How to Enhance Fat Metabolism in Prevention of Obesity Naturally, MEDLINE Studies Reveal

By Kyle J. Norton


Green tea may have a therapeutic and positive effect in improved fat metabolism, some scientists suggested.

Fat metabolism is a biological process converted lipid intake to energy for the body needs through breaking down fat into glycerol and fatty acids before being absorbed by the intestines.

Abnormal fat metabolism plays an important factors in the development of obesity and diabetes, according to the study of the University of Colorado Denver.

Green tea, a precious drink processes numbers of health benefit, known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

In the evaulation of the mechanisms of actions of green tea bioactive polyphenol (-)-epigallocatechin-3-gallate (EGCG),on bile acid homeostasis and lipid metabolism, researchers conducted a study of male C57BL/6J mice
* Group 1:  fed with a low-fat diet,
Group 2: fed with high-fat western-style diet or
* Group 3: fed with high-fat western-style diet containing 0.32% green tea bioactive polyphenol (-)-epigallocatechin-3-gallate (EGCG),

According to the differentiation at 17 weeks of experiment, mice group fed with EGCG exhibited a strong effect in reduced body weight gain, mesenteric fat mass, serum cholesterol and severity of fatty liver.

Additional analysis indicated that green tea reduced expression of significantly elevated the mRNA levels of cholesterol 7α-hydroxylase initiated by cholesterol through inhibition of bile acid synthesis in cholesterol metabolism, that enhanced attenuation of lipid absorption.


Injection of green tea EGCG also increased the level of HMG-CoA reductase in inhibited cholesterol synthesis, biliary lipid secretion, and elevated blood cholesterol through activation of low-density lipoprotein receptors which play an important role of limiting step in lipid synthesis.


Moreover, green tea EGCG also elevated scavenger receptor class B type 1 (SRB1), an enzyme with functions as a receptor for high-density lipoprotein in meditating the uptake of HDL-derived cholesterol and cholesteryl ester in the liver.

The enzyme also processes a property in modulating and regulating certain pathways and networks involved cellular lipids in biological systems.

Dr. Huang J, the lead scientist in the joint study at the State University of New Jersey, said, "The intestinal bile acid content was significantly decreased by EGCG, while fecal excretion of bile acids, cholesterol and total lipids were increased" and "EGCG decreases bile acid reabsorption, results in lower intestinal bile acid levels, which further decreased the absorption of lipids".

Further differentiation of the green tea effect by examining the lipid levels associated with obesity in C57BL/6J mice fed a normal diet (ND), HFD and HFD with GT for 12 weeks, scientists indicated that group treated with green tea extract and HFD expresses a significant alternation of levels of several lipid metabolites observed by the partial least squares discriminant analysis score plot.

Mice group fed with high fat diet demonstrated decreased levels of lysophospholipids (LPLs) (lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine) which show a negative correlation with triglyceride hydrolysis and increased fat absorption in compared to normal diet group.

These alternations were not found in mice group fed with HFD plus green tea.

Alternation of lysophospholipid was associated to substantial impact on lysophospholipid metabolism, in contribution of the onset or progression of obesity.

The restoration of lysophospholipids (LPLs) by green tea extract caused by long term high fat diet may be an indication of how green tea reduced expression of inflammation, insulin resistance, and fatty liver disease in obesity.


Interestingly, in the observation of injection of green tea extract in the regulation of hepatic fat metabolism in 36 male chickens fed GTPs at a daily dose of 0, 80 or 160 mg/kg of body weight for 4 weeks, researchers at the joint study lead by the Anhui Agricultural University, suggested that oral administration of green tea polyphenols (GTPs) significantly improves lipid metabolism through reduced hepatic lipid content and abdominal fat mass and abdominal fat mass accumulation which are correlated to onset and progression of over weight and obesity.

Additionally, the application also expressed a strong effect in the phosphorylation levels of AMP-activated protein kinase α (AMPKα) which plays an important role in skeletal muscle fatty acid utilization and in regulated growth and reprogrammed metabolism, and Acetyl-CoA carboxylase 1 (ACACA) in modulation of fat cell cycle stages and cytokinesis, thus reducing fat synthesis and production of pro inflammatory cytokines.

More importantly, green tea polyphenol also altered the mRNA levels and enzymatic activities in suppressed expression of enzymes involved PUFA in the liver in stimulated lipid synthesis and fat oxidation.


