How to Prevent Leukemia Naturally and Effectively, PubMed Medical Studies Revealings

Kyle J. Norton

Adding a portion of carrots in your daily diet may have a profound and positive effect in prevent onset of leukemia, some scientists suggested.

Leukemia is progressive cancer characterized by bone marrow and other blood-forming organs in produced increased numbers of immature or abnormal leukocytes, thus suppressing the production of normal blood cells.

Leukemia is of the major cause of anemia.

The results of differentiation were conducted by several respectable universities, including Lebanese American University and Sheffield Hallam University and published on online medical literature, including Medline.

Carrot, a root vegetable with orange color is a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

Nutrients
1. Carbohydrates
2. Sugars
3. Fibre
4. Fat
5. Protein
6. Vitamin A
7. Thiamine (VittaminB1)
8. Riboflavin (Vittamin B2)
9. Niacin (Vittamin B3)
10. Vitamin B6
11. Folate (Vittamin B9)
12. Vitamin C
13. Vitamin K
14. Calcium
15. Iron
16. Magnesium
17. Molybdenum
18. Phosphorus
19. Potassium
20. Sodium

In the evaluation of the effect of Daucus carota oil extract (DCOE) in target acute myeloid leukemia (AML) cell lines, researcher at the Lebanese American University, found that application of carrot extract exerts a significant activity in inhibited all the AML cell lines while expressing no effect in tested peripheral mononuclear cells.

Peripheral blood mononuclear cells (PBMC) are blood cells with round nuclei formed an important part of immune system components, including lymphocytes (T cells, B cells and NK cells) and monocytes. The mononuclear cells are commonly used in research on immune disorders, cancer and viral diseases.......

The inhibition of AML cell death observed by annexinV found that application of carrot oil extract restored the viability of healthy cells found in the acute myeloid leukemia (AML) cell lines but induces apoptotic cell death in AML through cytotoxicity

Dr. Tawil M, the lead scientist said, "DCOE induces selective apoptosis in AML cells, possibly through a MAPK-dependent mechanism".

Mitogen-activated protein kinases (MAPKs) are family of serine/threonine protein kinases with strong effect in regulated cellular processes such as proliferation, differentiation, motility, stress response, apoptosis, and survival.

In further confirmation of carrot effect in inhibited leukaemia, five fractions from carrot juice extract (CJE) were tested on human lymphoid leukaemia cell lines, including 3 polyacetylenes (falcarinol, falcarindiol and falcarindiol-3-acetate) and 2 carotenoids (beta-carotene and lutein).

According to the Annexin V/PI and Caspase 3 activity assays and Cell Titer Glo assay and cell cycle analysis,
* Injection of carrot extracts which contained polyacetylenes and carotenoids was significantly more cytotoxic in all three lymphoid leukaemia cell linesthan the 4 other fractions.

* Treatments with purified polyacetylenes also induced apoptosis in a dose and time responsive manner.

* Falcarinol and falcarindiol-3-acetate isolated from Daucus carota L were more cytotoxic in compared to falcarindiol

* Interestingly, the carotenoids treatment showed no significant effect on either apoptosis or proliferation in any of the tested cell lines.

These results suggested that carrot processed anti leukemia through induction of cell apoptosis via cytotocity and cell cycle arrest was attributed to the contents of polyacetylenes rather than beta-carotene or lutein.

Additionally, in the study of carrot juice extract effect against leukemia cells, researchers at the Sheffield Hallam University found that on myeloid and lymphoid leukemia cell lines together with normal hematopoietic stem cells, injection of carrot juice extracts to 72 hours induces apoptosis and inhibited progression through the cell cycle.

In classification of types of cell line, also indicated that lymphoid cell lines are affected to a greater extent in compared to myeloid cell lines. Application of the extract showed no effect on normal hematopoietic stem cells.

The experiment strongly suggested that carrot juice extract significantly induces apoptosis and causes cell cycle arrest in leukemia cell lines without harming to the healthy nearby cells.

Taken together, carrot and its extract may be considered as potent and therapeutic therapies for prevention of leukemia.

