Herbal Therapy: Green Tea In Reduced Risk of Subarachnoid Hemorrhage (SAH)

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced risk hemorrhage, some scientists suggested.
Green tea, is a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Hemorrhage is a condition of vessel rupture, leading to bleeding within the brain tissue.

In the investigation of the effects of green tea polyphenols intake and the risk of subarachnoid hemorrhage (SAH) study, researchers at the Henan Institute of Science and Technology found that

administration of green tea reduced early onset of SAH through prevented alteration of mitochondrial membrane potential to basal level.

Further analysis, also suggested that green tea pre-treatment also decreased production of Adenosine triphosphate(APT) content, a vasoactive compound found in high concentrations after subarachnoid hemorrhage and the cytochrome c level to induced cell death in the brain cortex after 12 hours in the tested models.

These result suggested that green tea administration not only exerted a significant neuro protective effect against polarization of mitochondrial membrane potential and prevented production of certain proteins and enzymes in induction of brain damage.

Indeed, over the course of study of a total of 180 mice, 8 (4.4%) died during the experiment, 5 (8.3%) in the SAH group, 3 (5.0%) in the tea polyphenols pretreated model, and 0 in the control group. 

And the differentiation of the neurological scores observed for mice with SAH was significantly lower than that of the sham group from 6 h to 72 h after SAH occurrence..

Additionally, pretreatment with tea polyphenols expressed a significant decrease activity lactic acid dehydrogenase (LDH) levels in the blood stream,  an indication of brain tissue injured and damage in compared to the untreated SAH group.

Dr. Mo H, the lead scientist after taking into account of others con-founders, said, "After pretreatment with tea polyphenols, the neurological outcome was also improved(through various implications)".

Interestingly, in a designed to determine the effects of consumption of green tea in reduced risk for subarachnoid hemorrhage (SAH) in a case-control study consisting incident SAH cases of n=201 matched by age (+/-2 years) and gender to hospital (n=201) and community controls (n=201) from April 1992 to March 1997, researchers at the Aichi Prefectural College of Nursing and Health suggested that habital green tea consumption is associated inversely in risk of subarachnoid hemorrhage (SAH).

People who drank one or more cup of green tea per day scored a significant lower risk of 60.3% in compared non tea drinking group of 70.9%.

More specifically, testing subjects who consumed  <1, and >or=1 time per day showed a strong ameliorated risk with adjusted over all risk ratio of  0.74  and 0.56 respectively, in compared non daily green tea drinkers.

Okamoto K suggested that risk of subarachnoid hemorrhage (SAH) is significant reduced linearly depending to numbers of cup of green intake per day.

Taken together, green tea as powerful antioxidant activity may be considered as functional food in reduced risk of subarachnoid hemorrhage (SAH) and used combination with standard medicine for post treatment of the incidence.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Neuroprotective effect of tea polyphenols on oxyhemoglobin induced subarachnoid hemorrhage in mice by Mo H1, Chen Y, Huang L, Zhang H, Li J, Zhou W.(PubMed)
(2) Habitual green tea consumption and risk of an aneurysmal rupture subarachnoid hemorrhage: a case-control study in Nagoya, Japan by Okamoto K1.(PubMed)
(3) Dietary antioxidant intake and risk of an aneurysmal rupture subarachnoid hemorrhage in Japan by Okamoto K1, Horisawa R.(PubMed)

Alternative Therapy: Yoga, the Best Form of Exercise in Reduced Risk of Oxidative Stress-Related Diseases

Kyle J. Norton (Scholar, All right reserved)


Scientists may have found a safe and low cost home base exercise in increased antioxidants in fighting against free radical and inflammations in infectious expression, according to studies published online public medical library.

Yoga, the ancient technique for harmonized external and internal body wellbeing, through breath control, meditation, bodily movement and gesture..... has been best known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In the study on healthy volunteers recruited from among university students, divided into two groups: a control (no yoga intervention, n=13) group and a yoga (n=12) group with practice with an instructor for 90 minutes once a week spread over 12 weeks, with recommendations to practice daily at home for 40 minutes with the help of a DVD, researchers indicated that free radical expression of serum levels of nitric oxide, F2-isoprostane, and lipid peroxide were significantly decreased in yoga group due to yoga in stimulated production of antioxidants in interception of free radicals unstable configuration in release of electrons before exerting chain reaction in compared to control.

In deed, yoga breathing and meditation enhanced the the balance of body and mind, caused by the stress, thus improving the blood circulation to nourish the cells in the body with nutrients and oxygen and keep the free radicals in check which are present in our body through daily activities such as breathing, exposure to the environment, food intake,....

