Food Therapy: Coffee Intake > 2 cups/day In Increased Risk Type ! Diabetes

By Kyle J. Norton

Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite responses.
Coffee, has become a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Intake of coffee in adulthood may increase risk of autoimmune diabetes or type 1 diabetes, a study of Institute of Environmental Medicine, Karolinska Institutet suggested.

In a population-based case-control study with incident cases of adult onset (≥ 35 years) diabetes, including 245 cases of latent autoimmune diabetes in adults (glutamic acid decarboxylase antibody positive), 759 cases of Type 2 diabetes (glutamic acid decarboxylase antibody negative), together with 990 control subjects without diabetes, randomly selected from the population, after inspection of the returned questionnaire, researchers found that coffee intake may be associated with an increased risk of high glutamic acid decarboxylase antibody latent autoimmune diabetes in adults.

The relative odd ratio of these population was 1.11 in compared to non drinkers.
The risk of disease development increased by 15.2% (P = 0.0268) for every additional cup intake.

Dr. Löfvenborg JE, the lead author said, " coffee may be associated with development of autoimmunity and possibly an increased risk of more Type 1-like latent autoimmune diabetes in adults".

More importantly, in the review of the association between coffee intake, its influence on the immune system and the insurgence of the most relevant autoimmune diseases conducted by the joint study lead by the Tel-Aviv University coffee intake showed a selectively both in increased(rheumatoid arthritis (RA) and type 1 diabetes mellitus (T1DM)) and decreased(multiple sclerosis, primary sclerosing cholangitis, and ulcerative colitis) risk of some auto immune diseases.

Particularly in type 1 diabetes, Dr. Sharif K, the lead author said, "Coffee intake led to a decrease in insulin sensitivity in T1DM" and " coffee consumption was shown to influence disease course and management options".

Remarkably, in the study of some diabetic children younger than 15 years, and diagnosed from September 1986 to the end of April 1989, with 600 newly diagnosed diabetic children and 536 randomly selected population-based children, researchers postulated that risk for type 1 diabetes were increased in the children who consumed at least 2 cups of coffee daily in compared to other groups.even after adjusting to other odd factors.

The finding evidences suggested that coffee intake daily and regular may have significant impact in increased development of type 1 diabetes in children and adults population regardless amount of cups intake. therefore, people with family history of type 1 diabetes should reduced intake of less than 2 cups of coffee per day.

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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee consumption and the risk of latent autoimmune diabetes in adults--results from a Swedish case-control study by Löfvenborg JE1, Andersson T, Carlsson PO, Dorkhan M, Groop L, Martinell M, Rasouli B, Storm P, Tuomi T, Carlsson S.(PubMed)
(2) Coffee and autoimmunity: More than a mere hot beverage! by Sharif K1, Watad A1, Bragazzi NL2, Adawi M3, Amital H1, Shoenfeld Y4.(PubMed)
(3) Is children's or parents' coffee or tea consumption associated with the risk for type 1 diabetes mellitus in children? Childhood Diabetes in Finland Study Group by Virtanen SM1, Räsänen L, Aro A, Ylönen K, Lounamaa R, Akerblom HK, Tuomilehto J.(PubMed)

Food Therapy: Coffee Increases Risk of GERD in Geographical or Racial Differences?

By Kyle J. Norton


Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite responses.

Epidemiological studies linking coffee intake in risk of Gastro-esophageal reflux disease have been inconsistent and contradictory.

Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Gastro-esophageal reflux disease is a digestive disorder, affected ring of muscle between the esophagus and stomach, inducing symptoms of heartburn or acid indigestion.

Pathophysiological changes in esophageal functions that occur with aging may, at least in part is responsible for the high prevalence of Gastro-esophageal reflux disease (GERD).

In the review of online literature published database from Med, EMBASE, and Cochrane Library up to December 2012, researchers at the Seoul National University Hospital filed the following results
1. A meta-analysis showed that intake of coffee exerted no significantly associated risk of GERD.
2. Only the endoscopy group showed a significantly higher odds ratio risk induced by coffee in compared to other subgroups.

