How to Improve Vascular Function Naturally and Permanently In Prevention of Heart Disease, National Institutes of Health Studies Suggestions

Kyle J. Norton


Intake of nitrate-rich beetroot juice may have a substantial and profound effect in improved vascular function, thus reducing risk of heart disease.

Beet, best known as the beetroot or garden beet is a perennial plant with leafy stems growing to 1–2 m tall, belonging to the amaranth family.

Vascular function are bundle vascular system with function in blood circulation.

Abnormal vascular function is considered as one of the risk factor in development of heart disease.

In a total of 69 subjects recruited in this randomized, double-blind, placebo-controlled parallel study to examine the change in vascular function induced by intake of Nitrate-Rich Beetroot Juice, determined with the use of ultrasound flow-mediated dilatation (FMD).

The flow-mediated dilation (FMD).test, an ultrasound technique performed only by a skilled sonographer is a noninvasive assessment of vascular endothelial function through experts understanding of the physiology, analysis, and interpretation of this measurement

Intake of nitrate-rich beetroot juice displayed a significant increase in the FMD response of 1.1% in compared to placebo group of decrease of 0.3%

Nitrate-rich beetroot juice group also demonstrated a small improvement of stiffness measured by Aortic Pulse Wave Velocity and showed a trend of continuous improvement in compared to placebo.

Aortic Pulse Wave Velocity is a test to measure stiffness of the largest artery in the body, Increased stiffness will result in reduced mobility in related regions.


Result of aortic pulse wave velocity measurement is said to have an ability to identify people in their 20’s who are at increased risk for development of heart disease, stroke and dementia.


Administration of nitrate-rich beetroot juice showed a strong reduction of 7.6% of platelet-monocyte aggregates in compared to increase of 10.1% in placebo. This finding indicated that nitrate-rich beetroot juice intake had a substantial effect in decreased risk of acute myocardial infarction.

Platelet–monocyte aggregates is a novel index with platelet activation and a maker of early onset of acute myocardial infarction.


Furthermore, intake of nitrate-rich beetroot juice group expressed an exceptional improvement of vascular function in reduced P-selectin expression in activated platelet aggression

P-selectin is a cell adhesion molecule (CAM) with function in mediated the interaction of activated endothelial cells or platelets.


Additionally, application of the juice also improved the nonpathogenic, commensal bacteria present in the healthy human salivary glands measured by salivary microbiome in compared to placebo group.


Interestingly, intake of the nitrate-rich beetroot juice also responded to change of 78 bacterial taxa out of thousands harbored in human gut.


The proportions of Rothia mucilaginosa trending to increase in nitrate-rich beetroot juice group, in compared to Neisseria flavescens (P < 0.01) increased in the placebo group.


Rothia mucilaginosa, is considered part of the normal microflora of the human mouth and the upper respiratory tract.

Neisseria flavescens is an uncommon pathogen of human infection, pneumonia and empyema


There were no adverse effects of dietary nitrate were detected through out the experiment.

The finding evidences suggested that intake of nitrate-rich beetroot juice daily may have a sustainable effect in improve vascular function, thus reducing risk of heart disease.


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Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study by Velmurugan S1, Gan JM1, Rathod KS1, Khambata RS1, Ghosh SM1, Hartley A1, Van Eijl S1, Sagi-Kiss V2, Chowdhury TA3, Curtis M4, Kuhnle GG2, Wade WG5, Ahluwalia A6(PubMed)

How to Modulate Progression of Parkinson's disease (PD) Naturally and Effectively, PubMed Health Studies Explanations

Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)


Green tea may be considered as a functional food and iron chelator in modulated progression of Parkinson's disease, some scientists suggested

Iron chelation therapy is a primary and standard treatment for patients with iron overload.

Green tea, is a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Parkinson's disease (PD) is a progressive neurodegenerative disease, caused by basal ganglia degeneration in induced severe depletion of glutamatergic, dopaminergic and γ-aminobutyric acid (GABA) homeostasis inputs in the striatum, resulting in over expression of iron.
Monoaminergic systems and glutamate and γ-aminobutyric acid (GABA) homeostasis are vital for iron metabolism.

Investigation of the green tea (−)-epigallocatechin-3-gallate (EGCG) effect in risk and progression of PD has been associated to many mechanisms involved numbers of aspects.