The environment superoxide anion, hydrogen peroxide and extremely reactive hydroxyl radical in induction of oxygen toxicity are also inhibited by antioxidant over expression in yoga group.

Yoga intervention also reduced stress in exhibited nervous system sympathetically in production of hormone catecholamines to induce cytotoxic free radicals formation in initiated disease progression.

Furthermore, yoga exercise increased digestive system in generated antioxidants such as serum total glutathione (GSH) contents, GSH-peroxidase, and GSH-s-transferase through food intake to balance the over expression of ROS activities but also reduced stress implication in production of Malondialdehyde (MDA)which is considered a marker of oxidative stress in compared to control, observed by the initial blood samples obtained from both the group before and after yoga training.

Additionally, researchers also found that beside improved antioxidant explicitly, yoga group also significantly increased immune function in protection of our body against damage to the body during the acute phase of infection by regulated production of anti inflammatory mytokines and pro inflammatory cytokines in ameliorated symptoms of inflammation.

More importantly, unlike the other types of exercise, yoga group also demonstrated a significant lower levels of nitric oxide, a free radical with duo activity but in excess, it can cause certain damage to the body tissue.

Dr. Lim SA , the led author said, "Regular yoga practice remarkably attenuated oxidative stress and improved antioxidant levels of the body".

In a study of healthy male volunteers from the Indian Navy, divided into two groups--a yoga (n = 30) group and a control (n = 21) group with yoga group trained in yoga for 6 months and the schedule consisted of prayers, asana, pranayama, and meditation and the control group practiced routine physical training exercise for 6 months, researchers also found the similar conclusion as mentioned in the above study.
Yoga participated group demonstrated a reduced glutathione level at the beginning but increased significantly at the end of training in compared to control group.

Interestingly, in compared to the levels of antioxidant in the both groups researchers surprisingly found that total antioxidant status were increased strongly in the yoga group but decreased significantly in the control group.

After taking into account of other co founders, researchers recommended. "Regular practice of yoga can maintain or improve antioxidant level of the body".

Due to yoga effect in promoted antioxidant and reduced oxidative stress through improved immune activities, some researchers suggested yoga may be used as an home base excise to promote healthy lifestyles (balanced diet and moderate intensity exercise) in vulnerable populations, such as menopausal women, in prevention of aging induced oxidative stress-related diseases, according to the study of an urban community in Bangkok (Thailand) between May and August 2007 conducted by the Université de Nice Sophia-Antipolis, in premenopausal and postmenopausal women.

Taking altogether, the findings showed that yoga indeed can be considered as an integrated form of exercise to improve antioxidant expression in reduced chronic illness caused by oxidative stress.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Regular Yoga Practice Improves Antioxidant Status, Immune Function, and Stress Hormone Releases in Young Healthy People: A Randomized, Double-Blind, Controlled Pilot Study.
Lim SA1, Cheong KJ1.(PubMed)

(2) Improvement of glutathione and total antioxidant status with yoga by Sinha S1, Singh SN, Monga YP, Ray US.(PubMed)

(3) Dietary intakes and antioxidant status in mind-body exercising pre- and postmenopausal women by Palasuwan A1, Margaritis I, Soogarun S, Rousseau AS.(PubMed)
(4) Effect of yoga on Free radical and Antioxidant status in Healthy Adults Mahalakshmamma Vandavasi 1 , Puli Sreehari 2 , Chintala Durga Sukumar(ORIGINAL ARTICLE)

Herbal Therapy: Herbal Anise In Expression of Antidepressant-like Activity

Kyle J. Norton 

Anise may have a potential and substantial effect in reduced risk and treatment of dpression, some scientists suggested.

Anise is a flowering plant ofthe species of Pimpinella anisum, genus Pimpinella, belonging to the family Apiaceae native to to Egypt and the Mediterranean region, used in traditional herbal medicine as fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, ....

Chemical comstituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

Depression is a condition of mood disorder. affecting the patients feel, think, and handle daily activities.

According to statistic of The National Institute of Mental Health, approximately, 16 million adults had at least one major depressive episode in 2012 in the United States, a 6.9 percent of the population.

In the evaluation of the herbal Anise aqueous and ethanol extracts antidepressant-like effect in mice with several different doses of 50, 100 and 200 mg/kg in compared to the standard medicine Fluoxetine at dose of 30mg/kg and and imipramine at dose of 20mg/kg, researchers at the joint study lead by the Azad University showed that except the dose at 50mg/kg of aqueous extract, application of other doses demonstrated a linearly significant improvement of mobility times.

Further analysis also found that all doses from Anise extract increased the swimming time dose-dependently, without any significant change in climbing time in tested mice similar to those of Fluoxetine and in compared to aqueous extract.

