Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Tuesday, 4 December 2018

Ginger, the Kitchen Spice Which Suppresses the Onset and Progression of Rheumatoid Arthritis

By Kyle J. Norton

Ginger may have a potential effect in the prevention and treatment of rheumatoid arthritis, some scientists suggested.

Rheumatoid arthritis is a type of arthritis and chronic low-grade inflammatory disease associated with immune system mistakenly attacks the joint tissue.

According to the statistic, in the US over 1.3 million Americans were affected by rheumatoid arthritis compared to 1% of the worldwide population.

As of today, researchers do not know what trigger the immune system makes antibodies that attack the joint tissue. Why people with the same health condition in the same family, some are susceptible to the onset of the condition while others do not.

However, they do know the increase in age, family history, gender, environment, smoking, and obesity are some prevalent risk factors of RA.

In fact, lifestyle is some preventable risk factors which have been found to elevate the risk RA in the Western world.

Dr.Kathleen Chang, the lead scientist, in the study "Smoking and Rheumatoid Arthritis" clearly suggested that by following a healthy lifestyle, RA may be preventable.

The Doctor team continued " Recent developments have shed light on the pathophysiology of RA in smokers, including oxidative stress, inflammation, autoantibody formation, and epigenetic changes".

And "The association of smoking and the development of RA have been demonstrated through epidemiologic studies, as well as through in vivo and animal models of RA.

These results indicated a significant change of RA risk just by quitting cigarette smoking.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

On seeking alternative therapy for patients with chronic, painful diseases, a research team at the Basic Clin Pharmacol Toxicol investigated the potential of hydroalcoholic extract of Zingiber officinale rhizomes (Z. officinale extract) in ameliorating inflammatory process in rat rheumatoid arthritis.

Application of Z. officinale extract at the doses higher than 50 mg/kg/day intraperitoneally showed a significant effect in boosting the immune activity in rat with rheumatoid arthritis.

Continued administration for 26 days Z. officinale extract can ameliorate the clinical scores, disease incidence, joint temperature and swelling, and cartilage destruction.

The results were attributed to the extract effect in inhibiting the production of proinflammatory cytokines which play a critic role in facilitating the onset of low-grade inflammation.

The extract also reduced the immune system in the production of an antibody against the joint tissue.

Moreover, Z. officinale extract at the dose of 200 mg/kg/day was superior compared to those of 2 mg/kg/day injection of indomethacin in most of the measured parameters.

Dr. Fouda AM, at the final report, said, "These observations might make Z. officinale extract a good alternative to non-steroidal anti-inflammatory drugs for patients with rheumatoid arthritis".

In arthritis induced by a single intradermal injection of 0.1 mL of Complete Freund's adjuvant (containing heat-killed Mycobacterium tuberculosis) into the palmar surface of the left hind paw conducted by the King Faisal University, Al-Hufof, researchers examine the anti-rheumatoid arthritis in rats randomly assigned to receive orally and daily (for 28 consecutive days) distilled water as vehicle, indomethacin (1.0 mg/kg body weight), or GTaq (200 or 400 mg/kg body weight, ginger-turmeric rhizomes mixture ) from the day of arthritis induction.

Application of GTaq (especially the high dose) was more effective (4.2-38.4% higher, P < 0.05-0.001) than those of indomethacin (a non-steroidal/anti-inflammatory drug) in alleviating the loss in body weight gain, the histopathological changes in ankle joints, blood leukocytosis and thrombocytosis, iron deficiency anemia, serum hypoalbuminemia and globulinemia.

Rats treated the Gtaq also showed a reduction of the impairment of kidney functions and the risks for cardiovascular disease.

Further analysis suggested that the protective effects of GTaq are attributed to the increasing the food intake and decreasing the systemic inflammation and antioxidant activity in the inhibition of oxidative stress.

The finding supported the use of ginger-turmeric rhizomes mixture for the treatment against RA severity and complications.

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of ginger anti-rheumatoid arthritis possibilities.

