Food Therapy: Lentils Intake in Attenuated Risk and Progression of Atherosclerosis

Kyle J. Norton

Lentil intake may have a potential effect in reduced risk, progression and treatment of atherosclerosis, some scientists proposed.

Lentil, a type of pulse and tiny legumes that can be cooked quickly and rich in protein and fiber, is a bushy annual plant of genus Lens to the Fabaceaefamily, native to Middle East.

Atherosclerosis is a medical condition of plaque accumulated in the inner part of the arteries, leading to reduce levels of oxygen-rich and nurients blood to your heart and other parts of your body.

According to statistic, 13.8% of adults of 20 years and above were diagnosed with atherosclerosis in 2010 with motility rate of 32%, approximately.

In the study to examine a hydroalcoholic extract isolated from lentils activity in induction of hypocholesterolemic action and the potential prebiotic effect through evaluating the concentration of bile acids in the feces in an animal model, after 71 days of diet-induced hypercholesterolemia in rats, researchers found that application of lentil extract (LE) displays a significantly reduced cholesterol level by 16.8% and increased secretion of the level of bile acids in the feces of rats by induced production of prebiotic to selective stimulation of growth of  limited numbers of micro-bacteria  in the gut microbiota.

The improvement of lentil extract (LE) in lowering levels of cholesterol probably was attributed to prebiotic action induced by the extract in mediated α-glucans metabolism in probiotic bacteria in reduced serum cholesterol levels and β-glucans in enhanced good gut bacteria and reduced bad cholesterol accumulation.

There is a report suggested that intake oat fiber β-glucan levels of least 3 g per day can significant decrease the levels of saturated fats in the blood which has been found to contribute to substantial risk of heart disease.

Further observation also indicated that lentil extract (LE) increases function of digestive tract in decreased cholesterol absorption which can be viewed by examining greater bile acid presence in the animal feces.

After taking into account of other con founders, Dr. Micioni Di Bonaventura MV, the lead scientist postulated, "This new hydroalcoholic extract obtained from lentils was shown to possess hypocholesterolemic and prebiotic properties, and could have interesting applications in the field of nutraceuticals".

Additionally, in the testing of potential of high-Se lentils effect cultivated from the Canadian prairies as a therapeutic food to alter the outcome of arsenic (As)-enhanced atherosclerosis in male ApoE(-/-) mice exposed to a moderate level of As (200ppb) in their drinking water, and control mice on tap water received one of three lentil diets: Se-deficient (0.009mg/kg), Se-adequate (0.16mg/kg) or Se-high (0.3mg/kg), after 13 weeks, researchers indicated that mice group treated with moderate level of As demonstrated a elevated levels of plaque formatiom, accumulated in the aortic arch and sinus, in compared to a completely eliminated levels of As in the aortic arch of mice treated with Se-high lentil diet, but increased in As-exposed mice and on both the Se-deficient and Se-adequate diets.

Notably, observation of the ratio of high-density lipoprotein/low-density lipoprotein also indicated that selenium plays an important role in proatherogenic composition of serum lipids as the cholesterol levels were seen to increase in As-exposed mice and on both the Se-deficient and Se-adequate diets.

Moreover, mice groups exposured to As in both Se-deficient and Se-adequate diets also expressed significant levels of oxidative stress caused by over expression of reactive oxygen species (ROS) and decreased levels of antioxidant in compared to Se fortified diet mice group, measured by intralesional cellular composition and hepatic oxidative stress assays.

Indeed, adding High-Se lentils diet into human populations living in countries with As contamination of drinking water may be one of good application in protection against As-triggered atherosclerosis.

