Asparagus, The Whole Food Which Stops the Spreading of Kidney Cancers Cells in Vitro

By Kyle J. Norton, Master of Nutrients

"Let foods be your medicine and let medicines be your food", using foods as the medication has been a dream of many scholars and scientists over the past many centuries.

 In order to achieve these, consumption of whole food medicine must accompany with moderate exercise, change of diet and lifestyle.

Asparagus may be a potential product used for the treatment of renal cell carcinoma caused by recurrent abnormal chromosomes in gene and reciprocal gene expression, some scientists suggested.

Kidney cancer is a medical condition characterized by irregular and disorder cell growth arose first at kidney lining tissue before invading to the deep layers of the .kidney.

At the advaced stage of kidney cancer, the malignant cells can travel a distance away from the kidney to infect other healthy tissue and organs, through blood and fluid circulation.

The exact causes of kidney cancer are unknown. Researchers also do not know why, people with the same gene inherited from the same parents, some are susceptible to the onset of the disease, while other off-springs do not.

However, researchers do not that certain risk factors such as smoking obesity, chemical exposure, gender and family history are some the prevalent risk factor that can manifest the onset of kidney cancer.

Long-term intake of certain medicines such as diuretics and analgesic pain pills, such as aspirin, acetaminophen, and ibuprofen and medical conditions such as advanced kidney disease and hypertension are associated with kidney cancer develops.

Furthermore, according to the information provided by the American Cancer Society, people born with the mutation of a gene (FH) linked to hereditary leiomyoma and the SDHB and SDHD genes are also at a higher risk to the cancer onset.

Asparagus is a flowering plant belonging to species of the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa, and western Asia.

The delicious plant has been used from early times as a vegetable and medicine, because of its delicate flavor and diuretic properties.

According to the Banaras Hindu University, asparagus racemosus leaf extract inhibits growth UOK 146 renal cell carcinoma through cytotoxic activity and downgraded the process of genes responsible for proliferation of the UOK146 cell line.

Dr. Verma SP, the lead author said, " Evidence of antiproliferative effect, PRCC-TFE3(recurrent abnormal chromosomes in gene and reciprocal gene expression) fusion transcript inhibition and static anti- or pro-apoptotic regulators(BAX0 level clearly indicate that AR extract provides or elicits an apoptosis independent anticancer effect on RCC cells by some specific mechanism of regulation"

Renal cell carcinoma (Kidney cancer/renal cells) is a type of kidney cancer caused by malignant cells of the lining of the tubules in the kidney. It tends first to spread via bloodstream and the second tumor generally found in the lung, but it may also spread to lymph nodes and other organs as well.

Shatavarins (containing shatavarin IV) isolated from the roots of Asparagusracemosus exerted anti-cancer properties, in vivo against numbers of cancer cell lines, including A-498 (human kidney carcinoma) cell lines.

Oral administration of shatavarin to tumor-bearing mice at doses of 250 and 500 mg/kg body weight for 10 days,, inhibited tumor cell volume and increased non-cancer cell count, through its potent cytotoxicity, compared to the untreated mice of the EAC control group.

The herbal decode also restored the normal expression of red (RBC) and white blood cell (WBC) counts and hemoglobin (Hb) concentration which are altered in patients with renal cell cancer.

There is no doubt that Asparagus has exhibited significant anticancer activity in both in vitro and in vivo experimental models but further multi and large size studies are necessary to confirm this potency.

However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of asparagus anti-kidney cancer possibilities.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay by Medendorp K1, van Groningen JJ, Vreede L, Hetterschijt L, Brugmans L, van den Hurk WH, van Kessel AG. (PubMed)
(2) Transformation capacities of the papillary renal cell carcinoma-associated PRCCTFE3 and TFE3PRCC fusion genes by Weterman MA1, van Groningen JJ, den Hartog A, Geurts van Kessel A.(PubMed)
(3) Asparagus racemosus leaf extract inhibits growth of UOK 146 renal cell carcinoma cell line: simultaneous oncogenic PRCCTFE3 fusion transcript inhibition and apoptosis independent cell death by Verma SP1, Tripathi VC, Das P.(PubMed)
(4) Shatavarins (containing Shatavarin IV) with anticancer activity from the roots of Asparagus racemosus by Mitra SK1, Prakash NS, Sundaram R.(PubMed)

Beware of Drug Interaction of Green tea and Green Tea Extract, Scientists Warn

Kyle J. Norton

Green may have processed a drug interaction property that inhibits the effect of conventional medicine, some scientists suggested.

