Food Therapy: Coffee< or = 3 Cups/day in Reduced Risk of Rheumatoid Arthritis (RA) Incidence

Kyle J. Norton, Master of Nutrients


Total coffee intake daily is associated to non risk factor but attenuated risk of incidence of rheumatoid arthritis, the  joint study by the Harvard Medical School and Brigham and Women's Hospital, Boston and a Asian study, suggested, respectively.

Coffee,  a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Rheumatoid Arthritis is a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body.

The disease affects more women than men and generally occurs after the ages of 40, causing diminished quality of life of many elders.

In the follow up study of 83,124 women, completed the FFQ at baseline, the diagnosis of incident RA(between 1980 and 2000) with a food frequency questionnaire (FFQ) completed every 4 years, from baseline in 1980 through 1998, researchers found that

1. Decaffeinated coffee consumption of >/=4 cups/day (compared with no decaffeinated coffee consumption) showed no subsequent risk of incident RA
2. There was no relationship of incidence of RA or reduced incidence RA in caffeinated coffee consumption, regardless to numbers of cup intake daily.
3.Total coffee and total caffeine consumption were also not associated with the risk of RA.

On the other hand, according to the Korea University College of Medicine, the numbers of coffee intake daily in reduced RA incidence were substantially different in number studies.The highest category of coffee intake in Heliovaara et al. cohort study from Finland was up to 13 cups per day, while US studies was  > 4 cups coffee intake per day.

The study also emphasized that caffeine showed no significant association of RA incidence in compared to caffeinated coffee consumption in ameliorated risk RA incidence.

Furthermore, the study in valuated coffee, tea, and caffeine consumption and risk factors for rheumatoid arthritis (RA) onset among older women, indicated that  risk of RA reduced substantially with drinking > 3 cups/day of decaffeinated coffee in compared to non drinkers.

Interestingly, women who have never drunk coffee before showed an increased risk RA if daily intake of decaffeinated coffee is over 4 cups.

Dr. Mikuls TR, the lead author said, "Decaffeinated coffee intake is independently and positively associated with RA onset" and "Further investigations of decaffeinated coffee and tea intake as arthritis risk factors are needed to verify these findings and explore their biologic basis".

Collectively, the finding evidences suggested that coffee intake is not an independent risk factor but a reduced risk parameters for onset of rheumatoid arthritis (RA) incidence, depending to numbers of cup consumption per day.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee or tea consumption and the risk of rheumatoid arthritis: a meta-analysis by Lee YH1, Bae SC, Song GG.(PubMed)
(2) Coffee, tea, and caffeine consumption and risk of rheumatoid arthritis: results from the Iowa Women's Health Study by Mikuls TR1, Cerhan JR, Criswell LA, Merlino L, Mudano AS, Burma M, Folsom AR, Saag KG.(PubMed)
(3) Coffee consumption and risk of rheumatoid arthritis by Karlson EW1, Mandl LA, Aweh GN, Grodstein F.(PubMed)

Herbal Therapy: Green tea, The Best Drink for Reduced Risk and Treatment of Hypertension

Kyle J. Norton, Master of Nutrients


Regular drinking of green tea may have a potential effect in maintaining normal blood pressure and reduced risk of hypertension , a recent study suggested.

Hypertension is abnormal high of blood pressure, one of the major risk factor in contributed early onset of cardiovascular disease.

Green tea, considered as a functional food, linking  numbers of health benefit has been reported by several renowned research and studies. However, as yin in nature herbal medicine ,or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding one slice of ginger will do the trick of neutralization.

Hypertension of male Wistar rats induced by the nitric oxide synthase inhibitor [N-nitro-L-arginine-methyl-ester (L-NAME); 20 mg/kg per day, orally, for 2 weeks], fed with green tea extract exhibited a strong effect in reduced hypertension (119 ± 1 mmHg) and higher renal sympathetic nerve activity (161 ± 12 spikes/s) than the control group (97 ± 2 spikes/s).
Green tea oral administration also showed a significant decreased in hypertensive parameter by ameliorated.arterial baroreceptor function and vascular and systemic oxidative stress.

