Papaya, The Fruit Which Protects Our Body Against Acute and Chronic Inflammatory Diseases

By Kyle J. Norton, Master of Nutrition

Papaya is found to process anti acute and chronic inflammatory activity that may be considered an adjunct therapy for treatment of several chronic diseases, some scientists suggested

Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.

Any inflammation that lasts more than 3 months is considered chronic inflammation.

Truly, the main focus of inflammation is to repair damage and injury.

However, overexpression of inflammatory cytokines in most cases can cause improper healing with scar formation or the death of nearby cells.

Chronic inflammation is the results of the immune system inability to kill off all the microorganism participated in the acute phase of infection, leading to the forming of autoimmune and chronic inflammatory diseases such as RA and diabetes.

Inflammation is also can be caused by overexpression of free radical compared to the antioxidant enzymes in the body. This result can lead to an imbalance of the ratio of the levels of free radicals and antioxidant, the major cause of oxidative stress.

Longer-term oxidative stress in the body can also cause oxidative damage to biomolecules, including lipids, proteins, DNA that initiate the development of numbers of chronic diseases, such as atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction.

Papaya is a species of Carica Papaya, belonging to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries


Chemical constituents
Alkaloids, Cardenolides, Anthraquinones, Saponins, Tannin, phenol, flavonoid, anthocyanin, Benzyl glucosinolate, benzylisothiocyanate, 5-(Hydroxymethyl)-2-furancarboxaldehyde, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and 1,3-dihydroxy-2-propanone, etc.(a)

In the reaffirm fruit and vegetables have therapeutic potential as they dampen inflammation with no known side-effects, researchers at the Universiti Putra Malaysia launched an evaluation to examine the effect of papaya on the activity of Th1 (IFN-γ(+) CD4(+))/Th2 (IL-4(+)CD4(+)) T cells play in mediating inflammatory responses.
According to the flow cytometry methods. application of papaya exerted a potential effect in down-regulation of IFN-γ(+) CD4(+) (p=0.03, n=13) in the expression of inflammatory markers and up-regulation of IL-4(+) CD4(+) (p=0.04, n=13) T cells, CD3(+) CD4(+) CD25(+) CD127(-) in productiuon of anti inflammatroy sytokines.

Tregs, regulatory T cells (Tregs) are a specialized subpopulation of T cells that act to suppress the immune response in the production of the proteins related to inflammation, were found after papaya consumption.

In vitro cultures, papaya up-regulates Tregs in male subjects and was significantly associated with suppression of the levels of IL-1β and other inflammatory cytokines.

Dr. Abdullah M., the lead author said, "Papaya consumption may exert an anti-inflammatory response mediated through Tregs and have potential in alleviating inflammatory conditions".

Furthermore, in the reconfirmation of papaya anti-inflammatory effect in patients with sepsis, a serious unbalanced hyperinflammatory condition, researchers found that pretreatment of mangiferin (MF), a natural glucosyl xanthone found in papaya inhibits sepsis-activated mitogen-activated protein kinases and nuclear factor kappa-light-chain-enhancer of activated B cells signaling, the mediators with function in stimulated the production of  in elevated inflammatory cytokines.

Moreover, MF dose-dependently also up-regulates the expression and activity of heme oxygenase (HO)-1 which plays a critical role in the prevention of vascular inflammation in the lung of septic mice, leading to the elimination of the septic lung injury.

The findings suggested that MF attenuates sepsis by up-regulation of HO-1 that protects against sepsis-induced ALI through inhibiting inflammatory signaling and proinflammatory mediators

Taken all together, papaya and its bioactive compound mangiferin (MF)  may be an adjunct therapy combined with conventional medicine for treatment in acute and chronic inflammatory diseases.




