Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Friday, 5 October 2018

Herbal Arnica, The Functional Herb Which Stops the Onset of Chronic Diseases Associated with Oxidative Stress, Researchers Found

Arnica may have a profound and therapeutic effect in reducing the risk of diseases associated with overexpression oxidative stress, some scientist suggested.

The expression of oxidative stress is a medical condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissue.

In some cases, this reaction also is caused long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.

Dr. Ercal N, the lead author in the study of the relation of toxic metals and oxidative stress, wrote, "antioxidants may play an important role in abating some hazards of heavy metals. In order to prove the importance of using antioxidants in heavy metal poisoning, pertinent biochemical mechanisms for metal-induced oxidative stress".

There is no single cause of oxidative stress. Some researchers suggested that numbers of factors can facilitate the onset of oxidative stress, including cigarette smoke, oxidative burst from activated macrophages, particularly, the free radicals chain reaction.

Sadly, a prolonged period of oxidative stress presented in the human body can cause oxidative damage to biomolecules, (lipids, proteins, DNA) and death of healthy cells through cytotoxicity.

Certain chronic diseases are found to be associated with oxidative stress, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.

By changing diet and lifestyle, oxidative stress can be managed or avoided, Dr. Seungyoun Jung, the lead author in the study of Healthy Dietary Patterns and Oxidative Stress suggested, "Healthy diets may lower oxidative stress and risk of chronic diseases" and "Among specific food groups that contribute to these diet scores, significantly positive associations were observed with legumes and vegetables for FlOP_360, vegetables and fruits for FlOP_320, and legumes and alcohol for FlOP_400".

Where fluorescent oxidation products (FlOP) is a global marker of oxidative stress

Arnica is a herbaceous species, genus perennial, belonging to the family Asteraceae, native to Europe and Asia.

The Herbal medicine used in herbal medicine for centuries to treat strains, sprains, and bruises.

The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivatives.

In the analysis of the effect of Arnica Arnica on mitochondrial oxidative stress induced by Ca(2+) plus inorganic phosphate and/or Fe(2+)-citrate-mediated lipid peroxidation through changes in oxygen consumption rates in adult male Wistar rat, researchers found that application of Arnica at dose of 6cH, 12cH, 30cH or succussed 30% ethanol (control) for 21 days, exert a strong activity in reduced expression of lipid peroxidation of mitochondrial membranes through inhibiting the antimycin-A, a toxic chemical with function in initiated production of free radicals.

Under oxidative stress conditions caused by injection of Ca(2+) and inorganic phosphate, tested group with a dose of Arnica 30cH demonstrated the effect in decreasing mitochondrial O(2), an indication of lesser expression of free radicals presented in the mitochondrion, through the herbal antioxidant activity.

In liver tissues, administration of Anise at dose 30cH in the tested group also protected the hepatic mitochondrial membrane permeabilization by inhibited ROS on the induction of lipid peroxidation and precipitated fragmentation of proteins.

Further evaluation of the study showed that these results of free radical inhibitory effect were attributed to levels of antioxidant from the herb and the herb in the stimulated production of antioxidants of the tested host.

Additionally, in the investigate the therapeutic effects and mechanism of action of A. Montana flower methanol extract (AMME) against both inflammation and oxidative stress in a collagen-induced arthritis (CIA) rat model, scientists suggested that oral administration of AMME reduces clinical signs and improves the histological and radiological status of the hind limb joints, through reducing overexpression of levels of nitric oxide, tumor necrosis factor-α, interleukins (IL-1β, IL-6 and IL-12) and titer of anti-type II collagen antibody activated by high levels of oxidative stress.

This inhibitory effect of AMME against overproduction inflammatory factors not only reverses the disturbed antioxidant levels and peroxidative damage but also inhibits the overproduction of inflammatory cytokines in facilitated cell damage and healthy cell death at the site of infection.

Moreover, according to the gas chromatography/mass spectrometry (GC/MS) analysis, the function of Arnica in the alleviation of arthritis by ameliorating ROS expression was attributed to the combined action of phenolic and flavonoid compounds.

Dr. Sharma S, the lead author said, " The study also shed some light on mechanisms involved in the diminution of inflammatory mediators and free radical-generating toxicants and enhancement of the antioxidant armory, thereby preventing further tissue damage, injury and synovial hyperproliferation in arthritis".

The above differentiation was supported by the National Institute of Research and Development for Biological Sciences study of A. montana and A. absinthium ethanolic extracts antioxidant activity and protective effect against H2O2-induced oxidative stress in a mouse fibroblast-like NCTC cell line.