Taking altogether, intake of lentils with or without selenium fortification may be considered as a whole food therapeutic treatment in attenuated risk and progression of atherosclerosis, particularly, in high risk adults.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Source
(1) Evaluation of the hypocholesterolemic effect and prebiotic activity of a lentil (Lens culinaris Medik) extract by Micioni Di Bonaventura MV1, Cecchini C2,3, Vila-Donat P4, Caprioli G4, Cifani C1, Coman MM2,3, Cresci A2,3, Fiorini D5, Ricciutelli M4, Silvi S2,3, Vittori S4, Sagratini G4.(PubMed)
(2) High-selenium lentil diet protects against arsenic-induced atherosclerosis in a mouse model by Krohn RM1, Lemaire M2, Negro Silva LF3, Lemarié C4, Bolt A2, Mann KK2, Smits JE5.(PubMed)

Food therapy: Lentils Intake in Weight Loss and Complications and Treatment of Obesity

By Kyle J. Norton

In take of lentils' pulses daily and regularly may have a substantial and profound effect in reduced risk and treatment of obesity, some scientists postulated.

Lentil, a type of pulse and tiny legumes that can be cooked quickly and rich in protein and fiber, is a bushy annual plant of genus Lens of the Fabaceae family, native to Middle East.

Obesity is a medical condition of excess body fat accumulated overtime. According to the Body Mass Index(BMI), BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

The investigation of lentils' pulses in risk of obesity has been found to associate to several mechanisms involving numbers of aspects.

In the review of  medical literature published online of databases MEDLINE, Embase, CINAHL, and the Cochrane Library through 11 May 2015 for randomized controlled trials of ≥3 wk of duration, met the criteria and guideline, researchers indicated that out of 21 trial including 940 participants selected, intake of pulse has a significant effect in reduced mean of weight loss of .34 kg during 6 weeks of application in compared to control diet without adding dietary pulse.

Further analysis, also suggested that the weight reduction was also correlated to the effect of dietary pulse implication in decreased energy intake as well as exhibited progression in weigh maintenance in tested subjects.

Particularly,  the percentage fat concentration of pulse injection attendees also wss found to reduce substantially in compared to control with no restriction to calories intake.

Additional comparison of the effect of dietary pulses (beans, peas, chickpeas, lentils) on acute satiety and second meal intake with isocaloric diets, in a systematic review and meta-analysis from data extracted from MEDLINE, EMBASE, CINAHL, and the Cochrane Registry (through May 6, 2013) conducted by the University of Toronto, showed that dietary pulses produce a 31% greater satiety incremental area under the curve (IAUC), according to ratio of means (RoMs) without affecting second meal intake in compared to a moderate-carbohydrate, moderate-fat diet.

The greater satiety in pulse intake may form a base in improved dietary habit in the United States to include more consumption of dry beans, peas and lentils, rich sources of nutrients and phytochemicals.

The US Department of Agriculture's (New) recently recommended that MyPyramid guidelines should have a doubling dietary intake for vegetables, particularly, in subgroups of vegetables, including dry beans, peas and lentils.

Further differentiation of the pulse intake in obese subjected also indicated that adding a portion of lentils into daily diet may have a potential effect in reduced  the incidence of obesity and diabetes through phenolic-rich lentils inversely associate to increased blood glucose and lipid accumulation.

And intake of pulse frequently also may lend a sustainable effect in reduced food intake and waist conference and induced weight loss through the expression of antinutrients and energy regulation activities.

More importantly, with low GI range from ∼29 to 48 (using glucose as the standard), pulse carbohydrates are slowly digested due to the presence of several constituents, including carbohydrate composition, protein content and protein-starch matrix, and antinutrient factors such as enzyme inhibitors in compared to other healthy food with GI of 32–36 for dairy, 39–64 for fruit, 42–72 for grains, 49–80 for breakfast cereals, and 49–97 for root vegetables.

According some studies, examining the potential associations between pulse consumption and weight status consistently show that individuals with lower BMI consume a greater amount of pulses as part of their usual diet and pulse diet expressed an inverse association of the dietary pattern incorporating pulses with BMI or BMI increase over time.

