Herbal Cayenne, the Kitchen Spice May Have Potential for Prevention and Treatment of Breast Cancer

By Kyle J. Norton, Master of Nutrition

Scientists may have found a kitchen spice which processes a potential for reducing risk and treatment of breast cancer, some studies suggested.

Breast cancer has emerged recently as a most common cancer that affects one in eight women during their lifetime in the US. The malignantly mammary cancer is characterized by the cell growth disorderly and uncontrollably first in the surface of the breast inner linings either milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma).

However, there are rare cases that breast cancer starts in other areas of the breast.

 In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S.

Breast cancer diagnosed in the early was found to have 100% of the 5 years survival rate compared to stage II breast cancer of 93% and stage III breast cancers of 72%.

The exact causes of cells DNA in the breast tissue alternation are unknown. However, scientists do know that certain risk factors such as aging, family history, smoking, and dense breast tissue are associated with an increased risk of breast cancer.

Genetic mutation inherited from parents such as BRCA1 and BRCA2, tumor protein 53 or P53 and Ataxia telangiectasia mutated (ATM) accounts for 5-10 percent of all breast cancer diagnosed every year. 

However, inherited mutations that cause breast cancer are rare in the general population.

An unhealthy diet such as the Western diet with high in saturated and trans fat, red meat and processed food and less in fruits and vegetables is also associated with the increased risk of breast cancer.

Dr. Stoll BA, in the assessment of the Western diet, early puberty, and breast cancer risk, explained,
"Both earlier menarche and adult tallness are markers of increased risk to breast cancer. Earlier menarche in the West is usually associated with earlier onset of hyperinsulinemia, and multiple case-control studies report that hyperinsulinemia too is a marker of increased breast cancer risk. Although the Western diet is linked both to earlier menarche and also to earlier hyperinsulinemia, the mechanism involved is not necessarily the same".

In lifestyle aspects, Dr.Harvie M, the lead author at the University Hospital of South Manchester NHS Foundation Trust, said, "Recent expert reports estimate that successful lifestyle changes could prevent 25% to 30% of cases of breast cancer".

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions.

The herbal medicine has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.

In the study to reaffirm the effect of capsaicin as an anti-breast cancer agent, Dr. Dou D at the Wayne State University School of Medicine and Barbara Ann Karmanos Cancer Center, conducted an experiment to test whether capsaicin exhibits the growth arrest and apoptosis in human breast cancer cell lines.

Although there are conflicting reports with regard to the value of hot peppers and their primary active component compound, capsaicin, as an anticancer agent, however, in vitro, breast cell growth inhibition and cell death induction was positively correlated with the capsaicin content of the peppers.

In other words, the effect of capsaicin on breast cancer proliferation and expansion are totally depending on the concentration which facilitates the production of antioxidants in the inhibition of free radical expression.

In MCF-7 cells, capsaicin was found to inhibits the cancer cell growth and induces the cancer cells on the dose-dependent manner and through reducing the levels of reactive oxygen species.

The further analysis also found that treatment of capsaicin also increased the apoptosis-inducing factor translocated into the cytosol and nucleus from the mitochondria and probably involving the pathways of caspase-independent that program breast cancer cell death

Dr. Constantinou C explained, " These pathways (pathways of caspase-independent programmed cell death (CI-PCD))are likely to be acting as 'death backup systems' that ensure effective removal of defective cells from the organism. Similar to classical apoptosis i.e. caspase-dependent programmed cell death (CD-PCD)".

Taken altogether, herbal Cayenne with high amounts of bioactive capsaicin may be considered a functional food for the prevention and treatment of breast cancer and recurrence breast cancer.

Women with a higher risk of breast cancer may want to add a small portion of chili pepper into their diet for preventive measure.

