Chaste Tree Berry (Vitex agnus-castus), in the Prevention and Treatment of Cancers

By Kyle J. Norton, Master of Nutrition


Chaste tree berry may have a potential effect in reducing risk and treatment of cancers, some studies proposed.

Cancer is the class of medical and chronic disease characterized by the irregular cells growth, that starts on the cells on the surface of the inner lining of the organ tissue.

At the later stage, the cancerous cells can travel a distance away from the original site to infect other healthy tissue through DNA alternation visa fluid and blood circulation.

The exact causes of cancer are unknown. As of today, researchers do not know why people with the same health and family history, some are susceptible to the onset of the disease while others do not.

According to the statistic provided by the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with some forms of cancer at some point during their lifetimes.

In 2017, an estimated 15,270 children and adolescents ages 0 to 19 were diagnosed with cancer, causing 1,790 death.

Epidemiologically, depending on the primary onset of the disease, the most common risk factors of cancer are aging, tobacco, sun exposure, radiation exposure, chemicals, and toxic substances, certain hormones therapy, and family history,

However, excessive alcohol, poor diet, lack of physical activity, or being overweight also are considered some major acquired risks of cancer.

Dr. Karen Basen-Engquis, the lead author in the concerns of obesity in risk of cancer wrote, "In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%.".

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region,

The queen herb has been used in herbal medicine for thousands of year as an anaphrodisiac herb. It is considered a Queen herb in treating menstrual problems and discomforts by taking it in a prolonged period of time.

There was a report that chaste tree berry stems and leaves used by women as bedding "to cool the heat of lust" during the time of the Thesmophoria.

In the findings a natural extract which proceeds anti-cancer potency, researchers at the launched an investigation to examine the anticancer extract preparation ethanol from dried ripened Vitex agnus-castus fruits growing in Israel (Vitex extract) against human uterine cervical canal fibroblast (HCF), human embryo fibroblast (HE-21), ovarian cancer (MCF-7), cervical carcinoma (SKG-3a), breast carcinoma (SKOV-3), gastric signet ring carcinoma (KATO-III), colon carcinoma (COLO 201), and small cell lung carcinoma (Lu-134-A-H) cells.

In the cell cultures, application of different concentration of Vitex extract after culture for 24 h (logarithmic growth phase) or 72 h (stationary growth phase), exerted a significant cytotoxic activity against all cell lines in logarithmic growth-phase cells, comp[ared to stationary growth-phase cells.

DNA fragmentation, an indication of cancer cells undergoing apoptosis was seen in SKOV-3, KATO-III, COLO 201, and Lu-134-A-H cells.

Furthermore, Vitex extract-treated KATO-III cells also inhibited the expression of heme oxygenase-1 and the active forms of caspases-3, -8 and -9 which play a critical role in the protection the cancer cell against cytotoxicity.

Dr. Ohyama K, the lead author, said, "(The) cytotoxic activity of Vitex extract may be attributed to the effect on cell growth, that cell death occurs through apoptosis, and that this apoptotic cell death may be attributed to increased intracellular oxidation by Vitex extract treatment".

In a human gastric signet ring carcinoma cell line, KATO-III. further analysis also suggested that application of ethanol extract of the dried ripe fruit of Vitex agnus-castus (Vitex) decrease the antioxidant enzyme produced by the cancer cells without affecting the levels of the level of GSSG, another indication of oxidative stress increased in the cancer cells.

The result indicated that, Vitex-induced apoptosis through intracellular oxidative stress and mitochondrial membrane damage through decreasing the antioxidant defense of the cancer cell lines.

Taken altogether, Chaste Tree Berry may be considered a functional food and adjunct therapy for the prevention and treatment of cancers, depending on the result of the large and multi-center studies in human consumption of the herb during the course of diseases.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth by Ohyama K1, Akaike T, Hirobe C, Yamakawa T.(PubMed)
(2) Human gastric signet ring carcinoma (KATO-III) cell apoptosis induced by Vitex agnus-castus fruit extract through intracellular oxidative stress by Ohyama K1, Akaike T, Imai M, Toyoda H, Hirobe C, Bessho T.(PubMed)
(4) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist and Maria Chang. (PMC)

Papaya, the Pharmacological Target Anti High Blood Cholesterol Functional Food

By Kyle J. Norton

Papaya may be considered a functional food of high blood cholesterol with inducing any side effects, some scientists suggested.