Furthermore, in a total of 20 Otsuka Long-Evans Tokushima Fatty (OLETF) rats at 13 weeks old with matabolic syndrome randomized into a saline treated group (OLETF; n = 10) and a group treated with decaffeinated-GTE (25 mg/kg/day) (GTE-OLETF; n = 10), group fed with decaffeinated-GTE significantly reduced BP (OLETF vs. GTE-OLETF; 130 ± 7 vs. 121 ± 3 mmHg, p = 0.01) in compared control fed with saline.

The study also suggested that fed mice with green tea also showed an anti hypertensive effect in reduced vascular reactive oxygen species (ROS) formation and NADPH in generation of ROS, as well as improving endothelium (cell lines the interior surface of blood vessels and lymphatic vessels)and lymphatic vessels dependent relaxation.

Dr. Ihm SH, the lead author said," (green tea extract) improved endothelial dysfunction and IR, and eventually lowered BP".

Taking together, there is no doubt that green tea processes a significant effect in reduced risk and treatment of hypertension through reduced oxidative stress and improved vascular relaxation as well as decreased  metabolic syndrome in exaggerated hypertension.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The antioxidant effects of green tea reduces blood pressure and sympathoexcitation in an experimental model of hypertension by Garcia ML1, Pontes RB, Nishi EE, Ibuki FK, Oliveira V, Sawaya AC, Carvalho PO, Nogueira FN  Franco MD, Campos RR, Oyama LM, Bergamaschi CT.(PubMed)
(2) Decaffeinated green tea extract improves hypertension and insulin resistance in a rat model of metabolic syndrome by Ihm SH1, Jang SW, Kim OR, Chang K, Oak MH, Lee JO, Lim DY, Kim JH.(PubMed)

Food Therapy: Excessive Coffee and Coffee Caffeine Intake in Risk of Acute Diuresis?

By Kyle J. Norton


Coffee intake may have a diuretic effect in increased urinary secretion, a recent study by a renowned institute suggested

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

In an observation study of 10 healthy adults (eight males and two females; age: 27 ± 5 years, weight: 89.5 ± 14.8 kg, height: 1.75 ± 0.08 m, and body mass index: 29.1 ± 4.4 kg m-2) ingested either 200 mL of water (W), or coffee with low caffeine (3 mg kg-1, LCAF), or coffee with high caffeine (6 mg/ kg, HCAF) on three respective separate occasions, researchers found that group injected with high caffeine coffee with  (6 mg kgHCAF)demonstrated a greater diuresis during the 3-h period in compared to groups treated with W (356 ± 53 mL) and LCAF.

Furthermore, volume of urinary secretion of the injection of coffee with high caffeine groups  HCAF  was  425 mmol in compared to groups injected with W of 249 mmol) and LCAF of 177 mmol.

Dr.Seal AD1, the lead author siad, " caffeine intake of 6 mg/kg in the form of coffee can induce an acute diuretic effect, while 3 mg/kg do not disturb fluid balance in healthy casual coffee drinking adults at rest".

Contrast to the general belief, coffee consumption does not significantly reduce the fluid balance. According to the University of Birmingham, intake of coffee moderately may have similar hydrating qualities to water, when consumed in moderation.

Additionally, in the review of literature by searching the Medline database of articles published in the medical and scientific literature for the period of January 1966-March 2002, Dr. Maughan RJ, the lead author said, " acute ingestion of caffeine in large doses (at least 250-300 mg, equivalent to the amount found in 2-3 cups of coffee or 5-8 cups of tea) results in a short-term stimulation of urine output in individuals who have been deprived of caffeine for a period of days or weeks".

Interestingly, in a counterbalanced cross-over design, 50 male coffee drinkers (habitually consuming 3-6 cups per day) participated in two trials, each lasting three consecutive days, with controlled physical activity, food and fluid intake, participants also consumed either 4×200 mL of coffee containing 4 mg/kg caffeine (C) or water (W), researchers filed the following results
1. Intake of coffee during this period showed no significant changes in total body water (TBW) with no differences between trials.
2. Volume urinary secretion showed no difference in the period of examination and between 2 groups.
3. No change of nude body mass measurement (BM) in the period and between 2 groups.

Dr. Seal AD, the lead author said, " (there were) no significant differences across a wide range of haematological and urinary markers of hydration status between trials".

The implication of this result insisted that consumption of caffeine-containing beverages as part of a normal lifestyle do not lead to fluid loss in excess of the volume or poor hydration status other than people with deprived of caffeine for a period of days or weeks.