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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(a) Chemical composition and bioactivity of dried fruits and honey of Ficus carica cultivars Dottato, San Francesco and Citrullara by Loizzo MR1, Bonesi M, Pugliese A, Menichini F, Tundis R.(PubMed)
(1) Carica papayaincreases regulatory T cells, and reduces IFN-γ+ CD4+ T cells in healthy human subjects by Abdullah M1, Chai PS, Loh CY, Chong MY, Quay HW, Vidyadaran S, Seman Z, Kandiah M, Seow HF. (PubMed)
(2) Anti-inflammatory effects of mangiferin on sepsis-induced lung injury in mice via up-regulation of heme oxygenase-1 by Gong X1, Zhang L, Jiang R, Ye M, Yin X, Wan J.(PubMed)

How to Block the Onset of Oral Diseases Naturally

Kyle J. Norton, Master of Nutrition

Scientists may have found a phytochemical isolated from carrots which processes a significant potential in acting as a nonsurgical aid in the treatment of oral diseases, some studies suggested.

Oral diseases are groups of a medical condition, including dental cavities, periodontal (gum) disease, oral cancer, oral infectious diseases, trauma from injuries, and hereditary lesions.

Some researchers suggested that oral health is an important part of your overall health.

The Ireland dental Health Association in the article Links between oral & general health wrote, "A healthy mouth enables not only nutrition of the physical body, but also enhances social interaction and promotes self-esteem and feelings of well-being" and "Bacteria from the mouth can cause infection in other parts of the body when the immune system has been compromised by disease or medical treatment".

Therefore, maintaining a healthy oral health may result in reducing the risk which links the oral disease to other health problems such as diabetes, heart disease, and stroke.

Truly, there are some tips that may help you to prevent the oral health problems, including visiting your dentist one to two times a year for a cleaning and checkup. brush your teeth with a fluoride toothpaste a minimum of two times per day, replace your toothbrush or toothbrush head every three to four months and floss at least once per day, according to the article published on health Line.

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

In the aim to find a natural pigment with potential to improve the oral health, researchers at the Swami Devi Dyal Hospital and Dental College conducted an experiment on some of the various classes of pigments in nature, particularly,the pigment lycopene, a red plant pigment found in tomatoes, apricots, guavas, carrots, watermelons, papayas, and pink grapefruits, with tomatoes being the largest contributor to the dietary intake of humans.

Application of lycopene not only exhibits higher antioxidant activity through the ability as a singlet oxygen quenching phytochemical, but also exerts a multifunctional role as a nonsurgical aid in the treatment of oral diseases like leukoplakia, oral submucous fibrosis, lichen planus, oral squamous cell carcinoma, and also prevents the destruction of periodontal tissues.

The findings suggested adding 1 or 2 portions of tomatoes into your daily diet can provide a absolute protection for your oral health.

Furthermore, in the examine the link between chronic periodontitis (CP), a multifactorial infecto-inflammatory disease caused by the interaction of microbial agents present in the biofilm and oxidative stress (OS), an imbalance of the ratio between free radicals and antioxidant enzymes produced by the host body, researchers at the Federal University Rio Grande do Sul conducted a randomised, controlled, double-blind or blind studies to evaluate the effect of selected antioxidant
in chronic periodontitis patients.

Antioxidant including in the study are lycopene, vitamin C, vitamin E, capsules with fruits/vegetables/berry.

At the final report of the experiment, researchers indicated that only lycopene and vitamin E demonstrated statistically significant improvement when compared to a control group in terms of periodontal parameters.

These results were observed through oxidative stress pattern throughout the study. As only lycopene and vitamin E showed a reduction of the levels of oxidative stress compared to others.

Moreover, in the evaluation of the effect of lycopene along with routine scaling and root planing in terms of changes in clinical parameters and levels of circulating tumor necrosis factor alpha (TNF-α), salivary interleukin 1beta (IL-1ß), and uric acid in chronic periodontitis, researchers launched a randomized, placebo-controlled, parallel design, double-blinded trial in a total of 42 subjects/

Out of 42 subjects were assigned to the test group (n = 21) received 8 mg lycopene/day and placebo group (n = 21) along with adjunctive scaling and root planing. Patients were monitored at baseline and at 2 months after therapy.

At the end of the study, researchers found that test group (Lycopene) showed better results after therapy compared to the placebo group with all assays, including Periodontal parameters regarding plaque index (PI), modified gingival index (MGI), bleeding on probing (BOP).

Although the serum TNF-α value, the pro-inflammatory cytokine was not statistically significant, it, however, showed an improvement compared to the placebo group.