But after accounting to other risk factors, such as amount of coffee intake, quality of study, and assessment of exposure researchers found that coffee intake do not associate to increased risk of GERD.

Other, in the study to investigate the association of habits and social conditions reported lead to reflux in the employees of hospital, researchers indicated that even with the the prevalence rate of 21.7% of GERD incidence in this group of participants, intake of coffee daily and regularly showed no effect in increased risk GERD, regardless to amount of coffee intake per day.

Contrast to the above studies,  the Korean prospective study of recruited subjects with GERD visited a health promotion center for upper gastrointestinal cancer surveillance at Hallym Medical Center (five institutions) between January 2008 and February 2009, researchers reported that
1. Coffee intake showed a significant correlation to independent risk of GERD in young and adults groups
2. and Coffee intake was considered as a major risk factor in elderly group.

Dr. Park CH, the lead author said, "The risk factors for RE according to age group were found to differ. In elderly group, Helicobacter pylori infection was not a significant protective factor contrary to young and adult groups.

Taking altogether, Coffee intake showed a conflict result in risk of GERD, probably due to geographic difference as Asian population are susceptible to risk of the diseases in compared to population in the West. Further studies are necessary.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Association between coffee intake and gastroesophageal reflux disease: a meta-analysis by Kim J1, Oh SW, Myung SK, Kwon H, Lee C, Yun JM, Lee HK; Korean Meta-analysis (KORMA) Study Group.(PubMed)
(2) The prevalence of gastroesophageal reflux disease among hospital employees by Ercelep OB1, Caglar E, Dobrucali A.(PubMed)
(3) Differences in the risk factors of reflux esophagitis according to age in Korea by Park CH1, Kim KO, Baek IH, Choi MH, Jang HJ, Kae SH, Kim JB, Baik GH, Shin WG, Kim KH, Kim HY.(PubMed)

Herbal Therapy: Andrographis Paniculata, the Best Anti Skin Aging Natural herbal Medicine

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite outcomes.

Andrographis paniculata, the forgotten herbal medicine may have a potential effect in delay skin aging, however, its therapeutic properties have rarely been applied in the field of skin care.

Skin aging, a naturally biological process caused by thinning of layer  just underneath the skin can not be prevented but delayed


Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...

According of the joint study lead by the Biospectrum Life Science Institute, in vitro, ex vivo, and in vivo, Andrographis paniculata extract (APE) exhibited a significant anti aging activity through ameliorate the process of loss of human epidermal stem cells (EpSCs).

Truly, the epidermal stem cells (EpSCs). treated with Andrographis paniculata extract (APE) exerted an anti aging effect by increased cells quantity significantly in the G2/M and S stages in cell division in a dose-dependent manner. 

The study also found that APE-treated EpSCs enhanced the Type 1 collagen production in normal human fibroblasts (NHFs).and improved skin hydration, dermal density, wrinkling, and sagging significantly.

In UV-Induced Skin Photoaging Andrographolide sodium bisulfate (ASB), a water-soluble form made from andrographolide increased the function of antioxidants in attenuated oxidative stress and inflammation responsible for ultraviolet (UV) irradiation causing skin damage and premature aging.
Dr. the lead anthor in the study of ultraviolet (UV) induced skin aging said, "topical administration of ASB suppressed the UV-induced skin thickness, elasticity, wrinkles, and water content, while ASB, especially at dose of 3.6 mg/mouse, increased the skin collagen content by about 53.17%, decreased the epidermal thickness by about 41.38%, and prevented the UV-induced disruption of collagen fibers and elastic fibers"

Furthermore, the study also proposed, the anti aging effect of the herbal Andrographis may be attributed  to anti enzymes in inhibited free radicals induced of oxidative stress and reduced the expression of pro inflammatory cytokins.