Moreover, Fluoxetine and imipramine expressed a strong decreased immobility time in both tests in contrast to imipramine increased climbing time without any significant change in swimming time.

The result suggested that both extracts in dose higher than 50mg/kg display antidepressant-like activity similar to that of fluoxetine through improved mobility of depressed mice as inactivity is considered as one of major symptoms in patients with depression.  

As the depression progressed, patients demonstrated a behavior in making efforts to escape from society, eventually will exhibit immobility with reflection of psychological despair.

Dr. Shahamat Z the lead author said, " P. anisum possesses an antidepressant-like activity similar to that of fluoxetine, which has a potential clinical value for application in the management of depression".

Additionally, in the testing essential (volatile) oil and essential oil of Piper laetispicum antidepressant activity in compared to Fluoxetine as standard antidepressant drug and other natural remedies including Leaves-Bay, Curry, Coriander and Mint; Fruits-Star anise, Pepper, Cardamom, Caraway and Fennel; Seeds of Fenugreek, Mustard, Nutmeg and Black Cumin; and Underground stem-Onion, Garlic, Ginger and Turmeric; Miscellaneous-Clove, Cinnamon, Capsicum, Tamarind and Asafoetida, reserachers found that all participated essential oil, specially anise produced a significant reduction in immobility along with an increase in climbing behavior  similar to those of fluoxetine. 

The application of  essential oil caused a dose -dependent reduction( probably in dose less than 50 mg/kg) in immobility which is contracted to the above study and an increase in climbing at all studied doses in compared to control group.

However, the test may not take into effect in real life patients who need to be treated for at least several weeks before they experience any relief from expression of symptoms.

Further more, in the examine of the efficacy of anise oil, in removing the symptoms of mild to moderate depression in patients with irritable bowel syndrome of a total of 120 randomly assigned into 3 equal groups received anise oil, Colpermin, and placebo, at the end of the study, scientists showed that application of anise group exerted a continuously improvement of the syndrome in compared to the other 2 groups with some unknown mechanisms. 

Some researchers postulated that essential oil smell may have a profound effect to the brain in triggering emotional reaction in stimulating the limbic system in regulated autonomic and endocrine function, particularly, in response to emotional stimuli in expression of motivation and reinforcing behaviors.

 Additionally, the application of essential oil scent also have a direct influence in calming the central nervous system in ameliorated over production of certain hormones in reacted to the unfavorably emotional behaviors.

Taken together, Anise essential oil may be used as a secondary therapy to standard medicine in treatment of depression.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Evaluation of antidepressant-like effects of aqueous and ethanolic extracts of Pimpinella anisum fruit in mice by Shahamat Z1, Abbasi-Maleki S2, Mohammadi Motamed S3.(PubMed)
(2) Effectiveness of Anise Oil for Treatment of Mild to Moderate Depression in Patients With Irritable Bowel Syndrome. A Randomized Active and Placebo-Controlled Clinical Trial by Maryam Mosaffa-Jahromi, PharmD, PhD, Ali-Mohammad Tamaddon, PharmD, PhD, Suleiman Afsharypuor, PharmD, PhD, Alireza Salehi, MD, MPH, PhD, Seyed Hassan Seradj, PharmD, PhD, Mehdi Pasalar MD, MPH, PhD, Peyman Jafari, PhD, Kamran Bagheri Lankarani, MD (Journal of Evidence-Based Integrative Medicine)
(3) Essential oil isolation from culinary drugs and screening for antidepressant potential Mohib Abdul Jalil Khan , Imtiyaz Ansari, Amjad Ali Mohammad Iqbal Oriental College of Pharmacy, Navi Mumbai, Maharashtra- 400705, India.(INTERNATIONAL JOURNAL OF ADVANCES INPHARMACY MEDICINE AND BIOALLIED SCIENCES)
(4) The Forced Swim Test as a Model of Depressive-like Behavior by Roni Yankelevitch-Yahav, 1 , 2 Motty Franko, 2 Avrham Huly, 2 and Ravid Doron(PMC)

ntegrative

Alternative Therapy: Yoga, In Reduced Functional abdominal pain Frequency and Intensity

Kyle J. Norton 

According to studies online public medical library, yoga intervention may reduce risk and improve functional abdominal pain as a result of gastrointestinal (GI) disorders.

Functional abdominal pain is a condition of functional gastrointestinal (GI) disorders characterized by symptoms of pain associated with diarrhea and/or constipation

People with functional abdominal pain participated in yoga class are likely to experience less intensity of pain and pain frequency, some scientists suggested.