Taking tighter, the contradictory results regarded to coffee and coffee caffeine intake  in increased urinary volume secretion may require more illustrations from a large sample sizes and mutli centers studies before the claim can be made either ways.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee with High but Not Low Caffeine Content Augments Fluid and Electrolyte Excretion at Rest by Seal AD1, Bardis CN2, Gavrieli A2, Grigorakis P2, Adams JD1, Arnaoutis G2, Yannakoulia M2, Kavouras SA1,3(PubMed)
(2) No evidence of dehydration with moderate daily coffee intake: a counterbalanced cross-over study in a free-living population by Killer SC1, Blannin AK1, Jeukendrup AE1.(PubMed)

Food Therapy: Maternal Coffee Intake > 4 Cups/Day in Risk of Miscarriage?

By Kyle J. Norton


Risk of miscarry is increased substantially in excessive coffee drinkers during pregnancy, an Asian study suggested

Coffee, one of most popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Miscarriage is the expulsion of a fetus from the womb between the 12th and 28th weeks of gestation.

In a case-controlled study conducted in Milan of 561 (72%) cases of spontaneous abortion and 877 (57%) controls,coffee drinking during the first trimester of the index pregnancy with healthy women who gave birth at term (> 37 weeks gestation) to healthy infants as control,  researchers reported that  the risk of miscarry is classified as follow
1. Coffee intake of 1, 2 or 3, and 4 or more cups of coffee per day, are associated to increased risk of 1.2, 1.8 and 4.0, respectively in compared to non drinkers.
2. The risk of pregnancy loss also is associated to the duration in years of coffee drinking. The estimated multivariate odds ratios of spontaneous abortion were 1.1 in comparison to non-coffee intake group.

Further more, in the evaluated effect of caffeine in influence of miscarriage researchers at the Boston University School of Public Health, conducted a prospective cohort study included 5132 Danish women planning pregnancy, enrolled from 2007 to 2010, after carefully assessed the returned beverage consumption on questionnaires, researcher found that a significantly miscarried risk is 1.62 higher in women consumed more that 300 mg/day of caffeine per day, in compared to 1.09 in women who consumes <100 mg/day. Specifically, women with daily intake of caffeine of
1. <100 mg/day showed a materially associated with SAB risk of 1.09
2. 100-199mg/day showed a materially associated with SAB risk of 0,89
3. 200-299mg/day showed a materially associated with SAB risk of 1.33

Other, in prospective cohort study included 15,590 pregnancies from 11,072 women with no history of SAB in the Nurses' Health Study II (1991-2009) with beverage intake assessed every 4 years using a validated questionnaire in case pregnancies lost spontaneously at <20 weeks gestation, total coffee intake had a positive, linear association with SAB.

In compared to non pre-pregnancy coffee intake, risk of SAB increased by 20% for women consuming ≥4 servings/day.

More importantly, Dr. Gaskins AJ, the lead author said, "Pre-pregnancy coffee consumption at levels ≥4 servings/day is associated with increased risk of SAB, particularly at weeks 8-19".

Taking together, there is no doubt that coffee may contribute to a relative risk of miscarry for women consuming more than 4 cup per day. Women who are pregnant between 12 to 28 weeks of gestation with excessive coffee intake habit are recommended to consult with their doctors.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee consumption and risk of hospitalized miscarriage before 12 weeks of gestation by Parazzini F1, Chatenoud L, Di Cintio E, Mezzopane R, Surace M, Zanconato G, Fedele L, Benzi G.(PubMed)
(2) Caffeine and caffeinated beverage consumption and risk of spontaneous abortion by Hahn KA1, Wise LA2, Rothman KJ3, Mikkelsen EM4, Brogly SB5, Sørensen HT6, Riis AH4, Hatch EE5.(PubMed)
(3) Pre-pregnancy caffeine and caffeinated beverage intake and risk of spontaneous abortion by Gaskins AJ1,2, Rich-Edwards JW3,4,5, Williams PL3,6, Toth TL7, Missmer SA3,4,8,9, Chavarro JE10,3,4.(PubMed)

Alternative Therapy: Yoga in Improved Physical and Psychological Aspects in Alzheimer's disease and AD Caregivers

By Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)

Yoga used in combination with compassion meditation may have a positive impact in improved quality of life, attention, vitality,... in patients with Alzheimer's disease, a recent study suggested.