However, due to the limitation of the above studies, additional data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compound emodin during the course of the disease will be necessary to complete the picture of herbal Cayenne, anti-breast cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Tumor cell growth inhibition is correlated with levels of capsaicin present in hot peppers by Dou D, Ahmad A, Yang H, Sarkar FH. (PubMed)
(2) Caspase-independent pathways of programmed cell death: the unraveling of new targets of cancer therapy? by Constantinou C1, Papas KA, Constantinou AI. (PubMed)
(3) Dietary and Lifestyle Risk Factors for Colorectal Cancer in Apparently Healthy Adults in Jordanian Hospitals by Omran S1, Barakat H2, Muliira JK3, McMillan S. (PubMed)
(4) Can diet and lifestyle prevent breast cancer: what is the evidence? by Harvie M1, Howell A1, Evans DG. (PubMed)
(5) Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through the caspase-independent pathway by Chou CC, Wu YC, Wang YF, Chou MJ, Kuo SJ, Chen DR.(PubMed)

Herbal Anise, the Anti Breast cancer Functional Herb, Scientists Suggest

By Kyle J. Norton

The ability to cure breast cancer with a natural plant without inducing adverse effects are the dream that many scientists would hope to see in their lifetime. However, as of today, the hope is still a long way from reality.

Some studies suggested that herbal Anise may process a significant effect in the reduction of risk and treatment of breast cancer with no side effects.

 Breast cancer is a medical and chronic condition characterized by abnormal cell growth in the breast tissues. Mose cases breast cancer begin with the alternation of DNA in the cells in the inner lining of the breast. After colonizing the entire breast the adance stage, malignant cancers can travel a distance away to infect other healthy cells and tissue.

The exact causes of breast cancer are unknown. researchers have tried hard but still could not answer the question, why people with the same healthy condition and genetic similarity in the same family, some are susceptible to the onset of the disease, while other female siblings do not.

Some researchers suggested the risk factors associated with breast cancer should be divided into preventable and unpreventable.

The preventable risk factors are condition can be changed through diet and lifestyle and choice, such as physical inactivity, obesity or overweight, poor diet,  chest radiation, excessive alcohol drinking and use of hormone therapy.

Unpreventable risk factors are conditions that cannot be changed including the genetic opposition, age, dense breast tissue, early menstruation, and late menopause, race, and gender.

However, regardless of preventable and unpreventable risk factors associated with the onset of the disease, the risk of breast cancer is lower in women who follow a long-term healthy diet and lifestyle.

According to the National Breast cancer foundation, in all women with breast cancer, 60-70% of them have no connection to these risk factors at all, and some women with these risk factors will never develop cancer.

In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Dr. Ji Hyun Kim, the lead author in the study led by the National Cancer Center, "Dietary Factors and Female Breast Cancer Risk: A Prospective Cohort Study", said, "grilled meat and high-cholesterol food intake and irregular eating habits may be associated with a higher risk of breast cancer". 

These results indicated women who follow the Western diet with high in saturated and trans fat, red meats, processed foods are associated with substantially increased risk of breast cancer compared to women, following the traditional diet pattern.

Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belonging to the family Apiaceae native to Egypt and the Mediterranean region.

The popular herb has been used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, antiseptic, anti-spasmodic, carminative, digestive, expectorant, stimulant, and tonic agent to treat head-lice and mites, increase blood pressure, prevent formation of gas in the gastrointestinal tract and menstrual cramps, etc.

Breast cancer (malignant breast neoplasm) is cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there are also rare cases that breast cancer starts in other areas of the breast.

Ingredients
Besides the main ingredient Anethole, it also contains, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

In the concerns that genomic instability, accumulative mutations, and subsequent changes in intracellular signaling cascades may influence the development of human breast cancers, researchers at the The University of Mississippi launched an investigation of the transcriptional activity of NF-kappaB measured by cell-based reporter gene assay

On epoxypseudoisoeugenol-2-methyl butyrate (EPB), a phenylpropanoid isolated from the herbal Anise exerts a significant effect in the inhibition of cell growth, cell cycle progression and apoptosis in MCF-7 (estrogen-dependent) and BT-549 (estrogen-independent) breast cancer cells, through de-activating the NF-kappaB which plays an important role in the control of transcription of DNA, cytokine production and cell survival.