Cholesterol, a waxy substance produced by the liver or from the intake of dietary sources plays an important role in the building of cell membranes in transmitting information among cells and making steroid hormones, fat-soluble vitamins, and bile acids for digestive system need.

There are 2 major types of cholesterol, 

* Low-density lipoproteins (LDL) are also known as“bad” cholesterol. High levels of LDL cholesterol can block the arteries, causing heart disease. and

* High-density lipoproteins (HDL) are known as“good” cholesterol. HDL cholesterol removes bad cholesterol from other parts of your body and carries them back to the liver.

The healthy ratio of total cholesterol is 4 (bad cholesterol)/1(good cholesterol). If you total blood cholesterol is lower than 4, you are considered a have a healthy level of blood cholesterol.

The Mayo Clinic in the article talking about diet and lifestyle effect in high blood cholesterol wrote, "Poor diet. Eating saturated fat, found in animal products, and trans fats, found in some commercially baked cookies and crackers, can raise your cholesterol level. Foods that are high in cholesterol, such as red meat and full-fat dairy products, will also increase your total cholesterol".

Therefore, by change your diet pattern with more in fruits, whole grain and vegetables and less in saturated and trans fat, red meat and processed food, and following a healthy lifestyle with moderate exercise, you should be free of the syndrome of high blood cholesterol, regardless of your present conditions.

Papaya is a species of Carica Papaya, belongs to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries


Chemical constituents of papaya include
Alkaloids, Cardenolides, Anthraquinones, Saponins, Tannin, phenol, flavonoid, anthocyanin, Benzyl glucosinolate, benzylisothiocyanate, 5-(Hydroxymethyl)-2-furancarboxaldehyde, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and 1,3-dihydroxy-2-propanone, etc.

In the reaffirming of the traditional use of Ficus carica (papaya) for the treatment of several metabolic syndrome-related health problems, researchers at the University of Florida launched an investigation to examine the preventive effects of a Ficus carica (FC) leaf extract on hyperlipidemia in high-fat diet (HFD)-induced obese male rats.

Male Sprague-Dawley rats (180-200 g) were fed with a regular diet, HFD or a HFD + oral treatment of either 50 mg/kg or 100 mg/kg of FC or 30 mg/kg pioglitazone for six weeks.

At the final report, researchers found that
* Oral administration of FC exerts a significantly anti hyperlipidemia effect by lowered triglycerides (TG), interleukin-6 (IL-6) levels and elevated high-density lipoprotein cholesterol (HDL-C) in the tested animal.
* The effects of FC on lipid parameters are more pronounced in treated rats than those of the positive control pioglitazone.

* FC treatment group also significantly lowered atherogenic index (AI) and the coronary risk index (CRI). the indications of the decreased risk of atherosclerosis and coronary artery disease.

Dr. Joerin L, the lead author said, "preventive treatment with FC significantly improved the lipid profile and decreased adipogenic risk factors in HFD rats most likely mediated through an increase in HDL-C levels".

Additionally, in the evaluate the effects of the fruit and latex of papaya used in the folk medicine for treatment of hyperlipidemia, researchers conducted an experience to examine the anti-hyperlipidemic effect of the ether- and water-soluble fractions of C. papaya ethanol extract in olive oil-induced hyperlipidemic rats.

The extract and fractions were administered orally at doses of 200 and 400 mg/kg body weight in rats. Olive oil (5 mL/kg oral dose) was administered 30 min after treatment.

Oral administration of papaya extract in a dose-dependently inhibited the total cholesterol (TC), triglycerides (TG), low-density lipoproteins (LDL) level, and significantly increased high-density lipoprotein (HDL) level.

Papaya also exerted a significant acute effect on HDL level and TC and TG elevation induced by olive oil.

These results suggested that papaya extract and water fraction showed protective action by increasing the HDL cholesterol level and lowering the levels of HDL level and TC and TG elevation in hyperlipidemic rats.

Taken all together, papaya may be considered a functional food for treatment of high blood cholesterol.

