* Caffeinated Coffee, The Liver Protective and Anti Non Alcoholic Liver Disease Beverage

By Kyle J. Norton

Habitual caffeinated coffee intake may have a potential of curing Non Alcoholic Liver Disease, some scientists found.

Non-alcohol fatty liver disease (NAFLD) is a chronic medical condition of fatty liver caused by excessive fat deposited (steatosis) in the liver other than over consumption of alcohol.

The disease is a common liver disorder found in most developed countries, probably due to over consumption of carbohydrates which are considered as a major stimulus for hepatic de novo lipogenesis (DNL), the esterification of plasma free fatty acids, such as American diet.

According to clinical assessment conducted by the joint study lead by the Global Clinical Research, " Hepatic de novo lipogenesis(DNL), the synthesis of new fatty acids from non-lipid sources, is thought to play a pivotal role in the development of NAFLD"(4).

In compared to lipids that were defined as soluble substances in organic solvents, including the various types of fatty acids, eicosanoids, fatty alcohols, fatty aldehydes, ...... and hydrocarbons, fatty acids from non-lipid sources are men make substances that do not rely on organic solvents, but use other chemicals to separate the lipids from the rest of the food, including butter milk fat, beef fat (tallow, suet), chicken fa,t cream pork fat, (lard),... and stick margarine

Dr. Paglialunga S. the lead author suggested as of today, there is no NAFLD-specific therapeutic agent available. However, pharmaceutical drugs aimed at reducing hepatic fat accretion may prove to be a powerful ally in the treatment and management of this disease(4).

Some researchers also said, a chronic metabolic derangement referred as steatosis are directly associated to patients with obesity and type 2 diabetes(4).

According to the statistic, approximately, 80 millions of US adults suffer from Non-alcoholic fatty liver disease (NAFLD) in which 30% to 40% of those patients show no visible signs and symptoms.

However, most patient with Non Alcoholic Liver Disease may experience signs and symptoms of abdominal swelling, enlarged blood vessels just beneath the skin's surface, spleen, red palms,.... and jaundice as a result of liver advanced scarring (steatohepatitis and cirrhosis).

If you have some of above symptoms, please see your doctor right the way to rule out the possibility.

Coffee, second to green tea, is a popular and social beverage all over the world, particular in the West, made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

According to a retrospective cross-sectional study on patients with non-alcoholic fatty liver disease (NAFLD), hepatitis C virus (HCV), and hepatitis B virus (HBV) infection to determine the effects of coffee intake on a non-invasive marker of liver fibrosis, coffee intake of 2 or more cups per day demonstrated a significant reduced liver symptom of stiffness, after adjustment for age, gender, smoking, alcohol consumption, in compared to other subgroups.

Additionally, in the review of epidemiological and clinical evidence by the Zhejiang University, researcher suggested coffee intake may have a profoundly reduced severity and risk of non-alcoholic fatty liver disease (NAFLD) prevalence.

In fact, the effect of coffee in attenuated risk of non-alcoholic fatty liver disease (NAFLD) incidence may be also involved other chemical constituents other than caffeine.

Dr. Chen S, the lead researchers suggested that said, "Several possible mechanisms underlying coffee's hepatoprotective effects in NAFLD include antioxidative, anti-inflammatory, and antifibrotic effects".


Interestingly, the review of literature published in database of Medline and Embase up to March 2015, showed that coffee and coffee caffeine intake have a strong impact in protect liver against complications of fibrosis incidence.

Information collected indicated that coffee and coffee caffeine intake have an enormous demonstration in ameliorated risk and symptoms of Non alcoholic liver disease, but some researchers suggested that other components may also play an important role in enhancement of these results.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Coffee Intake Is Associated with a Lower Liver Stiffness in Patients with Non-Alcoholic Fatty Liver Disease, Hepatitis C, and Hepatitis B by Hodge A1,2, Lim S3, Goh E4, Wong O5, Marsh P6, Knight V7, Sievert W8,9, de Courten B10.(PubMed)
(2) Coffee and non-alcoholic fatty liver disease: brewing evidence for hepatoprotection? by Chen S1, Teoh NC, Chitturi S, Farrell GC.(PubMed)
(3) Coffee and tea consumption in relation with non-alcoholic fatty liver and metabolic syndrome: A systematic review and meta-analysis of observational studies by Marventano S1, Salomone F2, Godos J3, Pluchinotta F4, Del Rio D5, Mistretta A1, Grosso G6.(PubMed)
(4) Clinical assessment of hepatic de novo lipogenesis in non-alcoholic fatty liver disease by Sabina Paglialunga1 and Clayton A. Dehn(PubMed)

* Chamomile Tea, The Herbal Tea That Works Better Than Sleeping Pills, With No Side Effects, Scientists Said

By Kyle J. Norton, Master of Nutrition

Intake of chamomile may have a strong and positive effect in prevented and treated insomnia, some scientists suggested.

