Herbal Therapy: Herbal Anise in Reduced Risk of Infectious Diseases Through its Antiviral Activities

Kyle J. Norton

Essential oil Anise may have a potential and substantial effect in reduced risk and progression and treatment of viral infectious diseases, some scientists suggested.

Anise is a flowering plant ofthe species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to to Egypt and the Mediterranean region, used in traditional herbal medicine as fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, ....


Chemical comstituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

In the investigation of the effects of several essential oils, including Anise in against expression of herpes simplex virus type 2 (HSV-2) in vitro on RC-37 cells, using a plaque reduction assay, researchers found that application of essential oil of concentrations (IC50) at doses of 0.016%, 0.0075%, 0.007%, 0.004%, 0.003% and 0.0015% demonstrated significant effects linearly in ameliorately persistent infection spreading of sexually transmitted disease of the virus.

At maximum dose, essential oil of Ansie without inducing cytotoxicity to healthy cells, exerted an inhibitory effect against different stages during the viral infectious cycle and plaque formation by more than 90%.

Interestingly, all essential oils displayed no inhibitory effect cells prior to infection with HSV-2 or after the adsorption period.

These results suggested that injection of Ansis essential oil can only affect HSV-2 after penetrating into  the viral envelope.

In compared to the inhibitory effects of all essential oil, Anise exhibited a less selectivity activity in compared to essential oil isolated from chamomile.

Further demonstration of Anise anti viral activity, using 3 antiviral and immunostimulating substances (LC1, LC2 and LC3) isolated from a hot water extract of seeds of Pimpinella anisum by combination of anion-exchange, gel filtration and hydrophobic interaction column chromatographies researchers at the University of Toyama suggested that the lignin and carbohydrate molecules(CLs) bonded physically or chemically with each other of LC1, LC2 and LC3 exerted a significantly antiviral activities in reduced expression of herpes simplex virus types 1 and 2 (HSV-1 and -2), human cytomegalovirus (HCMV) and measles virus.

Moreover, application of all LCs substances inhibited the virus induced-adsorption to the host cell surface by direct inactivating the viruses penetration through enhanced nitric oxide (NO) production by inducing iNOS mRNA and protein expression in RAW 264.7 murine macrophage cells in response to viral attacks.

These result of rival inhibitory effect of Anise LCs substances not only prevented virus in alternated the healthy cells DNA in initiated infectious cell proliferation but also inhibited production of interleukin 1 beta (IL-1β) and interleukin 10 caused by over reaction of immune response in elevated expression of pro inflammatory cytokines in induction of healthy cell damage and cell apoptosis.

The above differentiation were supported by the study in the evaluated the effect of limonene, the major bioactive compound found in Fennel and Ansie in inhibited risk and progression and treatment  of dengue, a potentially fatal mosquito-borne infection of 50 million cases per year with 2.5 billion people who are vulnerable to the disease.

According to the results, application of essential oil using WHO procedures, displayed a substantial effect against third instar larvae of Ae. aegypti for 24 h.

More specifically, the result of inhibition of over 99% of tested virus were attributed to major constituent (-)-limonene at lethal concentrations LC50, C90 and LC99.

Taken together, Anise and its major bioactive monoterpenes may be considered as a possessed potency as functional food ingredients against infectious diseases cause by viral invasion.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN

Arthritis Is Curable

You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Antiviral and immunostimulating effects of lignin-carbohydrate-protein complexes from Pimpinella anisum by Lee JB1, Yamagishi C, Hayashi K, Hayashi T.(PubMed)
(2) Inhibitory effect of essential oils against herpes simplex virus type 2. by Koch C1, Reichling J, Schneele J, Schnitzler P.(PubMed)
(3) Larvicidal activity against Aedes aegypti of Foeniculum vulgare essential oils from Portugal and Cape Verde by Rocha DK, Matosc O, Novoa MT, Figueiredo AC, Delgado M, Moiteiro C.(PubMed)

Alternative Therapy: Yoga in Reduced Psychological Symptoms and Improved Quality of Life in Schizophrenia

Kyle J. Norton 

Yoga lessons may be used as conjunction of other standard treatment in reduced symptoms and hospitalization and improved quality of life, in patients with schizophrenia, the University of Duisburg-Essen suggested.

