Curcumin, the Kitchen Spice Which is Also A Potent Anti Non-alcoholic Fatty Liver Disease (NAFLD) Remedy, Scientists Say

By Kyle J Norton, Master of Nutrition

Scientists may have discovered a potent natural ingredient for the prevention and treatment of Nonalcoholic Fatty liver disease (NAFLD) without inducing any side effects, some studies suggested.

Non-alcoholic fatty liver disease is a condition of liver disorder caused by the accumulation of fat, other than abusive alcohol consumption.

Although the condition may not be dangerous in the early stage. However, as the condition progresses, NAFLD will develop nonalcoholic steatohepatitis (NASH). At the advanced stage, nonalcoholic fatty liver disease (NAFLD) can develop into cirrhosis, the major risk factor of liver cancer scarring and dysfunction of the liver.

Although researchers do not know the exact cause of nonalcoholic fatty liver disease (NAFLD), they do know that certain risk factors are associated with the early onset of the disease, including obesity, starvation and protein malnutrition, long-term use of total parenteral nutrition, intestinal bypass surgery for obesity, rapid weight loss.

Certain medical conditions such as hyperlipidemia (elevated lipids in the blood), insulin resistance and high blood pressure. genetic preposition and long-term use of medication are also the prevalent risk factors of the disease onset.

Sadly, according to the statistic provided by the liver foundation, more than 50% of Canadians are overweight. 75% of obese individuals are at risk of developing a fatty liver and  23% of obese individuals are at risk of developing fatty liver with inflammation.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.. Curcumin is one of the natural phenols in the plant.

In the findings of natural ingredients from herbal medicine for the treatment of liver diseases with no side effects, researchers at the GENyO Center Pfizer-University of Granada & Andalusian Government Centre for Genomics & Oncology launched an investigation to examine the effect of curcumin for the management of liver-related diseases.

In combating liver diseases, curcumin showed a significant activity in exerting the hypolipidic effect, which prevents the fatty acid accumulation in the hepatocytes, causing metabolic imbalances, the major cause of nonalcoholic steatohepatitis.

In the protective activity, curcumin, not only demonstrates an effect in the context of chronic liver diseases but also inhibits the carcinogenesis and age-related processes, through is its potent antioxidant activity. 

Furthermore, curcumin also acts on NF-κβ in the prevention of liver cell death and cell alteration.

NF-κβ is a protein which controls transcription of DNA, cytokine production and cell survival.

These result suggested that curcumin is a liver protective micronutrient, closely related to cellular redox balance.

Further evaluation of the curcumin derivative on non-alcoholic steatohepatitis (NASH) rats, researchers at The Second Affiliated Hospital of Chongqing Medical University conducted a study on rat induced by high-fat diet combined with carbon tetrachloride.

All mice are randomly divided into 5 group. After injection with carbon tetrachloride, these rats were then treated with curcumin and curcumin derivative, with the saline treating group as control.

Rats treated with curcumin derivatives showed a remarkable reduction in serum ALT (U/L), AST (U/L) and TC (mmol/L), compared to the saline group,

Curcumin derivative group also exerts a decrease of fibrosis, liver index and serum ALT, AST.

The liver steatosis and inflammation grade were also significantly improved

Dr.Zeng CH, the lead author at the final report said, " the water-soluble curcumin derivative displays superior bioavailability to the parent curcumin, which can effectively improve the lipid metabolism and delay the progression of hepatic fibrosis in rats with steatohepatitis".

Taken altogether, curcumin, a kitchen spice may be considered a functional food and an adjunct therapy for the prevention and treatment of non-alcoholic fatty liver disease without inducing any side effects.

However, additional data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of Curcumin anti-on-alcoholic fatty liver disease possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Curcumin and liver disease.Vera-Ramirez L, Pérez-Lopez P, Varela-Lopez A, Ramirez-Tortosa M, Battino M, Quiles JL.(PubMed)
(2) [The effects of curcumin derivative on experimental steatohepatitis].[Article in Chinese] by Zeng CH, Zeng P, Deng YH, Shen N, Peng ML, Liu Q, Ren H.(PubMed)

Chickweed Methanolic Extract, the Potent Anti Obesity Supplements, Scientists Say

By Kyle J. Norton, Master of Nutrition

Adding one or two portions of chickweed into the daily diet may have a positive and profound effect in inducing weight loss, particularly, in overweight and obese patients, some studies suggested.

