Alfalfa, The Functional Herb Which Protects Our Body Against Type 2 Diabetes, Researchers Reveal

By Kyle J. Norton, Master of Nutrition

Scientists may have found a whole herb which processes anti-diabetes property, some scientists suggested.

Diabetes is a chronic condition characterized by insufficient insulin entering the bloodstream to regulate the glucose as a result of either cell in pancreas dying off or receptor sites clogged up by fat and cholesterol.

In some cases, diabetes may also be caused by allergic reactions of cells in the immune system.

The actual causes of diabetes inflammatory condition are debatable.

Some researchers also do not know why some people without genetic mutations are susceptible to type 2 diabetes while others do not.

However, certain risk factors such as overweight and obesity (overexpression of fatty tissue that causes insulin resistant),  physical inactivity, family history, race,,,,, and age. ... 

Women developed gestational diabetes, polycystic ovary syndrome,.... and high blood pressure is also some major risk factors associated to increase the risk of type 2 diabetes.

The first line medicine used for the treatment of type 2 diabetes is metformin which processes a significant effect in improving the body tissue sensitivity to insulin. In other words, metformin improves the body uses insulin more effectively. and lowers glucose production in the liver.

In the stage prediabetes, patients may not experience any symptoms. However, untreated diabetes or diabetes that do not manage properly, may increase the risk of cataracts and glaucoma, foot damage.

In advance stage, untreated diabetes can also cause nerve damage or poor blood flow to the feet which in turn, increases the risk of various foot complications.

Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, It has been cultivated all over the world as hay for cattle feeding.

The leaves, sprouts, and seeds to make medicine has been used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney, and urinary tract infection, etc. North America aboriginal has used Alfalfa seed as food, such as making bread and mush.

Ingredients
1. Essential amino acids
2. Calcium
3. Magnesium
4. Potassium
5. Iron
6. Phosphorus
7. Zinc
8. Beta carotene
9. vitamin C
10. vitamins D
11.Vitamin E
12. Vitamin K

It chemical constituents include flavones, isoflavones, sterols, Bichanin, Coumestrol, Diadzein, Formonetin, Genistein,.... and  coumarin derivatives.

In the study to examine the Lucerne (alfalfa) effect by oral administrated the herbal extract through diet (62.5 g/kg) and drinking water (2.5 g/l) in reducing the hyperglycemia of streptozotocin-diabetic mice, researchers found
* Application of aqueous extract of lucerne exerts a significant stimulation of insulin secretion from the pancreatic B-cell line.

* Application of aqueous extract of lucern also promotes insulin-like activity in inhibited overexpression glucose.

* The sequential extraction with solvents revealed .higher insulin-releasing activity in both methanol and water fractions compared to one extract constituent.

Further analysis also suggested that the activity of the extract was found to be heat stable and enhanced by exposure to acid and alkali (0.1 M-HCl and NaOH).

Dr. Gray AM, the lead author at the final report wrote, "The results demonstrate the presence of antihyperglycaemic, insulin-releasing and insulin-like activity in the traditional antidiabetic plant, Medicago sativa".

Additionally, in the study to reaffirm the effect herbal alfalfa against onset of diabetes researchers launched a study to compare alfalfa with other herbal medicine including dried leaves of agrimony (Agrimonia eupatoria), blackberry (Rubus fructicosus), celandine (Chelidonium majus), eucalyptus (Eucalyptus globulus), lady's mantle (Alchemilla vulgaris), and lily of the valley (Convallaria majalis); seeds of coriander (Coriandrum sativum); dried berries of juniper (Juniperus communis); bulbs of garlic (Allium sativum) and roots of liquorice (Glycyrhizza glabra).

In mice administrated by streptozotocin (200 mg/kg i.p.) to induce the development of hyperphagia, polydipsia, body weight loss, hyperglycemia and hypoinsulinemia, researchers found that

* Herbal alfalfa exerts a strong effect in reduced the level of hyperglycemia during the development of streptozotocin diabetes compared to others herbs.

* Herbal alfalfa reduced polydipsia and a reduced rate of body weight loss.