Schizophrenia is a mental disorder induced inconsistent or contradictory elements such as breakdown of certain relation in thought, emotion, and behavior, leading to faulty perception, inappropriate actions and feelings,....

Yoga, the ancient technique practice for harmonized external and internal body well beings, through breath control, meditation, bodily movement and gesture..... has been best known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In the review literature published online MEDLINE/Pubmed, Scopus, the Cochrane Library, PsycInfo, and IndMED through August 2012 in comparing yoga to usual care or non-pharmacological interventions related to symptoms or quality of life in patients with schizophrenia, 5 studies met the criteria indicated that
* There were no evidence was found in compared to usual care on positive symptoms and improved social function in short term valuation
* Yoga group expressed a moderate evidence in short-term effects on quality of life compared to usual care 3. Only one study showed insignificantly adverse events.

The findings suggested that yoga intervention may have a moderated effect in reduced symptoms and other aspects of patients with schizophrenia without mentioning the effects in long term yoga participation.

Truly, yoga slow breathing and meditation induced calmness to the central nervous system in reduced production of stress hormone such as adrenaline and cortisol, and the precursor hormone DHEA in exaggerated stress responses in initiated mental health expression of anxiety and depression.

Fluctuation of hormone imbalance can cause mixed of symptoms.

Further more, yoga application also reconnected and re-balanced the mind and body in induced a state of relaxation to the central nervous system thus ameliorating neurons in transmitting of faulty chemistry in facilitated wrongly emotional responses.

Moreover, by reconnecting the mind and the emotional response, yoga improves awareness by bringing back the presence and dealing them with the positive ways through increasing awareness of the surrounding, such as paying attention of the reality and moving away from the delusional past, thus increasing acceptance and adaptability to the new change for better recovery.

Most importantly, yoga mindfulness also promoted the sense of security of the mental illness patients, through patient's sense of well beings and satisfaction with his/her life circumstances in  environment that is least restrictive, safest, homely as well as a person's health status.

Easier said than done, yoga intervention may also have a potential in restored the balance and mental connection into tackling psychosomatic problems and psychiatric disorders. However, according to some researchers, it is often difficult to motivate a mental illness person to feel comfortable in doing yoga practices, but with the patience of the caregivers in gently persuasion, as time progressed, most patients might slowly enjoy the exercise and eager to carry on.

The above differentiation were supported by the literature review to assess the effectiveness of yoga as a complementary treatment on general psychopathology, positive and negative symptoms and health-related quality of life (HRQL) for people with schizophrenia by the University Psychiatric Centre Katholieke Universiteit Leuven.

According to the results of study, although the information were limited, yoga group demonstrated an strong effect in reduced general psychopathology and positive and negative symptoms and yoga lessons improved the health-related quality of life in those antipsychotic-stabilised patients with schizophrenia and also promoted the sense of security of the mental illness patients,

And, a randomized study of changes in state anxiety, psychological stress and subjective well-being after single sessions of yoga and aerobicexercise compared with a control condition by the Catholic University Leuven.

After taking into account of other confounders, researchers found that state of anxiety significantly decreased after single sessions of yoga and aerobic exercise in individuals with schizophrenia in compared to control.

Patients participated in the single class of yoga or aerobic exercise also  showed a decreased psychological stress and increased subjective well-beings without inducing statistically significant difference in both yoga and aerobic exercise groups.

With all the information collected, there are no doubt that yoga lessons in both short and longterm may have a profound and strong effect in reduced psychological symptoms and improved health related quality of life in patients with schizophrenia:

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Yoga for schizophrenia: a systematic review and meta-analysis by Cramer H1, Lauche R, Klose P, Langhorst J, Dobos G.(PubMed)
(2) Yoga in schizophrenia: a systematic review of randomised controlled trials by Vancampfort D1, Vansteelandt K, Scheewe T, Probst M, Knapen J, De Herdt A, De Hert M.(PubMed)
(3) State anxiety, psychological stress and positive well-being responses to yoga and aerobic exercise in people with schizophrenia: a pilot study by Vancampfort D1, De Hert M, Knapen J, Wampers M, Demunter H, Deckx S, Maurissen K, Probst M.(PubMed)

Food Therapy; Fennel Seeds, A Potent Galactogenisis in Increased Milk Secretion in Lactation Period

Kyle J. Norton

Fennel may have potential and therapeutic effect in improved milk secretion, some scientsits suggested.