Taken together, green tea containing high amount of bioactive polyphenols, such as catechins may be considered as a functional food to reduce onset and progression of over weight and obesity.

 However, intake of green tea extract should be taken with care as acute liver toxicity has been reported in some cases.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Green Tea Polyphenol EGCG Alleviates Metabolic Abnormality and Fatty Liver by Decreasing Bile Acid and Lipid Absorption in Mice by Huang J1,2, Feng S1,3, Liu A1, Dai Z1,4, Wang H1, Reuhl K5, Lu W6, Yang CS1,2.(PubMed)
(2) Effect of green tea on hepatic lipid metabolism in mice fed a high-fat diet by Nam M1, Choi MS2, Choi JY2, Kim N3, Kim MS3, Jung S1, Kim J1, Ryu DH4, Hwang GS5.(PubMed)
(3) Green tea polyphenols alter lipid metabolism in the livers of broiler chickens through increased phosphorylation of AMP-activated protein kinase by Huang J1,2, Zhou Y1, Wan B1, Wang Q1, Wan X1,2.(PubMed)
(4) Increase in serum and bile cholesterol and HMG-CoA reductase by lovastatin in rats by Yamauchi S1, Linscheer WG, Beach DH.(PubMed)

How to Alleviate Severity, Duration & Frequency of Chronic Headache Naturally and Effectively, Medline Studies Find

By Kyle J. Norton

Yoga therapy may have an important role in regulated central versus peripheral mechanisms in expression of chronic headache, the study by the All India Institute of Medical Sciences suggested.

Yoga, the ancient technique for harmonized external and internal body well beings, through breath control, meditation, bodily movement and gesture..... has been best known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

According to the study to investigate the role of muscle spasm over activity in chronic tension type headache (CTTH) with 15 patients of CTTH and 7 age matched controls, randomized assigned to either yoga intervention or control, yoga group demonstrated a significant improvement in reduced overactivity of temporalis muscle in CTTH patients at rest in compared with control.


Furthermore, after examined the EMG records, researchers found that yoga group displays a strong improvement of  subjective pain scores. and a substantial decrease in the mean electromyography (EMG) amplitude of temporalis muscle during rest and mental activity in compared to other applications such as non steroidal anti inflammatory drugs, botulinum toxin injections.

EMG amplitude is medical technique used to evaluate details of the timing and magnitude of muscle activation as well as muscles in powering a variety of types of locomotion.

Truly, yoga breathing and relaxation reduced daily stress through calming the central nervous system by connecting the mind and body, restoring the endocrine system in hormone balancing.

The technique of practice also reduced production of stress hormone cortisol and brought back the present moment, while letting them go or dealing them in a profound way.

Further more, yoga postures and deep breathing ameliorated over expression of nerve neurons in transmitted information of sensation, stress, and suffering by strengthening the flow of energy, thus enhancing relaxation in response to pain through unraveling the mind-body samskaras.

Moreover, in a study of 50 patients (aged 18-58 years) in a clinical diagnosis of CCTH, divided in 2 groups,
* Group 1 (n=30) patients were received 8 lessons and practical demonstration of Brahmakumaris spiritual based meditation known as Rajyoga meditation for relaxation therapy, in addition to routine medical treatment (analgesics and muscle relaxants) and

* Group 2 (n=20) patients were received analgesics and muscle relaxants twice a day but no relaxation therapy in the form of meditation by the Dr. Kiran, and colleagues, to support of the effect of yoga therapy in reduced symptoms and pain in tension types of headache,

After 8 weeks follow up period, scientists showed that both therapies show a highly significant reduction in headache variables but yoga group expressed a highly significant relief of severity, duration & frequency of headache by 94%, 91% and 97% in compared to group 2 of 36%, 36% and 49% respectively.

The total headache relief according to headache index was 99% in yoga group in compared to only 51% in control group.

These results indicated that yoga intervention may have an acute effect in ameliorated pain in chronic tension headache.


More promisingly, in the study to provide preliminary data on the feasibility, acceptability, and safety of alignment-based yoga for youths with chronic headaches, researchers at the joint study lead by the Medical College of Wisconsin/Children's Hospital of Wisconsin found that yoga therapy may be considered pediatric headaches treatment, indicated by positive parent and participant ratings of the yoga experience.

In deed, some yoga instructors suggested that the alleviation of stress by yoga exercise in reduced insomnia and swelling and constriction of the blood vessels was a result of yoga in initiated deep sleep and reduced tension of the blood vessels in the face and neck.