* Alfalfa initially countered the hyperinsulinaemic effect of streptozotocin, without affecting the fall in plasma insulin.

Dr. said, after taking into account of other co and confounders, " The results suggest that certain traditional plant treatments for diabetes, namely alfalfa,.......can retard the development of streptozotocin diabetes in mice".

Taking all together, herbal alfalfa may be considered a functional herb for the prevention and treatment of type 2 diabetes.

 However, additional data collection on large example size and multi-center clinical studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of alfalfa anti-type 2 diabetes possibilities.

And long-term multiple dietary supplement consumption of a broad array of vitamin/mineral, herbal, and condition-specific dietary supplements on a daily basis should consult with their doctors or related field specialist before applying.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Holistic System In Existence That Will Show You How To
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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Pancreatic and extra-pancreatic effects of the traditional anti-diabetic plant, Medicago sativa (lucerne) by Gray AM, Flatt PR. (PubMed)
(2) Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. by Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. (PubMed)
(3) Drug-induced lupus: an update by Vasoo S.(PubMed)

Anise, The Herb Which Exerts Antinociceptive Activity Against Primary Dysmenorrhea, Scientist Find

By Kyle J. Norton, Master of Nutrition

Herbal  Anise may process an antinociceptive activity in reducing the expression of primary dysmenorrhea, some scientists suggested.

Primary dysmenorrhea pain is a menstrual pain caused by sensory neurons stimulus triggered by overproduction prostaglandins, hormones that lead to uterus contract before or during menstruation.
Antinociceptive activity is an action or process of blocking the painful or injurious stimulus by sensory neurons.

Some women may experience periodic pains during or prior to, or after menstrual periods in the lower abdomen.

In traditional Chinese medicine, dysmenorrhea is defined as a pain in the lower abdomen that can spread over to the whole abdomen and lumbosacral region, depending on the diagnosis.

According to statistic, primary dysmenorrhea affects more than 50% of women in late adolescence and the early 20s. Most primary dysmenorrhea appears 6 to 12 months after the first period due to immature of the reproductive organs of young girls,
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belonging to the family Apiaceae native to Egypt and the Mediterranean region.

The popular herb has been used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, antiseptic, anti-spasmodic, carminative, digestive, expectorant, stimulant and tonic agent and to treat head-lice and mites, increase blood pressure, prevent formation of gas in the gastrointestinal tract,.... and menstrual cramps.

The Chemical Ingredients
Besides the main ingredient Anethole, herbal anise also contains, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

In the finding of natural ingredient treat primary dysmenorrhea without inducing side effects, Dr. Khodakrami Nahid, MSM and colleague conducted a study to examine the effect of an Iranian herbal drug in the treatment of primary dysmenorrhea.

The randomized, double-blind, placebo-controlled pilot trial among 180 female students at Isfahan University dormitory aged 18 to 27.

Participants were randomly divided into three groups: herbal drug were given 500 mg of highly purified saffron, celery seed, and anise (SCA) extracts three times a day for three days, starting from the onset of bleeding or pain,  mefenamic acid, and placebo.

After following the participants for two to three cycles from the beginning of menstruation through the three days of bleeding and the severity and duration of pain at 2 and 3 months were measured.

At the final report of the study, researchers filed,

* Women received Anise extract and mefenamic acid showed a statistically significant reduction in pain scores and pain duration scores.

*  The decrease in pain score was reflected by a significant reduction in other herbal drug use among the treatment groups compared to the placebo group but lesser compared to Anise group.

* Application of Anise extract demonstrated a  magnitude of the reduction which is significantly greater compared mefenamic acid and placebo groups.

* However, both herbal drugs and mefenamic acid effectively relieved menstrual pain as compared with the placebo.

These results suggested that herbal Anise processed strong antinociceptive activity against pain caused by primary dysmenorrhea may be considered as a functional herb for the treatment of primary dysmenorrhea.


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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
1. Herbal combination for primary dysmenorrhea by Tori Hudson, ND
2. The effect of an Iranian herbal drug on primary dysmenorrhea: a clinical controlled trial.

Arnica, The Herb Which Speeds Up Bruise Healing, Scientists Reveal

Herbal Arnica may process a property of speeding bruise healing without inducing adverse effects, some studies suggested.

