significant improvement in the volume of tear secretion compared to no change in the placebo group.

Mirtoselect® also was more effective in subjects with a higher tendency of dry eye.

The efficacy of bilberry in the treatment of dry eye was attributed to the stimulation of the production of antioxidant enzymes in the host and suppression of the overexpression of free radicals found in the dry eye participants.

Dr. Riva A the lead scientists suggested that bilberry extract can improve tear secretion and plasmatic antioxidant potential in subjects suffering from DED symptoms.

Taken altogether, bilberry processed abundantly bioactive compounds may be considered a natural remedy for the treatment of dry eye with no side effects, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) The effect of a natural, standardized bilberry extract (Mirtoselect®) in dry eye: a randomized, double blinded, placebo-controlled trial by Riva A1, Togni S, Franceschi F, Kawada S, Inaba Y, Eggenhoffner R, Giacomelli L. (PubMed)

Herbal Arctostaphylos uva-ursi, the Potential and Natural Anti Type 4 Hypersensitivity with No Side Effects, Scientists Find

By Kyle J. Norton

Scientists may have found a herbal medicine for the prevention and treatment of type 4 hypersensitivity with no side effects, according to studies.

Type 4 allergy or type 4 hypersensitivity is often called delayed-type hypersensitivity as the reaction takes several days to develop.

In other words, instead of happening right the way as that of other types, type 4 hypersensitivity typically develops at least 48 hours after exposure to an antigen. 

The process that develops type 4 hypersensitivity involved the activation of the white blood cell cells in stimulating the release of cytokines and chemokines, and macrophages and cytotoxic CD8+ T cells associated with the body's adaptive immune response.

Compared to other types of allergy mediated by theantibodyy, type 4 allergy is a cell-mediated response.

Type 4 hypersensitivity can induce allergic contact dermatitis, occurred at the site where the antigen contacts the skin, then spread to other regions through contamination of the antigen.

Type 4 hypersensitivity is caused by atopic dermatitis, lung diseases associated with hypersensitivity, type 2 diabetes and inflammation of thyroid gland.

Treatment of type 4 hypersensitivity is totally depending on the severity of the disease. however, the most appropriate approach is to avoid the offending antigen.

Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.

The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infection, kidney stone, pelvic pain, etc.

The herbal plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.

In the concern of the widespread of Type IV hypersensitivity  caused by the contact dermatitis, researchers at the Kinki University examined the combined effect of arbutin isolated from the leaves of Arctostaphylos uva-ursi (L.) Spreng. (Bearberry leaf) and indomethacin on Type IV allergic reaction-induced immuno-inflammation, carrageenin-induced edema, and adjuvant-induced arthritis.

Injection of arbutin at a dose of 50 mg/kg 24 h after the application rapidly decreased the swelling of type IV allergic sheep induced edema and adjuvant-induced arthritis by picryl chloride (PC-CD) compared to no reaction at the divided doses of 50 mg/kg.

Arbutin (p.o.) plus indomethacin (s.c.) exerted highly inhibitory effects on the swelling of PC-CD and sheep red cell delayed-type hypersensitivity (SRBC-DTH) compared to that of indomethacin alone.

Furthermore, arbutin (p.o.) and indomethacin (s.c.) in a given portion were simultaneously administered, the inhibitory effect was more potent than that of indomethacin alone in both carrageenin-induced edema and adjuvant-induced arthritis.

The results clearly suggested that arbutin may increase the inhibitory action of indomethacin on PC-CD, SRBC-DTH against type 4 hypersensitivity.

Moreover, in the comparison of water extract (UW-ext) from the leaf of Arctostaphylos uva-ursi (L.) Spreng (Bearberry leaf) on the antiallergic and anti-inflammatory activities of dexamethasone ointment, researchers found one or 2% UW-ext ointment did not inhibit the ear swelling by picryl chloride-induced contact dermatitis (PC-CD) and carrageenin-induced paw edema.

However, combined with dexamethasone ointment (0.005 or 0.025%), UW-ext augmented the inhibitory effect of dexamethasone ointment (0.005 or 0.025%) on these allergic and inflammatory models with no side effects.