EPB also found to block the proliferation of both MCF-7 and BT-549 cells in a concentration- and time-dependent manner. 

The further analysis suggested that EPB induced apoptosis by cell cycle arrest in G(1)/G(0) phase in both MCF-7 and BT 549 cells.

Dr.Ma G, the lead scientist at the final report said, " in vitro results indicated that EPB has a potential for use against both hormone-dependent and hormone-independent breast cancers and its effects seem to be mediated by inhibiting the NF-kappaB activity".

In an attempt to find food components potentially acting as selective estrogen receptor modulators SERMs for treatment of breast cancer with no side effects, the University of Athens submitted four plant aqueous extracts derived from Greek flora (Sideritis Euboea, Sideritis clandestina, Matricaria chamomilla, and Pimpinella anisum) in a series of in vitro biological assays to examine their SERM profile.

All plant extracts including Anise at a concentration range 10-100 microg/mL demonstrated a potency as of SERMs in stimulating osteoblastic cell differentiation and antiestrogenic effect on breast cancer cells without proliferative effects on cervical adenocarcinoma cells.

Additionally, the antiestrogenic effect of the plant extracts was reduced under the presence of estradiol on MCF-7 cells, that suggests the extracts may process a potential estrogen receptor-related mechanism. 

Taken altogether, herbal Anise may be considered a functional food for the prevention and an adjunct therapy combined with conventional medicine for treatment of breast cancer, pending on the further confirmation of large sample size and multi-center studies.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Inhibition of NF-kappaB-mediated transcription and induction of apoptosis in human breast cancer cells by epoxypseudoisoeugenol-2-methyl butyrate by Ma G, Tabanca N, Husnu Can Baser K, Kirimer N, Pasco DS, Khan IA, Khan SI. (PubMed)
(2) Greek plant extracts exhibit selective estrogen receptor modulator (SERM)-like properties by Kassi E, Papoutsi Z, Fokialakis N, Messari I, Mitakou S, Moutsatsou P.(PubMed)
(3) Dietary Factors and Female Breast Cancer Risk: A Prospective Cohort Study by Ji Hyun Kim,1 Jeonghee Lee,2 So-Youn Jung,3 and Jeongseon Kim. (PMC)

Herbal Cat' claw, The Herb Which Balances the Levels of Free Radicals and Antioxidants in the Body

By Kyle J. Norton


Herbal Cat'claw may process a potential effect in balancing the ratio of free radicals and antioxidants in the body, some scientists suggested.

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction.

They may have positive, negative or zero charges. The unpaired electrons cause radicals to be highly chemically reactive in the human body.

Imbalance of the ratio of free radicals and antioxidants linking to the expression of oxidative stress has been associated with the onset of chronic illness, including atherosclerosis, inflammatory condition, certain cancers.
In other words, the presence of oxidative stress may be attributed to either the overexpression of free radicals generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states or reduced levels of antioxidant enzymes in the human.

In the concerns of free radicals in the expression of oxidative damage to protein and DNA, lipid peroxidation. oxidative damage to DNA, Dr. V. Lobo, the lead researcher. wrote in the study " Free radicals, antioxidants, and functional foods: Impact on human health" "A balance between free radicals and antioxidants is necessary for proper physiological function" and " Hence application of an external source of antioxidants can assist in coping this oxidative stress. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health".

The results clearly indicated, if our body can not produce the levels of antioxidant to counter the overexpression of free radicals reactive oxygen species and reactive nitrogen species, intake of antioxidants from the foods, herbs and synthetic sources may be necessary.

Some researchers also suggested that antioxidants from the food and herbal sources have been found to exert the significant effect in stimulating the antioxidants produced by the host tissue.

Cat's claw found in in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.

The herb has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc.

The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, Harman, hirsuteine, hirsutine, iso-pteropodine, etc.