A bruise is a condition characterized by black and blue marks on the skin due to trauma, caused by an object or force strikes the body, leading to damage to capillaries and sometimes venules that allow blood to seep, hemorrhage, or extravasate into the surrounding interstitial tissues.

A bruise can also be induced by surgery caused by instruments which pierce into the deep layer of the skin to create an opening.

Most Bruising resolves themselves in a few days or weeks.

Some bruise may cause pain but the pain usually goes away when the color of the area fades away. 

Bruising, also known as a contusion, is defined as a condition of 

Some researchers suggested that

Most common causes of bruising are sport related. 

Sport physical activities can sometimes cause broken bones, strains and sprains, dislocations, torn tendons,..... and muscle swelling. Overuse of body muscles in sport is one of risk factor that can cause, inducing bruising.

Ice and heat therapies by Appling ice or heat immediately after the injury to reduce blood flow around the area. were found to be effective in preventing bruising.

Arnica is a herbaceous species, genus perennial, belonging to the family Asteraceae, native to Europe and Asia.

The herb has been used in traditional medicine for centuries to treat strains, sprains, and bruises.

The chemical ingredients besides major bioactive compound helenalin, Anica also contains 11,13- dihydrohelenaline, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside,..... and six dibenzylbutyrolactol derivatives.

In the assessment of the comparative utility of topical formulations in hastening the resolution of skin bruising, researchers at the Northwestern University, conducted a double (patient and rater) blinded randomized controlled trial with numbers of healthy volunteers, age range 21-65 years.

After four standard bruises of 7 mm diameter each were created on the bilateral upper inner arms, 5 cm apart, two per arm, using a 595-nm pulsed-dye laser (Vbeam; Candela Corp., Wayland, MA, U.S.A.). on each subject, each bruising area was injected by one topical agent, including 5% vitamin K, 1% vitamin K and 0·3% retinol, 20% arnica, or white petrolatum, twice a day for 2 weeks.

At the end of the 2 weeks experiment, researchers found that

* All four treatment score a significant improvement in the change in the rater bruising score.

* The mean improvement associated with 20% arnica was greater than with white petrolatum (P=0·003), and the mixture of 1% vitamin K and 0·3% retinol.

* However, 5% vitamin K cream processes the highest bruise healing score compared to other applications.

These results suggested that topical 20% Arnica ointment may be able to reduce bruising more effectively than placebo and more effectively than low-concentration vitamin K formulations, such as 1% vitamin K with 0·3% retinol.

In  a double-blind, placebo-controlled, randomized trial with three parallel arms to reaffirm Arnica efficacy in the control of bruising, reducing swelling and promoting recovery after local trauma,  64 adults undergoing elective surgery for carpal tunnel syndrome were randomized to take three tablets daily of homeopathic Arnica 30C or 6C or placebo for seven days before surgery and fourteen days after surgery.

According to the summary of the experiment final report, researchers showed

* There were no group differences on the primary outcome measures of pain (P=0.79) and bruising (P=0.45) at day four.

* Swelling and use of analgesic medication also did not differ between arnica and placebo groups.

* Adverse events were reported by 2 patients in the arnica 6C group, 3 in the placebo group and 4 in the arnica 30C group.

These results strongly indicated that Arnica does not process analgesic property.

Moreover, in the study to assess Arnica decreases bruising and muscle pain efficacy, the Memorial Family Medicine Residency Program conducted a randomized, double-blind, placebo-controlled trial including 53 subjects.

Measurement of ankle range of motion and muscle tenderness were also recorded during Leg pain induced by calf raises.

Then, each participant received 2 tubes of cream, 1 with active Arnica and 1 with placebo.

The creams were applied to the lower legs immediately after the exercise, and again at 24 and 48 hours post-exercise according to the "RIGHT" or "LEFT" labels.

At 48 hours post-exercise, subjects had their ankle range of motion and muscle tenderness measured.

Subjects used the analog scale to rate pain in each leg at baseline, 24 hours, 48 hours, and 72 hours.

At the final day of study, by analyzing the reported returned by participants, scientists found that

* No significant differences in pain scores were seen before exercise.