These findings showed that not all parts of herbal Arctostaphylos uva-ursi processes anti-type 4 allergies, but combined with other therapy all parts augmented the significant anti-allergic and inflammatory activity with no side effects.

Additionally, the investigation of the antitype 4 allergies properties of the combined effect of 50% methanolic extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) and prednisolone also showed similar results as illustrated by the above 2 studies.

U-ext did not show an inhibitory effect on the swelling induced by PC-CD in divided doses of 100mg/kg immediately before and 16 h after the application of PC-CD, while it exhibited a significant therapeutic effect at a dose of 100 mg/kg or more once 24 h after the application.

Injection of the combination of U-ext (p.o.) and prednisolone (s.c.) simultaneously administered, exerted a greater inhibitory effect compared to that of prednisolone alone.

Researchers at the above studies wrote in the final report, "Bearberry leaf possesses a therapeutic effect against immuno-inflammation induced by PC-CD and also increases the inhibitory effect of prednisolone, and its active principle may be arbutin".

Taken altogether, herbal Herbal Arctostaphylos uva-ursi (Bearberry) may be considered a functional remedy for the prevention and combined with primary medicines for the treatment of type 4 hypersensitivity with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. V. Effect of water extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) on the antiallergic and antiinflammatory activities of dexamethasone ointment].[Article in Japanese] by Matsuda H, Nakamura S, Tanaka T, Kubo M.(PubMed)
(2) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. III. Combined effect of arbutin and indomethacin on immuno-inflammation].[Article in Japanese] by Matsuda H, Tanaka T, Kubo M.(PubMed)
(3) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. I. Combined effect of 50% methanolic extract from Arctostaphylosuva-ursi (L.) Spreng. (bearberry leaf) and prednisolone on immuno-inflammation].[Article in Japanese] by Kubo M, Ito M, Nakata H, Matsuda H.(PubMed)

Herbal Andrographis, the Renoprotective Herbal Remedy

By Kyle J. Norton

Scientists may have found a natural remedy for the prevention and treatment of chronic kidney disease with no side effects, according to studies.

The renoprotective effect is protection against anything that can cause the harm to the kidney.

Chronic kidney disease, also known as chronic kidney failure, is a condition of gradual loss of kidney function.

According to the observation of patients data associated with the diseases, diabetes and high blood pressure are responsible for up to two-thirds of the cases. 

Diabetes is a medical condition caused by long-term abnormally high blood glucose, leading to the damage of other tissue and organs, including the kidneys.

According to the statistic, approximately, 30 million American adults have chronic kidney disease, and a large percentage of these people aren't aware of it. 1 in 3 American adults is at risk for kidney disease.

Another cause of chronic kidney disease is kidney disease. Early diagnosis of chronic kidney disease can often keep chronic kidney disease from getting worse. 

Late diagnosis of chronic kidney disease may eventually lead to kidney failure, leading to dialysis or a kidney transplant to maintain life.

Some researchers suggested that improving the diet in patients with end-stage renal disease (ESRD)  can make a major difference in pathogenesis of the disease.

Dr. Chaudhary Muhammad Junaid Nazar at the Royal Gwent Hospital in the study diet and chronic kidney disease said, " During the progression of chronic kidney disease (CKD), the requirements and utilization of different nutrients change significantly" and "Understanding the applicable nutritional principles and the available methods for improving the nutritional status of these patients is important".

These results clearly suggested by improving diet may be necessary to delay the complete kidney failure and maintain the kidney function.

For patients on dialysis, diet keeps the levels of electrolytes, minerals, and fluid in the body balanced.

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.

It has been used in traditional Siddha and Ayurvedic doe the treatment of the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.

Besides the main ingredient andrographolides, giving the plant a bitter taste, other ingredients of herbal Andrographis include diterpene lactones, such as neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.

With an aim to find a natural compound or whole herb for the treatment of reno disease with no side effects, researchers examined the anti-renal failure activity of A. paniculata.
The study included Male Wistar albino rats divided into three groups: normal control, gentamicin control, and an aqueous extract of A. paniculata (200 mg/kg, per oral (p.o.))-treated.

The nephrotoxic model was induced by gentamicin (80 mg/kg, intraperitoneal (i.p.)).

