The Veggie and Plant Suppressed Oxidative Stress That Causes Atherosclerosis, Cancers, Diabetes, Rheumatoid Arthritis, Post-ischemic Perfusion Injury, Myocardial Infarction, Cardiovascular Diseases,... and Stroke

Kyle J. Norton

Carrots may have a profound and positive effect in reduced oxidative stress in the induction of related chronic diseases, including atherosclerosis, cancers, diabetes, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases,... and stroke, some scientists suggested.

Oxidative stress is the indication of overexpression free radicals in the body due to depletion of antioxidants produced by the host tissue.

According to the Department of Biotechnology, M. J. College, "Overproduction of free radicals can cause oxidative damage to biomolecules, (lipids, proteins, DNA), eventually leading to many chronic diseases".

The studies of carrots in reduced overproduction of reactive oxygen species in facilitated oxidative stress were carried out by several respectable institutes and the results were published online medical literature.

Carrot, a root vegetable with an orange color is a sub species of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.


In the investigation of the relation of dietary supplementation with lycopene (LYC), a major active biochemical compound found in carrot, on age-induced cognitive impairment, and the potential underlying mechanisms, using the behavioral tests, researchers at Northwest A&F University, researchers found that chronic injection of LYC exerts a potential effect in alleviated age-associated memory loss and cognitive defects through several mechanisms

Application of lycopene improved antioxidant produced by the host body in countering to the over expression of free radicals, including glutathione, catalase, and superoxide dismutase activities and the levels of antioxidant-enzyme.

Treatment of the phytochemical displayed a strong activity in reversed age-associated neuronal damage and synaptic dysfunctions in the brain, through inhibited the levels of malondialdehyde (MDA) levels in associated to oxidative stress.

Malondialdehyde (MDA) levels is considered as oxidative maker usedthe in treatment of cancers and other oxidative related diseases.

Interestingly, researchers also indicated that chronic injection of bioactive lycopene lower the levels of the accumulation of Aβ1-42 in the brains in aged CD-1 mice model.

Evidences findings suggested that Aβ-induced oxidative stress may place the majority of the causative effect of increased cellular oxidative stress upon oligomeric Aβ(1–42).

Further more, LYC supplementation also significantly reduced age-associated neuroinflammation caused by over expression of free radicals in activation of proinflammatory cytokines by inhibiting microgliosis (Iba-1) in response to damage to the central nervous system (CNS) and related inflammatory chemicals mediators.

These results overwhelmingly suggested that lycopene injection processes a strong effect in reduced risk  and treatment of diseases associated to over production of ROS, through re-balancing the ratio of antioxidant and free redials in the host body.

Moreover, in d-galactose induced CD-1 male mice cognitive impairments, chronic LYC supplementation (50 mg/kg bodyweight per day) demonstrated a significant activity in inhibition of oxidative stress-induced cognitive defects.

Injection of lycopene also ameliorated histopathological damage and restored brain derived neurotrophic factor (BDNF) levels in the hippocampus of mice. This findings reaffirms the conclusion of the Northwest A&F University study.

LYC treatment an in animal model,  also increased antioxidant of the host by activating the mRNA expressions of antioxidant enzymes HO-1 and NQO-1, and inhibited the oxidative stress the in induction of inflammatory cytokines IL-1β and TNF-α in host hippocampus.

More precisely, LYC attenuated neuronal oxidative damage through activation of Nrf2 signaling in increased levels of anti inflammatory mytokines and inactivation of NF-κB translocation in signalling pro inflammatory expression.

Dr. Zhao B, the lead scientist, after taking into account of co and confounders said, " LYC could ameliorate oxidative stress induced neuroinflammation and cognitive impairment possibly via mediating Nrf2/NF-κB transcriptional pathway".

The findings indicated that carrot with major active compound lycopene may be considered as function foods in prevention and treatment of oxidative related diseases by restoring the ratio of reactive oxygen species and levels of antioxidant in the body.