Obesity is a medical condition of extreme overweight. The disease is an epidemic in the United States. According to the statistic, over 68% of the US population are overweight and half of these overweight people are obese.

According to epidemiological studies, patients with obesity are at a higher risk for serious diseases, such as type 2 diabetes, heart disease, and cancer.

According to Body Mass Index (BMI), the range of overweight is between 25 and 29.9. If your BMI is 30 or over you are considered obese.

The exact causes of obesity are unknown, however, there are numbers of prevalent risk factors that cause the early onset of the condition including consuming too many calories than the body needs, a sedentary lifestyle, not sleep enough, too much stress that lead to endocrine disruption and medication that cause patients to put on weight..

Genetic mutation inherited from the parents also is one of the major cause of obesity.

Dr. Hélène Choquet, the lead author in the study "Genetics of Obesity: What have we Learned?" In 2001, six genes were linked to monogenic human obesity and no common variants were reproducibly associated with polygenic obesity. By 2008, progress in the field led to the discovery of eight monogenic genes and four polygenic genes (FTO, PCSK1, MC4R, CTNNBL1) from associated studies at the genome-wide level of significance".

In the management of overweight and obese patients, researchers at the Park Nicollet Bariatric Surgery Center suggested, "lifestyle modifications should be recommended for every patient dealing with overweight or obesity" and " No single diet has proven to be superior to others overall in terms of weight loss outcomes. However, a low-carbohydrate (ie, ketogenic) diet has been shown to reduce insulin resistance in patients with diabetes and may be considered for this subgroup of patients".

" Exercise alone has not been shown to produce substantial weight loss, but it is helpful during the weight loss phase to preserve lean muscle mass, and it has a role in weight maintenance. Though sleep deprivation has been implicated in weight gain, the effect of improving sleep quality/duration on reducing excess weight has yet to be studied adequately".

These results indicated, actively engaging in low calory diet without causing nutrient deficiency and physical exercise on a long-term basis, and reducing stress levels may be considered a good management for overweight and obese patients to lose weight.

Chickweed is a cool-season annual plant in the genus S. media, belonging to the family Caryophyllaceae, native to Europe.

The herb has been used in herbal medicine as astringent, carminative, demulcent, diuretic, expectorant, laxative, refrigerant, vulnerary agent and to treat skin conditions, indigestion, eczema, cough, rashes,...

In the finding of a natural ingredient without a side effect in replacement of conventional medicine and surgery in obese patients researchers at the CMR College of Pharmacy, Medchal conducted an evaluation of the effect of chickweed (S. media (MESM)) on food consumption pattern, change in body weight, thermogenesis, lipid metabolism, and histology of fat pad, using progesterone-induced obesity model in female albino mice.

Methanolic and alcoholic extracts of the S. media were used in the experiment. At the final assessment, researchers suggested, application of a methanolic extract of S. media (MESM) demonstrates a significant effect in preventing the increase in body weight, adipose tissue weight and size, and upturned obesity and associated complications, compared to the alcoholic extract.

Further analysis also discovered, the antiobesity activity produced by MESM is attributed to the anorexic property mediated by saponin and flavonoid and partly of by its β-sitosterol content.

Moreover, β-sitosterol, a plant sterol having structural similarity with dietary fat isolated from the methanolic extract of S. media shows a physical competition in the gastrointestinal tract against fat absorption.

Other chemical compounds found in the methanolic extract such as saponin, flavonoids, steroids and triterpenoids, glycosides, and anthocyanidins are also found in aiding the results of weight reduction.

Additionally, the examining of numerous trials conducted by some institutes with an aim to find and develop new anti-obesity drugs through herbal sources with minimizing side effects compared to anti-obesity drugs, researchers at the University of Science and Technology launched an evaluation of the quality control parameters, quantitative phytochemical analysis (total phenolic, total flavonoids and total saponin content), and the anti-obesity effect of lyophilized juice (LJ) of Stellaria media (Linn.) Vill. in vitro and in vivo models.

