Carrots May Stop Colon Cancer Cells From Spreading, Scientists Say

Kyle J. Norton

Carrots may have a profound and substantial effect on blocking colon cancer cells from spreading, some scientists suggested.

Colon cancer, the third most common type of cancer in the United States, is a condition characterized by cell growth disorderly and uncontrollably in colon tissue. At the later stage, the cancerous cells may infect other healthy tissue and organs a distance away from the original site.

According to statistics provided by the American cancer society, in the US, 135,430 new cases colon cancers were diagnosed and 50,260 patient died from colon and rectal cancers in 2017.

Sadly. 1 in 22 men and 1 in 24 women will be diagnosed with colorectal cancer in their lifetime.

The exact causes of colon cancer are unknown, some researchers suggested that increasing age, African-American race, high fat intake, a family history of colorectal cancer, patients with polyps in the large intestine, and inflammatory bowel diseases, and chronic ulcerative colitis are associated to increase risk of the disease onset.

Besides the common cancers symptoms, patients with colon cancer may also experience, a change in  bowel habits, that lasts longer than 3 weeks, persistent rectal bleeding or blood in your stool,... and abdominal discomfort, such as cramps, gas or pain.

Dr. O'Neill AM, the lead scientist in concern of Western diet in risk of colon cancer, wrote in his vitro, "Human colon cancer growth is accelerated in animals that are obese and insulin resistant due to the consumption of an high-fat Western diet (HFWD)"(4).

Carrot, a root vegetable with orange color is  a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

In an aim to evaluate the effect of carrot intake and risk of colon cancer, researchers at the Technical University of Munich conducted a randomized cross-over trial of twenty-two healthy young men on a low-carotenoid diet consumed 330 ml tomato or carrotjuice per day for 2 weeks with intervention periods preceded by 2-week depletion phases.

At the end of the experiment,  researchers found that increased marks of beta-carotene and alpha-carotene were found in the collected feces

Further analysis of fecal water, researchers indicated that intake of tomato and carrot juice demonstrates a huge activity in induction of cytotoxic and anti-proliferative effects on colon adenocarcinoma cells (HT29) in high dose-dependent manner without alternating the bile acid concentrations, activities of the bacterial enzymes beta-glucosidase and beta-glucuronidase.

Moreover, intake of tomato and carrot juice also decreased fecal water pH, another indication of anti colon activity that was attributed to short chain fatty acids (SCFAs) concentration with function in regulated cecal and colonic metabolism and modulated histone acetylation in human HT29 colon cancer cells.

After taking into account of other con founders, Dr. Schnäbele K, the lead author said, "2-week interventions with carotenoid-rich juices led only to minor changes in investigated luminal biomarkers relevant to colon carcinogenesis".

Additionally, in the reaffirmation of wild carrot used in folk medicine throughout the world for anticancer and antioxidant activities, researchers at the joint study lead by the University of Surrey conducted an experiment to evaluate the effect of pentane fraction (F1) and the 1:1 pentane:diethyl ether fraction (F2) of the Daucus Carota oil extract (DCOE) in human colon adenocarcinoma cell lines (HT-29 and Caco-2).

The results of the study suggested that application of the extract F1 and F2 exerts a profound effect in inhibition of colon cell proliferation in a dose-dependent manner.

According to the Flow cytometric analysis, both fractions ameliorated colon cells expression through significantly induced sub-G1 phase accumulation and increased apoptotic cell death. 

In the Western blot assay, researchers found that application of F1 and F2 also reduces cancer cell proliferation through activation of caspase-3 which is considered as a 'death-switch' in colorectal cancer cells.

Administration of F1 and F2 also increased expression of Bax in penetration of the cancer mitochondrial outer membrane to mediate cell death by apoptosis. and p53 with function in exhibited cancer cell growth arrest and inhibited cancer cells proliferation.

The fractions also decreased levels of Bcl-2 in inhibited PARP cleavage activity in facilitation of colon cancer cell apoptosis.

 This implication suggested that F1 or F2 inhibited colon cancer cells through ameliorated expression of phosphatidyl inositol 3-kinase (PI3K) pathway which has the function to act as a key mediator of cell metabolism and cell growth at different levels. 

More importantly, injection of DCOE fractions (F1 and F2) also attenuated cell proliferation by inducing cell cycle arrest and apoptosis in HT-29 cells.