However, due to the limitation of the above studies, additional data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of papaya antihyperlipidemic possibility.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Chemical composition and bioactivity of dried fruits and honey of Ficus carica cultivars Dottato, San Francesco and Citrullara by Loizzo MR1, Bonesi M, Pugliese A, Menichini F, Tundis R.(PubMed)
(2) Ficus carica leaf extract modulates the lipid profile of rats fed with a high-fat diet through an increase of HDL-C by Joerin L1, Kauschka M, Bonnländer B, Pischel I, Benedek B, Butterweck V.(PubMed)
(3) Effect of ether- and water-soluble fractions of Carica papaya ethanol extract in experimentally induced hyperlipidemia in rats by Iyer D1, Sharma BK, Patil UK. (PubMed)

Banana, the Potent Anti Diabetes Functional Food

By Kyle J. Norton

Unripe banana may be considered a functional for the prevention and treatment of diabetes, some scientists suggested.

Diabetes is a medical and condition characterized by insufficient insulin entering the bloodstream to regulate the glucose as the results of either cell in pancreas dying off or receptor sites clogged up by fat and cholesterol.

In some cases, diabetes is also caused by allergic reactions of cells in the immune system or immune 

system mistakenly attacks the cells which produce insulin, leading to insulin resistance.

The death of beta cells in the pancreas is triggered by massive overproduction of short strands of ribonucleic acid, known as microRNA (miR) 200. These result suggested that blocking miR-200 may guarantee the survival of beta cells, even ones under extreme stress.

In case of pancreas clogged up with fat accumulation, some researchers found that losing less than one gram of that fat through weight loss reverses diabetes.

Professor Taylor of Newcastle University said, “So if you ask how much weight you need to lose to make your diabetes go away, the answer is one gram! But that gram needs to be far from the pancreas. At present, the only way we have to achieve this is by calorie restriction by any means – whether by diet or an operation.

”In patients who had started with Type 2 diabetes, fat levels in the pancreas (pancreatic triglyceride) decreased by 1.2% over the 8 weeks. Very exact methods were needed to be able to measure this and a new method using a special MRI scan was developed. With an average pancreas for a person with Type 2 diabetes having a volume of 50 ml, this is the equivalent of around 0.6 grams of fat.

According to the study by ETH Zurich and the International Diabetes Foundation, there are over 380 million diabetics around the world. Approximately,  by the year 2030, over half a billion people will be suffering from type 2 diabetes. 

Banana is the common name of a genus of tropical herbaceous plants. It can grow from 3 to 9 m and belonging to the family of the lily and the orchid. 

In the study to reaffirming of the traditional use of banana for treatment of diabetes in India, researchers at the University College of Medical Sciences, Dilshad Garden launched an investigation to assess the antidiabetic and antihyperlipidemic effects of the stem of the banana. In the experiment, diabetes was induced in rats by streptozotocin injection (45 mg/kg, i.p.). Diabetic rats were treated for 2 weeks with different doses of lyophilized stem juice of banana. (25, 50, and 100 mg/kg) to select the most effective dose.

* The most effective dose of lyophilized stem juice of M. sapientum Linn (Banana) was 50 mg/kg.

* The four weeks treatment with this dose resulted in significant decreases in fasting and postprandial plasma glucose (FPG, PPG) levels.

* Serum insulin increased (P < 0.05) whereas HbA1c decreased (P < 0.05).

* Diabetes-induced changes to the lipid profile, muscle and liver glycogen, and enzyme activity (i.e. glucokinase, glucose-6-phosphatase, and HMG-CoA reductase) were restored near to normal levels by the application of banana.

These results suggested that lyophilized stem juice of banana (M. sapientum Linn) exhibits antidiabetic and antihyperlipidemic effects.

Furthermore, in the study to find out the mechanism of hypoglycemic effect by ethanol extract of banana pseudostem (EE) researchers suggested
* The ethanol extract of banana significantly inhibited mammalian intestinal α-glucosidases and yeast α-glucosidase.

* Oral administration (100-200 mg kg(-1) body weight) of EE significantly suppressed the maltose/glucose-induced postprandial plasma glucose elevation and wielded an antihyperglycaemic effect in normal and alloxan-induced diabetic rats. 

Dr. Ramu R, the lead scientist said, "EE might exert an anti-diabetic effect by inhibition of α-glucosidases from the intestine, in turn suppressing the carbohydrate absorption into the bloodstream. Hence the results extend a foundation for the future prospects of the food-derived enzyme inhibitors in the treatment of diabetes".

Additionally, according to the Central Food Technological Research Institute, banana flower and pseudostem have a low glycemic index and have a high content of dietary fiber and antioxidants.

Application fo the flower and pseudostem showed to inhibit diabetic symptoms like hyperglycemia, polyuria, polyphagia, polydipsia, urine sugar, and body weight in the rat model.

