*Coffee Lovers: Beware of Adverse Effect of Bladder Cancer's Risk

By Kyle J. Norton, Master of Nutrition


Coffee consumption may have a strong association to potential risk of bladder cancer development,
some scientists suggested.

Bladder cancer is medical condition of cell growth irregularly and disorderly in the bladder. The cancer may spread to distant tissues and organs in the later stage.

Depending to the originated and infected tissue,  bladder cancer  can be classified into 3 types(4), including
* Transitional cell carcinoma
In early stage of bladder cancer, normal cells become cancerous in the innermost tissue layer of the bladder beginning in cells in the lining of the bladder.

* Squamous cell carcinoma
Cancer begins in squamous cells in the found in the tissues of the surface of the bladder, due to long-term infection or irritation

* Adenocarcinoma
Cancer begins originates in glandular tissue of the bladder, including the surface layer of skin, glands and a variety of other tissue, due to long-term irritation and inflammation.

Deepening to the stage, patients with bladder can may experience some of the below symptoms, bladder spasms, blood in urine, frequent urination, pain or burning sensation during urination, pain in lower back and/or abdomen, reduced bladder capacity, difficult in urination,.... and common symptoms of  loss of appetite and weight.

If you experience some of the symptoms above, please check with your doctor right the way.

Although the single cause of bladder cancer is still debatable, some scientists suggested that smoking,
chemicals exposure, diet high in fried meats and fat,   aging are substantial risk factors in development of  bladder cancer.

According to statistic
* Bladder cancer is the ninth most common cancer in the world.

* Every years over 430,000 new cases are diagnosed in 2012. And

* Men are 4 times more likely to develop bladder cancer in compared to women..

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

According to the Shandong University, in the review literature published online satisfied the criteria and guideline to investigate risk of bladder cancer among coffee consumption adults. Selected studies, numbers of cups/day and relative risk RR as follow
For 23 case-control studies
1. for 1 cup/day, RR=1.07
2 for 2 cups/day, RR=1.15
3 for 3 cups/day, RR=1.22
4. for 4 cups/day RR= 1.29
and
For 5 cohort studies
1. for 1 cup/day, RR=1.09
2. for 2 cups/day, RR=1.13
3. for 3 cups/day, RR= 1.09
4 for 4 cups/day, RR=1.01

The findings in both case-control and cohost studies showed a positive association of coffee intake and risk of bladder cancer.

In non smokers, according to the pooled data set comprises 564 cases and 2929 hospital or population controls enrolled in ten studies conducted in Denmark, Germany, Greece, France, Italy and Spain. risk of bladder caner did not increase monotonically with dose but for heavy coffee drinkers of over 10 cups per days, the risk bladder cancer increases substantially.

Dr. Sala M, the lead author said, "Nonsmokers who are heavy coffee drinkers may have a small excess risk of bladder cancer".

Other, in the analysed a case-control study in two different areas of northern Italy (555 cases and 855 controls), coffee intake and risk of bladder cancer showed that
in compared to non drinkers(RR: relative risk ratio)
1. RR 1.2 for one cup of coffee per day,
2. RR 1.4 for two,
3. RR 1.5 for three and
4 RR 1.4 for four or more
5. RR 1.5 (0.9-2.4) for decaffeinated coffee.
But in never smoked participants, the risk of bladder cancer increased significantly
1 .RR 1.9 for one or two cups per day,
2. RR 1.8 for three and
3 RR 1.5 for four or more

Taking together, there is no doubt that coffee and coffee caffeine consumption have a mild risk in exhibited incidence of bladder cancer regardless to numbers of cups intake daily and regularly.