However, intake of carrot supplement should be taken with extreme care in prevention of acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Effects of bioactive compounds from carrots (Daucus carota L.), polyacetylenes, beta-carotene and lutein on human lymphoid leukaemia cells by Zaini RG1, Brandt K, Clench MR, Le Maitre CL.(PubMed)
(2) Bioactive chemicals from carrot (Daucus carota) juice extracts for the treatment of leukemia.
Zaini R1, Clench MR, Le Maitre CL(PubMed)

(3) Wild carrot oil extract is selectively cytotoxic to human acute myeloid leukemia cells BY Tawil M1, Bekdash A, Mroueh M, Daher CF, Abi-Habib RJ.(PubMed)

How to Protect Yourself From Spring Allergies Naturally, Medline Health Studies Findings

Kyle J. Norton


Including a portion of fennel in your daily diet may improve the body anti-allergic activities, some scientists suggested.

The results of the differentiation were carried out by numbers of universities and published on online medical literature.

Allergic effect associated to non harmful allergens caused by over reaction of immune system may induce symptoms of skin rash, sneezing,....

In some cases, allergic reaction can be life-threatening (anaphylaxis), depending to severity of immune responses.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.



In the study to confirm the potential efficacy of fennel for antiallergic use, inhibitory actions of the fruiton 5-lipoxgenase (5-LOX) and β-hexosaminidase release, researchers found that application of fennel extract at ethanol 70% with IC50 of  3.2 μg/ml, exerts a potential effect in inhibited 5-LOX-catalyzed leukotriene production in mediation of allergy, and other immune responses.

β-hexosaminidase released from activated mast cells are responsible for the allergic inflammatory reactions associated with immune response.

5-Lipoxygenase (5-LOX), a enzyme plays important roles in infection and allergic responses.

Although many ingredients isolated from fennel fruit demonstrated an inhibitory effect in reduced immune over reaction of the unharmful allergens, phenylpropanoid, trans-anethole, showed considerable inhibitory action of 5-LOX in compared to others, particularly at IC50 of 51.6 μM of trans-anethole


However, the fennel bioactive compound tran-anethole displayed insignificant effect on the degranulation reaction of β-hexosaminidase release from antigen-treated RBL-2H3 cells in compared to other ingredients.

RBL-2H3 cell line, is a commonly used histamine-releasing cell line in immunological research of.inflammatory and allergic activities.

These results suggested, depending to the stimulation of allergens, fennel demonstrated anti anti allergic activity through expression of different constituents in both the plant (FR) and trans-anethole alone. 

Dr. the lead author after taking into account of other co founders, said, " FR and several major constituents are 5-LOX inhibitors and they may have potential for treating 5-LOX-related disorders".

Additionally, according to the study of Yonsei University, oral administration (200 mg/kg) of Foeniculum vulgare fruit methanolic extract in tested animal model exhibited inhibitory effects against acute and subacute inflammatory diseases and type IV allergic reactions, an delayed type hypersensitivity usually takes a few days to develop.

Further analysis suggested that application of fennel also reduced inflammatory factors activated by

immune response in induction of systemic inflammation against allergens in causing damage to the body through its antioxidants and stimulated productions of antioxidant enzymes from the host, such as  superoxide dismutase (SOD) and catalase and the high density lipoprotein-cholesterol level.in prevention of lipid peroxidation in initiated by ROS.

Moreover, the application also reduced levels of malondialdehyde (MDA), which is an indication and maker of oxidative stress.

Interestingly, F. vulgare fruit methanolic extract expressed a strong effect in inhibition of nitric oxide (NO) produced by the innate immune system through activated macrophages in  inhibited pathogens replication.

The above differentiation were supported by the literature of "Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology"

posted in the BioMed Resreach International.

According to the study, oral injection of methanolic extract of F. vulgare fruit at200 mg/kg once a day for 7 days showed an significant inhibitory effect on DNFB- (2,4-dinitrofluorobenzene-) induced delayed type hypersensitivity  through fennel immunosuppressive properties.