According to the final assessment, researchers suggested that both A. absinthium and A. montana extract showed a strong antioxidant capacity but lesser in A. montana, compared to A. absinthium.

At the doses of the range of 10-100 mg/L and A. montana and 10-500 mg/L A. absinthium, both extracts exhibited a significant oxygen radical absorbance capacity and 2,2-diphenyl-1-picrylhydrazyl free radical-scavenging activity and protected fibroblast cells against hydrogen peroxide-induced oxidative damage, depending on the levels of flavonoids and phenolic acids contents presented in the extracts.

According to the neutral red and lactate dehydrogenase assays, pretreatment with 10 mg/L A. montana and 10-300 mg/L A. absinthium was considered the best protection against the early onset of ROS production in H2O2-induced oxidative stress in a mouse fibroblast-like NCTC cell line.

Importantly, pre-treatment with A. montana and A. absinthium extracts also restored the proportion of cells in each phase of the cell cycle through inhibiting oxidative stress in the induction of cytotoxicity.

Taken together, Arnica and its bioactive chemical may be considered a functional food in reduced inflammatory-related diseases caused by overexpression of oxidative stress. However, intake of Arnica supplement should be taken with extreme care for the prevention of acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of the oral administration homeopathic Arnica montana on mitochondrial oxidative stress by de Camargo RA1, da Costa ED, Catisti R.(PubMed)
(2) Cumulative therapeutic effects of phytochemicals in Arnica montana flower extract alleviated collagen-induced arthritis: inhibition of both pro-inflammatory mediators and oxidative stress by Sharma S1, Arif M1, Nirala RK1, Gupta R2, Thakur SC(PubMed)
(3) Evaluation of antioxidant and cytoprotective activities of Arnica montana L. and Artemisia absinthium L. ethanolic extracts by Craciunescu O1, Constantin D, Gaspar A, Toma L, Utoiu E, Moldovan L.(PubMed)
(4) Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage by Ercal N1, Gurer-Orhan H, Aykin-Burns N.(PubMed)
(5) Healthy Dietary Patterns and Oxidative Stress as Measured by Fluorescent Oxidation Products in Nurses’ Health Study by Seungyoun Jung,1,2,3,* Stephanie A. Smith-Warner,1,2 Walter C. Willett,1,2,4 Molin Wang,2Tianying Wu,5 Majken Jensen,2,4 Susan E. Hankinson,4,6 and A. Heather Eliassen. (PMC)

Yoga Therapy In the Prevention and Treatment of Chronic Inflammatory Diseases

By Kyle J. Norton (Master of Nutrients, All right reserved)

Yoga therapy may have a strong impact in reducing the risk of inflammation by significantly decreased expression of pro-inflammatory cytokines, a US university study suggested.

Inflammation is a natural response of the immune system in the stimulation of the production of inflammatory cytokines with an aim to protect our body against infectious agents in the acute phase of bodily injury and tissue damage.

However, in many instances, overexpression of pro-inflammatory cytokines can cause cells death and tissue damage, leading to irreversible organs damage with large scars formation.

For example, overexpression of pro-inflammatory cytokines in the healing of hepatitis virus infection can lead to liver scars.

Furthermore, inflammation that lasts more than 3 months may be considered chronic inflammation, a leading cause of chronic diseases.

Chronic inflammation occurs when the immune system no longer has the ability to kill off all the infectious agents, during the onset of acute infection.

Moreover, chronic inflammation also happens in people with the autoimmune disorder. In this case, the immune system attacks the bodily normal healthy tissue, by mistaking them for foreign pathogens that cause disease.

Yoga, the ancient technique for harmonized external and internal body well being, through breath control, meditation, bodily movement, and gesture.....

The practice has been well known for people in the Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In a randomized controlled 3-month trial conducted with two post-treatment assessments of 200 breast cancer survivors assigned to either 12 weeks of 90-minute twice per week hatha yoga classes or a wait-list control researchers at The Ohio State University showed that
* Yoga demonstrated significantly reduced proteins in the production of pro-inflammatory expression, namely IL-6, TNF-α, and IL-1β in compared to the control group.

* Inflammation induced lower levels of energy also reduced such as fatigue and improved vitality after 3 months of engagement but not at the beginning of the class.

Dr. Kiecolt-Glaser JK, the led author said, "Chronic inflammation may fuel declines in physical function leading to frailty and disability. If yoga dampens or limits both fatigue and inflammation".