Yoga, the ancient technique for harmonized external and internal body wellbeings, through breath control, meditation, bodily movement and gesture..... has been best known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In the study of 20 children, aged 8-18 years, with irritable bowel syndrome (IBS) or functional abdominal pain (FAP) were enrolled and received 10 yoga lessons, researchers indicated the following results
*Yoga practice group of  the 8-11 year old group and the 11-18 year old group expressed a less pain frequency and pain was significantly decreased at the end of therapy
*The same above group also expressed a significantly decreased pain intensity
*The pain frequency and intensity also were reduced after 3 months of yoga participated.

Further assessment the study also found that yoga therapy also improves the quality of life score in all participants.

Although how yoga intervention in reduced abnormal pain are still unknown, some researchers suggested that it may be a result of yoga in initiated psychological effect in reduced correlated and interplayed of various aspects including physiological, psychological, and emotional factors which have been found to have strong implication in induction of abnormal pain.

More precisely, yoga mindfulness connected the physical body and mind exerted a profound effect in decreased stress in induction of emotion instability such as anxiety, irritable and anger through relaxing the central nervous system in production of certain hormone observed from the change of changes in gray matter concentration in brain regions involved in emotional regulation and arousal circuit, by MRI in the brain of children participated yoga.

Dr.Brands MM , the led author said, "yoga exercises are effective for children aged 8-18 years with FAP, resulting in significant reduction of pain intensity and frequency, especially in children of 8-11 years old."

Additionally, in support of the above analysis, researchers at the joint study led Jeroen Bosch Hospital conducted experience of 69 patients, ages 8 to 18 years, with abdominal pain-related functional gastrointestinal disorders (AP-FGIDs), randomized to standard medical care (SMC) complemented with yoga therapy (YT) or SMC alone with YT is a mixture of yoga poses, meditation, and relaxation exercises and given once a week in group sessions and SMC consisted of education, reassurance, dietary advice, and fibers/mebeverine, if necessary illustrated that
*Yoga group expressed a significant decrease of Pain intensity (pain intensity score) and frequency (pain frequency score)
* Researchers also notice that after 12 months., during the study, yoga group showed no significantly superior compared with SMC, but Subanalyses suggested other wise (significant greater reduction of PIS at 12 months in favor of YT)
* More importantly, yoga participants showed less school absence in compared to control

In the summary, Dr, Korterink JJ, the led author concluded, "At 1-year follow-up, YT in addition to standard care was superior compared with SMC according to treatment success, PIS, and reduction of school absence".

Surprisingly, yoga participated program created a self consciousness between body and mind, by bring back the presence and dealing the event positive way, thus improving children awareness of the symptom and actively seeking for help from their physicians.

Contrastively, in further concern of the psychological effect of yoga in functional abdominal pain, Dr. Abbott RA, the led author at the joint study led by the University of Exeter Medical School, in the review of the literature of CENTRAL, MEDLINE, Embase, eight other databases, and two trials registers with 18 randomised controlled trials (14 new to this version), reported in 26 papers, involving 928 children and adolescents with RAP between the ages of 6 and 18 years selected said, "yoga therapy compared to control, we found no evidence of effectiveness on (recurrent) pain intensity reduction post intervention (SMD -0.31, 95% CI -0.67 to 0.05; Z = 1.69; P = 0.09; 3 studies; 122 children; low-quality evidence)".

Taking altogether, the findings suggested that yoga may be considered as a secondary intervention combined with standard therapy for treatment of functional abdominal pain and Yoga intervention may be effective in treating patients with recurrent functional abdominal pain.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources

(1) A pilot study of yoga treatment in children with functional abdominal pain and irritable bowel syndrome by Brands MM1, Purperhart H, Deckers-Kocken JM.(PubMed)
(2) Yoga Therapy for Abdominal Pain-Related Functional Gastrointestinal Disorders in Children: A Randomized Controlled Trial BY Korterink JJ1, Ockeloen LE, Hilbink M, Benninga MA, Deckers-Kocken JM.(Pub Med)
(3) Psychosocial interventions for recurrent abdominal pain in childhood by Abbott RA1, Martin AE2, Newlove-Delgado TV1, Bethel A1, Thompson-Coon J1, Whear R1, Logan S1(PubMed).
(4) Yoga Therapy for Abdominal Pain-Related Functional Gastrointestinal Disorders in Children: A Randomized Controlled Trial yJudith J. Korterink, y Lize E. Ockeloen, z Mirrian Hilbink,(ORIGINAL ARTICLE: GASTROENTEROLOGY)

The Science of Legume: Black Beans In the Prevalence of Multiple Cancers' Risk

Kyle J. Norton


People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine, food therapy takes significant longer in times to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Epidemiological studies strongly suggested that intake of black bean may associate to reduced risk and treatment of various type of cancers(1)(2).

Cancer is a class of chronic condition characterized by the irregular cell growth in the body organs. Sometime, the cancer cells can spread to other tissues or organs depending to stages of cancer..