In the aim to reaffirm the tradition use of Cat's claw as an anti-inflammatory disorder functional herbal medicine, researchers at the Albany Medical College, conducted an evaluation to examine the antioxidative and anti-inflammatory properties of alkaloids and flavanols isolated from the herb.

In vitro, application of alkaloids and flavanols isolated from the herb demonstrated significant anti-inflammatory activity by inhibition of TNF-alpha, the proinflammatory cytokines found in the early phase of infection and nitrite production from RAW 264.7 cells exposed to LPS (50 ng/ml) and in vivo using the indomethacin-induced gastritis model.

 The IC50 value for inhibition of TNF-alpha production was significantly (P < 0.01);s higher for Uncaria tomentosa (UT) (14.1 ng/ml) vs Uncaria guianensis (UG).(9.5 ng/ml) compared to alkaloid content of Cat's claw.

Oral pretreatment for 3 d with UT protected against indomethcin-induced gastritis and prevented TNFalpha mRNA expression and apoptosis. 

This demonstration reconfirms the anti-inflammatory and antioxidant activity of the herbal medicine 

Furthermore, in the study to examine the ability of pteropodine to increase the antioxidant activity in mice induced oxidative stress by administered doxorubicin, researchers found that oxidative stress created by the injection of with 10 mg/kg of doxorubicin.was inhibited by pteropodine (100-600 mg/kg).

The bone marrow cytotoxicity induced by doxorubicin was also corrected by the administration of pteropodine.

In immune and antioxidant perspective, 600 mg/kg of pteropodine increased 25.8% of the production of lymphocytes over the control value along a 96-hr assay and exhibited a strong capacity to trap the DPPH-free radical (98.26% with 250 microg/ml).

Finally, in the analysis of the antioxidant properties of aqueous and ethanolic extracts of the Uncaria tomentosa bark, researchers showed that
* Both extracts process a high antioxidant capacity of the studied materials in comparison to the other extracts of fruits, vegetables, cereals, and medicinal plants.


* The alcoholic preparations exerts higher antioxidant activity and total phenolic compounds compared
Although the alcoholic preparations display a higher antioxidant potential, the highly elevated level of tannins in alcoholic extracts may cause undesirable gastric effects.


Taken altogether, Cat' claw and its extracts processed a strong antioxidant activity may be considered a functional food in the prevention of oxidative stress and combined with conventional medicine for treatment of overexpression of oxidative stress-related diseases.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content by Sandoval M1, Okuhama NN, Zhang XJ, Condezo LA, Lao J, Angeles' FM, Musah RA, Bobrowski P, Miller MJ. (PubMed)
(2) Antigenotoxic, antioxidant and lymphocyte induction effects produced by pteropodine by Paniagua-Pérez R1, Madrigal-Bujaidar E, Molina-Jasso D, Reyes-Cadena S, Alvarez-González I, Sánchez-Chapul L, Pérez-Gallaga J.(PubMed)
(3) Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC by Pilarski R1, Zieliński H, Ciesiołka D, Gulewicz K.(PubMed)
(4) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PMC)

Herbal Catnip, the Natural Insect Repellent, Scientists Suggested

By Kyle J. Norton, Master of Nutrition

Scientists may have found a natural repellent which protects our skin against insect biting without inducing any side effects, some scientists suggested.

In the rating of products that work best against mosquitoes and ticks, the consumer report found that deet (N, N-diethyl-meta-toluamide) is one of the best to protect us against mosquitoes and ticks, Any products that contain 15 to 30 percent deep can provide long-lasting protection.

However, large oral doses of deep were found to induce symptoms of nausea, vomiting, bradycardia, and seizures. In serious cases, deet can cause cardiotoxicity. Contact exposure to deet also has the potential for dermal effects, leading to numbness and redness of the applied area, according to the study "Neurotoxicity and Mode of Action of N, N-diethyl-meta-toluamide (DEET)" by Dr. Daniel R. Swale.

Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia.

The herb has bused use in herbal medicine as an insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritations stimulate sweating, promote menstruation, etc..

Ingredients
Besides the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc.

In the study to evaluate the effects herbal Catnip as an effective mosquito repellent against several Aedes and Culex species, both topically and spatially, researchers launched a study of the essential oil of the herb in laboratory bioassays.

Catnip essential oil (at a dosage of 20 mg) resulted in average repellency rates of 96% against stable flies, Stomoxys calcitrans (L.) and 79% against houseflies, Musca domestica (L.), respectively.

Catnip oil use as a potential biting and nuisance insect repellent in urban settings was a moderate irritant with non-irritating to the eye.

Dr. Zhu JJ, at the final report, said, " In comparison with other U.S. Environmental Protection Agency-approved mosquito repellents (DEET, picaridin and p-menthane-3,8-diol), catnip oil can be considered a relatively safe repellent, which may cause minor skin irritation".

Additionally, in the findings of a safer fly control strategies, researchers at the U.S. Department of Agriculture (ARS-USDA) launched an investigation of the effectiveness of catnip (Nepeta cataria L.) oil and its constituent compounds, nepetalactones, as stable fly repellents.

Injection of essential oil of catnip reduced the feeding of stable flies by >96% in an in vitro bioassay system, compared with other sesquiterpene-rich plant oils.

Catnip oil demonstrated strong repellency, compared to others chemicals for repelling biting insects, including isolongifolenone, 2-methylpiperidinyl-3-cyclohexen-1-carboxamide and (1S,2'S)-2-methylpiperidinyl-3-cyclohexen-1-carboxamide.

After taking into account of co and confounders Dr.Zhu JJ, the lead author said, " In field trials, two formulations of catnip oil provided >95% protection and were effective for up to 6 h when tested on cattle. Catnip oil also acted as a strong oviposition repellent and reduced gravid stable fly oviposition by 98%".

Taken altogether, there is no doubt that Catnip essential oil can be considered an effective insect repellent natural remedy. 

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Efficacy and safety of catnip (Nepeta cataria) as a novel filth fly repellent by Zhu JJ1, Zeng XP, Berkebile D, DU HJ, Tong Y, Qian K.(PubMed)
(2) Nepetalactones from essential oil of Nepeta cataria represent a stable fly feeding and oviposition repellent by Zhu JJ1, Berkebile DR, Dunlap CA, Zhang A, Boxler D, Tangtrakulwanich K, Behle RW, Baxendale F, Brewer G.(PubMed)

Manuka Honey, the Best for Tissue Regeneration

By Kyle J. Norton

Scientists may have found a whole food which processes a significant effect in stimulating the regeneration of tissue, some study suggested.

Tissue regeneration is an act of regrowing non-injured tissues from the remaining tissue. Cells in the non-injured tissues are naturally regenerated over time by replaying the cells that have gone through certain cycle division and die.
One example is the liver grows back to its original size, though not its original shape.

However, the action totally contrasts to wound healing due to injury, involving the closing up injury site with a scar.

In fact, certain amphibians such as salamanders can regenerate lost limbs; skates, rays, and phylum Annelida, such as worms can even grow into two new, separate worms if they're cut in half.

Human, on the other hand, process very limited regeneration abilities.

According to the article "Tissue Regeneration" by Bob Hirshon wrote, "By blocking the function of just two proteins, called Rb and ARF, Blau's team was able to make mouse muscle cells regenerate like new cells"

"However, the new muscle cells merged successfully with the old cells only if the researchers turned Rb back on. If they didn't, the new cells grew too much and interfered with the function of the old muscle cells. In other words, they became tumors. And in fact, the function of both Rb and ARF in mammals is to suppress the growth of tumors".

