Friday, 9 February 2018

Herbal Therapy: Herbal Anise In Reduced Risk, Progression and Treatment of Colon Cancer

Kyle J. Norton


Anise may have a potential and substantial effect in reduced risk and progression and treatment of colon cancer, some scientists suggested.

Anise is a flowering plant ofthe species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to to Egypt and the Mediterranean region, used in traditional herbal medicine as fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, ....

Chemical comstituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

In the study of a green synthesis route to produce AgNPs by using an aqueous extract of Pimpinella anisum seeds (3 mM) on human neonatal skin stromal cells (hSSCs) and colon cancer cells (HT115) researchers found that under infleunces of Anise extract, AgNPs exhibited a strong cytotoxicity effect against hSSC cells and HT115 cells through inhibited the cell proliferation and induced apoptosis, in dose dependent manner, according to proliferation tests and cell viability assays.

Further differentiation also suggested that green-synthesized AgNPs exerted a significant effect against five infectious bacteria: Staphylococcus pyogenes (29213), Acinetobacter baumannii (4436), Klebsiella pneumoniae (G455), Salmonella typhi, and Pseudomonas aeruginosa which have been associated to increase risk of colon cancer.

After taking into account of other con founders, Dr. Alsalhi MS, the lead author suggested that
P. anisum-synthesized AgNPs as novel and cheap bioreducing agents for eco-friendly nanosynthetical routes in treatment of colon cancer.

Moreover, the examine 3 commercially grown native herbs unique to Australia, Tasmannia pepper leaf (Tasmannia lanceolata R. Br., Winteracea; TPL), anise myrtle (Syzygium anisatum Vickery, Craven & Biffen, Myrtaceae; AM) and lemon myrtle (Backhousia citriodora F. Muell, Myrtaceae; LM) as well as a reference sample bay leaf (Laurus nobilis L., Lauraceae; BL), cytoprotective properties in colon adenocarcinoma (HT-29) cells, indicated that Anise demonstrated a potential effect in inhibited colon  cancer cell line HT-29 with IC(50) through
increased antioxidant activity in reduced expression reactive oxygen species in initiation of cancer cell proliferation.

Additionally, Application of Anise promoted colon cancer cells death by activating caspase-3 enzyme in enhanced the killer T cells activity to initiate cancer cells apoptosis by killer T cells.

According to the Cytokinesis-block micronucleus cytome assay, application of Anise extract inhibited colon adenocarcinoma (HT-29) cells at concentration of 0.5 and 1.0mg/ml. without causing harm to the neighbor healthy cells.

The above analysis were supported by the study in evaluated the effect of the volatile preparations of essential oils of the Greek plants Ocimum basilicum (sweet basil), Mentha spicata (spearmint), Pimpinella anisum (anise) and Fortunella margarita (kumquat) on model of human colon carcinoma.

Application of the herbal preparation expressed a significant activity in precipitated cytotoxicty effect in some infectious microorganisms associated to facilitation of the early state of colon cancer.

According to the DPPH and ABTS assay, application of all herbal essential oils also increased expression of antioxidant in decreased free radical expression in elevated cancer cell in cycle division.

Dr. Fitsiou E, the lead author said, "All essential oil preparations exhibited a variable degree of antiproliferative activity, depending on the cancer model used, with the most potent one being sweet basil against an in vitro model of human colon carcinoma".

The information findings suggested that Anise may be considered as a functional herb for reduced risk, progression and treatment of colon cancer. However, intake of Anise extract should be taken with care as some supplement have been found to induced acute liver toxicity.


For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN

Arthritis Is Curable

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Green synthesis of silver nanoparticles using Pimpinella anisum seeds: antimicrobial activity and cytotoxicity on human neonatal skin stromal cells and colon cancer cells by Alsalhi MS1, Devanesan S1, Alfuraydi AA2, Vishnubalaji R3, Munusamy MA2, Murugan K4, Nicoletti M5, Benelli G6.(PubMed)
(2) Cytoprotective and pro-apoptotic activities of native Australian herbs polyphenolic-rich extracts by Sakulnarmrat K1, Fenech M, Thomas P, Konczak I.(PubMed)
(3) Phytochemical Profile and Evaluation of the Biological Activities of Essential Oils Derived from the Greek Aromatic Plant Species Ocimum basilicum, Mentha spicata, Pimpinella anisum and Fortunella margarita by Fitsiou E1, Mitropoulou G2, Spyridopoulou K3, Tiptiri-Kourpeti A4, Vamvakias M5, Bardouki H6, Panayiotidis MΙ7, Galanis A8, Kourkoutas Y9, Chlichlia K10, Pappa A11.(PubMed)

Herbal Therapy: Herbal Anise in Ameliorated Risk, Progression and Treatment of Chronic Inflammatory Systemic Diseases

Kyle J. Norton


Anise may have a potential and substantial effect in reduced inflammatory expression in induction of symptoms of swelling, redness pain, hot,..., some scientists suggested.

Anise is a flowering plant ofthe species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to to Egypt and the Mediterranean region, used in traditional herbal medicine as fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, ....

Chemical comstituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

Inflammation is the natural reaction of immune system in protect our body against microorganism in the acute phase of infection.