Taking together, Andrographis paniculata expressed significantly anti-skin aging effects through various mechanisms, but intake of large amount should be taken with care.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) The Antiaging Properties of Andrographis paniculata by Activation Epidermal Cell Stemness by You J1, Roh KB2, Li Z3, Liu G4, Tang J5, Shin S6, Park D7, Jung E8.(PubMed)
(2) Andrographolide Sodium Bisulfate Prevents UV-Induced Skin Photoaging through Inhibiting Oxidative Stress and Inflammation by Janis Ya-Xian Zhan,1 Xiu-Fen Wang,1 Yu-Hong Liu,1 Zhen-Biao Zhang,1 Lan Wang,2 Jian-Nan Chen,1 Song Huang,1 Hui-Fang Zeng,2 and Xiao-Ping Lai1(Hindawi)

Food Therapy: Coffee and Coffee caffeine, Risk of Endometriosis?

By Kyle J. Norton

Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite responses.In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Coffee is a popular and social beverage all over the world, particularly in the West, made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Epidemiological studies do not agreed that coffee regular intake is associated to risk of endometriosis, according to the IRCSS Fondazione Ca' Granda.

In a meta-analysis of epidemiological studies published up to January 2013 to analyze the relative risks (RR) of endometriosis for any, high and low versus no coffee/caffeine consumption, researchers filed the following reports

1. A total of six case-control and two cohort studies, including a total of 1,407 women with endometriosis were found in this review
2. The relative ratio were 1.26 and 1.13 for coffee and caffeine consumed participants respectively, in compared to non-consumption group
3. The overall relative ratio was 1.18 in coffee consumption group after taking into account of numbers of cup of coffee intake and other risk factors
4. Risk of endometrosis increased reduced to 1.09 in compared to high and low caffeine consumption as compared to no consumption, respectively.

Dr. Chiaffarino F, based on the information of this review said, "The present meta-analysis provided no evidence for an association between coffee/caffeine consumption and the risk of endometriosis. Coffee/caffeine consumption, as currently used in diet, does not carry a health risk".

Other, in the examine data from two case-control studies conducted in Northern Italy between 1984 and 1999 with 504 women aged < 65 years (median age 33 years, range 20-65) with a laparoscopically confirmed diagnosis of endometriosis, admitted to a network of obstetrics and gynaecology departments in Milan, Brescia and Pavia and 504 healthy women acted as control, researchers at the Università di Milano after adjusting to other risk factors suggested that there may be a link between diet and risk of endometriosis but coffee intake do not form significant risk of endometriosis incidence.

Contrast to the above studies, according to the cross-sectional study included 28,822 women, 1,228 women with endometriosis and the self-reported diagnosis was confirmed by medical records conducted by the joint institutes lead by the Department of Medical Epidemiology and Biostatistics, Karolinska Institute, coffee intake was associated to risk of development of endometriosis.

The study also indicated that even coffee showed a positive association to risk of endometriosis, but future studies are needed to explore the significance of other factors such as age at menarche, level of education, body mass index (BMI), parity, oral contraceptive (OC) use, infertility, smoking, and alcohol intake in the diagnosis of endometriosis and understanding of its etiology.

Taking altogether, although there are conflict information related to coffee intake and risk of endometriosis, but women with family history of ednometriosis are recommended to reduce intake of coffee and coffee caffeine and consult with their doctors before applying high amount of coffee daily.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee and caffeine intake and risk of endometriosis: a meta-analysis by Chiaffarino F1, Bravi F, Cipriani S, Parazzini F, Ricci E, Viganò P, La Vecchia C.(PubMed)
(2) Selected food intake and risk of endometriosis by Parazzini F1, Chiaffarino F, Surace M, Chatenoud L, Cipriani S, Chiantera V, Benzi G, Fedele L.(PubMed)
(3) Reproductive and Lifestyle Factors Associated with Endometriosis in a Large Cross-Sectional Population Sample by Saha R1, Kuja-Halkola R2, Tornvall P1, Marions L1.(PubMed)

Herbal Therapy: Andrographis, The Immunomodulatory Whole Herb Medicine

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

In Herbal Medicine, symptoms of the disease can only be eased gradually, depending to stages of the treatment which directly address to the cause of the disease.