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Author Biography

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Lycopene Supplementation Attenuates Oxidative Stress, Neuroinflammation, and Cognitive Impairment in Aged CD-1 Mice by Zhao B1, Liu H1, Wang J1, Liu P1, Tan X1, Ren B1, Liu Z1, Liu X(PubMed)
(2) Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway by Zhao B1, Ren B1, Guo R1, Zhang W1, Ma S1, Yao Y1, Yuan T1, Liu Z1, Liu X2(PubMed)

*How To Protect Against Retinal Degeneration, US National Library of Medicine Studies Show

Green tea phenolic content may have a sustainable and therapeutic effect in reduced risk and progression of retinal degeneration, some scientists suggested.


Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Retinal degeneration is a macular disease characterized by impaired vision, night blindness, retinal detachment, light sensitivity, tunnel vision, and loss of peripheral vision to total loss of vision.

The evaluation of green tea effect in risk of retinal degeneration was found to be implicated by several mechanisms through numbers of aspects.

In ROS implication of oxidative stress-induced degeneration of the retina occurred in age-related macular degeneration (AMD) and glaucoma, application of green tea polyphenols epigallocatechin gallate (EGCG) exhibited antioxidant effect as free radical scavenger in ameliorated chain reaction of ROS in causing loss of neuron with direct effects of retinal function and reduced cytotoxicy of free radicals in induction of retinal cellular apoptosis.

Administration of green tea phynolic compound exerted 10 times more effective in treatment of retinal degeneration, in compared to potent medicine trolox (vitamin E analogue) in attenuating lipid peroxidation caused by the nitric oxide donor, sodium nitroprusside (SNP), according to the study.


Particularly, green tea epigallocatechin gallate (EGCG) inhibited a significant decrease of photoreceptor-specific markers (RET-P1, rhodopsin kinase), an indication of photoreceptor cells in the transition to degenerate prematurely, eventually resulting in blindness.

Also, the application reduced an increase in the cell death marker caspase-3 caused by oxidative stress induced by injection of sodium nitroprusside (SNP)

Caspase 3 is an important marker of apoptosis and one of side effect of sodium nitroprusside (SNP) is cyanide toxicity, that can induce over expression ROS in facilitated free radical chain reaction.


According to the observation by Western blotting techniques, SNP was completely inhibited by EGCG injection in ameliorated the detrimental effects to the retina.

Dr. Zhang B, the co-author said, "Since oxidative stress has been implicated in retinal diseases like AMD and glaucoma this study provides "proof of principle" for the idea that daily intake of EGCG may help individuals suffering from retinal diseases where oxidative stress is implicated".


More interestingly, BALB/cJ mice treated with either EGCG or saline via intraperitoneal (IP) injection, and then placed under constant cool white light-emitting diode (LED) light (10,000 lux) for 5 h, showed a strong protective effect on the retina against light damage (LD) in compared to the control group.


In the examine the retinal structure and function after LD, according to the optical coherence tomography (OCT) and electroretinography (ERG), application of green tea EGCG improved significantly higher ERG amplitudes for all three wave types through inducing morphologic protection of photoreceptors in compared to control.

Moreover, the green tea extract bio-compound also decreased oxidative stress through increase the mRNA level of the antioxidant expression of Sod2, a manganese-dependent superoxide dismutase (MnSOD) before LD and 24 h after LD.

Dr. Qi S1,, the lead author said, "The IP injection of EGCG attenuated the detrimental effects of bright light on the retinas of BALB/cJ mice by protecting the structure and function of the retina".


Importantly, in study to evaluate green tea EGCG effect in reduced glutamate and induced excitotoxicity in the retina, researchers conducted a study of female Wistar rats (n = 171) randomly assigned into
*. A normal control group (n = 9);
*. Saline control group with intravitreal saline injections (n = 54);
*. NMDA control group with an intravitreal NMDA injection;
*. Intraperitoneal saline injections (n = 54); and
*. NMDA study group (n = 54) receiving an intravitreal NMDA injection plus intraperitoneal EGCG (25 mg/kg) injections.

Observation of the groups at 2 weeks after additional injection of NMDA, showed that group treated with intraperitoneal application of EGCG reduced a significantly less marked NMDA-associated loss of retinal ganglion cell, through
* Inhibition of decreasing retinal ganglion cell layer (GCL), neurons located near the inner surface (the ganglion cell layer) of the retina of the eye in received visual information from photoreceptors.