Drug interactions are the greatest concern of some scientists, particularly in the pharmaceutical community as these effects can potentially reduce the desired effects for the treatment of certain diseases.

Intake of some drugs together, can reduce the absorption or increase the metabolism or elimination of other drugs treatment potential.

Some drugs interaction can cause an allergic reaction from skin rash and itching to a life-threatening anaphylactic reaction.

If you are taking some drugs for the treatment of certain diseases, please make sure that you know some may interact with the others.

The Havard health in the article "7 things you can do to avoid drug interactions"(4) suggested that you

1. Know why you are taking each medication

2. Know how to take the drug

3. Fill all your prescriptions at the same pharmacy

4. Are suspicious of supplements

5. Go easy on grapefruit juice

6. Limit intake of alcohol

7. Talk to your pharmacist

Green tea is a precious drink processed numbers of health benefit known to almost everyone in Asia and the Western world.

In the review the summarizes published in vitro, animal, and clinical studies investigating the effects of green tea (Camellia sinensis) extract and associated catechins on drug-metabolizing enzymes and drug transporters, researchers at the Prince Sattam Bin Abdulaziz University, Al-Kharj suggested that

* Green tea extract and its main catechin, (-)-epigallocatechin-3-gallate, to varying degrees, inhibit the activity of the cytochrome P450 superfamily of enzymes of CYP1A1, CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2D6, and CYP3A4. UGT1A1 and UGT1A4 but not the major cytochrome P450 enzyme, in vitro
Where cytochrome P450 enzymes have a unique function in metabolizing potentially toxic compounds, including drugs and products of endogenous metabolism. 

* A clinical study, the organic anion transporting polypeptide 1A1 transporter with the potential role of liver transporters and bile acids is also inhibited by (-)-epigallocatechin-3-gallate while P-glycoprotein, the multidrug resistance protein 1 (MDR1) is unaffected

These results suggested that patients should be cautious that consumption of significant amounts of green tea beverages or green tea extract may interact with the substrates of organic anion transporting polypeptide as mentioned above.

Further to investigate the effects of green tea extract (GTE) and (-)-epigallocatechin-3-gallate (EGCG) on the pharmacokinetics of a non-selective hydrophilic β-blocker nadolol, which is reported to be a substrate for several drug transporters and is not metabolized by cytochrome P450 enzymes launched a study o the. male Sprague-Dawley rats.

The tested animals were given GTE (400 mg/kg), EGCG (150 mg/kg) or saline (control) by oral gavage, 30 min before a single intragastric administration of 10 mg/kg nadolol.

At the end of the experiment, researchers showed that

* Pretreatment with GTE resulted in marked reductions in the maximum concentration (Cmax) and area under the time-plasma concentration curve (AUC) of nadolol by 85% and 74%, respectively, compared with control.

* EGCG alone significantly reduced Cmax and AUC of nadolol.

* The amounts of nadolol excreted into the urine were decreased by pretreatments with GTE and EGCG, while the terminal half-life of nadolol was not different among groups.

These results suggest that the coadministration with green tea catechins, particularly EGCG, causes a significant alteration in the pharmacokinetics of nadolol, possibly through the inhibition of its intestinal absorption mediated by uptake transporters.

Taken all together, green tea, green tea extract (GTE) and (-)-epigallocatechin-3-gallate (EGCG) can interact with the drug-metabolizing enzymes and drug transporters including nadolol. 

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of green tea extract and (-)-epigallocatechin-3-gallate on pharmacokinetics of nadolol in rats by Misaka S1, Miyazaki N, Fukushima T, Yamada S, Kimura J.(PubMed)
(2) An Appraisal of Drug-Drug Interactions with Green Tea Albassam AA1, Markowitz JS2.(PubMed)
(3) Effects of green tea extract on the pharmacokinetics of quetiapine in rats by Ezzeldin E1, Asiri YA2, Iqbal M1. (PubMed)
(4) 7 things you can do to avoid drug interactions by Harvard Health

Green Tea And Its Bioactive Polyphenols Which inhibits Fibromyalgia Caused by Sleep Disturbance

By Kyle J. Norton, Master of Nutrition


Green tea may have a therapeutic and positive effect in reduced onset, progression and treatment of fibromyalgia caused by sleep disturbance, some scientists suggested.


Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain affecting over 10 million (3.6% of the population) people in the US alone.

Sleep disturbances are the symptoms of physical, mental, and spiritual problems. The major causes of sleeplessness and insomnia.

Insomnia, a  short-term sleep disturbance affects about 30% of adults and chronic insomnia by 10%, according to the statistic provided by the American Sleep Association.

Some researchers suggested that long-term untreated sleep disturbance is a major cause of stroke and heart disease. Dr. Dae Lim Koo, the lead author in the explanation of some risk factor of stroke, wrote, "Any causes of sleep curtailment or fragmentation such as sleep restriction, sleep apnea, insomnia, periodic limb movements during sleep, and shift work, not only impair cardiovascular restoration but also impose a stress on the cardiovascular system" and  "Sleep disturbances have been reported to play a role in the development of stroke and other cardiovascular disorders" 

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.

In the study of sleep disturbance that causes fibromyalgia, Dr. Choy EH suggested that patients with fibromyalgia demonstrated a reduced short-wave sleep and abnormal α-rhythms, suggestive of wakefulness during non-REM (rapid eye movement) sleep compared to the healthy individuals according to the observation of polysomnography.

Furthermore, in healthy participants, the study indicated that sleep deprivation can also cause fibromyalgia-like symptoms such as myalgia, tenderness, and fatigue and suggested that sleep dysfunction might be not only a consequence of pain.

These results showed a strongly correlated condition of sleep disturbance and initiation of chronic fibromyalgia if sleep disorders are left untreated for a prolonged period of time.

Moreover, according to the presentation, long time effect of sleep disturbance may influence alter the pathophysiology of the central nervous system in abnormal pain processing and central sensitization, according to the observation of the neuroimaging of patients with fibromyalgia neural activation compared to a lower pressure-pain threshold in the healthy age-matched and gender-matched individuals.

After taking into account confounders, researchers said, " Improving sleep quality can reduce pain and fatigue, further supporting the hypothesis that sleep dysfunction is a pathogenic stimulus of fibromyalgia".

Moreover, green tea bioactive polyphenols (-)-Epigallocatechin gallate (EGCG) in the evaluation of the chick brain under an acute stressful condition-induced sleep disturbance, researchers found that EGCG attenuates stress behavior with special reference to gamma-aminobutyric acid (GABA), a neurotransmitter with function in sending chemical messages through the brain and the nervous system, and involving in regulating communication between brain cells in stress environment.

Deficiency of is associated with many nervous conditions, including depression, anxiety, and sleep disorders.

Application of EGCG of doses of 50, 100 and 200 microg, intracerebroventricularly exerted a profound effect in suppressing the vocalization which normally occurs during social separation-stress, one of the risk factors of sleep disturbance.

This illustration truly suggested that EGCG reduced the time spent in active wakefulness and induced sleep-like behavior in a dose-dependent manner.

This interaction opinionated that EGCG induced sedation and hypnosis reduced stress hormone production in precipitating sleep distance probably though GABAA receptors in moderation of an acute stress response.

Some researchers suggested that green tea improved symptoms of fibromyalgia by normalizing the levels of GABA (gamma-aminobutyric acid) when came under stress, may have a therapeutic effect in reducing anxiety by relaxing the muscles and the brain. through increasing production of dopamines, serotonin, and alpha waves within the brain in orchestrated the sleep pattern.

These improvements were associated with the interaction of the brain with chemical compounds found in green tea caffeine and L-theanine, suggested by the author.

Taken all together, the findings suggested that green tea and its bioactive polyphenols EGCG and L-theanine may be considered a secondary therapy in reducing risk, progression, and treatment of fibromyalgia caused by a sleep disorder.