Galactogenisis is a function in promoted lactation in milk insufficient feeding baby's women.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.


In the finding the natural sources for answer of the question of produced enough milk in women who face challenges in their efforts to breast-feed their infants, researchers at the CANADIAN JOURNAL OF MIDWIFERY RESEARCH AND PRACTICE conducted a study of  a total of 23 women at one to four months postpartum to share their experiences with childbirth and postpartum self-care, suggested that out of 23 women interviewed, 4 women reported insufficient milk supply and 11 women showed an improvement of lactation by using galactagogue substances, including herbal medicine fennel.

According to the survey returned from these participants, four women used fennel seed or oil, and all considered herbal product were effective as galactagogue. One learned about it from a friend, two from their midwives, and one from her mother who used it herself while breast-feeding.

These results suggested that herbal medicine including fennel may process a significant benefit in increased milk production but Dr. Rachel Emma Westfall, PhD suggested that further investigation are necessary to validated this viability.

Although, the mechanism in enhanced lactation effects of fennel seeds acting as galactagogues are little known, some scientists postulated that the result of fennel in increased milk secretion was attributed to the phytochemical anethole in expression of estrogenic property.

Anethole, the main constituent of the essential oils of fennel and anise, has been considered as an active estrogenic agent by actual pharmacologically active investigation.

Truly, according to the Cochrane Pregnancy and Childbirth Group, in the evaluation of the fennel effect in increased milk production breast feeding mothers suggested that anethole, the major bioactive compound isolated from fennel is considered weakly estrogenic agent and may increase breast milk production or assist with the ‘let-down’ reflex, through enhanced function of hormone oxytocin.

These results suggested that fennel as a galactagogues may improve milk production by working, either directly or indirectly, on the hormonal pathways that control lactation.

In other words, application of fennel restored the function of hormone pralactin in induction of milk formation and hormone oxytocin produced by the pituitary gland with function to contract special muscle cells around the alveoli in the breast to ensure the expulsion of milk.

To ensure these process continued without interuption, application of fennel seed also rebalance the hormone secretion by preventing over production of estrogen and progesterone in reduced expression of hormone prolactin in inhibited milk production. according to the results in animal models.

By blocking serum of estrogen and progesterone in blood circulation, fennel seed ensured that the pituitary gland continuously releases of prolactin in stimulated mammary gland cells in secretion of milk.

Some researchers suggested, the function of fennel in facilitated milk formation and secretion may also be as a result of increasing numbers of milk-secreting cells during the lactation state caused by sucking of the young by enhancing the growth of mammary alveolar growth, prolactin, or both. 

Today, even with extensive researchers, there is little known about the mechanisms of fennel seeds in enhanced production of milk during lactation period. Some researchers concerned that over doses of fennel seeds may cause potential adverse effects since dosages for galactagogues are mostly unquestioned and untested.

Taken together, fennel seeds may have a potential effect as galactogenic herbal medicine in increased milk formation and production. However, further study with a large sample size conducted by multi centers are necessary to re-confirm its viability scientifically.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN

Arthritis Is Curable

You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Galactagogue Herbs: A Qualitative Study and Review by Rachel Emma Westfall, PhD(Journal of Midwifary) file:///C:/Users/hhh/Downloads/v2n2_westfall_galactagogue-herbs.pdf
(2) Oral galactagogues for increasing breast-milk production in mothers of non-hospitalised term infants by Siew Cheng Foong, May Loong Tan, Lisa A Marasco, Jacqueline J Ho, Wai Cheng Foong(Cochrance Library)

Herbal Therapy: Green Tea, the Camellia Sinensis Leaves In Spelled Death of Tuberculosis in Third World Countries

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced risk and progression and treatment of tuberculosis (TB), some scientists suggested.

Tuberculosis (TB) is a disease caused by bacteria called Mycobacterium tuberculosis. Commonly, the bacteria attacked the lung tissue but also can cause major damage to other parts of the body.

Green tea, is a precious drink processed numbers of health benefit and known to almost everyone in Asia and Western world.

According to statistic, 25% of the world's population is infected with TB. In 2016, 10.4 million people around the world became sick with the disease induced 1.7 million deaths.