Yoga, the ancient technique practice for harmonized external and internal body well being, through breath control, meditation, bodily movement and gesture..... has been well known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In a total of 46 volunteers randomly allocated to two groups, the yoga and compassion meditation program group (n = 25), with program lasted 8 weeks, comprised three yoga and meditation practices per week, with each session lasting 1 h and 15 min and the control group (CG), researchers, after assessed other co founders, found that yoga attendees expressed statistically significant improvements (P < 0.05) on quality of life, attention, vitality and self-compassion scores  in compared to control.

Additionally, in the examined feasibility of older adults with Alzheimer's disease (AD)-type dementia in 8 weeks of the Sit 'N' Fit Chair Yoga Program, researchers indicated that all participants showed a steady and progressive improvement over the course of program in 4 weeks, 8 weeks, and 1 month period.

Due to small size of this sample, Dr, McCaffrey R, the led researchers said, "Further study, using a larger sample and including a control group, is needed to fully determine the effect of the Sit 'N' Fit Chair Yoga Program on older adults with moderate to severe AD".

More importantly, in the concern of familial caregivers of patients of Alzheimer's disease in reduced quality of life and increased stress levels, researchers conducted a study of 46 volunteers randomly assigned to participate in a stress-reduction program for a 2-month period (yoga and compassion meditation program-YCMP group) (n = 25), at the end, familial caregivers attended the program group exhibited a reduction of the stress, anxiety, and depression levels, as well as a reduction in the concentration of salivary cortisol.

Taking altogether, Yoga, the integrated form of exercise not only improved physical and psychological aspects in patients with moderate and severe AD, but also reduced stress, anxiety and depression of familial caregiver in AD patients.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Yoga and compassion meditation program improve quality of life and self-compassion in family caregivers of Alzheimer's disease patients: A randomized controlled trial by Danucalov MA1,2, Kozasa EH1,3, Afonso RF3, Galduroz JC1, Leite JR1.(PubMed)
(2) The effect of chair yoga in older adults with moderate and severe Alzheimer's disease by McCaffrey R, Park J, Newman D, Hagen D.(PubMed)
(3) A yoga and compassion meditation program reduces stress in familial caregivers of Alzheimer's disease patients by Danucalov MA1, Kozasa EH, Ribas KT, Galduróz JC, Garcia MC, Verreschi IT, Oliveira KC, Romani de Oliveira L, Leite JR.(PubMed)

Food Therapy: Coffee, A Potent and Functional Food in Reduced Risk of Endometrial Cancer

By Kyle J. Norton


In take of caffeinated coffee may have a reduced risk and treatment of Endometrial cancer, an Asian joint study supposed.

Coffee, becoming a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Endometrial cancer is a medical condition characterized by cell growth disorderly and uncontrollably in the endometriosis. In the later stage, the cancer can spread to distant parts of tissues or organs.

In the review of published data of a total 1,534,039 participants from 13 published articles added in this meta-analysis, researchers found that reduced risk of endometrial cancers incidence is associated to coffee intake to patients never treated with any forms hormone therapies and either overweight or obese.

The relative odd ratio in these group of people were 0.66 and 0.77, respectively,  correlated to decaffeinate and caffeine coffee intake.

In fact, the risk of endometrial cancer deceased by 5% for every additional cup of coffee consumed.

In compared to decaffeinate coffee, caffeinated coffee showed a stronger in attenuated risk of 7% instead of 4% in decaffeinated intake,

The study also addressed that caffeine found in coffee may have a potential in enhanced coffee effects in ameliorated endometrial cancer expression. Risk of cancer is reduced by 4% for every 100mg caffeine intake per day.

In a 26 years follow-up study of 67,470 female participants aged 34 to 59 in 1980 of the Nurses' Health Study (NHS), returned questionnaires by the participants indicated that
1. Women drinking less than 4 cups of coffee per day were not associated with endometrial cancer risk.
2. Women drinking more than 4 cups coffee per day displayed a 25% decreased risk of endometrial cancer in compared to women who drank fewer that 1 cup per day.

Dr. Je Y, the lead author said, "For decaffeinated coffee consumption, a suggestive inverse association was found among women who consumed 2 or more cups per day versus <1 cup/mo."