However, intake of green tea supplement should be taken with extreme care due to recent reports of acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) The role of sleep in pain and fibromyalgia by Choy EH. (PubMed)
(2) (-)-Epigallocatechin gallate attenuates acute stress responses through GABAergic system in the brain by Adachi N1, Tomonaga S, Tachibana T, Denbow DM, Furuse M.(research gate)
(3) Green Tea Health Benefits To Get You Drinking Healthy! by Abby Hannaford
(4) Sleep Disturbances as a Risk Factor for Stroke by Dae Lim Koo, Hyunwoo Nam, Robert J. Thomas, and Chang-Ho Yun(PMC)

#@ Fennel, The Herb and Plant That Protect Us Against the Onset of Cancer, Scientists Suggest

Kyle J. Norton

Fennel may have a potential and positive effect in protecting healthy cells against mutagenesis, some scientists suggested.

Mutagenesis is an action that causes the alteration of DNA transcripts in organisms caused either by adaptation to the new environment or mutagens. In other words, it is the change in cells genetic information for survival in a new environment or by the invasion of mutagens

In human, the change of genetic information can be classified in different ways. In healthy cells, the change of DNA transcript can cause cells to become cancerous.

Dt. Basu AK, at the University of Connecticut, in the study of "DNA Damage, Mutagenesis and Cancer" said, "Generation of DNA damage (also known as DNA adducts or lesions) induced by these agents is an important first step in the process of carcinogenesis".
In cancers cells, the change of DNA may prevent proliferation via induction of cancer death.

Dr. Apostolos G. Klinakis, lead scientist in the study of "Genome-wide insertional mutagenesis in human cells by the Drosophila mobile element Minos", wrote," By simple transfections of plasmid Minos vectors in HeLa cells, we have achieved high-frequency generation of cell lines, each containing one or more stable chromosomal integrations".

The process in the change of DNA of the healthy human cell is a highly complex, depending on types of the gene have been alternated, for examples damaged DNA replication gene may lead to gene mutations, which in turn may give rise to altered proteins. and mutations in a tumor-suppressor gene or a gene that controls the cell cycle can generate a clonal cell population with a distinct advantage in proliferation.

Such a mutation process can be divided into the stages of initiation, promotion, and progression, which may occur over a long period of time. Therefore, for a healthy cell to become cancerous, every step in the process must be executed with no mistake. In other words, long-term exposure to a carcinogen can lead to the induction of human cancer.
Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.

The herbal medicine has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

In the investigate whether Foeniculum vulgare (fennel) essential oil (FEO) process a potency against genotoxicity induced by cyclophosphamide (CP), researchers at the Ganpat University, launched a study to examine the result from in mice.

The mice bone marrow chromosomal aberration (CA), micronucleus, and sperm abnormality assays were employed to measure genotoxicity and cytotoxicity in the entire experiment.

Mice used in the testing were administered two different doses of FEO (1 and 2 mL/kg) continuously for 3 days at intervals of 24 hours by the oral route before tissue sampling.

At the and of the study, researchers found that before administration of fennel essential oil, cyclophosphamide (CP) causes a significant increase in the average percentage of aberrant metaphases and induces cytotoxicity in mouse bone marrow cells, and abnormal sperms in the male germ line.

The application of CP also decreased the levels of antioxidants produced by the mice tissue such as
superoxide dismutase (SOD), glutathione (GSH), catalase (CAT) and increased levels of malondialdehyde (MDA).

These result suggested that CP induces a significant oxidative stress by causing an imbalance of the ratio of antioxidants and free radicals in the body of tested subjects.

Mice group pretreatment with FEO exerts a significantly inhibited against the induction of CP, including the frequencies of aberrant metaphases, CAs, micronuclei formation, and cytotoxicity in mouse bone marrow cells.

Furthermore, application of fennel essential oils also reduced the production of abnormal sperm and improved the antioxidants enzymes SOD, CAT, and GSH activities and inhibited oxidative stress observed by decreasing MDA content in the liver.

Dr. Tripathi P, the lead author, after taking into account co and confounders said, "FEO inhibits genotoxicity and oxidative stress induced by CP.

Additionally, in the comparison to examine the effect of plant peptides of thionine Ns-W2 extracted from seeds of fennel flower (Nigella sativa) and β-purothionine from wheat germs (Triticum kiharae), as well as a synthetic antimutagen (crown-compound), on the expression of several genes involved in the.control of cellular homeostasis, processes of carcinogenesis, and radiation response in human rhabdomyosarcoma cells (RD cells), researchers found that all of these agents acted as antimutagens-anticarcinogens, reducing the expression of genes involved in carcinogenesis through some complex pathways involving cellular proliferation, anti-apoptosis, cellular survival in tumor cells.