In the investigation of the effect of reactive oxygen species (ROS) in risk of tuberculosis of a total of 200 newly diagnosed cases of AFB positive pulmonary tuberculosis, with 100 patients randomly received catechin (500 microg) with antitubercular treatment (ATT) (cases) and the other 100 received starch (500 microg) with ATT (control), researchers at the Chhatrapati Shahuji Maharaj Medical University found that CTN treatment group exerted a significant activity in reduced levels of free radical expression through reduced oxidative stress in compared to control, observed by analysis of the blood samples.

Further analysis suggested that green tea CTN treatment group restored the balanced of antioxidant and free radicals ratio by stimulated production of levels of enzymatic antioxidant (catalase, superoxide dismutase, glutathione peroxidase) and non enzymatic antioxidant (total thiol, reduced glutathione) levels and significant decreased expression of free radicals (lipid peroxidation, nitric oxide).
These results re-constituted the efficacy of crude catechin extract as adjuvant therapy in management of oxidative stress seen in pulmonary tuberculosis patients.

Moreover, in monitor the extent of oxidative stress in mice infected with M tuberculosis and the role of crude green tea extract in repairing the oxidative damage by divided them into three groups of  normal, infected-untreated and infected-treated with 9 members in each group, scientists indicated that infectous untreated group exerted a significant enhancement of antioxidants produced by the natural defense of the body such as  erythrocytic catalase and glutathione peroxidase activities along with elevated levels of free radical defenders such as erythrocytic total thiols but decreased levels of antioxidant activity of superoxide dismutase and  glutathione in erythrocytes and increased levels of free radicals plasma lipid peroxidation as compared to normal animals as expected.

These results suggested that non CTN tested mice exerted the protection against application of infectious agent selectively either through expression of natural antioxidant produced by the body or  antioxidants produced by the body were inhibited by the injection substance.

Importantly, ingestion of green tea CTN upon 7 days in infectious mice group completely restored the normal values of antioxidants and ROS ratio observed by the oxidative stress parameters.

In other words, green tea treatment group showed an increased catalase, glutathione peroxidase, total thiol and decreased extent of lipid peroxidation with concomitant increase in the levels of SOD and glutathione in infected animals, thus reducing development of tuberculosis risk.

The above differentiation were supported by the Department of Experimental Medicine and Biotechnology, Chandigarh in the study to determine whether or not polyphenols derived from green tea could down-regulate TACO gene transcription in reduced uptake/survival of M. tuberculosis within macrophages.

According to the The reverse-transcriptase polymerase chain reaction and reporter assay technology, application of major component of green tea polyphenols, epigallocatechin-3-gallate EGCG reduced expression of TACO gene transcription within human macrophages through its ability in inhibited Sp1 transcription factor in blocking the mycobacterial entry/survival within human macrophages in initiation of infectious cellular processes, including cell differentiation, cell growth, immune responses.

Dr. Anand PK, the lead authors, said, "The down-regulation of TACO gene expression by epigallocatechin-3-gallate was accompanied by inhibition of mycobacterium survival within macrophages as assessed through flow cytometry and colony counts" and "epigallocatechin-3-gallate may be of importance in the prevention of tuberculosisinfection".

Taken together, green tea and its bioactive polyphenols in attenuated risk and treatment of tuberculosis caused by Mycobacterium tuberculosis may contribute significantly to the prevention and treatment of tuberculosis in third world countries where the conventional medicine are scarce or un-affordable to general population.

Reprint of this article is welcome with author name and link to the article sources intact https://kylejnorton.blogspot.ca/2018/03/607-herbal-therapy-green-tea-in-spelled.html

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Effect of green tea extract (catechins) in reducing oxidative stress seen in patients of pulmonary tuberculosis on DOTS Cat I regimen by Agarwal A1, Prasad R, Jain A.(PubMed)
(2) Protective effect of green tea extract against the erythrocytic oxidative stress injury during mycobacterium tuberculosis infection in mice by Guleria RS1, Jain A, Tiwari V, Misra MK.(PubMed)
(3) Green tea polyphenol inhibits Mycobacterium tuberculosis survival within human macrophages by Anand PK1, Kaul D, Sharma M.(PubMed)

Herbal Therapy: The Best of Perennially Herbal Fennel In Ameliorated Risk, Progression and Treatment of Prostate cancer

Kyle J. Norton

Fennel may have potential and positive effect in reduced risk, progression and treatment of prostate cancer, some scientist suggested.