* Pain scores on legs treated with Arnica were higher than scores on those receiving placebo 24 hours after exercise respectively.

* Pain scores on day 3 and day 4 were not significantly different.

* There was no difference in muscle tenderness.

* Ankle range of motion did not differ significantly on either day 1  or day 3.

Dr. Adkison JD, the lead author suggested, Arnica may increase pain in the affected area within 48 hours immediately after application.

Taking all together, herbal Arnica may be used as a therapeutic treatment for speeding up bruise healing however, patients should be aware that topical application of herbal Arnica does not process analgesic property. In some cases, it may increase pain in the affected area.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
2. Accelerated resolution of laser-induced bruising with topical 20% arnica: a rater-blinded randomized controlled trial. by Leu S, Havey J, White LE, Martin N, Yoo SS, Rademaker AW, Alam M.(PubMed)
3. Homeopathic arnica for prevention of pain and bruising: randomized placebo-controlled trial in hand surgery. by Stevinson C, Devaraj VS, Fountain-Barber A, Hawkins S, Ernst E.(Pubmed)
4. The effect of topical arnica on muscle pain" by Adkison JD, Bauer DW, Chang T., (PubMed).
5. Cosmetics and herbal remedies with Compositae plant extracts - are they tolerated by Compositae-allergic patients?" by Paulsen E, Chistensen LP, Andersen KE., (PubMed)
6. Contact allergy to Compositae plants in patients with atopic dermatitis. [Article in English, Serbian]" by Jovanović M, Poljacki M, Duran V, Vujanović L, Sente R, Stojanović S., (PubMed)

Alternative Therapy: Yoga In Prevention and Treatment of Neurological Disorders

Kyle J. Norton (Master of Nutrients, All right reserved)

Yoga, an integrated form of exercise may be used for reduced risk and treatment of neurological  disorders, some scientists suggested.

Neurological disorders are medical condition characterized by any disorder of the nervous system caused by structural, biochemical or electrical abnormalities.

There are many forms of neurological  disorders. The most common types of the disease include neurodegenrative disease, such as Alzheimer's disease (AD) and Parkinson's disease, epilepsy. multiple sclerosis and Migraines.

According to the Medical press, globally, the burden of neurological disorders (Alzheimer's disease, Parkinson's disease, stroke, epilepsy etc) has increased substantially over the past 25 years. These may be results of over 25 years of economic expansion that have increased living standard of billion of people in the Southeast Asian region.

Today, people who have made a lots of money in that region have abandoned traditional diet with abundant vegetables and fruits and replaced them  with Western diet which is considered as a risk factor of neurological  disorders.

A new report from the World Health Organization (WHO) showed that neurological disorders, ranging from epilepsy to Alzheimer disease, from stroke to headache, affect up to one billion people worldwide. And, An estimated 6.8 million people diet every year as a result of neurological disorders.

 

In Europe alone, neurological diseases cost the health care system an estimation of 139 billion euros in 2004.

Yoga, the ancient  technique practice for harmonized external and internal body well being, through breath control, meditation, bodily movement and gesture..... has been well known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In a review of literature published online, including randomized, controlled trials with yoga as the central component of the intervention, researchers filed the following reports
*  6 selected trial expressed a significant effect of yoga lessons in reduced symptoms and treatment of neurological disorders
* 10 out 13 trials chosen indicated a positive effect in use of yoga as as an ancillary treatment of in patients with psychiatric disorders.

Researchers also note that Trials were excluded in these review if yoga was not the central component of the intervention.

These results suggested that long term participation in yoga affects the adrenal gland of central nervous system in production of hormones which have strong implications on stress and anxiety, such as serotonin, adrenaline and cortisol.

Further more, yoga meditation and posture also enhanced blood circulation to the central nervous system, thus reducing risk of neurological disorders.

Also in the review of article used comprehensive scientific, evidence-based studies to analyze the efficacy of various basic and applied aspects of yoga in disease prevention and health promotion, particularly in neurological disorders from various resources including PubMed, Ovid, MD-Consult, USC, and U.C.L.A. libraries, researchers at the USC, after adjusting to other co confound factors, indicated that patients who participated in the class of yoga demonstrate statistically encouraging physiological and psychological improvements in the aforementioned neurological disorders.