The anti-obesity effect of LJ was assessed at two doses, 400 mg/kg and 900 mg/kg body weight in mice fed a high-fat diet with or without LJ for 6 weeks.

Application of both doses in tested mice inhibited pancreatic amylase and lipase activity and elevated plasma triacylglycerol level.

 At the dose of 900 mg/kg body weight of the mice fed with a high-fat diet,  LJ suppressed the increase in body weight, retroperitoneal adipose tissue, liver weights and serum parameters viz., total cholesterol, total triglyceride, LDL-cholesterol level

Dr. Rani N, the lead author at the final report, wrote, "The anti-obesity effects of LJ in high-fat-diet-fed mice may be partly mediated through delaying the intestinal absorption of dietary fat and carbohydrate by inhibiting digestive enzymes". 

The findings suggested that chickweed methanolic extract may be considered an adjunct therapy in preventing weight gain in overweight and obese subjects.

Intake of methanolic extract of chickweed (S. media (MESM)) should be taken with extreme care, as acute liver toxicity has been reported in numbers of case

However, further data collection on large example size and multi-centers studies performed with human consumption of chickweed during the course of the disease will be necessary to complete the picture of the wholefood anti-obesity possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1)Antiobesity effect of Stellaria media against drug induced obesity in Swiss albino mice by Chidrawar VR1, Patel KN, Sheth NR, Shiromwar SS, Trivedi P.(PubMed)
(2) Quality assessment and anti-obesity activity of Stellaria media (Linn.) Vill by Rani N1, Vasudeva N, Sharma SK. (PubMed)
(3) Genetics of Obesity: What have we Learned? by Hélène Choquet1 and David Meyre. (PMC)
(4) Obesity: dietary and lifestyle management by Vesely JM1, DeMattia LG. (PubMed)

Herbal Chamomile May Be the Next Generation of Whole Food Medicine for Treatment of Chronic Inflammatory Diseases

By Kyle J. Norton, Master of Nutrition

Herbal Chamomile may be the next generation of whole food medicine of blocking the onset of acute and chronic inflammatory diseases, some studies suggested.

Inflammation is a natural and systematic immune response to the body damage and injure. Upon received the information from the central nervous system, macrophages, the largest cells in the immune system stimulate the production of pro-inflammatory cytokines to the site of infection to protect against possible exposure to infectious agents.

The aim of these actions is to minimize the damage and speed up the healing processes. However, if the pro-inflammatory cytokines are overexpressed,  they can cause damage to the nearby healthy and formation of the scars to the infected tissue.

Chronic inflammation is the condition when the immune system can not kill all infectious pathogens in the acute phase, leading to persistent low-grade inflammation, judged by a small rise in immune system markers found in blood or tissue.

The longterm low-grade inflammation has been found to trigger autoimmunity in which the immune system mistakenly attacks the body tissue in the damage site and other healthy tissue.

Most people with chronic inflammation are experiencing symptoms of body pain, persistent fatigue, and insomnia, psychological issues of depression, anxiety and mood disorders and long-term gastrointestinal discomfort, such as constipation, diarrhea, and acid reflux. 

If you have some of the symptoms above, please check with your doctor. A blood test of inflammatory markers is necessary to rule out the possibility.

Chamomile is also known as camomile,  a common name of many species daisy-like plants in the family Asteraceae.

The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.

Chemical ingredients
Guaianolides matricarin and achillin, acetoxyachillin and leucodin (= desacetoxymatricarin), corresponding C-11 stereoisomers(a),(Z)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (cis-GMCA), chlorogenic acid, (E)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (trans-GMCA), quercetagetin-7-O-β-d-glucopyranoside, luteolin-7-O-β-d-glucoside, apigenin-7-O-β-d-glucoside, chamaemeloside, apigenin 7-O-(6″-O-acetyl-β-d-glucopyranoside), apigenin] and one polyacetylene (tonghaosu)(b).

In the study to reaffirm the inflammatory effect of chamomile used in traditional medicine for the treatment of inflammation-related disorders, researchers at the Case Western Reserve University conducted an examination of the herbal inhibitory effects on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression, and its potential anti-inflammatory mechanisms using RAW 264.7 macrophages.