Truly, yoga practice calms the central nervous system against the onset of psychological stress which in turn, decrease the production of stress hormones in compromising the immune system.

Yoga practice has a direct impact on the calming of the nervous system in turn, improves the immune system in the correct differentiation of its response against foreign pathogens. thus, reducing the risk of autoimmune disease and overproduction of inflammatory cytokines in initiating chronic inflammatory diseases.

Other researchers in the concerns of global obesity prevalence and overexpression of tissue and circulating inflammatory biomolecules in these group of the population may cause vascular inflammation and atherogenesis, and subsequently, cardiovascular disease developing postulated that yoga-based lifestyle intervention may be used as a promising option,
* In reducing the weight of obesity that decreases the risk of onset of inflammatory diseases.

* In reducing the risk of chronic diseases as inflammation may be prevented and managed through a change of lifestyle

The study also emphasized that yoga therapy is simple to follow and cost-effective with high compliance. therefore, it may be recommended as a secondary treatment combined with the standard application.

Furthermore, Dr. Sarvottam K, the led author said, "The efficacy of such lifestyle intervention programmes is multifaceted and is achieved via a reduction in weight, obesity-related inflammation on and stress, thereby culminating into risk reduction towards several chronic diseases including CVD".

By bringing back the presence and dealing it in a positive way, long-term yoga participants may choose to improve immune function through the change of diet and lifestyle to combat chronic inflammatory diseases.

More interestingly, in a proposed study of 16 breast cancer survivors with persistent cancer-related fatigue randomized to a 12-week Iyengar yoga intervention (n=16) or a 12-week health education control condition (n=15), researchers indicated that
* Yoga treatment group expressed a reduced production of pro-inflammatory transcription including, nuclear factor kappa B (NF-κB), and increased activity of the anti-inflammatory cytokines such as glucocorticoid receptor.... compared to control.

* All inflammatory markers, such as soluble tumor necrosis factor receptor type II (sTNF-RII) were lower in yoga therapy group compared to the increase in the educational group.

Dr. Bower JE the led author opinionated, Yoga participated improved the lower level of energy caused by inflammation-related gene expression in breast cancer survivors with persistent probably through enhancing behavioral and physical health after 12 weeks.

Taking all together, Yoga may be considered as an integrated form of exercise in reduced risk and treatment of inflammation-inducing poor behavioral and physical activities.

Sources
(1) Yoga's impact on inflammation, mood, and fatigue in breast cancer survivors: a randomized controlled trial by Kiecolt-Glaser JK1, Bennett JM, Andridge R, Peng J, Shapiro CL, Malarkey WB, Emery CF, Layman R, Mrozek EE, Glaser R.(PubMed)
(2) Obesity-related inflammation & cardiovascular disease: efficacy of a yoga-based lifestyle intervention by Sarvottam K, Yadav RK1.(PubMed)
(3) Yoga reduces inflammatory signaling in fatigued breast cancer survivors: a randomized controlled trial by Bower JE1, Greendale G2, Crosswell AD3, Garet D4, Sternlieb B5, Ganz PA6, Irwin MR7, Olmstead R8, Arevalo J9, Cole SW10. (PubMed)

Green Tea and Its' Polyphenols (GTPs) That Protect Our Bodily Skin Against the Onset of Cancer, Scientists Say

By Kyle J. Norton, Master of Nutrition

Green tea may have a strong and positive effect in reduced risk and treatment of skin cancer, some scientists suggested.

Skin cancer is a medical condition characterized by irregular cell growth in the issues of skin.

At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.

According to statistic, approximately, 87,110 new cases of invasive melanoma are diagnosed in the U.S every year.

The exact causes of skin cancer are unknown. Researchers believed that there are a set of factors that can have the substantial effect to initiate the onset of skin cancer.

Truly, according to the studies, people who have fair skin, regardless of skin color, a history of sunburns, excessive sun exposure, including occupations which are required to work outside during Summar months, moles, family history of skin cancer. and previous and personal history of skin cancer is at the increased risk of skin cancer or recurrence of skin cancer.

The American Institute for Cancer Research, certain lifestyle habits can increase the risk of skin cancer, such as drinking too much coffee, excessive alcohol drinking and long-term intake of certain medications in suppressing the immune system.

Green tea a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.

The evaluation of green tea effect in overexposure to environmental solar ultraviolet (UV) radiation (290-400 nm) which has been found to increase risk of the development of melanoma and non-melanoma skin cancers in mice model showed that oral administration of green tea polyphenols (GTPs) in drinking water or the topical application of EGCG prevents UVB-induced skin tumor development in tested subjects.

