Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Wednesday, 16 January 2019

Thyme Honey, the Potential Anti Endometrial Cancer Functional Food

By Kyle J. Norton

Honey may have a significant effect on reducing risk and treatment of endometrial cancer, some scientists suggested.

Endometrial cancer is a chronic condition characterized by the irregular cell in the tissue of the endometrium.

Most cases of endometrial cancer start on the cells in the surface of the inner lining of the endometrium. At the advanced stage, after penetrating into the deeper layers, malignant cancer cells may travel a distance away to infect other healthy tissue and organs.

Endometrial cancer has been found to metastasize to the rectum, bladder, pelvic and para-aortic lymph nodes, vagina.

The exact causes of endometrial cancer are unknown. Epidemiological studies suggested that the increase in age, more years of menstruation, never been pregnant, obesity and use of hormone therapy are some the major prevalent risk factors associated with endometrial cancer.

Some researchers indicated that hormone change in the women body such as higher androgen and estrogen levels and lower levels of progesterone due to polycystic ovarian syndrome (PCOs) also is a major cause of endometrial cancer.

Dr. Navaratnarajah R, the lead author in the concern of the association of polycystic ovarian syndrome (PCOs) and the risk endometrial cancer, said, "several studies have been published that appear to support this association, and it is common practice among gynecologists and physicians to prescribe hormonal treatment to reduce this perceived risk".

"The mechanism(s) underlying any association is also unclear, but it is again widely assumed that chronic anovulation, which results in continuous estrogen stimulation of the endometrium unopposed by progesterone, is a major factor".

These result clearly state that long-term overexpression of estrogen and reduced levels of progesterone are associated with the onset of the diseases. However, the study of PCOs in the endometrial cancer risk should also be taken into accounts of obesity, hyperinsulinemia, and hyperandrogenism, which are also features of PCOS and risk factors for endometrial carcinoma.

In the association of PCOs and endometrial cancer mortality, the doctor team indicated, there is no evidence to link the increased mortality from endometrial cancer in women with the syndrome.

The study once again reaffirms the link of the estrogen therapy used in menopause women for the treatment of climate symptoms. In other words, long-term high levels of estrogen compared to progesterone in the body is the major cause of endometrial cancer.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding a natural ingredient or whole food for the prevention and treatment of endometrial cancer, researchers examined the honey influence the oestrogenic activity.

The chemical composition and the potential of Greek honey extracts (thyme, pine and fir honey) were classified to evaluate the most inhibitory activity against the endometrial cancer cells Ishikawa line.

Compared to other honey, thyme honey processes a highest total phenolics, phenolic acids, and hydroxymethylfurfural.

Thyme honey inhibited the expression of Ishikawa by reducing the cancer cells viability.

Moreover, application of thyme honey also exerted a significant effect against Ishikawa and other cancer cell lines by inhibiting the cancer cell proliferation, inducing apoptosis and cell cycle arrest.

Futhermore, the inhibition of Thyme honey also found to associated with its function in the mediation of estrogen via modulation of the estrogen receptor activity, as estrogen agonists or antagonists in cancer cell lines on a tissue type-specific manner.

The efficacy of thyme honey anti endometrial cancer was probably associated with its polyphenols and phenolic acids (vanillic acid and protocatechuic acid and p10 hydroxybenzoic acid) as these compounds have been proven to inhibit cancer-related pathways and processes

These results indicated that thyme honey monitored cell proliferation may be useful in cancer prevention, particularly, in endometrial cancer, though it's agonists/antagonists properties.

Dr. Mari Jaakkola, the lead scientist in the conclusion of the study said, " honey, especially the thyme honey, may be used as an alternative to sugar, while its incorporation in the human diet or as a food ingredient may prevent cancer-related processes, promoting thus the health of consumers".

Taken altogether, Thyme honey processed major bioactive compounds polyphenols and phenolic acids may be considered a functional food for the prevention and combined with other primary therapy for the treatment of endometrial cancer without inducing any side effects

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Bioactivity of Greek honey extracts on breast cancer (MCF7), prostate cancer (PC3) and endometrial cancer (Ishikawa) cells: Profile analysis of extracts (Research Gate) PDF
(2) Polycystic ovary syndrome and endometrial cancer by Navaratnarajah R1, Pillay OC, Hardiman P. (PubMed)

Monofloral Honey, the Potential Anti- Human immunodeficiency virus HIV-1 Functional Foods

By Kyle J. Norton

Honey may have a profound effect in reducing the risk and treatment of HIV-1, some scientists suggested.