Sources
(1) Zingiber officinale: A Potential Plant against Rheumatoid Arthritis by Al-Nahain A1, Jahan R2, Rahmatullah M. (PubMed)
(2) Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis by Ramadan G1, El-Menshawy O. (PubMed)
(3) Smoking and Rheumatoid Arthritis by Kathleen Chang,1 So Min Yang,2 Seong Heon Kim,3 Kyoung Hee Han,4 Se Jin Park,5 andJae Il Shin. (PubMed)

Herbal Arctostaphylos uva-ursi, Releases the Body Toxins through Kidney Urinary Secretion

By Kyle J. Norton

Scientists may have found a functional herbal medicine that process a significant effect in promoting the secretion of toxin through increasing the urinary flow, some studies suggested.

Diuretic effect is the activity of substances that promote urinary secretion.

Many diuretics medicine can interfere with the functioning kidney in the regulation the levels of water in the body, leading to worsening kidney function and abnormal electrolyte levels.

Certain medications that treat conditions of high blood pressure, glaucoma and edema can damage the kidney function by overworking the kidney in water release.

Dr. Yusra Habib Khan, the lead author in the study "Chronic Kidney Disease, Fluid Overload and Diuretics: A Complicated Triangle" said, "The use of diuretics was associated with adverse renal outcomes indicated by decline in eGFR (Glomerular filtration rate (GFR) is a measure of the function of the kidneys) and increased risk of (renal replacement therapy) RRT initiation in our cohort of NDD-CKD patients".

Therefore, intake of medicine that has a negative effect in kidney function and diuretics medicine should be taken with extreme care. If you are currently taking some of the above medicine, please make that you know the adverse effects.

Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.

The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infection, kidney stone, pelvic pain, etc.

Besides the major constituents of phenolic glycoside arbutin, tannins, and flavonoids, the herbal medicine also contains free hydroquinocoumaric acidaric acid, caffeic acid, salicylic acid, flavonoid quercetin, and triterpenes ursolic acid.

Because of increased awareness of conventional medication's side effects, there is increasing interest in the health and wellness benefits of herbs and botanicals. According to the Laboratoire de Pharmacognosie, in an animal study, Arctostaphylos uva-ursi and hydroalcoholic extracts increased urine flow. Urinary sodium excretion in rats.
Use of herbal diuresis should be taken with care and under professional prescription as the application may have a strong effect in the increase of urine flow rates to induce renal clearance of the toxicant.

In the article written by Michael E. Peterson DVM, MS, in Small Animal Toxicology (Third Edition), 2013, the author wrote, intoxications that are most likely to respond to force diuresis are those with a high level of renal excretion of the primary toxicant (e.g., bromide, lithium, amphetamine, phenobarbital, and salicylate).

Protein-bound toxins are not cleared efficiently by diuresis.

However, the patient must not be anuric or significantly oliguric

The primary problems associated with force diuresis include potential fluid overload and electrolyte abnormalities.

Michael E. Peterson DVM, MS, continued, "The practitioner should monitor for hyponatremia, hypokalemia, water intoxication, pulmonary edema, and cerebral edema. Additionally, some toxins such as tricyclic antidepressants and many sedative-hypnotics increase the patient’s susceptibility to interstitial pulmonary edema. Forced diuresis is contraindicated in these intoxications"

These results suggested that although herbal Arctostaphylos uva-ursi may be potent to detox the body toxin through increasing the urinary secretion. However, caution should be taken to prevent damage to kidney and kidney function.

Please make sure you only take the Arctostaphylos uva-ursi extract with the permission of the specialists in the related field.

However, additional data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture ofHerbal Arctostaphylos uva-ursi diuretic possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosellaL., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats BY Beaux D, Fleurentin J, Mortier F.(PubMed)
(2) Toxicologic Decontamination by Michael E. Peterson DVM, MS, in Small Animal Toxicology (Third Edition), 2013. (Science Direct)

Herbal Cayenne, the Kitchen Spice May Have Potential for Prevention and Treatment of Breast Cancer

By Kyle J. Norton, Master of Nutrition

Scientists may have found a kitchen spice which processes a potential for reducing risk and treatment of breast cancer, some studies suggested.

Breast cancer has emerged recently as a most common cancer that affects one in eight women during their lifetime in the US. The malignantly mammary cancer is characterized by the cell growth disorderly and uncontrollably first in the surface of the breast inner linings either milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma).

However, there are rare cases that breast cancer starts in other areas of the breast.

In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S.

Breast cancer diagnosed in the early was found to have 100% of the 5 years survival rate compared to stage II breast cancer of 93% and stage III breast cancers of 72%.