Black bean, a small roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

1. Liver Cancer
Liver cancer is a condition of the abnormal growth of the cells in the liver's tissue. According to statistics approximated 40,710 adults (29,200 men and 11,510 women) in the United States will be diagnosed with primary liver cancer this year.

According to the Stocking Hall, Cornell University, phytochemicals isolated from black bean such as triterpenoids, flavonoids, and other compounds exhibited antiproliferative activities against the HepG2 cells(3), the human liver cancer cell line.

The efficacy of black bean in ameliorated growth of liver cancer may be attributed to the presence of some potent antioxidants in expression of apoptosis.

Consumption of bean not only played a prominent role of gene expression(4) involved the regulation of gene Hspa8 in reduced risk of liver disease developed, but also addressed the important issue of attenuated hepatic stress or toxicity in rat model.

Increased bean consumption in rats exhibits changes indicative of hepatic damage, Dr. Daniell EL, the lead author said, "Dry bean (Phaseolus vulgaris L.) consumption is associated with reduced risk for a number of chronic diseases", such as liver cancer.

Dietary bean concentrations.is found to associate to the cholesterol 7α hydoxylase and UDP-glucuronosyltransferase genes(4) increased with connection to the development of liver cancer, in a dose-dependent manner.

2. Breast Cancer
Breast cancer in most cases, starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. but in rare instance, breast cancer may arise from other areas of the breast.

In the study of water-soluble condensed tannins isolated from black beans against Hs578T breast cancer cells, the preparation at 0.24-24 microM in dose-dependent induced cancer cell death by apoptosis but did not affect the growth of normal cells(5), as shown by observation assay.

The efficacy of water-soluble black bean condensed tannins at 24 microM in suppressed the breast caner cells(5) may be attributed to the phytochemical in reduced coagulation of remained blood in stimulated cancer cell migration and regulated the growth of breast tumor in formation of new blood vessels.

According to the National Taiwan University, fermentation product of soybean, black bean, and green bean mixture (BN999) showed a significant effect in inhibited the growth of human breast cancer AU565 cells in increased expression of multiple apoptotic regulators in induced apoptosis(6).

The fermentation product also exerted an impressive activity in induced apoptosis in various human cancer cells but not in normal human cells, Dr, Chia JS, the lead author insisted.

Dr. Dong M, the lead researcher at the Cornell University, in the finding of major phytochemicals of black bean which may have a powerful effect in treatment of breast cancer suggested, that out of newly found flavonoids, only 6 (5, 7, 8, 9, 11, 19, 20) of them showed potent antioxidant and antiproliferative activities.against MCF-7 human breast cancer cells(7).

3. Osteocarcinoma
Osteocarcinoma is a condition of bone cancer caused by irregular cell growth in bone, affecting mostly adolescents and young adults..

According to the The Chinese University of Hong Kong, hemagglutinin isolated from an edible legume, namely black bean, showed an anti proliferative activity(8) against tumor cell lines MG-63(8) and HepG2(8) but not the normal cell line.

Malignant osteocarcinoma cell treated with the phytochemical also exerted a significant effect in shrinking of tumor cells as well as inducing apoptosis.

The study also stated that hemagglutinin also induced cell death through interfering the first stage of tumor cell division in expression of protein, RNA, and DNA and inducing mitochondrial membrane depolarization(8) in controlling plasma membrane of a muscle or nerve cell

Furthermore, the study also suggested that the efficacy of hemagglutinin in causing cell death may be attributed to the function of protein in increased regulation of pro inflammatory expressions(8)

Dr. Dan X, the lead author said, " a novel hemagglutinin from an edible legume (showed) a growth-inhibitory effect on osteocarcinoma and liver cancer cells" and " The hemagglutinating activity of this hemagglutinin was demonstrated to be ion dependent and stable over a wide range of temperature and pH values".


4. Prostate Cancer
According to the National Taiwan University,fermentation products BN999, included black bean processed an anti prostate cancer effect through expression of prostate adenocarcinoma PC-3 cell line.

BN999, the product mixture induced cancer cell death by activating the protein gene involved pro cancer cell apoptosis via cell mediatory activities(9), including a network of membranous anatomical structure and double membrane-bound organelle in energy conversion.

Most importantly, BN999 target prostate and other cancer cell without affecting the normal human cells and inducing obvious side effects(9).

In the investigation of water-soluble black bean condensed tannins isolated from black beans showed a significant activity in induced cancer cell death by apoptosis without affecting the growth of normal cells, in dose dependent manner(10).

Additionally, the study also addressed that the efficacy of water-soluble in induced prostate cancer cell death may be attributed to direct effect in decrease cancer cell energy molecule and formation of cell structure.