Human immunodeficiency virus HIV-1 is the most widespread type worldwide that can lead to acquired immunodeficiency syndrome (AIDS).

Acquired immunodeficiency syndrome (AIDS) is a chronic condition caused by the infection of the human immunodeficiency virus (HIV).

According to epidemiological studies, people who serval sexual partners are the most at risk of HIV infection.

However, the virus can also transmit through infected blood transfusion, infected mother to children.

Most people infected by the HIV virus may experience symptoms of fever, muscle aches and joint pain similar to those of influenza in the early stage of the viral attacks.

At the final stage of the infection, the virus can weaken the immune system to the point that causes the onset of AIDS and induces more severe symptoms including the general symptoms of cancers accompanied by soaking night sweats, recurring fever and persistent white spots or unusual lesions on your tongue or in your mouth.

Dr. Seth C Kalichman and colleagues in the infectious team, in the concern of the risk of HIV in people with multiple sexual partners in the examining the 209 HIV positive men and 291 HIV positive women recruited conveniently from HIV/AIDS support groups and antiretroviral clinics found that 63% and 309 (62%) participants were currently sexually active, of whom 247 (80%) reported only one sex partner in the previous 3 months and 62 (20%) reported two or more partners during that time".

Although the use of a condom may have some protective effects in the prevention of HIV transmitting disease, however, the team said, "Steady sex partners of participants with multiple partnerships were significantly less likely to be protected by condoms than steady partners of individuals with only one sex partner".

Dangerously, at the final report, the team wrote, "individuals with multiple sex partners were also significantly less likely to have disclosed their HIV status".

According to the quantitative polymerase chain reaction (PCR) assay and high pure viral nucleic acid kit, 6 out of 8 monofloral kinds of honey from Petro selinum sativum, Nigella sativa, Citrus sinensis, Zataria multiflora, Citrus aurantium, and Zizyphus mauritiana flowers exerted a significantly inhibitory HIV-1 activity at different doses.

The half maximal effective concentration (EC50) values of 6 out of 8 monofloral kinds of honey are 37.5, 88, 70, 88, 105 and 5 µg/ml respectively.

The monofloral Iranian kinds of honey from Astragalus gummifer and Chamaemelum Nobile flowers had a weak anti-HIV-1 activity, compared to others.

The frequency and intensity of cluster of differentiation CD4 expression on Peripheral blood mononuclear cell (PBMC) increased in the presence of all honey types, an indication of immune activity.

Peripheral blood mononuclear cell (PBMC) are round nucleus peripheral blood cells consisted of lymphocytes (T cells, B cells, NK cells) and CD4 cells or T4 helpers play critical roles to send signals to other types of immune cells with a function to destroy invasive pathogens.

Treatment with monofloral kinds of honey from Z. multiflora and N. sativa also increased the CD19 markers for normal and neoplastic B cells.

According to the spectroscopic analysis, monofloral kinds of honey from P. sativum, N. sativa, Z. multiflora, and Z. mauritiana flowers processed a potency to be anti-HIV-1 agents.

In-depth differentiation, researchers showed that the inhibitory effect of methylglyoxal is higher on the late stage of HIV-1 infection.

The chemical compound found to exert the anti-HIV-1 activity was methylglyoxal.

Taken altogether, monofloral kinds of honey containing high amounts bioactive compound methylglyoxal may be considered a functional food for the prevention of HIV-1 infection and combined with the primary therapy for the treatment of AIDs.

Sources
(1) Anti-HIV-1 activity of eight monofloral Iranian honey types by Behbahani M1. (PubMed)
(2) Recent multiple sexual partners and HIV transmission risks among people living with HIV/AIDS in Botswana by Seth C Kalichman, Dolly Ntseane, Keitseope Nthomang, Mosarwa Segwabe, Odireleng Phorano, and Leickness C Simbayi. (PMC)

Ginger, The Natural Alternative Antibiotic for The Treatment of Parasite Infection.