The exact causes of cells DNA in the breast tissue alternation are unknown. However, scientists do know that certain risk factors such as aging, family history, smoking, and dense breast tissue are associated with an increased risk of breast cancer.

Genetic mutation inherited from parents such as BRCA1 and BRCA2, tumor protein 53 or P53 and Ataxia telangiectasia mutated (ATM) accounts for 5-10 percent of all breast cancer diagnosed every year.

However, inherited mutations that cause breast cancer are rare in the general population.

An unhealthy diet such as the Western diet with high in saturated and trans fat, red meat and processed food and less in fruits and vegetables is also associated with the increased risk of breast cancer.

Dr. Stoll BA, in the assessment of the Western diet, early puberty, and breast cancer risk, explained,
"Both earlier menarche and adult tallness are markers of increased risk to breast cancer. Earlier menarche in the West is usually associated with earlier onset of hyperinsulinemia, and multiple case-control studies report that hyperinsulinemia too is a marker of increased breast cancer risk. Although the Western diet is linked both to earlier menarche and also to earlier hyperinsulinemia, the mechanism involved is not necessarily the same".

In lifestyle aspects, Dr.Harvie M, the lead author at the University Hospital of South Manchester NHS Foundation Trust, said, "Recent expert reports estimate that successful lifestyle changes could prevent 25% to 30% of cases of breast cancer".

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions.

The herbal medicine has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.

In the study to reaffirm the effect of capsaicin as an anti-breast cancer agent, Dr. Dou D at the Wayne State University School of Medicine and Barbara Ann Karmanos Cancer Center, conducted an experiment to test whether capsaicin exhibits the growth arrest and apoptosis in human breast cancer cell lines.

Although there are conflicting reports with regard to the value of hot peppers and their primary active component compound, capsaicin, as an anticancer agent, however, in vitro, breast cell growth inhibition and cell death induction was positively correlated with the capsaicin content of the peppers.

In other words, the effect of capsaicin on breast cancer proliferation and expansion are totally depending on the concentration which facilitates the production of antioxidants in the inhibition of free radical expression.

In MCF-7 cells, capsaicin was found to inhibits the cancer cell growth and induces the cancer cells on the dose-dependent manner and through reducing the levels of reactive oxygen species.

The further analysis also found that treatment of capsaicin also increased the apoptosis-inducing factor translocated into the cytosol and nucleus from the mitochondria and probably involving the pathways of caspase-independent that program breast cancer cell death

Dr. Constantinou C explained, " These pathways (pathways of caspase-independent programmed cell death (CI-PCD))are likely to be acting as 'death backup systems' that ensure effective removal of defective cells from the organism. Similar to classical apoptosis i.e. caspase-dependent programmed cell death (CD-PCD)".

Taken altogether, herbal Cayenne with high amounts of bioactive capsaicin may be considered a functional food for the prevention and treatment of breast cancer and recurrence breast cancer.

Women with a higher risk of breast cancer may want to add a small portion of chili pepper into their diet for preventive measure.

However, due to the limitation of the above studies, additional data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compound emodin during the course of the disease will be necessary to complete the picture of herbal Cayenne, anti-breast cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Tumor cell growth inhibition is correlated with levels of capsaicin present in hot peppers by Dou D, Ahmad A, Yang H, Sarkar FH. (PubMed)
(2) Caspase-independent pathways of programmed cell death: the unraveling of new targets of cancer therapy? by Constantinou C1, Papas KA, Constantinou AI. (PubMed)
(3) Dietary and Lifestyle Risk Factors for Colorectal Cancer in Apparently Healthy Adults in Jordanian Hospitals by Omran S1, Barakat H2, Muliira JK3, McMillan S. (PubMed)
(4) Can diet and lifestyle prevent breast cancer: what is the evidence? by Harvie M1, Howell A1, Evans DG. (PubMed)
(5) Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through the caspase-independent pathway by Chou CC, Wu YC, Wang YF, Chou MJ, Kuo SJ, Chen DR.(PubMed)

Herbal Anise, the Anti Breast cancer Functional Herb, Scientists Suggest

By Kyle J. Norton

The ability to cure breast cancer with a natural plant without inducing adverse effects are the dream that many scientists would hope to see in their lifetime. However, as of today, the hope is still a long way from reality.

Some studies suggested that herbal Anise may process a significant effect in the reduction of risk and treatment of breast cancer with no side effects.