After 10 days, according to the blood sample, aqueous extract of A. paniculata attenuated the gentamicin-induced increase in serum creatinine, serum urea, and blood urea nitrogen levels by 176.92%, 106.27%, and 202.90%, respectively. in a gentamicin-induced nephrotoxic animal model.

These results strongly suggested that the aqueous extract (whole plant) of A. paniculata (Burm. f.) Nees exhibits a significant renoprotective effect against the gentamicin-induced nephrotoxicity in male Wistar albino rats.

Additionally, in the comparison the renal protective effects on medical plants, researchers investigated various herbal adaptogens such as shade-dried powders of Withania somnifera, Ocimum sanctum, Asperagus recemosus, Andrographis paniculata, Asphaltum panjabinum (Shilajith), Gymnema Sylvestre, Spirulina platensis, and Panax ginseng on cadmium (Cd)-induced oxidative stress and its accumulation in broiler chicken.

A total of 80 male broiler chicks of day-old age were randomly assigned to 10 equal groups. Group 1 birds were fed with basal diet throughout the experiment (1-42 days). Group 2-10 chicks were fed with a basal diet containing cadmium at 100 ppm from day 1 to day 28 (4 weeks). From 29(th) to 42(nd) day (2 weeks), basal diet alone was fed to group 2 chicks which acted as toxic control and group 3-10 birds were fed with feed containing 0.1% powder of W. somnifera, O. sanctum, Aspe. recemosus, An. paniculata, Asph. panjabinum (Shilajith), G. Sylvestre, S. platensis, and P. ginseng, respectively.

The highest concentration of cadmium was found accumulated in kidney, in birds of group 2.

The oxidation induced the increase of thiobarbituric acid reacting substances (TBARS), and the decrease of antioxidant enzymes GSH concentrations of liver and kidney tissues in cadmium intoxicated birds were significantly reversed by the above-said herbs.

Herbal supplementation in groups 3-10 prevented Cd bioaccumulation which was most evident in the liver, followed by the kidney.

In other words, herbal Andrographis exerted a liver and kidney protective effects comparable to that of herbal medicines in the group 3, namely W. somnifera, O. sanctum, Aspe. recemosus, An. paniculata, Asph. panjabinum (Shilajith), G. Sylvestre, S. platensis, and P. ginseng, respectively.

Dr. Bharavi K, the lead scientist said in the report, "Administration of herbal adaptogens at the rate of 0.1% in feed significantly prevented the bioaccumulation of Cd and reversed the Cd-induced oxidative tissue damage".

Taken altogether, herbal Andrographis may be considered a functional remedy for the prevention of kidney damage caused by oxidative stress and reno failure and combined with the primary therapy for the treatment of kidney diseases with no side effects, pending to the confirmation of large sample size and multicenter human study.

However, intake of the herbal medicine should be prescribed by the specialists in the related field as acute kidney damage has been reported in a number of cases

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Renoprotective effects of Andrographis paniculata (Burm. f.) Nees in rats by Singh P, Srivastava MM, Khemani LD.(PubMed)
(2) Prevention of cadmium bioaccumulation by herbal adaptogens by Bharavi K, Reddy AG, Rao GS, Kumar PR, Kumar DS, Prasadini PP.(PubMed)
(3) The significance of diet in chronic kidney disease by Chaudhary Muhammad Junaid Nazar. (PMC)

Herbal Aloe Vera, the Natural Remedy for the Treatment Psoriasis

By Kyle J. Norton

Herbal Aloe vera may be a potential therapeutic remedy for the prevention and treatment of psoriasis with no side effects, scientists found.

Psoriasis is a skin condition characterized by the speeding up the life cycle of skin cells, leading to the formation of scales and red patches that are itchy and sometimes painful.

Most common causes of psoriasis is a skin infection with an autoimmune disorder caused by the immune system attacking the skin tissue after bacterial and virus invasion or skin injury due to cut or scrape, an insect bite, or a severe sunburn.

Some researchers believe that the disorder can also be driven by the change of weather, illness, or stress.

Similar to other types of inflammation, it is a result of overexpression of the inflammatory cytokines produced during the course of skin injury and damage, leading to the death and damage of the skin cells that cause of skin cells in the affected area to turn over at a significantly faster rate than normal.