Insomnia is a chronic sleep disorder characterized by difficulty of falling sleep and/or staying asleep. The condition affects most of the population of older adults due to hormones change that are associated to aging.

Most adults have experienced insomnia sometimes in their life. According to statistic, more than 30% of the population suffers from insomnia, one in three people suffer from some form of insomnia during their lifetime and women suffer from insomnia more often than men.

Some researchers suggested that psychiatric and medical conditions, unhealthy sleep habits,and in healthy diet and life style, particularly in use of substances, and/or certain biological factors are major causes of insomnia onset.

Some women in certain stages of menstrual  cycle also suffer from this type of sleep disorder, due to the body inability to cope with sudden change of hormone production. Needless to say,  insomnia that is caused by menstrual pain. According to the National Sleep Foundation poll, 33% of women said, their sleep is disturbed during their menstrual cycles.

In Australia, according to statistic produced by Virtual Medical Center, "Almost 90% of Australians suffer from a sleeping disorder, with 30% experiencing a severe sleeping disorder" and  "There are over 70 different defined sleep disorders which result in reduced sleep quantity or reduced sleep quality"(4).

Poor sleep quality in patients who suffer from insomnia may induce symptoms of fatigue, irritability, decreased memory and concentration,..... and malaise.

These results truly have a strongly negative impact on quality of life and work life, resulting in decreasing productivity and increasing absenteeism.

Use of sleep pill to treat insomnia may be effective, however, according to the Additive Center, "The dangerous effects of sleep medications range from seizures to depressed breathing. Some people also experience allergic reactions from sleeping pills that can cause difficulty breathing, chest pain, nausea and swelling" and "Though rare, people who use sleeping pills may even develop parasomnias. Parasomnias are defined as sleep disorders that include behaviors like sleep-walking, sleep-eating, sleep-sex, sleep-driving and other potentially dangerous sleep-related activities"(5).

Chamomile is also known as camomile, common name of many species daisy-like plants in the family Asteraceae.

The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas,..... and bloating in the intestine.

Ingredients
Guaianolides matricarin and achillin, acetoxyachillin and leucodin (= desacetoxymatricarin), corresponding C-11 stereoisomers(a),(Z)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (cis-GMCA), chlorogenic acid, (E)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (trans-GMCA), quercetagetin-7-O-β-d-glucopyranoside, luteolin-7-O-β-d-glucoside, apigenin-7-O-β-d-glucoside, chamaemeloside, apigenin 7-O-(6″-O-acetyl-β-d-glucopyranoside), apigenin] and one polyacetylene (tonghaosu)(b).

Chamomile, is one of most popular herb used for sleep disorders in herbal medicine. 

According to the Dr. Srivastava JK and research team at the Case Western Reserve University, in the investigation of The dried flowers of chamomile containing many terpenoids and flavonoids that may contribute to its medicinal properties, found that, injection in form of herbal tea, consumed more than one million cups per day worldwide, may have a significant impact in treatment of insomnia(1).

In the concerns of chamomile's (Matricaria recutita) efficacy and safety for treating chronic primary insomnia, scientists at the University of Michigan conducted an experiment of 34 patients aged 18-65 years with DSM-IV primary insomnia for ≥ 6-months, showed that application of 270 mg of chamomile twice daily or placebo for 28-days exerts a modest benefits of daytime functioning and mixed benefits on sleep diary(2).

Dr. Zick SM, the lead author at the end of the evaluation, said, "Chamomile did show modest advantage on daytime functioning, although these did not reach statistical significance. Effect sizes were generally small to moderate (Cohen's d ≤ 0.20 to < 0.60) with sleep latency, night time awakenings, and Fatigue Severity Scale (FSS), having moderate effect sizes in favor of chamomile"(2).