By Kyle J. Norton

Ginger may be the next pharmaceutical target to identify the natural ingredient or whole food for the treatment of diseases caused by a bacterial infection, some studies found.

Infection is a medical condition caused by bacteria multiplication after entering the body.

During the acute phase of infection before the bacteria enter the body, white blood cells of the systematic immune response to the bodily injury and damage by activating not only the emergency repair system to cover the wound through coagulation but also stimulating the proteins associated with the production of proinflammatory cytokines to kill off the invaded pathogens.

However, in many instances, overproduction of proinflammatory cytokines can cause damage or death od nearby cells, leading to improper healing with the formation of scars.

In fact, failure to switch from the phase of production of proinflammatory cytokines to anti-inflammatory can interrupt the healing process, leading to chronic wound and inflammation.

Some researchers suggested that the failure of the switches may be caused by the weakened immune system that can not kill off all foreign invaders within 3 to 8 weeks.

Researcher continued, our immune system has evolved over thousands of year with an aim to kill off all stimuli and pathogens within a said of time, otherwise, they will adapt to the change, causing low-grade inflammation that cannot be reversed in many diseases such as type 2 diabetes and RA.

Most cases of acute infection were blocked in the first phase of the immune system response. In other words, the white blood cells won, pathogens were destroyed and the wound started to recover process without interruption.

However, if the pathogens won, after entering in the body, they can initiate infection through the stage of incubation where bacterial multiplying in the specific tissues and organs, leading to the colonization and in facilitating diseases development.

Patients with acute bacterial infection usually recover in a short period of time within 3 weeks.

Severely, if the immune system can not get rid of the invaders in the said time, some bacterial pathogens will establish life-long chronic infections by persistent establishment after an acute infection period.

Dr. Cierny G 3rd, the lead scientist, at the RE Orthopaedics, said," Failure of an acute inflammatory response to resolve a wound infection heralds a cascade of events that affect the host and pathogens, culminating in a chronic, refractory condition".

"The factors contributing to this outcome include immune compromise of the host, antimicrobial resistance, wound-healing deficiencies, and the adherence of pathogens to themselves and wound surfaces via an impenetrable, resistant biofilm.".

These results firmly suggested that if you have a weakened immune system you have a substantially increased risk of chronic bacterial infection.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

On finding a natural ingredient or whole food for the prevention and treatment of infection with little or no side effects researchers evaluated the effects of ginger against the monogenean parasite Gyrodactylus turnbulli.

The tested ethanolic and aqueous extracts were prepared for freeze-dried ginger.

An increase in extract concentration was associated with reduced time to parasite immobilization.

Injection at concentrations of 5 and 40ppt ethanolic extract induced parasites death at 26.1±0.7 and 4.9±0.3min, respectively. The ethanolic extract was more efficient. At 75 and 200ppt aqueous ginger extract, induced parasites died at 65.6±2.8 and 1.8±0.2min, respectively.

Bathing G. turnbulli-infected fish in the ethanolic ginger extract (i.e. 5 and 7.5ppt for 90 and 30min, respectively) significantly reduced infection prevalence and intensity.

The higher concentration (i.e. 7.5ppt) proved to be effective as those of Praziquantel, the conventional chemical.

Interestingly, oral treatments of G. turnbulli-infected guppies with diets supplemented with 10 and 20% ginger powder also proved to be ineffective in decreasing parasite load.

Furthermore, in schistosome mansonii infected mice, extract given daily for 45 days beginning at either 2nd day or 45 days post-infection showed a reduction of worm burden and the egg load in the liver and intestine which coincided with the reduction in granuloma diameters.

Ginger extract exerted a potential effect in reducing some inflammatory mediators that play a crucial role in schistosomal liver fibrosis and its complications.

The in-depth analysis also suggested that ginger extract also minimizes the deleterious effects of inflammatory and oxidative stress markers in the tested mice.