Particularly, (-)-Epigallocatechin-3-gallate (EGCG), the major and most photoprotective polyphenolic component of green tea also exhibited a protective activity against UV in induction of skin cancer, through induction of immunoregulatory cytokine interleukin (IL) 12 in differentiation of naive T cells into Th1 cells and acted as T cell-stimulating factor in stimulate the growth and function of T cells.

Moreover, interleukin (IL) 12 also demonstrated a significant effect as an antagonist against immunosuppression induced by solar/ultraviolet (UV) radiation by restoring immune responses and also stimulating DNA repair.

Further analysis also indicated that green tea (-)-Epigallocatechin-3-gallate (EGCG) also inhibited UV in the induction of skin tumors; the angiogenetic effect in the stimulated production of new blood vessels to
provide nutrients and oxygen for cancer cells proliferation and survivals and initiated cytotoxic T lymphocyte cells in induced cancer and infectious and damage cells apoptosis.

Interestingly, additional study of green tea polyphenols (GTPs) in prevention of UVB irradiated (80 mJ/cm(2)) 3 times each week for 24 wk in induced skin cancer in mice divided in to group consumed water and group fed with water containing 2 g/L GTPs, showed that group treated with GTPs displayed a significantly reduced UVB-induced tumor incidence by 35%, tumor multiplicity by 63%, and tumor growth by 55% in compared to non treatment group.

Group treated with GTPs+UVB also demonstrated a reduced expression of the matrix metalloproteinases (MMP)-2 and MMP-9, which are activator associated with progression from benign to advanced cancer and enhanced expression of specific endogenous tissue inhibitors of metalloproteinases (TIMPs), tissues inhibitor of MMP in skin tumors in compared to mice treated with UVB alone.

Furthermore, GTPs+UVB group also reduced expressions of CD31 and vascular endothelial growth factor, inactivated development of new blood vessel to nourish skin tumor cells proliferation and site expansion and inhibited expression of proliferating cell nuclear antigen, a key factor in DNA replication and cell cycle regulation in skin cancer in compared to UVB group.

More importantly, mice treated with GTPs+UVB group also showed more cytotoxic CD8(+) T cells in the tumors in compared to UVB group by exhibited greater activation of caspase-3 expression in induced apoptosis of the tumor cells.

The information findings suggested a potential and therapeutic effect of green tea and its bioactive polyphenols (GTPs) in attenuated risk, progression, and treatment of melanoma and non-melanoma skin cancers.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green Tea Prevents Skin Cancer by Two Mechanisms by Navid Bouzari, Yvonne Romagosa, Robert S. Kirsner(PubMed)
(2) Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair by Katiyar S1, Elmets CA, Katiyar SK. (PubMed)
(3) Orally administered green tea polyphenols prevent ultraviolet radiation-induced skin cancer in mice through activation of cytotoxic T cells and inhibition of angiogenesis in tumors by Mantena SK1, Meeran SM, Elmets CA, Katiyar SK. (PubMed)

Fennel, The Herbal Remedy Which Protects Our Body Against The Onset of Acute Inflammation and Chronic Inflammatory Diseases, Scientists Find

Kyle J. Norton

Fennel may process a strong anti-inflammatory activity in reducing the risk of tissue injury and cell apoptosis, some scientists suggested.

Acute inflammation is a natural and systematic immune response to protect our body against invasion of foreign bacteria and virus by the initiated production of inflammatory cytokines to the site of infection.

However, overproduction of pro-inflammatory cytokines initiated by the immune system for a prolonged period of time may lead to cells damage and sometimes death of the healthy cells in the infectious site and nearby cells.

These complications can also cause improper healing for the forming of scars and damage to the tissue of the organ, affecting and limiting the organs functioning, such as liver scars caused by hepatitis virus infection.

Badly enough, some proteins process the duo functions of pro and anti-inflammation. Under abnormal conditions, they can switch from their original action of anti-inflammatory cytokines to pro-inflammatory cytokines.

Furthermore, chronic inflammation occurred that lasts for months or years when the immune system response to the site of infection failure to eliminate agents that cause acute inflammation.