In compared to other agents, thionine Ns-W2 exerts the most pronounced reduction in the mRNA level of these genes.

Taken all together, fennel may be considered a chemotherapeutic functional food in the protection of our body against mutagenesis, the process that can lead to the onset of cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Investigation of antimutagenic potential of Foeniculum vulgare essential oil on cyclophosphamide induced genotoxicity and oxidative stress in mice by Tripathi P1, Tripathi R, Patel RK, Pancholi SS.(PubMed)
(2) [Comparative analysis of natural and synthetic antimutagens as regulators of gene expression in human cells under exposure to ionizing radiation].[Article in Russian] by Mikhailov VF, Shishkina AA, Vasilyeva IM, Shulenina LV, Raeva NF, Rogozhin EA, Startsev MI, Zasukhina GD, Gromov SP, Alfimov MV. (PubMed)

Carrots, the Veggie Which Normalizes Levels of Blood Glucose in Patient with Hyperglycemia

Kyle J. Norton

Carrots may have a profound and positive effect in normalizing the levels of sugar in the blood, some scientists suggested.

 Hyperglycemia is a condition characterized abnormal high levels of plasma glucose circulated in the blood.

The syndrome does not cause any symptom until the levels of sugar are elevated above 180 to 200 milligrams per deciliter (mg/dL), or 10 to 11 millimoles per liter (mmol/L).

Hyperglycemia is considered an early culprit for the onset of type 2 diabetes. Untreated managed type 1 and 2 diabetes that causes prolonged periods of high blood glucose may induce some unpredictable complications, such as nerve, kidney, foot, and eye damage.

If you are diabetic and have fasting and after meal fasting glucose of higher than 130 mg/dL and over 140 mg/dL respectively, you are considered to have the onset of hyperglycemia.

The causes of hyperglycemia are associated with numbers of the factor. However, researchers as of today, do not know why people with the same health condition and family history, some are susceptible to the risk of the condition, while others do not.

Some researchers suggested that people who have diabetes skipping or forgetting your insulin or oral glucose-lowering medicine,  eat far more carbohydrates compared to the normal intake of insulin and don't take part in daily exercise are most dangerous to have hyperglycemia.

In compared to hyperglycemia, prediabetes is a condition in which blood sugar levels that are higher than normal but lower than of diabetics.

If you are diabetes, and experiencing symptoms of fruity-smelling breath, persistent gastrointestinal discomforts,  shortness of breath and dry mouth, you have hyperglycemia. Please make sure you check with your doctor to rule out the possibility.

In serious cases, some diabetes with hyperglycemia also experience symptoms of confusion, stomach pain, and coma.

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asian and Europe.

In the study to investigate the relationship between hyperglycemia and both serum carotenoids and intake of vegetables and fruits in a total of 284 subjects, 133 with a history of diabetes mellitus or 151 with hyperglycemia diagnosed using a 5.6% cutoff value for hemoglobin A1c (High HbA1c group, n = 151) from among inhabitants of a rural area in Hokkaido, Japan, match with healthy control researchers found that

* The odds ratio (OR) for high HbA1c was 0.49 (95% confidence interval: 0.29-0.85) on high intake frequency of carrot and pumpkin.

* There are no significant relationships between high HbA1c and intake frequencies of other vegetables and fruits.

These results suggested that carrot and pumpkin have a positive effect in reducing the levels of blood glucose in patients with high HbA1c, compared to the intake of other fruits and vegetables.

Furthermore, in the evaluation of serum carotenoid levels among residents with hyperglycemia who were screened in a health check-up program for the inhabitants living in a rural area of Hokkaido compared with those with normal levels, researchers showed that 

* Serum levels of alpha, beta-carotenes, and cryptoxanthin were lower among those with high HbA1c newly detected than among those with a normal level.

* Observation on diabetics who have already been under control in the clinic, showed no significant differences of serum levels of carotenoids, or lipids such as total cholesterol and TBARS compared to other groups

 The information indicated that serum carotenoid levels can be used as an indicator of food intake and oxidative stress for the prediabetic condition since newly detected hyperglycemia tends to show lower serum antioxidant levels such as beta-carotene, and higher serum lipid peroxide levels.