Taken altogether, ginger extracts with the abundant bioactive compound may be used for the prevention and treatment of parasite infected diseases, pending to the larger and multi-center human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Efficacy of ginger-based treatments against infection with Gyrodactylus turnbulli in the guppy (Poecilia reticulata (Peters)) by Levy G1, Zilberg D2, Paladini G1, Fridman S. (PubMed)
(2) Efficiency of ginger (Zingbar officinale) against Schistosoma mansoni infectionduring host-parasite association by Aly HF1, Mantawy MM. (PubMed)
(3) Dietary Onion or Ginger Modulates the Stress Response and Susceptibility to Vibrio harveyi JML1 Infection in Brown-marbled Grouper Epinephelus fuscoguttatus Juveniles by Amar EC1, Apines-Amar MJS2, Faisan JP Jr1. (PubMed)
(4) Treatment of chronic infection by Cierny G 3rd1, DiPasquale D. (PubMed)

Tuesday, 15 January 2019

Phytochemical Sulforaphane (Dithiolthiones) and Breast cancer, According to Studies

Kyle J. Norton

Researchers may have found a natural ingredient for the prevention and treatment of breast cancer with no side effects, according to studies.

Breast cancer is a medical condition associated with the abnormal cell growth in the breast tissue due to the alternation of cell DNA.

Most cases of the breast cancer (malignant breast neoplasm) start in the cells on the surface of the inner lining of the tissues of the breast either from the milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

At the early stage of breast cancer, most patients experience the forming of lumps or modules on the breast or nearby breast tissue.

However, at the later stage, patients may experience symptoms of swelling of all or part of a breast, breast or nipple pain, nipple retraction and large lumps on the breast.

Some invasive breast cancer in this stage can also induce secondary metastasis through the blood and fluids circulation.

According to the statistic, women diagnosed with breast cancer at stage 0 and 1 have the 5 years of the survival rate of 100%. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in the U.S. alone and the risk of getting invasive breast cancer during lifetime of a woman is 1/8.

Therefore self-examination every month may be important to all women who are classified into the higher prevalent risk group.

The causes of breast cancer are unknown. Epidemiological studies suggested that age, gender, race, family history and menstrual, l and reproductive history are some of the prevalent risk factors for breast cancer.

Some researchers suggested that risk breast cancer in women who carry the mutated genes BRCA1 and 2 have 60% for the development of breast cancer before the age of 90.

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

With an aim to find a natural ingredient for the treatment of breast cancer, researchers at the University of Michigan evaluated sulforaphane, a natural compound derived from broccoli/broccoli sprouts, efficacy in inhibiting breast cancer stem cells (CSCs) in tumor growth upon cell reimplantation in secondary mice and human breast cancer cell line.

Sulforaphane injection of (1-5 micromol/L) decreased the cancer cells by 65% to 80% in human breast cancer cells and reduced the size and number of primary mammospheres by 8- to 125-fold and 45% to 75% in tested mice, respectively.

Daily injection with 50 mg/kg sulforaphane for 2 weeks reduced breast cancer cell in the human cell line by >50%.

Sulforaphane eliminated breast CSCs in vivo, and in the secondary mice.

Furthermore, by assessing the effect of SFN alone and in combination with a chemotherapeutic agent, gemcitabine, on the proliferative potential of MCF-7 cells, researchers also found that SFN shows cytotoxic effects on MCF-7 cells in a dose- and time-dependent manner via an apoptotic mode of cell death.

A combinational treatment of SFN and gemcitabine on MCF-7 cells resulted in growth inhibition in a synergistic manner with a combination index.

The efficacy of SFN against MCF-7 was attributed to the inhibition associated with the anti-apoptotic and inflammatory gene, in a time-dependent manner, without causing harm to the nearby healthy cells.

Taken altogether, phytochemical sulforaphane may be considered a bioactive compound for the prevention and combined with primary therapy for the treatment of breast cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells by Li Y1, Zhang T, Korkaya H, Liu S, Lee HF, Newman B, Yu Y, Clouthier SG, Schwartz SJ, Wicha MS, Sun D.(PubMed)
(2) Sulforaphane inhibits growth of human breast cancer cells and augments the therapeutic index of the chemotherapeutic drug, gemcitabine by Hussain A1, Mohsin J, Prabhu SA, Begum S, Nusri Qel-A, Harish G, Javed E, Khan MA, Sharma C.(PubMed)
(3) Sulforaphane controls TPA-induced MMP-9 expression through the NF-κB signaling pathway, but not AP-1, in MCF-7 breast cancer cells by Lee YR1, Noh EM, Han JH, Kim JM, Hwang BM, Kim BS, Lee SH, Jung SH, Youn HJ, Chung EY, Kim JS.(PubMed)

Phytochemical Piperine, the Bioactive Compound May Process Anti Asthmatic Potency, Scientists Suggest

By Kyle J. Norton

Scientists may have found a natural compound for the prevention and treatment of asthma with no side effects, according to the studies.

Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing.

According to the statistics, in Canada, the number of people with asthma continues to grow. One in 12 people or 8% of the population had asthma in 2009, compared with 1 in 14 (about 20 million, or 7%) in 2001.

Asthma attacks had affected over 53% of people with asthma, compared to 57% in children in 2008.

Signs and symptoms of asthma can be triggered by airborne substances, such as pollen, dust mites, mold spores, pet dander or particles of cockroach waste. Respiratory infections, such as the common cold also be found to be the major contribution of asthma in children.

Although, researchers do not know why? people with the same health conditions in the same family, some are susceptible to the onset of asthma, while others do not. However, researchers do know, family history, race, being obese or obese, having another allergic disease, being a smoker, long-term exposure to smoking and irritable chemicals are at the increased risk of asthma development.

Dr. Mahdi Bijanzadeh, the lead scientist in the summary of " An understanding of the genetic basis of asthma" wrote, in the "Asthma is the most common chronic childhood disease in developed nations and its prevalence has increased in the world over the last 25 years. It is a complex disease with both genetic and environmental risk factors. Asthma is caused by multiple interacting genes, some having a protective effect and others contributing to the disease pathogenesis, with each gene having its own tendency to be influenced by the environment".

These results firmly suggested that people inherited a mutated gene from their parent may also be at a higher risk of the disease.

According to Medscape, the 10 genes (IL1RL1/IL18, TSLP, IL33, SMAD3, HLA-DQ, ORMDL3, IL2RB, SLC22A5, IL13, and RORA), 6 of which were confirmed by EVE investigators (IL1RL1/IL18, TSLP, IL33, SMAD3, HLA-DQ and ORMDL3).{Re9} 10 genes have been identified with strong association with the onset of asthma.

Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.

On finding a natural bioactive compound or whole food for the treatment of asthma, researchers at the JSS College of Pharmacy, Rocklands, examined the different plant extracts and phytoconstituents with the proven anti-asthmatic property.

Piper Longum L. Extract (20% Piperine) demonstrated a significant effect against human pathogens causing upper respiratory infection namely Haemophilus influenza, Streptococcus pneumonia, Streptococcus pyrogen, and Staphylococcus aureus.

Furthermore, researchers examined the effects of increasing levels of antioxidant in asthmatic patients against continued oxidative stress to determine the hypothesis of boosting the antioxidant defenses of asthma patient that could be beneficial as it may help thwart symptoms of lung disease and asthma.

The results of the experiment are astonishing.

Piper longum extracts at the same concentration of 20% piperine or piperine at 98% concentration, displayed a potent antioxidant activity by Nitric oxide radical inhibition activity method.

Dr. Nilani P, the lead scientist, after taking into account co and confounder, said, "Piper longum extract (20% Piperine),..... and piperine (98%) could be utilized in alternate anti-asthmatic therapy, since they play a vital role in scavenging Nitric oxide which could prevent the bronchial inflammation in asthmatic patients.".

The finding suggested that piperine processed anti-asthmatic property through its antioxidants and antibacterial activity.

Taken altogether, piperine may be considered a bioactive compound for the prevention and combined with the primary therapy for treatment of asthma, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effect of selected antiasthmatic plant constituents against micro organism causing upper respiratory tract infection by Nilani P, Duraisamy B, Dhamodaran P, Ravichandran S, Elango K.(PubMed)
(2) Invitro antioxidant activity of selected antiasthmatic herbal constituents by Nilani P, Kasthuribai N, Duraisamy B, Dhamodaran P, Ravichandran S, Ilango K, Suresh B.(PubMed)
(3) An understanding of the genetic basis of asthma by Mahdi Bijanzadeh, Padukudru A. Mahesh,* and Nallur B. Ramachandra. (PMC)
(4) Genetics of Asthma. Updated: Aug 05, 2015. Author: Scott T Weiss, MD, MS; Chief Editor: Karl S Roth, MD more...(Medscape)

Phytochemical Allicin, the Potent Anti Liver Cancer Bioactive Compound, According to Scientists

By Kyle J. Norton

Scientists may have found a natural compound for the prevention and treatment of liver cancer with no side effects, according to the studies.