However, Due to the small size of the studies, some researchers suggested that  a sample size of clinical trial with multi centers involved are necessary to rule out or re confirm the side effect of coffee intake possibility.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) A dose-response meta-analysis of coffee consumption and bladder cancer by Zhou Y1, Tian C, Jia C.(PubMed)
(2) Coffee consumption and bladder cancer in nonsmokers: a pooled analysis of case-control studies in European countries by Sala M1, Cordier S, Chang-Claude J, Donato F, Escolar-Pujolar A, Fernandez F, González CA, Greiser E, Jöckel KH, Lynge E, Mannetje A, Pohlabeln H, Porru S, Serra C, Tzonou A, Vineis P, Wahrendorf J, Boffetta P, Kogevina M.(PubMed)
(3) Coffee consumption and bladder cancer risk by D'Avanzo B1, La Vecchia C, Franceschi S, Negri E, Talamini R, Buttino I.(PubMed)
(4) Bladder Cancer by Kyle J. Norton

Beware of Coffee Side Effect of Speeding Up of Bone Density Loss in Menopause

By Kyle J. Norton


Increased lifelong intake of coffee caffeine >300 mg/day or 2 cups per day may have a potential effect in reduced bone mineral density in menopause women, a Southern America University suggested.

Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.

 It is a widespread degenerative disease of skeletal joints and often associated with senescence invertebrates due to excessive or abnormal mechanical loading of weight-bearing joints, arising from heavy long-term use or specific injuries(4).

Generally, patients may experience symptoms lower back pain, loss of height over time, a stooped posture,.... and neck pain.

Menopause women with osteoporosis are more likely also experience certain psychosomatic, gastrointestinal and swelling and vasomotor symptoms, especially depressive symptom if compared to women in generally good health.

The single cause of osteoporosis is still detectable. Some researchers suggested that the process of wear and repair, poor nutrients,... and cartilage degeneration are possible causes of the disease.

And, according to the Korea Cancer Center Hospital, Seoul, the risk of osteoporosis increased in patients who have diagnosed at the young age puberty, male, decreased lean mass.

Other risk factors may include the use of growth hormone replacement, age,,... and family history of osteoporosis.

According to the statistic by the National Osteoporosis Foundation reported that by 2010, about 12 million people over the age of 50 are expected to have osteoporosis and another 40 million to have low bone mass. By 2020, it is expected to increase to 14 million cases of osteoporosis and over 47 million cases of low bone mass [147](5).

This increase in cases could cause the number of hip fractures to double or triple by 2040 [148](5).

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

In a study to investigate whether increased coffee intake expressed a linear effect in risk of increased aging bone density of  980 postmenopausal women aged 50 to 98 years (mean age, 72.7 years) in community-based population of older women, Rancho Bernardo, Calif.participated between 1988 and 1991, researchers showed that women drinking coffee without adding milk have a strong effect in risk of osteoporosis, but for women drinking at least one cup of milk a day, coffee caffeine intake does not impede bone density.

Milk + coffee= No risk of osteoporosis. Caffeine does not have any effect if coffee drinkings are > 1 cup per day. 


Dr. Barrett-Connor E, the lead author said, "Lifetime caffeinated coffee intake equivalent to two cups per day is associated with decreased bone density in older women who do not drink milk on a daily basis".

Long-term caffeinated coffee intake = 2 cups are associated to decrease bone density.

Other, in the measured the bone density of both hips and the total body in 138 healthy, postmenopausal women aged 55-70 y who never used hormone replacement therapy, returned reports including current and long-time caffeinated beverage, suggested that with the same anthropometric and nutrient intakes, caffeine intake was not associated with osteoporosis regardless of numbers of cups drinking per day.

Caffeine intake was not associated with osteoporosis regardless of numbers of cups drinking per day.

Interestingly, based on brewed beverages chemical analysis, most computer models have overestimated the caffeine intake of prospects by nearly two-thirds.

Based on the finding, Dr. Lloyd T. the lead author said, " the habitual dietary caffeine intake of this cohort of 138 postmenopausal women ranged from 0-1400 mg/d and was not associated with total body or hip bone mineral density measurements".

Caffeine intake of  0-1400 mg/d was not associated with total body or hip bone mineral density.

Furthermore, according to the Creighton University, School of Medicine study of cross-sectional measurements of BMD in 489 elderly women (aged 65-77 y) and from longitudinal measurements made in 96 of these women who were treated with coffee in compared to a placebo for 3 y. showed a nonlinear result of osteoporosis risk increased in women drinking over < or =300 mg/d in compared to low and moderated groups.

 Risk of osteoporosis increased in women drinking over or =300 mg/d in compared to low and moderated groups.

The study also specified that all 3 groups showed some forms of bone density loss, and higher bone density loss is correlated to cups of coffee drinking per day.