Additionally, these results were also associated to yoga exercise effects in enhanced  head muscles relaxation and revitalization and improved hypertension in blood circulation, particularly in people with chronic headache.


The findings suggested that yoga intervention may be used as an integrated form of exercise in provided relief in severity of headache, duration & frequency of chronic headache, particularly in tension types of headache.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Role of temporalis muscle over activity in chronic tension type headache: effect of yoga based management by Bhatia R1, Dureja GP, Tripathi M, Bhattacharjee M, Bijlani RL, Mathur R.(PubMed)
(2) Effect of rajyoga meditation on chronic tension headache by Kiran, Girgla KK, Chalana H, Singh H.(PubMed)
(3) A pilot study of yoga for chronic headaches in youth: promise amidst challenges by Hainsworth KR1, Salamon KS2, Khan KA3, Mascarenhas B4, Davies WH2, Weisman SJ3.(PubMed)
(4) Interpreting muscle function from EMG: lessons learned from direct measurements of muscle force byThomas J. Roberts1,* and Annette M. Gabaldón(PMC)

How to Block the Entry Phase of Prostate Cancer Cells Development Naturally, National Institutes of Health Studies Suggest

Kyle J. Norton


Herbal Catnip may have a potential and substantial effect in reduced risk of pre-malignant cells, caused by slowly change from normal cells to cancer-like properties in initiated prostate cancer, some scientists suggested.

Catnip is also known as catswort, or catmint, a plant of Nepeta, belongings to the family of Lamiaceae, native to Europe and Asia'

The plant has been used in herbal medicine as insect repellent and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritations stimulate sweating, promote menstruation, etc..

Ingredients
Beside the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc..

Prostate cancer is medical condition characterized by irregular cell growth in the issues of prostate.

 At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.

According to statistic, based on 2012-2014 data, approximately 11.6 percent of men are diagnosed with prostate cancer at some points during their lifetime.


On PC3 and DU145 prostate cell lines, in comparison of the effective of methanol extracts, n-hexan, methylene chloride (CH2Cl2), ethyl acetate (EtOAc), n-butanol (n-BuOH), and H2O fractions and the essential oil isolated from the aerial parts of the catnip to examine the cytotoxic and apoptogenic activity, researchers found that application of ethyl acetate extract in compared to other extracts, displays a strong inhibited property in decreased prostate cancer cell viability in PC3 cell line, through cell cycle arrest in the sub-G1 area.

The ethyl acetate extract also caused lost some DNA structure in tested cell lines, in a concentration dependent manner.

Furthermore, through observation of IC 50 values, ethyl acetate (EtOAc) expressed a greater significant activity in estrogen receptor positive PC3 cells which are more sensitive to the cytotoxic effects in comparison with low hormone-receptor presenting DU-145 cells.


Interestingly, ethyl acetate (EtOAc) in inhibited PC3 cancer cell line with lesser value of IC50 and greater effect than other tested compounds,
es
The results of these efficacy were attributed to the activity of PC3 cells which process a property to change its negative androgen receptors profile to positive (PC3AR+)


The study also indicated that more cytotoxic activity of N. cataria found on PC3 cells in comparison with DU145 AR¯ cells might also be associated to different response of cells to sex hormones.

Additionally, according to the Western blotting analysis administration of ethyl acetate extract after 48 hours securely induced cancer apoptosis through activated caspase 3 cleavage  and Poly(ADP-ribose) polymerase (PARP).

Caspase 3 cleavage is an important marker associated to the progression of cancer cell’s entry point into the apoptotic signaling pathway.

Poly(ADP-ribose) polymerase (PARP) plays an essential role in execution of the cells apoptosis and is considered as an early indicator of apoptosis.

Moreover, researchers also found that the Catnip extract also increased level of Bax Protein after 48 hours of exposure in initiated cancer cell apoptosis with release of cytochrome c, an early phase of cell degradation and death.


After taking into account of other con founders, Dr. Emami SA, the lead author said, " the semi polar EtOAc extract of N. cataria induces apoptosis in pc3 cells compare to DU-145 cells and further analytical assays are suggested to identify the active phytochemicals possess cytotoxic activity".