Chronic inflammatory diseases are medical conditions including rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, inflammatory bowel diseases, and others typically stimulate a systemic response of the entire body.
According to the investigation of the essential oil of air-dried Illicium anisatum (Illiciaceae), obtained by hydrodistillation effect in LPS in induction of inflammation in RAW 264.7 cells, researchers at the Jeju Hi-Tech Industry Development Institute found that application of the essential oil demonstrated  a moderate free radicals scavenging observed through the 2,2-diphenyl-1-picrylhydrazyl (DPPH) spectrophotometric method and anti-elastase activities in inhibited Alpha-1 antitrypsin in initiation of inflammation.

Application of Anise essential oil also displayed a significant effect in ameliorated the production of nitric oxide (NO) and prostaglandin E2 (PGE2) by activated macrophages in facilitated production of inflammatory cytokines in response to lipopolysaccharide (LPS) injection in dose dependent manner.



These results suggested that  essential oil isolated from anise exerts a strong antioxidant effect in inhibited oxidative stress through ameliorated production of reactive oxygen species in initiated chain reaction activities to precipitated expression of iNOS and COX-2 proteins in production of nitric oxide and prostaglandin E2 (PGE2) to facilitate localized inflammation and elicit pyrexia, pain sensation.

Further more, application of essential oil also demonstrated a cytotoxic effects in protected skin against inflammation observed by colorimetric MTT assays  in human dermal fibroblast and keratinocyte HaCaT in skin cells.

Additionally, in the study of anethole with different doases of 125, 250, and 500 mg/kg on the development of paw oedema and mechanical hypernociception, researchers at the Universidade Estadual de Maringá indicated that the bioactive compound displays a therapeutic effect in exhibited anti inflammatory effect through inhibited the levels of the cytokines tumor necrosis factor-α (TNF-α), a cell signaling protein (cytokine) involved in systemic inflammation in the acute phase of infection  and interleukin-1β (IL-1β), a cytokines with function in regulation of immune and inflammatory responses to infections or sterile insults and interleukin-17 (IL-17), acytokine produced by a group of T helper cell in response to local inflammation and myeloperoxidase, a oxidative enzyme activity.

Interestingly, injection of anethole reduced inflammatory expression of paw oedema without altering prostaglandin E2, plasma AST and ALT levels. These result suggested that the bioactive compound did not cause any liver toxicity according to the histological profile of liver tissue.

The efficacy of Anise anethole isolated from star Anise in reduced risk of chronic inflammatory related diseases are supported by the study of BALB/C mice intraperitoneally administered anethole at dose of 62.5, 125, 250, or 500 mg/kg 1 h before intratracheal treatment with LPS (1.5 mg/kg) and sacrificed after 4 h conducted by the Dr. Kang P and colleagues.

The injection of anethole exerted a strong anti inflammatory effect in inhibited the LPS in initiated the production of inflammatory mediators such as matrix metalloproteinase 9 (MMP-9), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), with dou function as inflammatory cytokine and an anti-inflammatory myokine, produced at the site of inflammation and in acute phase response and nitric oxide (NO) in bronchoalveolar lavage fluid.

The anti inflammatory effect of anethole also reduced in LPS-induced acute lung injure through suppressing the activation of NF-κB involved in cellular responses to stimuli such as stress, cytokines, free radicals by blocking IκB-α degradation. IκBα is a cellular proteins with function in inhibited the NF-κB transcription factor.


Taken together, Anise and its major compound anethole may be considered as a natural anti inflammatory and analgesic agent and combined with conventional medicine for treatment of chronic inflammatory related diseases.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN

Arthritis Is Curable

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Chemical composition, antioxidant, anti-elastase, and anti-inflammatory activities of Illicium anisatum essential oil by Kim JY1, Kim SS, Oh TH, Baik JS, Song G, Lee NH, Hyun CG.(PubMed)
(2) Antihypernociceptive activity of anethole in experimental inflammatory pain by Ritter AM1, Domiciano TP, Verri WA Jr, Zarpelon AC, da Silva LG, Barbosa CP, Natali MR, Cuman RK, Bersani-Amado CA.(PubMed)
(3) Anti-inflammatory effects of anethole in lipopolysaccharide-induced acute lung injury in mice by Kang P, Kim KY, Lee HS, Min SS, Seol GH.(PubMed)

Thursday, 8 February 2018

Food Therapy: Fennel and its Bioactive Anehtole in Attenuated Risk, Progression and Treatment of Periodontitis (PD)

Kyle J. Norton

Fennel may have a therapeutic effect in reduced risk, progression and treatment of periodontitis, some scientists suggested.

Periodontitis (PD) is a dental condition characterized by inflammation of the tissue around the teeth, resulted in shrinkage of the gums and loosening of the teeth if untreated.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc

In the investigation of bacterial Eschericia coli lipopolysaccharide (LPS, 30 µg) injected bilaterally into the palatal gingiva (3 µL/site) between the upper first and second molars every two days for 10 days in anesthetized rats, researchers found that application of trans-anethole, an bioactive found in fennel or ketoprofen (10 mg/Kg, i.p.) started 20 minute before LPS injection and continued for 10 days, exert a significant activity in decreased bacterial infection in induced symptoms of swelling, redness, pain,....