An autoimmune disorder that attacks normal healthy tissue, mistaking them for pathogens that can also cause chronic inflammatory disease.
Most cases of inflammation, are treated with NSAID's, or non-steroidal anti-inflammatory drugs. However, in some people intake of these medications can cause common and serious side effects, including gastrointestinal issues, such as pain, constipation, diarrhea, gas, nausea, and stomach ulcers, kidney problems, anemia,.... and swelling in the leg.

If you are presently taking anti-inflammatory medicine, please make sure that you discuss the adverse effects with your doctor.

Fennel (Foeniculum vulgare) is a plant species, belongings to Apiaceae (Umbelliferae), native to the Mediterranean.

The herbal medicine has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

According to study of BALB/C mice were intraperitoneally administered anethole (62.5, 125, 250, or 500 mg/kg) 1 h before intratracheal treatment with LPS (1.5 mg/kg) and sacrificed after 4 h, researchers found that in anethole treatment group exerts a significant increase of numbers of mobile white blood cells macrophages and neutrophils, the first immune response to the infectious site.

Furthermore, application of LPS also induced production of inflammatory mediators such as matrix metalloproteinase 9 (MMP-9), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) all systematic inflammatory cytokines in response to cellular damage and tissue injury.

Moreover, LPS also exhibited overproduction of nitric oxide (NO) observed in bronchoalveolar lavage fluid in facilitated cellular cytotoxicity.

In the compared nontreatment group, injection anethole group demonstrated a strong anti-inflammatory effect through decrease activities of proinflammatory factors without affecting the immune activity in protects against infection.

Additional analysis also found that treatment group reduced acute lung injury caused by injection LPS through its antioxidants and induced production of host natural antioxidant in the body tissue.

The inhibited LPS results according to were attributed to anethole effect in suppressed the activation of NF-κB in signaling production of inflammatory cytokines by blocking the initiation of IκB-α degradation by inhibited TRAF2 in the induction of inflammation through TNF receptor superfamily members and NIK, a key signaling molecule of the noncanonical NF-κB.

Interestingly, further investigation of anethole as an inhibitor of TNF-induced NF-kB activation (an early response) as monitored by electrophoretic mobility shift assay, by suppression of IkBa phosphorylation and NF-kB reporter gene, researchers also indicated that

* Anethole also suppressed TNF-induced activation of the transcription factor AP-1 in regulated gene expression in response to a variety of stimuli, including LPS application.

*c-Jun N-terminal kinases (JNKs) with function in response to stress stimuli, such as cytokines,
And

* MAPKkinase in signal inflammatory response through transmitting information from a receptor on the surface of the cell to the DNA in the nucleus of the cell.

* Application of anethole also suppressed TNF-induced both lipid peroxidation and ROS generation, through the stimulated production of natural antioxidant in the host and itself, resulting in balancing the ratio of antioxidant and ROS expression.

The illustration and differentiation were elite by the experiment in the application of TNF (100 pM) with the cells pretreated for 240 and 120 min with anethole, NF-kB activation was almost completely inhibited.

However, the inhibition decreased gradually with decreased pre-incubation time.

Taken together, fennel and its bioactive anethole may be considered as a functional food in reduced risk and treatment in acute and chronic inflammatory related-diseases through the properties like a pro antioxidant and anti-inflammatory agent.

Sources
(1) Anti-inflammatory effects of anethole in lipopolysaccharide-induced acute lung injury in mice
by PurumKanga1Ka YoungKima1Hui SuLeea1Sun SeekMinbGeun HeeSeol(PubMed)

(2) Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: e€ffect on NF-kB, AP-1, JNK, MAPKK and apoptosis by Gagan BN Chainy1,2, Sunil K Manna1,2, Madan M Chaturvedi1 and Bharat B Aggarwal by Oncogene (2000) 19, 2943 ± 2950 ã 2000 Macmillan Publishers Ltd All rights reserved 0950 ± 9232/00 $15.00

Topical Arnica Gel, The Potent Herbal Product Which Alleviates Symptoms and Treatment of Osteoarthritis

By Kyle J. Norton, Master of Nutrition

Herbal Arnica may have a therapeutic potential in ameliorating the symptoms and treatment of osteoarthritis, some scientist suggested.

The results of this investigation were carried out in form of studies by some respectable institutes such as Rheumatology Clinic Sweden, and Valens Clinic for Rheumatism published online medical literature.

Arthritis is a chronic condition characterized by severe inflammatory pain and stiffness of the joints. affecting over 1.3 million Americans and as much as 1% of the worldwide population, according to statistics. The disease induced an average direct cost about $2,800 per patient annually.

Osteoarthritis is a type of degenerative joint disease or “wear and tear” arthritis, affecting the joint commonly.