Additionally, in the investigate promotion of mind-body medicine for health promotion, disease prevention and as a possible treatment modality for neurological disorders, researchers at the S-VYASA University performed a comprehensive search in the PubMed/Medline found that 94 out of 700 examine demonstrated a strong improvement in patients with various neurological disorders

Martin Jones, the lead author in the article of Yoga for Neurological Health, For those with MS, Parkinson's, or Other Neurological Disorders wrote, " (Yoga) Exercises that train neuromuscular coordination, as well as draw vitality and strength to all parts of the body" and "Techniques to draw on the healing aspects of the parasympathetic (“rest and repose”) nervous system and meditation to retrain the brain and create more efficient pathways to the pre-frontal lobes, the most highly evolved part of our nervous system, where we experience our most inspired, creative thinking and elevated levels of consciousness".

Base on information collected, there is no doubt that yoga may be considered as secondary form of exercise used conjunction with standard application for reduced symptoms and treatment of neurological  disorders


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299

Sources
(1) Yoga as an ancillary treatment for neurological and psychiatric disorders: a review by Meyer HB1, Katsman A, Sones AC, Auerbach DE, Ames D, Rubin RT.(PubMed)
(2) The therapeutic value of yoga in neurological disorders by Mishra SK1, Singh P, Bunch SJ, Zhang R.(PubMed)
(3) Evidence based effects of yoga in neurological disorders by Mooventhan A1, Nivethitha L2(PubMed)
(4) Yoga for Neurological Health, For those with MS, Parkinson's, or Other Neurological Disorders, Led by Maitri Jones

How to Protect Your Stomach Against Onset of Atrophic Gastritis and Gastric Cancer

By Kyle J. Norton, Master of Nutrition

Scientists may have found a whole food which has a unique function in protecting the stomach against the onset of atrophic gastritis and gastric cancer, some studies suggested.

Atrophic gastritis is a condition of loss of gastric glandular cells caused by long-term inflammation of the stomach mucous membrane (mucosa).

Loss of the gastric glandular cells in the long term eventually is replaced by intestinal and fibrous tissues.

Gastric cancer is a medical condition characterized by irregular and uncontrollable cell growth in the stomach lining in the beginning. At the advanced stage, the malignant cells can travel a distance away through blood and fluid circulation to infect other healthy tissue and organs.

Researchers do not know why some people with the same health condition are susceptible to the risk of gastric cancer, while others do not. The exact causes of gastric cancer are also unknown. However, some researchers suggested that Age, diet, and stomach disease, such as can increase the risk of developing gastric cancer.

Both atrophic gastritis and gastric cancer share the common symptoms of stomach pain, nausea and vomiting, loss of appetite,... and indigestion. However, common symptoms of unexpected weight loss and stomach ulcers can only be found in gastric cancer while iron deficiency anemia is found in the majority of patients with atrophic gastritis.

If you experience some of the above symptoms, please see your doctor to rule out gastric cancer possibility.

Celery is a species of Apium graveolens, belongings to the family Apiaceae, cultivated all around the globe as a vegetable.

Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.

In vitro, with an aim to find the natural ingredient from food sources for treatment of atrophic gastritis and gastric cancer without inducing adverse effects, researchers conducted an experiment, including 5-8 week-old Mongolian gerbils inoculated with Helicobacter pylori for four weeks without (atrophic gastritis group) or with N'-methyl-N'-nitro-N-nitroso-guanidine (MNNG) (gastric cancer group) in drinking water, and were then rested for two weeks.

During the 7th-32th (atrophic gastritis group) or the 7th-52th (gastric cancer group) weeks were given various doses (0-60 mg/kgbw/day) of apigenin, a major bioactive compound isolated from celery.

Observation at the end of the 32th (atrophic gastritis group) or the 52th (atrophic gastritis group) week, after sacrificing, researchers found that
*Application of Apigenin at the doses range from 30-60 mg/kgbw/day effectively decreased atrophic gastritis (atrophic gastritis group) and dysplasia/gastric cancer (gastric cancer group).