Several risk factors, according to epidemiological studies such as infection, skin injury, smoking, being overweight or obese and long-term use of certain medications including beta-blockers used for the treatment of hypertension are involved in the initiation and progression of psoriasis.

Genetic preposition such as HLA-C06:02 environmental and lifestyle factors, such as certain foods and infections, are some risk factors of psoriasis.

According to statistic, these people have a 30% increased risk for the development of the condition.

Therefore, identifying the trigger potentials may be important for these patients to develop strategies the management and prevention of psoriasis.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.

The herbal plant has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.

The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

With an aim to find a natural ingredient or herbal medicine for the treatment of psoriasis, with no side effects, researchers evaluated the Aloe vera gel, used traditionally for the treatment of skin diseases, including psoriasis, through assessing the ethanolic extract of the gel in a mouse tail model of psoriasis.

The extract displayed a significant differentiation in the epidermis, as seen from its degree of orthokeratosis (85.07 ± 3.36%) when compared with the negative control (17.30 ± 4.09%).

Furthermore, the extracted gel was found to be equivalent to the effect of the standard positive control, tazarotene (0.1%) gel, which showed a 90.03 ± 2.00% degree of orthokeratosis.

Moreover, the ethanolic extract of Aloe vera leaf gel also produced a significant increase in relative epidermal thickness when compared with the control group, and no change in the standard tazarotene.

Dr. Dhanabal SP, the lead scientist said, "the extract showed an overall antipsoriatic activity of 81.95%, compared with 87.94 for tazarotene, in the mouse tail model for psoriasis".

Additionally, in the examine the topical aloe vera (AV) used to treat various skin conditions, including psoriasis, researchers launched a randomized, comparative, double-blind, 8-week study.

80 patients included in the randomized study received AV or 0.1% TA cream.

The patient's clinical responses were evaluated using the Psoriasis Area Severity Index (PASI) and the Dermatology Life Quality Index (DLQI).

After 8 weeks of treatment, researchers discovered the mean PASI score decreased from 11.6 to 3.9 (-7.7) in the AV group and from 10.9 to 4.3 (-6.6) in the TA group. Between-group difference was 1.1 (95% confidence interval -2.13, -0.16, P = 0.0237.

And, the mean DLQI score decreased from 8.6 to 2.5 (-6.1) in the AV group and from 8.1 to 2.3 (-5.8) in the TA group.

Between-group difference was 0.3 (95% confidence interval -1.18, -0.64, P = 0.5497).

In the final report, Dr. Choonhakarn C, the lead scientist wrote, "AV cream may be more effective than 0.1% TA cream in reducing the clinical symptoms of psoriasis; however, both treatments have similar efficacy in improving the quality of life of patients with mild to moderate psoriasis".

The findings suggested that herbal Aloe vera may be considered a functional remedy of the treatment of  psoriasis topically with no side effects.

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Evaluation of the antipsoriatic activity of Aloe vera leaf extract using a mouse tail model of psoriasis by Dhanabal SP, Priyanka Dwarampudi L, Muruganantham N, Vadivelan R.(PubMed)
(2) A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis by Choonhakarn C, Busaracome P, Sripanidkulchai B, Sarakarn P.(PubMed)

Sinigrin, the Potential Alternative Antibiotic for Fungal Infection, Scientists Say

By Kyle J. Norton

The bioactive compound Sinigrin may be used as antibiotics for the treatment of fungal infection, studies suggested.

Antibiotics are conventional medicine used for the treatment of microbial infection except for virus.

Fungi are kind of living organisms, including molds, molds, and mushrooms.

Most cases of fungal infections start in the lungs or on the skin. People with the weakened immune system or long-term use of antibiotics and immune suppressive medicine are prone to getting a fungal infection.

Histoplasmosis, which is the most common fungal infection in the US, caused by the dimorphic fungus Histoplasma capsulatum var. capsulatum.

However, invasive candidiasis is a common infection, approximately 46,000 cases of invasive candidiasis were diagnosed in the US each year.

Believe or not, there are millions of different fungal species on the Earth, but only about 300 of those make people sick.

Most cases of fungal infection are treated with antibiotics topically or orally.