These results were observed by differentiation of Thy-1 immunoreactivity in several areas of the immature and adult human brain in expression of retinal ganglion cell damage.

Thy-1 is mostly is expressed by the ganglion cells within the retina and used to index ganglion cell death after ischemia and excitotoxicity.

And NMDA excitotoxicity is associated to the death of retinal ganglion cells (RGCs).


Taken together, there is no doubt that Epigallocatechin-3-gallate (EGCG), a major polyphenol of green tea, may be used combination with standard therapy for protection and treatment of retinal degenerative disease


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299Sources

(1) Oxidative-induced retinal degeneration is attenuated by epigallocatechin gallate by Zhang B1, Osborne NN(PubMed)
(2) Neuroprotective effect of epigallocatechin-3-gallate against N-methyl-D-aspartate-induced excitotoxicity in the adult rat retina by Chen F1, Jiang L, Shen C, Wan H, Xu L, Wang N, Jonas JB(PubMed)
(3) Intraperitoneal injection of (-)-Epigallocatechin-3-gallate protects against light-induced photoreceptor degeneration in the mouse retina by Qi S1,2, Wang C1,2, Song D2, Song Y2, Dunaief JL2.(PubMed)--

Garlic, The Best Whole Food That Gobbles Up Cancer Cells, Scientists Say

Kyle J. Norton, Master of Nutrition

Garlic (Allium sativum) may have a potential effect in prevention and treatment of cancers by gobbling up cancer cells before they can proliferate to the invasive tumor, some studies suggested.

Cancers is a class of chronic diseases characterized by uncontrollable cells grown in tissue in the body.

At the later stage,  the cancerous cells can infect other healthy cells and tissue far away from the original site by traveling through blood and lymph.

The diseases are the second cause of death in the US.

According to statistic, between 2011-2015, by the national Cancer Institute, 440 per 100,000 adults are diagnosed with cancers, inducing 163.5 per 100,000 death

Depending on types of cancer, patients may experience certain general and specific symptoms.

DNA alternation caused by an inherited gene mutation in induction abnormal cells proliferation is the major cause of cancers.

The National Cancer Institute suggested that age, excessive alcohol consumption, unhealthy diet and lifestyle, smoking, radiation, viruses, carcinogens, obesity,... and chronic inflammation,  are also considered as some major risk factors that can cause cancers. (As these factors are accumulated through many studies in which all point to a similar association between a potential risk factor and an increased risk of cancer).

Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. 

The pungent herb has been used popularly in traditional and Chinese medicine for treating common cold and flu, blood pressure cholesterol levels,..... and as a natural antibiotic.

Garlic appears to be generally safe although some people may suffer mild allergic reactions.

A recent study lead by author Dr. Oommen S indicated that allicin, the main ingredient found in garlic induces the formation of apoptotic bodies, nuclear condensation and a typical DNA ladder in cancer cells, causing cell death.

Researchers in the study of ingredient allicin also showed that the phytochemical is capable in inducing an increase of the rate of apoptosis by obstructing the expression the cell cycle division and  pro-inflammation.

On cancer HL60 and U937 cell lines, allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway by involving the activation of the mitochondrial apoptotic pathway through promoted GSH depletion and changes in the intracellular redox status.

In the research of the function of 20 compounds from garlic, researchers at the Kerala Agricultural University, Kerala, suggested that garlic Phytocompounds Possess Anticancer Activity by Specifically Targeting Breast Cancer Biomarkers.

Other compounds found in garlic such as organosulfur, its extract and phyto-compounds also suppressed cancer cells proliferation and induced cell cycle arrest.

Therefore, people who are at higher risk of the diseases may consider adding a portion of garlic whole food into their diet for preventive measure.

However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of garlic anti-cancer possibilities.