Taking altogether, there is no doubt that intake of lentils daily and regularly have a potential and therapeutic effect in reduced risk and treatment of obesity, particularly in decreased risk of obese incidences of complication.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Effects of dietary pulse consumption on body weight: a systematic review and meta-analysis of randomized controlled trials by Kim SJ1, de Souza RJ2, Choo VL1, Ha V3, Cozma AI4, Chiavaroli L1, Mirrahimi A5, Blanco Mejia S1, Di Buono M6, Bernstein AM7, Leiter LA8, Kris-Etherton PM9, Vuksan V8, Beyene J10, Kendall CW11, Jenkins DJ8, Sievenpiper JL12.(PubMed)
(2) Dietary pulses, satiety and food intake: a systematic review and meta-analysis of acute feeding trials by Li SS1, Kendall CW, de Souza RJ, Jayalath VH, Cozma AI, Ha V, Mirrahimi A, Chiavaroli L, Augustin LS, Blanco Mejia S, Leiter LA, Beyene J, Jenkins DJ, Sievenpiper JL.(PubMed)
(3) Polyphenol-Rich Lentils and Their Health Promoting Effects by Kumar Ganesan ID and Baojun Xu (Internation Journal of molecule science)

Alternative Therapy: Yoga Practice in treatment of Illicit Substance Abuse

Kyle J. Norton

Epidemiological studies strongly suggested that yoga intervention may have positive and therapeutic effects for treatment of illicit substance abuse.

Yoga, the ancient practical technique for harmonized external and internal body well beings, through breath control, meditation, bodily movement and gesture..... has been best known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

The review of literature published online of database from January 1980 to January 2009 to evaluate the effects of yoga in patients with addictive disorders, based on the standard criteria and guidelines, suggested that yoga intervention exhibited some differential improvement across conditions which were maintained during follow-up, including psychiatric symptoms, particularly in the level of perceived stress, as well as improved mental state of substance abusers to accept unusual physical sensations, thus reducing from a strong urge and act impulsively.

In deed, the reduced temptation and  impulsive act of substance abusers to reach for illicit substance can be attributed to yoga relaxation and meditation intervention in induced harmonization of the body and mind in feelings of peace and comfort to deal with increased addictive temptation and to cop and tolerate the uncomfortable feelings and physical sensations that can lead to relapse.

Some researchers suggested that the developing positive relationship with physical sensation is one of the reason to facilitate the calmness and relaxation in bringing one's attention to experiences occurring in the present moment, while letting go of them or deal them in a positive way, thus reducing the urge for sedatives, pain relievers, amphetamines, and alcohol.

In the aspect of hormonal imbalance caused by stress induced  anxiety disorders, depression, and posttraumatic stress disorder and substance abuse, yoga intervention expressed a significant effect in reduced stress through mediation and relaxation by calming the mind and body through reduced tension of CNS. Without influence of stress, hormone balancing was automatically restored, particularly in secretion of stress hormones cortisol and adrenaline.

More importantly, by bring the yoga participants into a relaxed state, yoga intervention improved the  mind in react to presence and focus on deal the compulsion in the right way to prevent relapsing.

Dr. Skanavi S, the led author said, " Practice of mindfulness may develop the ability to maintain perspective in response to strong emotional states and mood fluctuations and increase the saliency of natural reinforcers. Mindfulness based programs require an intensive participation, and should therefore be proposed to highly motivated patients".

Not surprisingly, in the testing of the general belief that the efficacy of incorporating mindfulness practices into the treatment of addiction, Dr, Witkiewitz K, the led authors conducted a review of theoretical models of mindfulness in the treatment of addiction and several hypothesized mechanisms of change and found that yoga mindfulness addresss a relapse prevention (MBRP), including session content, treatment targets, and client feedback may be considered as a secondary therapeutic exercise in combined with standart treatment in treating illicit substance abuse patients.

According to the Kasturba Medical College, Manipal University in reviews the philosophical origins, current scientific evidence, and clinical promise of yoga and mindfulness as complementary therapies for addiction, yoga mindfulness improved the well being of the skills, insights, and self-awareness may be used in target multiple psychological, neural, physiological, and behavioral processes implicated in addiction and relapse.