Liver cancer is a condition caused by cell growth irregularly in the liver tissue.

Since the organ is a soft tissue with less nerve, most liver cancer patients are diagnosed in the later stage of cancer and do not experience any symptoms in the early stage.

At the advanced stage, liver cancer cells can travel a distance away to infect the healthy cells of other tissue and organs, leading secondary metastasis.

According to the statistic, liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide. In Canada, 2,500 Canadians were diagnosed with liver cancer. The disease caused 1200 death in 2017.

Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.

Besides the most common symptoms associated with all cancers, liver cancer patients may experience symptoms of abdominal swelling, jaundice, and white, chalky stools.

Although aging, gender, ethnicity, other liver diseases, hepatitis viruses, obesity is considered one the major risk factor associated with the onset of the disease.

Dr. Aleksandrova K, the lead author examined the obesity in the risk of liver cancer, said, "Non-alcoholic fatty liver disease associated with obesity, insulin resistance, and type 2 diabetes is an increasingly recognized trigger for liver cancer in Western populations characterized by low prevalence of established risk factors for liver cancer such as viral hepatitis and hepatotoxin exposure".

And, "Recent evidence has implicated several molecular pathways in obesity-associated liver cancer. These include insulin resistance leading to increased levels of insulin and insulin-like growth factors, chronic inflammation, adipose tissue remodeling, a pro-inflammatory cytokine, and adipokine secretion, and altered gut microbiota".

Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.

With an aim to find a natural compound with no side effects for the treatment of hepatocellular carcinoma (HCC) which is the most prevalent type of liver cancer globally and ranks first among the cancer-related mortalities in Taiwan, researchers examined the modes of cell death mechanism induced by allicin, a major phytochemical of crushed garlic, in human hepatoma cells.

Allicin treatment was found to induce autophagic cell death in human HCC Hep G2 (p53(wild-type)) cells.

Furthermore, allicin induced apoptotic cell death through proteins associated with pro apoptosis

Moreover, allicin activates the reactive oxygen species (ROS) overproduction to induce cytotoxicity against the human HCC Hep 3B (p53(mutation)) cells without causing harms to the nearby healthy cells.

The finding strongly suggested that allicin protects the normal through its antioxidant activity without inducing inhibition of the overexpression of free radicals.

Additionally, allicin treatment induced apoptotic cell death through gene (p53) involved cell cycle arrest similar to that of Hep 3B cells.

Dr. Chu YL, the lead scientist after taking into account co and confounders, wrote, "allicin induced cell death in human hepatoma cells through either autophagy or apoptosis".

And, "(allicin) might be a potential novel complementary gene therapeutic agent for the treatment of apoptosis-resistant cancer cells".

Taken altogether, phytochemical allicin may be considered a bioactive compound for the prevention and combined with primary medicine for the treatment of liver cancer.

References
(1) Allicin induces anti-human liver cancer cells through the p53 gene modulating apoptosis and autophagy by Chu YL, Ho CT, Chung JG, Raghu R, Lo YC, Sheen LY. (PubMed)
(2) Obesity and Liver Cancer by Aleksandrova K1, Stelmach-Mardas M2,3, Schlesinger S. (PubMed)

Monday, 14 January 2019

Bilberry, the Potential Anti Liver Cancer Herbal Remedy, According to PubMed

By Kyle J. Norton

Scientists may have found a herbal remedy for the treatment of liver cancer with no side effects, according to studies.

Liver cancer is a medical condition characterized by cell growth irregularly in the liver tissue.

The causes of liver cancer are associated with the alternation of cells DNA which normally begin in the cells on the surface of the inner lining.