The findings strongly suggested that carrot can be considered as a function food in prevention and treatment of colon cancer. But Intake of carrot supplement should be taken with care to prevent acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299

Sources
(1) Daucus carota Pentane-Based Fractions Suppress Proliferation and Induce Apoptosis in Human Colon Adenocarcinoma HT-29 Cells by Inhibiting the MAPK and PI3K Pathways by Shebaby WN1, Bodman-Smith KB1, Mansour A2, Mroueh M3, Taleb RI4, El-Sibai M4, Daher CF(PubMed)
(2) Effects of carrot and tomato juice consumption on faecal markers relevant to colon carcinogenesis in humans by Schnäbele K1, Briviba K, Bub A, Roser S, Pool-Zobel BL, Rechkemmer G(PubMed)
(3) Inhibitory effects of feeding with carrots or (-)-falcarinol on development of azoxymethane-induced preneoplastic lesions in the rat colon by Kobaek-Larsen M1, Christensen LP, Vach W, Ritskes-Hoitinga J, Brandt K(PubMed)
(4) High-fat Western diet-induced obesity contributes to increased tumor growth in mouse models of human colon cancer by O'Neill AM1, Burrington CM2, Gillaspie EA3, Lynch DT2, Horsman MJ2, Greene MW(PubMed)

Detoxification: Cruciferous Vegetables Promote Functions of Detox Enzymes Against Substances and Radiation That Cause Prostate Cancer

By Kyle J. Norton, Master of Nutrition

Cruciferous vegetables may be considered as next plants, processing pharmaceutical value in extraction of single ingredient chemo medicine of blocking onset of prostate cancer, some scientists suggested

Prostate cancer is a condition characterized by irregular and uncontrollable growth of  the cells of prostate. In the advance stage, the cancerous cells can spread to the distant parts of the body through blood and fluid circulation.

Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the physical (rectum) exams.

According to statistic provided by the Canadian government, 1 in 7 men will develop prostate cancer during their lifetime, and 1 in 27 will die of it.

Sadly, out of 4 men diagnosed with prostate cancer, 1 will die of it. which is very similar to the ratio observed for breast cancer in women. 

A diagnosis of prostate cancer carries a significant burden of induction of significant anxiety and depression.

Researchers do not know the exact causes of prostate cancer and can not explain why some men  who do process inherited gene mutation are susceptible to onset of prostate cancer while others do not.

But they do know that some risk factors such as age, family history, race and diet are associated to the development of prostate cancer. 

Early diagnosed for prostate cancer patients have a 5-year survival rate nearly 100% with 98% of these patients are still alive after 10 years compared to 5-year survival rate of advance stage of 30%.

Therefore, if you are at the high risk of prostate cancer development group, please make sure that you have your prostate gland checked every year.

Cruciferous vegetables are the group of vegetables included cauliflower, cabbage, cress, bok choy,..... and broccoli.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae.

The healthy veggie has large flower heads, usually green in color and the mass of flower heads, surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

Nutrients and chemical constituents
1. Carbohydrates
2. Sugars
3. Dietary fiber
4. Omega 3 fatty acid
5. Protein
6. Beta-carotene
7. Lutein and
8. Zeaxanthin
9. Thiamine (Vitamin B1)
10. Riboflavin (Vitamin B2)
11. Niacin (Vitamin B3)
12. Pantothenic acid (B5)
13. Vitamin B6
14. Folate (Vit. B9)
15. Vitamin C
16. Calcium
17. Tryptophan
18. Iron
19. Magnesium
20. Phosphorus
21.Potassium
22. Zinc
23. Etc.
Its chemical constituents includes  glucosinolates, dithiolthiones, indoles , glucoraphanin, s-methyl cysteine sulfoxide, isothiocyanates, indole-3-carbinol, etc..


Epidemiologically, chemical constituents of cruciferous vegetables, such as broccoli has shown to decrease incidence of prostate cancer.

In the finding of broccoli effect in genetic implication of risk of prostate cancer, researchers at the Institute of Food Research conducted a study which includes
volunteers with or without genetic mutation of glutathione S-transferase mu 1 (GSTM1) positive and null.

Glutathione S-transferase (GST) are detox enzymes with function involved detoxification of many potentially carcinogenic compounds.

Participants were randomly assigned to six months either a broccoli-rich or a pea-rich diet.

At the end of study, researchers found that

* Pea-rich diet shows no differences in gene expression between glutathione S-transferase mu 1 (GSTM1) positive and null individuals

* Broccoli-rich diet group exerts significant differences between GSTM1 genotypes associated with transforming growth factor beta 1 (TGFbeta1) and epidermal growth factor (EGF) signalling pathways.