  The efficacy of chamomile in treatment of insomnia may also be attributed to the anxiolytic or sedative properties in improvement of sleep, according to the study of traditionally endowed with anxiolytic or sedative properties,(3).

However, Dr. Wheatley D suggested, " it's slow onset of effect (2-3 weeks) renders it unsuitable for short-term use (i.e. 'jet-lag'), but it does have profound beneficial effects on sleep architecture (augments deep sleep) that may make it particularly suitable for long-term use and for the elderly"(3).

The findings suggested that chamomile may be used as functional food to improve insomnia due to the procession of anxiolytic or sedative properties.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
References
(a) Guaianolides and volatile compounds in chamomile tea by Tschiggerl C1, Bucar F.(PubMed)
(b) Quantitative determination of phenolic compounds by UHPLC-UV-MS and use of partial least-square discriminant analysis to differentiate chemo-types of Chamomile/Chrysanthemum flower heads by Avula B1, Wang YH, Wang M, Avonto C, Zhao J, Smillie TJ, Rua D, Khan IA.(PubMed)
(1a) Anxiety disorder(Canadian mental health association)
(1) Chamomile: A herbal medicine of the past with bright future by Srivastava JK1, Shankar E, Gupta S.(PubMed)
(2) Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study by Zick SM1, Wright BD, Sen A, Arnedt JT.(PubMed)
(3) Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. by Wheatley D.(PubMed)
(4) Insomnia by Virtual Medical Center
(5) Signs of Sleeping Pill Abuse by the Additive Center

* Avocado, The Prominent Fruit That Arrests Prostate Cancer Cells Cycle Division

By Kyle J. Norton, Master of Nutrition

Scientists may have  found a popular fruit that has a profound and positive effect in prevention and treatment of prostate cancer, some studies suggested.

Prostate cancer is a medical and chronic disease characterized by cells growth disorderly and uncontrollably in the tissue of prostate gland. At the later stage, cancerous cells may travel a distance away from the prostate gland to infect other healthy tissue and organs.

According to statistic in US, 1 in 9 men will be diagnosed with prostate cancer during his lifetime. Approximately, 6 cases out of 10 diagnosed with the condition are men aged 65 or older.

In 2017, 21,300 men in Canada were diagnosed with prostate cancer which represents 21% of all new cancer cases in men. And 4,100 men died from the disease(4).

Although Inherited mutations such as BRCA1 and BRCA2 that cause abnormal cell growth in the prostate gland are considered a major cause of prostate cancer, Acquired gene mutations such as over production of androgens (male hormones) gene that promote prostate cell growth also contribute to prostate cancer risk in some men.

However, over years of studies also suggested that  increases of age, ethnic group, family history, obesity, environment chemical,.... and unhealthy diet are also have a strong implication in induction to the onset of prostate cancer. 

Due to the slow progression of the disease, most patients do not experience any symptoms until the advance stage. Most common symptoms including blood in urine (hematuria), burning or pain during urination, difficulty urinating, decreased flow or velocity of urine stream, ......more frequent urges to urinate at night. 

In some cases, patients may also be loss of bladder control. 

If you experience some of above symptoms, please check with your doctor immediately to rule out the possibility.

Avocados are a commercially valuable fruit cultivated in tropical climates throughout the world.

The fruit has a green-skinned, pear-shaped fruit that ripens after harvesting, native to the Caribbean, Mexico, South America and Central America, belonging to the flowering plant family Lauraceae.


Chemical constituents
The fruit contains campesterol, high amounts of β-sitosterol; fatty acids (approximately 60% monounsaturated, 20% saturated, and 20% unsaturated); high amounts of glutathione (27.7 mg/100 g); approximately 2% protein; 6–9% carbohydrates and sugars (glucose, fructose, d-mannoheptulose, a taloheptulose, and an alloheptulose); two bitter substances (1-acetoxy-2,4-dihydroxyheptadeca-16-ene and 1,2,4-trihydroxyheptadeca-16-ene); carnitine; proanthocyanidins; persenones A and B(a).

According to the Case-control study of 209 men 40-80 years old with newly diagnosed, histologically confirmed prostate cancer and 226 cancer-free men attending the same urology clinics conducted by the University of the West Indie, intake of dietary MUFA from whole fruit of avocado are associated to reduced risk and treatment of prostate cancer(1).