2,4-dinitrofluorobenzene (DNFB) may induce allergy contact dermatitis.

The information collected indicated that fennel, its bioactive compounds and extracts may be considered as a functional food for reduced risk immune over response to unharmful allergens.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) 5-Lipoxygenase Inhibition of the Fructus of Foeniculum vulgare and Its Constituents by Lee JH1, Lee DU, Kim YS, Kim HP.(PubMed)
(2) Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare by Choi EM1, Hwang JK.(PubMed)
(3) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)

How to Prevent Cancers Naturally and Efficaciously, Medline Studies Revealings

Kyle J. Norton

Adding a portion of Dried Beans into your diet, may have a potential effect in reduced risk of cancers, according to the Division of Cancer Prevention, National Cancer Institute.

Dried beans are nutritionally mighty member of the legume family, belongings to the family Fabaceae with healthy source of proteins, fibers, vitamins and minerals.

In the study to investigate 490,802 United States participants of the NIH-AARP Diet and Health cohort using Cox proportional hazard models adjusted for potential confounders and during 2,193,751 person years of follow-up from 1995/1996-2000, researchers found that
*. Intake of vegetables showed a significant effect in reduced risk of certain types of cancer.

* The relative hazard ratio risk of cancer was reduced to .95 in compared to control

*. Risk of cancer was reduced substantially as shown in highest tertile of leguminosae group (dried beans, string beans and peas, 0.80, 0.67-0.96) in compared to other groups.

Dried bean and string bean with abundant fiber scored the lower and lowerest relative risk ratio in compared to peas and other kinds of vegetables

Further analysis of diets of African-American men and women, undergoing colonoscopies in order to examine the relationship between selected dietary factors and the risk for colon polyps, according to the multiple logistic regression model used to adjust for potential confounding variables and to determine which factors influence colorectal adenoma risk, researchers said, " consumption of legumes such as dried beans, split peas, or lentils was negatively associated with risk (OR = 0.19; 95% CI: 0.04-0.91)." and "Legumes are a good source of dietary fiber and of phytochemical compounds that may play a role in reducing adenoma formation or growth".

Once again, dried beans exerted a highest effect in reduced risk of colorectal adenoma in compared to other types of legume.

Interestingly, in broaden scope of further explore the association between legume intake and cancer risk in a case-control study of 11 cancer sites in Uruguay between 1996 and 2004, including 3,539 cancer cases and 2,032 hospital controls, intake of legume including dried peas, expressed a substantially decreased risk of stomach and prostate cancer and other forms of cancer, including
*. Cavity and pharynx cancer had a relative odd risk ratio of OR=0.48

*. Esophagus cancer with OR = 0.54

*. Larynx cancer with OR = 0.55

*. Upper aerodigestive tract cancer with OR = 0.50

*. Stomach cancer with OR = 0.69

*. Colorectum cancer with OR = 0.43

*. Kidney cancer relative had odd risk ratio of .OR = 0.41

* With relative odd risk ratio of .68 on all sites combined


After adjusting to other risk factors researchers concluded, "Higher intake of legumes was associated with a decreased risk of several cancers including those of the upper aerodigestive tract, stomach, colorectum, and kidney, but not lung, breast, prostate or bladder".


Taking altogether, there is no doubt that legume, including dried beans may have a strong effect in reduced risk of cancers excluding cancers of lung, breast, prostate and. bladder.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca




Sources
(1) Legume intake and the risk of cancer: a multisite case-control study in Uruguay by Aune D1, De Stefani E, Ronco A, Boffetta P, Deneo-Pellegrini H, Acosta G, Mendilaharsu M.(PubMed)
(2) Legume intake and reduced colorectal adenoma risk in African-Americans by Agurs-Collins T1, Smoot D, Afful J, Makambi K, Adams-Campbell LL.(PubMed)
(3) Fruit and vegetable intake and head and neck cancer risk in a large United States prospective cohort study by Freedman ND1, Park Y, Subar AF, Hollenbeck AR, Leitzmann MF, Schatzkin A, Abnet CC.(PubMed)

How to Cure Impetigo Naturally With No Adverse Effects, US National Library of Medicine Studies Suggestions

Kyle J. Norton

Green tea or tea lotion may have a therapeutic and positive effect better than conventional medicine Framycetin and Cephalexin gramicidin (soframycin) in treatment of impetigo, some scientists suggested.