Taken all together, unripe banana may be used as a functional food for the prevention and combined with primary therapy for treatment of diabetes in the human,  depending on the confirmation of further data collection from the large example size and multi-center studies.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Antidiabetic and antihyperlipidemic effects of the stem of Musasapientum Linn. in streptozotocin-induced diabetic rats by Dikshit P1, Shukla K, Tyagi MK, Garg P, Gambhir JK, Shukla R.(PubMed)
(2) Investigation of antihyperglycaemic activity of banana (Musa sp. var. Nanjangud rasa bale) pseudostem in normal and diabetic rats by Ramu R1, Shirahatti PS, Zameer F, Nagendra Prasad MN. (PubMed).
(3) Beneficial effects of banana (Musa sp. var. elakki bale) flower and pseudostem on hyperglycemia and advanced glycation end-products (AGEs) in streptozotocin-induced diabetic rats by Bhaskar JJ1, Shobha MS, Sambaiah K, Salimath PV. (PubMed)

(4) The life and death of beta cells by ETH Zurich

(5) Type 2 diabetes reversed by losing fat from pancreas by New Castle University

Apricots, May Be the Next Generation Chemo Alternative Anti Liver Cancer Functional Food

By Kyle J. Norton

Apricot, a functional food may be the next pharmaceutical target for the finding of an effective medicine with potential in the treatment of liver cancer, some scientists suggested.

Liver cancer is a medical and chronic condition caused by irregular cell growth in the liver tissue. 

What causes the mutation of liver cell DNA is unknown. However, according to the epidemiological studies, cancer originated from the liver are associated with livers damaged by birth defects, alcohol abuse, or chronic infection with diseases such as hepatitis B and C, hemochromatosis.

Non-alcoholic steatohepatitis (NASH), the advanced form of the non-alcoholic fatty liver disease (NAFLD). are one of the major risk factor associated with significant liver damage or the increased risk of liver cancer.

Unhealthy diet pattern and lifestyle also can contribute to the early onset of liver cancer. therefore making positive lifestyle choices such as Not smoking, eating a healthy diet and keeping physically active are some of the ways which can reduce the risk of liver cancer.

The World Cancer Reserve Fund wrote," There is strong evidence that being overweight or obese is a cause of liver cancer, consuming approximately three or more alcoholic drinks a day is a cause of liver cancer, and consuming foods contaminated by aflatoxins (toxins produced by certain fungi) is a cause of liver cancer".

Men are about 3 times more likely than women to be diagnosed with the disease 

According to the statistic, in the US., an estimated 30,610 men and 11,610 women will be diagnosed with primary liver cancer, causing the deaths of 20,540 men and 9,660 women.

The apricot tree is about 8–12 m tall and a trunk up to 40 cm diameter belonging to the family Rosaceae.

Apricot is classified in the family of the plum with yellow to orange, often tinged red on the side which is exposed to the sun.


Chemical constituents of apricot include
Oleic acid, linoleic acid, palmitic.acid, glycolipids, phospholipids, benzoic acid (I), isorhamnetin (II), quercetin (III), kaempferol-3-O-beta-D-galactopyranoside (IV), isorhamnetin-3-O-beta-D-glucopyranoside (V), isoquercitrin (VI), hypericin (VII) and rutin (VIII)(a) and flavonoid glycosides.

In the assessment of MK615, an anti-cancer substance extracted from the Japanese apricot, researchers at the Dokkyo University School of Medicine conducted an investigation to examine the anti-neoplastic effect of MK615 against hepatocellular carcinoma (HCC).

Observation of the assays from 2 HCC lines, HuH7 and Hep3B, were cultured with MK615 at concentrations of 600, 300, 150, and 0 microg/mL found that
* MK615 inhibited the growth of, and lysed, HuH7 and Hep3B cells in a dose-dependent manner

* MK615 decreased the population of cells in G2/M phase, according to the Cell cycle analysis.

* MK615 suppressed the expression of the function of Aurora A. associated with cancer cell proliferation by 34.3%, 32.9%, and 54.3% at 150, 300, and 600 microg/mL MK615, respectively.

Dr. after taking into account co and confounders said, "(These results suggested that) MK615 has an anti-cancer effect against HCC lines in vitro, and the effect is exerted through inhibition of Aurora-A activity".