Dr. Jackson MD, the lead scientist said, "Whole-blood and dietary MUFA reduced the risk of prostate cancer. The association may be related to avocado intakes. High blood linolenic acid was directly related to prostate cancer" and " Dietary intakes of other fats were not associated with PCa"(1).

The University of California study showed that the anti prostate cancer effects of avocado are not attributed to a single ingredient such as carotenoids (zeaxanthin, alpha-carotene, and beta-carotene), lutein but the interaction of all ingredients in the whole fruit in combination with other det-derived phytochemicals(2).

The study suggested, intake of avocado stimulated the increase production of increase in p27 protein which involves function as tumor suppressor in controlling the cell cycle progression, in incubated PC-3 cells(2)

Avocado induced PC- 3 cancer cell death through cells apoptosis through G(2)/M cell cycle arrest the study continued(2).

In the evaluation of the anti cancers effect of avocado conducted by the Purdue University study also showed a positive effect of the whole fruit in inhibition of six human tumor cell lines in culture, including human prostate adenocarcinoma (PC-3) cells(3).

The newly isolated Compounds 3 form of avocado containing g 1,2,4-triol moiety and a long aliphatic chain that terminates as either an alkane, alkene, or alkyne, respectively, exerted a strongest activity against PC-3 in comparable to adriamycin, an anti-cancer conventional medicine(3).

Furthermore, when tested against yellow fever mosquito larva, the 3 form avocado also was more effective than rotenone, a natural botanical insecticide(3).

Therefore, men who are at high risk of prostate cancer may want to add a portion of avocado into their daily diet for preventive measure.

Taken altogether, avocado with abundant carotenoids (zeaxanthin, alpha-carotene, and beta-carotene), lutein may be considered as functional food for prevention and treatment of prostate cancer.

However, additional large sample size and multi center clinical trials with human consumption during the course of the disease are necessary to re confirm avocado anti prostate cancer possibility.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
References
(a) Leung's Encyclopedia of Natural Ingredients:Chemical Composition of Avocado
(1) Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica by Jackson MD1, Walker SP, Simpson-Smith CM, Lindsay CM, Smith G, McFarlane-Anderson N, Bennett FI, Coard KC, Aiken WD, Tulloch T, Paul TJ, Wan RL.(PubMed)
(2) Inhibition of prostate cancer cell growth by an avocado extract: role of lipid-soluble bioactive substances. by Lu QY1, Arteaga JR, Zhang Q, Huerta S, Go VL, Heber D.(PubMed)
(3) Cytotoxic and insecticidal constituents of the unripe fruit of Perseaamericana by Oberlies NH1, Rogers LL, Martin JM, McLaughlin JL.(PubMed)
(4) Prostate cancer statistics, Canadian Cancer Society
12. Avocado and Skin health
13. Avocado and Cadiovascular diseases

* Green Tea, The Beverage Inhibits A Cluster Conditions That Cause Metabolic Syndrome, Scientists Reveal

Kyle J. Norton, Master of Nutrition


A recent study conducted by some renowned institutes suggested that regular drinking of green tea may inhbit the early onset of metabolic syndrome.

Metabolic syndrome is a cluster conditions associated to increase risk of heart disease, stroke and diabetes, including abnormal high blood pressure, high blood sugar and cholesterol together with excess body fat around the waist.

People with 3 of above medical conditions are considered to have metabolic syndrome.

According to statistic, approximately, 25% of US adult population have metabolic syndrome.

Some researchers suggested that the syndrome is also associated to condition of obesity as they share the similar component of insulin resistance.

Truly, the syndrome is not caused by single condition but associated to a collection of risk factors,
including  increases with age. race, obesity, diabetes and other diseases (cardiovascular disease, nonalcoholic fatty liver disease or polycystic ovary syndrome).

According to the joint study lead by the University of South Florida Morsani College of Medicine in investigated the prevalence of metabolic syndrome (MetS) and its components among U.S. adults, using the National Health and Nutrition Examination Survey 2007-2014 data suggested, ".... from 2007 to 2014, the prevalence of MetS remained stable in all sex, age, and race/ethnicity groups. Among the components of MetS, the prevalence of hypertriglyceridemia and fasting hyperglycemia decreased". and "The prevalence of elevated blood pressure and low high-density lipoprotein cholesterol level remained stable"(4).