Taking altogether, Catnip and its extract may be considered as a functional food in reduced risk of Prostate cancer through blocking the entry phase of the onset of prostate cancer.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Growth Inhibition and Apoptosis Induction of Essential Oils and Extracts of Nepeta cataria L. on Human Prostatic and Breast Cancer Cell Lines by Emami SA1, Asili J, Hossein Nia S, Yazdian-Robati R, Sahranavard M, Tayarani-Najaran Z. DOI:http://dx.doi.org/10.7314/APJCP.2016.17.S3.125

How To Treat Depression Naturally, US National Library of Medicine Human and Model Studies Show

Kyle J. Norton


Anise may have a potential and substantial effect for treatment of depression, some scientists suggested.

Anise is a flowering plant ofthe species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to to Egypt and the Mediterranean region, used in traditional herbal medicine as fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, ....


Chemical comstituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

Depression is a condition of mood disorder. affecting the patients feel, think, and handle daily activities.

According to statistic of The National Institute of Mental Health, approximately, 16 million adults had at least one major depressive episode in 2012 in the United States, a 6.9 percent of the population.

In the evaluation of the herbal Anise aqueous and ethanol extracts antidepressant-like effect in mice with several different doses of 50, 100 and 200 mg/kg in compared to the standard medicine Fluoxetine at dose of 30mg/kg and and imipramine at dose of 20mg/kg, researchers at the joint study lead by the Azad University showed that except the dose at 50mg/kg of aqueous extract, application of other doses demonstrated a linearly significant improvement of mobility times.


Further analysis also found that all doses from Anise extract increased the swimming time dose-dependently, without any significant change in climbing time in tested mice similar to those of Fluoxetine and in compared to aqueous extract.


Moreover, Fluoxetine and imipramine expressed a strong decreased immobility time in both tests in contrast to imipramine increased climbing time without any significant change in swimming time.


The result suggested that both extracts in dose higher than 50mg/kg display antidepressant-like activity similar to that of fluoxetine through improved mobility of depressed mice as inactivity is considered as one of major symptoms in patients with depression.


As the depression progressed, patients demonstrated a behavior in making efforts to escape from society, eventually will exhibit immobility with reflection of psychological despair.


Dr. Shahamat Z the lead author said, " P. anisum possesses an antidepressant-like activity similar to that of fluoxetine, which has a potential clinical value for application in the management of depression".


Additionally, in the testing essential (volatile) oil and essential oil of Piper laetispicum antidepressant activity in compared to Fluoxetine as standard antidepressant drug and other natural remedies including Leaves-Bay, Curry, Coriander and Mint; Fruits-Star anise, Pepper, Cardamom, Caraway and Fennel; Seeds of Fenugreek, Mustard, Nutmeg and Black Cumin; and Underground stem-Onion, Garlic, Ginger and Turmeric; Miscellaneous-Clove, Cinnamon, Capsicum, Tamarind and Asafoetida, reserachers found that all participated essential oil, specially anise produced a significant reduction in immobility along with an increase in climbing behavior similar to those of fluoxetine.


The application of essential oil caused a dose -dependent reduction( probably in dose less than 50 mg/kg) in immobility which is contracted to the above study and an increase in climbing at all studied doses in compared to control group.


Further more, in the examine of the efficacy of anise oil, in removing the symptoms of mild to moderate depression in patients with irritable bowel syndrome of a total of 120 randomly assigned into 3 equal groups received anise oil, Colpermin, and placebo, at the end of the study, scientists showed that application of anise group exerted a continuously improvement of the syndrome in compared to the other 2 groups with some unknown mechanisms.

Some researchers postulated that essential oil smell may have a profound effect to the brain in triggering emotional reaction in stimulating the limbic system in regulated autonomic and endocrine function, particularly, in response to emotional stimuli in expression of motivation and reinforcing behaviors.

Additionally, the application of essential oil scent also have a direct influence in calming the central nervous system in ameliorated over production of certain hormones in reacted to the unfavorably emotional behaviors.