The disease investigation was differentiated by numbers of institutes including Baghdad University and the results of the studies were published on online literature.

You can view the abstract of studies from PubMed, by clicking any of the resources' link.

Impetigo is a skin condition caused by bacterial skin infection with symptoms of blisters and sores,
around the nose and mouth, and on the arms or legs. In some case, it may appear in the facial area.

The disease infects mostly children.

In differentiated the effect of tea lotion against impetigo infected by bacteria, researchers at the Baghdad University conducted a study with participated of a total of 104 patients, including 47 females (45.2%) and 57 males (54.8%) with ages ranged from one month to 40 years with a median of 4 years.

Patients were randomly assigned to treatment group with green tea applied to the infected areas and control group.

According to the diagnosis from the swabbed collected from patients, and analysed by microbiology impetigo contagiosa, pure S. aureus and combination of S. aureus and Streptococcus pyogenes were presented in 94.3% and 5.7% respectively in all patients.

These results suggested that  the prevalent risk of impetigo is mostly caused by infection of S. aureus.

Application tea lotion, including green tea, demonstrated a significant effect in reduced infectious areas substantially with successfully cured rate of of 81.3% in compared to control non treatment group.

In examine the 40 patients in control group further  assigned to 2 groups received either an ointment containing Framycetin or gramicidin (soframycin), researchers found that Framycetin and cephalexin gramicidin (soframycin) exerted a potential a cure rate of  only 72.2% and 78.6%, respectively.

The results suggested that tea ointment or lotion displayed a better effect in treating impetigo in compared to conventional medicine Framycetin and gramicidin (soframycin) without inducing any adverse effects.

Dr. Sharquie KE, after taking into account of other co and con founders said "(tea lotion) demonstrated the anti-bacterial action of crude tea in vivo, against impetigo contagiosa". 

In further evaluation of green tea effect in reduced prevalence of skin infection, researchers at the Oakland University William Beaumont School of Medicine Rochester showed that catechins found in green tea have shown  promise for having antimicrobial effects, particular in fractions of (-)-epicatechin (EC), (-)-epicatechin-3-gallate (ECG), (-)-epigallocatechin (EGC), and (-)-epigallocatechin-3-gallate (EGCG).

Researchers continued, application of green tea bioactive catechin exhibited a variety of antimicrobial mechanisms and may be considered as a potential for preventive and therapeutic purposes.

In fact, relatively low concentrations of ECG was found to sensitize methicillin-resistant S. aureus (MRSA) clinical isolates to levels of oxacillin.

And, Catechin gallates such as ECG also showed to intercalate into phopsholipid bilayers, affecting both virulence and antibiotic resistance by perturbing the function of bacterial process of invasion.

The results may be attributed to green tea effect in reduced key processes associated with the bacterial cytoplasmic membrane.

However, further data collection on studies performed with human consumption during the course of infections, and studies on the occurrence of infections in populations that consume regular amounts of green tea will be necessary to complete the picture of its antimicrobial possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The antibacterial activity of tea in vitro and in vivo (in patients with impetigo contagiosa).
Sharquie KE1, al-Turfi IA, al-Salloum SM.(PubMed)

(2) Antimicrobial properties of green tea catechins by Taylor PW1, Hamilton-Miller JM, Stapleton PD.(PubMed)

(3) The antimicrobial possibilities of green tea by Reygaert WC1.(PubMed)

How To Free the Body From Toxins Accumulation Naturally and Permanently, Medline Model Studies Suggestions

Kyle J. Norton

Adding portion of fennel to your diet daily may have a potential and positive effect in getting risk of excess water and toxins from body, some scientists suggested.