* Both diets demonstrate a significant androgen signalling.

* Men on the broccoli diet had additional changes to mRNA processing, and TGFbeta1, EGF and insulin signalling. 

The growth factor beta (TGFbeta) signaling pathway is a key role in tumor suppression through modulating processes such as cell invasion, immune regulation, and microenvironment modification normally. However, the transforming growth factor beta (TGFteta) signaling pathway can cause tumor development with similar physio activity.

In  healthy and malignant cells, epidermal growth factor receptor (EGFR) allows cells to grow and divide

These results suggested that broccoli interacts processed a strong anti prostate cancer effect in patients with GSTM1 genotype associated with inflammation and carcinogenesis in the prostate gland.

Dr. Traka M, the lead author after taking into account of other factors, said, "diets rich in cruciferous vegetables may reduce the risk of prostate cancer and other chronic disease".

Furthermore, in a population-based, case-control study of prostate cancer, including 428 men with incident prostate cancer and 537 community controls with genotyping for deletions in GSTM1 and GSTT1 performed in a subset of men who provided blood, researchers found that

* Intake of cruciferous vegetables, such as broccoli, the greatest source of sulforaphane, is associated with decreased prostate cancer risk at all levels compared to the lowest consumers.

* Intake of cruciferous vegetables also displays a significantly reduced risk of prostate cancer in men with mutation of gene GSTM1. Particularly in high broccoli intake group.

The finding suggested that 2 or more servings per month of cruciferous vegetables may reduce risk of prostate cancer, especially among men with GSTM1-present alleles.

At the final of experimental report, Dr. Joseph MA, the lead scientist, wrote, "(These results) are consistent with a role of dietary ITCs as chemopreventive agents against prostate cancer..

The depletion of gene of GSTM1 genotype of Glutathione S-transferase (GST) enzymes may be associated with an increased risk of cancer as these depletion reduced the function of GST in detoxifying most potentially carcinogenic compounds.

Taken altogether, cruciferous vegetables may be considered as functional food in promoted expression of detoxified enzymes to prevent onset of prostate cancer, especially in men with genetic mutation gene GSTM1.
.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299
Reference
(1) Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate by Traka M, Gasper AV, Melchini A, Bacon JR, Needs PW, Frost V, Chantry A, Jones AM, Ortori CA, Barrett DA, Ball RY, Mills RD, Mithen RF.(PubMed)
(2) Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk by Joseph MA, Moysich KB, Freudenheim JL, Shields PG, Bowman ED, Zhang Y, Marshall JR, Ambrosone CB.(PubMed)
(3) Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells by Abdulah R, Faried A, Kobayashi K, Yamazaki C, Suradji EW, Ito K, Suzuki K, Murakami M, Kuwano H, Koyama H.(PubMed)

Herbal Andrographis, the Functional Herb Which Processes Anti Cancers Potency

By Kyle J. Norton, Master of Nutrition

Herbal Andrographis may be considered as next generation of natural chemo medicine for treatment of cancer in any stages, some scientists found.

Cancer is a class of diseases characterized by cells growth and multiplied  disorderly and uncontrollably. In advance stage, cancerous cell from the originated site can travel a distance away to infect other health tissue via lymph or blood circulation.

Most cancers process a high survival rate if they are diagnosed early. According to the Mayao Clinic, over 56 percent of people diagnosed with early-stage lung cancer live for at least five years after diagnosis. However, the five-year survival rate for people diagnosed with late-stage of invasive lung cancer  is 5 %.

According to the statistic of Canadian cancer provided by the government, in 2017, there were over 200,000 newly diagnosed cancer and 80,000 Canadian died from cancer. 1 in 2 Canadians will be diagnosed with cancer, and 1 in 4 will die from the disease, during their lifetime.

The exact cause of cancers are unknown. Researchers do not know why some people without gene mutation are susceptible to early onset of cancer while others do not

However, researchers do know that certain risk factors such as aging, tobacco, sun exposure, radiation exposure, chemicals and other substances, some viruses and bacteria, certain hormones, family history of cancer, alcohol, poor diet, physical inactivity are associated to gene change in initiation of cancer development.

Most cancers share the common symptoms of tiredness, unexplained weight loss, loss of appetite, fatigue. In advance stage, cancer patients may also experience additional common symptoms of dehydration, nausea and vomiting, constipation and persistent pain.