Dr. Bawadi HA(10), the lead author indicated, after 24 h of injection, water-soluble black bean condensed tannins showed a strong reduced coagulation of blood in stimulated cancer cell migration and regulated mechanisms involved growth of prostate cancer in formation of new blood vessels.

5. Colon Cancer
Colon cancer is a medical condition of the abnormal proliferation of cells in large intestine.

In a study of rats injected with azoxymethane (AOM)-induced colon cancer or saline and one week later administered an AIN, black bean (BB) and soy flour (SF)--based diet, researchers found that mice fed with black bean showed a significant expression in attenuated gene expression in coloncarcinogenesis by modulating cellular kinetics and reducing inflammation(11).

Others experiment to test the prevalence of high bean intake and low incidence of colon cancer in many Latin American countries in 53-wk-old weanling male F344 rats randomly assigned by weight to the following groups: control (11 rats), casein diet (21 rats), and bean diet (21 rats), with animals fed the casein and bean diets treated with the carcinogen azoxymethane (AOM) once weekly for 2 wk, the results returned showed a significantly fewer colon adenocarcinomas (P < 0.05) in rat fed with bean diet in compared control and rats fed the casein diet(12).

Rats fed with bean diet also expressed a lesser in tumor multiplication observed by tumors per tumor-bearing rat than in casein-fed rats.

Dt. Hughes JS, the lead researcher said, "dry beans contain anticarcinogenic compounds capable of inhibiting AOM-induced colon cancer in rats. However, the specific anticarcinogenic components within dry beans have not been identified".

But suggested that the efficacy of bean in reduced colon cancer risk may be results of the dietary fiber, phytochemicals or other components within dry beans(12),...

Promisingly, the results of rats fed a modified AIN-93G diet (control) or diets containing 75% black beans or 75% navy beans for 4 wk, and then colon cancer initiated by administration of two injections of azoxymethane 1 wk apart, also postulated a lower incidence of colon cancer in rats fed the black bean (9%) in compared navy bean (14%) diets than in rats fed the control diet (36%) at 31 weeks(13).

Rats fed the black bean also significantly lower of total tumor multiplicity in compared to control(13).

The findings suggested that black bean with abundant bioactive chemical compounds such as genistein, flavonols and saponins.may be considered as functional food and integrated form of injection for reduced risk and treatment of various types of malignant tumors. However, raw black beans containing phytohenagglutinin can be toxic to liver in high amount(14).

Sources

(1) Common Beans and Their Non-Digestible Fraction: Cancer Inhibitory Activity—An Overview by Rocio Campos-Vega,1,* B Dave Oomah,2,† Guadalupe Loarca-Piña,1,† and Haydé Azeneth Vergara-Castañeda3(PMC)

(2) Fermentation product of soybean, black bean, and green bean mixture induces apoptosis in a wide variety of cancer cells by Chia JS1, Du JL, Wu MS, Hsu WB, Chiang CP, Sun A, Lu JJ, Wang WB.(PubMed)

(3) Phytochemicals of black bean seed coats: isolation, structure elucidation, and their antiproliferative and antioxidative activities by Dong M1, He X, Liu RH.(PubMed)
(4) Dietary dry bean effects on hepatic expression of stress and toxicity-related genes in rats by Daniell EL1, Ryan EP, Brick MA, Thompson HJ.(PubMed)

(5) Inhibition of Caco-2 colon, MCF-7 and Hs578T breast, and DU 145 prostatic cancer cell proliferation by water-soluble black bean condensed tannins by Bawadi HA1, Bansode RR, Trappey A 2nd, Truax RE, Losso JN.(PubMed)
(6) Fermentation product of soybean, black bean, and green bean mixture induces apoptosis in a wide variety of cancer cells by Chia JS1, Du JL, Wu MS, Hsu WB, Chiang CP, Sun A, Lu JJ, Wang WB.(PubMed)
(7) Phytochemicals of black bean seed coats: isolation, structure elucidation, and their antiproliferative and antioxidative activities by Dong M1, He X, Liu RH.(PubMed)

(8) Purification and Characterization of a Novel Hemagglutinin with Inhibitory Activity toward Osteocarcinoma Cells from Northeast China Black Beans by Dan X1, Wong JH1, Fang EF2, Chan FC3, Ng TB1(PubMed).