Taken all together, tomato and carrot processed abundant phytochemical lycopene may be an adjunct therapy combined with conventional medicine for prevention and treatment of oral diseases.

Therefore, adding 2 or 3 portions of tomatoes or carrots or intake of lycopene supplement, according to the guideline on a regular basis may give you a perfect breath and oral health.

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Role of Lycopene in Preventing Oral Diseases as a Nonsurgical Aid of Treatment by Gupta S1, Jawanda MK2, Arora V3, Mehta N4, Yadav V(PubMed)
(2) The impact of antioxidant agents complimentary to periodontal therapy on oxidative stress and periodontal outcomes: A systematic review by Muniz FW1, Nogueira SB2, Mendes FL3, Rösing CK4, Moreira MM5, de Andrade GM6, Carvalho Rde S(PubMed)
(3) The adjunctive use of systemic antioxidant therapy (lycopene) in nonsurgical treatment of chronic periodontitis: a short-term evaluation by Arora N1, Avula H, Avula JK(PubMed)

White Button Mushroom Which inhibits the Onset of Prostate cancer

By Kyle J. Norton, Master of Nutrition

White button mushroom may be considered a functional food in inhibiting the early onset of prostate cancer, some scientist found.

Prostate cancer is cancer originated from the inner lining of the prostate gland caused by irregular prostate cell growth. Prostate cancer is a slow growing cancer. However, they can be deadly in the advanced stage by traveling a distance away to infect other healthy tissue and organs.

Most prostate cancers are found in the yearly annual physical exam, designed for the male at a higher risk of prostate cancer.

The exact causes of prostate cancer are unknown. However, the most common risk factor associated with the onset of the disease is genetic mutation inherited from the parents. mutation of BRCA1 and BRCA2 reserves the function of tumor suppressor genes which normally repair mistakes in a cell's DNA to allow DNA mutation of the prostate cells.

Other risk factors also include age, family history, ethnicity and longterm exposure to organ agents.

Unhealthy diet and lifestyle are also the most common preventable risk factors for the onset of the disease.

Dr. Sandaly O. S. Pacheco,, the lead author in the study "Food Habits, Lifestyle Factors, and Risk of Prostate Cancer in Central Argentina: A Case-Control Study Involving Self-Motivated Health Behavior Modifications after Diagnosis" wrote, "(Patients diagnosed with prostate cancer have) a greater mean consumption of meats and fats and lower intakes of fruits, green vegetables, cruciferous vegetables, legumes, nuts, seeds, and whole grains than the controls (all p < 0.001)".

Therefore, reducing the intake of meats and fats, and actively engaging in the dietary modifications with increased consumption of fish, fruits (including red fruits in prostate cancer), cruciferous vegetables, legumes, nuts, and black tea may reduce the risk of prostate cancer.

Mushroom is a standard name of white button mushroom, the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source.

 It is a genus A. Muscaria and belonging to the family Amanitaceae and has been recultivated in many cultures all over the world for foods and health benefits.

Chemical constituents
Astraodorol, Psilocybin, Lectin, adustin, ribonuclease, nicotine, 2-hydroxy-4-methoxy-6-methylbenzoic acid, orsellinic acid, melleolide, ergosterol, genistein, daidzein, daucosterol, genistin, uracil, and D-mannitol.

In the evaluate the effects of white button mushroom extract and its major component, conjugated linoleic acid (CLA) on prostate cancer cell lines in vitro and mushroom extract in vivo, researchers found that

* Injection of mushroom effectively inhibits cell proliferation in a dose-dependent manner and induces apoptosis of the tested cell lines within 72 h of treatment.

* Application of CLA inhibits proliferation in the prostate cancer cell lines in vitro.

* DU145 and PC3 prostate tumor size and tumor cell proliferation are decreased in nude mice treated with mushroom extract, whereas tumor cell apoptosis was increased compared to pair-fed controls.* Application of mushroom in tested mice demonstrated the significant changes in the tumor gene expression compared to controls, according to microarray analysis.

Dr. Adams LS the lead author said, "..., the anticancer potential of phytochemicals in mushroom extract both in vitro and in vivo and supports the recommendation of white button mushroom as a dietary component that may aid in the prevention of prostate cancer in men".