Andrographis parniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belongings to the family Acanthaceae, native to India and Sri Lanka.

The herb has been used in traditional Siddha and Ayurvedic to treat common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis,.... and chicken pox.


The Ingredients
Beside the main ingredient andrographolides, giving the plant a bitter taste, other ingredients includediterpene lactones, such as: neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.

With an aim to evaluate the effectiveness of Andro administered alone and combination with Cis against cancers, researchers at the University of Sydney, conducted an experiment, using ovarian A2780 and A2780(cisR) cancer cell lines.

Five different sequences of administration (Cis/Andro h): 0/0h, 4/0 h, 0/4 h, 24/0 h and 0/24 h. are examined for their anti-proliferative and apoptotic effects in tested cancer cell lines.

At the end of the experiment, researchers reported that

* Anti cancer activity in combined doses was lower in the resistant A2780(cisR) cell line than in the parent A2780 cell line compared to treatment of Cis alone.

* Andro alone was found to be three times more active in the A2780(cisR) cell line as compared to that in A2780 cell line.

* Cis and Andro administered using the sequences 0/4 h and 4/0 h produces a combined effect greater than the sum of their separate effects.

* The percentage of apoptotic cell death was found to be greater for the 0/4 h combination of Andro and Cis as compared to those values from single-drug treatments.

These results suggested, although herbal herbal Andrographis processes a strong anti cancer activity, its efficacy is lesser than those of combined dose of the herb + Cis.

On pulmonary cancer, using lung tumor mouse model induced by human vascular endothelial growth factor

A 165 (hVEGF-A165), researchers found that


* Andrographolide significantly reduces the expression of hVEGF-A165 compared with a mock group in the Clara cells of the lungs.

*  Andrographolide also decreased tumor formation by reducing vascular endothelial growth factor (VEGF) in formation of new blood vessel for cancer cells to grow, Epidermal Growth Factor Receptor (EGFR) in stimulation of cancer cells grow and division, Cyclin A, a protein in regulated cell division and Cyclin B, a protein which plays in integral role in cancer hyperplasia expression on the transcriptional and translational levels.

Dr. Tung YT, the lead author said, " Andrographolide treatment on the overexpression of VEGF can arrest the cell cycle, which induced pulmonary tumors in transgenic mice. In conclusion, the antiangiogenesis and chemotherapeutic potential of andrographolide may provide a cure for pulmonary tumors in the future".

Furthermore, Dr. Reddy's Laboratories in the classification of Andrographis anti Cancers effect showed that
* Andrographolide treatment inhibited the proliferation of different tumor cell lines, representing various types of cancers, in vitro

* Andrographolide exerts direct anticancer activity on cancer cells by cell-cycle arrest at G0/G1 phase through induction of cell-cycle inhibitory protein p27 in initiated cancer cell cycle division and decreased expression of cyclin-dependent kinase 4 (CDK4) in promoted cancer cell-cycle during G1/S transition.

* Andrographolide also enhanced the tumor necrosis factor-alpha production and CD marker expression, resulting in increased cytotoxic activity of lymphocytes against cancer cells.

Dr. after taking into acount of others co and confounders said, "These results suggest that andrographolide is an interesting pharmacophore with anticancer and immunomodulatory activities and hence has the potential for being developed as a cancer therapeutic agent".

The findings strongly suggested that Andrographis containing major bioactive compound Andrographolide, may be used alone or combination with other medicine for treatment of cancers.

However, further data collection on large example size and multi centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of Andrographis anti cancer possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

References
(1) Anti-proliferative and pro-apoptotic effects from sequenced combinations of andrographolide and cisplatin on ovarian cancer cell lines. by Yunos NM, Mutalip SS, Jauri MH, Yu JQ, Huq F.(PubMed)
(2) Therapeutic Potential of Andrographolide Isolated from the Leaves of Andrographis paniculata Nees for Treating Lung Adenocarcinomas. by Tung YT, Chen HL, Tsai HC, Yang SH, Chang YC, Chen CM.(PubMed)
(3) Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata. by Rajagopal S, Kumar RA, Deevi DS, Satyanarayana C, Rajagopalan R.(PubMed)
(4) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)

Green Tea, A Natural Alternative For Treatment of Chronic Back Pain

By Kyle J. Norton, Master of Nutrition

Green tea may have a therapeutic and positive effect in ameliorated symptoms and treatment of chronic back pain, some scientists suggested.