(9) Fermentation product of soybean, black bean, and green bean mixture induces apoptosis in a wide variety of cancer cells by Chia JS1, Du JL, Wu MS, Hsu WB, Chiang CP, Sun A, Lu JJ, Wang WB.(PubMed)
(10) Dietary patterns and prostate cancer risk in the National Health and Nutrition Examination Survey Epidemiological Follow-up Study cohort by Tseng M1, Breslow RA, DeVellis RF, Ziegler RG.(PubMed)

(11) Microarray Analyses of Genes Differentially Expressed by Diet (Black Beans and Soy Flour) during Azoxymethane-Induced Colon Carcinogenesis in Rats by Rondini EA1, Bennink MR.(PubMed)
(12) Dry beans inhibit azoxymethane-induced colon carcinogenesis in F344 rats by Hughes JS1, Ganthavorn C, Wilson-Sanders S.(PubMed)
(13) Consumption of black beans and navy beans (Phaseolus vulgaris) reduced azoxymethane-induced colon cancer in rats by Hangen L1, Bennink MR.(PubMed)

(14) Spleen and thymus histology and proliferative response of splenic cells in rats fed raw and cooked Phaseolus vulgaris beans by Toro F1, Benshimol AL, González Elorriaga M, Soyano A.(PubMed)

Herbal Therapy: Green Tea in Reduced Risk of Gut Microbiota Imbalance in Induction of Obesity and Gastrointestinal Diseases

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in improved microbiota  imbalance in Induction of obesity and gastrointestinal diseases, some scientists suggested.

Green tea, is a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Gut microbiota are microorganisms that lived in the digestive tracts in humans and animals.

According to the evaluation of obesity induced of C57BL/6 J male mice by feeding a high fat (HF) diet for 8 weeks, followed by treatment with oral tea saponin (0.5%) mixed in HF diet for a further 6 weeks, injection of tea saponin (0.5%) mice demonstrated a impressive activity in ameliorated endotoxemia which cause by accumulation of endotoxins in the blood, an indication of over production of gram-negative rod-shaped bacteria, reduced numbers of pro-inflammatory macrophage accumulation in the colon in exhibited colon inflammation and gut microbiota alterations in reduced expression of good bacteria, such as Bifidobacteria, Lactobacillus,... and over expression of harmful bacteria Escherichia Coli and Enterobacter caused by HF diet.

Patients with digestive disorders have been found to associate to imbalance of gut microbiota and dysbiosis of the gut bacteria communities that can lead to many chronic issues and diseases, including irritable bowel syndrome (IBS), coeliac disease, inflammatory bowel disease, obesity, colon cancer, and autism......, 

In fact, balancing of gut microbiota plays an important role in the harvest, storage, and expenditure of energy obtained from the diet and dysfunction of the community is associated  various causes in induction of obesity and malnutrition.

According to the study, teasaponin also improved glucose tolerance and reduced body weight gain in HF diet-induced obese mice that may be an expression of green tea extract in limit unfavorable gut microbiota alterations in HF diet-induced obesity.

Additional analysis of orally administration of three types of tea infusions for 13 weeks in high-fat-diet induced obese C57BL/6J mice to examine their anti-obesity and gut microbiota modulatory effects.suggested that application of the tea infusion showed strong effect in the prevention of the development of obesity with no significant differences and expressed a substantially increased diversity and altered the structure of gut microbiota in tested mice.

According to the high-throughput MiSeq sequencing, multivariate statistical and linear discriminant assays, Dr. iu Z, the lead author at the Fuzhou University said, "tea infusion consumption substantially increased diversity and altered the structure of gut microbiota" and "(Some) key phylotypes (such as Alistipes, Rikenella, Lachnospiraceae, Akkermansia, Bacteroides,...) might have a close association with the obesity related indexes of the host".

Interestingly, in male Swiss albino mice were fed with HFD (58% fat kcal) induced alterations of gut microbiota for 12 weeks, green tea extract (GTE) and isomalto-oligosaccharide (IMOs), a naturally occurring plant-based dietary injection, significantly improved liver metabolome associated with lipid metabolism and prevented imbalance of gut microbiota in damage of the lining of the small intestine (leaky gut), through reduced expression of lipopolysaccharides(LPS) in the blood stream(an indication of serve inflammation) and pro-inflammatory cytokines (e.g. resistin, TNF-α, and IL-1β).

Dr. Singh DP, the lead scientist at the University Institute of Pharmaceutical Sciences (UIPS) after differentiating above illustration said, " Combination (of GTE and IMOs restores the balance of gut microbiota through), improved beneficial gut microbiota (Lactobacillus sp., Bifidobacteria, Akkermansia muciniphila, Roseburia spp.) abundances, restored Firmicutes/Bacteriodetes and improved Prevotella/Bacteroides proportions".