Particularly, Dr, Rapuri PB, said, "Intakes of caffeine in amounts >300 mg/d ( approximately 514 g, or 18 oz, brewed coffee) accelerate bone loss at the spine in elderly postmenopausal women".

Conclusion
Menopause women may have an increased risk of mineral bone density in the induction of osteoporosis for caffeine intake  >300 mg/day (approximately 514 g, or 18 oz, brewed coffee). 


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee-associated osteoporosis offset by daily milk consumption. The Rancho Bernardo Study by Barrett-Connor E1, Chang JC, Edelstein SL.(PubMed)
(2) Dietary caffeine intake and bone status of postmenopausal women by Lloyd T1, Rollings N, Eggli DF, Kieselhorst K, Chinchilli VM.(PubMed)
(3) Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes by Rapuri PB1, Gallagher JC, Kinyamu HK, Ryschon KL.(PubMed)
(4)The Research and studies of Musculoskeletal disorders (MSDs): Osteoporosis by Kyle J. Norton
(5) OSTEOPOROSIS FACTS ANDSTATISTICS by the International Osteoporosis Foundation

* Infectious Diseases: Alfalfa, The Anti Microbial Herbal Remedy

Kyle J. Norton, Master of Nutrition


Alfalfa may be a potential anti microbial agent used for treatment of infection or infectious related diseases.

Microorganism, first observed by Anton van Leeuwenhoek in 1675 is a class of microscopic organism, including a bacterium, virus, or fungus.

Believe or not, single-celled like bacteria, algae and protozoa, or multicellular, such as algae and fungi can survive under all types of extreme environment.

 And less than 1% of bacteria, can invade and cause infection and diseases.

Although the discovery of human antibiotics are medicines that kill or slow the growth of bacteria, however, over uses of the antibiotics have been found to induce microbial resistance to certain drugs.

Dr. Jose M. Munita, the lead author in the study of " Mechanisms of Antibiotic Resistance" said, "Emergence of resistance among the most important bacterial pathogens is recognized as a major public health threat affecting humans worldwide" and " The bacterial response to the antibiotic “attack” is the prime example of bacterial adaptation and the pinnacle of evolution. “Survival of the fittest” is a consequence of an immense genetic plasticity of bacterial pathogens that trigger specific responses that result in mutational adaptations, acquisition of genetic material or alteration of gene expression producing resistance to virtually all antibiotics currently available in clinical practice"(4).

Some researchers in the concerns of antibiotics serious side effects in treatment of diseases suggested that clinicians should eliminate the use of drugs associated with chronic or fatal because multiple therapeutic alternatives exist for virtually every potential infection(5).

Truly, herbal teas has been used popularly as natural alternatives for the treatment of infectious diseases. Dr. Mayram Hacioglu, has found 31 herbal teas that may be  alone and in combination with antibiotics or antifungals against some standard and clinical isolates antimicrobial activities(6).

Alfalfa is a flowering plant in the genus Medicago, belongings to the family Fabaceae, cultivated all over the world as hay for cattle feeding, and used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney and urinary tract infection, etc.

North American aboriginal have used Alfalfa seed as food, such as making bread and mush.

According to the Via Orabona 4, Università, chemical compound saponins found in alfalfa family exhibited anti microbial activities in a selection of medically important yeasts, Gram-positive and negative bacteria.

Dr. Avato P, the lead author said, "(The anti micrbial) Activity (of alfalfa)was especially high against Gram-positive bacteria (Bacillus cereus, B. subtilis, Staphylococcus aureus and Enterococcus faecalis) with M. arabica being the species showing a broader spectrum of action. Discrete antifungal activity was also observed, mainly against Saccharomyces cerevisiae".

Furthermore, in the study of 40 steers fed either a sainfoin (hay or silage) or alfalfa (hay or silage) diet over a 9-week period, in vitro, alfalfa fed group showed a decline in fecal E. coli numbers marginally.

The study also suggested the result of decline of anti E. coli number is due to the presence of phytochemical phenolics in alfalfa.