Therefore, many works needed to be done. Dr. Vincent Falanga, the lead author in the study "Stem Cells in Tissue Repair and Regeneration" said, "We should remain hopeful that true regeneration is possible in adult human tissues. Thus far, the evidence has not been very encouraging, except for fetal wound healing" and 

"We show Figure 1 to indicate the immense difficulties underlying chronic wounds. Regeneration of the tissue shown in the Figure would be extremely difficult, and would most likely first require complete removal of the non-healing and affected skin".

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding a natural ingredient and whole food processed the tissue degenerative activity without inducing any side effects, researchers at the Tehran University of Medical Sciences and Khyber Medical University evaluated the effects of Manuka honey in wound healing, epithelial regeneration.

A joint study was conducted by searching the wide spectrum sources from Google Scholar, PubMed, and Scopus.

Studies included in the investigation all suggested that Manuka honey not only processes anti carcinogenesis by controlling different molecular processes, and progression of cancer cells but also engineers the tissue regeneration. 

The antibacterial property and tissue regeneration were attributed to the bioactive compound methylglyoxal (MGO) found abundantly in the honey.

After taking into account co and confounders, Dr. Niaz K wrote in the final report, "Manuka honey can enhance wound healing and tissue regeneration by their immunomodulatory property".

In order to understand the action of Manuka honey in tissue regeneration, researchers examined the effect of a scaffold electrospun based on polyurethane (PU), grape seed oil, honey, and propolis.

The prepared PU/grapeseed oil and PU/grapeseed oil/honey/propolis scaffold showed enhanced tissue regeneration through maintaining the thermal stability and reducing surface roughness compared to the control.

According to the hemolytic assay and cytocompatibility, the electrospun PU/grapeseed oil and PU/grapeseed oil/honey/propolis scaffold promoted the tissue regeneration through enhancing the red blood cells (RBC) and human fibroblast cells (HDF).

These result clearly suggested that the newly developed scaffold electrospun might be used as an alternative candidate for bone tissue engineering applications, Dr. Chao CY suggested.

Taken altogether, Manuka honey may be considered a functional food for speeding up wound healing and tissue regeneration, pending to the larger and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

(1) Health Benefits of Manuka Honey as an Essential Constituent for Tissue Regeneration by Niaz K1, Maqbool F1, Bahadar H2, Abdollahi M1.(PubMed)
(2) Engineering electrospun multicomponent polyurethane scaffolding platform comprising grapeseed oil and honey/propolis for bone tissue regeneration by Chao CY1, Mani MP2, Jaganathan SK3,4,5. (PubMed)
(2) Honey: an effective regenerative medicine product in wound management by Martinotti S1, Bucekova M2, Majtan J2, Ranzato E3. (PubMed)
(3) Tissue Regeneration by Bob Hirshon
(4) Stem Cells in Tissue Repair and Regeneration by Vincent Falanga, MD (PMC)

Ruscogenin Isolated from Herbal Butcher's broom, the Potential Anti Acute and Chronic Inflammatory Diseases Remedy, Scientists Say

By Kyle J. Norton, Master of Nutrition

Scientists may have found a potential herbal medicine's ingredient for the treatment of acute and chronic inflammation with no side effects, some studies suggested.

Inflammation is a systematic immune response during the acute phase of infection.

Macrophages, one the lymphocytes and the first line defense of the immune system after sensing the damage of localized tissue, stimulate the production of proinflammatory cytokines to the site to protect the body against invasion of potential pathogens.

However, in some cases, overexpression of proinflammatory cytokines can cause the death of nearby healthy cells, leading to abnormal skin healing and formation of irreversible scars.

Chronic inflammation is a result of a prolonged period of inflammation that lasts for several months and even years caused by the inability of the immune system to kill off all harmful microorganisms during the acute phase of infection.

Chronic inflammation can also be caused by an autoimmune disorder in which immune system continuously attacks normal and healthy tissue, by mistaking them for the causable pathogens.

Low-grade inflammation is a different type of chronic inflammation characterized by a production of the inflammatory cytokines in a low-grade state.