Further analysis suggested that both injections display significantly suppressed levels of interleukin 1 beta (IL-1β), a cytokine with function in regulation of immune and inflammatory responses to infections or sterile insults and tumor necrosis factor alpha (TNF-α ), a cell signaling protein involved in systemic inflammation in the acute phase of infection, in compared to Eschericia coli lipopolysaccharide treated rats group.

Moreover, researchers also indicated that bioactive tran-anethole demonstrates a similar effect to rats group treated with conventional medicine ketoprofen without inducing any side effects.

Also in the examine the continuous investigation of trans- anethole effect in modified periodontitis (PD) through the expression of the voltage-gated L-type Ca2+ channel and KCa2+ channels function, showed that administration of fennel bioactive compound also ameliorated the function of
of LPS in induced inflammatory molecules production by.inhibiting above channels expression.

Trans-anethole also attenuated the levels of substance P, bradykinin, histamine and serotonin in facilitated the production of pro-inflammatory factors such as IL-1β and TNF-α in initiated and progression of periodontitis.

Additionally, in the evaluation of chewing the fennel and cardamom seeds on plaque and salivary pH in 50 patients with periodontitis, aged 18-60 years attending V.S dental College and Hospital randomized in to two groups for chewing fennel and cardamom seeds. Salivary pH and plaque PH at baseline and immediately after chewing seeds for 5 minutes and after 10 min researchers indicated that the mean salivary PH scores at baseline, immediately and 10 minutes after chewing fennel seeds was 7.1, 7,3 and 7.5 and the mean salivary PH scores at baseline, immediately and 10 minutes after chewing cardamom seeds was 7.4 , 7.6 , 7.76, in compared to the the mean values of salivary PH scores at baseline, immediately and 10 minutes after chewing cardamom seeds was 7.4 , 7.6 , 7.76 and the mean plaque pH scores at baseline, immediately and 10 min after chewing fennel seeds was 7.4, 7.55, 7.53.

These findings suggested that chewing both fennel seeds and cardamom seeds are equally effective in increasing salivary and plaque pH.

Dr. Priti Basgauda Patil and colleagues said, "saliva, as a mirror of oral and systemic health, is a valuable source for clinically relevant information because it contains biomarkers specific for the unique physiologic aspects of periodontal diseases".

Increased salivary reduced levels of total free sialic acid are associated to decreased risk of periodontitis initiation.

Long term expression of low plaque pH is also associated to loss of mineral from the tooth, one of many factors in increased periodontitis risk.

These results postulated an important role of chewing the seeds can be used to lubricate and moisten the mouth, while at the same time providing caries protection to highly susceptible individuals with periodontitis (PD).

The evidences finding suggest that fennel and its bioactive anethole may have a potent inhibitory effect in reduced risk, progression and treatment of PD through suppression of pro-inflammatory molecules. However, ingestion of supplement should be taken with to avoid overdose in precipitated acute liver toxicity.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN

Arthritis Is Curable

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Anethole, a Medicinal Plant Compound, Decreases the Production of Pro-Inflammatory TNF-α and IL-1β in a Rat Model of LPS-Induced Periodontitis byJanet Moradi,a Fatemeh Abbasipour,a,b,* Jalal Zaringhalam,c Bita Maleki,a Narges Ziaee,a Amin Khodadoustan,d and Mahyar Janahmadic(PMC)
(2) EFFECT OF CHEWING FENNEL AND CARDAMOM SEEDS ON DENTAL PLAQUE AND SALIVARY pH – A RANDOMIZED CONTROLLED TRIAL bySwathi V., R. Rekha, Abhishek Jha, G. Radha, S. K. Pallavi and Gadde Praveen(INTERNATIONAL JOURNAL OF 
PHARMACEUTICAL SCIENCES AND RESEARCH)
(3) Saliva: A diagnostic biomarker of periodontal diseases by Priti Basgauda Patil and Basgauda Ramesh Patil(PMC)

The Best Studied Proof Foods in Induced Weight Loss and Weight Control

Kyle J. Norton

Today, the prevalence of extremely overweight and obese children caused by unhealthy diet and life style change over 2 decades of economic prosperity, in the South East Asian population has raised concerns of scientific community,

Overweight and obesity have reached epidemic proportions in many countries, affecting even younger age populations inducing economic burden in health care system for treatment of obesity-related disorders such as diabetes, hypertension, and cardiovascular diseases(1).

 One of six Malaysian are either extreme overweight or obese, according to Datin Paduka Santha Kumari, chairman of the Selangor branch of the Malaysian Diabetes Association and according to global health observatory, at least 2.8 million people die each year as a result of being overweight or obese, and an estimated 35.8 million (2.3%) of global DALYs are caused by overweight or obesity, worldwide(2).

Epidemiological studies, linking herbal medicine, foods and vitamins in preventing and treating these diseases have been inconclusive(a)/

Some researchers suggested that intake of certain herbal medicine may enhance appetite suppression.