Taken together, Anise essential oil may be used as a secondary therapy to standard medicine in treatment of depression.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Evaluation of antidepressant-like effects of aqueous and ethanolic extracts of Pimpinella anisum fruit in mice by Shahamat Z1, Abbasi-Maleki S2, Mohammadi Motamed S3.(PubMed)
(2) Effectiveness of Anise Oil for Treatment of Mild to Moderate Depression in Patients With Irritable Bowel Syndrome. A Randomized Active and Placebo-Controlled Clinical Trial by Maryam Mosaffa-Jahromi, PharmD, PhD, Ali-Mohammad Tamaddon, PharmD, PhD, Suleiman Afsharypuor, PharmD, PhD, Alireza Salehi, MD, MPH, PhD, Seyed Hassan Seradj, PharmD, PhD, Mehdi Pasalar MD, MPH, PhD, Peyman Jafari, PhD, Kamran Bagheri Lankarani, MD (Journal of Evidence-Based Integrative Medicine)
(3) Essential oil isolation from culinary drugs and screening for antidepressant potential Mohib Abdul Jalil Khan , Imtiyaz Ansari, Amjad Ali Mohammad Iqbal Oriental College of Pharmacy, Navi Mumbai, Maharashtra- 400705, India.(INTERNATIONAL JOURNAL OF ADVANCES INPHARMACY MEDICINE AND BIOALLIED SCIENCES)
(4) The Forced Swim Test as a Model of Depressive-like Behavior by Roni Yankelevitch-Yahav, 1 , 2 Motty Franko, 2 Avrham Huly, 2 and Ravid Doron(PMC)

Women's Health: How to Normalize Your Menstrual Cycle Naturally, US National Library of Medicine Studies Show

Chaste Tree berry may be used as a functional food in regulated production of progesterone in balancing steriod hormone in women menstrual cycle, some scientists suggested.


Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belongings to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Progesterone is a sex hormone with various mechanisms, including women menstrual cycle, pregnancy, embryogenesis......

According to the Royal Melbourne Institute of Technology-University, Vitex may have a function similar to the conventional medicine, fluoxetine, in stimulated production of increasing mid-luteal progesterone and 17β-oestradiol levels in women menstrual cycle.

In the review of data bases of 8 literature collection, Vitex extracts showed a significant effect in women's health.

In the aspect of premenstrual syndrome, the extract improve psychological symptoms such as depression, anxiety,... through progesterone regulation.

Dr. Deborah Brauser, author of the article of "Progesterone, Anxiety Affect Premenstrual Dysphoric Disorder" said, "As a gynecologist, I believe PMDD is driven by the female sex hormone progesterone," said Dr. Sundström Poromaa, adding that there is very little progesterone during the follicular phase".


Flavonoid glycosides, orientin and apigenin 3, 8-di-C-glycosides in addition to iridoid compound, aucubin isolated from the ethanolic extract of Vitex agnus-castus fruits, also displayed an increased production of progesterone hormone by observation of plasma progesterone of women with 0.6 and 1.2 g kg(-1) per body weight (b.w.) doses.

The study also addressed the hormone progesterone may have directed effect in increased uterine weight of ovariectomized rats in comparable to that of control group.

Dr. Jillian Stansbury, the researcher of the women herbs for men said, "Consumption of Vitex fruits by female chimpanzees as part of their natural diets has been found to dramatically increase progesterone levels in the urine, indicating an overall progesteronic effect.34 One hypothesis is that reduced LH allows follicle-stimulating hormone to dominate and can lead to decreased estrogen and testosterone and a relative increase in progesterone".


Furthermore, the contribution of the herb in improved concentration of progesterone in the luteal phase, may also increase the chance of pregnancy, as the total of 37 women with oligomenorrhea and 30 women with amenorrhea received 50 drops of Phyto Hypophyson L, a Vitex agnus castus-containing homeopathic preparation or placebo 3 times a day over 3 months or 3 cycles report.


Promisingly, intake of the Vitex agnus castus-containing homeopathic preparation expressed a spontaneous menstruation, improved concentration of progesterone in the luteal phase, shortening of the cycle, earlier ovulation, and pregnancy in 38 out of 67 women.

Taking together, chemical constituents found in Chaste tree berry expressed a strong activity in increased chance of pregnancy and normalized hormone aspects in women menstrual cycle with progesterone and other hormones regulation.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials by van Die MD1, Burger HG, Teede HJ, Bone KM.(PubMed)
(2) Progesterone, Anxiety Affect Premenstrual Dysphoric Disorder by Deborah Brauser(Medscape)
(3) Gynecological efficacy and chemical investigation of Vitex agnus-castus L. fruitsgrowing in Egypt by Ibrahim NA1, Shalaby AS, Farag RS, Elbaroty GS, Nofal SM, Hassan EM.(PubMed)
(4) WOMEN’S HERBS” FOR MEN By Editor1 Posted November 8, 2010
In Botanical Medicine, Endocrinology, Fertility, Men's Health, Nature Cure, Oncology, Dr Jillian Stansbury
(4) [The efficacy of the complex medication Phyto-Hypophyson L in female, hormone-related sterility. A randomized, placebo-controlled clinical double-blind study].[Article in German]by Bergmann J1, Luft B, Boehmann S, Runnebaum B, Gerhard I.(PubMed)

How to Prevent Onset of Pulmonary Fibrosis Naturally, MEDLINE Studies Show

Kyle J. Norton


Green tea may have a therapeutic and positive effect in reduced risk and progression and treatment of pulmonary fibrosis, some scientists suggested.