The results were reported on online medical literature conducted by some respectable institutes, including John Wiley & Sons, Ltd . and UFR Physiologie-Pharmacologie over different aspects.

Diuresis is a medicine in the stimulation of increased production of urine.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.


In animal model, according to the John Wiley & Sons, Ltd. in the evaluation of the retoxic effect of ydroalcohol extracts of Foeniculum vulgare var dulce (D.C) root, application of the extract exerted  significant activities in flushing out of excess water and toxin from body through increased kidney function in secretion of the urine.

The results of these properties were observed by an increase in urine flow and urinary sodium excretion.

The efficacy in cleansing body was also found linearly in dose depending manner.

Continuously, in further examine the efficacy of fennel powder, extract and oil on gentamicin induced nephrotoxicity through an study of total 35 adult female sprague Dawley rats classified into five groups with first group kept on standard diet all over the period of the experiment. and the other groups administered gentamicin (100 mg/kg/day for 7 days i.p), followed by either control (+ve) group or treated groups with fennel powder, extract and oil for 45 days, at the end of study, researchers found that
* Injected gentamicin group served as control exhibits a strong nephrotoxicity manifested by increase levels of kidney function indicator, serum nitric oxide (NO) and kidney malondialdyde (MDA) however, this group of rats also exerted a significant decrease in weight gain.

Increased expression of serum nitric oxide (NO) and kidney malondialdyde (MDA) is an indicators of severed oxidative stress caused by imbalanced of ration of ROS and antioxidants in the host.


* Gentamicin groups treated with fennel powder, extract and oil demonstrated an improve the levels of urea and uric acid in comparing to control (+ve) and displayed an improvement of antioxidant enzymes as increase of serum superoxide dismutase(SOD), catalase, and glutathione transferase (GST) and decrease of serum NO in compared to control (+ve) group.


These results addressed the important antioxidant effect of fennel extracts. the applications not only inhibited the levels of free radical and theirs' chain reactive activities but also stimulated production of antioxidants found in the host tissue.


* Moreover, group treated with fennel oil restored the normal values of kidney antioxidant enzymes compared with normal group and other treatment groups.


Dr. Soheir Ahamed Al-Masri, the lead author, after taking into account of other co and con founders said, "fennel powder, extract and oil have a potent antioxidant and ameliorate in rats gentamicin induced nephrotoxicity in rats".


Clearly, fennel oil exhibited the greatest effect in stimulated kidney function in detox the body toxins through increased secretion of urine in compared to other experimental groups.


The results of this study clearly indicated that fennel powder, extract and oil have a potent antioxidant and ameliorate in rats gentamicin induced nephrotoxicity in rats. [Soheir Ahamed Al-Masri and Waffa, Sh. Ali. The Ameliorating

Interestingly, in spontaneously hypertensive rats (SHR) treated with either water extract of Marrubium vulgare L. or Foeniculum vulgare L. in normotensive Wistar-Kyoto rats (WKY), researchers showed that application of fennel water extract reduces hypertension through Foeniculum increased water, sodium and potassium excretion in compared to non effect of Marrubium treated group.

Additionally, in compared to Marrubium extract in reduced hypertenion through inhibited contractile responses, fennel restored the normal; blood pressure by increased urine secretion and ameliorated the over expression of ROS and increased antioxidant status in the tested rats.

Surely, one can says that Foeniculum acts mainly as a diuretic and a natriuretic while Marrubium displays vascular relaxant activity.


Taken together, fennel and its extracts may be considered as a detox functional food in getting rid of body toxins through its diuretic activities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Diuretic action of hydroalcohol extracts oilFoeniculum vulgare var dulce (D.C.) roots in rats by
D. Beaux, J. Fleurentin and F. Mortier(Wiley Online Library)
(2) The Ameliorating Effects of Fennel Powder, Extract and Oil on Gentamicin Induced Nephrotoxicity in Rats 1 Soheir Ahamed Al-Masri and 2 Waffa, Sh. Ali( Journal of American Science)
(3) Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat by El Bardai S1, Lyoussi B, Wibo M, Morel N.(PubMed)

How to Improve Vascular Function Naturally and Permanently In Prevention of Heart Disease, National Institutes of Health Studies Suggestions

Kyle J. Norton


Intake of nitrate-rich beetroot juice may have a substantial and profound effect in improved vascular function, thus reducing risk of heart disease.