Breast cancer is a medical and chronic condition characterized by abnormal cell growth in the breast tissues. Mose cases breast cancer begin with the alternation of DNA in the cells in the inner lining of the breast. After colonizing the entire breast the adance stage, malignant cancers can travel a distance away to infect other healthy cells and tissue.

The exact causes of breast cancer are unknown. researchers have tried hard but still could not answer the question, why people with the same healthy condition and genetic similarity in the same family, some are susceptible to the onset of the disease, while other female siblings do not.

Some researchers suggested the risk factors associated with breast cancer should be divided into preventable and unpreventable.

The preventable risk factors are condition can be changed through diet and lifestyle and choice, such as physical inactivity, obesity or overweight, poor diet, chest radiation, excessive alcohol drinking and use of hormone therapy.

Unpreventable risk factors are conditions that cannot be changed including the genetic opposition, age, dense breast tissue, early menstruation, and late menopause, race, and gender.

However, regardless of preventable and unpreventable risk factors associated with the onset of the disease, the risk of breast cancer is lower in women who follow a long-term healthy diet and lifestyle.

According to the National Breast cancer foundation, in all women with breast cancer, 60-70% of them have no connection to these risk factors at all, and some women with these risk factors will never develop cancer.

In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Dr. Ji Hyun Kim, the lead author in the study led by the National Cancer Center, "Dietary Factors and Female Breast Cancer Risk: A Prospective Cohort Study", said, "grilled meat and high-cholesterol food intake and irregular eating habits may be associated with a higher risk of breast cancer".

These results indicated women who follow the Western diet with high in saturated and trans fat, red meats, processed foods are associated with substantially increased risk of breast cancer compared to women, following the traditional diet pattern.

Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belonging to the family Apiaceae native to Egypt and the Mediterranean region.

The popular herb has been used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, antiseptic, anti-spasmodic, carminative, digestive, expectorant, stimulant, and tonic agent to treat head-lice and mites, increase blood pressure, prevent formation of gas in the gastrointestinal tract and menstrual cramps, etc.

Breast cancer (malignant breast neoplasm) is cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there are also rare cases that breast cancer starts in other areas of the breast.

Ingredients
Besides the main ingredient Anethole, it also contains, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

In the concerns that genomic instability, accumulative mutations, and subsequent changes in intracellular signaling cascades may influence the development of human breast cancers, researchers at the The University of Mississippi launched an investigation of the transcriptional activity of NF-kappaB measured by cell-based reporter gene assay

On epoxypseudoisoeugenol-2-methyl butyrate (EPB), a phenylpropanoid isolated from the herbal Anise exerts a significant effect in the inhibition of cell growth, cell cycle progression and apoptosis in MCF-7 (estrogen-dependent) and BT-549 (estrogen-independent) breast cancer cells, through de-activating the NF-kappaB which plays an important role in the control of transcription of DNA, cytokine production and cell survival.

EPB also found to block the proliferation of both MCF-7 and BT-549 cells in a concentration- and time-dependent manner.

The further analysis suggested that EPB induced apoptosis by cell cycle arrest in G(1)/G(0) phase in both MCF-7 and BT 549 cells.

Dr.Ma G, the lead scientist at the final report said, " in vitro results indicated that EPB has a potential for use against both hormone-dependent and hormone-independent breast cancers and its effects seem to be mediated by inhibiting the NF-kappaB activity".

In an attempt to find food components potentially acting as selective estrogen receptor modulators SERMs for treatment of breast cancer with no side effects, the University of Athens submitted four plant aqueous extracts derived from Greek flora (Sideritis Euboea, Sideritis clandestina, Matricaria chamomilla, and Pimpinella anisum) in a series of in vitro biological assays to examine their SERM profile.

All plant extracts including Anise at a concentration range 10-100 microg/mL demonstrated a potency as of SERMs in stimulating osteoblastic cell differentiation and antiestrogenic effect on breast cancer cells without proliferative effects on cervical adenocarcinoma cells.

Additionally, the antiestrogenic effect of the plant extracts was reduced under the presence of estradiol on MCF-7 cells, that suggests the extracts may process a potential estrogen receptor-related mechanism.

Taken altogether, herbal Anise may be considered a functional food for the prevention and an adjunct therapy combined with conventional medicine for treatment of breast cancer, pending on the further confirmation of large sample size and multi-center studies.