Further analysis of the data, scientists found that the prevalence of abdominal obesity continues to increase in women, that can have a strong and lifelong impact in induction of higher risk of metabolic syndrome.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

In a cross-sectional population-based survey including 8,821 adults (51.4% female) conducted in Krakow, Poland., both coffee and tea drinkers showed a negatively associated with MetS (OR 0.75, 95% CI 0.66, 0.86 and OR 0.79, 95% CI 0.67, 0.92, respectively).

The study also found that high tea consumers had lower BMI, waist circumference, but moderated decreased diastolic blood pressure, as well as negatively correlated central obesity and fasting plasma glucose in women, but not in men, in compared low drinker,


Furthermore, in the study including 8821 adults (51.4 % female), using food frequency questionnaires and matching food consumption data with the Phenol-Explorer database.conducted in Kraków, Poland, dietary polyphenol intake,  a major compound found in green tea  was associated inversely to the development of MetS (OR 0.80; 95 % CI 0.64, 0.98 and OR 0.70; 95 % CI 0.56, 0.86 for both men and women, respectively) in the highest quartile.

Dietary polyphenols in high quality also showed a negative association of WC, blood pressure, high lipoprotein cholesterol, and triglycerides in women, and fasting plasma glucose in both gender..

Dr. Grosso G, the lead author said, "(Depending to types of polyphenols) phenolic acids and stilbenes were significantly associated with MetS; lignans and stilbenes with WC; phenolic acids with blood pressure and triglycerides; and flavonoids with fasting plasma glucose" and " Among specific subclasses of polyphenols, hydroxycinnamic acids, flavanols, and dihydrochalcones had the most relevant role."

In support the role of polyphenol for treatment of Metabolic syndrome,  a study of total of 2725 participants free of hypertension at baseline tested for blood pressure or taking hypertensive medication within the last 2 weeks at 2-4-year follow-up visit was conducted by the Integrated Cancer Registry of Catania-Messina-Siracusa-Enna.

The final results showed that diet of highest quartile of total polyphenol intake was associated with 31% decreased risk of hypertension compared with the lowest intake (OR 0.69, 95% CI 0.48, 0.98) in women with no significant association in men.

The study also stated that most influential phytochemicals in reduced risk and treatment of metabolic syndrome ingredients are phenolic acids, hydroxycynnamic acids as they showed a independently associated to lower odds of hypertension (OR 0.66, 95% CI 0.47, 0.93) in comparison to others.


Taking together, green tea with major chemical compounds of polyphenol may be used as functional foods in inhibited a cluster of conditions which associated to the onset of metabolic syndrome.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Association of daily coffee and tea consumption and metabolic syndrome: results from the Polish arm of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Topor-Mądry R3, Pikhart H4, Szafraniec K3, Pająk A3.(PubMed)
(2) Dietary polyphenols are inversely associated with metabolic syndrome in Polish adults of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Stefler D4, Bobak M4, Pająk A3.(PubMed)
(3) Dietary polyphenol intake and risk of hypertension in the Polish arm of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Kozela M3, Stefler D4, Bobak M4, Pajak A3.(PubMed)
(4) Trends in the prevalence of metabolic syndrome and its components in the United States 2007-2014 by Shin D1, Kongpakpaisarn K2, Bohra C(PubMed)

Herbal Catnip, The Herbal Medicine and Plant Which Inhibits Inflammatory Diseases

By Kyle J. Norton, Master of Nutrition

Scientists may have found a herbal medicine that processes anti-inflammatory activity to protect our body from overexpression of pro-inflammatory cytokines in causing damage to healthy cells in the infectious site without reducing inflammatory cytokine activities.

Inflammation is a natural reaction of the immune system which initial protein signaling in stimulated production of inflammatory expression against foreign organisms invasion.

However, under the infectious condition, systematic inflammatory response in some cases may over overact, leading to overproduction of pro-inflammatory cytokines such as TNF alpha,.... and  

Interleukins (IL) 1 and 6. which are a group of cytokines expressed by white blood cells of the immune system.

The Encyclopaedia Britannica wrote, "Like other cytokines, interleukins are not stored within cells but are instead secreted rapidly, and briefly, in response to a stimulus, such as an infectious agent. Once an interleukin has been produced, it travels to its target cell and binds to it via a receptor molecule on the cell’s surface" and  "This interaction triggers a cascade of signals within the target cell that ultimately alter the cell’s behavior".

Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia. 

The herb has been used in herbal medicine as an insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritation stimulates sweating, promote menstruation, etc..