In fact, The Karunya University in the investigation of Antimicrobial of Alfalfa(Medicago sativa) in various bacterial strain showed a positive effects of alfalfa seed extract in inhibition of
five bacterial strains namely Bacillus licheniformis, Pseudomonas aeruginosa, Lactococcus lactis, Klebsiella pneumonia. The efficacy also depend on concentration of extract with the maximum inhibition was seen in 300µg/ml concentration of extract.

There is no doubt that intake of alfalfa regularly may be beneficiary in reduced risk and treatment of microbial infection and diseases. But further human trials are necessary.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Antimicrobial activity of saponins from Medicago sp.: structure-activity relationship by Avato P1, Bucci R, Tava A, Vitali C, Rosato A, Bialy Z, Jurzysta M.(PubMed)
(2) Potential to reduce Escherichia coli shedding in cattle feces by using sainfoin (Onobrychis viciifolia) forage, tested in vitro and in vivo by Berard NC1, Holley RA, McAllister TA, Ominski KH, Wittenberg KM, Bouchard KS, Bouchard JJ, Krause DO.(PubMed)
(3) Antimicrobial screening of Alfalfa(Medicago sativa) in various bacterial strains by G.SHEELA JOY1 , and Dr.PHILOMENA GEORGE2 *. *Professor, 1B.Tech.student Department Biotechnology, Karunya University, Coimbatore, Tamil Nadu, India 641114(IJPDA)
(4) Mechanisms of Antibiotic Resistance by Jose M. Munita1,2,4 and Cesar A. Arias(PubMed)
(5) Antibiotic side effects by Cunha BA(PubMed)
(6) Antimicrobial activities of widely consumed herbal teas, alone or in combination with antibiotics: an in vitro study by Mayram Hacioglu, Sibel Dosler, Ayse Seher Birteksoz Tan, and Gulten Otuk(PMC)

* The Root Vegetable That Prevents Macular Degeneration (AMD), Biomedical Literature Suggest

Kyle J. Norton

Carrots may have a profound and positive effect in prevention of mascular degeneration, some scientists suggested.


Macular degeneration is a condition characterized by deterioration of the macula, the small central area of the retina of the eye that controls visual acuity.

Symptoms of early signs of AMD include central vision shadows or unusually fuzzy or distorted vision. 

According to statistic, approximately 6 percent of Americans age 40 and older have some forms of macular degeneration.

There are 2 types of macular degeneration, the dry and wet form.

The dry form is one of most common of macula degeneration accounted for over 85 to 90 % of the disease.

Dry macular degeneration also known as non-neovascular is an early stage of the disease caused by aging and thinning of macular tissues, leading to gradual central vision loss. 

In compared to the dry form, wet macular degeneration (neovascular) is a severed and advanced stage of the disease caused by new blood vessels grow beneath the retina and leak blood and fluid causing permanent damage to light-sensitive retinal cells in induction of blind spots in central vision.

Untreated or advanced stage of wet form AMD are also complicated by complete vision loss.

Dr. Ikram MK the lead author at the Singapore National Eye Centre study, said, "Persons with AMD are (regardless of treatment or not) at an increased risk of both cerebral infarction and intracerebral hemorrhage" and  "These data (the study) provide further insight into common pathophysiological processes between AMD and stroke subtypes"(4).

Conventional medicine used for treatment of AMD, such as Lucentis approved by FDA in 2006 can increase risk of heart attack and stroke.

Carrot, a root vegetable with orange color is a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.


In the investigated the effect of major bioactive phytochemicals lutein and zeaxanthin isolated from orange pigment vegetables, including carrot in eye health, researchers at the Guelph Food Research Centre, found that application of indicated compounds exert a significantly protective effect of the yellow spot of the human retina which protect the macula from damage by blue light and improve visual acuity and scavenge harmful reactive oxygen species. 

Long term exposure to the blue light may cause structural, thermal and photochemical damage to the retinal, particularly, in aging population.

Further analysis also suggested that application of lutein and zeaxanthin increased antioxidants and stimulated natural antioxidants produced by the body tissue in inhibited over expression of free radicals and theirs chain of domino's effects caused by sunlight exposure in induction of oxidative stress.