Prostate caner is a chronic condition characterized by abnormal growth of prostate tissue. At he later stage, the cancerous cells may travel a distance away to infect other healthy cells and tissues.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...


Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc


In the study to investigate the effect of 5 herbal medicine in different quantity in some different formulas represented by FB, FM, PP, HF and FBL101 in risk of prostate cancer, including licorice, black cohosh, Dong Quai, false unicorn and vitex berry root extracts, fennel seed extract, researchers at the National Institute of Health found that FB, FM, PP, HF and FBL101 inhibited PC3 tumor growth by 53%, 75%, 80%, 81% and 87%, respectively.

In an androgen-independent human prostate cancer cell line CWR22R, all 5 formulas also inhibited the caner cell proliferation without alternating levels of testosterone.

However, administration of formula PP and FBL101 showed a significantly reduced VEGF levels with function in stimulated formation of new blood vessels in initiated proliferation in PC3 and CWR22R tumors.

Further more, intratumoral microvessel density measurement in expression of tumor growth with aggressive tumor behavior, was decreased in PC3 tumors treated with all five supplements but only in CWR22R tumors treated with HF.

Dr. Ng SS, after taking into account of other cofounders said, "herbal supplements containing the aforementioned extracts inhibit the growth of prostate tumor xenografts, possibly in part by antiangiogenic mechanisms".

These results demonstrated that fennel extract and other herbal components may be considered as preventive and therapeutic agents for treatment of prostate cancer without indicating the efficacy of individual herb.

The above differentiation were supported by the study of the Alexandria University in evaluation of anethole, a major constituent of Foeniculum vulgare (fennel) essential oil, a widely used folk medicine for treatment of prostate cancer.

According to the experiment, application of the bioactive compound anethole exerted a strong activity against proliferation, clonal growth and migration of PC-3 cells, through generation of ROS in induction of cytotoxicity through damage the DNA of the cancer cells.

Additional analysis of the efficacy, the application also stimulated the penetration of essential oil anethole in permeabilization of the mitochondrial and lysosomal membranes of PC3 cancer cell in induction of cancer cells death, executed by caspase-3 and -9 pathways and PARP cleavage in induction of apoptosis.

Interestingly, injection of anethole isolated from fennel essential oil also induced elevation of Bax/Bcl-2 protein ratio, in initiated the onset of prostate cancer cell death through cell cycle arrest.

Further observation of anethole action, researchers found that anethole inhibited prostate cancer cells through cell cycle arrest in G2/M phase ameliorated by levels of cyclins D1, CDK-4 and c-Myc proteins in promoted cancer cell cycle progression and enhanced production of levels p21 and p27 in exhibited tumor suppressible activity.

Finally, anethole also suppressed NF-κB protein in activated production of TNF-α in induction of anti-apoptosis in prostate cancer cells.

Taken together, the finding evidences strongly suggested that long term intake of fennel and its bioactive anethole may have substantial implication in prevention and treatment of prostate cancer. But intake of fennel supplement should be taken with care to prevent acute liver toxicity.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN

Arthritis Is Curable

You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Anethole Inhibits The Proliferation Of Human Prostate Cancer Cells Via Induction Of Cell Cycle Arrest And Apoptosis by Elkady A(PubMed).
(2) Antitumor activity of herbal supplements in human prostate cancer xenografts implanted in immunodeficient mice by Ng SS1, Figg WD.(PubMed)

The Magic of Camellia Sinensis Leaves: Green Tea in Expression of Anti Influenza Activity

Kyle J. Norton 

Green tea, the Camellia sinensis leaves may have a therapeutic and positive effect in reduced infectious risk by influenza, some scientists suggested.

Influenza, is also known s "the flu", is an infectious disease caused by an influenza virus
Green tea, is a precious drink processed numbers of health benefit and known to almost everyone in Asia and Western world.

In the investigated the green tea effect in reduced risk of influenza viral overspreading in general population, researchers at the Yonsei University conducted a study to evaluate catechin derivatives with different alkyl chain length and aromatic ring substitutions at the 3-hydroxyl group synthesized from epigallocatechin (EGC) and (+)-catechin (C) activity against influenza virus.