References
(1) Inhibition of NF-kappaB-mediated transcription and induction of apoptosis in human breast cancer cells by epoxypseudoisoeugenol-2-methyl butyrate by Ma G, Tabanca N, Husnu Can Baser K, Kirimer N, Pasco DS, Khan IA, Khan SI. (PubMed)
(2) Greek plant extracts exhibit selective estrogen receptor modulator (SERM)-like properties by Kassi E, Papoutsi Z, Fokialakis N, Messari I, Mitakou S, Moutsatsou P.(PubMed)
(3) Dietary Factors and Female Breast Cancer Risk: A Prospective Cohort Study by Ji Hyun Kim,1 Jeonghee Lee,2 So-Youn Jung,3 and Jeongseon Kim. (PMC)

Monday, 3 December 2018

Herbal Cat' claw, The Herb Which Balances the Levels of Free Radicals and Antioxidants in the Body

By Kyle J. Norton

Herbal Cat'claw may process a potential effect in balancing the ratio of free radicals and antioxidants in the body, some scientists suggested.

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction.

They may have positive, negative or zero charges. The unpaired electrons cause radicals to be highly chemically reactive in the human body.

Imbalance of the ratio of free radicals and antioxidants linking to the expression of oxidative stress has been associated with the onset of chronic illness, including atherosclerosis, inflammatory condition, certain cancers.
In other words, the presence of oxidative stress may be attributed to either the overexpression of free radicals generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states or reduced levels of antioxidant enzymes in the human.

In the concerns of free radicals in the expression of oxidative damage to protein and DNA, lipid peroxidation. oxidative damage to DNA, Dr. V. Lobo, the lead researcher. wrote in the study " Free radicals, antioxidants, and functional foods: Impact on human health" "A balance between free radicals and antioxidants is necessary for proper physiological function" and " Hence application of an external source of antioxidants can assist in coping this oxidative stress. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health".

The results clearly indicated, if our body can not produce the levels of antioxidant to counter the overexpression of free radicals reactive oxygen species and reactive nitrogen species, intake of antioxidants from the foods, herbs and synthetic sources may be necessary.

Some researchers also suggested that antioxidants from the food and herbal sources have been found to exert the significant effect in stimulating the antioxidants produced by the host tissue.

Cat's claw found in in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.

The herb has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc.

The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, Harman, hirsuteine, hirsutine, iso-pteropodine, etc.

In the aim to reaffirm the tradition use of Cat's claw as an anti-inflammatory disorder functional herbal medicine, researchers at the Albany Medical College, conducted an evaluation to examine the antioxidative and anti-inflammatory properties of alkaloids and flavanols isolated from the herb.

In vitro, application of alkaloids and flavanols isolated from the herb demonstrated significant anti-inflammatory activity by inhibition of TNF-alpha, the proinflammatory cytokines found in the early phase of infection and nitrite production from RAW 264.7 cells exposed to LPS (50 ng/ml) and in vivo using the indomethacin-induced gastritis model.

The IC50 value for inhibition of TNF-alpha production was significantly (P < 0.01);s higher for Uncaria tomentosa (UT) (14.1 ng/ml) vs Uncaria guianensis (UG).(9.5 ng/ml) compared to alkaloid content of Cat's claw.

Oral pretreatment for 3 d with UT protected against indomethcin-induced gastritis and prevented TNFalpha mRNA expression and apoptosis.

This demonstration reconfirms the anti-inflammatory and antioxidant activity of the herbal medicine

Furthermore, in the study to examine the ability of pteropodine to increase the antioxidant activity in mice induced oxidative stress by administered doxorubicin, researchers found that oxidative stress created by the injection of with 10 mg/kg of doxorubicin.was inhibited by pteropodine (100-600 mg/kg).

The bone marrow cytotoxicity induced by doxorubicin was also corrected by the administration of pteropodine.

In immune and antioxidant perspective, 600 mg/kg of pteropodine increased 25.8% of the production of lymphocytes over the control value along a 96-hr assay and exhibited a strong capacity to trap the DPPH-free radical (98.26% with 250 microg/ml).

Finally, in the analysis of the antioxidant properties of aqueous and ethanolic extracts of the Uncaria tomentosa bark, researchers showed that
* Both extracts process a high antioxidant capacity of the studied materials in comparison to the other extracts of fruits, vegetables, cereals, and medicinal plants.