Furthermore, in the study to examine whether Mushrooms, an excellent source of dietary vitamin D2 in the risk of prostate cancer, researchers launched a nested case-control study based on a 13-year follow-up of about 19,000 middle-aged men who attended the first screening visit within the Helsinki Heart Study and free of clinically verified prostate cancer at baseline.

According to record linkage with the files of the Finnish Cancer Registry, 149 prostate cancer cases were identified in the cohort.

After the assessment, researchers found that

* Prostate cancer risk, analyzed by quartiles of the 25-VD levels, was inversely related to 25-VD. In other words, men with a 25-VD concentration below the median are associated with the risk of prostate cancer compared to men with the 25-VD level above the median.

* The prostate cancer risk was highest among younger men (<52 years) at entry and low serum 25-VD (OR 3.1 nonadjusted and 3.5 adjusted).

* The mean age at diagnosis of the patients with a 25-VD concentration above the median was 1.8 years higher than that of patients with vitamin D below the median (63.1 vs 61.3 years).

These results strongly suggested that low levels of plasma 25-VD concentration are a prevalent risk factor of the onset of prostate cancer. In other words, increased consumption of mushroom can increase and maintain blood levels of 25-hydroxyvitamin D in a healthy range, thus reducing the risk of prostate cancer, regardless of age group.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) [Chemical constituents from fungus Armillaria mellea]. by [Article in Chinese] by Yuan XL1, Yan LH, Zhang QW, Wang ZM.(PubMed)
(1) Prostate Cancer (Health tips for better living and living health)
(2) White button mushroom (Agaricus bisporus) exhibits antiproliferative and proapoptotic properties and inhibits prostate tumor growth in athymic mice by Adams LS1, Phung S, Wu X, Ki L, Chen S.(PubMed)
(3) Photobiology of vitamin D in mushrooms and its bioavailability in humans by Keegan RJ, Lu Z, Bogusz JM, Williams JE, Holick MF. (PubMed)
(4) Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland) by Merja H. Ahonen, Leena Tenkanen, Lyly Teppo, Matti Hakama, Pentti Tuohimaa (Springer link)

Garlic, The Kitchen Spice in the Prevention and Treatment of Hypertension, Scientists Recommend

By Kyle J. Norton, Master of Nutrition

Scientists may have found a common kitchen spice with a potential in reducing high blood pressure quickly without including any side effects, some studies endorsed.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

High blood pressure means raising the pressure in your heart. If it stays high over time it can damage the body in many ways.

The causes of hypertension are unknown. However, researchers do know that acute hypertension is induced by daily stress.

Certain risk factors such as unhealthy lifestyle choices, physical inactivity unhealthy diet with high in saturated and trans fat, refined products, processed food, high sugar, and salt intake,...... over time cause your blood pressure to spice-up chronically.

Lifestyle choices can also lead to overweight or obese, the risk factors for the early onset of hypertension.

According to the statistic, in the US, over 75 million adults or 32% have high blood pressure.

In other words, 1 in every 3 American adults has the syndrome. Sadly 44% of the mentioned adults with high blood pressure are not under control.

Uncontrol high blood pressure has long been known as a major risk factor for the development of heart disease and stroke, the leading causes of death in the United States.

Blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects such as gastrointestinal discomforts, tiredness, weakness, headache.

Some patients who are taking the hypertensive medicine over the prolonged periods of time may experience symptoms of erectile dysfunction.

In severe cases, intake of antihypertensive drugs for a long term can cause dermatitis, arthritis and anemia and lupus erythematosus-like syndrome, according to the article "Adverse Effects of Antihypertensive Drugs" written by Dr. DWARD D. FREIS, M.D.

If you are currently taking any anti-high blood pressure medications, please make you that you know all the side effects.

Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia.

The kitchen spice has been used popularly in traditional and Chinese medicine in treating common cold and flu, blood pressure cholesterol levels, natural antibiotic, etc.

In adult men and women, participated in the Tehran Lipid and Glucose Study (2006-2008 to 2012-2014), intake of garlic is associated to reduce the risk of hypertension by up 26%.

In hypertension of 80-90% patients with excess glucocorticoid level, allicin found in garlic attenuated dexamethasone-induced anorexia and loss of total body weight.