Chronic back pain is condition of back pain lasting more than 12 weeks.

It is also considered as musculo-skeletal disorders(MSDs) of the spine caused by various factors, including bone fractures, muscle or ligament injure, arthritis, herniated discs. aging,....

The traditional medicine suggested, acute back pain did not treat correctly during the time of onset may cause chronic back pain in the later days.

According to NIH, "chronic back pain can range in intensity from a dull, constant ache to a sudden, sharp sensation that leaves the person incapacitated. Pain can begin abruptly as a result of an accident or by lifting something heavy, or it can develop over time due to age-related changes of the spine".

The exact causes of back pain are debatable. However, researchers suggested that chronic back pain may also be initiated by some psychological risk factors such as fatigue, sleep disturbance, decreased appetite, and mood changes.

Truly, patients with chronic back pain may experience symptoms of limit movements, reduced back flexibility, strength, and stamina. In severe case, the pain can cause difficulty in carrying out important and enjoyable activities.

Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Application of biologically active polyphenol epigallocatechin 3-gallate (EGCG) demonstrated a significant effect in reduced back pain through stimulating anti inflammatory and anti-catabolic activity in patients with intervertebral disc (IVD) disease due to age-related changes in the adult disc in induction of back pain.

According to the study by the Institute for Biomechanics (D-HEST), ETH Zurich, ingestion of green tea EGCG on back pain patients, human IVD cells isolated from patients undergoing surgery due to degenerative disc disease (n = 34) and cultured in 2D or 3D indicated that the phytochemical inhibited levels of inflammatory response activated by IL-1β, a cytokine protein produced by macrophages, with function in contributed to the inflammatory pain and hypersensitivity in the site of infection, observed by the reverse transcription polymerase chain reaction (qRT-PCR), western blotting, enzyme-linked immunosorbent assay (ELISA), immunofluorescence and transcription factor assay.

Further more, application also displayed a strong effect in reduced expression of p38 mitogen-activated protein kinases in mediated inflammatory factors of IL-1β in responded to stress stimuli.

Also, according to the Institute for Biomechanics (D-HEST), in the investigation of the analgesic properties of EGCG, by the von Frey filament test in Sprague-Dawley rats (n = 60), green tea EGCG injection also significantly inhibited the expression of pro-inflammatory mediators as expressed in above and reduced matrix metalloproteinases which have been found to associate to pro-inflammatory cytokines, chemokines and other proteins in regulation of varied aspects of inflammation and immunity.

Moreover, in the radiculopathic pain component, researchers indicated that EGCG inhibits the inflammation in precipitated back pain through modulation of the activity of IRAK-1 in glucose metabolism and insulin sensitivity in skeletal muscle and p38, c-Jun N-terminal kinases (JNK) and nuclear factor NF-κB in responded to stress stimuli in mediated production of pain related pro inflammatory cytokines such as IL-1β.

Some researchers postulated that back pain may also be induced by muscle degeneration and impairment of nerve injury, leading to increased levels of reactive oxygen species in induced tissue apoptosis.

In crushing of the sciatic nerve induced back pain in tested animal, application of green tea EGCG improved motor function in the toe spread and foot positioning and gain in the percentage motor deficit.

More importantly, EGCG expressed a significant effect in recovery of sensory innervation in neuropathic pain-like syndrome and improvement of muscle tissues from injured limb with severe histopathological alterations at the end of week 3 post-surgery in treated animals.

According to the RT-PCR assay, EGCG treatment also normalizing the Bax/Bcl-2 ratio. Abnormal ratio of the Bax/Bcl-2 ratio has been found to associate in induction of nerve cell apoptosis as well as inhibited levels of p53 with function in regulated the cell death cycle at days 3 and 7 post-surgery.

These results demonstrated important effects of green tea EGCG in enhanced functional recovery, protected muscle fibers from cellular death, and improved morphological recovery in skeletal muscle after nerve injuries.