Liver cancer at the early stage no not cause any symptoms. However, at the advanced stage, liver cancer cells can cause a wide range of symptoms including jaundice, abdominal swelling and pain, and dark urine and white stool accompanied by the general symptoms of cancers such as unintended weight loss, loss of appetite, chronic fatigue and tiredness and gastrointestinal discomforts.

If you experience some symptoms of the above, please make sure you check with your doctor to rule out the possibility of liver cancer.

The most common cause of liver cancer is infected by the hepatitis virus. However, in North America, due to overexpression of overweight and obese of the population, liver cancer may be slowly progressed from nonalcoholic fatty liver disease through cirrhosis to liver cancer.

There are numbers of risk factors other than those mentioned above associated with the onset of liver cancer such as male, ethnicity, hepatitis viral carriers.

However, most people with some of the above risk factors have never developed liver cancer.

Some researchers suggested that the widespread obesity may be one of the major risk factors involved the onset of the disease.

Dr. Aleksandrova K, the lead scientist in the article of obesity and liver cancer said, "Obesity and related metabolic disorders have become globally prevalent posing a challenge for the chronically damaged liver and predisposing the development and progression of cancer".

And, "Accumulating evidence has established an association between higher body mass index as an indicator of general obesity and a higher risk of primary liver cancer. The associations are stronger in men, in patients with underlying liver disease and in white ethnic groups. Abdominal obesity, weight gain in adult life and metabolic factors related to visceral fat accumulation were also suggested as important risk factors for liver cancer".

The results clearly suggested that if you are obese, your risk of liver cancer is increased substantially, compared to non-obese individuals.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Scientists on finding a natural ingredient for the treatment of liver cancer investigated the protective effect of bilberry extracts (BBE) and enzymatically modified isoquercitrin (EMIQ) on the hepatocarcinogenic process involving oxidative stress responses.

Rat selected to the study was injected to introduce the two-stage hepatocarcinogenesis in N-diethylnitrosamine-initiated and piperonyl butoxide (PBO).

Co-administration of BBE or EMIQ suppressed these effects with the reductions of GST-P(+) foci (area) to 48.9-49.4% and Ki-67(+) cells proliferation to 55.5-61.4% of the PBO-injected cases.

Neither BBE nor EMIQ alone decreased microsomal reactive oxygen species induced by PBO.

Co-administration of BBE and EMIQ decreased the incidences of phospho-PTEN(-) foci which plays a critical role in enhancing malignant proliferation and invasion abilities of liver cancer cells, to 59.8-72.2% and Smad4(-) foci to 62.4-71.5% in the promotion of liver cancer of the PBO-promoted cases.

Furthermore, injection also BBE also suppressed the incidence of phospho-Akt substrate(+) involved liver cancer cell survival to 75.2-75.7% of the PBO-promoted cases.

The finding strongly suggested that co-treatment with BBE or EMIQ suppressed cell proliferation activity of preneoplastic liver cells.

Additionally, in order to reveal more information about bilberry anti-liver cancer activity, researchers examined the anthocyanins cancer chemopreventive properties in preclinical models.

In this study, anthocyanins and their metabolites were analyzed in the urine of two patients with colorectal liver metastases.

A single dose of 1.88 g standardized bilberry extract (mirtoselect) via either nasogastric or nasojejunal tube intra-operatively during liver resection showed that there were more anthocyanins and metabolites in the urine of the patient who received mirtoselect via the stomach than via the jejunum.

These results suggested that bilberry extract (mirtoselect) via nasojejunal tube intra-operatively exerted anti-liver cancer effects without reducing the expression of anthocyanins, as the stomach is the predominant site for anthocyanin absorption.

Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of liver cancer, pending to the confirmation of large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model by Hara S1, Morita R2, Ogawa T1, Segawa R1, Takimoto N1, Suzuki K3, Hamadate N4, Hayashi SM5, Odachi A6, Ogiwara I6, Shibusawa S7, Yoshida T1, Shibutani M. (PubMed)
(2) Determination of anthocyanins in the urine of patients with colorectal liver metastases after administration of bilberry extract by Cai H1, Thomasset SC, P-Berry D, Garcea G, Brown K, Steward WP, Gescher AJ. (PubMed)
(3) Obesity and Liver Cancer by Aleksandrova K1, Stelmach-Mardas M2,3, Schlesinger S. (PubMed)