The restoration of balance of the ratio of reactive oxygen species and antioxidants not only prevented oxidative damage to the cells of retina, but also reduced risk of age-related macular degeneration (AMD) and cataracts, according to the research over the past decade in focused on the development of carotenoid-rich foods to boost their intake especially in the elderly population

Dr. Abdel-Aal el-SM, after taking into account of other co and con founders said, "The review also lists major dietary sources of lutein and zeaxanthin and refers to newly developed foods, daily intake, bioavailability and physiological effects in relation to eye health".

These suggestion not only addressed a strong protective effect of bioactive compound carotenoids found abundantly in carrot in improved eye health but also recommended daily and regular intake of a moderate amount of carrot in aging risk of macular degeneration.

Additionally, in the evaluation of the possibility of macular carotenoids, lutein (L), and zeaxanthin (Z) in ameliorated the retardation of age-related changes in the eye and prevention of the eye diseases such as cataract and macular degeneration, researchers at the University of Georgia suggested that intake of carotenoids rich food, such as carrot in the early life may be the best to protect against eye diseases due to aging.

The benefits of early carotenoids consumption in protected against retard age-related changes in the eye and the eye diseases were associated to influence of the development of the visual system through
* Altered input during a critical/sensitive period of visual development and/or

* Influenced maturation and/or

*Protected the retina during a period when it was particularly vulnerable.

Interestingly, in the differentiation of lutein and zeaxanthin accumulated throughout the tissues of the eye, specially in the central retina, researchers once again strongly found that circulated pigments' antioxidants serve a variety of roles in the specialized human vision, including all aspects of visual performance.

Taken together, Carrot with high amount of carotenoids ( lutein (L), and zeaxanthin) may be considered as functional food in prevention of eye diseases, particularly in older adult.

People with higher risk of eye diseases may want to add a portion of carrot into their daily diet for preventive measure. And intake of carrot extracts should be taken as acute liver toxicity has been reported in numbers of supplement.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Dietary sources of lutein and zeaxanthin carotenoids and their role in eye health by Abdel-Aal el-SM1, Akhtar H, Zaheer K, Ali R.(PubMed)
(2) Possible role for dietary lutein and zeaxanthin in visual development by Hammond BR Jr1(PubMed)
(3) Dietary lutein and zeaxanthin: possible effects on visual function by Stringham JM1, Hammond BR Jr.(PubMed)
(4) Age-related macular degeneration and long-term risk of stroke subtypes by Ikram MK1, Mitchell P, Klein R, Sharrett AR, Couper DJ, Wong TY(PubMed)

* The Veggie and Its Bio Active Compounds That Prevent Stroke

Kyle J. Norton

Carrots may have a profound and positive effect in reduced risk of stroke, some scientists suggested.

Stroke is a medical condition caused by reduced blood flow to the brain resulting in cell death due to blocked artery (ischemic stroke) or the leaking or bursting of a blood vessel (hemorrhagic stroke).

There is a general belief that stroke is an accumulation over along period of unhealthy diet with red meat and processed meats in induction of artery-clogging.

Some researchers suggested that increased intake of fruits and vegetables such as carrot accompanied with good fats such as salmon, tuna, and mackerel may have a substantial effect in reduced inflammation in the arteries, improved blood flow and decreased the chance of blood clots.

Sadly, stroke is one of the most common causes of death worldwide.

In US, according to statistic, approximately 800,000 people suffer a stroke in which 600,000 of these are first attacks, and 185,000 are recurrent attacks. Nearly three-quarters of all strokes occur in people over the age of 65.

Carrot, a root vegetable with orange color is a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

In the review of literature published to understand more of the role of carotenoids as antioxidants in lowering stroke risk based on observational studies, researchers at the Isfahan University of Medical Sciences conducted a search with some important keywords, including (Carotenoids [MeSH] OR Carotenes [tiab] OR Carotene [tiab] OR "lycopene [Supplementary Concept]" [MeSH] OR lycopene [tiab] OR beta-Carotene [tiab]) AND (stroke [MeSH] OR stroke [tiab] OR "Cerebrovascular Accident" [tiab] OR "Cerebrovascular Apoplexy" [tiab] OR "Brain Vascular Accident" [tiab] OR "Cerebrovascular Stroke" [tiab]) AND ("oxidative stress" [MeSH] OR "oxidative stress"[tiab]).