According to the Georgetown University Medical Center, average daily food intake was decreased in some the herbal formulation, in comparison of the effectiveness among herbal formulation and a commonly available(3).

Other researchers insisted that using herbs and supplements to induce weight loss should be taken with care, as a considerable number of reports have been published on hepatotoxicity associated with herbal products attributed with weight-reducing properties(4)(5)(6)(7).

The College of Medicine, The Ohio State University insisted that various dietary, lifestyle, and psychologic factors are involved in the etiology of Prameha(including clinical conditions involved in obesity, prediabetes, diabetes mellitus, and metabolic syndrome), particularly in relation to disturbances of fat and carbohydrate metabolism(8), therefore, without effective management, obtaining a workable weight loss plan may be extremely difficult.

1. Oats
Oat is a species of cereal grain grown for its seed cultivated all over the world, especially in Scotland and England. Normally, oat is planted in the poor soil after crops are harvested in the Fall(30).

Oat, rich in beta-glucan, may hold a magic power in regulated metabolism and hepatoprotective effect.

According to Chung-Shan Medical University, consumption of oat reduced obesity, abdominal fat, and improved lipid profiles and liver functions with no adverse effects(31).

 Whole-grain ready-to-eat oat cereal, in a randomized study of 144 free-living, overweight and obese adults (N=204, body mass index 25 to 45) with baseline LDL cholesterol levels 130 to 200 mg/dL, exerted significantly favorable effects on fasting lipid levels and waist circumference(32).

Other study suggested that at-derived beta-glucan, combined with moderate exercise also improved lipid profile and factlitated a decrease in weight(33).

2. Salmon
Salmon is the common name for Salmonidae,  born in fresh water, migrated to the ocean, then travelling thousands of miles in the deep sea cold water throughout their life cycle and within five years returning to the exacted location where they were born to reproduce and die(34).

Dietary salmon oil, in rat study showed to reduce weight loss of CXB-E and -H tested mice, but induced with weight gain in recombinant inbred strains.

This findings may suggest that body weight response to salmonoil feeding is controlled by multiple genes(35).

A novel oral form of salmoncalcitonin (sCT), according to the study at Nordic Bioscience, hold a profound and positive effect in improved fasting and postprandial glycemic control and insulin sensitivity and may be considered as a promising agent for treatment of obesity-related insulin resistance and type 2 diabetes patients(36)(37).

3. Brown rice
Brown rice or unpolished rice is a kind of whole, natural grain with very brown color with only the outermost layer of the rice kernel are removed, thus preventing the lost of nutrients(38).

The study of the weigh effect of brown rice on metabolic parameters in type 2 diabetes, showed a positive effect brown rice(LB) of consumption in decreased waist circumference in tested subjects(39).

In a randomized study of forty women between 20 and 35 years of age to compare white rice and mixed rice in weight control, including brown rice, indicated that meal replacement with mixed rice was superior in replaced white rice in weight control and improved antioxidant enzyme activity(40).

4. Chicken
Chicken are domesticated fowl belongings to the subspecies of Gallus domesticus, raised all over the world for its delicious meats and eggs with tons of nutrients(41).

In the comparison of weight loss and total lipid profile changes in overweight women consuming beef or chicken, researchers at Rippe Lifestyle Institute, Shrewsbury showed that weight loss and improved lipid profile can be accomplished through diet and exercise, regardless to dietary protein source including lean beef or chicken(42).

But the study at University of Navarra, showed an opposite result of weight loss and improved lipid profile in participants with frequent consumption of selenium-enriched chicken meat(43). The efficacy in reduced weight loss was probably associated to the presence of antioxidant selenium in the meat.

5. Water
According to Virginia Tech, consuming 500 ml water prior to each main meal may lead to greater weight loss than a hypocaloric diet alone in middle-aged and older adults, because water intake expressed an acutely reduced meal energy intake(EI)(44). However, these result did not apply to younger subjects(45).

The Choose Healthy Options Consciously Everyday (CHOICE) randomized clinical trial, suggested that replacing caloric beverages with water or diet beverages induced 2% to 2.5% weight loss(46).

6. Nuts
Dietary consumption of nuts with rich sources of multiple nutrients is associated with health benefits and weight loss, epidemiologically.

Pistachio nuts, a member of the cashew family, can be consumed as a portion-controlled snack for individuals restricting calories to lose weight without concern that pistachios will cause weight gain (48).

But in well-controlled nut-feeding trials, no changes in body weight were observed(47).

7. Green tea
Green tea containing more amount of antioxidants than any drinks or food with the same volume is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world.

According to Maastricht University, caffeine intake and green tea supplementation are associated to improve weight maintenance, partly through thermogenesis and fat oxidation, in a randomized placebo-controlled double blind parallel trial in 76 overweight and moderately obese subjects(49).

Catechins, the antioxidants found abundantly in green tea, significantly decreased body weight and  maintained body weight after a period of weight loss, depending to the moderators of habitual caffeine intake and ethnicity(50).

Contrast to the above studies, in a high-protein diet, green tea-caffeine mixture, failed to exert the same effect on body weight maintenance(51).

8. Coffee
Coffee made from the roasted seeds of the genus Coffee, belongings to the family Rubiaceae native to southern Arabia.