Interestingly, the menopause women, the primary analyses included 45,696 women and 427 incident endometrial cancer cases, diagnosed over a total of 342,927 person-years of follow-up, suggested that
1. No association of endometrial cancer risk in coffee consumption in compared to non-daily drinkers (none or <1 cup/day),
2. Women who drank ≥4 cups/day have a relative odd ration of were 0.86. 0.63, for total coffee with 0.89 for caffeinated coffee, and 0.51 (95% CI 0.25, 1.03) for decaf coffee.
3. In obese women,  compared to control group (none or <1 cup/day), women who drank ≥2 cups/day had a relative odd ratio of 0.72 for total coffee, 0.66 for caffeinated coffee. and 0.67 decaffeinated coffee drinkers.

Taking together, intake of coffee is associated to reduced risk of endometrial cancer in healthy and menopause women regardless to weight mass.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee consumption and risk of endometrial cancer: a dose-response meta-analysis of prospective cohort studies by Zhou Q1, Luo ML2, Li H3, Li M4, Zhou JG5.(PubMed)
(2) A prospective cohort study of coffee consumption and risk of endometrial cancer over a 26-year follow-up by Je Y1, Hankinson SE, Tworoger SS, De Vivo I, Giovannucci E.(PubMed)

Food Therapy: Maternal Coffee > 4 Cups/day or Coffee Caffeine > 2 Cups/day Intake in Increased Risk of Congenital Malformations

By Kyle J. Norton


A renowned institute suggested that coffee consumption in high doses during pregnancy may have a directed influence in congenital malformations of fetus.

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Congenital malformation is birth defect with structural or functional abnormalities existed in the mother womb, before the infant was born.

In 755 pairs of mothers of malformed children and their controls personally interviewed soon after delivery consisted of mothers of children with 112 defects of the central nervous system, 241 orofacial clefts, 210 structural defects of the skeleton, and 143 cardiovascular malformations, researchers suggested that although coffee consumption during pregnancy was similar for the mothers of malformed or non-malformed children, high coffee drinking at least four cups of coffee a day displayed a significantly increased relative risk of 1.3, in compared to with those not consuming coffee of 0.7.

Other, in the case-control study assessed associations between maternal dietary caffeine and congenital LDs using data from the National Birth Defects Prevention Study (NBDPS), with 844 LD cases and 8069 controls from 1997 to 2007, researchers, after adjusting to other risk factors found that total caffeine intake daily has a moderated effect in increased risk of congenital limb deficiencies (LDs) in compared to the lowest intake, regardless to amount of caffeine intake.

Further more, in multi-center case-control study interviewed mothers of 776 SB cases and 8,756 controls about pregnancy events and exposures between 1988-2012, according to the returned questionnaire, caffeine intake during the first lunar month of pregnancy  > 2 cups per day may have a directed effect in increased risk of Spina bifida.

Spina bifida is a congenital defect of the spine induced paralysis of the lower limbs, and sometimes mental handicap.

Additionally, according to data extracted from the National Birth Defects Prevention Study, a population-based case-control study in examine the associations between maternal self-reports of exposures and occurrence of choanal atresia in their offspring in 117 case and 8350 control mothers with deliveries from 1997 through 2007, researchers expressed that pre-pregnancy daily coffee intake of 3 or more cups displays a traumatic risk of offspring choanal atresia in compared to those who consumed less than 1 cup per day.

Choanal atresia is a congenital defect of the back of the nasal passage (choana) is blocked due to abnormal bony or soft tissue.

Taking altogether, intake of coffee more than 4 cups/day or Coffee Caffeine > 2 Cups/day during pregnancy may be considered as risk factors in increased risk of congenital malformations. Women with previous birth of congenital malformations, should reduce intake of coffee consumption to < or = 2 cups per day.

 

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee consumption during pregnancy and selected congenital malformations: a nationwide case-control study by Kurppa K, Holmberg PC, Kuosma E, Saxén L.(PubMed)
(2) Maternal caffeine consumption and risk of congenital limb deficiencies by Chen L1, Bell EM, Browne ML, Druschel CM, Romitti PA, Schmidt RJ, Burns TL, Moslehi R, Olney RS; National Birth Defects Prevention Study.(PubMed)
(3) Risk of spina bifida and maternal cigarette, alcohol, and coffee use during the first month of pregnancy by Benedum CM1, Yazdy MM, Mitchell AA, Werler MM.(PubMed)