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,....

Immunomodulatory Activity is the action in regulated immune response or the functioning of the immune system against forming of diseases, including stimulating production of antibody and
inhibited white blood cells in induced inflammation,.....

Andrographis processed significant effects in enhanced immune function, through modulation of immune responses, a renowned institute study suggested.

According to the Prin. K. M. Kundnani College of Pharmacy, HN-02, an extract containing a mixture of andrographolides plus 14-deoxyandrographolide and 14-deoxy-11,12-didehydroandrographolide together [12 +/- 3 %]) in a pure powder form at 1.0, 1.5, and 2.5 mg/kg on different in vivo and in vitro experimental models, demonstrated  the ability in enhanced immune function by modulation of immune responses altered during antigen interaction, and to reverse the immunosuppression induced by cyclophosphamide (CYP).

Dr. Naik SR, the lead author said, " HN-02 treatment significant increase in total WBC count" and "elevated the depressed hemagglutination antibody (HA) titer and increased the number of plaque-forming cells (PFCs) in the spleen cells of mice".

Other researchers in the evaluation of the immunomodulatory activity of herbal andrographis indicated that andrographis paniculata exhibited the effect through genes expression involved in immune cell activation and migration and various inflammatory responses, including wound healing, angiogenesis, and blood pressure modulation.

The study also identified chemical compound of lipopolysaccharide in Andrographis paniculata as one of natural and most active immunostimulatory component.

Additionally, dichloromethane fraction of the methanolic extract.of Andrographis paniculata also expressed an impressive inhibition against testing human cancer and immune cells.
At low concentration, the dichloromethane extract enhanced immune function in attenuated the proliferation of HT-29 (colon cancer) cells and human peripheral blood lymphocytes (HPBLs).

Furthermore, the study also found, andrographolide, another major compound in Andrographis paniculata exhibited immune ability to suppress irregular cell growth and cancer activity on diverse cancer cells in different types of human cancers.

Taking altogether, there is no doubt, that Andrographis consisted a strong immunomodulatory activity in regulated immune respond against procession of irregular cell growth and over reaction of foreign harmful substances, but intake of large amount should be taken with care.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Evaluation of immunomodulatory activity of an extract of andrographolides from Andographis paniculata by Naik SR1, Hule A.(PubMed)
(2) Regulation of inflammatory gene expression in PBMCs by immunostimulatory botanicals by Denzler KL1, Waters R, Jacobs BL, Rochon Y, Langland JO.(PubMed)
(3) Anticancer and immunostimulatory compounds from Andrographis paniculata by Kumar RA1, Sridevi K, Kumar NV, Nanduri S, Rajagopal S.(PubMed)

Food Therapy: Coffee and Coffee Caffeine In Reduced Risk and Symptoms of Non Alcoholic Liver Disease

By Kyle J. Norton

In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Coffee, second to green tea, is a popular and social beverage all over the world, particular in the West, made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Coffee and coffee caffeine may have a profound effect in reduced symptoms of non alcoholic liver disease, renowned institute studies suggested.

Non-alcoholic fatty liver disease (NAFLD) is one of the types of fatty liver caused by fat accumulated (steatosis) in the liver other than excessive alcohol drinking.

According to a retrospective cross-sectional study on patients with non-alcoholic fatty liver disease (NAFLD), hepatitis C virus (HCV), and hepatitis B virus (HBV) infection to determine the effects of coffee intake on a non-invasive marker of liver fibrosis, coffee intake of 2 or more cups per day demonstrated a significant reduced liver symptom of stiffness, after adjustment for age, gender, smoking, alcohol consumption, in compared to other subgroups.

Additionally, in the review of epidemiological and clinical evidence by the Zhejiang University, coffee intake may have a profoundly reduced severity and risk of non-alcoholic fatty liver disease (NAFLD) prevalence.