Untreated fungal infection may cause the spread of fungi to the bloodstream, leading to serious complications including death depending on types of fungal infection.

Sinigrin is a phytochemical glucosinolate, belongs to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.

Researchers with an aim to find a natural ingredient used by traditional medicine for the treatment of fungal infection investigated the effect of sinigrin in form of isothiocyanates (ITCs)against Alternaria brassicicola.

Exposure of the fungus to ICTs led to apoptosis through the decreased oxygen consumption rate, intracellular accumulation of reactive oxygen species (ROS) and mitochondrial membrane depolarization.

The effects of fungal-induced infection on the activation of the mitogen-activated protein (MAP) kinase signaling pathway involved in directing cellular responses to a diverse array of stimuli, were inhibited by the presence of ICTs.

The injection of ICTs also induced the expression of oxygen reactive species in killing the fungi through cytotoxicity.

However,  ICT-derived ROS was also countered by the expression of different oxidative-response genes stimulated by the Alternaria brassicicola.

The findings strongly suggested that ITCs exert their toxicity on fungal cells.

Taken altogether, sinigrin in form of isothiocyanates (ITCs) may be considered a supplement for the prevention and treatment of fungal infection, pending to the confirmation of larger sample size and multicenter human study.

Intake of sinigrin as a supplement should be taken with extreme care to prevent overdose-induced liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Glucosinolate-derived isothiocyanates impact mitochondrial function in fungal cells and elicit an oxidative stress response necessary for growth recovery by Benoit Calmes,1,† Guillaume N’Guyen,1,† Jérome Dumur,1 Carlos A. Brisach,1Claire Campion,1 Béatrice Iacomi,2 Sandrine Pigné,2 Eva Dias,1 David Macherel,1Thomas Guillemette,1 and Philippe Simoneau. (PMC)

Papaya, in the Prevention and Treatment of Chronic Inflammatory Diseases

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have found a whole fruit for the prevention and treatment of chronic inflammatory diseases, according to studies.

Inflammation is a natural immune response which protects our body against the invasion of stimuli and foreign pathogens.

During the acute phase of infection, the immune first line of defense activates the protein associated with the production of blood palettes to cover the wound and inflammatory cytokines to the site of injury with an aim to prevent and kill off microorganisms.

However, overproduction of inflammatory cytokines not only can induce fever, swelling, and pain to the affected area but also damage to the nearby cells and tissue, leading to the formation of scars.

Chronic inflammatory diseases are the class of conditions involved low-grade inflammation to the affect tissue or organ. Some researchers suggested that the immune system has evolved over thousands of year to kill off the foreign invasive pathogens within a period of times, normally between 3 to 8 weeks. If the immune fails to do so, it will adapt to the new change, leading to chronic inflammation.

There are several factors that cause the onset of the conditions. Some scientists indicated untreated acute inflammation, such as an infection or injury and an autoimmune disorder involved immune system mistakenly attacking healthy tissue are the most causes of chronic inflammatory diseases.

Certain risk factors such as long-term exposure to irritants, such as industrial chemicals or polluted air, the increase in age, being obesity or obesity, low sex hormone production, sleep disorder and diet.

The Karolinska Universitetssjukhuset Solna study suggested that cigarette smoking is emerging as a strong risk factor in the otherwise unknown etiology of chronic inflammatory diseases. The risk of nicotine smokers showed a substantial increase in the risk of chronic inflammatory diseases compared to ever-nonsmokers.

Papaya is a species of Carica Papaya, belonging to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries

Chemical constituents
Alkaloids, Cardenolides, Anthraquinones, Saponins, Tannin, phenol, flavonoid, anthocyanin, Benzyl glucosinolate, benzylisothiocyanate, 5-(Hydroxymethyl)-2-furancarboxaldehyde, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and 1,3-dihydroxy-2-propanone, etc.

With an aim to investigate the therapeutic potential of fruit and vegetables in the inhibition of inflammation, with no side-effects and the whole foods additive and synergistic benefits, researchers at the Universiti Putra Malaysia, examined the role of papaya in mediating inflammatory responses.

On cells of healthy individuals, according to the flow cytometry methods, injection of the fruit significant inhibited the overexpression of IFN-γ(+), a cytokine that is critical for innate and adaptive immunity and CD4(+), in the activation of the cells of the innate immune system, B-lymphocytes, cytotoxic T cells.