In LPS-induced NO production, application of chamomile significantly blocked the series of the proinflammatory cytokine with the function to protect the cell against infection of LPS, namely, the IL-1β, IL-6, and TNFα in RAW 264.7 macrophages.

Furthermore, chamomile caused a reduction in LPS-induced iNOS mRNA and protein expression, a family of primary inflammatory response gene.

In RAW 264.7 macrophages, LPS-induced DNA binding activity of RelA/p65 in the prevention of production of anti-inflammatory cytokines was significantly inhibited by chamomile.

Moreover, chamomile treatment also inhibited the release of LPS-induced prostaglandin E(2), a bioactive lipid that can elicit a wide range of biological effects associated with inflammation, in RAW 264.7 macrophages.

Interestingly, the anti-inflammatory effect of Chamomile was attributed to the inhibition of COX-2, the proinflammatory enzyme activity by blocking the reduction in LPS-induced COX-2 mRNA and protein expression, without affecting COX-1 expression in the inflammatory response in comparison to the non-steroidal anti-inflammatory drug, sulindac.

These results suggested that chamomile processed a mechanism of action similar to those of non-steroidal anti-inflammatory drugs may be considered a functional food for the prevention and treatment of chronic inflammation.

However, due to limitation of the above study, additional data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of chamomile anti-inflammatory diseases possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Chamomile: an anti-inflammatory agent inhibits inducible nitric oxide synthase expression by blocking RelA/p65 activity by Bhaskaran N1, Shukla S, Srivastava JK, Gupta S.(PubMed)
(2) Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity by Srivastava JK1, Pandey M, Gupta S.(PubMed)

Carrot, the Functional Food Which Normalizes the Levels of Cholesterol, Researchers Suggest

By Kyle J. Norton, Master of Nutrition

Carrot may have found a therapeutic and positive effect in inhibiting the abnormally high blood cholesterol some scientists suggested.

Hyperlipidemia is a condition characterized by abnormally high blood cholesterol in the blood.

The exact causes of the condition are unknown. However, most researchers suggested that genetic mutation inherited from the parents, unhealthy diet and lifestyle and some medical conditions such as diabetes, kidney disease, and hypothyroidism, are the most common risk factors that cause the early onset of the syndrome.

Truly, mutation of LDLRAP1 gene is inherited in an autosomal recessive pattern which contributes to the risk of hyperlipidemia. However, parents of the patient who carry only one copy of the altered gene, are not at risk of high blood cholesterol levels.

Dr. GS Mannu,, the lead author in the study "Evidence of Lifestyle Modification in the Management of Hypercholesterolemia" said, "Target cholesterol levels set out in various guidelines could be achieved by lifestyle changes, including diet, weight reduction, and increased physical activity with the goal of reducing total cholesterol to <200 mg/dL and LDL-C <100mg/dL. Various dietary constituents such as green tea, plant sterols, soy protein have important influences on total cholesterol. Medical intervention should be reserved for those patients who have not reached this goal after 3 months of non-pharmacological approach".

This statement indicated people who follow the Western diet with high amounts of saturated fat and trans fat, red meat, processed food and less in the nut, fruits, and vegetable are at higher risk of abnormally high blood cholesterol.

In other words, patients with hyperlipidemia may lower their blood cholesterol with the change of diet pattern and active lifestyle.

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asian and Europe.

In the reaffirm of the effect of a diet rich in fruit and vegetable can protect against cardiovascular diseases by acting on cholesterol metabolism and on oxidative stress, researchers launched an investigation to examine whether daily carrot consumption (provided as lyophilized powder) could differentially influence the consequences of cholesterol supplementation on lipid metabolism and oxidative stress in C57BL/6J mice.

14 mice were randomized in four groups. Mice were fed either control diets (without or with 0.25% cholesterol added) or lyophilized carrot enriched diets (20% wt/wt without or with 0.25 % cholesterol added) for 4 weeks. 

At the end of the study, researchers found.

* Carrot included in the diet mice group shows a decrease of cholesterol by 41% and triglycerides by 49 % in plasma and in the liver by41% and -39%, respectively in animals fed cholesterol-supplemented diets.

* Carrot fed mice group also induced an increase of total neutral sterols fecal excretion, which inhibits digestive cholesterol absorption.