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How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells by Oommen S1, Anto RJ, Srinivas G, Karunagaran D.(PubMed)
(2) Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA by Park SY1, Cho SJ, Kwon HC, Lee KR, Rhee DK, Pyo S.(PubMed)
(3) Allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway in HL60 and U937 cells by Miron T1, Wilchek M, Sharp A, Nakagawa Y, Naoi M, Nozawa Y, Akao Y.(PubMed)
(4) Garlic Phytocompounds Possess Anticancer Activity by Specifically Targeting Breast Cancer Biomarkers - an in Silico Study by Roy N1, Davis S, Narayanankutty A, Nazeem P, Babu T, Abida P, Valsala P, Raghavamenon AC.(PubMed)
(5) Garlic-derived organosulfur compound exerts antitumor efficacy via activation of MAPK pathway and modulation of cytokines in SGC-7901 tumor-bearing mice by Jiang X1, Zhu X1, Huang W1, Xu H1, Zhao Z2, Li S1, Li S3, Cai J3, Cao J3.(PubMed)
(6) Garlic extract in bladder cancer prevention: Evidence from T24 bladder cancer cell xenograft model, tissue microarray, and gene network analysis by Kim WT1, Seo SP2, Byun YJ1, Kang HW1, Kim YJ1, Lee SC1, Jeong P1, Seo Y3, Choe SY3, Kim DJ4, Kim SK5, Moon SK6, Choi YH7, Lee GT8, Kim IY8, Yun SJ1, Kim WJ1.(PubMed)
(7) EGFR gene regulation in colorectal cancer cells by garlic phytocompounds with special emphasis on S-Allyl-L-Cysteine Sulfoxide by Roy N1, Nazeem PA2, Babu TD3, Abida PS2, Narayanankutty A3, Valsalan R2, Valsala PA2, Raghavamenon AC3.(PubMed)

Garlic, the Kitchen Spice That Blocks the Conditions for Developing Cardiovascular Diseases

Kyle J. Norton, Master of Nutrition

Recent study suggested that garlic may be used for prevention and treatment of cardiovascular disease (CVD).

Cardiovascular disease refers to heart diseases, affecting millions of people in the world.

According to statistic, over 17.7 million people died from CVDs in 2015.

The World Heart Foundation, in the investigation of CVD, suggested that CVD risk factors can be classified by
* Non-Modified risk factors such as age, ethnic background,....... and family history. The risk that can not be controlled
* Modified risk factors such as smoking, high blood cholesterol, and pressure, diabetes physical inactivity,.... and overweight. These types of risks can be controlled through a change in life style and diet.

Most common symptoms of CVD include chest pain, neck, jaw, shoulder, arms, or back pain, shortness of breath, sweating, ..... and light-headedness.

If you experience some of the above symptoms, you may have CVD. Please check with your doctor to rule the possibility.

There are many causes of heart disease. Anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease.

According to the Centers for Disease Control and Prevention, heart disease can cause many potentially fatal complications if left untreated. In US 1 in 4 deaths is due to heart disease.

The most common complications of heart diseases are heart failure, the condition occurs when the heart cannot adequately pump blood throughout the body and heart attack, it occurs when the coronary arteries narrow caused by building up of plaques that block the blood supply to the heart.

Some researchers also suggested that CVD can also cause stroke due to blood clots formed in the blood vessels in the brain that obstruct blood flow.

Garlic (Allium sativum) is a species in the onion genus, belongings to family Amaryllidaceae, native to central Asia.

The whole food has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotic, etc.

According to the Nihon University, organosulfur compounds found in garlic stimulate the functions of our body in attenuated risk of cardiovascular diseases.

Dr. Kulczyński B, the lead author insisted that the effectiveness of garlic for prevention and treatment of heart diseases, probably is the result of the whole herb in expression of antioxidant, chemopreventive, anti-inflammatory and immunomodulatory properties.

Other study suggested the role of garlic in alleviating the risks of the metabolic syndrome and cardiovascular complications is due to its modulatory effects on hyperglycaemia, dyslipidemia and oxidative stress.

Garlic also has the potential to treat mild hypertension, decrease hypercholesterolemia, and prevent atherosclerosis, some major risk factors of CVD, according to the joint study lead by the Jordan University of Science and Technologe,

Dr. Alali FQ, the lead author of the study also said, " Garlic (Allium sativum L.), a top-selling herbal dietary supplement, is renowned for its wide range beneficial effects, particularly in the treatment and prevention of CVD".