Taken together, green tea and its bioactive component epigallocatechin 3-gallate (EGCG) may be considered as functional food in reduced back pain caused by physical damage of the spine and injured nerve cells. Intake of green tea supplement should be taken exceptional care as some cases of liver acute toxicity have been reported in medical literature.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299

Sources
(1) Epigallocatechin 3-gallate suppresses interleukin-1β-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats by Krupkova O1, Sekiguchi M, Klasen J, Hausmann O, Konno S, Ferguson SJ, Wuertz-Kozak K.(PubMed)
(2) (-)-Epigallocatechin-3-gallate (EGCG) attenuates functional deficits and morphological alterations by diminishing apoptotic gene overexpression in skeletal muscles after sciatic nerve crush injury by Renno WM1, Al-Maghrebi M, Al-Banaw A.(PubMed)
(3) Caffeine and chronic low back pain by Currie SR1, Wilson KG, Gauthier ST.(PubMed)

Herbal Bearberry Leaf Normalizes High Blood Pressure in Vivo, Scientists Find

By Kyle J. Norton, Master of Nutrition

Herbal Barberry may be considered as a functional food and natural alternative in the prevention and treatment of high blood pressure quickly with no adverse effects, some scientists suggested.
High blood pressure or hypertension is a medical condition characterized by abnormally high blood pressure.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

The normal range of blood pressure is 120 over 80. The number in the top is systolic blood pressure, and the bottom is called the diastolic blood pressure.

Researchers do not know the exact causes of hypertension. However, researchers do know that certain preventable risk factors such as smoking, overweight or obese, physical inactivity,.... and excessive alcohol drinking are associated to increase risk hypertension.

Prolong period of raising the pressure of the hear can lead damage of the body in many ways.

Uncontrolled high blood pressure can lead to stroke heart disease by damaging and weakening your brain's blood vessels, a blood clot in the arteries.

An unhealthy diet high in salt, sugar, process products, genetic mutation, aging, family history,... and long-term stress also have a substantial impact on the onset of hypertension.

Dr. Kim EJ, the lead author in the study of the dietary effect in patients with borderline hypertension, suggested, " a short-term (12 weeks) lifestyle intervention had positive effects on blood pressure control and weight reduction in the subjects, but not on their blood levels of adipokines. It is interesting that the blood level of baseline leptin was negatively associated with the changes in blood pressure after this short-term intervention"(3).

The results showed that long-term dietary intervention should have a strong impact on keeping blood pressure in check.

Adipocytes found in the obese population may contribute to the high prevalence of hypertension.

Leptin, a chemical compound in the blood plays a critical role in regulation and arterial hypertension
Conventional blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they can induce serious side effects, including common gastrointestinal discomfort and psychological symptoms,

Lifelong intake of hypertension medicine can cause erectile dysfunction.

If you take the medicine in a long-term, please make sure you discuss the side effects with your doctor.

Bearberries are 3 species in the genus Arctostaphylos, belongings to the family Ericaceae, native to northern North America, Asia, and Europe.

The herbs have been used in traditional medicine as diuretic agents and to treat urinary problems, including bladder infections, kidney infection, kidney stone,.... and pelvic pain.


The Chemicals Ingredients
It contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides,..... and flavonoids.

With the aim to find the possible hypotensive activity of aqueous extract of Vaccinium Arctostaphylos leaves, the Shiraz University of Medical Sciences conducted an experiment of rats with two-kidney, one-clip hypertension.

All Rat were subjected to a sham operation of the placement of Plexiglass clip on left renal arteries.

After four weeks of surgery, renal artery clipped rats were either injected intravenously with different doses of the extract at 10, 25, or 75 mg/kg or normal saline.

The mean blood pressure and heart rate were measured before and 20, 40 and 60 minutes after vehicle or drug administration, researchers found that

* Group given normal saline has a significantly higher mean blood pressure, heart, and right kidney weights, lower left kidney weight and significantly indifferent heart rate.

* Treatment group with the injection of the extract at 75 mg/kg exerts a reduction of the mean blood pressure at 20, 40 and 60 minutes after administration without changing the heart rate.

* However, groups treated with doses of but 10 or 25 mg/kg show an insignificant change of mean blood pressure compared to group administrated with the extract at 75 mg/kg.

These results suggested that bearberry leaf extract has a potential in reduced blood pressure in a dose-depended manner.

Dr. Khalili A, the lead author at the final report, wrote, "... at a higher dose the extract did have hypotensive activity without changing the heart rate".

Truly, the Laboratoire de Pharmacognosie study of Arctostaphylos uva-ursi and hydroalcoholic extracts suggested that the test substances may process a pharmacological effect in reduced blood pressure through increasing urine flow and urinary sodium excretion in vitro.


Taking all together, herbal bearberry and its extract may be considered as functional food for treatment of high blood pressure.