Truly, yoga mindfulness enhanced the relaxation of calmness state to improve participant desire to control the circumstances while building physical strength, endurance, and psychological awareness in time of stress and sadness...... to face the presence directly in a new way. 

Furthermore, the study also indicated that the above treatment have been proven in some well-designed clinical trials and experimental laboratory studies on smoking, alcohol dependence, and illicit substance use, but preventing addiction was lack.

Dr. Khanna S, the led author said, " ....better understand what types of yoga and mindfulness-based interventions work best for what types of addiction, what types of patients, and under what conditions".

Based on the information in analysis, the study also emphasized that yoga mindfulness may be used as integrated form of intervention to reduced both psychological and physical aspects in patients with illicit substance abuse, especially in reduced the impulsive urge of temptation.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years

Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) [Mindfulness based interventions for addictive disorders: a review].[Article in French] by Skanavi S1, Laqueille X, Aubin HJ.(PubMed)
(2) Mindfulness-based treatment to prevent addictive behavior relapse: theoretical models and hypothesized mechanisms of change by Witkiewitz K1, Bowen S, Harrop EN, Douglas H, Enkema M, Sedgwick C.(PubMed)
(3) A narrative review of yoga and mindfulness as complementary therapies for addiction by Khanna S1, Greeson JM.(PubMed)

Food Therapy: Lentils and Whole Food Lectin, A Treatment and Biomarker and Therapeutic Targets for treatment of Cervical cancer

Kyle J. Norton

 Protein binding lectin (including lectin isolated from lentils) may have a positive and profound effect for treatment of cancers and used as a new type of potential biomarkers and therapeutic targets in treatment of cervical cancer, some scientists suggested.

Lentil a type of pulse and tiny legumes that can be cooked quickly and rich in protein and fiber is a bushy annual plant of genus Lens in the Fabaceae family, native to Middle East.

Lectins are carbohydrate-binding proteins with function to specifically interact with other carbohydrate moieties.

The investigation of the effect of protein binding lectin for treatment of cancers and as potential biomarkers and therapeutic targets in treatment of cervical cancer, was depending to expression of certain mechanisms in some aspects.

In the study of the effect of Frutalin, α-D-galactose-binding lectin, isolated from Pichia pastoris and native frutalin on cervical cancer cell line HeLa measured by confocal microscopy, researchers found that Frutalin expressed a significant magnitude in induction of cytotoxicity on cell growth and cell apoptosis in tested HeLa cell line through targeting HeLa cell's nucleus. 

Additionally, in other study to evaluate the association of specific mbl-2 alleles(mannose-binding lectin (MBL)) and susceptibility to HPV infection of 150 patients with HPV and 277 control subjects with no HPV, scientists suggested that there is potential linking of expression of mannose-binding lectin (MBL) in high risk HPV in induction of cervical cancer, but patients with the mbl-2 alternative phenotypes gene represented a least significant risk for the group with HPV, even though, the frequency of high-producer mbl-2 genotypes  was found higher in patients with HPV than in control.

Mannose-binding lectin (MBL), is a serum lectin with function in signalling innate immunity in mediated phagocytosis via the lectin pathway.

Further more, the study to find a new type of potential biomarkers and therapeutic targets for treatment of cervical cancer by evaluating Galectin-1, -3 and -9, the proteins bind β-galactoside sugars via lectin pathway indicated that galectin expression was found to associate to tumor cells, tumor epithelium infiltrating immune cells and stromal cells in squamous cervical cancer.

Indeed, tested tumor cells, fibroblasts, macrophages and T cells all expressed the presence of galectins in different scores.

Galectin-1 and -9 were both expressed by tumor cells in 11% of samples, while 84% expressed galectin-3.

Moreover, the Strong galectin-1 expression by tumor cells as an independent predictor was found to associate to poor survival and correlated with increased tumor invasion in compared to weak and positive tumor cell galectin-3 expression in correlated with increased and decreased tumor invasion and tumor cell expression of galectin-9 showed a trend toward improved survival.