Application of metal chelation was found to ameliorate the expression of ROS in induction of oxidative stress through a chain of reaction and precipitation of aggregation of alpha-synuclein and beta-amyloid peptides deposit in the brain, a main cause on the onset of PD.


In iron abnormality PD subjects, oxidopamine, also known as 6-hydroxydopamine or 2,4,5-trihydroxyphenethylamine(6-OHD), a neurotoxic synthetic organic compound was found to disrupt iron metabolism, leading to over expression of the iron in induction of dyshomeostasis cause of iron toxicity and oxidative damage in dopaminergic neurons.


Green tea major polyphenol, (−)-epigallocatechin-3-gallate used in metal chelation, ameliorated iron dependent free radicals located in the subcellular compartments and cellular membranes, through the effect in inhibited iron input and exhibited iron output in brain areas where it preferentially accumulates in neurodegenerative diseases, particularly Parkinsons' disease.


Further analysis of the neurotoxin 6-OHDA causes of iron unstable equilibrium, green extract GECG administration improved the function of hepcidin, a liver-derived hormone in regulated iron dyshomeostasis and gene expression of the iron metabolism through expressions of iron regulatory proteins (IRP1 and IRP2) in regulated the RNA level, between the transcription and the translation of the gene in expression of the iron homeostasis.


Indeed, in the differentiation of neurotoxin 6-OHDA induced iron dyshomeostasis in increased oxidative stress in damage to neuron cells, green extract EGCG effects demonstrated a significant inhibition of free radical and iron free radical expression in the cellular membranes through the antioxidant activities and anti-inflammatory system and expression of nuclear factor-like 2(Nrf2) in stimulated production of antioxidant in protection against oxidative damage during injury and inflammation and increased production of superoxide dismutase and catalase against ROS and peroxisome proliferator-activated receptor gamma (PPARγ) in regulated production of pro and anti inflammatory cytokines and mytokines..

By reducing the over expression of oxidative damage to neuron cells through regulation of iron related factors as mentioned above, iron chelator EGCG can counteract these adverse effects of iron overload in prevented onset of PD.


Further study of the mechanism on disruption of iron metabolism by 6-OHDA in PD cell line N27, discovered that application of the iron chelator EGCG also disrupts the iron dyshomeostasis in N27 cells (dopaminergic neural cell line) induced by 6-OHDA through regulating iron transporters and regulators expression, such as DMT1 with function in mediation of the entry of dietary iron into these mucosal cells and TfR, a carrier protein for transferrin with function in import iron into the cell and regulated response to intracellular iron concentration and hepcidin, a central regulator in maintain iron homeostasis.

Dysregulation of hepcidin production results in a variety of iron disorders.


Additionally, in 6-OHDA induced neurotoxicity to cause PD, administration of green tea EGCG also reduced the intracellular iron retention by decreasing the iron importers and increasing iron exporters, through regulation of the function of iron-regulated transporters, such as ferroportin.


Interestingly, there was a report suggested that intervention of 3 cups of green tea daily for 3 months improved the antioxidant status and reduced oxidative damage in early PD patients without affecting their iron status.

The findings revealed that green tea bioactive polyphenol, (−)-epigallocatechin-3-gallate may be considered as iron chelator in regulation of PD progression.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Neuroprotective Properties of the Standardized Extract from Camellia sinensis (Green Tea) and Its Main Bioactive Components, Epicatechin and Epigallocatechin Gallate, in the 6-OHDA Model of Parkinson's Disease by Bitu Pinto N1, da Silva Alexandre B2, Neves KR3, Silva AH3, Leal LK3, Viana GS1.(PubMed)
(2) Green tea polyphenols prevent Parkinson's disease: in vitro and in vivo studies Dan Chen by Iowa State University

How to Prevent Cardiovascular Disease(CVD) Naturally and Easily, Medline Studies Showed

By Kyle J. Norton

Black or common bean may be considered as function foods in attenuated risk of Cardivascular disease, a renowned institute postulated.

Cardiovascular disease is a condition of heart attack caused by block of blood in vessel as a result of narrowing and hardening of blood vessels.

Black bean, a small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms.

It is believed that black bean was first domesticated growth in South America.