* Carrot diet increased antioxidant status in cholesterol-fed mice as related by the 16% higher FRAP values.

* Although vitamin E was not affected by carrot diet, vitamin E/TG ratio was significantly higher in animals fed carrot diets. By comparing to the healthy mice, the dyslipidaemic mice had higher serum vitamin E (p<0.001), but serum vitamin E / total cholesterol ratio did not differ between the dyslipidaemic mice and healthy controls (p>0.05)

Further differentiation also suggested that The carrot diet protect the heart tissue through the expression of an increase of vitamin E in the heart in both cholesterol-free and cholesterol-supplemented mice. 

Dr. Nicolle C, the lead author after taking into account co and confounders said, "carrot ingestion decreases lipemia and improves antioxidant status in mice".

These results indicated a protective impact against CVD linked to atherosclerosis by regular intake carrot diet and these effects was attributed to the synergistic effect of fiber and associated antioxidants.

Additionally, in the examination of the vegetables major dietary sources of fibers and antioxidants such as carotenoids, polyphenols and vitamin C in the contribution to the protective effects against cardiovascular diseases, researchers conducted a study in the rat model to test the effects of a 3-week supplementation of the diet with carrot (15% dry matter) on lipid metabolism and antioxidant status.

At the final report of the experiment, researchers showed
* Carrot intake significant decrease cholesterol level in the liver by 44% and level of liver triglycerides by 40%.

* Carrot diet increases the fecal total steroids excretion increased by 30% in the carrot diet compared to the control, an indication of reduced cholesterol absorption.

* The secretion of bile acids was maintained, whereas the cholesterol apparent absorption was reduced in rats fed with carrot diet.

* Carrot consumption also improves the antioxidant status

* The carrot diet provided carotenoid antioxidants: 5.1 mg beta-carotene, 1.6 mg alpha-carotene and 0.25mg lutein per 100 g diet.

Dr. Nicolle C the lead author in the summary once again said, " Carrot consumption modifies cholesterol absorption and bile acids excretion and increases antioxidant status and these effects could be interesting for cardiovascular protection".

Taken altogether, there is no doubt that carrot with abundant antioxidants may be considered a functional food and an adjunct therapy for the prevention and treatment of patients with hyperlipidemia.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Lyophilized carrot ingestion lowers lipemia and beneficially affects cholesterol metabolism in cholesterol-fed C57BL/6J mice by Nicolle C1, Gueux E, Lab C, Jaffrelo L, Rock E, Mazur A, Amouroux P, Rémésy C.(PubMed)
(2) Effect of carrot intake on cholesterol metabolism and on antioxidant status in the cholesterol-fed rat by Nicolle C1, Cardinault N, Aprikian O, Busserolles J, Grolier P, Rock E, Demigné C, Mazur A, Scalbert A, Amouroux P, Rémésy C.(PubMed)

Green Tea and Its polyphenol (-)-epigallocatechin-3-gallate EGCG Kill Over 84% of Endometrial Cancer Cells, Scientists Reveal

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)

Scientists may have found a popular beverage that processes a significant effect in reducing risk and treatment of endometrial cancer, according to some studies.


Endometrial cancer is a medical condition characterized by cell growth uncontrollably in the endometrium.

At the late stage, the cancerous cell may travel a distance away from the original site to infect other organs and tissues.

Some researchers suggested that endometrial cancer is not caused by a single factor but a number of conditions.

Women who have a persistent irregular ovulation pattern due to conditions of polycystic ovary syndrome, obesity, and diabetes are associated with the higher risk of the disease.

The risk of endometrial cancer is also increased in women who are taking hormone therapy after menopause, containing estrogen.

Most common symptoms are persistently abnormal vaginal bleeding. If you are experiencing some of the above symptoms, you should see your doctor right the way to rule out the possibility.

The early stage of endometrial cancer is treated successfully by surgery, including removing the uterus.

According to a statistic provided by the American Cancer Society, the 5-year survival rate for women with stage 0 endometrial cancer is 90% and stage IA endometrial cancer is 88%.

Green tea, a precious drink processed numbers of health benefit is known to almost everyone in Asia and the Western world.