In depht evaluation also found that tumor CD163+ macrophages associated to progression and prognostication of cervical cancers was predominant immune cell type found to expressing galectin-1, -3 and -9. More precisely, Galectin-1 and -3 were expressed by a minor population of T cells and Galectin-1 was mainly expressed by fibroblasts in the tumor stroma.

After taking into account of other con founder, researchers concluded that Galectin-1 expression might be used as a marker to target more aggressive anti-cervical cancer treatment.

Taken together, protein binding lectins may have a potential effect in induction of cells apoptosis and proliferation on cervical cancer

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Galectin-1, -3 and -9 Expression and Clinical Significance in Squamous Cervical Cancer by Punt S1, Thijssen VL2, Vrolijk J3, de Kroon CD4, Gorter A1, Jordanova ES5.(PubMed)
(2) Mannose-binding lectin in high-risk human papillomavirus infection by Tsai CC1, Lin TM, You HL, Eng HL.(PubMed)
(3) Cytotoxic Effects of Native and Recombinant Frutalin, a Plant Galactose-Binding Lectin, on HeLa Cervical Cancer Cells by Carla Oliveira, Ana Nicolau, José A. Teixeira, and Lucília Domingues(PMC)

Herbal Therapy: Green Tea and Green Tea Epigallocatechin Gallate (EGCG) In Protection and Treatment of Retinal Degenerative Disease

Kyle J. Norton

Green tea phenolic content may have a sustainable and therapeutic effect in reduced risk and progression of retinal degeneration, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Retinal degeneration is a macular disease characterized by impaired vision, night blindness, retinal detachment, light sensitivity, tunnel vision, and loss of peripheral vision to total loss of vision.

The evaluation of green tea effect in risk of retinal degeneration was found to be implicated by several mechanisms through numbers of aspects.

In ROS implication of oxidative stress-induced degeneration of the retina occurred in age-related macular degeneration (AMD) and glaucoma, application of green tea polyphenols epigallocatechin gallate (EGCG) exhibited antioxidant effect as free radical scavenger in ameliorated chain reaction of ROS in causing loss of neuron with direct effects of retinal function and reduced cytotoxicy of free radicals in induction of retinal cellular apoptosis.

Administration of green tea phynolic compound exerted 10 times more effective in treatment of retinal degeneration, in compared to potent medicine trolox (vitamin E analogue) in attenuating lipid peroxidation caused by the nitric oxide donor, sodium nitroprusside (SNP), according to the study.

Particularly, green tea epigallocatechin gallate (EGCG) inhibited a significant decrease in photoreceptor-specific markers (RET-P1, rhodopsin kinase) which may be an indication of photoreceptor cells in the transition to degenerate prematurely, eventually resulting in blindness and an increase in the cell death marker caspase-3 caused by oxidative stress induced by injection of sodium nitroprusside (SNP)

According to the observation by Western blotting techniques, SNP was completely inhibited by EGCG injection in ameliorated the detrimental effects to the retina caused by SNP. 

Dr. Zhang B, the co-author said, "Since oxidative stress has been implicated in retinal diseases like AMD and glaucoma this study provides "proof of principle" for the idea that daily intake of EGCG may help individuals suffering from retinal diseases where oxidative stress is implicated".

More interestingly, in BALB/cJ mice treated with either EGCG or saline via intraperitoneal (IP) injection, and then placed under constant cool white light-emitting diode (LED) light (10,000 lux) for 5 h, EGCG treatment group showed a strong protective effect on the retina against light damage (LD) in compared to the control group.

According to the optical coherence tomography (OCT) and and electroretinography (ERG),  in the examine the retinal structure and function after LD indicated that application of green tea EGCG improved significantly higher ERG amplitudes for all three wave types through inducing morphologic protection of photoreceptors also in compared to control.