According to the University of Colorado Colorado Springs, individuals who eat more bean in promoted less glycaemic stress (hyperglycaemia and hyperinsulinaemia) may have a reduced risk of CVD,

The study also addressed the importance of bean efficacy on glycaemic response and the impact of that relationship may have on the risk of developing diabetes and CVD.

In Sprague-Dawley rats model and C57Bl/6 mice induced obesity by a diet, both bean diet,groups showed a significant in reduced plasma total cholesterol and LDL-cholesterol without affecting HDL-cholesterol or total TAG in short-term. And bean-fed obese mice not only induced weight loss but also improved plasma lipid profile within a 12 d time frame in compared to other groups.

The weight loss and reduced levels of blood cholesterol in tested subjects provided a significant information of bean function in ameliorated risk of cardiovascular disease.


Other in the study of risk of development of cardiovascular complications in patients with diabetes, suggested that the imbalance between reactive oxygen species and antioxidant systems in patients with types 2 diabetes may be the leading causes of heart complications involving high cardiac collagen content.

Therefor, increased intake of bean diet may play a prevalent role in reduced risk of CVD by increased total antioxidant activity and decreased the expression of hyperglycaemic state, catalase and superoxide dismutase activity and tissue damage caused by lipid peroxidation.


Dr. Oliveira RJ, the lead author said, "The phaseolamin treatment attenuated the collagen levels compared to non-treated diabetic rats. Thus, the short-term anti-hyperglycaemic effect of the phaseolamin treatment may prevent the initial changes caused by oxidative stress and the deposition of collagen, as well as reduce the incidence of heart complications".


Collectively, adding a bean portion in your diet daily may have a substantially reduced risk of heart disease and heart complications in diabetics, in comparison to people with typical American diet.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Phaseolus beans: impact on glycaemic response and chronic disease risk in human subjects by Hutchins AM1, Winham DM, Thompson SV.(PubMed)
(2) Edible dry bean consumption (Phaseolus vulgaris L.) modulates cardiovascular risk factors and diet-induced obesity in rats and mice by Zhu Z1, Jiang W, Thompson HJ.(PubMed)
(3) Phaseolamin treatment prevents oxidative stress and collagen deposition in the hearts of streptozotocin-induced diabetic rats by Oliveira RJ1, de Oliveira VN, Deconte SR, Calábria LK, da Silva Moraes A, Espindola FS.(PubMed)

How To Treat Inflammatory Diseases Effectively and Naturally, PubMed Studies Suggestions

Arnica essential oil and major phytochemicals may have a therapeutic effect in reduced inflammation though skin penetration, some scientists suggested.

The results of these investigation were carried out by some respectable institutes, including the Albert-Ludwigs-University Freiburg.

You can view the article as the differentiation were published on some online literature, including public medical library.

Inflamamtion is a natural reaction of immune response to protect the damage or injure tissue against foreign invasion.

However, over production of pro inflammatory cytokines may induce normal cell deaths and forming of scars.

Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is process of repairing after damage of skin, tissues, organs, etc.


The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivative.

In inflammatory diseases, topical of Arinca preparation exerted a significantly anti inflammatory activity through skin penetration of sesquiterpene lactones (SLs) from the helenalin and 11alpha,13-dihydrohelenalin, the major bioactive compound found in the herb.

Sesquiterpene lactones (SLs) isolated from Arnica, according to a gas chromatography/mass spectrometry method in tested subjects, in investigation of penetration behaviour of one gel preparation and two ointment preparations demonstrated the comparable penetration through the stratum corneum, the uppermost part of the skin. 

These results suggested that the bioactive compound induced efficacy by injecting its effectiveness through the horny outer layer of the skin in inhibited the production of anti inflammatory cytokines without ameliorating the immune response to the site of infection.

Levels of sesquiterpene lactones (SLs) was slowly decrease, 4 hours after injection in compared to penetration rate of ointments kept constant over time. 

Dr. Wagner S, the lead author, after taking into account of other co and con factors said, "the totally penetrated amount of SLs only depends on the kind of the formulation and of the SLs-content in the formulation but not on the SLs composition or on the used extraction agent".

Further testing the anti inflammatory property of Sesquiterpene lactones (SLs) islated fron Arnica, researchers at the Albert-Ludwigs-Universität Freiburg conducted an investigation, using some alcoholic preparations of fresh Arnica flowers and an Arnica fresh plant gel.