In the experiment of green tea bioactive compound against the progression of tumor xenografts of human endometrial cancer, researchers found that (-)-epigallocatechin-3-gallate EGCG demonstrates a significant effect in reduced risk of endometrial cancer development through the bioactive chemicals anti-tumor angiogenesis properties.

In fact, the anti-cancer active compound efficacy was attributed to the modulation of expression of vascular endothelial growth factor A (VEGFA) protein in the established new vessel to stimulate the onset of cancer and cancer cell proliferation and HIF-1 functions in the activated transcription of many genes, that regulate cellular and systemic homeostatic response to external changes to tumor growth.

Furthermore, application of EGCG also suppressed responses of chemokine (C-X-C motif) ligand 12 (CXCL12) in expression of multiple physiological processes,  promoted invasion and metastasis of tumor cells in connected tissues of the uterine mucosa (endometrium), thus reducing the infiltration of VEGFA-expressing tumor-associated macrophages (TAMs) in supplying rapidly growing malignant tissues with essential nutrients and oxygen.

Additionally, further analysis also insisted that EGCG restricted secretion of vascular endothelial growth factor A (VEGFA) in initiated endometrial cancer growth by inhibiting the function of PI3K/AKT/mTOR/HIF1α pathway in the regulation of many cellular processes, including cell survival, proliferation, and growth.

After taking account all findings, treatment with EGCG reduced risk of endometrial cancer onset may be results of EGCG suppressed secretion in both fronts,  the decreased cancer cell-secreted VEGFA and inhibited TAM-secreted VEGFA in endometrial cancer progression.

Further differentiation, also showed that green tea polyphenol (-)-epigallocatechin-3-gallate reduced cancer expansion by suppressing the expression of proliferation markers which act indirectly to stimulate endometrial epithelial proliferation in estrogen receptor α, progesterone receptor, proliferating cell nuclear antigen and cyclin D1.

The overexpression of cyclin D1 has linked to the development and progression of cancer.

The proliferating cell nuclear antigen is a protein with the function of cell cycle regulation and/or DNA replication and DNA synthesis and DNA repair.

Importantly, the inhibition of EGCG also decreased the activation of ERK, the extracellular signal-regulated kinases protein in cancer cell division and down expression of transcription factors fos and jun, the cellular immediate-early genes in the induced transient cancer cell division and differentiation processes.

The function of EGCG in reduced risk of endometrial cancer also expressed through Bcl-2-associated X protein, cleavage of caspase-3 and poly(ADP-ribose) polymerase actions in the induction of cancer cell apoptosis and suppression of antiapoptotic protein Bcl-2 (B-cell lymphoma 2).


Bcl-2-associated X is a protein with the function of anti- or pro-apoptotic regulators involved in a wide variety of cellular activities.

B-cell lymphoma 2, a family protein with function in the regulation of cell apoptosis.

Cleavage of caspase-3 also is known as a critical executioner of apoptosis,

Poly(ADP-ribose) polymerase is a protein with function involved in a number of cellular processes, including programmed cell death.

Implicitly, application of EGCG also increased production of free radical expression in the initiated cytotoxic effect by reducing levels of antioxidant glutathione levels and activating the p38 in the induction of  cancer cells death without inducing toxicity to normal cells

P38 mitogen-activated protein kinases (MAPKs) are activated by a wide range of cellular stresses in the response to inflammatory cytokines involved in cell differentiation, apoptosis, and autophagy.

Indeed, according to a systematic review of literature published on database of PubMed, Embase, Cochrane Library and China Biological Medicine Database up to February 2, 2015, researchers indicated that green tea consumption is associated with a reduced risk of EC (relative risk of .78) and each additional cup of green tea consumed per day decreased risk of developing EC by 11%.

Particularly, the intake of green tea associated with the attenuated risk of endometrial cancer was 84.33% compared to 5.07 % of black tea.