* The alcoholic preparations exerts higher antioxidant activity and total phenolic compounds compared
Although the alcoholic preparations display a higher antioxidant potential, the highly elevated level of tannins in alcoholic extracts may cause undesirable gastric effects.

Taken altogether, Cat' claw and its extracts processed a strong antioxidant activity may be considered a functional food in the prevention of oxidative stress and combined with conventional medicine for treatment of overexpression of oxidative stress-related diseases.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content by Sandoval M1, Okuhama NN, Zhang XJ, Condezo LA, Lao J, Angeles' FM, Musah RA, Bobrowski P, Miller MJ. (PubMed)
(2) Antigenotoxic, antioxidant and lymphocyte induction effects produced by pteropodine by Paniagua-Pérez R1, Madrigal-Bujaidar E, Molina-Jasso D, Reyes-Cadena S, Alvarez-González I, Sánchez-Chapul L, Pérez-Gallaga J.(PubMed)
(3) Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC by Pilarski R1, Zieliński H, Ciesiołka D, Gulewicz K.(PubMed)
(4) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PMC)

Herbal Catnip, the Natural Insect Repellent, Scientists Suggested

By Kyle J. Norton, Master of Nutrition

Scientists may have found a natural repellent which protects our skin against insect biting without inducing any side effects, some scientists suggested.

In the rating of products that work best against mosquitoes and ticks, the consumer report found that deet (N, N-diethyl-meta-toluamide) is one of the best to protect us against mosquitoes and ticks, Any products that contain 15 to 30 percent deep can provide long-lasting protection.

However, large oral doses of deep were found to induce symptoms of nausea, vomiting, bradycardia, and seizures. In serious cases, deet can cause cardiotoxicity. Contact exposure to deet also has the potential for dermal effects, leading to numbness and redness of the applied area, according to the study "Neurotoxicity and Mode of Action of N, N-diethyl-meta-toluamide (DEET)" by Dr. Daniel R. Swale.

Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia.

The herb has bused use in herbal medicine as an insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritations stimulate sweating, promote menstruation, etc..

Ingredients
Besides the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc.

In the study to evaluate the effects herbal Catnip as an effective mosquito repellent against several Aedes and Culex species, both topically and spatially, researchers launched a study of the essential oil of the herb in laboratory bioassays.

Catnip essential oil (at a dosage of 20 mg) resulted in average repellency rates of 96% against stable flies, Stomoxys calcitrans (L.) and 79% against houseflies, Musca domestica (L.), respectively.

Catnip oil use as a potential biting and nuisance insect repellent in urban settings was a moderate irritant with non-irritating to the eye.

Dr. Zhu JJ, at the final report, said, " In comparison with other U.S. Environmental Protection Agency-approved mosquito repellents (DEET, picaridin and p-menthane-3,8-diol), catnip oil can be considered a relatively safe repellent, which may cause minor skin irritation".

Additionally, in the findings of a safer fly control strategies, researchers at the U.S. Department of Agriculture (ARS-USDA) launched an investigation of the effectiveness of catnip (Nepeta cataria L.) oil and its constituent compounds, nepetalactones, as stable fly repellents.

Injection of essential oil of catnip reduced the feeding of stable flies by >96% in an in vitro bioassay system, compared with other sesquiterpene-rich plant oils.

Catnip oil demonstrated strong repellency, compared to others chemicals for repelling biting insects, including isolongifolenone, 2-methylpiperidinyl-3-cyclohexen-1-carboxamide and (1S,2'S)-2-methylpiperidinyl-3-cyclohexen-1-carboxamide.

After taking into account of co and confounders Dr.Zhu JJ, the lead author said, " In field trials, two formulations of catnip oil provided >95% protection and were effective for up to 6 h when tested on cattle. Catnip oil also acted as a strong oviposition repellent and reduced gravid stable fly oviposition by 98%".

Taken altogether, there is no doubt that Catnip essential oil can be considered an effective insect repellent natural remedy.