Pulmonary fibrosis (PF) is a chronic and progressive condition of lung disease characterized by reduced numbers and increased stiffness of air sac in the lungs (alveoli), affecting the lung breathing function to provide enough oxygen into the bloodstream

Green tea, is a precious drink processed numbers of health benefit known to almost everyone in Asia and Western world.

In the evaluation of green tea extract efficacy in pulmonary fibrosis caused by direct injury due to over expression of oxygen free radicals and inflammatory cells and fibroblasts in mice model with injection of Paraquat (0.3 mg/kg) into the right lungs of rats, after 2 weeks, then assigned the tested mice to group treated by green tea extract or non treatment groups and control group treated by saline, after assessment, researchers found that
* Non treatment group exerts a significant expression of pulmonary fibrosis, observed by contents of light microscopic morphometry and hydroxyproline and over capacity of ROS observed by the lipid perioxidation assay.

Light microscopic morphometry is valuable technique in the analysis of precancerous lesions at the light and electron microscopic level, in this case, it is pulmonary fibrosis.
Further examination also discovered that non treatment mice group displays a pronouncely increased
levels of malondialdehyde (MDA), an indication of over expression of free radicals in induction of oxidative stress caused by ROS chain reaction and endothelin (ET)-1, and prepro-ET-1 mRNA expression, a strong indication of the endothelium signals of vasoconstriction and local cellular growth and survival of air sac cells in the lungs (alveoli).

Malondialdehyde (MDA) is a marker of oxidative stress

Endothelin 1 (ET-1) is a potent vasoconstrictor

*In compared to non treatment and saline groups, green tea administered 1% GTE mixed with feed group shows significant decrease in pulmonary fibrosis, along with decreases in MDA, ET-1, and prepro-ET-1 mRNA expression



The result suggested that green tea inhibitorily oxidative activity in reduced expression of pulmonary fibrosis through promoted production of antioxidants and  antioxidants from the host to restore the ratio of antioxidant and free radicals and decreased the facilitation of proinflammatory cytokines in precipitated damage and apoptosis of lung cells and fibroblasts.


Dr. Kim HR, thelead author, after taking into account of other con founders said, "GTE inhibits paraquat-induced pulmonary fibrosis by suppression of oxidative stress and ET-1 expression".


Additional study of the neutrophils in the site of infection in initiated host defense and inflammation for pulmonary fibrosis development by the Medical School of Padova, revealed that application of green tea (-)epigallocatechin-3-gallate (EGCG) strongly inhibits neutrophil elastase by repressing the reactive oxygen species activity in induction of apoptosis of activated neutrophils.

In vitro, administration of EGCG dramatically inhibited chemokine expression, a secondary pro-inflammatory mediators induced by primary pro-inflammatory in activated neutrophil chemotaxis in migration of neutrophils of immune system to the site of infection.

Importantly, injection of green tea EGCG also demonstrated a significant effect by blocking neutrophil-mediated angiogenesis in vivo by initiated growth of new blood vessels to stimulate and fuel the ongoing lung cell damage and death of the cell in the alveoli.

These differentiation constituted a substantial and protective effect in enhanced resolution in a pulmonary inflammation model and significantly reduced consequent fibrosis.

Dr. Donà M, at the end of the analysis said, "These results provide molecular and cellular insights into the claimed beneficial properties of green tea and indicate that EGCG is a potent anti-inflammatory compound with therapeutic potential".


The above analysis of green tea effect in protect the lung against the development of pulmonary fibrosis caused by free radical chain reaction and over production of pro inflammatory factors were supported by the study of "the protective effect of green tea extract (GTE), curcumin, against N-acetyl cysteine (NAC) on experimentally induced pulmonary fibrosis" by Cairo University.