Epidemiological studies, linking chronic inflammation to certain diseases such as heart disease or stroke, has been under investigation in many scientistic communities. However, as of today, scientists still do not know why people with the same health conditions and family history, some are susceptible to the onset of chronic inflammation while others do not.

If you experience some of the symptoms such as persistent body pain, fatigue, and insomnia. depression, anxiety and mood disorders, gastrointestinal complications and frequent infection. Please check with your doctor to rule out the possibility of certain diseases.

Butcher's broom is a low evergreen shrub, a species of Ruscus aculeatus, belonging to the family Asparagaceae, native to Eurasia.

The herb has been used in herbal medicine to treat reduce inflammation, Peripheral vascular disease, Hemorrhoids Bronchial asthma, Varicose veins, Hypotension, Jaundice, functional disorders of the heart, kidney disorder, venotonic and anti-oedematous properties, etc..


The chemical ingredients include rutin, sitosterol, sparteine, spirostanol saponins, steroidal sapogenins, sterols, stigmasterol, sulfated steroidal saponins, sweet broom, tetracosanoic acid, triterpenes, triterpenes, and tyramine.

In the study to reaffirm traditional Chinese medicine use of Butcher's broom for the treatment of -inflammation and thrombosis, researchers at the China Pharmaceutical University, Nanjing launched an investigation to examine the anti-inflammatory and anti-thrombotic activities of Ruscogenin (RUS), isolated from Butcher's broom.

Application of ruscogenin demonstrated a remarkably inhibited adhesion of leukocytes to a human umbilical vein endothelial cell line (ECV304) damage by the proinflammatory factor tumor necrosis factor-alpha (TNF-alpha) in a concentration-dependent manner, in vitro.

On leukocyte migration and celiac prostaglandin E(2) (PGE(2)) level induced by zymosan A in mice, injection of ruscogenin significantly suppressed zymosan A-evoked peritoneal total leukocyte migration in the initiation of inflammation, in mice in a dose-dependent manner, while the bioactive had no obvious effect on PGE(2) content in peritoneal exudate cells, participating in the forming of exudate during inflammation.

These results suggested that ruscogenin exerts a significant anti-inflammatory activity by inhibiting TNF-alpha and suppressing NF-kappaB activation in the inflammatory response during bacterial infection.

On the development of monocrotaline (MCT)-induced inflammation of pulmonary arterial hypertension (PAH). in rats, researchers found that

* Application of ruscogenin displays a strong effect on hemodynamics and pulmonary vascular inflammatory remodeling and preventing the development of PAH 3 weeks after injection of MCT.

* Ruscogenin inhibits the lung inflammation by reducing expression of inflammatory cytokine and immune leukocyte infiltration by limiting the action of nuclear factor (NF)-κB in the activation of the immune response.

Additionally, ruscogenin also restores the function of pulmonary arterioles and prevent the death of endothelial cell induced by the injection of MCT.

Taken altogether, herbal Butcher's broom processes high amounts of bioactive ingredient ruscogenin may be considered an adjunct therapy or combined with conventional medicine for treatment of acute and chronic inflammatory diseases, pending to the large example size and multi-center studies.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB by Huang YL, Kou JP, Ma L, Song JX, Yu BY. (PubMed)
(2) Ruscogenin attenuates monocrotaline-induced pulmonary hypertension in rats by Bi LQ, Zhu R, Kong H, Wu SL, Li N, Zuo XR, Zhou SM, Kou JP, Yu BY, Wang H, Xie WP. (PubMed)

Herbal Cayenne, the Anti Cancers Functional Food, Scientists Find

By Kyle J. Norton, Master of Nutrition

Scientists may have found a kitchen spice which processes a potential for reducing risk and treatment of cancers, some studies suggested.

Cancers are a class of chronic and medical conditions characterized by cells growth irregularly and disorderly.

Most cancers start on the surface of the inner lining of organ tissue. At this early stage, patients may not experience any symptoms.

At the later stage, most cancerous cells can travel a distance away from the original site to infect other healthy tissue via fluid and blood circulation.