Interestingly, researchers after taking other factors into account said, " males who currently smoked and drank alcohol, the intake frequency of carrot or pumpkin was significantly lower for those with high HbA1c than for the others".

Taken all together, people who have diabetes and are at higher risk may want to add a portion of carrot into their daily diet for preventive measure.

Since the studies quoted in this articles are observational bases, therefore, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of carrot's anti-hyperglycemic possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Relationship between serum carotenoids and hyperglycemia: a population-based cross-sectional study by Suzuki K1, Ito Y, Nakamura S, Ochiai J, Aoki K.(PubMed)
(2) [A study on serum carotenoid levels of people with hyperglycemia who were screened among residents living in a rural area of Hokkaido, Japan].
[Article in Japanese] by Suzuki K1, Ito Y, Otani M, Suzuki S, Aoki K(PubMed)

Green Tea, the Beverage May Speeds Up the Healing of Chronic Back Pain

By Kyle J. Norton, Master of Nutrition

Green tea may have a therapeutic and positive effect in ameliorated symptoms and treatment of chronic back pain, some scientists suggested.

Chronic back pain is a condition of musculoskeletal disorders(MSDs) of the spine that lasts more than 3 months, caused by various factors, including bone fractures, muscle or ligament injury, arthritis, herniated discs. aging,...

Certain symptoms are associated with patients with chronic back pain, including loss of bowel or bladder control if the condition is on the lower back,  numbness, tingling, or weakness in one or both legs and constant pain that gets worse at night.

According to the statistic provided by the Australian Institute of Health and Welfare,

* In 2014–15, an estimated 3.7 million Australians (16%, or 1 in 6 people) had chronic back problems.

* The prevalence of the condition increases with age up to before declining slightly in aged 75 and over.

*More than three-quarters (77%) of people with chronic back problems were of working age (15–64), and

* In 2008–09, around 1.8% of total health-care expenditure in Australia ($1.2 billion) was attributed to back problems, causing a significant burden to the economy in the country.

Some researchers in the finding of mutated genes which have strong influence in the onset of chronic back pain suggested, " ...only a minority of the genetic influences was caused by genes affecting disc degeneration suggesting that genes involved in pain perception, signaling, and psychological processing (Foulkes and Wood 2008), and genetic variants of immune genes (Solovieva et al. 2004b) contribute to the proportion of heritability of chronic back pain".

These results indicated that genetic mutation inherited from the parent may have a minor effect in contributing to the early development of the condition.

Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.

Application of biologically active polyphenol epigallocatechin 3-gallate (EGCG) demonstrated a significant effect in reduced back pain through facilitating the anti-inflammatory and anti-catabolic activity in patients with intervertebral disc (IVD) disease due to age-related changes in the adult disc in the induction of back pain.

According to the study by the Institute for Biomechanics (D-HEST), ETH Zurich ingestion of green tea EGCG on back pain patients, human IVD cells isolated from patients undergoing surgery due to degenerative disc disease (n = 34) and cultured in 2D or 3D indicated that the phytochemical inhibited levels of inflammatory response activated by IL-1β, a cytokine protein produced by macrophages, with function in contributing the inflammatory pain hypersensitivity in the site of infection observed by the reverse transcription polymerase chain reaction (qRT-PCR), western blotting, enzyme-linked immunosorbent assay (ELISA), immunofluorescence and transcription factor assay.

Furthermore, the application also displayed a strong effect on reducing expression of
p38 mitogen-activated protein kinases in mediated inflammatory factors of IL-1β in responded to stress stimuli.

Also, according to the Institute for Biomechanics (D-HEST), in the investigation of the analgesic properties of EGCG, by the von Frey filament test in Sprague-Dawley rats (n = 60), green tea EGCG injection also significantly inhibited the expression of pro-inflammatory mediators as expressed in above and reduced matrix metalloproteinases which have been found to associate to pro-inflammatory cytokines, chemokines and other proteins to regulate varied aspects of inflammation and immunity.

Moreover, in the radiculopathy pain component, researchers also indicated that EGCG inhibited the inflammation in the precipitated back pain through modulating the activity of IRAK-1 in glucose metabolism and insulin sensitivity in skeletal muscle and p38, c-Jun N-terminal kinases (JNK) and nuclear factor NF-κB in response to stress stimuli.