Taken together, green tea and its polyphenol (-)-epigallocatechin-3-gallate EGCG may be considered a functional food used conjunction with standard therapy in reducing risk and treatment of endometrial cancer.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea, black tea consumption, and risk of endometrial cancer: a systematic review and meta-analysis by Zhou Q1, Li H2, Zhou JG3, Ma Y4, Wu T5, Ma H6.(PubMed)
(2) A prodrug of green tea polyphenol (-)-epigallocatechin-3-gallate (Pro-EGCG) serves as a novel angiogenesis inhibitor in endometrial cancer by Wang J1, Man GCW2, Chan TH3, Kwong J1, Wang CC4. (PubMed)
(3) (-)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation by Manohar M1, Fatima I, Saxena R, Chandra V, Sankhwar PL, Dwivedi A.(PubMed)

How to Protect Your Skin Against Lipid Peroxidation Naturally

By Kyle J. Norton, Master of Nutrition

Scientists may have found a herbal medicine for the protection of skin against the oxidative stress in the induction of skin diseases, with no side effects, some studies suggested.

What are the exact causes of skin damage? Some researchers suggested that long-term exposure to the sun is the most common cause of skin damage. UV rays can damage the DNA of skin cells, affecting the normal skin cell growth. UV rays have been linked to the early onset of skin cancer, epidemiologically.

Other causes of skin damage include chronic stress, skin diseases such as pimples, acne, or rosacea.

Truly, improper skin care and healing of a pimple, acne, and rosacea can damage the facial skin, leaving uneven skin tone.

Dr. Ying Chen, the lead scientist in the study "Brain-Skin Connection: Stress, Inflammation and Skin Aging" wrote, "The intricate relationship between stress and skin conditions has been documented since ancient times. Recent clinical observations also link psychological stress to the onset or aggravation of multiple skin diseases".

Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.

The herb has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.

Ingredients
Besides having major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.

In the study to reaffirm the sun protective effects of essential oil extracted from Calendula flowers (Calendula officinalis L., Asteraceae).\in a cream formulation, researchers at the Bhagwant University launched an investigation using in vitro method employing UV-visible spectrophotometer (Shimazdu-1600).

Application of the cream exerted a significant effect in protecting the skin against UV radiations in form of sunscreen cream and maintaining the natural pigmentation of the skin, without inducing no side effects.

Furthermore, application of a cream (O/W) containing 4% and 5% of Calendula essential oil on biochemical parameters of the skin of albino rats against UV-B radiation also decreased the oxidative stress markers observed by a significant decrease in the malondialdehyde level.

Additional analysis suggested that 4% and 5% of Calendula essential oil inhibited the levels of oxidative stress and lipid peroxidation through stimulating the production of antioxidant enzymes such as catalase, glutathione, superoxide dismutase in the host and increasing the levels of ascorbic acid, and the total protein level after 1 month of daily irradiation and treatment, compared to untreated control groups.

Interestingly, the cutaneous application of the essential oil of Calendula prevents UV-B-induced alterations in the level of antioxidants in skin tissue.

These discoveries indicated reactive oxygen species (ROS) generated from UV-B radiation with the capacity to cause oxidative decomposition which leads to the formation of toxic components and lipid peroxidation are totally inhibited by the topical 4% and 5% of Calendula essential oil.

The Islamia University of Bahawalpur, launched an evaluation to test the effects of newly formulated topical cream of Calendula extract on the mechanical parameters, such as age-related changes in skin, skin elasticity, skin fatigue, skin hydration, and antiaging, using the Cutometer 580 MPA device designed to measure the mechanical properties of the skin in response to the application of negative pressure.

Two creams (base and formulation) prepared in the study were applied to the cheeks of 21 healthy human volunteers for a period of eight weeks. Every individual was asked to come on week 1, 2, 3, 4, 5, 6, 7, and 8 for measurements, using Cutometer MPA 580 every week.

At the end of the experiment, researchers found that newly formulated topical cream of Calendula extract exerts significant improvements only in hydration and firmness of skin.

The findings suggested that Calendula essential oil and extract may have a potential effect in preventing skin damage by UV-B radiation and protecting the skin against damage due to oxidative stress.

However, due to the limitation of the above studies, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the exposure will be necessary to complete the picture of skin protective possibilities.