The stripping method with adhesive tape and pig skin were used as a model to determine the quantity of SLs in the stripped layers of the stratum corneum (SC). 

According to the observation, application of isolated SLs permeated through the SC in a very small amount, in compared to permeation of SLs much higher when they were present in the tinctures.

Tested Arnica preparations of fresh Arnica flowers with two preparations showed the best penetration behaviour of all the tested substances.

These conclusion suggested that all preparations reconfirm the efficacy of Arnica in attenuated over expression of inflammation induced by immune  response and some preparations consisted a better anti inflammatory effect than others. 

Dr. Wagner S, the lead scientists once again said, "a sufficient amount of SLs might permeate the skin barrier by using Arnica preparations to exert anti-inflammatory effects and that the topical use of plant preparations may be advantageous compared to the isolated compounds".

Interestingly, in the analysis of SLs therapeutic relevance as single components for the local treatment of inflammation, Dr. Merfort I suggested that " SLs may be favourable in dual therapy or in the inhibition of leukaemia cell growth" and "native SLs serve as leads that have to be optimised in terms of their specificity, pharmacokinetics and absorption, distribution, metabolism and excretion (=ADME) properties".

Taken together, herbal Arnica and Its bioactive compound, particularly sesquiterpene lactones (SLs) may be used alone as a topical substance or combination with conventional medicine for treatment of all forms of  inflammatory diseases.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Skin penetration behaviour of sesquiterpene lactones from different Arnica preparations using a validated GC-MSD method by Wagner S1, Merfort I.(PubMed)
(2) Skin penetration studies of Arnica preparations and of their sesquiterpene lactones by Wagner S1, Suter A, Merfort I.(PubMed)
(3) Perspectives on sesquiterpene lactones in inflammation and cancer by Merfort I(PubMed)

^^^^How to Prevent and Treat Infectious Diseases Naturally and Effectively, MEDLINE Studies Suggestions

Kyle J. Norton 

Including green tea as a beverage in your diet may have a therapeutic and positive effect in reduced risk and treatment of bacterial and viral infectious diseases, some scientists suggested.

The results of the analysis were carried out by numbers of institutes, including the Yonsei University and punished on online medical literature.

Green tea, is a precious drink processed numbers of health benefit known to almost everyone in Asia and Western world.

According to Review provided by VeriMed Healthcare Network. intake of green tea 2 to 4 cups per day  by steep covered 5 to 10 minutes for leaf or flowers and 10 to 20 minutes for roots was  associated to support immunity while providing antibacterial and antiviral activity.

Also, green tea (Camellia sinensis) extract of 250 to 500 mg daily, enhanced immune function due to its antioxidant, anti-inflammatory, and immune effects.

Moreover, tannin, green tea derived polyphenols and other related compounds, in the study to investigate the anti-viral effects of tannins on 12 different viruses including both enveloped viruses (influenza virus H3N2, H5N3, herpes simplex virus-1, vesicular stomatitis virus, Sendai virus and Newcastle disease virus) and non-enveloped viruses (poliovirus, coxsachievirus, adenovirus, rotavirus, feline calicivirus and mouse norovirus) researchers suggested that application of tannin reduced some viral infectivity in compared to persimmon (Diospyros kaki) with more than 4-log scale against all of the viruses tested.

More importantly, the differentiation of epigallocatechin-3-gallate (EGCG) effect against viral infections also indicated that EGCG injection in solution type and powder types over extended periods at various temperature conditions exerts a strong effect in inhibited the tested human influenza A/H1N1 virus.

Green tea extract in the study also demonstrated potent viral inactivating activity for over a period of up to 2 months.

These results suggested that adding green tea supplement GTE may provide a greater than 4 log10 reduction of viral titers at a wide range of temperatures.

Dr. Lee YH, after taking intoaccount of other co and confouders said, "GTE-based antiviral agents could be formulated as a safe and environmentally friendly personal hygiene against viral infections".

The findings showed that green tea and green tea extract may be considered as function foods in reduced risk and treatment of infectious diseases caused by bacterial and viral invasion.

However, intake of green tea supplementations should be taken with extreme care as acute liver toxicity has been reported in numbers of cases.