In fact, data published after year 2000 convincingly pointed out that garlic reduces cardiovascular risk substantially, through inhibition of abnormal plasma lipids, oxidized low density lipoproteins (LDL), abnormal platelet aggregation and a high blood pressure.

These results of stimulating antioxidant, chemopreventive, anti-inflammatory and immunomodulatory properties and inhibiting hypertension, abnormal plasma lipids, oxidized low-density lipoproteins (LDL), abnormal platelet aggregation suggested that garlic may have a strong potential in normalized arteries and blood vessel function against the onset of cardiovascular disease.

Adding garlic into one diet can be helpful if accompanied with the intake of more vegetables, fruits and change of lifestyle in patients with CVD.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Higher blood pressure as a risk factor for diseases other than stroke and ischemic heart disease by Kokubo Y1, Iwashima Y2.(PubMed)
(2) Effect of Garlic and Lemon Juice Mixture on Lipid Profile and Some Cardiovascular Risk Factors in People 30-60 Years Old with Moderate Hyperlipidaemia: A Randomized Clinical Trial by Aslani N1, Entezari MH1, Askari G2, Maghsoudi Z2, Maracy MR3.(PubMed)
(3) Prevention of Cardiovascular Diseases by Garlic-Derived Sulfur Compounds by Seki T1, Hosono T.(PubMed)
(4) Garlic (Allium sativum L.) and cardiovascular diseases by Ginter E1, Simko V.(PubMed)
(5) The importance of selected spices in cardiovascular diseases by Kulczyński B1, Gramza-Michałowska A1. (PubMed)
(6) Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin-nicotinamide diabetic rats by Madkor HR1, Mansour SW, Ramadan G.(PubMed)
(7) Garlic for Cardiovascular Disease: Prevention or Treatment? by Alali FQ1, El-Elimat T2, Khalid L2, Hudaib R2, Al-Shehabi TS3, Eid AH4.(PubMed)

*Coffee Lovers: Beware of Adverse Effect of Bladder Cancer's Risk

By Kyle J. Norton, Master of Nutrition


Coffee consumption may have a strong association to potential risk of bladder cancer development,
some scientists suggested.

Bladder cancer is medical condition of cell growth irregularly and disorderly in the bladder. The cancer may spread to distant tissues and organs in the later stage.

Depending to the originated and infected tissue,  bladder cancer  can be classified into 3 types(4), including
* Transitional cell carcinoma
In early stage of bladder cancer, normal cells become cancerous in the innermost tissue layer of the bladder beginning in cells in the lining of the bladder.

* Squamous cell carcinoma
Cancer begins in squamous cells in the found in the tissues of the surface of the bladder, due to long-term infection or irritation

* Adenocarcinoma
Cancer begins originates in glandular tissue of the bladder, including the surface layer of skin, glands and a variety of other tissue, due to long-term irritation and inflammation.

Deepening to the stage, patients with bladder can may experience some of the below symptoms, bladder spasms, blood in urine, frequent urination, pain or burning sensation during urination, pain in lower back and/or abdomen, reduced bladder capacity, difficult in urination,.... and common symptoms of  loss of appetite and weight.

If you experience some of the symptoms above, please check with your doctor right the way.

Although the single cause of bladder cancer is still debatable, some scientists suggested that smoking,
chemicals exposure, diet high in fried meats and fat,   aging are substantial risk factors in development of  bladder cancer.

According to statistic
* Bladder cancer is the ninth most common cancer in the world.

* Every years over 430,000 new cases are diagnosed in 2012. And

* Men are 4 times more likely to develop bladder cancer in compared to women..