In a randomized, double-blind, placebo-controlled, linear dose, crossover study, green coffee extract, consistent with human and animal studies and a meta-analysis exhibited an effective nutraceutical in reduced weight in pre obese adults(52).

Mannooligosaccharides (MOS), extracted from coffee, expressed a potential functional use for weight management and improvement in adipose tissue distribution, but varying in gender(53)

Unfortunately, green coffee extract (GCE), according to University of Exeter, in reviews of the effect against weight loss of existed data, showed a significant poor methodological quality and suggested that more rigorous trials are needed to assess the usefulness of GCE as a weight losstool(54).

 Other study reported a case of Brazil Potent slimming coffee and some weight-loss products may be contaminated with sibutramine(55).

Taken together. we can conclude that certain foods may hold magic functions in reduced and managed weight loss for obese individual but weight loss can not be in the expenses of intake of nutrients(30a).

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN


Arthritis Is Curable

You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss

A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author BiographyBy Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

References
(1) Rising Burden of Obesity in Asia by Ambady Ramachandran and Chamukuttan Snehalatha(Journey of Obesity)
(2) Obesity - Situation and trends(WHO)
(3) Influence of a combination of herbs on appetite suppression and weight loss in rats by Talpur NA1, Echard BW, Manohar V, Preuss HG.(PubMed)
(4) [Hepatotoxicity induced by herbs and medicines used to induce weight loss].[Article in Spanish]by Herrera S1, Bruguera M.(PubMed)
(5) A case report of adult lead toxicity following use of Ayurvedic herbal medication by Breeher L1, Gerr F, Fuortes L.(PubMed)
(6) [Chronic lead intoxication associated with Ayurvedic medication].[Article in Dutch] by Kanen BL1, Perenboom RM.(PubMed)
(7) Potential toxicity of caffeine when used as a dietary supplement for weight loss by Pendleton M1, Brown S, Thomas C, Odle B.(PubMed)
(8) Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: a randomized controlled trial by Hackman RM1, Havel PJ, Schwartz HJ, Rutledge JC, Watnik MR, Noceti EM, Stohs SJ, Stern JS, Keen CL.(PubMed)
(30) #Healthy #Foods - Oats ((Avena sativa) (Health tips for better living and living health)
(31a) Association between mood and diet quality in subjects with metabolic syndrome participating in a behavioural weight-loss programme: A cross-sectional assessment by Perez-Cornago A, Zulet MA, Martinez JA.(PubMed)
(31b) Dietary quality-adherence to the dietary guidelines in Tehranian adolescents: Tehran Lipid and Glucose Study by Mirmiran P1, Azadbakht L, Azizi F.(PubMed)
(31) Oat prevents obesity and abdominal fat distribution, and improves liver function in humans by Chang HC1, Huang CN, Yeh DM, Wang SJ, Peng CH, Wang CJ.(PubMed)
(32) Whole-grain ready-to-eat oat cereal, as part of a dietary program for weight loss, reduces low-density lipoprotein cholesterol in adults with overweight and obesity more than a dietary program including low-fiber control foods by Maki KC1, Beiseigel JM, Jonnalagadda SS, Gugger CK, Reeves MS, Farmer MV, Kaden VN, Rains TM.(PubMed)
(33) Oat-derived beta-glucan significantly improves HDLC and diminishes LDLC and non-HDL cholesterol in overweight individuals with mild hypercholesterolemia, Reyna-Villasmil N1, Bermúdez-Pirela V, Mengual-Moreno E, Arias N, Cano-Ponce C, Leal-Gonzalez E, Souki A, Inglett GE, Israili ZH, Hernández-Hernández R, Valasco M, Arraiz N.(PubMed)
(34) #Healthy #Foods - Seafoods - Salmon (Healthy tips for better living and living health)
(35) Genetically determined body weight loss in mice fed diets containing salmon oil by LeBoeuf RC1, Veldee MS.(PubMed)
(36) Oral salmon calcitonin improves fasting and postprandial glycemic control in lean healthy rats by Feigh M1, Nielsen RH, Hansen C, Henriksen K, Christiansen C, Karsdal MA.(PubMed)
(37) A novel oral form of salmon calcitonin improves glucose homeostasis and reduces body weight in diet-induced obese rats by Feigh M1, Henriksen K, Andreassen KV, Hansen C, Henriksen JE, Beck-Nielsen H, Christiansen C, Karsdal MA.(PubMed)
(38) #Healthy #Foods - Whole Grain - Brown rice or Hulled rice's(Health tips for beter living and living health)
(39) Intake of brown rice lees reduces waist circumference and improves metabolic parameters in type 2 diabetes by Kim TH1, Kim EK, Lee MS, Lee HK, Hwang WS, Choe SJ, Kim TY, Han SJ, Kim HJ, Kim DJ, Lee KW.(PubMed)
(40) Meal replacement with mixed rice is more effective than white rice in weight control, while improving antioxidant enzyme activity in obese women by Kim JY1, Kim JH, Lee da H, Kim SH, Lee SS.(PubMed)
(41) #Healthy #Foods - Chicken (Gallus gallus domesticus)(Health tips for btter living and living health)
(42) Weight loss and total lipid profile changes in overweight women consuming beef or chicken as the primary protein source by Melanson K1, Gootman J, Myrdal A, Kline G, Rippe JM.(PubMed)
(43) Frequent consumption of selenium-enriched chicken meat by adults causes weight loss and maintains their antioxidant status by Navas-Carretero S1, Cuervo M, Abete I, Zulet MA, Martínez JA.(PubMed)
(44) Water consumption increases weight loss during a hypocaloric diet intervention in middle-aged and older adults by Dennis EA1, Dengo AL, Comber DL, Flack KD, Savla J, Davy KP, Davy BM(PubMed)
(45) Pre-meal water consumption reduces meal energy intake in older but not younger subjects by