Moreover, the green tea extract bio-compound also decreased oxidative stress through increase the mRNA level of the antioxidant expression of Sod2, a manganese-dependent superoxide dismutase (MnSOD) before LD and 24 h after LD.

Dr. Qi S1,, the lead author said, "The IP injection of EGCG attenuated the detrimental effects of bright light on the retinas of BALB/cJ mice by protecting the structure and function of the retina".

Importantly, in study to evaluate green tea EGCG effect in reduced  glutamate  induced excitotoxicity in the retina, researchers conducted a study of female Wistar rats (n = 171) randomly signed into a normal control group (n = 9); saline control group with intravitreal saline injections (n = 54); NMDA control group with an intravitreal NMDA injection and intraperitoneal saline injections (n = 54); and NMDA study group (n = 54) receiving an intravitreal NMDA injection plus intraperitoneal EGCG (25 mg/kg) injections, observation of the groups at 2 weeks after additional injection of NMDA showed that group with treatment of intraperitoneal application of EGCG reduced a significantly less marked NMDA-associated loss of retinal ganglion cell, through inhibition of decreasing retinal ganglion cell layer (GCL), neurons located near the inner surface (the ganglion cell layer) of the retina of the eye in received visual information from photoreceptors via cell density and thickness of Thy-1 immunoreactivity in several areas of the immature and adult human brain in expression of retinal ganglion cell damage.

Taken together, there is no doubt that Epigallocatechin-3-gallate (EGCG), a major polyphenol of green tea, may be considered as secondary therapeutic treatment used combination with standard therapy for protection and treatment of retinal degenerative disease 

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299

Sources

(1) Oxidative-induced retinal degeneration is attenuated by epigallocatechin gallate by Zhang B1, Osborne NN(PubMed)
(2) Neuroprotective effect of epigallocatechin-3-gallate against N-methyl-D-aspartate-induced excitotoxicity in the adult rat retina by Chen F1, Jiang L, Shen C, Wan H, Xu L, Wang N, Jonas JB(PubMed)

(3) Intraperitoneal injection of (-)-Epigallocatechin-3-gallate protects against light-induced photoreceptor degeneration in the mouse retina by Qi S1,2, Wang C1,2, Song D2, Song Y2, Dunaief JL2.(PubMed)--

Herbal Therapy: Green Tea and Green Tea Catechins In reduced Risk and Treatment of Pancreatic Cancer

Kyle J. Norton

Green tea may have a therapeutic and positive effect in reduced risk and treatment of pancreatic cancer, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Pancreatic cancer is medical condition characterized by irregular cell growth in the issues of pancreas. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.

According to statistic, the average lifetime risk of pancreatic cancer for both men and women is about 1 in 65.

In the analysis of medical literature published online, green tea catechins,  epigallocatechin gallate (EGCG) effect in reduced risk and treatment of pancreatic cancer was attributed to the contributions of various mechanisms.

In human pancreatic ductal adenocarcinoma (PDAC) cell lines PancTu-I, Panc1, Panc89 and BxPC3, to compare the inhibited effect of EGCG to 2 components of catechins, namely, catechin gallate (CG) and epicatechin gallate (ECG), application of green tea 2 catechins components demonstrated a strong effect in inhibited proliferation of PDAC cells in a dose- and time-dependent manner.
In comparison test, green tea CG and ECG exerted much stronger anti-proliferation effects than those of EGCG.

The proliferation of PancTu-I cells retained by green tea catechin was attributed to the antioxidant effect in interference of the cancer cell division cycle through mediating the cytokines in modulation of cell cycle regulatory proteins, such as cyclins, a cell division regulators, cyclin-dependent kinase (Cdk) enzymes activated by cyclins in regulated cell progression through cell cycle arrest, and CDK inhibitors with function in prevented over proliferation of cancer cells.

Additionally, all 3 components of green tea catechins also demonstrated a substantiated effect in ameliorated secretion of pro-inflammatory and invasion promoting proteins of the cancer cell through expression of TNF tumor necrosis factor in activated of the nuclear factor NF-κB protein signalling involved mediation of DNA transcript, pro inflammatory cytokines production and cancer cell survival.