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

According to the Shandong University, in the review literature published online satisfied the criteria and guideline to investigate risk of bladder cancer among coffee consumption adults. Selected studies, numbers of cups/day and relative risk RR as follow
For 23 case-control studies
1. for 1 cup/day, RR=1.07
2 for 2 cups/day, RR=1.15
3 for 3 cups/day, RR=1.22
4. for 4 cups/day RR= 1.29
and
For 5 cohort studies
1. for 1 cup/day, RR=1.09
2. for 2 cups/day, RR=1.13
3. for 3 cups/day, RR= 1.09
4 for 4 cups/day, RR=1.01

The findings in both case-control and cohost studies showed a positive association of coffee intake and risk of bladder cancer.

In non smokers, according to the pooled data set comprises 564 cases and 2929 hospital or population controls enrolled in ten studies conducted in Denmark, Germany, Greece, France, Italy and Spain. risk of bladder caner did not increase monotonically with dose but for heavy coffee drinkers of over 10 cups per days, the risk bladder cancer increases substantially.

Dr. Sala M, the lead author said, "Nonsmokers who are heavy coffee drinkers may have a small excess risk of bladder cancer".

Other, in the analysed a case-control study in two different areas of northern Italy (555 cases and 855 controls), coffee intake and risk of bladder cancer showed that
in compared to non drinkers(RR: relative risk ratio)
1. RR 1.2 for one cup of coffee per day,
2. RR 1.4 for two,
3. RR 1.5 for three and
4 RR 1.4 for four or more
5. RR 1.5 (0.9-2.4) for decaffeinated coffee.
But in never smoked participants, the risk of bladder cancer increased significantly
1 .RR 1.9 for one or two cups per day,
2. RR 1.8 for three and
3 RR 1.5 for four or more

Taking together, there is no doubt that coffee and coffee caffeine consumption have a mild risk in exhibited incidence of bladder cancer regardless to numbers of cups intake daily and regularly.

However, Due to the small size of the studies, some researchers suggested that  a sample size of clinical trial with multi centers involved are necessary to rule out or re confirm the side effect of coffee intake possibility.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) A dose-response meta-analysis of coffee consumption and bladder cancer by Zhou Y1, Tian C, Jia C.(PubMed)
(2) Coffee consumption and bladder cancer in nonsmokers: a pooled analysis of case-control studies in European countries by Sala M1, Cordier S, Chang-Claude J, Donato F, Escolar-Pujolar A, Fernandez F, González CA, Greiser E, Jöckel KH, Lynge E, Mannetje A, Pohlabeln H, Porru S, Serra C, Tzonou A, Vineis P, Wahrendorf J, Boffetta P, Kogevina M.(PubMed)
(3) Coffee consumption and bladder cancer risk by D'Avanzo B1, La Vecchia C, Franceschi S, Negri E, Talamini R, Buttino I.(PubMed)
(4) Bladder Cancer by Kyle J. Norton

Beware of Coffee Side Effect of Speeding Up of Bone Density Loss in Menopause

By Kyle J. Norton


Increased lifelong intake of coffee caffeine >300 mg/day or 2 cups per day may have a potential effect in reduced bone mineral density in menopause women, a Southern America University suggested.

Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.

 It is a widespread degenerative disease of skeletal joints and often associated with senescence invertebrates due to excessive or abnormal mechanical loading of weight-bearing joints, arising from heavy long-term use or specific injuries(4).

Generally, patients may experience symptoms lower back pain, loss of height over time, a stooped posture,.... and neck pain.

Menopause women with osteoporosis are more likely also experience certain psychosomatic, gastrointestinal and swelling and vasomotor symptoms, especially depressive symptom if compared to women in generally good health.

The single cause of osteoporosis is still detectable. Some researchers suggested that the process of wear and repair, poor nutrients,... and cartilage degeneration are possible causes of the disease.

And, according to the Korea Cancer Center Hospital, Seoul, the risk of osteoporosis increased in patients who have diagnosed at the young age puberty, male, decreased lean mass.

Other risk factors may include the use of growth hormone replacement, age,,... and family history of osteoporosis.

According to the statistic by the National Osteoporosis Foundation reported that by 2010, about 12 million people over the age of 50 are expected to have osteoporosis and another 40 million to have low bone mass. By 2020, it is expected to increase to 14 million cases of osteoporosis and over 47 million cases of low bone mass [147](5).