However, further data collection on large example size and multi-centers studies performed with human consumption of the herbal leaf extract during the course of the disease will be necessary to complete the picture of bearberry hypotensive possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
1. The effects of aqueous extract of vaccinium arctostaphylos leaves on blood pressure in renal hypertensive rats. by Khalili A, Khosravi MB, Nekooeian AA. (PubMed)
2. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats by Beaux D, Fleurentin J, Mortier F.(PubMed)
(3) Effects of a 12-week lifestyle intervention on health outcome and serum adipokines in middle-aged Korean men with borderline high blood pressure by Kim EJ1, Cho SW, Kang JY, Choi TI, Park YK(PubMed)

Detoxification: Coffee, The Beverage Which Detoxes Our Body Against Chemo-Drugs, Radiation and Chemicals Toxins, Scientists Say

Kyle J. Norton (Master of Nutrition, All right reserved)
Coffee and coffee caffeine may have a profound and positive effect in detoxification of genotoxicity, caused by chemo-drugs, radiation and environment chemicals toxins, some scientists suggested.

Genotoxicity is activity of substances that can cause alternation of DNA of healthy cells to promote irregular cells growth. In other words, genotoxicity is an action that induces cancers.

Genotoxins are gene mutagens which have the property of genotoxicity,  including radiation and chemical toxins.

Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

In rat liver and primary hepatocytes, regular intake of coffee daily illustrated a enormous effect in cellular antioxidant defenses through regulating exhibited enzymes involved mRNA and protein expression.

The study also suggested that coffee and coffee caffeine through expression of detoxifying enzymes GSTs and AKR(in cellular detoxification) also demonstrated a significant activity in reduced risk of genotoxicity and cytotoxicity caused by injection of aflatoxin B1 (AFB1).

Dr. Cavin C, ther lead author said, " the coffee-mediated stimulation of the Nrf2-ARE pathway resulting in increased endogenous defense mechanisms against electrophilic but also oxidative insults further support that coffee may be associated with a protection against various types of chemical stresses".
(Please note that Nrf2-ARE pathway is an indicator and modulator of oxidative stress)

Other, in the evaluated L5178Y mouse lymphoma cell line to assess modulatory effects of coffee against genotoxicity induced by N-methyl-N-nitro-N-nitrosoguanidine (MNNG), researchers found that
* 3 doses of instant coffee caffeine injection displayed a decrease in genotoxicity following co-treatment of mouse lymphoma cells.

*. Coffee caffeine pre-treatment or co-treatment exhibited significant antigenotoxic effects against MNNG(an environmental carcinogen that causes DNA mutation) expression.

* Both caffeinated and decaffeinated instant coffee demonstrated a similar effect against genotoxicity in the experiment samples.

Dr. Abraham SK, the lead authors said, " Results from three or five independent experiments demonstrated significant protective effects of caffeinated instant coffee against MNNG-induced DNA damage in the comet assay, mutation at the Tk locus and chromosomal damage in the cytokinesis-block micronucleus test".

The Swiss Federal Institute of Technology (ETH), in the study of protective effects of coffee against somatic mutation and mitotic recombination induced by chemo drugs, cyclophosphamide (CPH)(, mitomycin C (MMC) and urethane (URE), using standard (ST) and high bioactivation (HB) crosses of the wing spot test in Drosophila melanogaster assays, suggested that in dose depending, coffee injection showed a strong effect in the genotoxicity of URE in the ST and the genetically susceptible HB cross as well as the genotoxicity caused by MMC application.

Dr. Abraham SK, the lead researcher said, "The magnitude of the protective effects of coffee against these three genotoxins was independent of the genotype of the larvae used for treatment, that is it was independent of the bioactivation capacity of these larvae".

The collective information showed a definitive support in used of coffee and coffee caffeine as functional food in reduced risk against genotoxic expression, including side effects of chemo medicine used in treatment of multi types of cancers.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science,  ISSN 0975-6299.

Sources
(1) Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver by Cavin C1, Marin-Kuan M, Langouët S, Bezençon C, Guignard G, Verguet C, Piguet D, Holzhäuser D, Cornaz R, Schilter B.(PubMed)
(2) Anti-genotoxicity of coffee against N-methyl-N-nitro-N-nitrosoguanidine in mouse lymphoma cells by Abraham SK1, Stopper H.(PubMed)
(3) Protection by coffee against somatic genotoxicity in Drosophila: role of bioactivation capacity by Abraham SK1, Graf U.(PubMed)

Infectious Diseases: Herbal Fennel, The Natural Alternative to Antibiotics With No Side Effects

By Kyle J. Norton, Master of Nutrition

Fennel may be the next natural antibiotics used for treatment of diseases caused bacterial infection with no side effects, some researchers suggested.