Some researchers indicated that back pain may also be induced by muscle degeneration and impairment nerve injury, leading to increased levels of reactive oxygen species in the induction of tissue apoptosis.

In crushing of the sciatic nerve induced back pain in a tested animal, application of green tea EGCG improved motor function in the toe spread and foot positioning and gained in the percentage motor deficit.

More importantly, EGCG expressed a significant effect in the recovery of sensory innervation in neuropathic pain-like syndrome and improved muscle tissues from injured limb with severe histopathological alterations at the end of week 3 post-surgery in treated animals.


According to the RT-PCR assay, EGCG treatment also normalized the Bax/Bcl-2 ratio, the abnormal ratio of the Bax/Bcl-2 ratio has been found to associate with the induction of nerve cell apoptosis as well as inhibiting levels of p53 with function in regulated the cell death cycle at days 3 and 7 post-surgery.

These results demonstrated an important effect of green tea EGCG in the enhanced functional recovery, by protecting muscle fibers from cellular death, and improving morphological recovery in the skeletal muscle after nerve injuries.

However, in the study of caffeine activity in the modulation of pain perception in chronic pain states of 131 patients with chronic low back pain (64 men and 67 women; mean age = 42.1 years; mean duration of pain = 6.1 years) referred to a multidisciplinary pain clinic over a 2-year period, researchers found that caffeine is not related to the global experience of pain and disability in patients with chronic low back pain, although high caffeine use may be embedded in the context of other unhealthy lifestyle behaviors.

Taken all together, green tea and its bioactive component epigallocatechin 3-gallate (EGCG) may be considered functional foods in reduced back pain caused by physical damage of the spine and injured nerve cells.

Intake of green tea supplement should be taken with exceptional care as some cases of liver acute toxicity have been reported in medical literature.


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Ovarian Cysts And PCOS Elimination
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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epigallocatechin 3-gallate suppresses interleukin-1β-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats by Krupkova O1, Sekiguchi M, Klasen J, Hausmann O, Konno S, Ferguson SJ, Wuertz-Kozak K.(PubMed)
(2) (-)-Epigallocatechin-3-gallate (EGCG) attenuates functional deficits and morphological alterations by diminishing apoptotic gene overexpression in skeletal muscles after sciatic nerve crush injury by Renno WM1, Al-Maghrebi M, Al-Banaw A.(PubMed)
(3) Caffeine and chronic low back pain by Currie SR1, Wilson KG, Gauthier ST. (PubMed)
(4) Genetic Factors Modulating Chronic Back Pain by Julia Metzner and Irmgard Tegeder

Green Tea, the Beverage Which Inhibits Airway Inflammatory Diseases

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced risk airway inflammation and treatment of arthritis, some scientists suggested.

Inflammation is a physical condition characterized by reddened, swollen, hot, and often painful of one and some parts of the body, due to the immune response to injury or infection.

In other words, inflammation is a result of the immune response by the macrophages, activating the proinflammatory cytokines protein in protecting the damage and injured tissue against foreign pathogens invasion in the acute phase of infection.

Some cytokines with duo function in switching from anti-inflammatory cytokines against inflammation under normal condition to proinflammatory in the acute phase of body damage and injury.

Although the activation of proinflammatory cytokines plays an important role in healing the body injured tissue, overproduction can cause abnormal healing with scars and death of healthy cells.

For example, Overproduction of inflammatory cytokines in hepatitis infection can cause liver scars, leading to the development of liver fibroid.

According to the statistic provided by the AMERICAN GASTROENTEROLOGICAL ASSOCIATION, more than 30 million people take over-the-counter and prescription NSAIDs for pain relief, headaches, and arthritis every day, including 20 NSAIDs available by prescription only.

Anti-inflammatory pain and fever reliever drugs such as aspirin, ibuprofen, or Celebrex may be effective, however, they can induce certain side effects, including gastrointestinal discomforts, such as heartburn, .headaches,. and dizziness.

In serious cases, nonsteroidal anti-inflammatory drugs can induce kidney damage, stomach ulcer, and high blood pressure.

If you are currently taking the medicine, please make you know all the side effects. Longterm use of the medicine can also increase the risk of bleeding and damage to the small intestine.

Green tea is a precious drink processed numbers of health benefit known to almost everyone in Asia and the Western world.