Reprint of this article is welcome with author name and link to the article sources intact https://kylejnorton.blogspot.ca/

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Measle  Reviewed By: Steven D. Ehrlich, NMD, Solutions Acupuncture, a private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed Healthcare Network.
(2) Inactivation of Pathogenic Viruses by Plant-Derived Tannins: Strong Effects of Extracts from Persimmon (Diospyros kaki) on a Broad Range of Viruses
Kyoko Ueda, 1 Ryoko Kawabata, 1 Takashi Irie, 1 Yoshiaki Nakai, 2 Yukinobu Tohya, 3 and Takemasa Sakaguchi 1 (PMC)
(2) Evaluation of green tea extract as a safe personal hygiene against viral infections by Lee YH#1, Jang YH#1, Kim YS1, Kim J2,3, Seong BL1,4.(PubMed)

How to Treat Lower Back Pain Efficiently and Naturally, According to Studies of MEDLINE database's Suggestion

Kyle J. Norton


Green tea and its bioactive catechin epigallocatechin 3-gallate (EGCG) may have a therapeutic and positive effect in ameliorated symptoms and treatment of chronic back pain, some scientists suggested.

Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Back pain is a condition of Musculo-Skeletal disorders(MSDs) of the spine caused by various factors, including bone fractures, muscle or ligament injure, arthritis, herniated discs. aging,....


Application of biologically active polyphenol epigallocatechin 3-gallate (EGCG) demonstrated a significant effect in reduced back pain through facilitate anti inflammatory and anti-catabolic activity in patients with intervertebral disc (IVD) disease due to age-related changes in the adult disc in induction of back pain.

According to the study by the Institute for Biomechanics (D-HEST), ETH Zurich ingestion of green tea EGCG on back pain patients, human IVD cells isolated from patients undergoing surgery due to degenerative disc disease (n = 34) and cultured in 2D or 3D indicated that the phytochemical inhibited levels of inflammatory response activated by IL-1β, a cytokine protein produced by macrophages, with function in contributed to the inflammatory pain hypersensitivity in the site of infection observed by the reverse transcription polymerase chain reaction (qRT-PCR), western blotting, enzyme-linked immunosorbent assay (ELISA), immunofluorescence and transcription factor assay.

Further more, application also displayed a strong effect in reduced expression of
p38 mitogen-activated protein kinases in mediated inflammatory factors of IL-1β in responded to stress stimuli.

Also, according to the Institute for Biomechanics (D-HEST), in the investigation of the analgesic properties of EGCG, by the von Frey filament test in Sprague-Dawley rats (n = 60), green tea EGCG injection also significantly inhibited the expression of pro-inflammatory mediators as expressed in above and reduced matrix metalloproteinases which have been found to associate to pro-inflammatory cytokines, chemokines and other proteins to regulate varied aspects of inflammation and immunity.

Moreover, in the radiculopathic pain component, researchers also indicated that EGCG inhibited the inflammation in precipitated back pain through modulation of the activity of IRAK-1 in glucose metabolism and insulin sensitivity in skeletal muscle and p38, c-Jun N-terminal kinases (JNK) and nuclear factor NF-κB in responded to stress stimuli in mediated production of pain related pro inflammatory cytokines such as IL-1β.

Some researchers postulated that back pain may also induced by muscle degeneration and impairment nerve injury, leading to increased levels of reactive oxygen species in induced tissue apoptosis.

In crushing of the sciatic nerve induced back pain in tested animal, application of green tea EGCG improved motor function in the toe spread and foot positioning and gain in the percentage motor deficit.

More importantly, EGCG expressed a significant effect in recovery of sensory innervation in neuropathic pain-like syndrome and improvement of muscle tissues from injured limb with severe histopathological alterations at the end of week 3 post-surgery in treated animals.


According to the RT-PCR assay, EGCG treatment also normalizing the Bax/Bcl-2 ratio, abnormal ratio of the Bax/Bcl-2 ratio has been found to associate in induction of nerve cell apoptosis as well as inhibited levels of p53 with function in regulated the cell death cycle at days 3 and 7 post-surgery.

These results demonstrated a important effect of green tea EGCG in enhanced functional recovery, protected muscle fibers from cellular death, and improved morphological recovery in skeletal muscle after nerve injuries.