Tumor necrosis factor is a cell signaling protein possessed a wide range of proinflammatory actions

NF-κB is a protein with function in controlled transcription of DNA, cytokine production and cell survival.

Further analysis once again found that green tea catechins ECG and CG exhibit potent and much stronger anti-proliferate and anti-inflammatory activities on PDAC cells in compared to EGCG

In human pancreatic cancer cells lines MIA PaCa-2 cells, injection of green tea EGCG plus Bleomycin, (BLM), an anti-cancer chemotherapeutic drug displayed a substantial effect in inhibited cell proliferation through cell cycle transition phase arrest and mitochondrial depolarization by mitochondrial permeability transition in induction of cell apoptosis, after 72 hours.

Additional examination,  indicate that EGCG and BLM exhibited anti-proliferative effects significantly in induced apoptosis of MIA PaCa-2 cells and suggested that this combination could represent a new strategy with potential advantages for treatment of pancreatic cancer.

In pancreatic cancer cell lines MIA PaCa-2 and PANC-1, injection of pterostilbene isolated from blue berry and EGCG expressed a strongly additive antiproliferative effect after 72 hours with MIA underwent S-phase arrest but not in cancer cell line PANC-1.

Both pterostilbene and EGCG induced mitochondrial depolarization in enhanced cytochrome c released from mitochondria to trigger programmed cell death during the early stages of apoptosis was observed also in MIA, but not in PANC

EGCG increased caspase-3/7 function in induced cell apoptosis in MIA but the combined treatment did not significantly increase the activity in either cell lines. these contradictory activities may indicate that cell death occurs in MIA, possibly through another mechanism.

Taking altogether, green tea with abundant antioxidant catechins may be used as adjunct therapy for reduced risk and combined standard medicine for treatment of pancreatic cancer.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells. by Kürbitz C1, Heise D, Redmer T, Goumas F, Arlt A, Lemke J, Rimbach G, Kalthoff H, Trauzold A.(PubMed)
(2) Inhibitory effect of (-)-epigallocatechin-3-gallate and bleomycin on human pancreatic cancerMiaPaca-2 cell growth by Bimonte S#1, Leongito M#1, Barbieri A2, Del Vecchio V2, Barbieri M1, Albino V1, Piccirillo M1, Amore A1, Di Giacomo R1, Nasto A1, Granata V3, Petrillo A3, Arra C2, Izzo F1.(PubMed)
(3) Inhibitory effects of (-)-epigallocatechin-3-gallate and pterostilbene on pancreatic cancer growth in vitro by Kostin SF1, McDonald DE, McFadden DW.(PubMed)

Food Therapy: Lentils (Legumes) in Reduced Risk, Progression and Treatment of Metabolic Syndrome

Kyle J. Norton

Daily and regularly intake of lentils may have a potential and therapeutic effect in reduced risk and treatment of metabolic syndrome, some researchers suggested.

Lentil, a type of pulse and tiny legume that can be cooked quickly and rich in protein and fiber is a bushy annual plant of genus Lens pf the Fabaceae family, native to Middle East.

Metabolic syndrome is a set of conditions characterized by increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels which are considered as risk factors of cardiovascular disease and diabetes.

Investigation of lentils effect in risk of metabolic syndrome was depending to numbers of mechanism through several aspects.

The testing of low-GLoad foods effect in metabolic syndrome occurrence with 131 male Nile rats aged 3 weeks to 15 months randomly assigned to 15 dietary exposures of varied Glycemic Index (GI, 36-88), GLoad (102-305/2000 kcal), and cumulative GLoad (Cum GLoad=days×GLoad, 181-537g total glucose), indicated that lentil diets with low GLoads (102, 202) displayed a significant effect in reduced onset and treatment of metabolic syndrome in compared to other food with higher glycemic index.