A randomized, placebo-controlled, clinical trial conducted on 56 CVD patients, aged 25 - 75 years old also suggested treatment with garlic-based drugs can be effective for controlling BP in CVD patients and has no interaction with other drugs that CAD patients take, after 3 months of the administration.

Dr. Takashima M the lead author at the Wakunaga Pharmaceutical Co. Ltd said, " aged garlic extract (AGE) is effective in reducing the blood pressure of hypertensive patients,......AGE-induced the concentration-dependent vasorelaxation of isolated rat aortic rings that had been precontracted with norepinephrine"

In fact, The traditional Chinese medicine, food therapy, and hypertension control, all recommended that garlic is of the food to be used for hypertension control, according to a statistical analysis of antihypertensive foods recommended in 20 books on the application of food therapy for hypertension control.

 If you can control your diet, make changes to lifestyle, maintaining an ideal weight, you could do just fine without the drugs,

Taking all together, garlic may be used as preventive and controlling effects for patients with or without high blood pressure. Some researchers insisted that garlic anti hypertension effect may result from its anticoagulant property.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats by Dubey H1,2, Singh A1, Patole AM2, Tenpe CR2(PubMed)
(2) Allium vegetable intakes and the incidence of cardiovascular disease, hypertension, chronic kidney disease, and type 2 diabetes in adults: a longitudinal follow-up study by Bahadoran Z1, Mirmiran P, Momenan AA, Azizi F.(PubMed)
(3) Does Garlic Supplementation Control Blood Pressure in Patients with Severe Coronary Artery Disease? A Clinical Trial Study by Mahdavi-Roshan M1, Nasrollahzadeh J1, Mohammad Zadeh A2, Zahedmehr A3. (PubMed)
(4) Traditional Chinese Medicine, Food Therapy, and Hypertension Control: A Narrative Review of Chinese Literature by Zou P1(PubMed)
(5) The anticoagulant rivaroxaban lowers portal hypertension in cirrhotic rats mainly by deactivating hepatic stellate cells by Vilaseca M1,2, García-Calderó H1,3, Lafoz E1,2, García-Irigoyen O3,4, Avila MA3,4, Reverter JC5, Bosch J1,2,3,6, Hernández-Gea V1,3, Gracia-Sancho J1,2,3, García-Pagán JC1,2,3(PubMed)

Green tea, The Beverage Which Ameliorates Symptoms and Treats Depression and Anxiety Disorders

Kyle J. Norton

Green tea may have a potential and positive effect in reducing symptoms of depression and anxiety stress, some scientists suggested.

Depression and anxiety disorders are a psychological illness. Depression disorder is not the same as anxiety disorder however they often share symptoms similar to those of an anxiety.

The causes of depression may be attributed to the numbers of factors such as genetics, changes in hormone levels, certain medical conditions, stress, grief or difficult life circumstances.

In anxiety, risk factors that associated to the early onset of the disease are family history, long-term under stressful situations and excessive alcohol drinking and use of tobacco, particularly in people who had a childhood history of being abused. 

The Mayo Clinic in the classification of anxiety suggested that women are twice as likely as men to experience a generalized anxiety disorder (GAD).

In the comparison of the symptoms of depression and anxiety, one may find several overlaps, including symptoms of sleep problems, trouble concentrating, and fatigue.

Dr. Kathleen Smith, Ph.D. in the classification of the different depression and anxiety wrote, "There are, however, some distinguishing features. People with depression move slowly, and their reactions can seem flattened or dulled. People with anxiety tend to be more keyed up, as they struggle to manage their racing thoughts. Another distinguishing feature is the presence of fear about the future in people with anxiety. Depressed people who do not have anxiety are less likely to be fraught with worry about future events, as they are often resigned to believing that things will continue to be bad. In other words, they may predict the future based on how they feel in the moment".

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.
The National University Health System, Singapore which launched the study to examine the association between long-term tea consumption and depressive and anxiety symptoms in community-living elderly including 614 elderly aged 60 years and above, who were free of dementia and cognitive impairment suggested base on the Information on tea consumption,
* 59% of the subjects participated in the study had consumed tea for over 15 years.