* Apigenin treatment (60 mg/kgbw/day) significantly decreased Helicobacter pylori colonization and Helicobacter pylori-induced histological changes of neutrophil and monocyte infiltrations and atrophic gastritis in both atrophic gastritis and gastric cancer.

These results suggested that apigenin isolated from celery processes a remarkable ability to inhibit Helicobacter pylori-induced atrophic gastritis and gastric cancer progression as well as possessing potent anti-gastric cancer activity.

Additionally, the study in finding of natural compound which processes mechanisms of apoptosis in tumor cells for tumor therapy and cancer molecular biology and inhibits loss of cell cycle control, leading to uncontrolled proliferation in healthy cells, suggested that celery seed extract (CSE), in a dose- and time-dependent manner, exhibited anti-proliferation effect on human gastric cancer BGC-823 cells, through cell cycle arrest and apoptosis-related proteins.

Dr. Gao LL, the lead scientist said, at the end of the experiment, "The molecular determinants inhibition of cell proliferation, as well as apoptosis of CSE, may be associated with cycle arrest in the S phase".

Furthermore, Celery seed oil, in benzo[a]pyrene- (BP) induced forestomach cancer in mice, the chemical constituents. 3-n-butylphthalide and sedanolide showed to reduce tumor incidence from 68% to 30% and 11%, and 67% and 83% in tumor multiplicity, respectively.

These results suggest that phthalides, as a class of bioactive natural products occurring in edible umbelliferous plants, may be effective chemopreventive agents for cancer.

Moreover, in the differentiation of the nutritional epidemiology of gastric cancer in 293 cases and neighborhood-, age-, and sex-matched controls in communities throughout the counties of Niagara, Monroe, and Erie in western New York researcher discovered that ingestion of carotene from raw vegetables (including celery, cucumbers, carrots, green peppers, tomatoes, and onions), as well as with the increased use of low-temperature food storage exerts a significant inhibition of oxidation products that could act as carcinogens in the stomach.

Taken altogether, celery whole food and celery seed containing high amounts of bioactive Apigenin  and phthalide, respectively may be used to prevent and treat atrophic gastritis and gastric cancer without no adverse effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Apigenin has anti-atrophic gastritis and anti-gastric cancer progression effects in Helicobacter pylori-infected Mongolian gerbils by Kuo CH1, Weng BC2, Wu CC3, Yang SF4, Wu DC5, Wang YC(PubMed)
(2) Molecular mechanisms of celery seed extract induced apoptosis via s phase cell cycle arrest in the BGC-823 human stomach cancer cell line by Gao LL1, Feng L, Yao ST, Jiao P, Qin SC, Zhang W, Zhang YB, Li FR(PubMed)
(3) Chemoprevention of benzo[a]pyrene-induced forestomach cancer in mice by natural phthalides from celery seed oil by Zheng GQ1, Kenney PM, Zhang J, Lam LK(PubMed)
(4) Diet in the epidemiology of gastric cancer by Graham S1, Haughey B, Marshall J, Brasure J, Zielezny M, Freudenheim J, West D, Nolan J, Wilkinson G.(PubMed)

Asparagus, The Vegetable Which Boosts The Body's Defense System Against Onset of Diseases, Scientists Reveal

Asparagus may have a profound effect to stimulate immune system fighting against foreign invasion, some scientists suggested.

Immunomodulators are agents that have unique functions to modify the immune response or the functioning of the immune system such as  the stimulation of antibody formation or the inhibition of abnormal white blood cell activity.

In other words, immunomodulation processed immunotherapy, in which immune responses are induced depending to the body needs.

The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases. 

The immune system does a great job of keeping people healthy and preventing infections. 

Beside foods and nutritional supplements, herbs also play important roles in helping the immune system defend against viruses and bacteria attacks.

Asparagus is a flowering plant belong to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa and western Asia. 

The herb has been used in early times as a vegetable and medicine, because of its delicate flavor and diuretic properties. Asparagus racemosus Linn. (Fam. Liliaceae) is considered as an ethno-pharmacologically acclaimed Ayurvedic medicinal plant which may enhance immune function.