Ingredients
Besides the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc.

In chronic related inflammation disease induced to 24 male Wister rats weighing 225 ± 25 gm, essential oil of catnip at the doses of 50 mg/kg, 100 mg/kg and 200 mg/kg researchers found that administered doses intraperitoneally exert significant effects in reduced paw edema by alleviating symptoms of both the acute and chronic forms of nociception, through its anti-inflammatory effect(1).

Dr. Ali T, the lead scientists at the Bangabandhu Sheikh Mujib Medical University, said, " NP 200 mg/kg reduced the pain sensation in the tail flick (p <0.01) and formalin test (p <0.001 in both phases). In paw edema test, NP 100 and 200 mg/kg significantly reduced the inflammation (p <0.01 and p <0.05)"(1).

The efficacy of catnip in inhibited chronic inflammation of experimental rats was attributed to chemical constituents 4aα,7α,7aβ-nepetalactone and 1,8-cineole that form major parts in phytochemicals of the herb.

The Tarbiat Modares University study also showed that Nepeta crispa essential oil enhances anti-inflammatory effects in the formalin-induced paw inflammation model and significantly reduced the paw edema(2).

More precisely, the essential oil injection ameliorated acute pain in animal models, including the tail-flick (p < 0.001) in the first phase of the formalin test (p < 0.01) through the production of analgesia(2).

In the late phase of the formalin test, the essential oil significantly reduced the pain-induced behavior against chronic pain(2).

Furthermore, in the study of extracts and isolated compounds tested against calcineurin, scientists showed that herbal catnip has a direct interaction with calcineurin through anti-inflammatory activity via modulation of T-cell in the mediation of inflammation(3).

Dr. Prescott TA and the research team at the Royal Botanic Gardens suggested, " Calcineurin inhibition should be considered as a potential mode of action when investigating the immunomodulatory activity of caffeoyl phenyle anoid glycoside containing plants"(3).

The findings suggested that herbal catnip may be considered as a functional food for treatment of acute and chronic inflammation without reducing the function of the immune system in protected our body against infection.

However, large sample size and multi-center clinical studies during the course of human consumption are necessary to reaffirm the catnip anti-inflammatory possibility.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Evaluation of the antinociceptive and anti-inflammatory effects of essential oil of Nepeta pogonosperma Jamzad et Assadi in rats by Ali T, Javan M, Sonboli A, Semnanian S.(PubMed)
(2) Antinociceptive and anti-inflammatory activities of the essential oil of Nepeta crispa Willd. in experimental rat models by Ali T, Javan M, Sonboli A, Semnanian S.(PubMed)
(3) Direct inhibition of calcineurin by caffeoyl phenylethanoid glycosides from Teucrium chamaedrys and Nepeta cataria by Prescott TA, Veitch NC, Simmonds MS.(PubMed)

(4) Interleukin PROTEIN by Encyclopaedia Britannica

How to Protect Your Joints (Articulations) Before and After 60

By Kyle J. Norton, Master of Nutrition

Scientists may have found a natural herb, namely Cat's claw in suppressing the onset of osteoarthritis without inducing any adverse effects, some studies suggested

Osteoarthritis is a group of diseases involved progressive degeneration of joints, including articular cartilage and subchondral bone.

According to statistic, osteoarthritis(OA) is one of the most common forms of arthritis disorder, affecting adults 60 years of age or older in the United States.

Approximately, over 25 million of US population who are adults 60 years of age or older are infected by symptomatic knee OA, including  10% of men and 13% of women.

However, according to University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in the knee, hip and hand joints.

Conventional medicine, today in the management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, nonpharmacological, and surgical treatments without mentioning how to cure the disease.

 There is evidence suggested that the disease is associated with the inflammation, breakdown, and eventual loss of cartilage in the joints. But what causes the chronic inflammatory of osteoarthritis is debatable?

Some researchers suggested that the process of wear and repair, nutrient deficiency,......and overload and damage of cartilage due to aging or damage are the possible actually cause of osteoarthritis.

The severity symptoms of osteoarthritis, according to experts include pain in joints of the hand, knee and hip and spine. If you experience the above symptoms, you may already have osteoarthritis.

.Cat's claw found in in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.

The specific herbal medicine has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..

Chemical constituents
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.