* Long-term tea consumption was significantly associated with a reduced odds of having depressive and anxiety symptoms, after adjusting for demographics (i.e., age, gender, education, and ethnicity), comorbid conditions (i.e., heart disease, diabetes, stroke, hypertension, and hyperlipidemia) and long-term coffee consumption.

The findings suggested that long-term tea consumption was associated with reduced depressive and anxiety symptoms among community-living elderly. and that may be the reason that tea's bioactive compounds are used in promoting mental health in aging.

Furthermore, in the evaluate the anti-stress effect of green tea with lowered caffeine, low-caffeine green tea, on humans in a single-blind group comparison and participants (n=20) randomly assigned to low-caffeine or placebo tea groups, researchers showed that according to the state-trait anxiety inventory test.
* The subjective stress in participants was significantly lower in the low-caffeine-group than in the placebo-group during pharmacy practice.

* The level of salivary α-amylase activity, a stress marker, increased significantly after daily pharmacy practice in the placebo group but not in the low-caffeine-group.

These results suggested that the ingestion of low-caffeine green tea suppressed the excessive stress response of students.

Moreover, in the review of a systematically searched on PubMed database and selected studies by predefined eligibility criteria, researcher indicated that in out of 21 studies selected, 4 of which were randomized controlled trials, 12 cross-over studies (both assessed with an adapted version of the DELPHI-list), 4 were cross-sectional studies and one was a cohort study

* Green tea intake exerts a significant influence on the psychopathological symptoms (e.g. reduction of anxiety), cognition (e.g. benefits in memory and attention) and brain function (e.g. activation of working memory seen in functional MRI). 

* The effects of green tea is not attributed to a single constituent of the beverage, but the combined influence of both caffeine and l-theanine, whereas separate administration of either substance was found to have a lesser impact.

Taken all together, there is no doubt, standard green tea may be considered a functional food in ameliorating the symptoms of depression and anxiety disorders.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Associations of Long-Term Tea Consumption with Depressive and Anxiety Symptoms in Community-Living Elderly: Findings from the Diet and Healthy Aging Study by Chan SP1, Yong PZ, Sun Y, Mahendran R, Wong JCM, Qiu C, Ng TP, Kua EH, Feng L.(PubMed)
(2) Green tea effects on cognition, mood and human brain function: A systematic review by Mancini E1, Beglinger C2, Drewe J2, Zanchi D1, Lang UE1, Borgwardt S3(PubMed)
(3) Anti-stress Effect of Green Tea with Lowered Caffeine on Humans: A Pilot Study by Unno K1,2, Yamada H3, Iguchi K1, Ishida H4, Iwao Y5, Morita A6, Nakamura Y2.(PubMed)

Asparagus, The Veggie Which Causes Cytotoxicity on Cancers

By Kyle J. Norton, Master of Nutrition

Scientists may have found a whole food with the potential to kill cancer cells before they can cause some serious effect on the human body, some studies suggested.

Cancer is the group of diseases characterized by cell growth disorderly and uncontrollably in some tissue and organs, due to the alternation of cell DNA.

At the advanced stage, most invasive cancerous cells can travel a distance away from the original site to infect other healthy tissue and organs through the circulation of blood and fluid.

The causes of cancer are unknown, researchers do not why people with the same health conditions and family history, some are susceptible to the onset of the diseases while others do not.

However, they do know that smoking, radiation, viruses, cancer-causing chemicals (carcinogens), obesity, hormones, chronic inflammation and a lack of exercise are most risk factors associated to the early onset of cancers.

Furthermore, genes mutation such as BRCA1 and 2 inherited from the parents are one of the major risk factors that cause cancers.

Long-term excessive alcohol drinking is associated with a higher risk of liver cancer.

According to the World Cancer Research Fund, Eating 'fast foods' (such as chips and fried chicken) or other processed foods that are high in fat and sugar (like chocolate, crisps, and biscuits) can make you gain weight, and there is strong evidence that being overweight or obese is a cause of 12 types of cancer. And diets that are high in plant foods – such as fruit, vegetables, whole grains, and beans – can help you stay a healthy weight, and may also protect against certain cancers.