More specifically, the benefit from lentils exceeded dietary factors of conbined macronutrient composition (%Energy from carbohydrate:fat:protein, between 70:10:20 to 40:40:20), total fiber (0-24%), or dietary caloric density (2.9-4.7 kcal/g) found in the legume.

Additionally, the experiment also found that lentil diet even reversed the progression in metabolic syndrome and diabetes expression in the tested Nile rats.

According to the randomized assays, intake of lentils over 15 dietary exposures decreased factors of insulin resistance, lower blood sugars, particular in fasting glucose levels as well as improving levels of blood lipid and ratio of cholesterol= high density choleaterol#/ total cholesterol#.

Inspection of total food intake of tested rat also demonstrated a strong correlation between the cumulative GLoad (Cum GLoad=days×GLoad, 181-537g total glucose) and parameters of MetS and T2DM.

In other word, longer term intake of lower Gload intake are correlated linearly to lesser prevalence risk of cardiovascular disease and diabetes.

More profoundly, according to the University of Toronto, in the experiment to investigate the effects of frequent consumption (five cups/week over 8 weeks) of pulses (yellow peas, chickpeas, navy beans and lentils), compared with counselling to reduce energy intake by 2093 kJ/d (500 kcal/d), on risk factors of the MetSyn of two groups (nineteen and twenty-one subjects, respectively) of overweight or obese (mean BMI 32·8 kg/m2) adults, measurement of body weight, waist circumference, blood pressure, fasting blood parameters and 24 h food intakes at weeks 1, 4 and 8 and blood glucose, insulin, C-peptide, glucagon-like peptide-1 (GLP-1) and ghrelin were measured after a 75 g oral glucose load at weeks 1 and 8 indicated that frequent consumption (five cups/week over 8 weeks) of pulses displayed a significant and positive effect in reduced energy intake in ubction of weight loss, waist circumference, systolic blood pressure, glycosylated Hb (HbA1c), and glucose AUC and homeostasis model of insulin resistance (HOMA-IR) following the glucose load (P < 0·05) similar to those in energy group.

Glycosylated Hb (HbA1c), a measurement of three-month average plasma glucose concentration is used  to determine risk of diabetes in suspected subject. There is an suggestion of lower HbA1c level by 1% associated to lower 19% risk of diabetes onset.

Homeostatic model is a test with an aim to assess the function of β-cell and insulin resistance (IR) from basal (fasting) glucose and insulin or C-peptide, a proinsulin molecule concentrations.

Further analysis also found that  frequent consumption (five cups/week over 8 weeks) of pulses (yellow peas, chickpeas, navy beans and lentils also increased HDL levels and fasting C-peptide and insulin Area under the curve (AUC) responses in compared to energy group. In deed, the influence of the above parameters was associated linearly and directly to types of diet intake..

More precisely, pulse treatment group showed HDL and C-peptide increased by 4·5 and 12·3 %, respectively, in compared to decreased by 0·8 and 7·6 %, respectively, in the energy-restricted group.

Insulin AUC decreased in both females and males on the energy-restricted diet by 24·2 and 4·8 %, respectively, but on the pulse diet it decreased by 13·9 % in females and increased by 27·3 % in males (P < 0·05).

Taken together, there is no doubt that frequent intake of lentils or legume products may have a substantial and direct influence in reduced risk, progression and treatment of metabolic syndrome.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Low glycemic load diets protect against metabolic syndrome and Type 2 diabetes mellitus in the male Nile rat by Bolsinger J1, Landstrom M2, Pronczuk A3, Auerbach A4, Hayes KC5.(PubMed)
(2) Regular consumption of pulses for 8 weeks reduces metabolic syndrome risk factors in overweight and obese adults by Mollard RC1, Luhovyy BL, Panahi S, Nunez M, Hanley A, Anderson GH.(PubMed)
(3) A legume-based hypocaloric diet reduces proinflammatory status and improves metabolic features in overweight/obese subjects by Hermsdorff HH1, Zulet MÁ, Abete I, Martínez JA(PubMed)