According to the experiment, application of catechin derivatives, carrying moderate chain length (7-9 carbons) exerted a pronounced effect in inhibited over expression of the virus in compared to those with aromatic rings.

Interestingly, injection of the 5'-hydroxyl group did not significantly contribute to antiviral activity against trihydroxy benzyl moiety.

However, administration of both derivatives demonstrated an inhibitory effect for all six influenza subtypes tested including three major types of currently circulating human influenza viruses (A/H1N1, A/H3N2 and B type), H2N2 and H9N2 avian influenza virus, through strongly inhibited adsorption of the viruses on red blood cell (RBC).

In vivo, the drivatives also expressed an impressive activity in restricted the growth of avian influenza virus with minimum inhibition concentration (MIC) of 5-10 microM far exceeding the dose of conventional medicine oseltamivir or M2 proton channel inhibitor amantadine with the same purposes.

Further analysis suggested that the derivatives isolated from actechin inhibited effect were attributed to the mediation and interaction with hemagglutinin (HA)/viral membrane at the initial stage of infection.

Dr. Song JM, the lead author, after taking account of all assessment said, "The broad spectrum activity against various subtypes of influenza viruses may complement the limitations of current antivirals and contribute for managing potentially emerging influenza pandemic".

Importantly, in the comparison of the theaflavins fraction (TF80%, with a purity of 80%) and three theaflavin (TF) derivatives potent inhibitory effects against influenza virus in vitro, scientists at the Chinese Academy of Medical Sciences & Peking Union Medical College indicated that application displayed a significant inhibitory effects on the HA of three different subtypes of influenza virus strains [A/PR/8/34(H1N1), A/Sydney/5/97(H3N2) and B/Jiangsu/10/2003] with 50% inhibitory concentration (IC(50)) values ranging from 9.27 to 36.55 μg/mL, probably though expression and interaction on HA as above differentiation.

Additionally, TF derivatives inhibited the over expression of viral particle infectivity consistently and corelatively with the inhibitory effect on HA.

According to the qPCR and  nuclear localization of the influenza virus vRNP assays, all applications exerted anti infectivity by interrupting the viral  replication and also decreased the production of inflammatory cytokine IL-6 in induction of serious tissue injury and apoptosis.

The above evaluation were supported by the Yonsei University study of the polyphenolic compound catechins ((-)-epigallocatechin gallate (EGCG), (-)-epicatechin gallate (ECG) and (-)-epigallocatechin (EGC)) from green tea in inhibited influenza virus replication in cell culture and for potentially direct virucidal effect.

According to the results, among all compound selected in the assessment, EGCG and ECG were found to be potent inhibitors of influenza virus replication in MDCK( in a suitable transfection host  for influenza research) cell culture, including A/H1N1, A/H3N2 and B virus, observed in all influenza virus subtypes tested. with 50% effective inhibition concentration (EC50) of EGCG, ECG, and EGC for influenza A virus at doses of 22-28, 22-40 and 309-318 microM.

The effective compounds EGCG and ECG also displayed an exhibited hemagglutination inhibition activity, similar to those in above studies.

Moreover, in compared to the EGCG and ECG anti influenza virus efficacy, researchers surprisingly found that at high concentration, EGCG + ECG also suppressed viral RNA synthesis in MDCK cells whereas EGC failed to show similar effect and EGCG + ECG inhibited the neuraminidase activity more effectively than the ECG.

These results reaffirmed the expression of green tea biocative polyphenols antiviral effect of catechins on influenza virus is mediated not only by specific interaction with HA, but  also alter the physical properties of viral membrane, Dr. Song JM, the lead author of the study suggested.

Taken together, green tea with abundant phytochemical polyphenols may be considered as a functional food for reduced risk, progression and treatment of infleunza infection.

Reprint of this article is welcome with author name and link to the article sources intact https://kylejnorton.blogspot.ca/2018/03/the-magic-of-camellia-sinensis-leaves.html

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Biological evaluation of anti-influenza viral activity of semi-synthetic catechin derivatives by Song JM1, Park KD, Lee KH, Byun YH, Park JH, Kim SH, Kim JH, Seong BL.(PubMed)
(2) In vitro anti-influenza virus and anti-inflammatory activities of theaflavin derivatives by Zu M1, Yang F, Zhou W, Liu A, Du G, Zheng L.(PubMed)
(3) Antiviral effect of catechins in green tea on influenza virus by Song JM1, Lee KH, Seong BL.(PubMed)

Herbal Therapy: Green Tea and Its Bioactive Epigallocatechin gallate (EGCG) in Ameliorated Risk, Progression and Treatment of Amyotrophic Lateral Fclerosis (Lou Gehrig's disease)

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced risk, progression and treatment of amyotrophic lateral sclerosis (ALS), some scientists suggested.