Moreover, Dr. Weiderpass E, in the study of "Lifestyle and cancer risk" wrote. "The main behavioral and environmental risk factors for cancer mortality in the world are related to diet and physical inactivity, use of addictive substances, sexual, and reproductive health, exposure to air pollution and use of contaminated needles".

Asparagus is a flowering plant belonging to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa, and western Asia.

Asparagus has been used from early times as a vegetable and medicine, because of its delicate flavor and diuretic properties.

Its chemical constituents include essential oils, asparagine, arginine, tyrosine, flavonoids (kaempferol, quercetin, and rutin), resin, and tannin.


In the study of saponins from old stems of asparagus (SSA) potential inhibitory activity on tumor growth and metastasis conducted by the East China Normal University on the breast, colon and pancreatic cancer cell lines, researchers found that
* Injection of saponins displays a significant effect in the inhibition of all tested cancer cell lines in a concentration-dependent manner, with half-maximum inhibitory concentrations ranging from 809.42 to 1829.96 µg mL(-1).

* At the concentration of 400 µg mL(-1), SSA is more functional in blocking cell migration and invasion as compared with its cytotoxic effect.

* Furthermore, SSA markedly increased the activities of Cdc42, a protein with function involved in the regulation of the cell cycle. and Rac1 with function in stimulating the cytotoxicity activity and decreased the activity of RhoA that is associated with cytoskeleton regulation, in cancer cells.

These results suggested that SSA increased the levels and activities of reactive oxygen species in exerting cytotoxicity against the proliferation and migration of cancer cells.

Dr.Wang J, the lead scientist at the final report, said, "SSA inhibits tumor cell motility through modulating the Rho GTPase signaling pathway (in the regulation of diverse cellular functions), suggesting a promising use of SSA as a supplement in healthcare foods and natural drugs for cancer prevention and treatment".

Moreover, in the examine the function of a series of Sarsapogenin and Diosgenin derived steroidal constituents (1-12), isolated from Solanum xanthocarpum and Asparagus racemosus against cancers, researchers showed that the isolated compounds exert their ability to induce cell death and apoptosis of colon carcinoma cells. 

The carbohydrate moieties linked to the steroid backbones process the strong influence in the induction of cytotoxic activity and cell death mode (apoptosis or necrosis). 

Taken all together, asparagus containing high amounts of saponins and newly Sarsapogenin and Diosgenin derived steroidal constituents may be considered a functional food for the prevention and treatment of cancers.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) Chemical constituents of Asparagus J. S. Negi, P. Singh, [...], and V. K. Bisht (PubMed)
(2) Saponins extracted from by-product of Asparagus officinalis L. suppress tumor cell migration and invasion through targeting Rho GTPase signaling pathway. by Wang J, Liu Y, Zhao J, Zhang W, Pang X.(PubMed)
(3) Apoptosis-inducing activity of steroidal constituents from Solanum xanthocarpum and Asparagus racemosus. by Bhutani KK, Paul AT, Fayad W, Linder S.(PubMed)

Green Tea Protects the Child Joints Against the Onset of Juvenile Arthritis

By Kyle J. Norton, Master of Nutrition


Green tea may have a therapeutic and positive effect in reducing risk, progression, and treatment of juvenile arthritis, some scientists suggested.

Juvenile arthritis is an inflammatory disease affecting the synovium in children aged 16 or younger.

In other words, it is an autoimmune disorder caused by the immune system attacks some of the body's own healthy cells and tissues, in this case, the immune system attacks the joint tissue in the juvenile.

Genes that are associated with the risk of juvenile idiopathic arthritis include HLA-A. HLA-B. HLA-DPB1. HLA-DQA1. HLA-DQB1. HLA-DRB1. IL2RA. IL6, according to the National Institute of Health.

According to the statistic, the most common form of juvenile idiopathic arthritis (JIA), affects over 50,000 children in the United States alone.