This increase in cases could cause the number of hip fractures to double or triple by 2040 [148](5).

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

In a study to investigate whether increased coffee intake expressed a linear effect in risk of increased aging bone density of  980 postmenopausal women aged 50 to 98 years (mean age, 72.7 years) in community-based population of older women, Rancho Bernardo, Calif.participated between 1988 and 1991, researchers showed that women drinking coffee without adding milk have a strong effect in risk of osteoporosis, but for women drinking at least one cup of milk a day, coffee caffeine intake does not impede bone density.

Milk + coffee= No risk of osteoporosis. Caffeine does not have any effect if coffee drinkings are > 1 cup per day. 


Dr. Barrett-Connor E, the lead author said, "Lifetime caffeinated coffee intake equivalent to two cups per day is associated with decreased bone density in older women who do not drink milk on a daily basis".

Long-term caffeinated coffee intake = 2 cups are associated to decrease bone density.

Other, in the measured the bone density of both hips and the total body in 138 healthy, postmenopausal women aged 55-70 y who never used hormone replacement therapy, returned reports including current and long-time caffeinated beverage, suggested that with the same anthropometric and nutrient intakes, caffeine intake was not associated with osteoporosis regardless of numbers of cups drinking per day.

Caffeine intake was not associated with osteoporosis regardless of numbers of cups drinking per day.

Interestingly, based on brewed beverages chemical analysis, most computer models have overestimated the caffeine intake of prospects by nearly two-thirds.

Based on the finding, Dr. Lloyd T. the lead author said, " the habitual dietary caffeine intake of this cohort of 138 postmenopausal women ranged from 0-1400 mg/d and was not associated with total body or hip bone mineral density measurements".

Caffeine intake of  0-1400 mg/d was not associated with total body or hip bone mineral density.

Furthermore, according to the Creighton University, School of Medicine study of cross-sectional measurements of BMD in 489 elderly women (aged 65-77 y) and from longitudinal measurements made in 96 of these women who were treated with coffee in compared to a placebo for 3 y. showed a nonlinear result of osteoporosis risk increased in women drinking over < or =300 mg/d in compared to low and moderated groups.

 Risk of osteoporosis increased in women drinking over or =300 mg/d in compared to low and moderated groups.

The study also specified that all 3 groups showed some forms of bone density loss, and higher bone density loss is correlated to cups of coffee drinking per day.

Particularly, Dr, Rapuri PB, said, "Intakes of caffeine in amounts >300 mg/d ( approximately 514 g, or 18 oz, brewed coffee) accelerate bone loss at the spine in elderly postmenopausal women".

Conclusion
Menopause women may have an increased risk of mineral bone density in the induction of osteoporosis for caffeine intake  >300 mg/day (approximately 514 g, or 18 oz, brewed coffee). 


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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee-associated osteoporosis offset by daily milk consumption. The Rancho Bernardo Study by Barrett-Connor E1, Chang JC, Edelstein SL.(PubMed)
(2) Dietary caffeine intake and bone status of postmenopausal women by Lloyd T1, Rollings N, Eggli DF, Kieselhorst K, Chinchilli VM.(PubMed)
(3) Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes by Rapuri PB1, Gallagher JC, Kinyamu HK, Ryschon KL.(PubMed)
(4)The Research and studies of Musculoskeletal disorders (MSDs): Osteoporosis by Kyle J. Norton
(5) OSTEOPOROSIS FACTS ANDSTATISTICS by the International Osteoporosis Foundation

* Infectious Diseases: Alfalfa, The Anti Microbial Herbal Remedy

Kyle J. Norton, Master of Nutrition


Alfalfa may be a potential anti microbial agent used for treatment of infection or infectious related diseases.

Microorganism, first observed by Anton van Leeuwenhoek in 1675 is a class of microscopic organism, including a bacterium, virus, or fungus.

Believe or not, single-celled like bacteria, algae and protozoa, or multicellular, such as algae and fungi can survive under all types of extreme environment.

 And less than 1% of bacteria, can invade and cause infection and diseases.

Although the discovery of human antibiotics are medicines that kill or slow the growth of bacteria, however, over uses of the antibiotics have been found to induce microbial resistance to certain drugs.