Van Walleghen EL1, Orr JS, Gentile CL, Davy BM.(PubMed)
(46) Replacing caloric beverages with water or diet beverages for weight loss in adults: main results of the Choose Healthy Options Consciously Everyday (CHOICE) randomized clinical trial by Tate DF1, Turner-McGrievy G, Lyons E, Stevens J, Erickson K, Polzien K, Diamond M, Wang X, Popkin B.(PubMed)
(47) Nut consumption and body weight by Sabaté J.(PubMed)
(48) Pistachio nuts reduce triglycerides and body weight by comparison to refined carbohydrate snack in obese subjects on a 12-week weight lossprogram by Li Z1, Song R, Nguyen C, Zerlin A, Karp H, Naowamondhol K, Thames G, Gao K, Li L, Tseng CH, Henning SM, Heber(PubMed)
(48) Impact of peanuts and tree nuts on body weight and healthy weight loss in adults by Mattes RD1, Kris-Etherton PM, Foster GD.(PubMed)
(49) Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation by Westerterp-Plantenga MS1, Lejeune MP, Kovacs EM.(PubMed)
(50) The effects of green tea on weight loss and weight maintenance: a meta-analysis by Hursel R1, Viechtbauer W, Westerterp-Plantenga MS.(PubMed)
(51) Green tea catechin plus caffeine supplementation to a high-protein diet has no additional effect on body weight maintenance after weight loss by Hursel R1, Westerterp-Plantenga MS.(PubMed)
(52) Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects by Vinson JA1, Burnham BR, Nagendran MV.(PubMed)
(53) A weight-loss diet including coffee-derived mannooligosaccharides enhances adipose tissue loss in overweight men but not women, by St-Onge MP1, Salinardi T, Herron-Rubin K, Black RM.(PubMed)
(54) The use of green coffee extract as a weight loss supplement: a systematic review and meta-analysis of randomised clinical trials by Onakpoya I1, Terry R, Ernst E.(PubMed)
(55) [Life-threatening psychosis caused by using sibutramine-contaminated weight-loss coffee].

[Article in Dutch] by Bertholee D1, ter Horst PG, Wieringa A, Smit JP.(PubMed)

Wednesday, 7 February 2018

Herbal Therapy: Green Tea in Ameliorated Symptoms, Progression and Treatment of Tendinitis

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced symptoms, progression and treatment of tendinitis, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Tendinitis is a condition characterized by inflammation of a tendon as a result of overuse, infection or rheumatic disease.

According to the study of the effect of GT and/or glycine in the diet on tendinitis on Wistar rats, randomly divided into seven groups (G): control group (C); G1 and G4, tendinitis; G2 and G5, tendinitis supplied with GT; and G3 and G6, tendinitis supplied with GT and a glycine diet for 7 or 21 days, respectively, group with  tendinitis treated with green tea demonstrated a significant effect in enhanced collagen stablility through expression of hydroxyproline in compared to other groups.

Furthermore, GT and glycine alone treated groups showed an increased activity of metalloproteinase-2 MMP-2 levels which has been associated to the healing process of the fibrous connective tissue in tendinitis patients.

In compared to control and non GT treatment groups, application of green tea or GT+ gyycine group displayed a statistical significance in the decreased muscle retardation.

After taking into account of other co founders, Dr. Vieira CP, the lead author said, " GT + a glycine diet has beneficial effects that aid in the recovery process of the tendon after tendinitis".

Interestingly, in the study investigated the remodeling effects of green tea and glycine in the myotendinous junction (MTJ) of male Wistar rats with tendinitis, randomly divided into five groups: animals without tendinitis and animals with tendinitis; animals with tendinitis supplied with green tea; animals with tendinitis supplied with a glycine diet; animals with tendinitis supplied with a green tea and glycine diet, researcher found that all treatment groups exerted a profound effect in regulated the activity of metalloproteinases (MMP)-2 with function in remodeling the tendon after tendinitis, MMP-8 and -9 which are associated to remodeling tissue expression in the disease progression  and induced the synthesis of type I collagen regulation by cell spreading, platelet-derived growth factor and interactions with collagen fibers.

Moreover, rats groups treated above application also demonstrated an increase of glycosaminoglycans, in stimulated the regenerative processes, while maintaining host cell characteristics and function and non-collagenous proteins in modulated the development of fine fibrils presented in collagen fibers of connective tissue

Additionally, the combination of green tea and glycine also modulated the inflammatory process through stimulated production of anti inflammatory factors and induced the synthesis of the elements, such as extra cellular matrix involved in the post-lesion recovery of the tissue.