However, in the study of caffeine activity in the modulation of pain perception in chronic pain states of 131 patients with chronic low back pain (64 men and 67 women; mean age = 42.1 years; mean duration of pain = 6.1 years) referred to a multidisciplinary pain clinic over a 2-year period, researchers found that in compared to caffeine intake regardless concentration, cffeine is not related to the global experience of pain and disability in patients with chronic low back pain, although high caffeine use may be embedded in a context of other unhealthy life-style behaviors.

Taken together, green tea and its bioactive component epigallocatechin 3-gallate (EGCG) may be considered as functional food in reduced back pain caused by physical damage of the spine and injured nerve cells. Intake of green tea supplement should be taken exceptional care as some cases of liver acute toxicity have been reported in medical literature.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Epigallocatechin 3-gallate suppresses interleukin-1β-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats by Krupkova O1, Sekiguchi M, Klasen J, Hausmann O, Konno S, Ferguson SJ, Wuertz-Kozak K.(PubMed)
(2) (-)-Epigallocatechin-3-gallate (EGCG) attenuates functional deficits and morphological alterations by diminishing apoptotic gene overexpression in skeletal muscles after sciatic nerve crush injury by Renno WM1, Al-Maghrebi M, Al-Banaw A.(PubMed)
(3) Caffeine and chronic low back pain by Currie SR1, Wilson KG, Gauthier ST.(PubMed)

How to Prevent Onset of Alzheimer’s disease, US National Library of Medicine Studies Suggested

By Kyle J. Norton

Coffee intake may have a positive implication in reduced risk of early onset of Alzheimer’s disease, a respectable joint study suggested.

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Alzheimer’s disease is generalized and progressive neuro degenerative disease due to aging.

In a rat model for Alzheimer’s disease (AD) induced by phosphoprotein phosphatase 2A (PP2A), eicosanoyl-5-hydroxytryptamide (EHT), researchers showed that components found in coffee exhibited a protective effect against AD, through inhibited expression of the I2(PP2A), or SET protein involved multiple cellular processes in the brains.

More importantly, oral administration of the supplement for 12 months showed a strong attenuated all the defects of cognitive impairment, including tau hyperphosphorylation, and elevated levels of cytoplasmic amyloid-β protein caused by phosphoprotein phosphatase 2A (PP2A) injection.


Dr. Basurto-Islas G, the lead author in the joint study said, ” possibility that EHT may make a substantial contribution to the apparent neuroprotective benefits associated with coffee consumption as evidenced by numerous epidemiologic studies indicating that coffee drinkers have substantially lowered risk of developing AD”.

Further more, Dr. Wierzejska R in the evaluated effects of caffeine coffee in dietary factors which might prolong mental agility, said, ” moderate coffee consumption in fact has a lower the risk for common neurodegenerative conditions, i.e. Alzheimer’s and Parkinson’s diseases” and “Possibly, in the future experts will recommend drinking coffee not only to satisfy individual taste preferences but also to decrease age-related mental deterioration.”.

Others, in the concerns of the high consumption of coffee in effect of individual’s health through evaluating database of online medical literature, researchers found that coffee-drinking habits, and/or the quantity of coffee consumption, have a significantly reduced risk of dementia/AD, and other chronic diseases, but the the underlying mechanisms are not fully understood, when comparing coffee drinkers with non-drinker.

Taking together, regular drinking of caffeine coffee in a moderated amount daily may have a positive effect in attenuated risk and progression of Alzheimer’s disease and caffeine may be considered as a novel therapy for treatment of Alzheimer’s disease.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Therapeutic benefits of a component of coffee in a rat model of Alzheimer’s disease by Basurto-Islas G1, Blanchard J1, Tung YC1, Fernandez JR2, Voronkov M2, Stock M2, Zhang S3, Stock JB4, Iqbal K5.(PubMed)
(2) Can coffee consumption lower the risk of Alzheimer’s disease and Parkinson’s disease? A literature review by Wierzejska R1.(PubMed)
(3) Possible health effects of caffeinated coffee consumption on Alzheimer’s disease and cardiovascular disease by You DC1, Kim YS, Ha AW, Lee YN, Kim SM, Kim CH, Lee SH, Choi D, Lee JM.(PubMed)