In the investigation of green tea, bioactive polyphenols epigallocatechin 3-gallate (EGCG) in the reduced risk airway inflammation through its immune modulatory activities in several cytokines and pathways researchers at the College of Medicine found that application of EGCG exerts a significant impact in regulating the breakdown of extracellular matrix in normal physiological processes of matrix metalloproteinase (MMP-9) with function in remodeling the major change that is responsible for irreversible asthmatic airflow restriction in toluene diisocyanate (TDI)-inhalation lung tissues associated in the initiation of pulmonary diseases.

Further analysis also suggested that EGCG reduces airway inflammation through inhibiting overproduction of the levels of TNF-alpha and Th2 cytokine (IL-5) in BAL fluid during the course of the systemic inflammatory response against the invasion of bacteria and virus in acute phase reaction.

These results indicated that EGCG processes a strong impact in reduced airway constriction caused by inflammatory agents in facilitating the asthmatic reaction.

Interestingly, the efficacy of EGCG decreased airway inflammation induced by application of T DI through its antioxidant activity and stimulated the production of natural antioxidants in the body tissue by preventing the ROS in the precipitated chain reaction to induced cytotoxicity and suppressed MMP-9 in orchestrated inflammatory cell migration.

Dr. Kim SH, after taking account of other co-founders, said, "Epigallocatechin-3-gallate (EGCG), a major form of tea catechin, has anti-allergic properties" and " EGCG regulates inflammatory cell migration possibly by suppressing MMP-9 production and ROS generation".

The above differentiation was supported by the study of biological activity of EGCG in anti-allergic and anti-inflammatory activities of lung tissues in an asthma model-mouse, and nasal epithelial cells of patients with allergic rhinitis conducted by the.

According to the evaluation, compared to control group, treatment group ameliorated the expression of MUC5B with physiologic functions in the mucus gel that ensure normal mucus clearance and p38 mitogen-activated protein kinase (MAPK) in response to stress stimuli such as inflammatory factors in the induction of cell differentiation, apoptosis and autophagy to protect the body against infectious cells to growth and site expansion.

Similarly, application of green EGCG also reduced expression of MMP-9 in enhancing inflammatory cell migration as found in the first study without alternating the extracellular signal-related kinase (ERK)1/2 MAPK expression in response to inflammatory factors.

These results suggested that EGCG demonstrated a potential effect in reducing airway inflammation through interaction with the nasal epithelial cells of patients with allergic inflammation by decreased phorbol 12-myristate 13-acetate (PMA)-induced MUC5B and MMP-9 expression.

According to the experiment of murine heterotopic tracheal allograft model of OB in mice model, injection of green tea EGCG inhibited inflammation, with significantly less neutrophil and macrophage infiltration and significantly reduced fibrosis. Those factors were found to contribute to the rejection of the transplant lung organ.

Moreover, EGCG also decreased expression of inflammatory cytokines production involved systematic inflammation and protein monocyte chemokine monocyte chemoattractant protein-1 (MCP-1) in promoting infectious cells migration and infiltration of monocytes/macrophages through increased antifibrotic cytokine interferon-γ-inducible protein-10 (IP-10) and decreased profibrotic cytokine transforming growth factor-β (TGF-β) information of excess fibrous connective tissue in the organ or tissue.

The findings strongly suggested that EGCG has great potential in ameliorating the development of obliterative airway disease.

Taken all together, green tea containing bioactive polyphenols EGCG may be considered a functional food in the prevention of airway inflammation and airway-related diseases through a complex system involved may proteins and pathways.

However, the intake of green tea supplement should be taken with exceptional care, as acute liver toxicity has been reported in some medical literature.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Green tea epigallo-catechin-galleate ameliorates the development of obliterative airway disease by Liang OD1, Kleibrink BE, Schuette-Nuetgen K, Khatwa UU, Mfarrej B, Subramaniam M.(PubMed)
(2) The effect of Epigallocatechin-3-gallate in allergic airway inflammation by Choi YS, Bae CH, Song SY, Kim YD. (PubMed)
(3) Epigallocatechin-3-gallate protects toluene diisocyanate-induced airway inflammation in a murine model of asthma by Kim SH1, Park HJ, Lee CM, Choi IW, Moon DO, Roh HJ, Lee HK, Park YM(PubMed)