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Efficacy and safety of catnip (Nepeta cataria) as a novel filth fly repellent by Zhu JJ1, Zeng XP, Berkebile D, DU HJ, Tong Y, Qian K.(PubMed)
(2) Nepetalactones from essential oil of Nepeta cataria represent a stable fly feeding and oviposition repellent by Zhu JJ1, Berkebile DR, Dunlap CA, Zhang A, Boxler D, Tangtrakulwanich K, Behle RW, Baxendale F, Brewer G.(PubMed)

Manuka Honey, the Best for Tissue Regeneration

By Kyle J. Norton

Scientists may have found a whole food which processes a significant effect in stimulating the regeneration of tissue, some study suggested.

Tissue regeneration is an act of regrowing non-injured tissues from the remaining tissue. Cells in the non-injured tissues are naturally regenerated over time by replaying the cells that have gone through certain cycle division and die.
One example is the liver grows back to its original size, though not its original shape.

However, the action totally contrasts to wound healing due to injury, involving the closing up injury site with a scar.

In fact, certain amphibians such as salamanders can regenerate lost limbs; skates, rays, and phylum Annelida, such as worms can even grow into two new, separate worms if they're cut in half.

Human, on the other hand, process very limited regeneration abilities.

According to the article "Tissue Regeneration" by Bob Hirshon wrote, "By blocking the function of just two proteins, called Rb and ARF, Blau's team was able to make mouse muscle cells regenerate like new cells"

"However, the new muscle cells merged successfully with the old cells only if the researchers turned Rb back on. If they didn't, the new cells grew too much and interfered with the function of the old muscle cells. In other words, they became tumors. And in fact, the function of both Rb and ARF in mammals is to suppress the growth of tumors".

Therefore, many works needed to be done. Dr. Vincent Falanga, the lead author in the study "Stem Cells in Tissue Repair and Regeneration" said, "We should remain hopeful that true regeneration is possible in adult human tissues. Thus far, the evidence has not been very encouraging, except for fetal wound healing" and

"We show Figure 1 to indicate the immense difficulties underlying chronic wounds. Regeneration of the tissue shown in the Figure would be extremely difficult, and would most likely first require complete removal of the non-healing and affected skin".

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding a natural ingredient and whole food processed the tissue degenerative activity without inducing any side effects, researchers at the Tehran University of Medical Sciences and Khyber Medical University evaluated the effects of Manuka honey in wound healing, epithelial regeneration.

A joint study was conducted by searching the wide spectrum sources from Google Scholar, PubMed, and Scopus.

Studies included in the investigation all suggested that Manuka honey not only processes anti carcinogenesis by controlling different molecular processes, and progression of cancer cells but also engineers the tissue regeneration.

The antibacterial property and tissue regeneration were attributed to the bioactive compound methylglyoxal (MGO) found abundantly in the honey.

After taking into account co and confounders, Dr. Niaz K wrote in the final report, "Manuka honey can enhance wound healing and tissue regeneration by their immunomodulatory property".

In order to understand the action of Manuka honey in tissue regeneration, researchers examined the effect of a scaffold electrospun based on polyurethane (PU), grape seed oil, honey, and propolis.

The prepared PU/grapeseed oil and PU/grapeseed oil/honey/propolis scaffold showed enhanced tissue regeneration through maintaining the thermal stability and reducing surface roughness compared to the control.

According to the hemolytic assay and cytocompatibility, the electrospun PU/grapeseed oil and PU/grapeseed oil/honey/propolis scaffold promoted the tissue regeneration through enhancing the red blood cells (RBC) and human fibroblast cells (HDF).

These result clearly suggested that the newly developed scaffold electrospun might be used as an alternative candidate for bone tissue engineering applications, Dr. Chao CY suggested.

Taken altogether, Manuka honey may be considered a functional food for speeding up wound healing and tissue regeneration, pending to the larger and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

(1) Health Benefits of Manuka Honey as an Essential Constituent for Tissue Regeneration by Niaz K1, Maqbool F1, Bahadar H2, Abdollahi M1.(PubMed)
(2) Engineering electrospun multicomponent polyurethane scaffolding platform comprising grapeseed oil and honey/propolis for bone tissue regeneration by Chao CY1, Mani MP2, Jaganathan SK3,4,5. (PubMed)
(2) Honey: an effective regenerative medicine product in wound management by Martinotti S1, Bucekova M2, Majtan J2, Ranzato E3. (PubMed)
(3) Tissue Regeneration by Bob Hirshon
(4) Stem Cells in Tissue Repair and Regeneration by Vincent Falanga, MD (PMC)