In the study to understand the effect of Cat's claw isolated active compounds against the pivotal molecular targets involved in inflammation and the joint destruction process and in summarized their 's claw toxicities and efficacy, researchers at the Case Western Reserve University, showed that application of herbal Cat's claw exerts a positive effect in alleviation pain with no adverse effect(1).

Dr. Akhtar N, the lead author after taking account of other co and confounders said, " (Although) Limited in vitro and in vivo evidence is available for cat's claw and Indian olibanum,... There is strong clinical evidence of the effectiveness of devil's claw in pain reduction" and " No serious side effects have been reported for any..... herbs" (1).

According to the study of "Devil's claw extract as an example of the effectiveness of herbal analgesics", Doloteffin (extraction solvent water) a botany herbal preparation included extracted with 60% ethanol of Cat's claw have a proven effectiveness similar to those of conventional painkiller or synthetic analgesics for treatment painful lower back or arthritic pain(2)..

Dr. Chrubasik S. at Institut für Rechtsmedizin der Universität Freiburg, said, " From an evidence-based view, extract with at least 50 mg harpagoside in the daily dose should be recommended for the treatment of pain" and "Treatment with devil's claw extract is associated with a lower risk of adverse events than treatment with synthetic analgesics, and may contribute in the majority of patients to the relief of pain"(2).

This effectiveness may coincide with the use of the herb in herbal medicine for thousands of year in treating disorders such as arthritis, gastritis, and osteoarthritis(3).

Truly, The mechanisms of cat's claw in the treatment of osteoarthritis were attributed to the antioxidants and its inhibition of TNF-alpha.

Tumor necrosis factor α is a cell signaling protein (cytokine) involved systemic inflammation that protects our body against foreign organism infection in acute phase reaction.

Unfortunately, the study in reviews the database by the University of Southampton, raised the question of the methodological quality of the existing clinical trials and suggested that clinical evidence to date cannot provide a definitive answer to the two questions posed, although these trials may provide certain supports for the effectiveness of the herb(4).
* Does it work?
* And (2) is it safe?

Taking all together, Cat's claw may have a profound and substantial effect similar to those of conventional medicine such as acetaminophen (Tylenol) and nonsteroidal anti-inflammatory drugs (NSAIDs). Aspirin, naproxen (Aleve), and ibuprofen in ameliorated osteoarthritis pain with little or no side effects(3).

However, intake of Cat's claw supplement only is prescribed by herbalists as an overdose may cause acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Current nutraceuticals in the management of osteoarthritis: a review by Akhtar N1, Haqqi TM. (PubMed)
(2) [Devil's claw extract as an example of the effectiveness of herbal analgesics].[Article in German]
by Chrubasik S.(PubMed)
(3) Cat's claw: an Amazonian vine decreases inflammation in osteoarthritis by Hardin SR.(PubMed)
(4) Devil's Claw (Harpagophytum procumbens) as a treatment for osteoarthritis: a review of efficacy and safety by Brien S1, Lewith GT, McGregor G.(PubMed)
(5) Osteoarthritis by Kyle J. Norton

Unripe Papaya Whole Food Which Averts The Onset of Diabetes, Scientists Found

By Kyle J. Norton

Papaya may be used as a functional food to inhibit early onset and treatment of diabetes, some scientists suggested.

Diabetes is a medical and chronic condition characterized by abnormally high levels of sugar (glucose) in the blood caused by pancreas inability in produced insulin.

In other words, diabetes is a result of absence or insufficient production of insulin by the pancreas. The condition is also caused by the inability of the body to properly use of insulin, leading to insulin resistance.

According to the statistic produced by the Canadian Diabetes Association, approximately, 17%
of Canadian, over 12 years of age are diagnosed with diabetes.

Interestingly, diabetes affects both genders up to age 64. The prevalence does not increase significantly for those aged 65 and older.

Unlike type 1 diabetes which is caused by the immune system attacking the cells in the pancreas that make insulin, leading to the body without enough insulin to function normally, type 2 diabetes is caused by unhealthy diet and lifestyle.

Obesity and increasing age are 2 of many risk factors that can elevate the risk of type 2 diabetes. 

Symptoms of type 1 and 2 diabetes, according to Medicine Net include increased urine output, excessive thirst, weight loss, hunger, fatigue, skin problems slow-healing wounds, yeast infections,..... and tingling or numbness in the feet or toes(6).

If you experience some of the above symptoms, please see a doctor to rule out the possibility.