Furthermore, in the evaluation of the clinical effects and feasibility of administering MK615 for patients with HCC recurred in the liver 8 mo after the surgery.in a 60-year-old female with advanced HCC, researchers found that

* Radiofrequency ablation and transarterial infusion chemotherapy were performed but the recurrence was not controlled and one year after the intrahepatic recurrence, pulmonary and lymph metastasis reappeared.

* Administration of chemo drug Sorafenib was not effective.

* MK615 was administered as a final alternative therapy after informed consent was obtained from the patient.

3 months of MK615 injection exerted a significant effect in decreasing her alpha-fetoprotein level and sizes of both the lymph node and pulmonary metastases. The patient has survived for more than 17 mo after the MK615 administration.

These results suggested that MK615 is effective against advanced liver cancer metastases.

Taken all together, apricot may be considered a functional food for the prevention and an adjunct therapy for the treatment of liver cancer.

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food apricot during the course of the disease will be necessary to complete the picture of apricot anti-liver cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources(1) A novel anti-cancer substance, MK615, from ume, a variety of Japanese apricot, inhibits growth of hepatocellular carcinoma cells by suppressing Aurora A kinase activity by Okada T1, Sawada T, Osawa T, Adachi M, Kubota K.(PubMed)
(2) Advanced hepatocellular carcinoma responds to MK615, a compound extract from the Japanese apricot "Prunus mume" by Hoshino T1, Takagi H, Naganuma A, Koitabashi E, Uehara S, Sakamoto N, Kudo T, Sato K, Kakizaki S.(PubMed)

Ginger Processes Anti Cancer Potential, Scientists Suggest

By Kyle J. Norton

Scientists may have found a pungent kitchen spice which processes the potency for the prevention and treatment of cancers, some studies found.

Cancer is the class of chronic illness characterized by cell growth disorderly and uncontrollably on some tissue and organs in the body.

Most cases of cancer start in the cells on the surface of the inner lining of specific tissue or organs in the early stage.

Most patients in this stage depending on the type of cancer do not experience any symptoms. However, at the advanced stage, as the tumor has penetrated deeply into the layers of tissue, most cancer can suppress the nearby tissue and nerve cells, causing localized symptoms and severe pain.

At this stage, the cancerous cells can travel a distance away from the original site to infect other healthy tissue and organs.

The exact causes of cancer are unknown. Epidemiological studies, depending on the type of cancer suggested that aging, sun exposure, radiation exposure, toxic chemicals viruses and bacteria, certain hormones, family history of cancer are some most common prevalent risk factors of cancer.

Some researchers suggested. obesity or overweight, poor diet, and lifestyle are the most common preventable risk factors associated with cancer onset in the US.

According to the statistic, approximately:over 200,000 new cancer diagnoses and 80,800 deaths from cancer in Canada in 2017.

Lung, colorectal, breast, and prostate cancer are accounted for about half of all cancer diagnoses and deaths. 

About 1 in 2 Canadians will develop cancer in their lifetimes and 1 in 4 will die of the disease.

In the concern of the prevalence of overweight and obesity is increasing worldwide and a link between obesity and cancer is growing, Dr. Karen Basen-Engquis, the lead author launched an investigation to examine the obesity and cancer risk.

At the final report of the experiment, the team said, " Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%." and "Additionally, studies of patients who have had bariatric surgery for weight loss report reductions in cancer incidence and mortality, particularly for women".

And, "Numerous cohort studies, summarized in systematic reviews, have shown a link between obesity and cancer incidence overall and for selected cancer sites (eg, endometrial, postmenopausal breast, colon, and esophageal adenocarcinoma)".

These results clearly suggested the risk of cancer is elevated in obese and overweight population compared to healthy weight individuals.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

On finding a natural whole food for the treatment of cancer with no side effects, researchers looked into the ginger antiemetic and anticancer activities.

By examing the phytochemistry, bioactivity, and molecular targets of ginger constituents, especially 6-shogaol, researchers suggested that the content of 6-shogaol found very low in fresh ginger, but significantly higher after steaming exerts a significant anti-cancer activity.
Dr. Wang CZ, after taking into account co and confounders, said, "6-shogaol can be served as a lead compound for new drug discovery" and " The lead compound derivative synthesis, bioactivity evaluation, and computational docking provide a promising opportunity to identify novel anticancer compounds originating from the ginger".