These results indicated an important recovery from injured tendon through improving the compaction of the collagen molecules and inducing assembly of early collagen fibers, in green tea and glycin treated groups.

After considering of all cofounders, researchers and colleagues at the Anat Rec said, " each region of the inflamed tendon can exhibit different responses during the treatment and therefore, modify its extracellular matrix components to facilitate recovery and repair".

The information findings suggested that green tea may be considered as a function food for reduced symptoms, progression and used with glycin and conentional standard medicine for treatment of
tendinitis. However, intake of supplement for treatment of  tendinitis should be taken with exceptional care in prevented toxicity.


For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Green Tea and Glycine Modulate the Activity of Metalloproteinases and Collagen in the Tendinitis of the Myotendinous Junction of the Achilles Tendon by Vieira CP1, De Oliveira LP2, Da Ré Guerra F3, Marcondes MC2, Pimentel ER2.(PubMed)
(2) Green tea and glycine aid in the recovery of tendinitis of the Achilles tendon of rats by Vieira CP1, Guerra Fda R, de Oliveira LP, Almeida MS, Marcondes MC, Pimentell ER.(PubMed)

Herbal Therapy: Green Tea in Alleviated Symptoms and Treatment of Chronic Back Pain

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in ameliorated symptoms and treatment of chronic back pain, some scientists suggested.

Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Back pain is a condition of Musculo-Skeletal disorders(MSDs) of the spine caused by various factors, including bone fractures, muscle or ligament injure, arthritis, herniated discs. aging,....

Application of biologically active polyphenol epigallocatechin 3-gallate (EGCG) demonstrated a significant effect in reduced back pain through facilitate anti inflammatory and anti-catabolic activity in patients with intervertebral disc (IVD) disease due to age-related changes in the adult disc in induction of back pain.

According to the study by the Institute for Biomechanics (D-HEST), ETH Zurich ingestion of green tea EGCG on back pain patients, human IVD cells isolated from patients undergoing surgery due to degenerative disc disease (n = 34) and cultured in 2D or 3D indicated that the phytochemical inhibited levels of inflammatory response activated by IL-1β, a cytokine protein produced by macrophages, with function in contributed to the inflammatory pain hypersensitivity in the site of infection observed by the reverse transcription polymerase chain reaction (qRT-PCR), western blotting, enzyme-linked immunosorbent assay (ELISA), immunofluorescence and transcription factor assay.
Further more, application also displayed a strong effect in reduced expression of
p38 mitogen-activated protein kinases in mediated inflammatory factors of IL-1β in responded to stress stimuli.

Also, according to the Institute for Biomechanics (D-HEST), in the investigation of the analgesic properties of EGCG, by the von Frey filament test in Sprague-Dawley rats (n = 60), green tea EGCG injection also significantly inhibited the expression of pro-inflammatory mediators as expressed in above and reduced matrix metalloproteinases which have been found to associate to pro-inflammatory cytokines, chemokines and other proteins to regulate varied aspects of inflammation and immunity.

Moreover, in the radiculopathic pain component, researchers also indicated that EGCG inhibited the inflammation in precipitated back pain through modulation of the activity of IRAK-1 in glucose metabolism and insulin sensitivity in skeletal muscle and p38, c-Jun N-terminal kinases (JNK) and nuclear factor NF-κB in responded to stress stimuli in mediated production of pain related pro inflammatory cytokines such as IL-1β.

Some researchers postulated that back pain may also induced by muscle degeneration and impairment nerve injury, leading to increased levels of reactive oxygen species in induced tissue apoptosis.

In crushing of the sciatic nerve induced back pain in tested animal, application of green tea EGCG improved motor function in the toe spread and foot positioning and gain in the percentage motor deficit.

More importantly, EGCG expressed a significant effect in recovery of sensory innervation in neuropathic pain-like syndrome and improvement of muscle tissues from injured limb with severe histopathological alterations at the end of week 3 post-surgery in treated animals.

According to the RT-PCR assay, EGCG treatment also normalizing the Bax/Bcl-2 ratio, abnormal ratio of the Bax/Bcl-2 ratio has been found to associate in induction of nerve cell apoptosis as well as inhibited levels of p53 with function in regulated the cell death cycle at days 3 and 7 post-surgery.

These results demonstrated a important effect of green tea EGCG in enhanced functional recovery, protected muscle fibers from cellular death, and improved morphological recovery in skeletal muscle after nerve injuries.

However, in the study of caffeine activity in the modulation of pain perception in chronic pain states of 131 patients with chronic low back pain (64 men and 67 women; mean age = 42.1 years; mean duration of pain = 6.1 years) referred to a multidisciplinary pain clinic over a 2-year period, researchers found that in compared to caffeine intake regardless concentration, cffeine is not related to the global experience of pain and disability in patients with chronic low back pain, although high caffeine use may be embedded in a context of other unhealthy life-style behaviors.