Green tea is a precious drink processed numbers of health benefit and known to almost everyone in Asia and Western world.

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a specific disease involved the death of neurons in controlling voluntary muscles.

According to the research published by the Hanyang University, administration of green tea Epigallocatechin gallate (EGCG) exerted a neuroprotective effect in reduced oxidative stress in orchestrated death of neurons.

In the evaluation of green tea EGCG in risk of amyotrophic lateral sclerosis (ALS) in human G93A(with function in responsible for destroying free superoxide radicals in the body) mutated Cu/Zn-superoxide dismutase (SOD1) gene in mice model, scientists found that

application of green tea EGCG at doses of 1.5, 2.9, and 5.8 microg/g body weight, dissolved in 0.5 ml of 0.9% sterile NaCl intraorally every day after 60 days of age demonstrate significant effects in prolonged the symptom onset  and life span of ALS mice through preserved more survival and attenuated death signals.

The result of increased life span of mutated gene mice was attributed to increased antioxidant activity of green tea in inhibited the levels of ROS in reduced cytotoxicity in initiated death of neurons in controlling voluntary muscles.

Further analysis of the effect of green tea in mutated SOD1-G93A in transgenic mice and wild-type mice randomly divided into EGCG-treated groups (10 mg/kg, p.o) and vehicle-treated control groups to assess the motor function, starting at the age of 70 days researchers found that injection of green tea treatment mice display a strong effect in delayed the onset of disease, and extended life span, similar to those in the Hanyang study.

Additional differentiation also indicated that green tea treatment group stimulated the production of numbers of new motor neurons in compared to control mice,

Interestingly, the application also decreased the over expression of microglial activation in initiated the inflammatory response due to neuronal damage and removed the damaged cells caused by phagocytosis production.

Prolonged and over expression of inflammatory cytokines may increase risk of neuron damage and in some cases death of the nerve cells.

Researchers in depth analysis showed that green tea reduced immunohistochemical reaction of NF-kappaB in response to the neuron damage (by antigens) through stimulated production of pro inflammatory factors (as antibody) and cleaved caspase-3 in induction of neuron apoptosis.

Moreover, application of green EGCG also expressed a similar result as in other studies in decreased protein level of iNOS and NF-kappaB in the spinal cords in orchestrated free radical NO levels and  inflammatory cytokines in neuron cell death in the spinal cord involving the onset of ALS.

Dr. Xu Z, the lead author after taking into account of other co founders said, "this study provides further evidences that EGCG has multifunctional therapeutic effects in the mouse model of ALS".

These result were supported by the study of the green tea effect in risk of Lou Gehrig's disease through reviewing the food selection of 44-item food frequency questionnaire of 1 million men and women enrolled and conducted in 1989 through 2002 for ALS mortality.

According to results of the study, researchers at the Harvard School of Public Health suggested that green tea injection is associated to reduced mortality rate of patients.

The information findings suggested that green tea and its bioactive polyphenol Epigallocatechin gallate (EGCG) may be considered as a function food for reduced risk and used combination with standard medicine in delayed progression and treatment of Amyotrophic lateral sclerosis (ALS).

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Diet and amyotrophic lateral sclerosis by Morozova N1, Weisskopf MG, McCullough ML, Munger KL, Calle EE, Thun MJ, Ascherio A.(PubMed)
(2) Neuroprotective effects of (-)-epigallocatechin-3-gallate in a transgenic mouse model of amyotrophic lateral sclerosis by Xu Z1, Chen S, Li X, Luo G, Li L, Le W.(PubMed)
(3) The effect of epigallocatechin gallate on suppressing disease progression of ALS model mice by Koh SH1, Lee SM, Kim HY, Lee KY, Lee YJ, Kim HT, Kim J, Kim MH, Hwang MS, Song C, Yang KW, Lee KW, Kim SH, Kim OH.(PubMed)