The exact causes of osteoarthritis are unknown. Researchers do not understand why, people with the same health and risk conditions, some are susceptible to the onset of the disease while others do not.

However, researchers do know that certain risk factors are associated to the early onset of the disease, including age, family history, gender, injured from the past that did not heal properly, such as torn cartilage, dislocated joints, ligament injuries, occupations and overweight.

Some scientists also suggested that mutation of genes involved develop cartilage are also having a strong implication in inducing early onset of the disease.

Dr.Mercedes Fernández-Moreno, the lead authors in the expression of Genetics in Osteoarthritis, wrote, "The genetic bases of this disease do not follow the typical patterns of Mendelian inheritance and probably they are related to alterations in multiple genes. The identification of a high number of candidate genes to confer susceptibility to the development of the osteoarthritis shows the complex nature of this disease".

Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is a process of repairing after the damage of skin, tissues, organs, etc.

The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivatives.

In the randomized, double-blind study to compare the effective of topical preparation of arnica(50 g tincture/100 g, DER 1:20), and ibuprofen (5%) and in 204 patients, to ascertain differences in pain relief and hand function after 21 days' treatment, scientists showed that topical Arnica exerts a similar effect as of ibuprofen (5%) in pain and hand function improvements, or in any secondary endpoints.

There were no differences between the two groups in pain relief and improvement of hand stiffness.

However, compared to 2 groups, researchers found that adverse effects were reported by six patients (6.1%) on ibuprofen and by five patients (4.8%) on arnica.

These result suggested that Arnica topical preparation is compatible with those of ibuprofen for the treatment of patients with osteoarthritis, particularly in the patients with hand's osteoarthritis.

Further analysis of the safety and efficacy of an Arnica montana fresh plant gel, applied twice daily, in 26 men and 53 women with mild to moderate osteoarthritis (OA) of the knee, after 3 and weeks of application, researchers indicated that
* All groups (treatment with 3 and 6 weeks) display a significant improvement of scores on the pain, stiffness, and function subscales.

* The topical application also shows significant reductions at these time points.

* Total scores on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) are decreased substantially in all patients.

* According to the returned questionnaire, 69 patients (87%) rate the tolerability of the topical gel as "good" or "fairly good,"

However, the overall local adverse-event rate is 7.6% included only one allergic reaction.

Although the topical gel may be effective, it has certain limitations as only patients with mild to moderate OA of the knee were included in the study.

The above differentiation of topical Arnica gel was supported by the publication lead by the Dr. Morris M, in the investigation of the efficacy of a homeopathic complex included Arnica montana, Bryonia alba, Causticum, Kalmia latifolia, Rhus Toxicodendron, and Calcarea fluorica. in combination with physiotherapy in treating chronic lower back pain (CLBP) due to OA.

In a 6-wk, randomized, double-blind, placebo-controlled pilot study took place in a private physiotherapy practice in Gauteng, South Africa of a total of 30 males and females, aged 45-75 y, who were receiving physiotherapy treatment for OA of the lumbar spine from a therapist in private practice, according to the observation of the visual analogue scale (VAS) for pain. Secondary outcome measures, complex application showed a incredible effectiveness in reduced pain, promoted daily functioning, and range of motion (ROM) of the lumbar spine in compared to placebo.

After taking into account of other co and confounders, Dr. Morris M, the lead scientist said, "homeopathic complex, together with physiotherapy, can significantly improve symptoms associated with CLBP due to OA" and "(but) the study was too small to be conclusive".

Taken together, topical Arnica gel with certain concentration may be considered a functional herb for alleviated symptoms and treatment of osteoarthritis.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Choosing between NSAID and arnica for topical treatment of hand osteoarthritis in a randomised, double-blind study by Widrig R1, Suter A, Saller R, Melzer J.(PubMed)
(2) Arnica montana gel in osteoarthritis of the knee: an open, multicenter clinical trial by Knuesel O1, Weber M, Suter A.(PubMed)
(3) Physiotherapy and a Homeopathic Complex for Chronic Low-back Pain Due to Osteoarthritis: A Randomized, Controlled Pilot Study by Morris M, Pellow J, Solomon EM, Tsele-Tebakang T.(PubMed)
(4) Genetics in Osteoarthritis by Mercedes Fernández-Moreno, Ignacio Rego, Vanessa Carreira-Garcia, and Francisco J Blanco. (PMC)

Thursday, 4 October 2018

The Cruciferous Vegetables' Phytochemical Indole-3-Carbinol Which Kills Cancer Cells in Vitro, Scientists Suggest

By Kyle J. Norton, Master of Nutrition

Intake of cruciferous vegetables may reduce the risk of cancers, some scientists suggested.