According to the study, application of curcumin (200 mg/kg b.w), GTE (150 mg/kg b.w), and NAC (490 mg/kg b.w) orally for 14 days with concomitant administration of cyclophosphamide (CP), revealed a strong activity in inhibited oxidative stress and lung myelo-peroxidase activity observed in animals of the CP group.

Cyclophosphamide is a chemodrug used to suppress the immune system.

Myelo-peroxidase (MPO) is a highly oxidative enzyme.

Treatment group also decreased the levels of N-acetyl-β-d-glucosaminidase, leukotriene C₄, and protein in bronchoalveolar lavage fluid (BALF) in demonstration of over reaction of immune response in induction of inflammation through inhibited production of proinflammatory cytokines (growth factor-β, interleukin -1β, and histamine) in initiated lung injure and induced apoptosis of lung cells.

N-acetyl-beta-D-glucosaminidase) in the analysis of kidney disease including nephrotoxicity.

Leukotriene C₄ is a leukotriene produced and secreted by eosinophils on activation.

Bronchoalveolar lavage fluid (BALF) is used to analyze interstitial lung diseases.

Protein abundance levels in BALF is a marker of lung diseases
 

Taken together, green tea and its bioactive polyphenols may be considered as a function food for prevention and treatment of pulmonary fibrosis through reducing oxidative stress and inflammatory effect in elevated risk and progression of the disease.

Reprint of this article is welcome with author name and link to the article sources intact https://kylejnorton.blogspot.ca/2018/03/the-magic-of-camellia-sinensis-leaves_4.html


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Neutrophil restraint by green tea: inhibition of inflammation, associated angiogenesis, and pulmonary fibrosis by Donà M1, Dell'Aica I, Calabrese F, Benelli R, Morini M, Albini A, Garbisa S.(PubMed)
(2) Green tea extract inhibits paraquat-induced pulmonary fibrosis by suppression of oxidative stress and endothelin-l expression by Kim HR1, Park BK, Oh YM, Lee YS, Lee DS, Kim HK, Kim JY, Shim TS, Lee SD(PubMed)
(3) Modulatory effects of curcumin and green tea extract against experimentally induced pulmonary fibrosis: a comparison with N-acetyl cysteine by Hamdy MA1, El-Maraghy SA, Kortam MA(PubMed)

How to Boost Your Immunity Naturally, US National Library of Medicine Studies Suggest

Kyle J. Norton

Carrots and tomatoes and theirs major bioactive carotenoids  may have a profound and positive effect in boosting immunity, some scientists suggested.

The results of the studies were carried out by numbers institutes in numbers of different differentiation, including Institute of Nutritional Physiology, Federal Research Centre for Nutrition.

You  can also view the abstract by clicking the links in the resources.

Immunity is a natural defense of organism with an aim to protect the host to resist a particular infection or toxin through expression of antibodies or sensitized white blood cells.

Carrot, a root vegetable with orange color is a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

Tomato is a red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America. 

Because of its health benefits, tomato is grown world wide for commercial purpose and often in green house.

In the investigation of the effect of beta-carotene has been shown to enhance immune functions in humans, the Institute of Nutritional Physiology, Federal Research Centre for Nutrition launched an study to examine whether vegetables rich in carotenoids, such as beta-carotene or lycopene, exert any modulation of immune function in healthy humans.

The blinded, randomized, cross-over study, included male subjects on a low-carotenoid diet consumed 330 ml/day of either tomato juice(37.0 mg/day lycopene) or carrot juice (27.1 mg/day beta-carotene and 13.1 mg/day alpha-carotene) for 2 weeks with a 2-week depletion period after juice intervention.

Epidemiological studies suggested that consuming carotenoids form food sources may provide a variety of health benefits including a reduced incidence of cancers, risk of cardiovascular disease, and improved eye health,.......

Reading of the immune status was assessed by measuring the related activity of natural killer (NK) cells, secretion of cytokines ( IL-2, IL-4, TNFalpha), and proliferation by activated peripheral blood mononuclear cells((T cells, B cells, NK cells).

Natural killer cells is a type of white blood cells formed a component of innate immune system with function in inhibited microorganisms infected cells.

Interleukin-2 (IL-2) is a type of inflammatory cytokine with function in signaling molecule in the immune system to protect the body against bacterial and viral in the acute phase of infection.

Interleukin-4 (IL-4) activated by lymphoid cells is the inflammatory cytokine critical for initiating humoral immunity against extracellular pathogens.