Beet, best known as the beetroot or garden beet is a perennial plant with leafy stems growing to 1–2 m tall, belonging to the amaranth family.

Vascular function are bundle vascular system with function in blood circulation.

Abnormal vascular function is considered as one of the risk factor in development of heart disease.

In a total of 69 subjects recruited in this randomized, double-blind, placebo-controlled parallel study to examine the change in vascular function induced by intake of Nitrate-Rich Beetroot Juice, determined with the use of ultrasound flow-mediated dilatation (FMD).

The flow-mediated dilation (FMD).test, an ultrasound technique performed only by a skilled sonographer is a noninvasive assessment of vascular endothelial function through experts understanding of the physiology, analysis, and interpretation of this measurement

Intake of nitrate-rich beetroot juice displayed a significant increase in the FMD response of 1.1% in compared to placebo group of decrease of 0.3%

Nitrate-rich beetroot juice group also demonstrated a small improvement of stiffness measured by Aortic Pulse Wave Velocity and showed a trend of continuous improvement in compared to placebo.

Aortic Pulse Wave Velocity is a test to measure stiffness of the largest artery in the body, Increased stiffness will result in reduced mobility in related regions.


Result of aortic pulse wave velocity measurement is said to have an ability to identify people in their 20’s who are at increased risk for development of heart disease, stroke and dementia.


Administration of nitrate-rich beetroot juice showed a strong reduction of 7.6% of platelet-monocyte aggregates in compared to increase of 10.1% in placebo. This finding indicated that nitrate-rich beetroot juice intake had a substantial effect in decreased risk of acute myocardial infarction.

Platelet–monocyte aggregates is a novel index with platelet activation and a maker of early onset of acute myocardial infarction.


Furthermore, intake of nitrate-rich beetroot juice group expressed an exceptional improvement of vascular function in reduced P-selectin expression in activated platelet aggression

P-selectin is a cell adhesion molecule (CAM) with function in mediated the interaction of activated endothelial cells or platelets.


Additionally, application of the juice also improved the nonpathogenic, commensal bacteria present in the healthy human salivary glands measured by salivary microbiome in compared to placebo group.


Interestingly, intake of the nitrate-rich beetroot juice also responded to change of 78 bacterial taxa out of thousands harbored in human gut.


The proportions of Rothia mucilaginosa trending to increase in nitrate-rich beetroot juice group, in compared to Neisseria flavescens (P < 0.01) increased in the placebo group.


Rothia mucilaginosa, is considered part of the normal microflora of the human mouth and the upper respiratory tract.

Neisseria flavescens is an uncommon pathogen of human infection, pneumonia and empyema


There were no adverse effects of dietary nitrate were detected through out the experiment.

The finding evidences suggested that intake of nitrate-rich beetroot juice daily may have a sustainable effect in improve vascular function, thus reducing risk of heart disease.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study by Velmurugan S1, Gan JM1, Rathod KS1, Khambata RS1, Ghosh SM1, Hartley A1, Van Eijl S1, Sagi-Kiss V2, Chowdhury TA3, Curtis M4, Kuhnle GG2, Wade WG5, Ahluwalia A6(PubMed)

How to Modulate Progression of Parkinson's disease (PD) Naturally and Effectively, PubMed Health Studies Explanations

Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)


Green tea may be considered as a functional food and iron chelator in modulated progression of Parkinson's disease, some scientists suggested

Iron chelation therapy is a primary and standard treatment for patients with iron overload.

Green tea, is a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Parkinson's disease (PD) is a progressive neurodegenerative disease, caused by basal ganglia degeneration in induced severe depletion of glutamatergic, dopaminergic and γ-aminobutyric acid (GABA) homeostasis inputs in the striatum, resulting in over expression of iron.
Monoaminergic systems and glutamate and γ-aminobutyric acid (GABA) homeostasis are vital for iron metabolism.