Taking altogether, green tea and its phytochemical constituents expressed strongly improved beneficial effects on multiple parameters in maintaining the favorable gut microbiota ratio in reduced risk of the onset of certain diseases, including obesity, celiac disease, inflammatory bowel disease.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Dietary teasaponin ameliorates alteration of gut microbiota and cognitive decline in diet-induced obese mice by Wang S1,2, Huang XF3,4, Zhang P1,5, Newell KA1, Wang H1, Zheng K5, Yu Y6,7.(PubMed)
(2) The modulatory effect of infusions of green tea, oolong tea, and black tea on gut microbiota in high-fat-induced obese mice by Liu Z1, Chen Z1, Guo H1, He D1, Zhao H1, Wang Z1, Zhang W1, Liao L1, Zhang C1, Ni L1.(PubMed)
(3) Isomalto-oligosaccharides, a prebiotic, functionally augment green tea effects against high fat diet-induced metabolic alterations via preventing gut dysbacteriosis in mice by Singh DP1, Singh J2, Boparai RK3, Zhu J4, Mantri S2, Khare P1, Khardori R5, Kondepudi KK6, Chopra K7, Bishnoi M8.(PubMed)

Food Therapy: Eggplant and Its Bioactive Gallic Acid and Anthocyanins In Ameliorated Risk and Treatment of Fibrosarcoma

Kyle J. Norton 

Eggplant may have a potential and substantial effect in reduced risk and treatment of colon cancer, some scientists suggested.

Eggplant is a species of S. melongena with deeply purple color, belongings to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.

Fibrosarcoma is medical condition characterized by irregular cell growth in the issues of fibrous connective tissue. The tumor can be classified into low grade, intermediate malignancy and high malignancy, depending to different degrees of differentiation:

In the investigation of eggplant (Solanum melongena var. marunasu) extract activity on human fibrosarcoma HT-1080 cell lines, researchers at the Gifu Pharmaceutical University found that delphinidin, a flavonoid pigment containing in the peel, did not affect tumor cell cells interact and attach to a surface, substrate or another cell to the basement membrane matrix Matrigel (MG) to initiate the tumor cells proliferation or migration, but modulated the expression of  matrix metalloproteinase(MMP)-2 and MMP-9 secreted by the tumor cell, thus reducing risk of the matrices in stimulated cancer cell growth and tumor expansion. 

In vivo, the basement membrane matrix Matrigel (MG) has been used to measure the angiogenic inhibitors and stimulators, repair damaged tissues, and increase tumor growth in some cancer experiments.

Further differentiation of delphinidin in cancer risk insisted that the chemical constituents also inhibited cancer cell invasion through reduced expression of inhibited serum- and vascular endothelium growth factor in induction of making new blood vessel to provide nutrients and oxygen for proliferation and cancer progression.

Moreover, researchers also indicated that the efficacy of anti cancer cell activity of delphinidin was attributed to the function of phytochemical in triggering extracellular signal–regulated kinases (ERKs) in regulated cancer cell cycle division, including meiosis, mitosis, and post mitosis.

In depth analysis also discovered that delphinidin isolated from eggplant also activated the independent of nitric oxide pathway in suppression of cancer cell progression by initiated cell cycle arrest. in the G(0)/G(1) phase.

Interestingly, Gallic acid and anthocyanins the bioactive chemical constituents isolated from eggplant and other fruits and vegetables in the study of human fibrosarcoma HT-1080 suggested that injection of gallic acid and anthocyanins derivative delphinidin-3-glucoside demonstrated a significant activity in induction of cell apoptosis through cytotoxicity.

According to the . Zymographic analysis, gallic acid exerted the anti cancer cell growth and tumor invasiveness through inhibited the secretion and activation of gelatinase proteases which has the same function in activated cancer progression and metastasis by the tumor.

Importantly, gallic acide also ameliorated cancer progression through inhibition of the matrix metalloproteinase(MMP)-2 and MMP-9 same as the effectiveness as delphinidin involved in anti angiogenestic activity.

Taken together, eggplant with abundant bioactive chemical compounds such as gallic acid and anthocyanins may be used as functional food for reduced risk and treatment of  fibrosarcoma, depending to further investigation.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Inhibitory effect of delphinidin from Solanum melongena on human fibrosarcomaHT-1080 invasiveness in vitro by Nagase H1, Sasaki K, Kito H, Haga A, Sato T.(PubMed)
(2) Delphinidin inhibits endothelial cell proliferation and cell cycle progression through a transient activation of ERK-1/-2 by Martin S1, Favot L, Matz R, Lugnier C, Andriantsitohaina R.(PubMed)
(3) Dietary gallic acid and anthocyanin cytotoxicity on human fibrosarcoma HT1080 cells. A study on the mode of action by Filipiak K1, Hidalgo M, Silvan JM, Fabre B, Carbajo RJ, Pineda-Lucena A, Ramos A, de Pascual-Teresa B, de Pascual-Teresa S.(PubMed)