Juvenile Arthritis shares the common symptoms of adult arthritis, including pain, stiffness, swelling, fever, skin rash and in the serious case. The condition can also cause some complications such as pericarditis, hemolytic anemia, macrophage activation syndrome (MAS), and endarteritis

In the article "Juvenile Arthritis: Early Signs and Symptoms" By Susan Bernstein wrote, "Juvenile arthritis includes many different diseases, but one common thread between them is that they can have serious, even life-threatening impacts on a young child".
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

In the investigation of the effect of green tea extract on the oxidative state of the liver and brain of adjuvant-induced arthritic rats, a model for human rheumatoid arthritis with daily doses of 250 mg kg(-1) (59.8 mg catechins per kg) for 23 days, researchers at the State University of Maringá, found that treatment group expressed a significant activity in reducing the protein and lipid damage in liver, brain, and plasma, caused by ROS expression in induction of oxidation which has been found with associated to the progression of arthritis.

Injection of green tea extract also enhanced the overexpression of antioxidant defenses, found in low levels in patients with arthritis through restoration of the glutathione (GSH) associated to the important function in preventing damage to important cellular components caused by reactive oxygen species and protein thiol levels in reducing cellular oxidation through chelative and detoxified activities and improved natural antioxidant enzymes, produced by the body.

Furthermore, green tea extract also inhibited the levels of glucose 6-phosphate dehydrogenase, which is increased in the liver in patients with arthritis, one of the major risk factor for the development of arthritis.

These results suggested that application of green tea exerted a significantly profound effect in the liver and brain of patients suffering from rheumatoid arthritis through reduced overexpression of oxidative stress in precipitated injury to lipids and proteins.

Some researchers suggested that by modifying the metabolic function in lipid and protein, green tea extract exhibited a strong protective effect in reducing the symptoms and progression of arthritis.

According to the study of University of Health System of green tea effect in patients with rheumatoid
arthritis, injection of green tea extract demonstrated a therapeutic effect in patient's synovial fibroblast of the lining tissue which surround the capsule of the joint by inhibiting the production of IL-1B, a prototypic proinflammatory cytokines in response to acute and chronic inflammation. Overexpression of IL-1B is associated with the contribution of joint damage.

Interestingly, in the study of adolescent male Wistar rats 12-week exposure to Cd and Pb (7mg Cd and 50mg Pb in 1kg of the diet randomly assigned to 12 to each group, as positive control received without Cd, Pb and teas, a negative control group received Cd and Pb, and groups supplemented additionally with green (GT), black (BT), red (RT), and white tea (WT), researchers indicated that application of tea significant inhibits the decreased levels of the geometric(shape) and densitometric(density) parameters and total thickness of articular cartilage caused by Cd and Pb in compared to the negative control group.

Tea injection group also displayed a huge improvement in mechanical endurance, growth plate thickness, and trabecular histomorphometry depending on the tea type.

Due to the limitation of the study, Dr. Tomaszewska E, the lead researcher said, " It is difficult to indicate which tea has the best protective effects on bone and hyaline cartilage against heavy metal action".

More importantly, in the examine some major factors in contributing juvenile arthritis, green tea rich in catechins (Healthy green tea) in animal study, green tea injection restored these biomarkers of cytokine genes (IL-1A, IL-2, IFN-alpha, FGF-alpha, TNF-alpha) to near normal levels, thus preventing or attenuating the development of a certain type of inflammatory arthritis.


Taken all together, green tea and its bioactive polyphenols may be considered a functional food for reduction of the early onset, progression and combined with standard therapy for treatment of juvenile and adult arthritis.

However, the intake of green tea supplement should be taken with exceptional care as acute liver toxicity has been reported in numbers of medical literature.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea extract improves the oxidative state of the liver and brain in rats with adjuvant-induced arthritis by de Almeida Gonçalves G1, de Sá-Nakanishi AB, Wendt MM, Comar JF, Bersani Amado CA, Bracht A, Peralta RM. (PubMed)
(2) (Alteration in bone geometric and mechanical properties, histomorphometrical parameters of trabecular bone, articular cartilage, and growth plate in adolescent rats after chronic co-exposure to cadmium and lead in the case of supplementation with green, black, red and white tea by Tomaszewska E1, Dobrowolski P2, Winiarska-Mieczan A3, Kwiecień M3, Tomczyk A4, Muszyński S5, Radzki R4.(PubMed)
(3) Green tea with a high catechin content suppresses inflammatory cytokine expression in the galactosamine-injured rat liver by Abe K1, Ijiri M, Suzuki T, Taguchi K, Koyama Y, Isemura M.(PubMed)