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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Phytochemical Constituents and PharmacologicalActivities of Calendula officinalis Linn (Asteraceae): a review by BP Muley, SS Khadabadi and NB Banarase (Tropical Journal of Pharmaceutical Research)
(2) Assessment of In vitro Sun Protection Factor of Calendula Officinalis L. (Asteraceae) Essential Oil Formulation by Mishra A, Mishra A, Chattopadhyay P.(PubMed)
(3) Effects of Calendula Essential Oil-Based Cream on Biochemical Parameters of Skin of Albino Rats against Ultraviolet B Radiation by Mishra AK, Mishra A, Verma A, Chattopadhyay P.(PubMed)
(4) Calendula extract: effects on mechanical parameters of human skin by Akhtar N, Zaman SU, Khan BA, Amir MN, Ebrahimzadeh MA. (PubMed)
(5) Brain-Skin Connection: Stress, Inflammation and Skin Aging by Ying Chen* and John Lyga. (PMC)

Herbal Anise, the Natural Laxative with No Side Effects

By Kyle J. Norton, Master of Nutrition

Scientists may have found a natural health food for the treatment of constipation, some studies suggested.

Constipation is a condition of the digestive system characterized by the infrequent of bowel movements due to hard and dry of the stools.

Most people with long-term constipation experience symptoms of abdominal pain, bloating and feeling of not completely passed the bowel movement. 

Untreated or a prolonged period of constipation is associated with the complications of hemorrhoids, anal fissure or fecal impaction.

Constipation is the most common gastro disorders in the US. According to Self-reported constipation, about 2% of the population describe constant or frequent intermittent episodes of constipation. 

Women and adults ages 65 and older are at a higher risk of constipation.

Laxative is the primary treatment of patients with long-term constipation. However, long-term intake of the substances can adduct the function of bowel natural movement. 

Some researchers cautioned that laxative may cause side serious side effects, including bloody stools. severe cramps or pain, weakness or unusual tiredness, sometimes rectal bleeding and imbalance of salts and minerals in the body.

If you are currently using laxative please make sure you know all the side effects and how to deal with them, including the interreaction of laxative with other medications.

Herbal Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belonging to the family Apiaceae native to Egypt and the Mediterranean region.

The popular herb has been used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, antiseptic, anti-spasmodic, carminative, digestive, expectorant, stimulant, and tonic agent to treat head-lice and mites, increase blood pressure, prevent formation of gas in the gastrointestinal tract and menstrual cramps, etc.

Ingredients
Besides the main ingredient Anethole, it also contains, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

Anise has been used as a laxative in assisting bowel movement in folk medicine worldwide, especially in Asia.

In the study to reaffirm the traditional use of herbal Anise for the treatment of constipation, researchers at the Universidade Federal do Rio Grande do Su, conducted an experiment to examine the effects of a phytotherapeutic formula in Brazil.

The formula contains Pimpinella anisum L.(Anise), Foeniculum vulgare Miller, Sambucus nigra L., and Cassia augustifolia.

The randomized, crossover, placebo-controlled, single-blinded trial included 20 patients with chronic constipation according to the criteria of the American Association of Gastroenterology. 

Half of the subjects were received the phytotherapic compound for a 5-day period, whereas the other half were received placebo for the same period.

Both treatment periods were separated by a 9-day washout period followed by the reverse treatment for another 5-day period.

After examining the two phases of the reported constipation questionnaire and assessing the intestinal transit, straining, stool consistency and sensation of fecal obstruction or incomplete evacuation in the last 24 hours filled by patients on a daily basis, researchers found that patients received the formula show a statistically significant improvement of bowel function, but the quality of life did not show significant differences among the study periods, according to the WHOQOL-Bref.

The phytotherapic compound processed a laxative efficacy and is a safe alternative option for the treatment of constipation.

Further analysis also suggested that the phytotherapic compound is found to exert a small reduction in serum potassium levels during the active treatment.

Observation of clinical variables such as arterial blood pressure, heart frequency, and laboratory data did not show significant changes during the study, an indication of no adverse effects.

Dr. Picon PD, the lead author said, "The findings of this randomized controlled trial allow to conclude that the phytotherapic compound assessed has laxative efficacy and is a safe alternative option for the treatment of constipation".

Taken altogether, herbal Anise used alone or combined with other herbal medicine may be considered an adjunct therapy for treatment of constipation without inducing adverse effects

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Randomized clinical trial of a phytotherapic compound containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifolia for chronic constipation by Picon PD, Picon RV, Costa AF, Sander GB, Amaral KM, Aboy AL, Henriques AT. (PubMed)