Furthermore, in the examination of the plant-derived exosome-like nanoparticles, a promising substitution and exhibit anti-cancer biocompatibility through oral, intranasal administration, researchers looked into ligands from the ginger.

Application of ligands from the ginger demonstrated an anticancer effect by the ability to exhibit the gene expression in T-cells with siRNAs through activating innate immune responses.

These results suggested that ligands on ginger derived exosome-like nanovesicles (GDENs) inhibit tumor growth on a xenograft model by intravenous administration.

Taken together, ginger processed ligands on ginger derived exosome-like nanovesicles (GDENs)and 6-shogaol may be considered a function for the prevention and combined with primary therapy for the treatment of cancer without inducing adverse effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Cancer Chemoprevention Effects of Ginger and its Active Constituents: Potential for New Drug Discovery by Wang CZ1, Qi LW1,2, Yuan CS. (PubMed)
(2) Optimization protocol for the extraction of 6-gingerol and 6-shogaol from Zingiber officinale var. rubrum Theilade and improving antioxidant and anticancer activity using response surface methodology by Ghasemzadeh A1, Jaafar HZ2, Rahmat A. (PubMed)
(3) Arrowtail RNA for Ligand Display on Ginger Exosome-like Nanovesicles to Systemic Deliver siRNA for Cancer Suppression by Li Z1, Wang H1, Yin H1, Bennett C2, Zhang HG3, Guo P. (PubMed)
(4) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist and Maria Chang. (PMC)

Manaku Honey, the Potential Cartilage Repair Functional Food

By Kyle J. Norton

Scientists may have found a golden liquid for the treatment of cartilage damage without inducing any side effects, some studies suggested.

Cartilage is an important structural component placed in the joints of bone with a function to prevent the end of the bone collided from one to another.

Cartilage is a firm tissue but is softer and much more flexible than bone.

Due to the lack of blood vessels connected to the cartilage to supply the chondrocytes with nutrients, repairing the damage of cartilage are more slowly than other tissues.

Cartilage repair is an act is to restore the surface of an joint cartilage. However, how sufficiency of the works is totally depending on the degree of the damage.

In conventional medicine, cartilage damage due to a single injury, or lesion can be repaired successfully. However, with many lesions in one joint, are less likely to benefit from the surgery. cartilage, particularly in older population.

In the article "Articular Cartilage Restoration", the American Academy of Orthopaedic Surgeons wrote, "Many procedures to restore articular cartilage are done arthroscopically" and "Some procedures require the surgeon to have more direct access to the affected area. Longer, open incisions are required. Sometimes it is necessary to address other problems in the joint, such as meniscal or ligament tears when cartilage surgery is done"

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

With an aim to find the natural ingredient or whole food for the cartilage repair in replacement of that conventional medicine with no side effects, researchers at a number of institutes conducted a joint study to evaluate the nature-derived hydrogels, a promising class of scaffolds for cartilage tissue engineering, mimicking the native cellular microenvironment.

Manuka honey made hydrogels able to inhibit the proliferation of S. aureus and S. epidermidis clinical isolates and no cytotoxic effects were detected on human mesenchymal stem cells seeded on the hydrogels.

Manuka honey initiated a consistent expression of collagen II and high synthesis of
Sulfated glycosaminoglycans (GAGs) and proteoglycans, thus indicating the formation of the cartilage matrix.

Where Sulfated glycosaminoglycans and proteoglycans are considered promising artificial extracellular matrix components to improve the regeneration of tissues, such as cartilage repair.

These results suggested Manuka honey processes a similar action as those of synthetic substances used for the treatment to improve cartilage regeneration.

In order to understand the effect of Manuka honey in cartilage repair, researcher launched a differentiation of the research paper "Antibacterial effectiveness meets improved mechanical properties: Manuka Honey/Gellan Gum composite hydrogels for cartilage repair", Bonifacio et al.

And suggested that before Manuka honey can be used for the treatment of cartilage repair, there are some criteria must be met. you can view them at the sources

Due to the limitation of the study, therefore, further data collection large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of Manuka honey cartilage repair possibilities.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

(1) Antibacterial effectiveness meets improved mechanical properties: Manuka honey/gellan gum composite hydrogels for cartilage repair by Bonifacio MA1, Cometa S2, Cochis A3, Gentile P4, Ferreira AM5, Azzimonti B6, Procino G7, Ceci E8, Rimondini L9, De Giglio E10. (PubMed)
(2) Data on Manuka Honey/Gellan Gum composite hydrogels for cartilage repair by Bonifacio MA1, Cometa S2, Cochis A3, Gentile P4, Ferreira AM4, Azzimonti B3,5, Procino G6, Ceci E7, Rimondini L3,5, De Giglio E1. (PubMed)

Herbal Arnica, the Natural Muscle Pain Reliever

By Kyle J. Norton

Herbal Arnica may be used as a natural painkiller in alleviating pain with inducing any side effects, some scientists suggested.