Cancers are a group of chronic and medical diseases characterized by irregular cells growth in the body tissue caused by the change of DNA transcription of healthy cells.

Normal cells have the division of a limited cell cycle compared to a cancerous cell which can grow unlimitedly.

If an invasive tumor is growing too large, it can suppress the nerves and muscles surrounding them, leading persistent pain and other symptoms, depending on the locations.

The exact causes of cancer are unknown. Researchers do not know why people with the same health condition, some are susceptible to the onset of the diseases, while others do not.

However, an unhealthy diet, such as eating processed foods and fast foods and lifestyles such as smoking, overweight, physical inactivity, and excessive alcohol drinking are some of the major causes of cancer.

Truly, according to the article written by the Telegraph, an unhealthy lifestyle is responsible for half of the onset of the cancers. And overweight or obese is a cause of 12 types of cancer.

Other prevalent risk factors of cancer are genetic mutation inherited from the parents, environment toxic chemicals, radiation, virus, hormone imbalance,... and chronic inflammatory diseases.

Besides the general symptoms such as lumps, loss of appetite, fatigue, tiredness, unintended weight loss, patients with cancers also experience some symptoms totally depended to the location, types, and grade of infected tissues and organs,

Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.

According to the recent study, indole-3-carbinol (I3C), a substance presented in cruciferous vegetables suppressed the proliferation of different tumor cells, including those isolated from breast, prostate, endometrium, and colon cancers, in vitro.

Dr. Popolo A, the lead author suggested, the effect of the chemical compound in the treatment of various cancers may be attributed to the interference of cancer cell cycle division and expression of a diverse set of genes involved cell differentiation.

Dr. Aggarwal BB and Dr. Ichikawa H. in the additional examination of the function of indole-3-carbinol (I3C) also found that application of the phytochemical also inhibited DNA-carcinogen abducted and new blood vessels involved cancer cell survival formation, suppressed free-radical production, and stimulated 2-hydroxylation of estradiol in the reduction of cell proliferative and estrogenic activity and

Furthermore, indole-3-carbinol and its derivatives not only exerted the anti-cancer effects through restoring original gene formation but also inhibited free radicals production, ... but also interfered with cancer cell cycle division phase to induce apoptosis.

Other chemical compounds found in the cruciferous vegetables, showed to possess potent antitumor and chemopreventive activity are sulforaphane (SFN), an isothiocyanate and Allyl nitrile (3-butenenitrile).

Taking together, there is no doubt, cruciferous vegetables have exhibited anticancer activities, through many aspects.

Intake of cruciferous vegetables regularly is associated with the reduced risk and treatment of various types of cancer.

However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food of cruciferous vegetables during the course of the disease will be necessary to complete the picture of cruciferous vegetables anti-cancer possibilities.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Two likely targets for the anti-cancer effect of indole derivatives from cruciferous vegetables: PI3K/Akt/mTOR signalling pathway and the aryl hydrocarbon receptor by Popolo A1, Pinto A1, Daglia M2, Nabavi SF3, Farooqi AA4, Rastrelli L5. (PubMed)
(2) Molecular targets and anticancer potential of indole-3-carbinol and its derivatives by Aggarwal BB1, Ichikawa H.(PubMed)
(3) Sulforaphane Induces Cell Death Through G2/M Phase Arrest and Triggers Apoptosis in HCT 116 Human Colon Cancer Cells by Liu KC1, Shih TY1, Kuo CL2, Ma YS3,4, Yang JL2, Wu PP5, Huang YP6, Lai KC7,8, Chung JG9,10. (PubMed)
(4) Allyl nitrile: Toxicity and health effects by Tanii H1.(PubMed)

Carrot, The Veggie Which Normalizes Your High Blood Pressure With No Side Effects, Suggested By MEDLINE Studies

Kyle J. Norton, Master of Nutrition

Carrots may have a profound and positive effect in reduced risk and treatment of hypertension, some scientists suggested.

Hypertension is a common syndrome characterized by abnormally high blood pressure.

High blood pressure (HBP or hypertension) induced narrowing and blocking of blood vessels were associated with increased risk of developing heart failure.

Truly, in hypertensive individuals, the heart must work harder to pump and to circulate the blood to the entire body.