Although most micro bacteria are harmless, some are pathogenic.

Most common bacterial pathogens that cause human diseases are Staphylococcus aureus and group A β-hemolytic streptococci.

According to statistic provided by the World Health organization, approximately, 50,000 men, women and children are dying from infectious diseases every day world wide.

Some researchers suggested that over span decades or centuries, the epidemiological transition provides the central narrative of global health, including a reduction in mortality and creation of larger and older populations in which the main causes of illness are chronic infectious diseases.

Although, in comparison to the third world, the prevalence of infectious diseases in the UK has reduced dramatically over the last century, the rate of infectious diseases caused by pathogen still have a strong and negative impact in major health, social and economic issues.

Each year in UK, infectious diseases was found to cause 576 of days lost due to disability, out of 1000 population, according to statistic reported by Somerset Intelligence.

Most common symptoms of infectious diseases include fever, diarrhea, fatigue, tiredness, muscle aches,..... coughing. However, signs and symptoms may vary, depending on the pathogen, causing the infection.

Fennel is a species of Foeniculum Vulgare, belonging to the family Apiaceae (Umbelliferae), native to the shores of the Mediterranean. It is now widely cultivated all around the globe to use as food and herb.

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc

Chemical constituents(1)(2)
1. 1,3-benzenediol
2. 1-methoxycyclohexene
3. O-cymene
4. Sorbic acid,
5. 2-hydroxy-3-methyl-2-cyclopenten-1-one
6. Estragole
7. Limonene-10-ol
8. 3-methyl-2-cyclopenten-1-one
9. Linoleic acid
10. Oleic acid
11. Undecanal
12. 2,4-undecadienal
13. trans-Anethole
14. Fenchone
15. Limonene


In the study to examine 3 different essential oils from grown cultivars of Egyptian fennel, researchers found that according to chromatography/mass spectrometry analysis, all chemical compounds isolated from 3 essential oil processing a strong antioxidant activity in inhibited pathogenic bacteria including two species of fungi, two species of Gram negative and two species of Gram positive bacteria.

Further analysis also suggested that the efficacy of compounds isolated from essential oil from 3 species of fennel was attributed to its free radical scavenging, anti lipid peroxidation and metal chelating properties.

Additionally, in the observation of essential oils antioxidant activity from Foeniculum vulgare commercial aerial parts and fruits isolated by hydrodistillation, researchers at the Universidade do Algarve conducted an experiment, using different distillation times (30 min, 1 h, 2 h and 3 h), and analyzed by GC and GC-MS in isolated chemical compounds from obtained fennel essential oil.

According to the analysis of the agar diffusion method. trans-Anethole (31-36%), alpha-pinene (14-20%) and limonene (11-13%), the main components of the essentials oil isolated from F. vulgare dried aerial parts, and exerted a significant anti bacterial activity compared to methyl chavicol (= estragole) (79-88%) dominant in the fruit oils.

In DPPH method, according to measurement of  oxidative stress, plant essential oils showed better antioxidant activity compared to the fruits oils.

Dr, Miguel MG, the lead author wrote at the end of the experimental report, "None of the oils showed a hydroxyl radical scavenging capacity > 50%, but they showed an ability to inhibit 5-lipoxygenase. The essential oils showed a very low antimicrobial activity. In general, the essential oils isolated during 2 h were as effective, from the biological activity point of view, as those isolated during 3 h".

These results suggested that the effect of chemical compounds in inhibited pathogenic bacteria is isolated time dependable. Only those isolated less than 2 hours are process strong anti bacterial capability.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299

References
(1) Antimycobacterial activity of constituents from Foeniculum vulgare var. dulce grown in Mexico.by Esquivel-Ferriño PC1, Favela-Hernández JM, Garza-González E, Waksman N, Ríos MY, del Rayo Camacho-Corona M.(PubMed)
(2) Chemical composition, antimicrobial and antioxidant activities of essential oils from organically cultivated fennel cultivars by Shahat AA1, Ibrahim AY, Hendawy SF, Omer EA, Hammouda FM, Abdel-Rahman FH, Saleh MA.(PubMed)
(3) Foeniculum vulgare essential oils: chemical composition, antioxidant and antimicrobial activities by Miguel MG1, Cruz C, Faleiro L, Simões MT, Figueiredo AC, Barroso JG, Pedro LG.(PubMed)