Nutrients and chemical constituents
1. Vitamin K
2. Folate
3. Vitamin C
4. Vitamin A
5. Vitamin B Complex
a) Vitamin B1
b) Vitamin B2
c) Vitamin B3
d) Vitamin B6
6. Fiber
7. Manganese
8. Copper
9. Phosphorus
10. Potassium
11. Protein

Its chemical constituents include essential oils, asparagine, arginine, tyrosine, flavonoids (kaempferol, quercetin, and rutin), resin, and tannin.

According to study, application of aqueous extract of A. racemosus (ARC) showed a dose-related stimulation of NK cell activity.

More precisely, ARC demonstrated a higher immune stimulatory activity upto  51.8% at dose of  25 μg/ml.

Furthermore, in the searching for natural immunomodulatory agents where decrease of parasitic burden and simultaneous enhancement of adaptive immunity can be achieved in replacement of current drugs for the treatment of visceral leishmaniasis with side effect of suppressesing immune function during the course of infection, researchers at the Panjab University, launched an investigation based on combination of Asparagus racemosus, an immunomodulatory drug, in combination with cisplatin against Leishmania donovani infected BALB/c mice.

Experiential mice were given A. racemosus (650 mg/kg b.wt./day for 15 days, orally) in combination with cisplatin (5 mg/kg b.wt./day for 5 days, intraperitoneally) with an aim to enhance the clearance of parasites determined by Giemsa-stained liver impression smears.

At the the end of study, researchers found that 

* Application of combination group achieved increased production of disease resolving Th-1 response (IFN-gamma, IL-2), heightened DTH (delayed type hypersensitivity) response and augmented levels of IgG2a

IFNγ, or type II interferon, a cytokine plays an important role in regulate innate and adaptive immunity against viral, some bacterial and protozoal infections

Interleukin-2 (IL-2), a type of inflammatory cytokine with function that signals molecule in the immune system plays a critical role to regulate the activities of white blood cells in response to immunity.

Delayed-type hypersensitivity (DTH) is an inflammatory response of immunity that develops within 24 to 72 hours after exposure to an antigen.

IgG2a is antibody produced during immune response.

* The combined application  not only provided enhanced protective immune response but also resulted in remarkable improved kidney and liver function. the human detoxed organs. 

Moreover, researchers also discovered, the combined application  also boosts and restores both cellular and humoral immunity in L. donovani infected BALB/c mice.

Dr. Sachdeva H, the lead author after taking into account of others co and con founders said, "....in view of severe immunosuppression in visceral leishmaniasis, a better and effective strategy for optimum efficacy of future antileishmanial drugs would direct not only killing of parasite by the drug, but also simultaneous generation of immunity against the disease".

Taking altogether, herbal Asparagus used alone or conbination with cisplatin may have strong effect in boosting immune system against foreign invasion through mmunomodulatory activity.

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Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299


References
(1) Chemical constituents of Asparagus J. S. Negi, P. Singh, [...], and V. K. Bisht (PubMed)
(2) Characterization and in vitro immunomodulatory screening of fructo-oligosaccharides of Asparagus racemosus Willd. by Thakur M, Connellan P, Deseo MA, Morris C, Praznik W, Loeppert R, Dixit VK.(PubMed)
(3) Asparagus racemosus ameliorates cisplatin induced toxicities and augments its antileishmanial activity by immunomodulation in vivo. by Sachdeva H, Sehgal R, Kaur S.(PubMed)

Black beans, The Legume Which Restores The Ratio of Free Radicals and Antioxidants in Our Body

By Kyle J. Norton, Master of Nutrition

Black beam with abundant nutrients and phytochemicals may have a profound effect in restoring the health of human systems by rebalancing the ratio of reactive oxygen species and antioxidants in the body, some scientists suggested.

A free radical is an atom that has a single unpaired electron in an outer shell and highly reactive to react with other cell, which in turn, causes oxidative damage to the enzymes, protein, unsaturated fatty acid, phospholipids, DNA..... and RNA through a set of chain reaction auto-catalytically after attacking the lipid bilayers of the cell walls.