Investigation of the green tea (−)-epigallocatechin-3-gallate (EGCG) effect in risk and progression of PD has been associated to many mechanisms involved numbers of aspects.


Application of metal chelation was found to ameliorate the expression of ROS in induction of oxidative stress through a chain of reaction and precipitation of aggregation of alpha-synuclein and beta-amyloid peptides deposit in the brain, a main cause on the onset of PD.


In iron abnormality PD subjects, oxidopamine, also known as 6-hydroxydopamine or 2,4,5-trihydroxyphenethylamine(6-OHD), a neurotoxic synthetic organic compound was found to disrupt iron metabolism, leading to over expression of the iron in induction of dyshomeostasis cause of iron toxicity and oxidative damage in dopaminergic neurons.


Green tea major polyphenol, (−)-epigallocatechin-3-gallate used in metal chelation, ameliorated iron dependent free radicals located in the subcellular compartments and cellular membranes, through the effect in inhibited iron input and exhibited iron output in brain areas where it preferentially accumulates in neurodegenerative diseases, particularly Parkinsons' disease.


Further analysis of the neurotoxin 6-OHDA causes of iron unstable equilibrium, green extract GECG administration improved the function of hepcidin, a liver-derived hormone in regulated iron dyshomeostasis and gene expression of the iron metabolism through expressions of iron regulatory proteins (IRP1 and IRP2) in regulated the RNA level, between the transcription and the translation of the gene in expression of the iron homeostasis.


Indeed, in the differentiation of neurotoxin 6-OHDA induced iron dyshomeostasis in increased oxidative stress in damage to neuron cells, green extract EGCG effects demonstrated a significant inhibition of free radical and iron free radical expression in the cellular membranes through the antioxidant activities and anti-inflammatory system and expression of nuclear factor-like 2(Nrf2) in stimulated production of antioxidant in protection against oxidative damage during injury and inflammation and increased production of superoxide dismutase and catalase against ROS and peroxisome proliferator-activated receptor gamma (PPARγ) in regulated production of pro and anti inflammatory cytokines and mytokines..

By reducing the over expression of oxidative damage to neuron cells through regulation of iron related factors as mentioned above, iron chelator EGCG can counteract these adverse effects of iron overload in prevented onset of PD.


Further study of the mechanism on disruption of iron metabolism by 6-OHDA in PD cell line N27, discovered that application of the iron chelator EGCG also disrupts the iron dyshomeostasis in N27 cells (dopaminergic neural cell line) induced by 6-OHDA through regulating iron transporters and regulators expression, such as DMT1 with function in mediation of the entry of dietary iron into these mucosal cells and TfR, a carrier protein for transferrin with function in import iron into the cell and regulated response to intracellular iron concentration and hepcidin, a central regulator in maintain iron homeostasis.

Dysregulation of hepcidin production results in a variety of iron disorders.


Additionally, in 6-OHDA induced neurotoxicity to cause PD, administration of green tea EGCG also reduced the intracellular iron retention by decreasing the iron importers and increasing iron exporters, through regulation of the function of iron-regulated transporters, such as ferroportin.


Interestingly, there was a report suggested that intervention of 3 cups of green tea daily for 3 months improved the antioxidant status and reduced oxidative damage in early PD patients without affecting their iron status.

The findings revealed that green tea bioactive polyphenol, (−)-epigallocatechin-3-gallate may be considered as iron chelator in regulation of PD progression.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Neuroprotective Properties of the Standardized Extract from Camellia sinensis (Green Tea) and Its Main Bioactive Components, Epicatechin and Epigallocatechin Gallate, in the 6-OHDA Model of Parkinson's Disease by Bitu Pinto N1, da Silva Alexandre B2, Neves KR3, Silva AH3, Leal LK3, Viana GS1.(PubMed)
(2) Green tea polyphenols prevent Parkinson's disease: in vitro and in vivo studies Dan Chen by Iowa State University