The results of the searching of papers published between 2000 and 2017 suggested that

* High dietary intake of six main carotenoids (i.e., lycopene, <- and®-carotene, lutein, zeaxanthin, and astaxanthin) was associated with reduced risk of stroke due to their benefits in reduced over expression of reactive oxygen species.

* Beyond the antioxidant activities in prevented free radical in induction of chain reaction, other properties and mechanisms in ameliorated risk of stroke were not identified in studies sanctified the guideline and criteria.

These results suggested that dietary intake of six major carotenoids may be considered as stroke prevention and stroke mortality reduction.

Further in differentiation the benefits of lycopene an bioactive member in carotenoids, researchers found that intake of food containing high amount of lycopene demonstrates a substantially reduced risk of stroke in compared to non takers.

According to the assessment of pooled analysis of seven prospective studies, with 116,127 participants and 1,989 cases, frequent consumption of lycopene decreased stroke risk by 19.3%, after adjusting for confounding factors.


In gender and geographic analysis, researchers also stated that lycopene exerts a strong impact in prevent onset of stroke, particularly in European and male gender.

Dr. the lead scientist said, " Duration of follow-up had no effect on the final results. There was no evidence of publication bias" and " Lycopene, especially circulating lycopene, is negatively associated with stroke risk".

Additionally, in the examine the hypothese whether low serum levels of lycopene are associated with increased risk of acute coronary events and stroke in middle-aged men previously free of CHD and stroke , researchers launched an investigation of 725 men aged 46-64 years examined in 1991-3 in the Kuopio Ischaemic Heart Disease Risk Factor Study.

By December 1997, out of 725 patients, 41 men were found to have either a fatal or a non-fatal acute coronary event or a stroke.

According to the observation of a Cox' proportional hazard's model and after adjusting to examination years, age, systolic blood pressure and three nutritional factors (serum folate, beta-carotene and plasma vitamin C), researchers found that all 41 men are in the lowest quarter of serum lycopene levels.

These results once again suggested that daily intake of lycopene rich foods to increase the circulating lycopene plays an essential role in prevented risk of atherosclerotic vascular events in middle-aged men previously free of CHD and stroke.

Truly, patients with lower levels of serum lycopene were found to had a 3.3-fold risk of acute coronary events or stroke in compared with the others.

Taken together, carrot with high ammount of bioactive carotenoids, especially lycopene may be considered as a function food in reduced the prevalent risk of stroke.

People who are at the higher quarter of stroke risk may want to add a portion of carrot into their daily diet for preventive measure.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Carotenoids as Potential Antioxidant Agents in Stroke Prevention: A Systematic Review by Bahonar A1, Saadatnia M1, Khorvash F1, Maracy M2, Khosravi A(PubMed)
(2) Dietary and circulating lycopene and stroke risk: a meta-analysis of prospective studies by Li X1, Xu J2.(PubMed)
(3) Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study by Rissanen TH1, Voutilainen S, Nyyssönen K, Lakka TA, Sivenius J, Salonen R, Kaplan GA, Salonen JT.(PubMed)
(4) Healthy eating and stroke(Stroke Foundation)
(5) Stroke Statistics by The Internet Stroke center

* How to Normalize Your Sex Hormones Androgen and Estrogen Naturally, Revealed by Scientists

By Kyle J. Norton

Coffee, a popular and social beverage, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

A recent study suggested that coffee may have a direct effect in influence of sex hormone steroid-binding globulin(SSBG) in stimulated production of estrogen and androgen depending to levels in the host.

Sex hormones are class of hormones, affecting sexual development and reproduction. Steroid-binding globulin(SSBG), is a sex hormone, having a direct effect on androgen and estrogen.

In sex hormones and sexual differentiation, most influential hormone in human sexual desire is testosterone.

Low levels of estrogen in women can also reduce sex drive caused by vaginal dryness that can lead to painful intercourse

Mentally, women with low levels of estrogen also experience unstable mood and sleep patterns that can have a strong impact in sexual desire.

However, sexual motivation is influenced by a set of hormones, including testosterone, estrogen, progesterone, oxytocin, and vasopressin...... Altogether, they control the ability to engage in sexual behaviors.