As of today, researchers do not know the exact cause of cancer neither they know why people with the same health condition and family history, some are susceptible to DNA alternation in facilitating the onset of cancer, while others do not.

There are many prevalent risk factors associated with the cancer onset, depending on the primary location, including an increase of age, excessive alcohol consumption, exposure to chemical toxins and sunlight, and infectious pathogens.

Noticeably, in the study of "Dietary and Lifestyle Risk Factors for Colorectal Cancer in Apparently Healthy Adults in Jordanian Hospitals" conducted by the joint investigation lead by the Jordan University of Science and Technology, Dr. Omran S, the led author said, "Colorectal cancer (CRC) risk is expected to continue rising due to dietary patterns, sedentary lifestyle, and other practices" and "Data was collected using a self-report questionnaire measuring sociodemographic characteristics, dietary habits, physical activity, and lifestyle risk factors of CRC. The mean age of participants was 57.0 ± 8.56 years. The majority of participants were male (71.8 %) and with less than secondary school formal education (60.7 %). The commonest risk factors for CRC among the participants were overweight or obesity (76.1 %), lack of exercise (71.6 %), limited consumption of vegetables (70.8 %), smoking (60.6 %), over-consumption of red meat (56.3 %), and diabetes mellitus (24.1 %)".

These results suggested that by following a healthy diet with less saturated and trans fat, red meat and processed food and more in fruits and vegetables and lifestyle, the risk of cancers can be reduced substantially.

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions.

The spicy herb has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.


Chemical ingredients
The chemical constituents of Cayenne include capsaicin, capsacutin oil, solaine, xanthenes, oleic acid, palmitic acid, etc.

In the study to examine whether Capsaicin, a pungent phytochemical in a variety of red peppers processes an anti-proliferative effect on numbers of cancer, researchers at the Changhua Christian Hospital, launched an investigation of cell proliferation/viability and cytotoxicity of KB cells exposed to capsaicin.

On the human KB cancer cells, application of capsaicin exerted a significant effect in reducing cancer cell proliferation/viability and induced cell death in a dose-dependent manner compared to untreated control.d t

In cell cycle analysis, capsaicin inhibits cancer cell division n in cell cycle arrest at G2/M phase of KB cells.

Further analysis suggested that capsaicin growth inhibition of KB cells was attributed mostly in the induction of cell apoptosis, through disrupting the pathway associated with cancer cellular response in differentiation, proliferation, and survival.

Interestingly, in the concerns that diet pattern and selection may be associated with the risk of cancer onset, researchers at the Inst. of Cytology and Preventive Oncology (ICMR) launched an investigation to examine the effects of Indian diet's many unique dietary constituents, including spices like chili pepper, cloves, black pepper and black cumin on the cancers' risk.

Application of pungent spice including red pepper extract exerted a cell antiproliferative activity against the TE-13 (esophageal squamous cell carcinoma) cell line.

All extracts showed cytotoxic activity, but aqueous extracts of red pepper were found to be more potent than alcoholic extracts.

In morphological analysis, DAPI staining and DNA fragmentation assay, the aqueous extract of chili pepper at 300 μl/ml. demonstrated maximum cell death and apoptotic cell demise (88%) to occur within 24 hours compared to other pungent spicy extracts.

The finding suggested that herbal Cayenne containing a high amount of capsaicin may be considered a functional food and an adjunct therapy for reducing the risk of cancers with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Capsaicin induces cell cycle arrest and apoptosis in human KB cancercells by Lin CH, Lu WC, Wang CW, Chan YC, Chen MK. (PubMed)
(2) Cytotoxic potential of Indian spices (extracts) against esophageal squamous carcinoma cells. (PubMed)
(3) Dietary and Lifestyle Risk Factors for Colorectal Cancer in Apparently Healthy Adults in Jordanian Hospitals by Omran S1, Barakat H2, Muliira JK3, McMillan S. (PubMed)