Taken together, green tea and its bioactive component epigallocatechin 3-gallate (EGCG) may be considered as functional food in reduced back pain caused by physical damage of the spine and injured nerve cells. Intake of green tea supplement should be taken exceptional care as some cases of liver acute toxicity have been reported in medical literature.


For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Epigallocatechin 3-gallate suppresses interleukin-1β-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats by Krupkova O1, Sekiguchi M, Klasen J, Hausmann O, Konno S, Ferguson SJ, Wuertz-Kozak K.(PubMed)
(2) (-)-Epigallocatechin-3-gallate (EGCG) attenuates functional deficits and morphological alterations by diminishing apoptotic gene overexpression in skeletal muscles after sciatic nerve crush injury by Renno WM1, Al-Maghrebi M, Al-Banaw A.(PubMed)
(3) Caffeine and chronic low back pain by Currie SR1, Wilson KG, Gauthier ST.(PubMed)

Tuesday, 6 February 2018

Herbal Therapy: Green Tea and its Bioactive Egallocatechin-3-gallate (EGCG) in Reduced Risk, Progression and Treatment of Lupus

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced risk and treatment of systemic lupus erythematosus (SLE), some scientists suggested.

Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the body's immune system abnormal function in attacking healthy tissue in many parts of the body.

In the study of patient with lupus nephritis induced by SLE, researchers found that intake of green tea epigallocatechin-3-gallate (EGCG), the major bioactive polyphenol displayed a strong antioxidant effect in reduced expression of reactive oxygen species in activated the activity of proinflammatory factors nuclear factor-kappa B (NF-κB), a protein complex mediated inflammatory responses under stress stimuli in induction of inflammation.

Further analysis, also indicated that application of green tea EGCG decreased levels of interleukin (IL)-1β and IL-18, the inflammatory cytokines which were found to have a closed link to inflammation and correlated with systemic lupus erythematosus (SLE).

Moreover, in the evaluation of 12-week-old New Zealand black/white (NZB/W) F1 lupus-prone mice treated daily with EGCG by gavage until sacrificed at 34 weeks old, researchers at the National Defense Medical Center found that green tea ingestion exerts a strong effect in prevented proteinuria, renal function impairment, and severe renal lesions through increased repression of antioxidant mediated by renal nuclear factor E2-related factor 2 (Nrf2) and enhanced natural antioxidant of glutathione peroxidase produced by the host body.

The over expression of antioxidant activity participated by green tea EGCG also ameliorated the free radical in expression of renal oxidative stress, through reduced NF-κB activation in production of inflammatory cytokine and increased anti inflammatory NLRP3 mRNA/protein expression and mature caspase-1, IL-1β, and IL-18 in response to inflammation caused by immune abnormal activity in systemic lupus erythematosus (SLE).

The result of the study also found that green tea EGCG also enhanced splenic regulatory T (Treg) cell activity in maintain immunologic homeo-stasis and inhibited autoimmunity.

Additional study of green tea, egallocatechin-3-gallate (EGCG) effect in lupus, researchers suggested that green tea exerted a profound anti-inflammatory activity on immune cells through inhibiting the immune-stimulated phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway in attenuated inflammatory response.

In fact the expression of green tea EGCG also reduced the production of nitric oxide (NO) and other inflammatory mediators including iNOS expression, supernatant NO and interleukin-6 in initiation of mesangial cells inflammation in the kidney under abnormal immunity in patients of systemic lupus erythematosus (SLE).

Dr. Peairs A, after taking into account of other co founders said, " EGCG attenuated inflammation in MRL/lpr mouse mesangial cells via the PI3K/Akt/mTOR pathway" and "EGCG to regulate inflammation and control autoimmune disease".

The result of above differentiation were supported by the study conduced by the Medical College of Georgia in the evaluation of the green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), affects autoantigen expression in human cells.

Dr. Hsu S, at the end of the experiment, postulated that green tea bioactive polyphenols EGCG inhibited the transcription and translation of major autoantigens, including SS-B/La, SS-A/Ro, coilin, DNA topoisomerase I, and alpha-fodrin through its anti inflammatory and anti apoptotic tissue effects.

Taken togther, green tea and its bioactive component egallocatechin-3-gallate (EGCG) may be considered  as a functional food in reduced risk and progression and combined with conventional therapy for treatment of systemic lupus erythematosus (SLE). However, intake of green tea supplement should be taken with care in prevented liver acute toxicity.


For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation by Tsai PY1, Ka SM, Chang JM, Chen HC, Shui HA, Li CY, Hua KF, Chang WL, Huang JJ, Yang SS, Chen A.(PubMed)
(2) Epigallocatechin-3-gallate (EGCG) attenuates inflammation in MRL/lpr mouse mesangial cells by Peairs A1, Dai R, Gan L, Shimp S, Rylander MN, Li L, Reilly CM.(PubMed)
(3) Inhibition of autoantigen expression by (-)-epigallocatechin-3-gallate (the major constituent of green tea) in normal human cells by Hsu S1, Dickinson DP, Qin H, Lapp C, Lapp D, Borke J, Walsh DS, Bollag WB, Stöppler H, Yamamoto T, Osaki T, Schuster G.(PubMed)