The application also showed to increase the levels of anti-inflammatory cytokines which play a critical role in reducing the risk of inflammation.

These results suggested that papaya suppressed the pro-inflammatory cytokines through its anti-inflammatory response mediated through Tregs, a specialized subpopulation of T cells that act to suppress the immune response.

In other words, papaya modulates the systematic immune response through a set of mechanisms in the acute phase of infection.

Furthermore, on finding a natural ingredient or whole food for the treatment for patients with sepsis, a serious unbalanced hyperinflammatory condition, researchers evaluated the effect of mangiferin (MF), a natural glucosyl xanthone found in both mango and papaya.

Application of mangiferin (MF) was found epidemiologically to attenuate cecal ligation and puncture-induced mortality and acute lung injury (ALI), by reduced systemic and pulmonary inflammatory responses.

In Sepsis patients, pretreatment with MF inhibits sepsis-activated mitogen-activated protein kinases which play a critic role in directing cellular responses to a diverse array of stimuli, and nuclear factor kappa-light-chain-enhancer of activated B cells signaling (NF-κB) associated with the production of pro-inflammatory cytokine for cell survival.

These actions indicated that pretreatment with MF inhibits production of proinflammatory mediators associated with immune responses.

In the tested animal, MF dose-dependently exhibited the expression and activity of heme oxygenase (HO)-1, a gene which plays a critical role in the prevention of vascular inflammation. in the lung of septic mice.

Dr.Gong X, the lead scientist said, 'MF attenuates sepsis by up-regulation of HO-1 that protects against sepsis-induced ALI through inhibiting inflammatory signaling and proinflammatory mediators", after taking into account co and confounders.

Interestingly, in the evaluated fermented papaya preparation, a functional food supplement, researchers at the Touro College of Pharmacy also found that the fermentation exhibited anti-inflammatory, antioxidant, immunostimulatory (at the level of the mucous membrane), through a set of bioactive compounds found in the fruit.

Taken altogether, papaya may be considered a functional fruit for the prevention and treatment of the diseases associated with chronic inflammation.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(a) Chemical composition and bioactivity of dried fruits and honey of Ficus carica cultivars Dottato, San Francesco and Citrullara by Loizzo MR1, Bonesi M, Pugliese A, Menichini F, Tundis R.(PubMed)
(1) Carica papayaincreases regulatory T cells and reduces IFN-γ+ CD4+ T cells in healthy human subjects by Abdullah M1, Chai PS, Loh CY, Chong MY, Quay HW, Vidyadaran S, Seman Z, Kandiah M, Seow HF. (PubMed)
(2) Anti-inflammatory effects of mangiferin on sepsis-induced lung injury in mice via up-regulation of heme oxygenase-1 by Gong X1, Zhang L, Jiang R, Ye M, Yin X, Wan J.(PubMed)
(3) Applications and bioefficacy of the functional food supplement fermented papaya preparation by Aruoma OI1, Hayashi Y, Marotta F, Mantello P, Rachmilewitz E, Montagnier L.(PubMed)
(4) Smoking, use of moist snuff, and risk of chronic inflammatory diseases by Carlens C1, Hergens MP, Grunewald J, Ekbom A, Eklund A, Höglund CO, Askling J.(PubMed)

Artichoke, the Potential Anti Metabolic Syndrome Natural Remedy, According to Medical Literature

By Kyle J. Norton


Scientists may have found a natural ingredient for the treatment of metabolic syndrome with no side effect, according to studies.

A metabolic syndrome is a group of syndromes or diseases associated with an increased risk of cardiovascular disease and types 2 diabetes, including high blood pressure, sugar, cholesterol and triglyceride levels and excess body fat around the waist.

If you have 3 of the above syndrome you are considered to have metabolic syndrome.

According to statistics, metabolic syndrome is a growing prevalence of chronic conditions, accounting to 17% of all health care cost and directly contributing to the 43% of all deaths in Canada.

In other words, 1 in 5 people in Canada has metabolic syndrome, affecting 19.1% of all Canadian adults.