Epidemiological studies agreed that overexpression of free radicals is an association of a wide range of medical conditions including chronic syndromes and diseases.

Antioxidants, opposite to free radicals are substances that inhibit free radicals activity in the induction of oxidation.

In a healthy individual, antioxidants produced by antioxidant enzymes, including superoxide dismutase (SOD), glutathione peroxidase, glutathione reductase, and catalases found in the tissue are more than enough to balance the ratio of ROS and antioxidant which in turn enhances the function of body systems in protection against diseases associated to overexpression of free radicals.

However, in the prevention of free radicals in the induction of diseases, some people may opt for supplementation, including free radical scavenging antioxidant vitamins, such as vitamins A, C, E, folic acid, and beta-carotene.

Some researchers suggested, phytochemical produced by plants with a function to protect the plant to grow and defense against competitors, pathogens, or predators may also improve antioxidant status in the body if they are consumed by a human.

Black bean is a Small roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae.

Dried and canned forms of black beans can be bought in most grocery stores all around the year in . It is believed that black bean was first domesticated growth in South America.

Nutrients and Chemicals constituents 
a. Nutrients
1. Carbohydrate
2. Dietary fiber
3. Protein
4. Fat
5. Vitamin A
6. Vitamin B
7. Folate
8. Vitamin C
9. Calcium
10. Magnesium
11. Manganese
12. Phosphorus
13. Molybdenum
14. Iron

b. Chemicals constituents
The major chemical compounds of black bean include anthocyanin, (-)-epicatechin, delphinidin, petunidin, flavonols, and malvidin.


In the study to classify the maximum antioxidant effect of legume including black and red varieties of adzuki beans, researchers found that Adzuki bean (black) contain high levels of antioxidant 2,2'-diphenyl-1-picrylhydrazyl and superoxide anion scavenger compared to other beans.
* Adzuki bean (black) also processes the hydrogen peroxide scavenging and metal chelating abilities, but lesser compared to adzuki bean (red) variety.

* Phenolic extracts found in black adzuki bean also showed distinct variations compared to other beans in the inhibition of enzymes associated with hyperglycemia and hyperlipidemia.

* α-glucosidase inhibitory activity was superior in the black variety of adzuki bean (IC(50,) 26.28 mg/mL), both adzuki bean varieties (black and red) with no significant difference in their IC(50) values (7.32 to 9.85 mg/mL).

Dr. Sreerama YN, the lead scientist at the final report of the study wrote." Vigna species of legumes are a potential source of antioxidant phenolics and also great sources of strong natural inhibitors for α-glucosidase and lipase activities" and "Vigna species of legumes are good sources of phenolic antioxidants and strong natural inhibitors of enzymes associated with diabetes and obesity".

Furthermore, with an aim to reaffirm the antioxidant status of varieties of legume species, researchers at the Bhabha Atomic Research Center launched an investigation using numbers of a different technique, including Ferric Reducing Antioxidant Power (FRAP) and metal ion (Fe²⁺) chelation assays.

Thirty different varieties of commonly consumed legumes in India were screened for phenolic content and antioxidant in the study.

All 30 bean varieties process a high level of antioxidants. Beans with a dark coating such as black bean have higher levels of antioxidants compared to beans with the lighter coating.

Moreover, Antioxidant activity showed a positive correlation (r²>0.95) with phenolic contents.

These result suggested that black color bean may be considered functional food in improved antioxidants in the body. In other words, intake of black bean daily may protect us against chronic syndromes and diseases caused by an imbalance of ratio free radicals and antioxidants in our body.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299

References 

(1) Differential accumulation of polyphenolics in black beangenotypes grown in four environments.
Marles MA, Balasubramanian P, Bett KE. (PubMed)
(2) Phenolic antioxidants in some Vigna species of legumes and their distinct inhibitory effects on α-glucosidase and pancreatic lipase activities by Sreerama YN, Takahashi Y, Yamaki K. (PubMed)
(3) Comparative study on antioxidant activity of different varieties of commonly consumed legumes in India. by Marathe SA, Rajalakshmi V, Jamdar SN, Sharma A.(PubMed)