Pain a natural response from the brain caused by intense or damaging stimuli with an aim to protect our body against injury or damage.

Pain can vary greatly such as mild, sharp, severe, and dull. Acute pain is the sensation that lasts for a short period of time.

Chronic pain is pain that lasts longer than 12 weeks. Most cases of chronic pain arise from an initial injury such as back injury or diseases such as rheumatoid arthritis, osteoarthritis, and fibromyalgia.

There are different types of pain, including

* Nociceptive pain is a normal response to injury of tissues such as skin, muscles, visceral organs, joints, tendons, or bones.

* Neuropathic pain is a type of pain caused by a primary lesion in the somatosensory nervous system

and 

* Inflammatory pain is associated with the production of proinflammatory cytokines in response to the acute phase of infection and chronic inflammatory diseases.

Conventional medicine used for the treatment of pain are effective in improving the quality of life of patients. However, long-term use has been known to induce some common fatigue, mental cloudiness, unclear thinking, and mood change and serious cardiovascular issues, sexual dysfunction, side effects

Most common prescription painkillers are the nonsteroidal anti-inflammatory drug (NSAID) and
Opioids

Therefore, if you currently taking medication to reduce chronic pain, please make sure you know all the side effects

Arnica is a herbaceous species, genus perennial, belonging to the family Asteraceae, native to Europe and Asia.

The plant has been used in herbal medicine for centuries to treat strains, sprains, and bruises.
Colon Cancer is defined as a condition of the abnormal proliferation of cells in the colon.
Pain is a feeling triggered in the nervous system as a result of often caused by intense or damaging stimuli.

Besides containing contain helenalin as it main ingredient used as an anti-inflammatory agent in herbal medicine, the herbal plant also contains 11,13- dihydrohelenaline, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin.

In the finding, the natural topical compound for the treatment revelation of pain and a replacement of conventional a painkiller with little or no side effects, researchers at the Department of Plastic Surgery of Queen Victoria Hospital in West Sussex, examine the herb Arnica montana, in topical formulations used in the traditional medicine for pain relief.

Thirty-seven patients undergoing bilateral endoscopic carpal-tunnel release between June 1998 and January 2000 were included in a double-blind, randomized comparison of Arnica administration versus placebo.

Grip strength, wrist circumference, and perceived pain measured 1 and 2 weeks after surgery. Application of Arnica showed no difference in grip strength or wrist circumference but a significant reduction in pain experienced after 2 weeks compared to placebo.

Dr. Pumpa KL, the lead author at the University of Canberra in the study to reaffirm the use of topical Arnica gel, for the treatment of pain, evaluated the Arnica effect on the inflammation and muscle damage, and in turn, improve performance in well-trained males experiencing delayed onset muscle soreness (DOMS).

The study included twenty well-trained males matched by maximal oxygen uptake (V̇O2 Max) completed a double-blind randomized placebo-controlled trial.

Topical Arnica was applied to the skin superficial to the quadriceps and gastrocnemius muscles immediately after a downhill running protocol designed to induce DOMS. 

Topical Arnica group exerted significantly less pain through muscle tenderness and VAS 72 hours post-exercise and did not affect any performance assessments or markers of muscle damage or inflammation.

Furthermore, topical Arnica used immediately after intense eccentric exercise and for the following 96 hours did not have an effect on performance or blood markers.

The doctoral team after taking into account co and confounders said, " (Topical Arnica applications) demonstrate the possibility of providing pain relief three days post-eccentric exercise".

Taken altogether, topical Arnica gel may be considered a functional herb for the prevention and treatment of muscle pain and damage due to over muscle exercises.

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Use of Arnica to relieve pain after carpal-tunnel release surgery by Jeffrey SL, Belcher HJ. (PubMed)
(2) The effects of topical Arnica on performance, pain, and muscle damage after intense eccentric exercise by Pumpa KL, Fallon KE, Bensoussan A, Papalia S.(PubMed)