Both Interleukin-2 and 4 (IL-2and 4 ) play an important role in chronic inflammation and wound repair.

Tumor necrosis factor (TNF) including , tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a protein (cytokine) involved in systemic inflammation during acute phase of infection.

At the end of the experiment, researchers found that
* Both juices treated participants demonstrate relatively fast responses in plasma carotenoid concentrations (p < 0.0002) without inducing concomitant changes in immune functions.

* Intake of both tomato and carrot juice displays a significant activity of immunity in production of IL-2, NK cell cytotoxicity, and lymphocyte proliferation with maximum responses observed during depletion periods.

* In compared to the secretion of other inflammatory cytokines, TNF alpha exerts only at the end of the first intervention period.

* During the course of innervation, both juices show insignificant effects in modulated the secretion of IL-4.

These result suggested that lower plasma carotenoid concentrations in the blood stream may reduce the immune function in response to diseases caused by bacterial and viral infection, particularly in the acute phrase.

Occasional intake of tomato and carrot juice does not enhance body immunity, due to its function in time-delayed modulation of immune functions and its degradation caused by numbers of factors, including heat, light, oxygen, acid, transition metal, or interactions with radical species.

The conclusion truly addressed the important of carotenoids in modulated immune response in protection of body injure or damage during acute phrase of infection through inhibiting pro inflammatory over expression in induction of cytotoxity and damage to nearby healthy cells.

Further to reaffirm the effects of consumption of carotenoid-rich vegetables on the immune system, the Institute of Nutritional Physiology, Federal Research Centre for Nutrition conducted a study of 23 non-smokers, male subjects, who were not restricted in their daily diet, except that they had to abstain from fruit and vegetables high in carotenoids throughout the whole study period with blood collected weekly from subjects after a 12 h fast.

The study was also divided into four periods, each lasting 2 weeks: 

* Weeks 1-2: low-carotenoid period;

* Daily consumption of 330 ml tomato juice (40 mg lycopene/d, 1.5 mg beta-carotene/d) (weeks 3-4),
* 330 ml carrot juice (21.6 mg beta-carotene/d, 15.7 mg alpha-carotene/d, 0.5 mg lutein/d) (weeks 5-6)
* 10 g dried spinach powder (11.3 mg lutein/d, 3.1 mg beta-carotene/d) (weeks 7-8).

According to the assessment of T-lymphocyte and secretion of immunoreactive cytokines, lower concentration due to consumption of a low-carotenoid diet exerted a significantly reduced proliferation of function immune system observed in peripheral blood mononuclear cells (PBMC) cultured with concanavalin A.

At the end of first 2 weeks of tomato juice consumption and until the end of the intervention period, researchers found that intake of tomato juice with abundant carotenoids induced insignificant change of lymphocyte proliferation in compared to concentration at the end of the depletion period.

Similarly, the experiment also exerted a strong immune modulated effect in assessment of the secretion of cytokines binterleukin (IL)-2 and -4).

Dietary intervention improved the IL-2 and IL-4 secretion values. however the levels of IL-2 and IL-4 were significantly suppressed after the low-carotenoid diet.

The results at the end of the period also expressed the similarity of other studies " After carrot juice and spinach powder consumption the cytokine secretion capacity of PBMC was not significantly different from that at the end of the depletion period". 

Dr. Watzl B, the lead author after taking into account of other co and con founders said, " the results of the present study indicate that a low-carotenoid diet reduces T-lymphocyte functions and addition of tomato juice restores these functions". 

The unexplained changes in the plasma carotenoid concentrations, probably severed as an indication that other phytochemicals or other mechanisms in tomato and carrot juice may have a strong implication in modulated immune response other than cytokine secretion capacity of PBMC.

Taken together, tomato and carrot juice and theirs bioactive carotenoids may be considered as  functional foods in boosting immune function against foreign organsisms, particularly, in the acute phase of infection.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Supplementation of a low-carotenoid diet with tomato or carrot juice modulates immunefunctions in healthy men by Watzl B1, Bub A, Briviba K, Rechkemmer G(PubMed)
(2) Modulation of human T-lymphocyte functions by the consumption of carotenoid-rich vegetables by Watzl B1, Bub A, Brandstetter BR, Rechkemmer G.(PubMed)
(3) Factors influencing the chemical stability of carotenoids in foods by Boon CS1, McClements DJ, Weiss J, Decker EA(PubMed)