Prolonged and unchecked high blood pressure can increase the force of the blood pushing against the artery walls, leading to a substantial risk of heart attack and stroke.

Usually, high blood pressure has no signs or symptoms, if your blood pressure is persistently high, you must check with your family doctors for preventive pressure.

In some cases, medication may prescribe by your doctor, if your blood pressure is 160/100 or higher.

The exacted causes of high blood pressure are unknown. However, some researchers suggested that unhealthy lifestyle and diet and physical inactivities are the major contributors to the onset of the syndrome.

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

Epidemiological studies strongly suggested that increased fruit and vegetable intake daily and regularly is assowithated to lower blood pressure.

However, according to the searching of the medical literature data bases, most studies were found to engage in short-term intervention.

Therefore, a long term study with a large example size study to reaffirm the possibility is necessary.

In a prospective study to examine the independent association of whole fruit (excluding juices) and vegetable intake, as well as the change in consumption of whole fruits and vegetables, with incident hypertension in 3 large longitudinal cohort studies: Nurses' Health Study (n=62 175), Nurses' Health Study II (n=88 475), and Health Professionals Follow-up Study (n=36 803) conducted by the joint investigation lead by the Brigham and Women's Hospital and Harvard Medical School, researchers found that

* The risk of high blood pressure in compared participants whose consumped ≤4 servings/week, and those whose intake ≥4 servings/day were 0.92 for total whole fruit intake and 0.95 total vegetable intake.

Blood pressure of fruits intake participants displayed a much lower pooled hazard ratios, compared to the same volume of vegetables.

* In compared to participants who did not increase their fruit or vegetable consumption, the pooled hazard ratios for those whose intake increased by ≥7 servings/week were 0.94(0.90-0.97) for total whole fruit intake and 0.98(0.94-1.01) for a total vegetable.

Further differentiation of all fruits and vegetables intake by participants scientist surprisingly found that only consumption levels of ≥4 servings/week, in numbers of specific vegetables were associated with lower hypertension risk in compared to whole fruits.

Dr. Borgi L the lead author, after taking into account of other confounders, said, " greater long-term intake and increased consumption of whole fruits may reduce the risk of developing hypertension".

These results indicated that only daily and regular and increased intake of fruits and certain vegetables may reduce the risk of hypertension in a longer term.

In the investigation of dried purple carrot effect in reduced risk of hypertension in obese individuals, researchers at the The University of Queensland conducted a study containing 16 males (aged 53.1 ± 7.6 years with a mean BMI of 32.8 ± 4.6 kg/m(2)) with normal lipid and inflammatory markers.

Application of 118.5 mg/day of anthocyanins and 259.2 mg/day of phenolic acids for 4 weeks to participants showed an statistically insignificant changes in hypertension.

However, sub-sequenced study with anthocyanins, phenolic acids and carotenoids, the predominant phytochemicals isolated from purple carrots in hypertensive rats induced by a high fat diet, researchers found

* Rat fed with high fat diet developed an elevated hypertension

* Rat fed with a high fat diet with an injection of whole food purple carrot juice showed a significant reduced blood pressure in compared to untreated group.

In compared to isolated phytochemicals researchers suggested that not all bioactive compounds exert a protective effect against the onset of hypertension, it is likely that the anthocyanins are responsible for the antioxidant activity in inhibited excessive reactive oxygen species (ROS) in initiated and exacerbated hypertension.

The findings suggested that whole food carrot may be considered as functional food in reduced risk of hypertension if it is taken daily and regularly over a long term period.

Therefore, people who want to optimize the blood pressure level may want to add some portions of carrot in their diet.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Fruit and Vegetable Consumption and the Incidence of Hypertension in Three Prospective Cohort Studies by Borgi L1, Muraki I2, Satija A2, Willett WC2, Rimm EB2, Forman JP2.(PubMed)
(2) A randomized, double-blind, placebo-controlled trial of the effect of dried purple carrot on body mass, lipids, blood pressure, body composition, and inflammatory markers in overweight and obese adults: the QUENCH trial BY Wright OR1, Netzel GA, Sakzewski AR. (PubMed)
(3) Comparison of purple carrot juice and β-carotene in a high-carbohydrate, high-fat diet-fed rat model of the metabolic syndrome by Poudyal H1, Panchal S, Brown L.(PubMed)
(4) Natural Antioxidants and Hypertension: Promise and Challenges by Tinoy J. Kizhakekuttu, MD and Michael E. Widlansky, MD, MPH (PMC)