Dr. Jose M. Munita, the lead author in the study of " Mechanisms of Antibiotic Resistance" said, "Emergence of resistance among the most important bacterial pathogens is recognized as a major public health threat affecting humans worldwide" and " The bacterial response to the antibiotic “attack” is the prime example of bacterial adaptation and the pinnacle of evolution. “Survival of the fittest” is a consequence of an immense genetic plasticity of bacterial pathogens that trigger specific responses that result in mutational adaptations, acquisition of genetic material or alteration of gene expression producing resistance to virtually all antibiotics currently available in clinical practice"(4).

Some researchers in the concerns of antibiotics serious side effects in treatment of diseases suggested that clinicians should eliminate the use of drugs associated with chronic or fatal because multiple therapeutic alternatives exist for virtually every potential infection(5).

Truly, herbal teas has been used popularly as natural alternatives for the treatment of infectious diseases. Dr. Mayram Hacioglu, has found 31 herbal teas that may be  alone and in combination with antibiotics or antifungals against some standard and clinical isolates antimicrobial activities(6).

Alfalfa is a flowering plant in the genus Medicago, belongings to the family Fabaceae, cultivated all over the world as hay for cattle feeding, and used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney and urinary tract infection, etc.

North American aboriginal have used Alfalfa seed as food, such as making bread and mush.

According to the Via Orabona 4, Università, chemical compound saponins found in alfalfa family exhibited anti microbial activities in a selection of medically important yeasts, Gram-positive and negative bacteria.

Dr. Avato P, the lead author said, "(The anti micrbial) Activity (of alfalfa)was especially high against Gram-positive bacteria (Bacillus cereus, B. subtilis, Staphylococcus aureus and Enterococcus faecalis) with M. arabica being the species showing a broader spectrum of action. Discrete antifungal activity was also observed, mainly against Saccharomyces cerevisiae".

Furthermore, in the study of 40 steers fed either a sainfoin (hay or silage) or alfalfa (hay or silage) diet over a 9-week period, in vitro, alfalfa fed group showed a decline in fecal E. coli numbers marginally.

The study also suggested the result of decline of anti E. coli number is due to the presence of phytochemical phenolics in alfalfa.

In fact, The Karunya University in the investigation of Antimicrobial of Alfalfa(Medicago sativa) in various bacterial strain showed a positive effects of alfalfa seed extract in inhibition of
five bacterial strains namely Bacillus licheniformis, Pseudomonas aeruginosa, Lactococcus lactis, Klebsiella pneumonia. The efficacy also depend on concentration of extract with the maximum inhibition was seen in 300µg/ml concentration of extract.

There is no doubt that intake of alfalfa regularly may be beneficiary in reduced risk and treatment of microbial infection and diseases. But further human trials are necessary.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Antimicrobial activity of saponins from Medicago sp.: structure-activity relationship by Avato P1, Bucci R, Tava A, Vitali C, Rosato A, Bialy Z, Jurzysta M.(PubMed)
(2) Potential to reduce Escherichia coli shedding in cattle feces by using sainfoin (Onobrychis viciifolia) forage, tested in vitro and in vivo by Berard NC1, Holley RA, McAllister TA, Ominski KH, Wittenberg KM, Bouchard KS, Bouchard JJ, Krause DO.(PubMed)
(3) Antimicrobial screening of Alfalfa(Medicago sativa) in various bacterial strains by G.SHEELA JOY1 , and Dr.PHILOMENA GEORGE2 *. *Professor, 1B.Tech.student Department Biotechnology, Karunya University, Coimbatore, Tamil Nadu, India 641114(IJPDA)
(4) Mechanisms of Antibiotic Resistance by Jose M. Munita1,2,4 and Cesar A. Arias(PubMed)
(5) Antibiotic side effects by Cunha BA(PubMed)
(6) Antimicrobial activities of widely consumed herbal teas, alone or in combination with antibiotics: an in vitro study by Mayram Hacioglu, Sibel Dosler, Ayse Seher Birteksoz Tan, and Gulten Otuk(PMC)