In fact,  the effect of coffee in attenuated risk of non-alcoholic fatty liver disease (NAFLD) incidence may be also involved other chemical constituents other than caffeine.

Dr. Chen S, the lead researchers suggested that said, "Several possible mechanisms underlying coffee's hepatoprotective effects in NAFLD include antioxidative, anti-inflammatory, and antifibrotic effects".

Interestingly, the review of literature published in database of Medline and Embase up to March 2015, showed that coffee and coffee caffeine intake have a strong impact in protect liver against complications of fibrosis incidence.

Information collected indicated that coffee and coffee caffeine intake have a enormous demonstration in ameliorated risk and symptoms of Non alcoholic liver disease, but some researchers suggested that other components such as  antioxidative, anti-inflammatory, and antifibrotic effects may also play an important role in enhancement of these results.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee Intake Is Associated with a Lower Liver Stiffness in Patients with Non-Alcoholic Fatty Liver Disease, Hepatitis C, and Hepatitis B by Hodge A1,2, Lim S3, Goh E4, Wong O5, Marsh P6, Knight V7, Sievert W8,9, de Courten B10.(PubMed)
(2) Coffee and non-alcoholic fatty liver disease: brewing evidence for hepatoprotection? by Chen S1, Teoh NC, Chitturi S, Farrell GC.(PubMed)
(3) Coffee and tea consumption in relation with non-alcoholic fatty liver and metabolic syndrome: A systematic review and meta-analysis of observational studies by Marventano S1, Salomone F2, Godos J3, Pluchinotta F4, Del Rio D5, Mistretta A1, Grosso G6.(PubMed)

Herbal Therapy: Andrographis, The Best Whole Herb Medicine for Treatment of Ulcerative Colitis

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite outcomes.
Andrographis paniculata expressed a significant efficacy similar to those of mesalamine, for treatment of  ulcerative colitis, a study by renowned institute suggested.

Ulcerative colitis is condition of inflammatory bowel disease (IBD) inducing long-lasting inflammation and ulcers in the digestive tract.

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,....

In a randomized, double-blind, placebo-controlled trial in evaluated the efficacy of A. paniculata extract (HMPL-004) in 224 adults with mild-to-moderate ulcerative colitis. with patients randomized to A. paniculata extract (HMPL-004) 1,200 mg or 1,800 mg daily or placebo for 8 weeks, patients treated with A. paniculata extract (HMPL-004) at a dose of 1,800 mg daily achieve clinical response than those receiving placebo.

The study also discovered that 60 and 53% of patients treated with A. paniculata groups experienced adverse effect at doses of 1,200 mg and 1,800 mg daily respectively in comparison to 60% in the placebo group.

Dr. Sandborn WJ, the lead author in the study said, "Andrographis paniculata has in vitro inhibitory activity against TNF-α, IL-1β and NF-κB. A pilot study of A. paniculata extract (HMPL-004) suggested similar efficacy to mesalamine for ulcerative colitis."

Other study involved herbal extract HMPL-004 also support the use of herbal extract for treatment in patients with mild-to-moderate ulcerative colitis, according to the randomised, double-blind, multicentre, 8-week parallel group study conducted using HMPL-004 with 1200 mg/day in compared with 4500 mg/day of slow release mesalazine (mesalamine) granules in same group.

In fact, in comparison to mesalazine, HMPL-004 exhibited a 21% and 76% of more efficacy in treated patients, compared to 16% and 82% of mesalazine-treated patients through the colonoscopy, remission and response.

Although HMPL-004 may be an efficacious alternative to mesalazine in treating ulcerative colitis, the herbal medicine can only prescribed by herbalist to prevent overdose toxicity.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Andrographis paniculata extract (HMPL-004) for active ulcerative colitis by Sandborn WJ1, Targan SR, Byers VS, Rutty DA, Mu H, Zhang X, Tang T.(PubMed)
(2) Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis - a double-blind comparison with sustained release mesalazine by Tang T1, Targan SR, Li ZS, Xu C, Byers VS, Sandborn WJ.(PubMed)