The actual causes of abnormal levels of sex hormone are debatable. But all researchers agree that ageing plays an important role in production of the sex hormone steroid-binding globulin(SSBG).

Diseases, also the  risk factors associated to abnormal levels of  serum of SHBG concentrations include obesity, insulin resistance, type 2 diabetes hypothyroidism,  Cushing syndrome, nonalcoholic fatty liver disease, hypertension, ....... and androgen steroid use

The normal ranges for serum of SHBG concentrations in adults are: 

* Males: 10 to 57 nanomoles per liter (nmol/L) 

*Females (nonpregnant): 18 to 144 nmol/L

In a 8-week parallel-arm randomized controlled trial with Healthy adults (n = 42) recruited from the Boston community, including regular coffee consumers, nonsmokers, and overweight, randomized to five 6-ounce cups of caffeinated or decaffeinated instant coffee or water per day, at 4 weeks, researchers surprisingly found that
* Decaffeinated coffee drinking was associated with a borderline significantly increased levels of SHBG in women, but not in men.

*. At week 4, decaffeinated coffee decreased total and free testosterone and caffeinated coffee decreased only total testosterone in women.

*. Contrast to women participants, men consumption of caffeinated coffee displayed a significantly increased total testosterone and decreased total and free estradiol hormones.

*. The study also indicated that caffeinated coffee consumption do not exert any effect on SHBG in either men or women.

These results suggested that intake of coffee may have a strong impact in maintained normal levels of SHBG, thus reducing risk of low levels of SHBG induced higher testosterone levels in overweight women, causing androgenization and development of polycystic ovarian syndrome.

And in men, normal levels of testosterone may also have a significant contribution of healthy libido, building muscle mass, and maintaining energy levels.

Some researchers suggested that increased testosterone level for middle-aged (30 to 50 years old) and older males may also improve the physical energy, strength, stamina, mental aggressiveness which were lost in aging population.

Contrast to above differentiation, in type 2 diabetic patients, coffee and coffee caffeine showed an elevated effect as a mediator of sex hormone-binding globulin in both androgen and estrogen particularly in women in compared to the healthy young adult.

Dr. Eric L. Ding and colleagues in the study to evaluate "Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Women and Men" said, " Among women, higher plasma levels of sex hormone–binding globulin were prospectively associated with a lower risk of type 2 diabetes and " the predicted odds ratio of type 2 diabetes per standard-deviation increase in the plasma level of sex hormone–binding globulin was 0.28 (95% CI, 0.13 to 0.58) among women and 0.29 (95% CI, 0.15 to 0.58) among men".

The analysis strongly suggested that coffee regardless to types have a negative correlation with risk of diabetes through increasing levels of SHBG.

Additionally, according to the cross-sectional study of 2377 nondiabetic pre- and postmenopausal women from the E3N cohort study in a multivariate adjusted model, intake of more than 3 cup of coffee daily coffee and caffeine ≥265 mg/day were associated with an increased SHBG level distribution (<46.3 nmol/L), in compared to no risk association of decaffeinated coffee subgroup.

In other words, in low levels of SHBG nondiabetic pre- and postmenopausal in compared to healthy women, injection of caffeinated coffee increased levels of sexual hormones estrogen and testosterone

The above analysis was supported by the examination of the study during a median follow-up of 10 years of 359 postmenopausal women with newly diagnosed type 2 diabetes matched with 359 control subjects by age, race, duration of follow-up, and time of blood draw, coffee and caffeine were associated to increased levels of fee and total testosterone among postmenopausal women.

In Summary, the evidences indicated that coffee and caffeine have a extreme effect in exhibition of sex hormone estrogen and testosterone through increased lower level of SHBG in menopause women and prevented onset of type 2 diabetes without affecting the serum in healthy individuals.

Decaffeinated coffee decreased total and free testosterone through significantly increased levels of SHBG in overweight women who are at risk of diseases associated to over expression of testosterone.

And caffeinated coffee displayed a significantly increased total testosterone and decreased total and free estradiol in men.