Papaya is a species of Carica Papaya, belongings to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries


Chemical constituents
Alkaloids, Cardenolides, Anthraquinones, Saponins, Tannin, phenol, flavonoid, anthocyanin, Benzyl glucosinolate, benzylisothiocyanate, 5-(Hydroxymethyl)-2-furancarboxaldehyde, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and 1,3-dihydroxy-2-propanone, etc.(a).


Water extract from papaya isolated from unripe pawpaw (Carica papaya Linn) fruit, exerted a significant effect in inhibition of enzymes, α-amylase and α-glucosidase that linked to type 2 diabetes, in sodium nitroprusside (SNP)-induced lipid peroxidation mice model and a dose-dependent manner(1).

Combination of the flesh, seed, and peel in equal amounts produced the highest inhibitory effect on α-amylase and α-glucosidase activities compared to other preparations.

Dr. Oboh G, the lead authors in the study said, "Strong inhibitory activities of the unripe pawpaw fruit against key enzymes linked to type 2 diabetes and SNP-induced lipid peroxidation in rat pancreas could be part of the mechanism by which unripe pawpaw is used in the management/prevention of diabetes mellitus in folk medicine"(1).

Truly, in the preparation of individual aqueous extract of the unripe pawpaw fruit parts; peel (PG), seed (SG), flesh (FG), flesh with peel (FPG) and a combination of equal amount of all parts (CG), the Federal University of Technology at the end of experiment indicated that on Fe²⁺-induced lipid peroxidation in rat pancreas, application of the prepared extracts phenolic compounds inhibited oxidative stress through their antioxidant activities(2).

According to Universidad Juárez Autónoma de Tabasco (UJAT), unripe papaya preparations not only exert hypoglycemic effects in both animals and humans studies but also help islet regeneration,   preservation of cell size and prevented hepatocyte disruption(3).

In fact, the aqueous extract of Carica papaya also significantly decreased blood glucose levels in diabetic rats and decreased cholesterol, triacylglycerol, and amino-transferases blood levels without changing the levels of plasma insulin levels in diabetic rats(4).

 In short-term supplementation of a fermented papaya, showed to exhibit its effect in the management of diabetes and for those at risk for cardiovascular disease, neurological disease and other conditions worsened by overt inflammation and oxidative stress(5).

These findings suggested that all parts of unripe papaya have a strong and profound effect in inhibition of diabetic onset and treatment of type 2 diabetes.

However, a large sample size and multi-center clinical trial on human consumption on the course of the disease onset are necessary to confirm the unripe papaya anti-diabetes possibility.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(a) Chemical composition and bioactivity of dried fruits and honey of Ficus carica cultivars Dottato, San Francesco and Citrullara by Loizzo MR1, Bonesi M, Pugliese A, Menichini F, Tundis R.(PubMed)
(1) Inhibition of key enzymes linked to type 2 diabetes and sodium nitroprusside-induced lipid peroxidation in rat pancreas by water-extractable phytochemicals from unripe pawpaw fruit (Carica papaya). by Oboh G, Olabiyi AA, Akinyemi AJ, Ademiluyi AO.(PubMed)
(2) Inhibitory effect of aqueous extract of different parts of unripe pawpaw (Carica papaya) fruit on Fe²⁺-induced oxidative stress in rat pancreas in vitro by Oboh G1, Olabiyi AA, Akinyemi AJ.(PubMed)
(3) Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats by Juárez-Rojop IE1, Díaz-Zagoya JC, Ble-Castillo JL, Miranda-Osorio PH, Castell-Rodríguez AE, Tovilla-Zárate CA, Rodríguez-Hernández A, Aguilar-Mariscal H, Ramón-Frías T, Bermúdez-Ocaña DY.(PubMed)
(4) Antihyperglycemic and hypolipidemic activities of aqueous extract of Carica papaya Linn. leaves in alloxan-induced diabetic rats by Maniyar Y1, Bhixavatimath P(PubMed)
(5) Effects of a short term supplementation of a fermented papayapreparation on biomarkers of diabetes mellitus in a randomized Mauritian population by Somanah J1, Aruoma OI, Gunness TK, Kowelssur S, Dambala V, Murad F, Googoolye K, Daus D, Indelicato J, Bourdon E, Bahorun T.(PubMed)
(6) Diabetes Symptoms, (Type 1 and Type 2) by Medicine Net