There are certain risk factors associated with the onset of metabolic syndrome besides the five mentioned above including age, family history of metabolic syndrome, physical activity, and women diagnosed with polycystic ovary syndrome.

Untreated metabolic syndrome epidemiologically may induce complications of chronic illness such as atherosclerosis, nonalcoholic fatty liver disease, and kidney diseases.

Some researchers suggested that metabolic syndrome and the widespread obesity in the US may be correlated as they share a hallmark of insulin resistance.

Dr. Keller KB in the differentiation of the metabolic syndrome in obese wrote, "Westernization of diets has been part of the problem. Fruits, vegetables, and whole grains are being replaced by readily accessible foods high in saturated fat, sugar, and refined carbohydrates".

And, "The metabolic syndrome associated with abdominal obesity, which includes insulin resistance, dyslipidemia, and elevated CRP levels, identifies subjects who have an increase in cardiovascular morbidity and mortality. Twenty to 25% of the adult population in the United States have the metabolic syndrome, and in some older groups this prevalence approaches 50%".

The results strongly suggested that both metabolic syndrome and obesity in the US population are attributed to the Western diet pattern.

In other words, by changing to a healthy diet such as traditional diet, the risk of obesity and metabolic syndrome can be decreased substantially.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.


Scientists on finding a natural ingredient for the treatment of metabolic syndrome examined the long-term supplementation with dietary luteolin (LU)-enriched artichoke leaf (AR) in high-fat diet (HFD)-induced obesity and its complications in C57BL/6N mice.

Selected mice were fed a normal diet, an HFD, or an HFD plus AR or LU for 16 weeks.

In the HFD-fed mice, application of AR decreased the adiposity and dyslipidemia by decreasing lipogenesis.

Moreover, AR +LU prevented insulin sensitivity by decreasing the level of plasma gastric inhibitory polypeptide and activity of hepatic glucogenic enzymes and the proteins associated with liver inflammation,

Additional analysis of the effect of AR and LU suggested, although the anti-metabolic syndrome effects of AR and LU were similar, the anti-adiposity and anti-dyslipidemic effects of AR were more pronounced.

The findings strongly support the use of artichoke for the treatment of metabolic syndrome.

In order to know more information of artichoke anti-metabolic syndrome activity, researchers evaluated the protective effect of the ethanol leaves extract of C. scolymus in alloxan induced stress oxidant, hepatic-kidney dysfunction and histological changes in liver, kidney, and pancreas of different experimental groups of rats.

The total of 40 male Wistar rats included in the study were induced to diabetes with a single dose intraperitoneal injection (i.p.) of alloxan (150 mg/kg body weight (b.w.)), then the diabetic rats were orally and daily administrated of ethanol extract from C. scolymus at two doses (200-400 mg/kg, b.w) or (12 mg/kg, b.w) with anti-diabetic reference drug, Acarbose for one month.

In vivo, injection of the ethanol extracts from the leaves of C. scolymus (200-400 mg/kg) decreased significantly, the α-amylase levels in serum of diabetic rats associated with a significant reduction in blood glucose rate of 42,84% and 37,91% after 28 days of treatment.

The extracts also induced a significant lowered of plasma total cholesterol (T-Ch) by 18,11% and triglyceride (TG) by 60,47%, low-density lipoproteins (LDL-C) by 37,77%, compared to diabetic rats.

Oxidative stress markers in the liver, kidney, and pancreas also were reduced by the injection of the extracts.

The findings suggested the anti-metabolic syndrome of artichoke was attributed to its anti-hyperglycemic properties, at least partly mediated by antioxidant and hypolipidemic effects

Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of metabolic syndrome, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Luteolin-Enriched Artichoke Leaf Extract Alleviates the Metabolic Syndrome in Mice with High-Fat Diet-Induced Obesity by Kwon EY1,2, Kim SY3, Choi MS. (PubMed)
(2) Protective effects of Cynara scolymus leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats by Ben Salem M1, Ben Abdallah Kolsi R2, Dhouibi R1, Ksouda K1, Charfi S3, Yaich M4, Hammami S1, Sahnoun Z1, Zeghal KM1, Jamoussi K4, Affes H. (PubMed)
(3) Obesity and the metabolic syndrome by Keller KB1, Lemberg L. (PubMed)