Altogether, coffee may be considered as a function food in mediated production of sexual hormone estrogen and testosterone against diseases and syndromes caused by low levels of SSBG.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The effects of caffeinated and decaffeinated coffee on sex hormone-binding globulin and endogenous sex hormone levels: a randomized controlled trial by Wedick NM1, Mantzoros CS, Ding EL, Brennan AM, Rosner B, Rimm EB, Hu FB, van Dam RM.(PubMed)
(2) Cross-sectional association of coffee and caffeine consumption with sex hormone-binding globulin in healthy nondiabetic women by Pihan-Le Bars F1,2, Gusto G3,4,5, Boutron-Ruault MC3,4,5, Fagherazzi G3,4,5, Bonnet F1,2,3.(PubMed)
(3) Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women by Goto A1, Song Y, Chen BH, Manson JE, Buring JE, Liu S.(PubMed)

* Aloe Vera, The Herb and Plant That Inhibits Polycystic Ovarian Syndrome (PCOs)

By Kyle J. Norton

Scientists from some respectable institutes suggested that aloe vera may have a potential and profound effect in reduced symptoms, risk and treatment of polycystic ovarian syndrome(PCOs).

Polycystic Ovarian Syndrome is a condition characterized by endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women[1].

According to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21)[1].

Women with PCOs may experience some of the symptoms of irregular, oligomenorrhea or absent menstrual periods, male pattern hair growth, acne, weight gain, obstructive sleep apnea, closure of the upper airway, causing stop breathing while sleeping, difficult to conceive, anxiety, emotional disturbance, poor quality of life, menstrual cycle disturbances, depression, autonomic dysfunction, problematic eating and general psychosocial dysfunction.

Aloe Vera is species of succulent plant in the genus Aloe, belongings to the Family Xanthorrhoeaceae, native to Sudan.

The herb is most commercial cultivated due to its health benefits.

Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes,...... and elevated of cholesterol, The herb also is one of many popular herb studied in scientific ways with some conflicted results.

According to the study by Desai BN, Maharjan RH, Nampoothiri LP.  70% PCOS women have abnormal serum lipid levels (dyslipidemia) and 50% of these women are obese.

Several classes of pharmacological agents have been used to manage dyslipidemia with serious   adverse effects.

The ten main areas of chemical constituents of Aloe vera include: amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

They all work together in a synergistic way to create healing and health giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.

Application aloe vera in Charles Foster female rats induced PCOs by oral administration of non-steroidal aromatase inhibitor letrozole (0.5 mg/kg body weight, 21 days) exerts  a significant reductions of plasma triglyceride and LDL cholesterol levels, and increase of HDL cholesterol by restoring the ovarian steroid status.

 The Aloe vera gel treatment also caused reversion of abnormal estrous cyclicity, glucose intolerance, and lipid metabolizing enzyme activities.

Other study also indicated that Aloe vera gel formulation exerts a protective effect in against the PCOS phenotype by altering key steroidogenic activity. These results are attributed to phyto-components in the gel.


Dr.Pérez YY and the research team in the study of Effect of a polyphenol-rich extract from Aloe vera gel on experimentally induced insulin resistance in mice, said,  " the polyphenol-rich extract from Aloe vera. decrease significantly both body weight (p < 0.008) and blood glucose levels, calculated using the homeostasis model assessment for insulin resistance (HOMA-IR)".

Also in the confirmation of above result, the study of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models, vera leaf pulp extract suggested hypoglycaemic activity on IDDM and NIDDM rats, the effectiveness being enhanced for type II diabetes in comparison with glibenclamide.

Taken together, aloe vera can be used as secondary and therapeutic treatment in ameliorated all aspects of symptom, progression and treatment of  polycystic ovarian syndrome.

 However, further data collection performed with human consumption during the course of the investigation are necessary to complete the picture of Aloe Vera, protective effect against polycystic ovarian syndrome (PCOs) possibilities.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
[1]. The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The Symptoms(Revised edition with Citations) by Kyle J. Norton
[2] Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat model by Desai BN, Maharjan RH, Nampoothiri LP.(PubMed)
[3] Effect of Aloe barbadensis Mill. formulation on Letrozole induced polycystic ovarian syndrome rat model by Maharjan R, Nagar PS, Nampoothiri L.(PubMed)
[4].  Drug-induced lupus: an update by Vasoo S.(PubMed)